ERA
MCID: ENT015
MIFTS: 50

Enthesitis-Related Arthritis (ERA) malady

Eye, Respiratory, Bone categories

Summaries for Enthesitis-Related Arthritis

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33MalaCards
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MalaCards: Enthesitis-Related Arthritis, also known as juvenile spondylarthropathy, is related to arthritis and hepatitis c, and has symptoms including chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis, hydrarthrosis/articular/joint effusion and arthritis/synovitis/synovial proliferation. An important gene associated with Enthesitis-Related Arthritis is ERAP1 (endoplasmic reticulum aminopeptidase 1), and among its related pathways are ATF-2 transcription factor network and TGF-Beta Pathway. The compounds pge2 and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include monocytes and t cells, and related mouse phenotypes are respiratory system and skeleton.

Aliases & Classifications for Enthesitis-Related Arthritis

Sources:
49Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye, Respiratory, Bone


Characteristics (Orphanet epidemiological data):

49
enthesitis-related arthritis:
Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

enthesitis-related arthritis 49
juvenile spondylarthropathy 49
era 49


External Ids:

ICD10 via Orphanet26 M08.1

Related Diseases for Enthesitis-Related Arthritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Enthesitis-Related Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 516)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.5MMP3, IL6, IL8, TNFSF11, TIMP1
2hepatitis c30.5TLR4, TLR2, IFNG
3psoriatic arthritis30.5TLR2, TNFSF11, MMP3, MMP1
4acquired immunodeficiency syndrome30.4IL2, IL6
5tuberculosis30.4TLR4, TLR2, IFNG, IL4, IL2
6acute myocardial infarction30.3TNFSF11
7crohn's disease30.3IL23R
8agammaglobulinemia30.3IL4, IL2
9adenocarcinoma30.2ERAP1, TNFSF11, TIMP1
10abdominal aortic aneurysm30.2MMP1, MMP3, TIMP1
11biliary atresia30.1TIMP1
12duodenal ulcer30.1IL8
13measles30.1TLR2
14cystic fibrosis30.0IL8, TLR4
15bacterial meningitis30.0TLR2, IL8
16vascular disease30.0TIMP1, IL8, IL6, IL2, MMP3
17atherosclerosis30.0TIMP1, TLR4, TLR2, IL8, IL6, MMP3
18colorectal cancer29.9TLR4, TLR2
19ulcerative colitis29.9IFNG, TLR2, TLR4, TNFSF11, IL4, MMP1
20bronchiolitis obliterans29.8IL8
21kaposi's sarcoma29.8IL6
22astrocytoma29.8MMP3, IL6
23bronchiolitis29.8IL8, TLR4
24deficiency anemia29.8IL2, IL6, TIMP1
25graft versus host disease29.8IFNG, IL4, IL2
26invasive aspergillosis29.8TLR2, TLR4
27aspergillosis29.8TLR4, TLR2, IFNG
28sepsis29.8TLR4, TLR2, IL8, IL6
29gastric ulcer29.6TLR2
30viral hepatitis29.6TLR2
31bronchopulmonary dysplasia29.6IL8, TIMP1
32uveitis29.6IL4, IFNG
33atopic dermatitis29.6IL4, TLR2
34tularemia29.6TLR2
35leukopenia29.6IL2, IL6
36coronary heart disease29.6IL6, TLR4
37idiopathic pulmonary fibrosis29.6TIMP1, IFNG, IL8, MMP1
38lepromatous leprosy29.6TLR2, IFNG, IL4, IL2
39septic shock29.6TLR4, TLR2, IL8, IL6
40burkitt's lymphoma29.6TLR4, IL4, IL6, IL2, MMP3
41enthesitis-related juvenile idiopathic arthritis10.8
42lymphoma, diffuse large cell10.5
43cytomegalovirus retinitis10.4
44psoriatic juvenile idiopathic arthritis10.4
45juvenile psoriatic arthritis10.4
46hepatitis a10.3
47progressive multifocal leukoencephalopathy10.3
48follicular lymphoma10.3
49juvenile rheumatoid arthritis10.3
50spondylarthropathy10.3

