MCID: ENT007
MIFTS: 27

Enteropathica malady

Gastrointestinal diseases category

Summaries for Enteropathica

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Acrodermatitis enteropathica is an autosomal recessivemetabolic disorder affecting the uptake of zinc,... more...

MalaCards: Enteropathica is related to acrodermatitis enteropathica and acrodermatitis. An important gene associated with Enteropathica is SLC39A4 (solute carrier family 39 (zinc transporter), member 4), and among its related pathways are Senescence and Autophagy and NAD metabolism. The compounds Fospropofol and phosphoethanolamine have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and growth/size.

Aliases & Classifications for Enteropathica

About this section
Sources:
42NIH Rare Diseases
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

enteropathica 42


Related Diseases for Enteropathica

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Enteropathica via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1acrodermatitis enteropathica31.7SLC30A4, SLC30A5, SLC39A1, SLC39A5, SLC39A4
2acrodermatitis31.7SLC39A4
3cystic fibrosis30.5OTC, ALB
4diarrhea30.1ALB, ALPPL2, ALPP, ALPL
5pancreatitis30.0ALB, ALPP, ALPL, ALPPL2
6dermatitis10.2
7anorexia nervosa10.2
8maple syrup urine disease10.0
9lactose intolerance10.0
10acute leukemia10.0
11acute lymphocytic leukemia10.0
12leukemia10.0
13optic atrophy10.0
14biliary atresia10.0OTC
15lung cancer10.0ALB
16arthropathy10.0ALPL
17dysgerminoma10.0ALPP
18acute liver failure10.0OTC, ALB
19liver cirrhosis10.0ALB
20choriocarcinoma10.0ALPPL2, ALPP
21hypophosphatasia, infantile10.0ALPL, ALPP
22endodermal sinus tumor10.0ALPP, ALPPL2
23choledocholithiasis10.0ALPP, ALPPL2, ALPL
24hyperphosphatemia10.0ALPPL2, ALPP, ALPL
25hypophosphatemia10.0ALPPL2, ALPP, ALPL
26osteitis fibrosa10.0ALPPL2, ALPP, ALPL
27hypophosphatasia10.0ALPL, ALPPL2, ALPP
28x-linked hypophosphatemia10.0ALPPL2, ALPL, ALPP
29embryonal cancer10.0ALPP, ALPPL2, ALPL
30osteosclerosis10.0ALPPL2, ALPL, ALPP
31fibrous dysplasia10.0ALPPL2, ALPP, ALPL
32renal osteodystrophy10.0ALPPL2, ALPP, ALPL
33calcinosis10.0ALPPL2, ALPL, ALPP
34hyperthyroidism10.0ALPP, ALPPL2, ALPL
35vascular disease10.0ALPL, ALPP, ALPPL2
36osteomalacia10.0ALPPL2, ALPL, ALPP
37osteogenesis imperfecta10.0ALPP, ALPL, ALPPL2
38parathyroid adenoma10.0ALPPL2, ALPP, ALPL
39paget's disease of bone10.0ALPP, ALPL, ALPPL2
40periodontal disease10.0ALPPL2, ALPP, ALPL
41rickets10.0ALB, ALPP
42cholelithiasis10.0ALPL, ALPP, ALPPL2
43osteonecrosis10.0ALPPL2, ALPP, ALPL
44teratoma10.0ALPP, ALPPL2, ALPL
45cholangiocarcinoma10.0ALPPL2, ALPL, ALPP
46bilirubin metabolic disorder10.0ALB, ALPP, ALPL, ALPPL2
47cork-handlers' disease10.0ALB, ALPPL2, ALPP, ALPL
48primary hyperoxaluria10.0ALB, ALPL, ALPP, ALPPL2
49hypercalcemia10.0ALB, ALPP, ALPL, ALPPL2
50cholangitis10.0ALPL, ALPPL2, ALPP, ALB

Graphical network of the top 20 diseases related to Enteropathica:



