Enteropathy-Associated T-Cell Lymphoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Enteropathy-Associated T-Cell Lymphoma

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³²MalaCards
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MalaCards: Enteropathy-Associated T-Cell Lymphoma, also known as high-grade pleomorphic peripheral t-cell lymphoma, is related to celiac disease and colon lymphoma. An important gene associated with Enteropathy-Associated T-Cell Lymphoma is CD3G (CD3g molecule, gamma (CD3-TCR complex)), and among its related pathways are Akt Signaling and Allograft rejection. The compound prednisolone have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Enteropathy-Associated T-Cell Lymphoma

Sources:
⁴²NIH Rare Diseases, ⁴⁸Orphanet, ⁶⁰UMLS, ³⁵MESH via Orphanet, ²⁶ICD10 via Orphanet, ⁵⁷SNOMED-CT via Orphanet, ⁶¹UMLS via Orphanet, ²⁵ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases, Blood diseases, Immune diseases

ICD10: ²⁶ ²⁵

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Mature T/NK-cell lymphomas

Peripheral T-cell lymphoma, not classified

Other specified types of T/NK-cell lymphoma

Enteropathy-type (intestinal) T-cell lymphoma

Characteristics (Orphanet epidemiological data):

⁴⁸

enteropathy-associated t-cell lymphoma:
Age of onset: Adulthood

Aliases & Descriptions:

enteropathy-associated t-cell lymphoma ⁴² ⁴⁸ ⁶⁰

high-grade pleomorphic peripheral t-cell lymphoma ⁴²

enteropathy-type t-cell lymphoma ⁴⁸

intestinal t-cell lymphoma ⁴⁸

eatcl ⁴²

ettl ⁴⁸

eatl ⁴⁸

External Ids:

MESH via Orphanet³⁵ D058527

ICD10 via Orphanet²⁶ C84.4

SNOMED-CT via Orphanet⁵⁷ 103686008, 277654008

UMLS via Orphanet⁶¹ C0456889

ICD10²⁵ C86.2

Related Diseases for Enteropathy-Associated T-Cell Lymphoma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
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Diseases related to Enteropathy-Associated T-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 32)

id	Related Disease	Score	Top Affiliating Genes
1	celiac disease	10.9
2	colon lymphoma	10.5
3	malignant histiocytosis	10.4
4	histiocytosis	10.4
5	composite lymphoma	10.4
6	non-hodgkin lymphoma	10.3
7	hemophagocytic lymphohistiocytosis	10.3
8	obstructive jaundice	10.3
9	gastrointestinal lymphoma	10.3
10	autoimmune hemolytic anemia	10.3
11	sclerosing cholangitis	10.3
12	small intestine lymphoma	10.3
13	cholangitis	10.3
14	colonic disease	10.3
15	eosinophilia	10.3
16	hemolytic anemia	10.3
17	intestinal disease	10.3
18	intestinal perforation	10.3
19	leukocyte disease	10.3
20	myocardial infarction	10.3
21	restrictive cardiomyopathy	10.3
22	stomach disease	10.3
23	cauda equina syndrome	10.3
24	marginal zone b-cell lymphoma	10.3
25	anaplastic large cell lymphoma	10.2
26	lymphangioma	10.2
27	hypereosinophilic syndrome	10.0	CCL11
28	rheumatoid arthritis	10.0	CCL11
29	hepatitis	10.0	CCL11
30	dermatitis	10.0	CCL11
31	hodgkin's lymphoma	10.0	TIA1, CCL11
32	ipex syndrome	10.0	CCL11, CD3G

Graphical network of the top 20 diseases related to Enteropathy-Associated T-Cell Lymphoma:

Clinical Features for Enteropathy-Associated T-Cell Lymphoma

Drugs & Therapeutics for Enteropathy-Associated T-Cell Lymphoma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Enteropathy-Associated T-Cell Lymphoma

Drug clinical trials:

Search ClinicalTrials for Enteropathy-Associated T-Cell Lymphoma

Search NIH Clinical Center for Enteropathy-Associated T-Cell Lymphoma

Search CenterWatch for Enteropathy-Associated T-Cell Lymphoma

Genetic Tests for Enteropathy-Associated T-Cell Lymphoma

Anatomical Context for Enteropathy-Associated T-Cell Lymphoma

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³²MalaCards
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MalaCards organs/tissues related to Enteropathy-Associated T-Cell Lymphoma:

³²

T cells

Animal Models for Enteropathy-Associated T-Cell Lymphoma or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Enteropathy-Associated T-Cell Lymphoma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	8.5	CD3G, CCL11, TIA1
2	hematopoietic system phenotype	MP:0005397	8.2	CD3G, CCL11, TIA1

Publications for Enteropathy-Associated T-Cell Lymphoma

Genes related to Enteropathy-Associated T-Cell Lymphoma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Enteropathy-Associated T-Cell Lymphoma:

id	Symbol	Description	Score	Implication
1	CD3G	CD3g molecule, gamma (CD3-TCR complex)	23.59	GeneCards inferred : Publications, Disorders (show sections)
2	CCL11	chemokine (C-C motif) ligand 11	16.92	GeneCards inferred : Publications, Disorders (show sections)
3	TIA1	TIA1 cytotoxic granule-associated RNA binding protein	10.26	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Enteropathy-Associated T-Cell Lymphoma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	3	3	3
2	LSBio	-	-	3

Genetic Variations for Enteropathy-Associated T-Cell Lymphoma

Expression for genes affiliated with Enteropathy-Associated T-Cell Lymphoma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Enteropathy-Associated T-Cell Lymphoma

Search GEO for disease gene expression data for Enteropathy-Associated T-Cell Lymphoma.

Pathways for genes affiliated with Enteropathy-Associated T-Cell Lymphoma

Sources:
⁵¹QIAGEN, ²⁹KEGG
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Pathways related to Enteropathy-Associated T-Cell Lymphoma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Akt Signaling⁵¹ Hide members p38 Signaling⁵¹ Tec Kinases Signaling⁵¹	9.0	CD3G, CCL11
2	Allograft rejection²⁹ Hide members CTL Mediated Apoptosis⁵¹ Asthma²⁹	9.0	CD3G, CCL11