Graphical network of the top 20 diseases related to Enthesitis-Related Arthritis:



Diseases related to enthesitis-related arthritis

Clinical Features for Enthesitis-Related Arthritis

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 8)
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • hydrarthrosis/articular/joint effusion
  • arthritis/synovitis/synovial proliferation
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • abnormal dentition/dental position/implantation/unerupted/dental ankylosis
  • cartilage destruction/chondrolysis
  • enthesis anomaly/inflammation/enthesitis/enthesopathy
  • tendon rupture/tendinitis/bursitis/tenosynovitis

Drugs & Therapeutics for Enthesitis-Related Arthritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Enthesitis-Related Arthritis

Drug clinical trials:

Search ClinicalTrials for Enthesitis-Related Arthritis

Search NIH Clinical Center for Enthesitis-Related Arthritis

Search CenterWatch for Enthesitis-Related Arthritis

Genetic Tests for Enthesitis-Related Arthritis

Anatomical Context for Enthesitis-Related Arthritis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Enthesitis-Related Arthritis:

33
Monocytes, T cells

Animal Models for Enthesitis-Related Arthritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Enthesitis-Related Arthritis

Sources:
51PubMed
See all sources

Articles related to Enthesitis-Related Arthritis:

(show all 38)
idTitleAuthorsYear
1
Inflammatory changes of the lumbar spine in children and adolescents with enthesitis-related arthritis: magnetic resonance imaging findings. (24127385)
2014
2
TLR4 endogenous ligand MRP8/14 level in enthesitis-related arthritis and its association with disease activity and TLR4 expression. (24231443)
2014
3
Lack of association of single nucleotide polymorphisms in toll-like receptors 2 and 4 with enthesitis-related arthritis category of juvenile idiopathic arthritis in Indian population. (22453525)
2013
4
Evaluation and Treatment of Enthesitis-Related Arthritis. (24403667)
2013
5
Detection of enthesitis in children with Enthesitis-related arthritis: Dolorimeter examination compared to ultrasonography. (24114526)
2013
6
Efficacy and safety of open-label etanercept on extended oligoarticular juvenile idiopathic arthritis, enthesitis-related arthritis and psoriatic arthritis: part 1 (week 12) of the CLIPPER study. (23696632)
2013
7
Synovial fluid mononuclear cell gene expression profiling suggests dysregulation of innate immune genes in enthesitis-related arthritis patients. (22763987)
2012
8
Utility of magnetic resonance imaging when following up sacroiliitis in enthesitis-related arthritis. (22310966)
2012
9
Membrane-bound toll-like receptors are overexpressed in peripheral blood and synovial fluid mononuclear cells of enthesitis-related arthritis category of juvenile idiopathic arthritis (JIAa89ERA) patients and lead to secretion of inflammatory mediators. (22302567)
2012
10
A modified juvenile arthritis damage index to improve articular damage assessment in juvenile idiopathic arthritis--enthesitis-related arthritis (JIA-ERA). (22234493)
2012
11
Enthesitis-related arthritis is associated with higher pain intensity and poorer health status in comparison with other categories of juvenile idiopathic arthritis: the Childhood Arthritis and Rheumatology Research Alliance Registry. (23070991)
2012
12
IL1 gene polymorphisms in enthesitis related arthritis category of juvenile idiopathic arthritis (ERA-JIA). (22124790)
2012
13
Diagnosis and treatment of enthesitis-related arthritis. (23236258)
2012
14
Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis. (21281511)
2011
15
Tumor necrosis factor-blocking agents for children with enthesitis-related arthritis--data from the dutch arthritis and biologicals in children register, 1999-2010. (21844151)