Diseases related to enteropathica

Clinical Features for Enteropathica

About this section

Drugs & Therapeutics for Enteropathica

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Enteropathica

Drug clinical trials:

Search ClinicalTrials for Enteropathica

Search NIH Clinical Center for Enteropathica

Search CenterWatch for Enteropathica

Genetic Tests for Enteropathica

About this section

Anatomical Context for Enteropathica

About this section

Animal Models for Enteropathica or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Enteropathica:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.6SLC39A1, SLC39A14, SLC39A2, TMPO, ALPL, SLC30A5
2MP:00053786.2ALPP, PLIN2, SLC30A5, SLC39A1, SLC30A7, SLC39A14

Publications for Enteropathica

About this section

Genetic Variations for Enteropathica

About this section

Expression for genes affiliated with Enteropathica

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Enteropathica

Search GEO for disease gene expression data for Enteropathica.

Pathways for genes affiliated with Enteropathica

About this section
Sources:
37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 53Reactome
See all sources

Compounds for genes affiliated with Enteropathica

About this section
Sources:
11DrugBank, 44Novoseek, 24HMDB
See all sources

Compounds related to Enteropathica according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1Fospropofol1110.2ALB, ALPL
2phosphoethanolamine449.8ALPP, ALPL
37,8-dihydroneopterin44 2410.7ALPPL2, ALPP, ALPL
4diflunisal44 1110.7ALB, ALPP
5sevoflurane44 1110.7ALB, ALPP
6dihydroneopterin triphosphate44 2410.7ALPL, ALPP, ALPPL2
7dihydroxyacetone44 2410.7ALPL, ALPP, ALPPL2
8vitamin b6449.7ALPL, ALPP, ALB
9amifostine44 1110.6ALPPL2, ALPL
10levamisole44 1110.6ALPPL2, ALPP, ALPL
11alizarin449.6ALPL, ALPP
12pyridoxal 5-phosphate449.6ALB, ALPP, ALPL
13aspartate449.1OTC, TMPO, ALPL, ALPP, ALB
14zinc44 249.8SLC30A5, SLC39A1, SLC30A2, SLC30A1, SLC39A2, SLC30A4

GO Terms for genes affiliated with Enteropathica

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Enteropathica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic membrane-bounded vesicleGO:0160239.2SLC39A4, SLC39A2, SLC30A7
2anchored to membraneGO:0312259.1ALPL, ALPP, ALPPL2
3plasma membraneGO:0058866.8PLIN2, SLC39A1, SLC39A8, SLC30A1, SLC39A14, SLC39A2
4integral to membraneGO:0160215.5ALPP, SLC39A1, SLC39A8, SLC30A2, SLC30A1, SLC30A7

Biological processes related to Enteropathica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to zinc ionGO:01004310.0OTC, SLC30A5
2cellular response to zinc ion starvationGO:0342249.8SLC39A4, SLC39A5
3cellular zinc ion homeostasisGO:0068829.2SLC30A5, SLC30A1, SLC39A14, SLC39A4
4zinc ion transmembrane transportGO:0715779.1SLC30A5, SLC39A1, SLC39A14, SLC30A4
5zinc ion transportGO:0068298.0SLC39A5, SLC39A2, SLC30A7, SLC30A1, SLC30A2, SLC39A8
6transmembrane transportGO:0550856.1ALB, SLC30A5, SLC39A1, SLC39A8, SLC39A4, SLC39A5

Molecular functions related to Enteropathica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metal ion transmembrane transporter activityGO:0468739.5SLC39A5, SLC39A8
2cation transmembrane transporter activityGO:0083249.5SLC30A7, SLC30A2
3alkaline phosphatase activityGO:0040359.3ALPL, ALPP, ALPPL2
4zinc ion transmembrane transporter activityGO:0053857.7SLC39A4, SLC30A5, SLC39A1, SLC30A1, SLC39A14, SLC30A6

Products for genes affiliated with Enteropathica

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Enteropathica

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet