MCID: ENT007
MIFTS: 31

Enteropathica malady

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Enteropathica

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Aliases & Descriptions for Enteropathica:

Name: Enteropathica 48

Classifications:



Summaries for Enteropathica

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MalaCards based summary: Enteropathica is related to acrodermatitis enteropathica and acrodermatitis. An important gene associated with Enteropathica is SLC39A4 (Solute Carrier Family 39 Member 4), and among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. Affiliated tissues include breast, skin and eye, and related mouse phenotypes are obsolete other and liver/biliary system.

Related Diseases for Enteropathica

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Graphical network of the top 20 diseases related to Enteropathica:



Diseases related to enteropathica

Symptoms & Phenotypes for Enteropathica

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MGI Mouse Phenotypes related to Enteropathica according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.6SLC30A4, SLC39A4
2MP:00053708.4ALB, OTC, PLIN2, SLC39A4, SLC39A5
3MP:00053798.2ALB, OTC, PLIN2, SLC30A4, SLC39A4, SLC39A5
4MP:00053768.1ALB, OTC, PLIN2, SLC30A4, SLC39A4, SLC39A5

Drugs & Therapeutics for Enteropathica

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Drugs for Enteropathica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Zincapproved22967440-66-632051, 23994
Synonyms:
30Zn
Cinc
Zinc
Zinc ion
 
Zincum
Zink
Zn
Zn(ii)
Zn2+

Interventional clinical trials:

idNameStatusNCT IDPhase
1Genetic Study of Severe Zinc DeficienciesCompletedNCT02870166

Search NIH Clinical Center for Enteropathica

Genetic Tests for Enteropathica

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Anatomical Context for Enteropathica

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MalaCards organs/tissues related to Enteropathica:

36
Breast, Skin, Eye, Pancreas, Liver, Colon, Kidney

Publications for Enteropathica

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Articles related to Enteropathica:

(show top 50)    (show all 366)
idTitleAuthorsYear
1
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. (28056538)
2017
2
Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report. (28340843)
2017
3
Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report. (28521835)
2017
4
First report of SLC39A4 mutation in acrodermatitis enteropathica family from the Middle East. (28188634)
2017
5
An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis. (27940220)
2016
6
Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica. (27567652)
2016
7
Acrodermatitis enteropathica in a pair of twins. (28435477)
2016
8
Acrodermatitis enteropathica: A novel mutation of the SLC39A4 gene in a Turkish boy. (26916651)
2016
9
Acquired acrodermatitis enteropathica after gastric bypass surgery responsive to IV supplementation. (28329567)
2016
10
Acrodermatitis Enteropathica: A Case Report. (27196457)
2016
11
Acquired acrodermatitis enteropathica as a presenting sign of celiac disease. (27222886)
2016
12
Severe acquired acrodermatitis enteropathica caused by anorexia nervosa. (26661624)
2016
13
Acrodermatitis enteropathica in an adult. (26244999)
2015
14
Bullous acrodermatitis enteropathica: case report of a unique clinical presentation and review of the literature. (25933075)
2015
15
Genetic causes and genea89nutrient interactions in mammalian zinc deficiencies: acrodermatitis enteropathica and transient neonatal zinc deficiency as examples. (25468189)
2015
16
Acrodermatitis Enteropathica: A Novel SLC39A4 Gene Mutation in a Patient with Normal Zinc Levels. (25780817)
2015
17
Celiac Disease Presenting With Acquired Acrodermatitis Enteropathica. (26465901)
2015
18
Phrynoderm und erworbene Acrodermatitis enteropathica bei stillenden Frauen nach bariatrischer Chirurgie. (26513074)
2015
19
Acrodermatitis enteropathica in an infant with normal zinc levels. (25566908)
2015
20
Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. (26513075)
2015
21
Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas). (26051055)
2015
22
Clinical utility gene card for: acrodermatitis enteropathica - update 2015. (26443269)
2015
23
Identification of a Novel Mutation in the SLC39A4 Gene in a Case of Acrodermatitis Enteropathica. (26351177)
2015
24
Development of a plasma zinc concentration cutoff to identify individuals with severe zinc deficiency based on results from adults undergoing experimental severe dietary zinc restriction and individuals with acrodermatitis enteropathica. (24850624)
2014
25
Cow's Milk Protein Allergy Mimicking Acrodermatitis Enteropathica. (24783119)
2014
26
One recurrent homozygous mutation of SLC39A4 in a girl with acrodermatitis enteropathica from southwestern China. (24962159)
2014
27
Images in clinical medicine. Acquired acrodermatitis enteropathica. (24988559)
2014
28
Secondary acrodermatitis enteropathica-like lesions in a child with newly diagnosed coeliac disease. (25540873)
2014
29
Images in emergency medicine. Child with diarrhea and rash. Acrodermatitis enteropathica. (24054094)
2013
30
Transient symptomatic zinc deficiency resembling acrodermatitis enteropathica in a breast-fed premature infant: case report and brief review of the literature. (24442054)
2013
31
Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathica. (24015258)
2013
32
Periorificial dermatitis and erosive inguinal plaques in a 57-year-old woman. Acquired zinc deficiency acrodermatitis enteropathica (ADE). (23552816)
2013
33
Acrodermatitis enteropathica-like skin lesions in a neonate. (23814231)
2013
34
Acrodermatitis enteropathica in three siblings. (23442482)
2013
35
Acrodermatitis enteropathica. (22486149)
2012
36
Clinical utility gene card for: acrodermatitis enteropathica. (22166942)
2012
37
A mouse model of acrodermatitis enteropathica: loss of intestine zinc transporter ZIP4 (Slc39a4) disrupts the stem cell niche and intestine integrity. (22737083)
2012
38
Think zinc deficiency: acquired acrodermatitis enteropathica due to poor diet and common medications. (22911205)
2012
39
A Zinc Sulphate-Resistant Acrodermatitis Enteropathica Patient with a Novel Mutation in SLC39A4 Gene. (23430849)
2012
40
Acrodermatitis enteropathica during adequate enteral nutrition. (22038206)
2012
41
Two compound heterozygous novel SLC39A4 mutations in generalized eczematoid acrodermatitis enteropathica. (23228939)
2012
42
Acrodermatitis enteropathica: a novel SLC39A4 gene mutation found in a patient with an early-onset. (21906148)
2011
43
Acrodermatitis enteropathica variant with borderline plasma zinc concentrations. (21502834)
2011
44
Novel SLC39A4 mutation in acrodermatitis enteropathica. (22082465)
2011
45
Development of Bullous Acrodermatitis Enteropathica during the Course of Chemotherapy for Acute Lymphocytic Leukemia. (22346269)
2011
46
A case of acrodermatitis enteropathica localized on the hands and feet with a normal serum zinc level. (22028583)
2011
47
Gray hair and acrodermatitis enteropathica-like dermatitis: an unexpected presentation of cystic fibrosis. (21424670)
2011
48
Acrodermatitis enteropathica in a 9 month old infant. (21598821)
2011
49
Acrodermatitis enteropathica: an uncommon differential diagnosis in childhood - first description of a new sequence variant. (21762381)
2011
50
One novel homozygous mutation of SLC39A4 gene in a Chinese patient with acrodermatitis enteropathica. (20300938)
2010

Variations for Enteropathica

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Expression for genes affiliated with Enteropathica

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Search GEO for disease gene expression data for Enteropathica.

Pathways for genes affiliated with Enteropathica

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GO Terms for genes affiliated with Enteropathica

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Cellular components related to Enteropathica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1late endosomeGO:00057709.3SLC30A2, SLC30A4

Biological processes related to Enteropathica according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cation transmembrane transportGO:009865510.1SLC30A2, SLC30A4
2cation transportGO:000681210.1SLC30A2, SLC30A4
3cellular response to zinc ion starvationGO:003422410.0SLC39A4, SLC39A5
4cellular zinc ion homeostasisGO:000688210.0SLC39A4, SLC39A5
5metal ion transportGO:003000110.0SLC39A4, SLC39A5
6zinc II ion transmembrane importGO:00715789.7SLC39A4, SLC39A5
7zinc II ion transmembrane transportGO:00715779.7SLC30A2, SLC30A4
8response to zinc ionGO:00100439.6OTC, SLC30A2, SLC30A4
9ion transportGO:00068118.9SLC30A2, SLC30A4, SLC39A4, SLC39A5
10transmembrane transportGO:00550858.9SLC30A2, SLC30A4, SLC39A4, SLC39A5
11transportGO:00068108.2ALB, SLC30A2, SLC30A4, SLC39A4, SLC39A5
12zinc II ion transportGO:00068298.1SLC30A2, SLC30A4, SLC39A4, SLC39A5

Molecular functions related to Enteropathica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cation transmembrane transporter activityGO:00083249.8SLC30A2, SLC30A4
2metal ion transmembrane transporter activityGO:00468739.6SLC39A4, SLC39A5
3zinc ion transmembrane transporter activityGO:00053858.1SLC30A2, SLC30A4, SLC39A4, SLC39A5

Sources for Enteropathica

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet