MCID: ENT007
MIFTS: 31

Enteropathica malady

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Enteropathica

Aliases & Descriptions for Enteropathica:

Name: Enteropathica 50

Classifications:



Summaries for Enteropathica

MalaCards based summary : Enteropathica is related to acrodermatitis enteropathica and acrodermatitis. An important gene associated with Enteropathica is SLC39A4 (Solute Carrier Family 39 Member 4), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. The drug Zinc has been mentioned in the context of this disorder. Affiliated tissues include breast, skin and eye, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Enteropathica

Graphical network of the top 20 diseases related to Enteropathica:



Diseases related to Enteropathica

Symptoms & Phenotypes for Enteropathica

MGI Mouse Phenotypes related to Enteropathica:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.73 SLC39A5 ALB OTC PLIN2 SLC30A4 SLC39A4
2 homeostasis/metabolism MP:0005376 9.63 ALB OTC PLIN2 SLC30A4 SLC39A4 SLC39A5
3 liver/biliary system MP:0005370 9.35 ALB OTC PLIN2 SLC39A4 SLC39A5
4 obsolete other MP:0005395 8.62 SLC30A4 SLC39A4

Drugs & Therapeutics for Enteropathica

Drugs for Enteropathica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved 7440-66-6 32051 23994

Interventional clinical trials:


id Name Status NCT ID Phase
1 Genetic Study of Severe Zinc Deficiencies Completed NCT02870166

Search NIH Clinical Center for Enteropathica

Genetic Tests for Enteropathica

Anatomical Context for Enteropathica

MalaCards organs/tissues related to Enteropathica:

39
Breast, Skin, Eye, Liver, Kidney, Colon, Pancreas

Publications for Enteropathica

Articles related to Enteropathica:

(show top 50) (show all 366)
id Title Authors Year
1
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. ( 28056538 )
2017
2
Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report. ( 28340843 )
2017
3
Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report. ( 28521835 )
2017
4
First report of SLC39A4 mutation in acrodermatitis enteropathica family from the Middle East. ( 28188634 )
2017
5
An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis. ( 27940220 )
2016
6
Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica. ( 27567652 )
2016
7
Acrodermatitis enteropathica in a pair of twins. ( 28435477 )
2016
8
Acrodermatitis enteropathica: A novel mutation of the SLC39A4 gene in a Turkish boy. ( 26916651 )
2016
9
Acquired acrodermatitis enteropathica after gastric bypass surgery responsive to IV supplementation. ( 28329567 )
2016
10
Acrodermatitis Enteropathica: A Case Report. ( 27196457 )
2016
11
Acquired acrodermatitis enteropathica as a presenting sign of celiac disease. ( 27222886 )
2016
12
Severe acquired acrodermatitis enteropathica caused by anorexia nervosa. ( 26661624 )
2016
13
Acrodermatitis enteropathica in an adult. ( 26244999 )
2015
14
Bullous acrodermatitis enteropathica: case report of a unique clinical presentation and review of the literature. ( 25933075 )
2015
15
Genetic causes and genea89nutrient interactions in mammalian zinc deficiencies: acrodermatitis enteropathica and transient neonatal zinc deficiency as examples. ( 25468189 )
2015
16
Acrodermatitis Enteropathica: A Novel SLC39A4 Gene Mutation in a Patient with Normal Zinc Levels. ( 25780817 )
2015
17
Celiac Disease Presenting With Acquired Acrodermatitis Enteropathica. ( 26465901 )
2015
18
Phrynoderm und erworbene Acrodermatitis enteropathica bei stillenden Frauen nach bariatrischer Chirurgie. ( 26513074 )
2015
19
Acrodermatitis enteropathica in an infant with normal zinc levels. ( 25566908 )
2015
20
Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. ( 26513075 )
2015
21
Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas). ( 26051055 )
2015
22
Clinical utility gene card for: acrodermatitis enteropathica - update 2015. ( 26443269 )
2015
23
Identification of a Novel Mutation in the SLC39A4 Gene in a Case of Acrodermatitis Enteropathica. ( 26351177 )
2015
24
Development of a plasma zinc concentration cutoff to identify individuals with severe zinc deficiency based on results from adults undergoing experimental severe dietary zinc restriction and individuals with acrodermatitis enteropathica. ( 24850624 )
2014
25
Cow's Milk Protein Allergy Mimicking Acrodermatitis Enteropathica. ( 24783119 )
2014
26
One recurrent homozygous mutation of SLC39A4 in a girl with acrodermatitis enteropathica from southwestern China. ( 24962159 )
2014
27
Images in clinical medicine. Acquired acrodermatitis enteropathica. ( 24988559 )
2014
28
Secondary acrodermatitis enteropathica-like lesions in a child with newly diagnosed coeliac disease. ( 25540873 )
2014
29
Images in emergency medicine. Child with diarrhea and rash. Acrodermatitis enteropathica. ( 24054094 )
2013
30
Transient symptomatic zinc deficiency resembling acrodermatitis enteropathica in a breast-fed premature infant: case report and brief review of the literature. ( 24442054 )
2013
31
Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathica. ( 24015258 )
2013
32
Periorificial dermatitis and erosive inguinal plaques in a 57-year-old woman. Acquired zinc deficiency acrodermatitis enteropathica (ADE). ( 23552816 )
2013
33
Acrodermatitis enteropathica-like skin lesions in a neonate. ( 23814231 )
2013
34
Acrodermatitis enteropathica in three siblings. ( 23442482 )
2013
35
Acrodermatitis enteropathica. ( 22486149 )
2012
36
Clinical utility gene card for: acrodermatitis enteropathica. ( 22166942 )
2012
37
A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. ( 22737083 )
2012
38
Think zinc deficiency: acquired acrodermatitis enteropathica due to poor diet and common medications. ( 22911205 )
2012
39
A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene. ( 23430849 )
2012
40
Acrodermatitis enteropathica during adequate enteral nutrition. ( 22038206 )
2012
41
Two compound heterozygous novel SLC39A4 mutations in generalized eczematoid acrodermatitis enteropathica. ( 23228939 )
2012
42
Acrodermatitis enteropathica: a novel SLC39A4 gene mutation found in a patient with an early-onset. ( 21906148 )
2011
43
Acrodermatitis enteropathica variant with borderline plasma zinc concentrations. ( 21502834 )
2011
44
Novel SLC39A4 mutation in acrodermatitis enteropathica. ( 22082465 )
2011
45
Development of Bullous Acrodermatitis Enteropathica during the Course of Chemotherapy for Acute Lymphocytic Leukemia. ( 22346269 )
2011
46
A case of acrodermatitis enteropathica localized on the hands and feet with a normal serum zinc level. ( 22028583 )
2011
47
Gray hair and acrodermatitis enteropathica-like dermatitis: an unexpected presentation of cystic fibrosis. ( 21424670 )
2011
48
Acrodermatitis enteropathica in a 9 month old infant. ( 21598821 )
2011
49
Acrodermatitis enteropathica: an uncommon differential diagnosis in childhood - first description of a new sequence variant. ( 21762381 )
2011
50
One novel homozygous mutation of SLC39A4 gene in a Chinese patient with acrodermatitis enteropathica. ( 20300938 )
2010

