Aliases & Classifications for Enophthalmos

MalaCards integrated aliases for Enophthalmos:

Name: Enophthalmos 12 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11175
ICD10 32 H05.4 H05.40
ICD9CM 34 376.5 376.50
MeSH 41 D015841
NCIt 46 C79552
UMLS 69 C0014306

Summaries for Enophthalmos

MalaCards based summary : Enophthalmos is related to silent sinus syndrome and horner's syndrome. An important gene associated with Enophthalmos is TFAP2A (Transcription Factor AP-2 Alpha). The drugs Bone Density Conservation Agents and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 72 Enophthalmos is the posterior displacement of the eyeball within the orbit due to changes in the volume... more...

Related Diseases for Enophthalmos

Diseases related to Enophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 silent sinus syndrome 11.3
2 horner's syndrome 11.3
3 neurofibromatosis, type iv, of riccardi 10.1
4 sinusitis 10.0
5 maxillary sinusitis 9.9
6 lupus erythematosus 9.9
7 fibrosis of extraocular muscles, congenital, 1 9.8
8 aging 9.8
9 microphthalmia, isolated 2 9.8
10 glass syndrome 9.8
11 hydrocephalus 9.8
12 chronic maxillary sinusitis 9.8
13 choroiditis 9.8
14 linear scleroderma 9.8
15 blood group, i system 9.7
16 blue rubber bleb nevus 9.7
17 duane retraction syndrome 1 9.7
18 hemifacial atrophy, progressive 9.7
19 systemic lupus erythematosus 9.7
20 neurofibromatosis, type i 9.7
21 retinoblastoma 9.7
22 strabismus 9.7
23 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.7
24 hallermann-streiff syndrome 9.7
25 meningioma, familial 9.7
26 mycobacterium tuberculosis 1 9.7
27 episodic pain syndrome, familial, 1 9.7
28 systemic scleroderma 9.7
29 lymphoma 9.7
30 ptosis 9.7
31 entropion 9.7
32 lagophthalmos 9.7
33 ectropion 9.7
34 facial hemiatrophy 9.7
35 intracranial hypotension 9.7
36 exophthalmos 9.7
37 neurofibroma 9.7
38 esotropia 9.7
39 orbit lymphoma 9.7
40 orbital lymphoma 9.7
41 orbital varix 9.7
42 exotropia 9.6 CHN1 TNNI3K
43 congenital ptosis 9.5 CHN1 TNNI3K
44 tukel syndrome 9.4 CHN1 TNNI3K
45 ocular motility disease 9.3 CHN1 TNNI3K
46 orbital disease 8.2 CHN1 EPB41L1 FAF2 SASS6 TFAP2A TNNI3K

Graphical network of the top 20 diseases related to Enophthalmos:



Diseases related to Enophthalmos

Symptoms & Phenotypes for Enophthalmos

GenomeRNAi Phenotypes related to Enophthalmos according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.17 EPB41L1 TFAP2A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.17 TFAP2A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.17 TFAP2A
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.17 EPB41L1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.17 EPB41L1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.17 EPB41L1

Drugs & Therapeutics for Enophthalmos

Drugs for Enophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Bone Density Conservation Agents Phase 2
2 Calcium, Dietary Phase 2
3
Cocaine Approved, Illicit 50-36-2 446220 5760
4 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Polycaprolactone / Tricalcium Phosphate (PCL/TCP) v Titanium Orbital Implant : Randomised Trial Unknown status NCT01119144 Phase 2
2 Reconstruction of the Orbit With a Bioresorbable Polycaprolactone Implant Completed NCT00233922 Phase 2
3 Use of a Low Profile Titanium Mesh in Orbital Reconstruction Completed NCT01432964

Search NIH Clinical Center for Enophthalmos

Cochrane evidence based reviews: enophthalmos

Genetic Tests for Enophthalmos

Anatomical Context for Enophthalmos

MalaCards organs/tissues related to Enophthalmos:

38
Eye, Bone, Brain

Publications for Enophthalmos

Articles related to Enophthalmos:

(show top 50) (show all 267)
# Title Authors Year
1
Autologous Fat Graft for the Treatment of Sighted Posttraumatic Enophthalmos and Sunken Upper Eyelid. ( 29369151 )
2018
2
Differences in interpalpebral fissure measurement in patients with unilateral enophthalmos resulting from orbital wall fractures. ( 28344027 )
2017
3
Development of late enophthalmos in pure blowout fractures: methodologic issues in prediction studies. ( 28983893 )
2017
4
Secondary Repair of Posttraumatic Enophthalmos and Extraocular Movement Disorders. ( 29195241 )
2017
5
Comments on "A Straightforward Method of Predicting Enophthalmos in Blowout Fractures Using Enophthalmos Estimate Line". ( 28279685 )
2017
6
Isolated nonpulsatile enophthalmos in neurofibromatosis: An uncommon entity. ( 29044092 )
2017
7
Prediction of Late Enophthalmos Using Preoperative Orbital Volume and Fracture Area Measurements in Blowout Fracture. ( 28834836 )
2017
8
Secondary Reconstruction of Posttraumatic Enophthalmos with Titanium Mesh and Buccal Fat Pad Graft: Case Report. ( 28825031 )
2017
9
Orbital Volume Augmentation with Calcium Hydroxyapatite Filler in Anophthalmic Enophthalmos. ( 29090049 )
2017
10
Secondary Reconstruction of Residual Enophthalmos Using an Endoscope and Considering the Orbital Floor and Medial Wall Slope. ( 27244206 )
2016
11
Sliced Costochondral Chip Grafts in Posttraumatic Enophthalmos Correction. ( 28027179 )
2016
12
A Straightforward Method of Predicting Enophthalmos in Blowout Fractures Using Enophthalmos Estimate Line. ( 27542546 )
2016
13
Antral bony wall erosion, trigeminal nerve injury, and enophthalmos after root canal surgery. ( 27465790 )
2016
14
Linear scleroderma en coup de sabre presenting with positional diplopia and enophthalmos. ( 27754909 )
2016
15
Can customized implants correct enophthalmos and delayed diplopia in post-traumatic orbital deformities? A volumetric analysis. ( 27157630 )
2016
16
Prediction of the development of late enophthalmos in pure blowout fractures: delayed orbital tissue atrophy plays a major role. ( 27198642 )
2016
17
Predicting late enophthalmos: Differences between medial and inferior orbital wall fractures. ( 27769606 )
2016
18
The imploding antrum: An unusual case of nontraumatic painless enophthalmos. ( 27905348 )
2016
19
Orbital Volume Augmentation for Enophthalmos Following Ventriculoperitoneal Shunting: A Case Study in "Silent Brain Syndrome". ( 26866332 )
2016
20
Enophthalmos and Hemifacial Skeletal Atrophy After Trigeminal Nerve Injury. ( 26784553 )
2016
21
Surgical correction of severe enophthalmos caused by bullet injury. ( 27723646 )
2016
22
Periorbital and Orbital Aging: Senile Enophthalmos as a Cause of Upper Eyelid Ptosis. ( 27348683 )
2016
23
Metastatic Scirrhous Breast Carcinoma to Orbit Causing Enophthalmos. ( 27342331 )
2016
24
The Correlation between the Orbital Volume Ratio and Enophthalmos in Unoperated Blowout Fractures. ( 27896181 )
2016
25
Prostaglandin-Associated Enophthalmos: An Observer-Masked Radiological Study of Patients Treated with Prostaglandin Drops to One Eye Only. ( 26540119 )
2015
26
Posttraumatic Delayed Enophthalmos: Analogies with Silent Sinus Syndrome? Case Report and Literature Review. ( 26269736 )
2015
27
Correction of Late Posttraumatic Enophthalmos Using an Antral Balloon. ( 26080197 )
2015
28
Enophthalmos and choroidal atrophy after intraophthalmic artery chemotherapy for retinoblastoma. ( 25439599 )
2015
29
Acquired enophthalmos with systemic lupus erythematosus. ( 26306741 )
2015
30
Retracting Globe: Enophthalmos and Retraction Due to an Accessory Extraocular Muscle. ( 25714085 )
2015
31
Hyaluronic Acid Gel Re-Injection for Enophthalmos Correction in Silent Sinus Syndrome. ( 26516690 )
2015
32
Pulsatile enophthalmos, severe esotropia, kinked optic nerve and visual loss in neurofibromatosis type-1. ( 26903735 )
2015
33
Association of Titanium Mesh and Bovine Pericardium Membrane in the Treatment of Severe Enophthalmos. ( 26468837 )
2015
34
Retroseptal lipotransfer to correct enophthalmos in the postraumatic amaurotic eye. ( 25415124 )
2014
35
Isolated enophthalmos: an uncommon gateway to orbital tumors in pediatrics: 9 month-old female presenting with isolated enophthalmos as the unique sign of a metastatic orbital tumor: a case report. ( 25248293 )
2014
36
Correction of severe enophthalmos by simultaneous fat grafting and anatomic orbital reconstruction. ( 25203579 )
2014
37
Silent sinus syndrome as a recognised cause of unilateral painless enophthalmos. ( 24859556 )
2014
38
The temporoparietal adipofascial flap for the correction of recurrent idiopathic enophthalmos. ( 24621720 )
2014
39
Titanium screw entered into maxillary sinus: a rare incident during rigid fixation of the porous polyethylene implant in enophthalmos correction. ( 25006927 )
2014
40
Intra-operative navigation for orbital reconstruction to correct diplopia and enophthalmos with endoscopic assisted technique: first case report in Thailand. ( 25536718 )
2014
41
Secondary repair of acquired enophthalmos. ( 24138742 )
2013
42
Enophthalmos as a sign of metastatic breast carcinoma. ( 23460637 )
2013
43
The Correlation between the Degree of Enophthalmos and the Extent of Fracture in Medial Orbital Wall Fracture Left Untreated for Over Six Months: A Retrospective Analysis of 81 Cases at a Single Institution. ( 23898428 )
2013
44
Surgical management of enophthalmos in Duane syndrome. ( 23524730 )
2013
45
The coming age of enophthalmos. ( 23872815 )
2013
46
Swelling of the inferior rectus muscle and enophthalmos in orbital floor fracture. ( 23524790 )
2013
47
Measurement of fracture size using the picture archiving communication system in an outpatient clinic for factors that influence postoperative enophthalmos in adult inferior orbital wall fractures. ( 24036755 )
2013
48
Pulsating enophthalmos in neurofibromatosis 1. ( 23478791 )
2013
49
Correlation between volume of herniated orbital contents and the amount of enophthalmos in orbital floor and wall fractures. ( 21664740 )
2012
50
Enophthalmos following orbital trauma: a diagnostic catch. ( 22872674 )
2012

Variations for Enophthalmos

Expression for Enophthalmos

Search GEO for disease gene expression data for Enophthalmos.

Pathways for Enophthalmos

GO Terms for Enophthalmos

Sources for Enophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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