ERA
MCID: ENT015
MIFTS: 45

Enthesitis-Related Arthritis (ERA) malady

Eye diseases, Respiratory diseases, Bone diseases, Rare diseases categories

Summaries for Enthesitis-Related Arthritis

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34MalaCards
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MalaCards: Enthesitis-Related Arthritis, also known as juvenile spondylarthropathy, is related to arthritis and psoriatic arthritis, and has symptoms including tendon rupture/tendinitis/bursitis/tenosynovitis, enthesis anomaly/inflammation/enthesitis/enthesopathy and cartilage destruction/chondrolysis. An important gene associated with Enthesitis-Related Arthritis is TLR2 (toll-like receptor 2), and among its related pathways are TRAF Pathway and IL-17 Family Signaling Pathways. The compounds arabinogalactan and diaminopimelic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, eye and t cells, and related mouse phenotypes are hematopoietic system and digestive/alimentary.

Aliases & Classifications for Enthesitis-Related Arthritis

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50Orphanet, 27ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases, Respiratory diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

50
enthesitis-related arthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

enthesitis-related arthritis 50
juvenile spondylarthropathy 50
era 50


External Ids:

ICD10 via Orphanet27 M08.1

Related Diseases for Enthesitis-Related Arthritis

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Enthesitis-Related Arthritis:



Diseases related to enthesitis-related arthritis

Symptoms for Enthesitis-Related Arthritis

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50Orphanet
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Symptoms:

50 (show all 8)
  • tendon rupture/tendinitis/bursitis/tenosynovitis
  • enthesis anomaly/inflammation/enthesitis/enthesopathy
  • cartilage destruction/chondrolysis
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • arthritis/synovitis/synovial proliferation
  • hydrarthrosis/articular/joint effusion
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis

Drugs & Therapeutics for Enthesitis-Related Arthritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Enthesitis-Related Arthritis

Drug clinical trials:

Search ClinicalTrials for Enthesitis-Related Arthritis

Search NIH Clinical Center for Enthesitis-Related Arthritis

Search CenterWatch for Enthesitis-Related Arthritis

Genetic Tests for Enthesitis-Related Arthritis

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Anatomical Context for Enthesitis-Related Arthritis

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34MalaCards
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MalaCards organs/tissues related to Enthesitis-Related Arthritis:

34
Bone, Eye, T cells, Monocytes

Animal Models for Enthesitis-Related Arthritis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Enthesitis-Related Arthritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5IL17C, TLR4, TLR2
2MP:00053818.4IL17C, TLR4, TLR2
3MP:00107718.2IL17C, TLR4, TLR2

Publications for Enthesitis-Related Arthritis

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53PubMed
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Articles related to Enthesitis-Related Arthritis:

(show all 36)
idTitleAuthorsYear
1
Inflammatory changes of the lumbar spine in children and adolescents with enthesitis-related arthritis: magnetic resonance imaging findings. (24127385)
2014
2
TLR4 endogenous ligand MRP8/14 level in enthesitis-related arthritis and its association with disease activity and TLR4 expression. (24231443)
2014
3
Lack of association of single nucleotide polymorphisms in toll-like receptors 2 and 4 with enthesitis-related arthritis category of juvenile idiopathic arthritis in Indian population. (22453525)
2013
4
Evaluation and Treatment of Enthesitis-Related Arthritis. (24403667)
2013
5
Detection of enthesitis in children with Enthesitis-related arthritis: Dolorimeter examination compared to ultrasonography. (24114526)
2013
6
Efficacy and safety of open-label etanercept on extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1 (week 12) of the CLIPPER study. (23696632)
2013
7
Synovial fluid mononuclear cell gene expression profiling suggests dysregulation of innate immune genes in enthesitis-related arthritis patients. (22763987)
2012
8
Utility of magnetic resonance imaging when following up sacroiliitis in enthesitis-related arthritis. (22310966)
2012
9
Membrane-bound toll-like receptors are overexpressed in peripheral blood and synovial fluid mononuclear cells of enthesitis-related arthritis category of juvenile idiopathic arthritis (JIAa89ERA) patients and lead to secretion of inflammatory mediators. (22302567)
2012
10
A modified juvenile arthritis damage index to improve articular damage assessment in juvenile idiopathic arthritis--enthesitis-related arthritis (JIA-ERA). (22234493)
2012
11
Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry. (23070991)
2012
12
IL1 gene polymorphisms in enthesitis related arthritis category of juvenile idiopathic arthritis (ERA-JIA). (22124790)
2012
13
Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis. (21281511)
2011
14
Tumor necrosis factor-blocking agents for children with enthesitis-related arthritis--data from the dutch arthritis and biologicals in children register, 1999-2010. (21844151)
2011
15
Attainment of inactive disease status following initiation of TNF-I+ inhibitor therapy for juvenile idiopathic arthritis: enthesitis-related arthritis predicts persistent active disease. (22089470)
2011
16
Expression of Toll-like receptors 2 and 4 is increased in peripheral blood and synovial fluid monocytes of patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis. (21097451)
2011
17
Evidence of cellular immune response to outer membrane protein of Salmonella typhimurium in patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis. (21041273)
2011
18
Levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis. (21885500)
2011
19
A child with x-linked agammaglobulinemia and enthesitis-related arthritis. (21760802)
2011
20
Fecal calprotectin in children with the enthesitis-related arthritis subtype of juvenile idiopathic arthritis. (21965700)
2011
21
Enthesitis in an inception cohort of enthesitis-related arthritis. (21618453)
2011
22
Evaluation of MR imaging guided steroid injection of the sacroiliac joints for the treatment of children with refractory enthesitis-related arthritis. (21046404)
2011
23
Nutritional supplementation and dietary restriction in the resolution of enthesitis-related arthritis. (21541080)
2011
24
Early predictors of juvenile sacroiliitis in enthesitis-related arthritis. (20810515)
2010
25
Proteomic analysis of plasma to reveal the impact of short-term etanercept therapy in pediatric patients with enthesitis-related arthritis: a case report. (20402637)
2010
26
Synovial fluid RANKL and matrix metalloproteinase levels in enthesitis related arthritis subtype of juvenile idiopathic arthritis. (19052752)
2009
27
Fistulizing anorectal Crohn disease in a child with severe HLA-B27-associated enthesitis-related arthritis. (19322059)
2009
28
Th1 and Th17 Predominance in the Enthesitis-related Arthritis Form of Juvenile Idiopathic Arthritis. (19531753)
2009
29
Enthesitis-related arthritis in Kikuchi-Fujimoto disease. (18470474)
2008
30
Chemokine and chemokine receptor analysis reveals elevated interferon-inducible protein-10 (IP)-10/CXCL10 levels and increased number of CCR5+ and CXCR3+ CD4 T cells in synovial fluid of patients with enthesitis-related arthritis (ERA). (17374135)
2007
31
Is the enthesitis-related arthritis subtype of juvenile idiopathic arthritis a form of chronic reactive arthritis? (16522678)
2006
32
Successful treatment with methotrexate of a child with atlantoaxial subluxation from enthesitis-related arthritis. (16762165)
2006
33
Long-term outcome and prognostic factors in enthesitis-related arthritis: a case-control study. (17075863)
2006
34
Radiologic Improvement of juvenile idiopathic arthritis-enthesitis-related arthritis following anti-tumor necrosis factor-alpha blockade with etanercept. (16755667)
2006
35
Elevated concentrations of monocyte derived cytokines in synovial fluid of children with enthesitis related arthritis and polyarticular types of juvenile idiopathic arthritis. (15996076)
2005
36
Prolonged efficacy of etanercept in refractory enthesitis-related arthritis. (15468375)
2004

Variations for Enthesitis-Related Arthritis

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Expression for genes affiliated with Enthesitis-Related Arthritis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Enthesitis-Related Arthritis

Search GEO for disease gene expression data for Enthesitis-Related Arthritis.

Pathways for genes affiliated with Enthesitis-Related Arthritis

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Sources:
51PathCards, 54QIAGEN, 55R&D Systems, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 58SinoBiological, 62Tocris Bioscience, 5Cell Signaling Technology
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Pathways related to Enthesitis-Related Arthritis according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9TLR2
2
Show member pathways
9.3IL17C, TLR2
3
Show member pathways
9.0TLR4, TLR2
49.0TLR4, TLR2
5
Show member pathways
9.0TLR2, TLR4
69.0TLR2, TLR4
7
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.0TLR2, TLR4
89.0TLR4, TLR2
9
Show member pathways
9.0TLR4, TLR2
109.0TLR4, TLR2
11
Show member pathways
9.0TLR4, TLR2
12
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.0TLR2, TLR4
139.0TLR4, TLR2
14
Show member pathways
9.0TLR4, TLR2
159.0TLR2, TLR4
16
Show member pathways
9.0TLR4, TLR2
17
Show member pathways
IL27-mediated signaling events39
9.0TLR2, TLR4
189.0TLR2, TLR4
199.0TLR4, TLR2
209.0TLR2, TLR4
21
Show member pathways
9.0TLR4, TLR2
22
Show member pathways
9.0TLR4, TLR2
239.0TLR4, TLR2
249.0TLR2, TLR4
25
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.0TLR4, TLR2
269.0TLR4, TLR2

Compounds for genes affiliated with Enthesitis-Related Arthritis

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 25HMDB, 52PharmGKB
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Compounds related to Enthesitis-Related Arthritis according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1arabinogalactan469.5TLR4, TLR2
2diaminopimelic acid469.5TLR4, TLR2
3pam2csk4629.5TLR2, TLR4
4pam3csk4629.5TLR2, TLR4
5poly(i:c)629.5TLR2, TLR4
6loxoribine46 3010.4TLR2, TLR4
7glucuronoxylomannan469.4TLR4, TLR2
8resiquimod46 6210.4TLR2, TLR4
9muramyl dipeptide46 3010.4TLR4, TLR2
10hbd2469.4TLR4, TLR2
11lauric acid46 3010.4TLR2, TLR4
12flagellin46 3010.4TLR4, TLR2
13zymosan469.4TLR4, TLR2
14imiquimod46 62 30 1212.4TLR2, TLR4
15mannan469.4TLR4, TLR2
16docosahexaenoic acid46 30 2511.4TLR4, TLR2
17polymyxin b469.4TLR2, TLR4
18lipoteichoic acid469.4TLR4, TLR2
19polyinosinic-polycytidylic acid469.4TLR4, TLR2
20poly(i-c)469.4TLR2, TLR4
21il 10469.4TLR4, TLR2
22glycolipid469.4TLR2, TLR4
23anti-fungal469.4TLR4, TLR2
24peptidoglycan46 3010.4TLR4, TLR2
25ccl346 3010.4TLR2, TLR4
26latex469.3TLR4, TLR2
27palmitate469.3TLR2, TLR4
28agarose469.3TLR4, TLR2
29simvastatin46 52 62 30 25 1214.3TLR4, TLR2
30mannose469.3TLR2, TLR4
31endotoxin469.3TLR4, TLR2
32tacrolimus46 52 1211.3TLR2, TLR4
33calcitriol46 62 25 1212.3TLR4, TLR2
34rantes469.2TLR4, TLR2
35sb 20358046 6210.2TLR2, TLR4
36polysaccharide469.2TLR4, TLR2
37vitamin d469.1TLR2, TLR4
38fibrinogen469.1TLR4, TLR2
39phospholipid469.0TLR4, TLR2
40actinomycin d469.0TLR4, TLR2
41histamine46 30 2510.9TLR2, TLR4
42wortmannin468.7TLR4, TLR2

GO Terms for genes affiliated with Enthesitis-Related Arthritis

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17Gene Ontology
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Cellular components related to Enthesitis-Related Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0TLR4, TLR2

Biological processes related to Enthesitis-Related Arthritis according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of macrophage cytokine productionGO:0609079.4TLR4, TLR2
2cellular response to lipoteichoic acidGO:0712239.4TLR4, TLR2
3negative regulation of interleukin-17 productionGO:0327009.4TLR4, TLR2
4positive regulation of tumor necrosis factor biosynthetic processGO:0425359.4TLR2, TLR4
5I-kappaB phosphorylationGO:0072529.4TLR4, TLR2
6positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.4TLR4, TLR2
7positive regulation of chemokine productionGO:0327229.4TLR2, TLR4
8positive regulation of interleukin-10 productionGO:0327339.4TLR4, TLR2
9positive regulation of NF-kappaB import into nucleusGO:0423469.4TLR4, TLR2
10positive regulation of interleukin-8 productionGO:0327579.3TLR4, TLR2
11positive regulation of interferon-beta productionGO:0327289.3TLR2, TLR4
12positive regulation of interleukin-12 productionGO:0327359.3TLR4, TLR2
13lipopolysaccharide-mediated signaling pathwayGO:0316639.3TLR4, TLR2
14positive regulation of nitric oxide biosynthetic processGO:0454299.3TLR2, TLR4
15positive regulation of tumor necrosis factor productionGO:0327609.3TLR4, TLR2
16positive regulation of interleukin-6 productionGO:0327559.3TLR4, TLR2
17positive regulation of inflammatory responseGO:0507299.3TLR2, TLR4
18toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.2TLR4, TLR2
19toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.2TLR4, TLR2
20toll-like receptor 2 signaling pathwayGO:0341349.2TLR2, TLR4
21MyD88-dependent toll-like receptor signaling pathwayGO:0027559.1TLR4, TLR2
22toll-like receptor 4 signaling pathwayGO:0341429.1TLR4, TLR2
23toll-like receptor signaling pathwayGO:0022249.0TLR2, TLR4
24immune responseGO:0069559.0TLR4, TLR2
25inflammatory responseGO:0069549.0IL17C, TLR2
26positive regulation of NF-kappaB transcription factor activityGO:0510928.9TLR4, TLR2

Molecular functions related to Enthesitis-Related Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048729.0TLR4, TLR2
2lipopolysaccharide receptor activityGO:0018758.9TLR4, TLR2
3transmembrane signaling receptor activityGO:0048888.7TLR4, TLR2

Products for genes affiliated with Enthesitis-Related Arthritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Enthesitis-Related Arthritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet