Enteropathy-Associated T-Cell Lymphoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Enteropathy-Associated T-Cell Lymphoma

MalaCards based summary: Enteropathy-Associated T-Cell Lymphoma, also known as high-grade pleomorphic peripheral t-cell lymphoma, is related to celiac disease and refractory celiac disease. An important gene associated with Enteropathy-Associated T-Cell Lymphoma is CD3G (CD3g molecule, gamma (CD3-TCR complex)), and among its related pathways are ERK Signaling and PEDF Induced Signaling. The compounds threonine and prednisolone have been mentioned in the context of this disorder. Affiliated tissues include t cells, colon and lymph node, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Enteropathy-Associated T-Cell Lymphoma

Sources:
⁴²NIH Rare Diseases, ⁴⁸Orphanet, ⁶¹UMLS, ³⁵MESH via Orphanet, ²⁷ICD10 via Orphanet, ⁶²UMLS via Orphanet, ²⁶ICD10
See all sources

Enteropathy-Associated T-Cell Lymphoma, Aliases & Descriptions:

Name: Enteropathy-Associated T-Cell Lymphoma ⁴² ⁴⁸ ⁶¹

High-Grade Pleomorphic Peripheral T-Cell Lymphoma ⁴²

Enteropathy-Type T-Cell Lymphoma ⁴⁸

Intestinal T-Cell Lymphoma ⁴⁸

Eatcl ⁴²

Ettl ⁴⁸

Eatl ⁴⁸

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Gastrointestinal diseases, Blood diseases, Immune diseases

ICD10: ²⁷ ²⁶

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Mature T/NK-cell lymphomas

Peripheral T-cell lymphoma, not classified

Other specified types of T/NK-cell lymphoma

Enteropathy-type (intestinal) T-cell lymphoma

Orphanet: ⁴⁸

Rare gastroenterological diseases

Rare haematological diseases

Rare tumors

Characteristics (Orphanet epidemiological data):

⁴⁸

enteropathy-associated t-cell lymphoma:
Age of onset: Adulthood

External Ids:

MESH via Orphanet³⁵ D058527

ICD10 via Orphanet²⁷ C84.4

UMLS via Orphanet⁶² C0456889

ICD10²⁶ C86.2

Related Diseases for Enteropathy-Associated T-Cell Lymphoma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Enteropathy-Associated T-Cell Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 31)

id	Related Disease	Score	Top Affiliating Genes
1	celiac disease	10.9
2	refractory celiac disease	10.7
3	malignant histiocytosis	10.5
4	histiocytosis	10.5
5	non-hodgkin lymphoma	10.4
6	marginal zone b-cell lymphoma	10.3
7	cauda equina syndrome	10.3
8	b-cell lymphomas	10.3
9	hemolytic anemia	10.3
10	hemophagocytic lymphohistiocytosis	10.3
11	myocardial infarction	10.3
12	peripheral t-cell lymphoma	10.3
13	sclerosing cholangitis	10.3
14	autoimmune hemolytic anemia	10.3
15	obstructive jaundice	10.3
16	jejunoileitis	10.3
17	cholangitis	10.3
18	eosinophilia	10.3
19	intestinal perforation	10.3
20	restrictive cardiomyopathy	10.3
21	autoimmune enteropathy	10.3
22	primary sclerosing cholangitis	10.3
23	anaplastic large cell lymphoma	10.2
24	lymphangioma	10.2
25	cavernous lymphangioma	10.2
26	hypereosinophilic syndrome	10.2
27	hodgkin's lymphoma	9.9	TIA1, CCL11
28	leukemia	9.9	TIA1, CCL11
29	ipex syndrome	9.8	CD3G, CCL11
30	burkitt's lymphoma	9.8	TIA1, CCL11
31	melanoma	9.8	CCL11, TIA1

Graphical network of the top 20 diseases related to Enteropathy-Associated T-Cell Lymphoma:

Symptoms for Enteropathy-Associated T-Cell Lymphoma

Drugs & Therapeutics for Enteropathy-Associated T-Cell Lymphoma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Enteropathy-Associated T-Cell Lymphoma

Search NIH Clinical Center for Enteropathy-Associated T-Cell Lymphoma

Genetic Tests for Enteropathy-Associated T-Cell Lymphoma

Anatomical Context for Enteropathy-Associated T-Cell Lymphoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Enteropathy-Associated T-Cell Lymphoma:

³²

T cells, Colon, Lymph node, Brain, Small intestine, Nk cells, B cells

Animal Models for Enteropathy-Associated T-Cell Lymphoma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Enteropathy-Associated T-Cell Lymphoma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	8.5	CD3G, CCL11, TIA1
2	hematopoietic system phenotype	MP:0005397	8.2	CD3G, CCL11, TIA1

Publications for Enteropathy-Associated T-Cell Lymphoma

Sources:
⁵¹PubMed
See all sources

Articles related to Enteropathy-Associated T-Cell Lymphoma:

(show top 50) (show all 102)

id	Title	Authors	Year
1	An unusual case of enteropathy-associated T-cell lymphoma with CD20 positivity. (25308040)	Misra D.S.... Malhotra V.	2014
2	Enteropathy-associated T-cell lymphoma diagnosed and followed-up by using double-balloon enteroscopy. (23541443)	Fukushima M.... Inokuma T.	2013
3	Classic versus type II enteropathy-associated T-cell lymphoma: diagnostic considerations. (23991736)	Arps D.P.... Smith L.B.	2013
4	Enteropathy associated T cell lymphoma in celiac disease: a large retrospective study. (23313469)	Malamut G.... Cellier C.	2013
5	Autologous stem cell transplantation for enteropathy-associated T-cell lymphoma: a retrospective study by the EBMT. (23361910)	Jantunen E.... Dreger P.	2013
6	Brentuximab in the treatment of CD30-positive enteropathy-associated T-cell lymphoma. (23411380)	Khalaf W.F.... Reddy N.	2013
7	Obscure gastrointestinal bleeding and video capsule retention due to enteropathy-associated T-cell lymphoma. (24719605)	Ho H.C.... Hass D.J.	2013
8	Challenges in the diagnosis of enteropathy-associated T cell lymphoma. (23964351)	D'Souza P.M.... Teshima C.W.	2013
9	Type II enteropathy-associated T-cell lymphoma: a multicenter analysis from the Asia Lymphoma Study Group. (22641357)	Tse E.... Kwong Y.L.	2012
10	High frequency of fatal haemophagocytic lymphohistiocytosis syndrome in enteropathy-associated T cell lymphoma. (22100722)	Amiot A.... Bouhnik Y.	2012
11	How I treat enteropathy-associated T-cell lymphoma. (22271451)	Di Sabatino A.... Corazza G.R.	2012
12	Enteropathy-associated T-cell lymphoma, lacking MHC class II, with immune-privileged site recurrence, presenting as bilateral ocular vitreous humour involvement - a case report. (22963578)	Mudhar H.S.... Evans L.S.	2012
13	Second line chemotherapy in patients with enteropathy-associated T cell lymphoma: a retrospective single center analysis. (21520002)	Raderer M.... Chott A.	2012
14	An unusual enteropathy-associated T-cell lymphoma with MYC translocation arising in a Japanese patient: a case report. (22654438)	Okumura K.... Higashi H.	2012
15	Supratentorial metastatic enteropathy-associated T-cell lymphoma: A case report and literature review. (23230525)	Defillo A.... Nussbaum E.S.	2012
16	Early radiological findings on CT in a patient with enteropathy-associated T cell lymphoma. (22670007)	Sato K.... Uchiyama M.	2011
17	Enteropathy-associated T-cell lymphoma: epidemiology, clinical features, and current treatment strategies. (21912848)	Sieniawski M.K.... Lennard A.L.	2011
18	Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent I^I' T-cell receptor expression. (21921780)	Chan J.K.... Chan W.K.	2011
19	A case of enteropathy-associated T-cell lymphoma: diagnosis by flow cytometric immunophenotyping and genome analysis using ascitic fluid. (21604213)	Nishimura M.... Tomo K.	2011
20	Pathological and immunohistological findings and genetic aberrations of intestinal enteropathy-associated T cell lymphoma in Japan. (21323966)	Takeshita M.... Iwashita A.	2011
21	Enteropathy-associated T-cell lymphoma: clinical and histological findings from the international peripheral T-cell lymphoma project. (21566094)	Delabie J.... Weisenburger D.D.	2011
22	Phenotypic and genomic analysis of an exceptional case of enteropathy associated T-cell lymphoma. (20226524)	Tack G.J.... Schreurs M.W.	2010
23	Enteropathy-associated T-cell lymphoma: a review on clinical presentation, diagnosis, therapeutic strategies and perspectives. (21050687)	Chandesris M.O.... Hermine O.	2010
24	Enteropathy associated T-cell lymphoma resulting in restrictive cardiomyopathy and mimicking myocardial infarction. (22767479)	Prichard D.... Mahmud N.	2010
25	Enteropathy associated T-cell lymphoma and its precursor lesions. (20206108)	van de Water J.M.... Mulder C.J.	2010
26	Enteropathy-associated T-cell lymphoma--a clinicopathologic and array comparative genomic hybridization study. (20399483)	Ko Y.H.... Seto M.	2010
27	Enteropathy-associated T cell lymphoma of the jejunum associated with colonic lymphocytosis with aberrant phenotype. (20671042)	Valli R.... Sabattini E.	2010
28	Enteropathy associated T cell lymphoma: common in coeliac disease. (21686880)	Colleran G.C.... Barry K.	2009
29	Management of Enteropathy-Associated T-Cell Lymphoma: An Algorithmic Approach. (20740143)	Babel N.... Chamberlain R.S.	2009
30	Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac disease. (17934841)	Silano M.... Vincenzi M.D.	2008
31	Survival in refractory coeliac disease and enteropathy-associated T-cell lymphoma: retrospective evaluation of single-centre experience. (17470479)	Al-Toma A.... Mulder C.J.	2007
32	Indigo carmine chromoendoscopic appearances of enteropathy-associated T-cell lymphoma during double-balloon endoscopy in a patient with celiac disease. (17614075)	Hadithi M.... Mulder C.J.	2007
33	Abdominal computed tomography in refractory coeliac disease and enteropathy associated T-cell lymphoma. (17461472)	Mallant M.... van Waesberghe J.H.	2007
34	Disappointing outcome of autologous stem cell transplantation for enteropathy-associated T-cell lymphoma. (17531561)	Al-Toma A.... Huijgens P.C.	2007
35	Successful treatment of enteropathy-associated T cell lymphoma with autologous stem cell transplant. (16865575)	Rongey C.... Murray J.	2006
36	Lymphomatous infiltration of the peripheral nervous system in enteropathy-associated T-cell lymphoma. (15804227)	Yap Y.S.... Norman J.	2005
37	Enteropathy-associated T-cell lymphoma with initial manifestation in the CNS. (12771280)	Gobbi C.... Dirnhofer S.	2003
38	High-dose therapy supported by autologous stem cell transplantation in patients with enteropathy-associated T-cell lymphoma. (14959866)	Jantunen E.... Nousiainen T.	2003
39	Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. (10963198)	Cellier C.... Brousse N.	2000
40	Refractory coeliac disease: a window between coeliac disease and enteropathy associated T cell lymphoma. (11232488)	Mulder C.J.... Meijer J.W.	2000
41	Enteropathy-associated T-cell lymphoma and its immunocarcinogenic correlates: case report and review of the literature. (9754448)	Palacio A.... Patarca R.	1998
42	Enteropathy-associated T-cell lymphomas have a cytotoxic T-cell phenotype. (9363445)	de Bruin P.C.... Meijer C.J.	1997
43	Enteropathy-associated T-cell lymphoma: a case report with radiographic and computed tomography appearance. (9179268)	Loberant N.... Szvalb S.	1997
44	Molecular analysis of T-cell clonality in ulcerative jejunitis and enteropathy-associated T-cell lymphoma. (9250161)	Ashton-Key M.... Isaacson P.G.	1997
45	HLA antigen expression in enteropathy associated T cell lymphoma. (8813950)	Ashton-Key M.... Smith M.E.	1996
46	Demonstration of the oligoclonality of an enteropathy associated T-cell lymphoma by monoclonal antibodies and PCR analysis of the T-cell receptor V-beta repertoire on fixed tissue. (8621191)	O'Shea U.D.... Boylston A.W.	1996
47	Pleural lymphoma in a patient presenting with malabsorption: an illustration of the clinicopathological behaviour in a case of enteropathy associated T cell lymphoma. (8244122)	Doyel G.J.... Kesteven P.J.	1993
48	Epstein-Barr virus (EBV) in enteropathy-associated T-cell lymphoma (EATL). (8393922)	Pan L.... Isaacson P.G.	1993
49	Low-grade intestinal lymphoma of intraepithelial T lymphocytes with concomitant enteropathy-associated T cell lymphoma: case report suggesting a possible histogenetic relationship. (2789173)	Alfsen G.C.... Marton P.F.	1989
50	Enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML-1) that defines a membrane molecule on human mucosal lymphocytes. (3260750)	Spencer J.... Isaacson P.G.	1988

Genes related to Enteropathy-Associated T-Cell Lymphoma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Enteropathy-Associated T-Cell Lymphoma:

- Elite gene

id	Symbol	Description	Score	Implication
1	CD3G	CD3g molecule, gamma (CD3-TCR complex)	23.61	GeneCards inferred via : Publications (show sections)
2	CCL11	chemokine (C-C motif) ligand 11	16.94	GeneCards inferred via : Publications (show sections)
3	TIA1	TIA1 cytotoxic granule-associated RNA binding protein	10.27	GeneCards inferred via : Publications (show sections)

Products for genes related to Enteropathy-Associated T-Cell Lymphoma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	2	-	2	2
2	Novus Biologicals	3	3	3	-

Variations for Enteropathy-Associated T-Cell Lymphoma

Expression for genes affiliated with Enteropathy-Associated T-Cell Lymphoma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Enteropathy-Associated T-Cell Lymphoma

Search GEO for disease gene expression data for Enteropathy-Associated T-Cell Lymphoma.

Pathways for genes affiliated with Enteropathy-Associated T-Cell Lymphoma

Sources:
⁴⁹PathCards, ⁵²QIAGEN, ³⁰KEGG, ³⁷NCBI BioSystems Database
See all sources

Pathways related to Enteropathy-Associated T-Cell Lymphoma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	9.0	CD3G, CCL11
2	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	9.0	CD3G, CCL11
3	Akt Signaling⁵² Show member pathways p38 Signaling⁵² Tec Kinases Signaling⁵²	9.0	CD3G, CCL11
4	Allograft rejection³⁰ Show member pathways Autoimmune thyroid disease³⁰ Viral myocarditis³⁰ Intestinal immune network for IgA production³⁰ Allograft Rejection³⁷ Asthma³⁰ Type I diabetes mellitus³⁰ Graft-versus-host disease³⁰ CTL Mediated Apoptosis⁵² Antigen processing and presentation³⁰ THC Differentiation Pathway⁵²	9.0	CD3G, CCL11