2011
16
Attainment of inactive disease status following initiation of TNF-I+ inhibitor therapy for juvenile idiopathic arthritis: enthesitis-related arthritis predicts persistent active disease. (22089470)
2011
17
Expression of Toll-like receptors 2 and 4 is increased in peripheral blood and synovial fluid monocytes of patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis. (21097451)
2011
18
Evidence of cellular immune response to outer membrane protein of Salmonella typhimurium in patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis. (21041273)
2011
19
Levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis. (21885500)
2011
20
A child with x-linked agammaglobulinemia and enthesitis-related arthritis. (21760802)
2011
21
Fecal calprotectin in children with the enthesitis-related arthritis subtype of juvenile idiopathic arthritis. (21965700)
2011
22
Enthesitis in an inception cohort of enthesitis-related arthritis. (21618453)
2011
23
Evaluation of MR imaging guided steroid injection of the sacroiliac joints for the treatment of children with refractory enthesitis-related arthritis. (21046404)
2011
24
Nutritional supplementation and dietary restriction in the resolution of enthesitis-related arthritis. (21541080)
2011
25
Early predictors of juvenile sacroiliitis in enthesitis-related arthritis. (20810515)
2010
26
Proteomic analysis of plasma to reveal the impact of short-term etanercept therapy in pediatric patients with enthesitis-related arthritis: a case report. (20402637)
2010
27
Synovial fluid RANKL and matrix metalloproteinase levels in enthesitis related arthritis subtype of juvenile idiopathic arthritis. (19052752)
2009
28
Fistulizing anorectal Crohn disease in a child with severe HLA-B27-associated enthesitis-related arthritis. (19322059)
2009
29
Th1 and Th17 Predominance in the Enthesitis-related Arthritis Form of Juvenile Idiopathic Arthritis. (19531753)
2009
30
Enthesitis-related arthritis in Kikuchi-Fujimoto disease. (18470474)
2008
31
Outcome in patients with enthesitis related arthritis (ERA): juvenile arthritis damage index (JADI) and functional status. (18945336)
2008
32
Chemokine and chemokine receptor analysis reveals elevated interferon-inducible protein-10 (IP)-10/CXCL10 levels and increased number of CCR5+ and CXCR3+ CD4 T cells in synovial fluid of patients with enthesitis-related arthritis (ERA). (17374135)
2007
33
Is the enthesitis-related arthritis subtype of juvenile idiopathic arthritis a form of chronic reactive arthritis? (16522678)
2006
34
Successful treatment with methotrexate of a child with atlantoaxial subluxation from enthesitis-related arthritis. (16762165)
2006
35
Long-term outcome and prognostic factors in enthesitis-related arthritis: a case-control study. (17075863)
2006
36
Radiologic Improvement of juvenile idiopathic arthritis-enthesitis-related arthritis following anti-tumor necrosis factor-alpha blockade with etanercept. (16755667)
2006
37
Elevated concentrations of monocyte derived cytokines in synovial fluid of children with enthesitis related arthritis and polyarticular types of juvenile idiopathic arthritis. (15996076)
2005
38
Prolonged efficacy of etanercept in refractory enthesitis-related arthritis. (15468375)
2004

Genetic Variations for Enthesitis-Related Arthritis

Expression for genes affiliated with Enthesitis-Related Arthritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Enthesitis-Related Arthritis

Search GEO for disease gene expression data for Enthesitis-Related Arthritis.

Pathways for genes affiliated with Enthesitis-Related Arthritis

Sources:
38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 53R&D Systems, 54Reactome, 30KEGG, 60Tocris Bioscience
See all sources