Variations for Enteropathica

Expression for Enteropathica

Search GEO for disease gene expression data for Enteropathica.

Pathways for Enteropathica

GO Terms for Enteropathica

Cellular components related to Enteropathica according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 late endosome GO:0005770 8.62 SLC30A2 SLC30A4

Biological processes related to Enteropathica according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 transport GO:0006810 9.88 ALB SLC30A2 SLC30A4 SLC39A4 SLC39A5
2 ion transport GO:0006811 9.73 SLC30A2 SLC30A4 SLC39A4 SLC39A5
3 transmembrane transport GO:0055085 9.67 SLC30A2 SLC30A4 SLC39A4 SLC39A5
4 cation transmembrane transport GO:0098655 9.51 SLC30A2 SLC30A4
5 cation transport GO:0006812 9.49 SLC30A2 SLC30A4
6 metal ion transport GO:0030001 9.46 SLC39A4 SLC39A5
7 zinc II ion transmembrane transport GO:0071577 9.4 SLC30A2 SLC30A4
8 cellular zinc ion homeostasis GO:0006882 9.32 SLC39A4 SLC39A5
9 zinc II ion transmembrane import GO:0071578 9.26 SLC39A4 SLC39A5
10 cellular response to zinc ion starvation GO:0034224 9.16 SLC39A4 SLC39A5
11 response to zinc ion GO:0010043 9.13 OTC SLC30A2 SLC30A4
12 zinc II ion transport GO:0006829 8.92 SLC30A2 SLC30A4 SLC39A4 SLC39A5

Molecular functions related to Enteropathica according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cation transmembrane transporter activity GO:0008324 9.16 SLC30A2 SLC30A4
2 metal ion transmembrane transporter activity GO:0046873 8.96 SLC39A4 SLC39A5
3 zinc ion transmembrane transporter activity GO:0005385 8.92 SLC30A2 SLC30A4 SLC39A4 SLC39A5

Sources for Enteropathica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....