MCID: ENP001
MIFTS: 28

Enophthalmos malady

Categories: Eye diseases

Aliases & Classifications for Enophthalmos

Aliases & Descriptions for Enophthalmos:

Name: Enophthalmos 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11175
ICD10 33 H05.4 H05.40
ICD9CM 35 376.5 376.50
MeSH 42 D015841
NCIt 47 C79552
UMLS 69 C0014306

Summaries for Enophthalmos

MalaCards based summary : Enophthalmos is related to silent sinus syndrome and horner's syndrome. An important gene associated with Enophthalmos is TFAP2A (Transcription Factor AP-2 Alpha). The drugs Bone Density Conservation Agents and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and breast, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Wikipedia : 71 Enophthalmos is the posterior displacement of the eyeball within the orbit due to changes in the volume... more...

Related Diseases for Enophthalmos

Diseases related to Enophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
id Related Disease Score Top Affiliating Genes
1 silent sinus syndrome 11.2
2 horner's syndrome 11.2
3 neurofibromatosis 10.0
4 sinusitis 9.9
5 maxillary sinusitis 9.8
6 lupus erythematosus 9.8
7 hydrocephalus 9.7
8 chronic maxillary sinusitis 9.7
9 choroiditis 9.7
10 linear scleroderma 9.7
11 facial hemiatrophy 9.6
12 systemic lupus erythematosus 9.6
13 retinoblastoma 9.6
14 tuberculosis 9.6
15 blue rubber bleb nevus 9.6
16 intracranial hypotension 9.6
17 hallermann-streiff syndrome 9.6
18 strabismus 9.6
19 systemic scleroderma 9.6
20 exophthalmos 9.6
21 lymphoma 9.6
22 neurofibroma 9.6
23 ptosis 9.6
24 esotropia 9.6
25 orbit lymphoma 9.6
26 orbital lymphoma 9.6
27 entropion 9.6
28 orbital varix 9.6
29 lagophthalmos 9.6
30 ectropion 9.6
31 bestiality 9.6 CHN1 EPB41L1 FAF2 TFAP2A
32 serous glue ear 8.9 CHN1 CHST3 EPB41L1 FAF2 SASS6 TFAP2A

Graphical network of the top 20 diseases related to Enophthalmos:



Diseases related to Enophthalmos

Symptoms & Phenotypes for Enophthalmos

GenomeRNAi Phenotypes related to Enophthalmos according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.17 TFAP2A EPB41L1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.17 TFAP2A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.17 TFAP2A
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.17 EPB41L1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.17 EPB41L1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.17 EPB41L1

Drugs & Therapeutics for Enophthalmos

Drugs for Enophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Bone Density Conservation Agents Phase 2
2 Calcium, Dietary Phase 2
3
Cocaine Approved, Illicit 50-36-2 5760 446220
4 Anesthetics

Interventional clinical trials:


id Name Status NCT ID Phase
1 Polycaprolactone / Tricalcium Phosphate (PCL/TCP) v Titanium Orbital Implant : Randomised Trial Unknown status NCT01119144 Phase 2
2 Reconstruction of the Orbit With a Bioresorbable Polycaprolactone Implant Completed NCT00233922 Phase 2
3 Use of a Low Profile Titanium Mesh in Orbital Reconstruction Completed NCT01432964

Search NIH Clinical Center for Enophthalmos

Cochrane evidence based reviews: enophthalmos

Genetic Tests for Enophthalmos

Anatomical Context for Enophthalmos

MalaCards organs/tissues related to Enophthalmos:

39
Eye, Bone, Breast, Brain

Publications for Enophthalmos

Articles related to Enophthalmos:

(show top 50) (show all 257)
id Title Authors Year
1
Surgical correction of severe enophthalmos caused by bullet injury. ( 27723646 )
2016
2
Enophthalmos and Hemifacial Skeletal Atrophy After Trigeminal Nerve Injury. ( 26784553 )
2016
3
Metastatic Scirrhous Breast Carcinoma to Orbit Causing Enophthalmos. ( 27342331 )
2016
4
Predicting late enophthalmos: Differences between medial and inferior orbital wall fractures. ( 27769606 )
2016
5
A Straightforward Method of Predicting Enophthalmos in Blowout Fractures Using Enophthalmos Estimate Line. ( 27542546 )
2016
6
Secondary Reconstruction of Residual Enophthalmos Using an Endoscope and Considering the Orbital Floor and Medial Wall Slope. ( 27244206 )
2016
7
Sliced Costochondral Chip Grafts in Posttraumatic Enophthalmos Correction. ( 28027179 )
2016
8
Periorbital and Orbital Aging: Senile Enophthalmos as a Cause of Upper Eyelid Ptosis. ( 27348683 )
2016
9
Antral bony wall erosion, trigeminal nerve injury, and enophthalmos after root canal surgery. ( 27465790 )
2016
10
Prediction of the development of late enophthalmos in pure blowout fractures: delayed orbital tissue atrophy plays a major role. ( 27198642 )
2016
11
The Correlation between the Orbital Volume Ratio and Enophthalmos in Unoperated Blowout Fractures. ( 27896181 )
2016
12
Can customized implants correct enophthalmos and delayed diplopia in post-traumatic orbital deformities? A volumetric analysis. ( 27157630 )
2016
13
Orbital Volume Augmentation for Enophthalmos Following Ventriculoperitoneal Shunting: A Case Study in "Silent Brain Syndrome". ( 26866332 )
2016
14
The imploding antrum: An unusual case of nontraumatic painless enophthalmos. ( 27905348 )
2016
15
Linear scleroderma en coup de sabre presenting with positional diplopia and enophthalmos. ( 27754909 )
2016
16
Association of Titanium Mesh and Bovine Pericardium Membrane in the Treatment of Severe Enophthalmos. ( 26468837 )
2015
17
Acquired enophthalmos with systemic lupus erythematosus. ( 26306741 )
2015
18
Correction of Late Posttraumatic Enophthalmos Using an Antral Balloon. ( 26080197 )
2015
19
Posttraumatic Delayed Enophthalmos: Analogies with Silent Sinus Syndrome? Case Report and Literature Review. ( 26269736 )
2015
20
Enophthalmos and choroidal atrophy after intraophthalmic artery chemotherapy for retinoblastoma. ( 25439599 )
2015
21
Prostaglandin-Associated Enophthalmos: An Observer-Masked Radiological Study of Patients Treated with Prostaglandin Drops to One Eye Only. ( 26540119 )
2015
22
Hyaluronic Acid Gel Re-Injection for Enophthalmos Correction in Silent Sinus Syndrome. ( 26516690 )
2015
23
Pulsatile enophthalmos, severe esotropia, kinked optic nerve and visual loss in neurofibromatosis type-1. ( 26903735 )
2015
24
Retracting Globe: Enophthalmos and Retraction Due to an Accessory Extraocular Muscle. ( 25714085 )
2015
25
Isolated enophthalmos: an uncommon gateway to orbital tumors in pediatrics: 9 month-old female presenting with isolated enophthalmos as the unique sign of a metastatic orbital tumor: a case report. ( 25248293 )
2014
26
The temporoparietal adipofascial flap for the correction of recurrent idiopathic enophthalmos. ( 24621720 )
2014
27
Silent sinus syndrome as a recognised cause of unilateral painless enophthalmos. ( 24859556 )
2014
28
Correction of severe enophthalmos by simultaneous fat grafting and anatomic orbital reconstruction. ( 25203579 )
2014
29
Intra-operative navigation for orbital reconstruction to correct diplopia and enophthalmos with endoscopic assisted technique: first case report in Thailand. ( 25536718 )
2014
30
Retroseptal lipotransfer to correct enophthalmos in the postraumatic amaurotic eye. ( 25415124 )
2014
31
Titanium screw entered into maxillary sinus: a rare incident during rigid fixation of the porous polyethylene implant in enophthalmos correction. ( 25006927 )
2014
32
Swelling of the inferior rectus muscle and enophthalmos in orbital floor fracture. ( 23524790 )
2013
33
The coming age of enophthalmos. ( 23872815 )
2013
34
Pulsating enophthalmos in neurofibromatosis 1. ( 23478791 )
2013
35
The Correlation between the Degree of Enophthalmos and the Extent of Fracture in Medial Orbital Wall Fracture Left Untreated for Over Six Months: A Retrospective Analysis of 81 Cases at a Single Institution. ( 23898428 )
2013
36
Secondary repair of acquired enophthalmos. ( 24138742 )
2013
37
Enophthalmos as a sign of metastatic breast carcinoma. ( 23460637 )
2013
38
Measurement of fracture size using the picture archiving communication system in an outpatient clinic for factors that influence postoperative enophthalmos in adult inferior orbital wall fractures. ( 24036755 )
2013
39
Surgical management of enophthalmos in Duane syndrome. ( 23524730 )
2013
40
Correction of enophthalmos with rib bone segment and diced cartilage grafts. ( 23172443 )
2012
41
Correlation of types of orbital fracture and occurrence of enophthalmos. ( 22777477 )
2012
42
Enophthalmos following orbital trauma: a diagnostic catch. ( 22872674 )
2012
43
Diplopia and enophthalmos in blowout fractures. ( 22777445 )
2012
44
Correlation between volume of herniated orbital contents and the amount of enophthalmos in orbital floor and wall fractures. ( 21664740 )
2012
45
Surgical treatment of enophthalmos using an endoscope and T-shaped porous polyethylene fabricated with a mirror image. ( 22858345 )
2012
46
Correction of posttraumatic enophthalmos. ( 22783485 )
2012
47
Posttraumatic enophthalmos: injuries and outcomes. ( 22777457 )
2012
48
A paradigm shift in correcting medial orbital fracture-related enophthalmos: volumetric augmentation through a lateral approach. ( 22565899 )
2012
49
Orbitozygomatic fractures with enophthalmos: analysis of 64 cases treated late. ( 21752509 )
2012
50
Development and demonstration of a novel computer planning solution for predefined correction of enophthalmos in anophthalmic patients using prebended 3D titanium-meshes--a technical note. ( 23078825 )
2012

Variations for Enophthalmos

Expression for Enophthalmos

Search GEO for disease gene expression data for Enophthalmos.

Pathways for Enophthalmos

GO Terms for Enophthalmos

Sources for Enophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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