Pathways related to Enthesitis-Related Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1IL8
2
Hide members
9.8IL2, TIMP1
3
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.8TNFSF11, IFNG
4
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9.7IL6, IL23R
5
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9.6IL23R, TNFSF11, TIMP1
6
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9.6TNFSF11, TIMP1, IL23R
7
Cell adhesion ECM remodeling
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9.6MMP3, TIMP1, MMP1
8
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9.6MMP1, TIMP1, MMP3
99.4TNFSF11, TIMP1, IL6
10
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
9.3TIMP1, IL6, MMP1
119.3IL4, IFNG, IL2
12
Hide members
9.3IFNG, IL2, IL4
139.3IFNG, IL4, IL2
14
Hide members
9.3IFNG, IL4, IL2
159.2MMP1, IL6, IL8
16
Mucin expression in CF via IL-6, IL-17 signaling pathways
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9.1IL17C, TLR2
179.0TLR2, TLR4
18
Hide members
9.0TIMP1, TLR4, IL23R, TNFSF11
198.9IL8, TLR4, IL6
20
Hide members
8.9IFNG, IL2, IL4, IL8
218.8TLR2, TLR4, TNFSF11
22
Hide members
8.7IL23R, TLR2, TLR4
23
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8.7IL2, IL6, TIMP1, MMP1, MMP3
24
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8.7TLR4, TLR2, IL2
25
Cytokine production by Th17 cells in CF (Mouse model)
8.6IL23R, IL6, IL8, TLR4
268.6TLR4, IL4, IL2, IL6
278.6IFNG, TLR2, TLR4
288.6TIMP1, TLR4, IFNG, IL6
29
Development PDGF signaling via STATs and NF-kB
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8.5IL6, TIMP1, IL23R, IL2, IFNG
308.5IL2, IL23R, IFNG, IL4, IL6
31
Hide members
8.5IL6, IL8, IFNG, TLR4
328.5TLR4, IL6, IL8, IFNG
338.4IL6, IL2, MMP1, IFNG, IL8
348.4IL2, IFNG, IL6, IL8, IL4
35
Hide members
8.2IL6, TIMP1, TLR2, TLR4
368.1TLR2, TNFSF11, IL4, IL6, IL8
37
Hide members
8.1IL8, IL6, TLR2, TLR4
388.1TLR4, IL6, IL8, TLR2
398.1MMP1, IL2, IFNG, IL4, IL8, IL6
408.1TLR4, TLR2, IFNG, IL6
41
Hide members
7.9IFNG, TLR2, TLR4, IL4, IL2
427.8IL2, IL4, TLR4, TLR2, IL6
437.8IL4, IL6, TLR4, TLR2, IL8
447.8MMP1, IL6, IFNG, TLR4, TLR2
45
Hide members
7.7IFNG, TLR4, TLR2, IL2, IL6
467.6TLR4, TLR2, IL8, IFNG, IL6
47
Immune response Bacterial infections in normal airways
7.6TLR2, TLR4, IFNG, IL8, IL6
48
Hide members
7.3IL6, IL2, IL8, IFNG, TLR4, TLR2
49
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6.9IL2, IFNG, IL8, IL4, TLR2, TLR4
50
Hide members
6.5TLR2, TIMP1, IL23R, IL2, TLR4, IL8

Compounds for genes affiliated with Enthesitis-Related Arthritis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Enthesitis-Related Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1pge24510.5IL2
2gm-csf45 2911.4IFNG
3pentoxifylline45 1111.2MMP1, IL4
4hydrocortisone45 2 60 1113.1IL8, MMP1
5cycloheximide4510.1TLR2
6cyclosporin a45 29 6011.9IFNG, TNFSF11, MMP1
7prostaglandin459.9MMP1, MMP3, TNFSF11
8prednisolone45 29 1111.8MMP3, MMP1
9lxa4459.5MMP3, IL8, MMP1, IL4
10tepoxalin459.3IL2, IL8, IL6
11u0126459.2IL8, IL6, MMP1, TIMP1
12mip 1alpha459.2IL6, IL8, IL4, TNFSF11
13leflunomide50 45 1111.2MMP1, IL6, TNFSF11, TIMP1, MMP3
14alendronate45 50 1111.0TNFSF11, MMP3, TIMP1, MMP1
15ribavirin45 50 1111.0IL4, IL2, MMP1, IFNG, TIMP1
16zoledronic acid458.9MMP1, IFNG, TNFSF11, IL6, IL2
17okt3458.8IL6, IFNG, IL4, IL2
18triptolide458.8MMP3, IL2, IL6, IL8, IFNG
19taurine chloramine458.8IL2, IL6, IL8, TIMP1, IFNG
20il-12458.8IL2, IL6, IL8, IL4, IFNG
21hcec458.6IL6, IL8, TLR2, MMP3
22neopterin458.6IL2, IL6, IL8, IL4, IFNG
23hbd2458.4IL8, IL6, TLR2, TLR4
24etanercept45 50 1110.4MMP1, MMP3, IL8, IL6, TNFSF11, IFNG
25dexamethasone45 50 29 1111.3TLR4, TIMP1, TNFSF11, TLR2, IL6
26sp 60012545 609.3IL8, IL6, MMP1, TNFSF11, TLR2
27tacrolimus45 50 1110.3IL2, TIMP1, TLR2, IFNG, IL4, TNFSF11
28pdtc458.2IL6, TLR4, IL4, IL8, MMP1, IFNG
29peptidoglycan45 299.1TNFSF11, IL6, IL8, TLR4, TLR2
30herbimycin a45 609.1IFNG, TIMP1, IL4, IL8, IL2, MMP1
31lipoteichoic acid458.1IL6, IL8, TLR2, TLR4
32imiquimod45 29 60 1111.0TLR4, IFNG, IL6, IL8, TLR2
33pd 98,059457.9TNFSF11, MMP3, MMP1, IL8, TLR2, TIMP1
34ccl345 298.9TLR4, TLR2, IL6, IL8, IFNG
35n acetylcysteine457.8MMP3, MMP1, IL8, IL6, IL4, TNFSF11
36infliximab45 50 119.8IFNG, TLR4, TIMP1, TNFSF11, IL4, IL6
37rantes457.8IL2, TLR4, TLR2, IFNG, IL4, IL6
38poly(i-c)457.7TLR2, IFNG, TLR4, IL6, IL8, IL4
39vitamin d457.7TNFSF11, TLR2, MMP3, TIMP1, IL6, TLR4
40polymyxin b457.5IL6, IL8, IL4, TNFSF11, TLR4, TLR2
41simvastatin45 50 60 29 11 2412.4IL8, IL4, IFNG, IL6, TLR4, MMP3
42polyinosinic-polycytidylic acid457.4IL2, IL4, IL8, IL6, IFNG, TLR2
43genistein45 29 60 2 11 2412.4IL2, TIMP1, IFNG, TLR4, TNFSF11, IL6
44il 10457.4TLR2, IL4, IL8, IL6, IL2, IFNG
45actinomycin d457.0IFNG, IL2, TLR2, TLR4, TIMP1, IL4
46cysteine456.9TNFSF11, TIMP1, TLR4, TLR2, MMP3, IL4
47calcitriol45 60 11 249.9TIMP1, TLR4, TLR2, IFNG, TNFSF11, IL4
48histamine45 29 248.8TLR2, IFNG, TIMP1, TLR4, MMP3, IL2
49sb 20358045 607.6MMP3, IL6, IL8, IL4, TNFSF11, IFNG
50vegf456.0TLR2, IL4, TIMP1, TLR4, TNFSF11, IFNG

GO Terms for genes affiliated with Enthesitis-Related Arthritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Enthesitis-Related Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098977.7IL6, IL4, IFNG, TLR2, TLR4
2extracellular spaceGO:0056157.2IL6, IFNG, TNFSF11, IL17C, IL4, IL8
3extracellular regionGO:0055767.0ERAP1, TIMP1, MMP1, MMP3, IL2, IL6

Biological processes related to Enthesitis-Related Arthritis according to GeneCards/GeneDecks:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-17 productionGO:03274010.0IL2, IL23R
2positive regulation of chemokine biosynthetic processGO:0450809.9IFNG, IL4
3positive regulation of immunoglobulin secretionGO:0510249.9IL2, IL6
4positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9IL23R, IL4, IL2
5positive regulation of osteoclast differentiationGO:0456729.9IL23R, IFNG, TNFSF11
6positive regulation of activated T cell proliferationGO:0421049.9IL4, IL2, IL23R
7extracellular matrix disassemblyGO:0226179.9MMP1, MMP3, TIMP1
8neutrophil apoptotic processGO:0017819.8IFNG, IL6
9positive regulation of isotype switching to IgG isotypesGO:0483049.7IL2, IL4, IFNG
10monocyte chemotaxisGO:0025489.7IL6, TNFSF11
11positive regulation of interleukin-12 biosynthetic processGO:0450849.7TLR4, IFNG
12positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.6IL4, IL6, TNFSF11
13positive regulation of interferon-gamma productionGO:0327299.5TLR4, IL2, IL23R
14defense response to protozoanGO:0428329.5IL6, IL4, IFNG
15positive regulation of B cell proliferationGO:0308909.5TLR4, IL4, IL2
16positive regulation of MHC class II biosynthetic processGO:0453489.5IL4, TLR4, IFNG
17defense response to Gram-negative bacteriumGO:0508299.4IL23R, IL6, TLR4
18positive regulation of interleukin-10 productionGO:0327339.4TLR4, IL4
19positive regulation of macrophage cytokine productionGO:0609079.4TLR2, TLR4
20cellular response to lipoteichoic acidGO:0712239.3TLR4, TLR2
21cellular response to lipopolysaccharideGO:0712229.3IL8, IFNG, TLR4
22positive regulation of T cell proliferationGO:0421029.3IFNG, IL4, IL6, IL23R
23negative regulation of growth of symbiont in hostGO:0441309.3IFNG, TLR2
24positive regulation of tumor necrosis factor biosynthetic processGO:0425359.3TLR2, TLR4
25positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.2TLR2, TLR4
26negative regulation of osteoclast differentiationGO:0456719.2IL4, TLR4
27I-kappaB phosphorylationGO:0072529.2TLR2, TLR4
28response to lipopolysaccharideGO:0324969.2TLR4, IL23R, IL6
29positive regulation of NF-kappaB import into nucleusGO:0423469.0TLR2, TLR4
30positive regulation of inflammatory responseGO:0507299.0TLR2, IL2, TLR4
31negative regulation of interleukin-17 productionGO:0327009.0IFNG, TLR2, TLR4
32positive regulation of tumor necrosis factor productionGO:0327608.9TLR4, TLR2, IFNG
33positive regulation of chemokine productionGO:0327228.9IL6, TLR2, TLR4
34positive regulation of interleukin-6 productionGO:0327558.9TLR4, IL6, TLR2
35positive regulation of interleukin-12 productionGO:0327358.7IL23R, IFNG, TLR4, TLR2
36positive regulation of NF-kappaB transcription factor activityGO:0510928.6TLR4, TLR2, TNFSF11, IL6
37positive regulation of nitric oxide biosynthetic processGO:0454298.5IL6, IFNG, TLR2, TLR4
38inflammatory responseGO:0069548.3IL23R, IL8, IL17C, TLR2, IL6
39immune responseGO:0069558.0IL8, TLR2, TLR4, IL2, IL4, TNFSF11
40positive regulation of transcription from RNA polymerase II promoterGO:0459447.5IL4, TNFSF11, IFNG, TLR2, IL2, IL6

Molecular functions related to Enthesitis-Related Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-6 receptor bindingGO:0051389.7ERAP1, IL6
2lipopolysaccharide receptor activityGO:0018758.7TLR2, TLR4
3cytokine activityGO:0051257.9IL17C, IFNG, IL2, IL6, IL4, TNFSF11

Products for genes affiliated with Enthesitis-Related Arthritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Enthesitis-Related Arthritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet