MCID: ENT001
MIFTS: 40

Enterocele malady

Categories: Gastrointestinal diseases, Reproductive diseases

Aliases & Classifications for Enterocele

Summaries for Enterocele

MalaCards based summary : Enterocele, also known as vaginal enterocele, is related to congenital diaphragmatic hernia and hiatus hernia. An important gene associated with Enterocele is CD9 (CD9 Molecule), and among its related pathways/superpathways are Cell adhesion_ECM remodeling and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Bupivacaine and Oxycodone have been mentioned in the context of this disorder. Affiliated tissues include small intestine and colon, and related phenotype is Decreased HIV-LTR-beta-galactosidase protein expression.

Wikipedia : 71 An enterocele or enterocoele is a protrusion of the small intestines and peritoneum into the vaginal... more...

Related Diseases for Enterocele

Diseases related to Enterocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
id Related Disease Score Top Affiliating Genes
1 congenital diaphragmatic hernia 12.4
2 hiatus hernia 12.4
3 inguinal hernia 12.3
4 umbilical hernia 12.2
5 diaphragmatic hernia 3 12.0
6 hernia of ovary and fallopian tube 11.8
7 acromegaloid features, overgrowth, cleft palate, and hernia 11.8
8 dandy-walker malformation with nasopharyngeal teratoma and diaphragmatic hernia 11.7
9 spigelian hernia-cryptorchidism syndrome 11.7
10 marfanoid habitus-inguinal hernia-advanced bone age syndrome 11.7
11 lethal hydranencephaly-diaphragmatic hernia syndrome 11.7
12 diverticulosis of bowel, hernia, and retinal detachment 11.7
13 arthrogryposis multiplex with deafness, inguinal hernias, and early death 11.7
14 diaphragmatic hernia exomphalos corpus callosum agenesis 11.7
15 diaphragmatic hernia upper limb defects 11.7
16 hydrocephaly corpus callosum agenesis diaphragmatic hernia 11.7
17 microspherophakia with hernia 11.7
18 dih1-related congenital diaphragmatic hernia 11.7
19 fryns syndrome 11.6
20 donnai-barrow syndrome 11.6
21 shprintzen-goldberg syndrome 11.5
22 short syndrome 11.5
23 galloway-mowat syndrome 11.5
24 abdominal wall defect 11.4
25 persistent mullerian duct syndrome 11.4
26 microphthalmia, syndromic 12 11.4
27 smith-kingsmore syndrome 11.2
28 gershoni-baruch syndrome 11.1
29 vaginitis 10.5
30 ischemic fasciitis 10.1 F2 KLK3
31 autonomic neuropathy 10.1 F2 PVR
32 familial periodic paralysis 10.1 F2 PVR
33 endometrial mixed adenocarcinoma 10.1 F2 KLK3
34 fuchs' heterochromic uveitis 10.1 KLK3 PVR
35 cortical blindness mental retardation polydactyly 10.0 KLK3 MMP13
36 cervicitis 9.8
37 intestinal obstruction 9.8
38 rectal prolapse 9.8
39 solitary rectal ulcer syndrome 9.7
40 endometriosis 9.7
41 peritonitis 9.7
42 intussusception 9.7
43 lymphoma 9.7
44 bladder exstrophy 9.7
45 interstitial cystitis 9.7
46 cystitis 9.7
47 rectal disease 8.6 BRD2 CD9 CMKLR1 ENSG00000278815 F2 KLK3
48 thyroid crisis 8.4 BRD2 CD9 CMKLR1 ENSG00000278815 F2 IDUA

Graphical network of the top 20 diseases related to Enterocele:



Diseases related to Enterocele

Symptoms & Phenotypes for Enterocele

GenomeRNAi Phenotypes related to Enterocele according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HIV-LTR-beta-galactosidase protein expression GR00224-A-1 8.8 CMKLR1 F2 MMP13

Drugs & Therapeutics for Enterocele

Drugs for Enterocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 344)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2180-92-9, 38396-39-3 2474
2
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3 76-42-6 5284603
3
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
4
Ropivacaine Approved Phase 4,Phase 2 84057-95-4 71273 175805
5
Ibuprofen Approved Phase 4,Phase 3 15687-27-1 3672
6
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2 59467-70-8 4192
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 437-38-7 3345
8
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
9
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
10
Acetaminophen Approved Phase 4,Phase 3,Phase 2 103-90-2 1983
11
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 1 137-58-6 3676
12
Levobupivacaine Approved Phase 4,Phase 2 27262-47-1 92253
13
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
14
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3 148553-50-8 5486971
15
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 50-02-2 5743
17
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2 60142-96-3 3446
18
Nitric Oxide Approved Phase 4 10102-43-9 145068
19
Cefazolin Approved Phase 4,Phase 3 25953-19-9 656510 33255
20
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
21
Chloroprocaine Approved Phase 4 133-16-4 8612
22
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
23
Magnesium Sulfate Approved, Vet_approved Phase 4 7487-88-9 24083
24
Clonidine Approved Phase 4,Phase 3,Phase 2 4205-90-7 2803
25
Tizanidine Approved Phase 4 51322-75-9 5487
26
Prilocaine Approved Phase 4 721-50-6 4906
27
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 28523-86-6 5206
28
Tramadol Approved, Investigational Phase 4,Phase 3 27203-92-5 33741
29
Betamethasone Approved, Vet_approved Phase 4,Early Phase 1 378-44-9 9782
30
Remifentanil Approved Phase 4,Phase 3 132875-61-7 60815
31
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
32
Rocuronium Approved Phase 4,Phase 3 119302-91-9, 143558-00-3 441290
33
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
34
Pyrimethamine Approved, Vet_approved Phase 4 58-14-0 4993
35
Sulfadiazine Approved, Vet_approved Phase 4 68-35-9 5215
36
Sulfamethoxazole Approved Phase 4 723-46-6 5329
37
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
38
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
39
Everolimus Approved Phase 4,Phase 3 159351-69-6 6442177
40
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3 22916-47-8 4189
41
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2 128794-94-5 5281078
42
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2 24280-93-1 446541
43
Sirolimus Approved, Investigational Phase 4,Phase 3 53123-88-9 5284616 6436030 46835353
44
Ondansetron Approved Phase 4,Phase 2,Phase 3 99614-02-5 4595
45
Tamsulosin Approved, Investigational Phase 4 106133-20-4 129211
46
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
47
Azathioprine Approved Phase 4 446-86-6 2265
48
Tacrolimus Approved, Investigational Phase 4,Phase 2 104987-11-3 445643 439492
49
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
50
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821

Interventional clinical trials:

(show top 50) (show all 981)
id Name Status NCT ID Phase
1 Rebound Hernia Repair Device Mesh Trial Unknown status NCT00968773 Phase 4
2 Study of Surgical Mesh for Inguinal Hernia Repair Unknown status NCT00924755 Phase 4
3 Comparative Study on Self-adhesive Mesh for Open Inguinal Hernia Repair Unknown status NCT00960011 Phase 4
4 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
5 Usefulness of a Prothetic Absorbable Mesh in Incisional Hernia Prevention After Midline Laparotomy Unknown status NCT02208557 Phase 4
6 A Prospective, Observational Study Utilizing Phasix™ Mesh During Ventral and Incisional Hernia Repair Surgery Unknown status NCT01863030 Phase 4
7 Absorbable Versus Permanent Mesh Fixation Trial in Laparoscopic Midline Ventral Hernia Repair Unknown status NCT01109771 Phase 4
8 Drainage Versus Sealant in Double Blinded Monocentric Open Incisional Hernia Repair Unknown status NCT00775034 Phase 4
9 Functional Outcome After Incisional Hernia Repair: Open Versus Laparoscopic Repair Unknown status NCT00625053 Phase 4
10 Ultrasound-guided Ilioinguinal-iliohypogastric Block for Inguinal Hernia Repair Unknown status NCT01326039 Phase 4
11 Controlled Release of Oxycodone 10 mg In Pre-Medication For The Post Operative Analgesia In Elective Laparoscopic Bilateral Inguinal Hernia And Elective Laparoscopic Cholecystectomy Unknown status NCT00480142 Phase 4
12 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
13 Conservative Versus Aggressive Discectomy for Primary Disc Herniation With Radiculopathy Unknown status NCT01204008 Phase 4
14 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
15 Prophylactic Mesh Implantation After Abdominal Aortic Aneurysm Repair Unknown status NCT01353443 Phase 4
16 Surgical Treatment To Greater Anterior Vaginal Prolapse Unknown status NCT00676325 Phase 4
17 Transvaginal Cholecystectomy Versus Laparoscopic Cholecystectomy in Patients With Biliary Colic Unknown status NCT00963950 Phase 4
18 Ultrasound-guided Transverses Abdominis Plane Block in Inguinal Herniorrhaphy: Randomized Controlled Clinical Trial Unknown status NCT02299908 Phase 4
19 Evaluation of Bone Union Following Anterior Cervical Fusion Using a NovoMax™ Unknown status NCT02425514 Phase 4
20 Comparative Study of Biologic Mesh Versus Repair With Component Separation. Completed NCT01295125 Phase 4
21 A Prospective Study in Patients Undergoing Primary Ventral Hernia Repair Using Parietex™ Composite Ventral Patch Completed NCT01848184 Phase 4
22 Cost- Effectiveness and Cost-utility of Laparoscopic Versus Open Repair of Ventral Hernia Completed NCT01778387 Phase 4
23 Comparing Non-fixation of Mesh to Mesh Fixation in Laparoscopic Inguinal Hernia Repair Completed NCT01117337 Phase 4
24 AbsorbaTack Evaluation of Postoperative Pain Following Laparoscopic Hernia Repair Completed NCT00749268 Phase 4
25 PHS, Lichtenstein Mesh, and PerFixPlug for Primary Inguinal Hernia Repair - 3 Years Results Completed NCT00580177 Phase 4
26 Prevention of Parastomal Hernia With a Mesh Completed NCT00509054 Phase 4
27 Preperitoneal Versus Pre-trasversalis Hernia Repair Completed NCT01350830 Phase 4
28 Strattice in Repair of Inguinal Hernias Completed NCT00681291 Phase 4
29 Prospective Study of the Use of a Mesh to Prevent Parastomal Hernia After Laparoscopic Abdominoperineal Resection Completed NCT01722565 Phase 4
30 Antibiotic Prophylaxis in Mesh Repair of Inguinal Hernias Completed NCT01264003 Phase 4
31 Hernia Prevention. Effectiveness of Reinforced Tension Line (RTL) Technique Compared With the Conventional Method Completed NCT02136628 Phase 4
32 Prospective Randomized Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis Completed NCT00614419 Phase 4
33 Open Mesh Versus Suture Repair in Treatment of Abdominal Wall Hernias Completed NCT01018524 Phase 4
34 Effectiveness of Topical Antibiotic Prophylaxis in Inguinal Hernia Repair Completed NCT01273818 Phase 4
35 Laparoscopic "DA VINCI" Robot Assisted Abdominal Wall Hernia Repair Completed NCT00908193 Phase 4
36 Efficacy Study of Tissucol/Tisseel Fibrin Sealant to Treat Inguinal Hernia Completed NCT00306839 Phase 4
37 Chronic Pain After Inguinal Hernia Repair Completed NCT00820131 Phase 4
38 The Efficacy of Transversus Abdominis Plane Block After Groin Hernia Repair Completed NCT01052285 Phase 4
39 Parietex Progrip Study Completed NCT00827944 Phase 4
40 EXPAREL Infiltrated Into the TAP for Postoperative Analgesia in Unilateral Abdominal Hernia Repair Completed NCT01801124 Phase 4
41 Ultrasound-guided Inguinal Field Block (Genitofemoral, Iliohypogastric and Ilioinguinal Nerve Block) for Inguinal Hernia Surgery Completed NCT01521481 Phase 4
42 Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair Completed NCT02128646 Phase 4
43 Parastomal Reinforcement With Strattice Completed NCT00771407 Phase 4
44 Comparative Study of Safety and Efficacy of Heavyweight and Partially Absorbable Mesh in Inguinal Hernia Repair Completed NCT01877122 Phase 4
45 Intrathecal Morphine for Inguinal Hernia Repair. Completed NCT02001948 Phase 4
46 Comparision of the Use in Marcaine and Chloroprocaine in Rachianesthesia for the Surgical Correction of Inguinal Hernia. Completed NCT02049255 Phase 4
47 Effects of Addition of Magnesium Sulfate in Spinal Anesthesia on Sensory-Motor Blocks and Postoperative Pain in Lumbar Disk Herniation Surgery Completed NCT01843296 Phase 4
48 Barricaid EU Post Market Study for Primary Lumbar Disc Herniation Completed NCT01534065 Phase 4
49 Safety Study of MotifMESH (cPTFE) in Abdominal Surgery Completed NCT01364233 Phase 4
50 Polypropylene Mesh Versus Polytetrafluoroethylene (PTFE) Mesh in Inguinal Hernia Repair Completed NCT01141335 Phase 4

Search NIH Clinical Center for Enterocele

Cochrane evidence based reviews: hernia

Genetic Tests for Enterocele

Anatomical Context for Enterocele

MalaCards organs/tissues related to Enterocele:

39
Small Intestine, Colon

Publications for Enterocele

Articles related to Enterocele:

(show top 50) (show all 130)
id Title Authors Year
1
Robot-assisted versus laparoscopic ventral rectopexy for external, internal rectal prolapse and enterocele: a randomised controlled trial. ( 26919191 )
2016
2
The Manchester-Fothergill and the Elevate PosteriorAr technique for the correction of a cervical elongation and large enterocele in a patient with bladder exstrophy and multiple surgeries. ( 25578871 )
2015
3
Aggressive angiomyxoma of rectovaginal septum, mimicking a huge recto-enterocele: a rare case report. ( 24757344 )
2014
4
Urogynecological prolapse and enterocele are predictive of poor functional outcome after failed or complicated STARR procedures. ( 24691768 )
2014
5
Laparoscopic repair of recurrent lateral enterocele and rectocele. ( 25224146 )
2014
6
[Enterocele containing cecum and terminal ileum at labium majus level]. ( 24094927 )
2013
7
Entero-colpo-defecography vs supine entero-MRI: which one is the best tool in the differentiation of enterocele, elytrocele and edrocele? ( 24152850 )
2013
8
The TRAM dam design: a new method for treatment of an enterocele. ( 22124762 )
2012
9
Enterocele is not a contraindication to stapled transanal surgery for outlet obstruction: an analysis of 170 patients. ( 21564465 )
2011
10
Symptomatic vaginal enterocele associated with malfunctioning ventriculoperitoneal shunt and cerebrospinal ascites. ( 21487828 )
2011
11
Role of enterocele in the obstructed defecation syndrome (ODS): a new radiological point of view. ( 19788492 )
2010
12
Small bowel incarceration associated with posthysterectomy enterocele. ( 19855912 )
2010
13
Laparoscopic correction of enterocele associated to stapled transanal rectal resection for obstructed defecation syndrome. ( 19921222 )
2010
14
Rare cause of intestinal obstruction - Vaginal enterocele. ( 23133218 )
2010
15
Transvaginal pelvic organ prolapse repair of anterior enterocele following cystectomy in females. ( 19089305 )
2009
16
Enterocele--diagnosis and treatment. ( 19200673 )
2009
17
Symptomatic enterocele. An unusual presentation of chylous ascites and lymphoma. ( 18239020 )
2008
18
Rectal prolapse, rectal intussusception, rectocele, solitary rectal ulcer syndrome, and enterocele. ( 18794001 )
2008
19
A comparison of dynamic transperineal ultrasound (DTP-US) with dynamic evacuation proctography (DEP) in the diagnosis of cul de sac hernia (enterocele) in patients with evacuatory dysfunction. ( 18256847 )
2008
20
Enterocele repair by abdominal obliteration of the pelvic inlet: long-term outcome on obstructed defaecation and symptoms of pelvic discomfort. ( 17608820 )
2007
21
Transvaginal repair of enterocele and vaginal vault prolapse using autologous fascia lata graft. ( 16817089 )
2006
22
Laparoscopic vaginal vault suspension and enterocele repair. ( 16920116 )
2006
23
Enterocele: what is the clinical implication? ( 17106819 )
2006
24
Anatomy of the sigmoid colon, rectum, and the rectovaginal pouch in women with enterocele and anterior rectal wall procidentia. ( 16287126 )
2006
25
Obliteration of the pelvic inlet by prophylene mesh and omentoplasty for enterocele. ( 16969606 )
2006
26
Stapled transanal rectal resection under laparoscopic surveillance for rectocele and concomitant enterocele. ( 16583290 )
2006
27
Metastatic colon carcinoma found within an enterocele sac: a case report. ( 15647967 )
2005
28
Bilateral iliococcygeal fixation for vaginal vault prolapse and enterocele repair using a new suturing device--the digital needle driver. ( 16045532 )
2005
29
Enterocele associated with rectocele revealed by dynamic pelvic CT. ( 15803223 )
2005
30
Posterior compartment prolapse on two-dimensional and three-dimensional pelvic floor ultrasound: the distinction between true rectocele, perineal hypermobility and enterocele. ( 15973648 )
2005
31
Severe intra-abdominal bleeding following stapled mucosectomy due to enterocele: report of a case. ( 15057589 )
2004
32
Transection of a colonic diverticulum during enterocele repair. ( 15663145 )
2004
33
Anterior enterocele: a report of three cases. ( 15278250 )
2004
34
Laparoscopic treatment of enterocele: a 3-year evaluation. ( 15089832 )
2004
35
The pathophysiology of an enterocele and its management. ( 15203582 )
2004
36
Commentary on: "Posterior culdeplasty: surgical correction of enterocele during vaginal hysterectomy: A preliminary report". 1957. ( 12681861 )
2003
37
Diagnosis of posterior enterocele: comparison of rectal ultrasonography with intraoperative diagnosis. ( 11934095 )
2002
38
Treatment of enterocele by abdominal colporectosacropexy - efficacy on pelvic pressure. ( 12780575 )
2002
39
Combined abdominoperineal repair of enterocele and rectocele. ( 11862573 )
2001
40
Vaginal vault fixation and prevention of enterocele recurrence by high midline levator myorraphy: physical examination and questionnaire-based follow-up. ( 11805411 )
2001
41
High uterosacral vaginal vault suspension with fascial reconstruction for vaginal repair of enterocele and vaginal vault prolapse. ( 11744906 )
2001
42
Functional and anatomic follow-up of enterocele repairs. ( 11506843 )
2001
43
Enterocele: is there a histologic defect? ( 11576580 )
2001
44
Vaginal vault suspension and enterocele repair by Richardson-Saye laparoscopic technique: description of training technique and results. ( 11303992 )
2001
45
Repair of enterocele and vault prolapse: transvaginal culdosuspension. ( 11383993 )
2001
46
Enterocele repair and vaginal vault suspension. ( 10954154 )
2000
47
Treatment of enterocele by obliteration of the pelvic inlet. ( 10813137 )
2000
48
Abdominal sacral colpopexy and abdominal enterocele repair in the management of vaginal vault prolapse. ( 11114564 )
2000
49
Clinical presentation of enterocele. ( 11004366 )
2000
50
Laparoscopic surgery for enterocele, vaginal apex prolapse and rectocele. ( 10450821 )
1999

Variations for Enterocele

Expression for Enterocele

Search GEO for disease gene expression data for Enterocele.

Pathways for Enterocele

Pathways related to Enterocele according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.74 KLK3 MMP13
2 9.95 F2 KLK3

GO Terms for Enterocele

Cellular components related to Enterocele according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CD9 F2 KLK3 MMP13 PVR

Biological processes related to Enterocele according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of fat cell differentiation GO:0045600 8.96 CMKLR1 WDFY2
2 cellular protein metabolic process GO:0044267 8.8 F2 KLK3 MMP13

Molecular functions related to Enterocele according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 F2 KLK3 MMP13

Sources for Enterocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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