MCID: ENT007
MIFTS: 26

Enteropathica malady

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Enteropathica

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Aliases & Descriptions for Enteropathica:

Name: Enteropathica 46

Classifications:



Summaries for Enteropathica

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MalaCards based summary: Enteropathica is related to acrodermatitis enteropathica and acrodermatitis. An important gene associated with Enteropathica is SLC39A4 (Solute Carrier Family 39 Member 4). Affiliated tissues include breast, skin and eye, and related mouse phenotypes are obsolete other and liver/biliary system.

Related Diseases for Enteropathica

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Graphical network of the top 20 diseases related to Enteropathica:



Diseases related to enteropathica

Symptoms for Enteropathica

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Drugs & Therapeutics for Enteropathica

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Drugs for Enteropathica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Zinc21547440-66-632051, 23994
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+

Interventional clinical trials:

idNameStatusNCT IDPhase
1Genetic Study of Severe Zinc DeficienciesCompletedNCT02870166

Search NIH Clinical Center for Enteropathica

Genetic Tests for Enteropathica

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Anatomical Context for Enteropathica

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MalaCards organs/tissues related to Enteropathica:

34
Breast, Skin, Eye, Liver, Colon, Pancreas

Animal Models for Enteropathica or affiliated genes

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MGI Mouse Phenotypes related to Enteropathica:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539510.0SLC30A4, SLC39A4
2MP:00053708.4ALB, OTC, PLIN2, SLC39A4
3MP:00053767.5ALB, OTC, PLIN2, SLC30A4, SLC39A4
4MP:00053797.2ALB, OTC, PLIN2, SLC30A4, SLC39A4

Publications for Enteropathica

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Articles related to Enteropathica:

(show top 50)    (show all 359)
idTitleAuthorsYear
1
Acquired acrodermatitis enteropathica as a presenting sign of celiac disease. (27222886)
2016
2
Acrodermatitis enteropathica-like skin lesions in a neonate. (23814231)
2013
3
A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. (22737083)
2012
4
Gray hair and acrodermatitis enteropathica-like dermatitis: an unexpected presentation of cystic fibrosis. (21424670)
2011
5
Acrodermatitis enteropathica: a review of 29 Tunisian cases. (20883266)
2010
6
Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations. (18936158)
2009
7
Acrodermatitis enteropathica in a full-term exclusively breast-fed infant. (18424385)
2008
8
Acrodermatitis enteropathica-like simulating severe atopic dermatitis: a case report. (18680706)
2008
9
What is your diagnosis? Acquired acrodermatitis enteropathica. (18491477)
2008
10
Identification of a unique splice site variant in SLC39A4 in bovine hereditary zinc deficiency, lethal trait A46: An animal model of acrodermatitis enteropathica. (16714095)
2006
11
Acrodermatitis enteropathica: zinc therapy and possible identification of a carrier state through multiple hair zinc analyses over three decades. (17205991)
2006
12
Acrodermatitis enteropathica-like eruption associated with combined nutritional deficiency. (16224175)
2005
13
Acrodermatitis enteropathica-like eruption and food allergy. (15801253)
2005
14
Mutation spectrum of human SLC39A4 in a panel of patients with acrodermatitis enteropathica. (12955721)
2003
15
Acrodermatitis enteropathica - lifelong follow-up and zinc monitoring. (11952674)
2002
16
The acrodermatitis enteropathica mutation transiently affects zinc metabolism in human fibroblasts. (8558304)
1996
17
Acrodermatitis enteropathica-like eruption during treatment of maple syrup urine disease: report of one case. (8942030)
1996
18
Zinc transport by fibroblasts from patients with acrodermatitis enteropathica. (2484411)
1989
19
Clinical and laboratory diagnosis of acrodermatitis enteropathica. (2691254)
1989
20
Long chain fatty acids in serum phospholipids in acrodermatitis enteropathica before and after zinc treatment: a case report. (3392358)
1988
21
Picolinic acid in acrodermatitis enteropathica: evidence for a disorder of tryptophan metabolism. (6694049)
1984
22
Serum and hair zinc as predictors of clinical symptoms in acrodermatitis enteropathica. (6429442)
1984
23
Maternal essential fatty acid supplementation increases zinc absorption in neonatal rats: relevance to the defect in zinc absorption in acrodermatitis enteropathica. (7110781)
1982
24
Acquired acrodermatitis enteropathica. (6786834)
1981
25
Zinc therapy of depressed cellular immunity in acrodermatitis enteropathica. (7301208)
1981
26
Is acrodermatitis enteropathica related to the absence of zinc binding ligand in bovine milk? (570352)
1979
27
The acrodermatitis enteropathica-like syndrome. (109049)
1979
28
Acrodermatitis enteropathica--a zinc deficiency state. (675401)
1978
29
Acrodermatitis enteropathica, zinc and human milk. (692949)
1978
30
Acrodermatitis enteropathica induced by iatrogenic zinc deficiency. (103205)
1978
31
Acrodermatitis enteropathica without hypozincemia. (894428)
1977
32
Gluconate zinc in acrodermatitis enteropathica. (773310)
1976
33
Letter: Acrodermatitis enteropathica and cellular immune deficiency. (57499)
1976
34
Treatment of acrodermatitis enteropathica with zinc sulfate. (776091)
1976
35
Reversible intestinal mucosal abnormality in acrodermatitis enteropathica. (952555)
1976
36
Letter: Exacerbation of acrodermatitis enteropathica by soya-bean milk feeding. (52794)
1975
37
Acrodermatitis enteropathica. Corneal involvement with histochemical and electron micrographic studies. (124566)
1975
38
Tryptophan metabolsim and serum fatty acids in acrodermatitis enteropathica. (4407531)
1974
39
Ultrastructural findings in acrodermatitis enteropathica. (4359206)
1974
40
Agammaglobulinemia with B lymphocytes in a neonate with acrodermatitis enteropathica. (4546718)
1974
41
Serum fatty acids before and after recovery from acrodermatitis enteropathica: comparison of an infant with her family. (4757538)
1973
42
Presence of -lipoprotein in serum of patients treated for acrodermatitis enteropathica (Danbolt's disease). (4343518)
1972
43
Case for diagnosis: acrodermatitis enteropathica vs sebopsoriasis. (4248273)
1970
44
Acrodermatitis enteropathica. (5823853)
1969
45
Acrodermatitis enteropathica. Report of a case in a twin with dramatic response to expressed human milk. (5318960)
1965
46
Eye symptoms in Acromdermatitis enteropathica. A description of a brother and sister, with corneal changes. (14001285)
1962
47
Acrodermatitis enteropathica? ulcerative colitis--progeroid physiognomy. (14005379)
1962
48
Acrodermatitis enteropathica without diarrhea. (13737316)
1961
49
Acrodermatitis enteropathica. (13322929)
1956
50
Acrodermatitis enteropathica; report of two additional cases. (18101569)
1948

Variations for Enteropathica

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Expression for genes affiliated with Enteropathica

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Search GEO for disease gene expression data for Enteropathica.

Pathways for genes affiliated with Enteropathica

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GO Terms for genes affiliated with Enteropathica

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Cellular components related to Enteropathica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmic, membrane-bounded vesicleGO:00160239.5SLC30A4, SLC39A4

Biological processes related to Enteropathica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to zinc ionGO:00100439.3OTC, SLC30A4

Molecular functions related to Enteropathica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1zinc ion transmembrane transporter activityGO:00053859.5SLC30A4, SLC39A4

Sources for Enteropathica

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet