MCID: ENT010
MIFTS: 19

Enthesitis-Related Juvenile Idiopathic Arthritis malady

Categories: Rare diseases, Eye diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Enthesitis-Related Juvenile Idiopathic Arthritis

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Sources:
30ICD10 via Orphanet, 47NIH Rare Diseases, 53Orphanet, 67UMLS
See all MalaCards sources

Aliases & Descriptions for Enthesitis-Related Juvenile Idiopathic Arthritis:

Name: Enthesitis-Related Juvenile Idiopathic Arthritis 47
Enthesitis-Related Arthritis 47 53 67
Era 47 53
 
Enthesitis Related Arthritis, Juvenile 47
Juvenile Enthesitis-Related Arthritis 47
Juvenile Spondylarthropathy 47

Characteristics:

Orphanet epidemiological data:

53
enthesitis-related arthritis:
Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet53 ORPHA85438
ICD10 via Orphanet30 M08.8

Summaries for Enthesitis-Related Juvenile Idiopathic Arthritis

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MalaCards based summary: Enthesitis-Related Juvenile Idiopathic Arthritis, also known as enthesitis-related arthritis, is related to spondylarthropathy and rheumatoid arthritis, and has symptoms including arthritis, joint swelling and inflammatory abnormality of the eye. Affiliated tissues include eye and bone.

Related Diseases for Enthesitis-Related Juvenile Idiopathic Arthritis

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Diseases related to Enthesitis-Related Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1spondylarthropathy10.0
2rheumatoid arthritis9.9
3arthritis9.9

Symptoms for Enthesitis-Related Juvenile Idiopathic Arthritis

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Human phenotypes related to Enthesitis-Related Juvenile Idiopathic Arthritis:

 63 53 (show all 14)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthritis63 hallmark (90%) HP:0001369
2 joint swelling63 53 hallmark (90%) Very frequent (99-80%) HP:0001386
3 inflammatory abnormality of the eye63 hallmark (90%) HP:0100533
4 abnormality of the teeth63 typical (50%) HP:0000164
5 enthesitis63 53 typical (50%) Frequent (79-30%) HP:0100686
6 cartilage destruction63 53 typical (50%) Frequent (79-30%) HP:0100773
7 abnormal tendon morphology63 occasional (7.5%) HP:0100261
8 dental malocclusion53 Frequent (79-30%)
9 elevated erythrocyte sedimentation rate53 Very frequent (99-80%)
10 juvenile rheumatoid arthritis53 Very frequent (99-80%)
11 elevated c-reactive protein level53 Very frequent (99-80%)
12 anterior uveitis53 Very frequent (99-80%)
13 sacroiliac arthritis53 Very frequent (99-80%)
14 increased inflammatory response53 Very frequent (99-80%)

Drugs & Therapeutics for Enthesitis-Related Juvenile Idiopathic Arthritis

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Drugs for Enthesitis-Related Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AdalimumabapprovedPhase 3478331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
2
Etanerceptapproved, investigationalPhase 3397185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
3
Tofacitinibapproved, investigationalPhase 3104477600-75-2
Synonyms:
 
Tasocitinib
Tofacitinibum
4
Certolizumab pegolapprovedPhase 3122428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
D03441
cimzia
5Immunosuppressive AgentsPhase 312770
6Antirheumatic AgentsPhase 310627
7Peripheral Nervous System AgentsPhase 322776
8Gastrointestinal AgentsPhase 38109
9AnalgesicsPhase 311287
10Anti-Inflammatory AgentsPhase 310355
11Analgesics, Non-NarcoticPhase 36260
12Anti-Inflammatory Agents, Non-SteroidalPhase 34295
13Pharmaceutical SolutionsPhase 37793
14Protein Kinase InhibitorsPhase 33612
15Rheumatoid Factor6

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of the Efficacy and Safety of Adalimumab in Pediatric Subjects With Enthesitis Related ArthritisCompletedNCT01166282Phase 3
2Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisCompletedNCT00962741Phase 3
3Long-Term Safety Study Of Tofacinib In Patients With Juvenile Idiopathic ArthritisRecruitingNCT01500551Phase 3
4Extension Study Evaluating Etanercept in 3 Subtypes of Childhood ArthritisActive, not recruitingNCT01421069Phase 3
5Pediatric Arthritis Study of Certolizumab PegolActive, not recruitingNCT01550003Phase 3
6Secukinumab Safety and Efficacy in JPsA and ERANot yet recruitingNCT03031782Phase 3
7Juvenile Arthritis Quantitative ImagingRecruitingNCT02684695
8Natural History and Development of SpondyloarthritisRecruitingNCT01422694
9Observational Study of Pediatric Rheumatic Diseases: The CARRA RegistryRecruitingNCT02418442

Search NIH Clinical Center for Enthesitis-Related Juvenile Idiopathic Arthritis

Genetic Tests for Enthesitis-Related Juvenile Idiopathic Arthritis

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Anatomical Context for Enthesitis-Related Juvenile Idiopathic Arthritis

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MalaCards organs/tissues related to Enthesitis-Related Juvenile Idiopathic Arthritis:

35
Eye, Bone

Animal Models for Enthesitis-Related Juvenile Idiopathic Arthritis or affiliated genes

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Publications for Enthesitis-Related Juvenile Idiopathic Arthritis

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Variations for Enthesitis-Related Juvenile Idiopathic Arthritis

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Expression for genes affiliated with Enthesitis-Related Juvenile Idiopathic Arthritis

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Search GEO for disease gene expression data for Enthesitis-Related Juvenile Idiopathic Arthritis.

Pathways for genes affiliated with Enthesitis-Related Juvenile Idiopathic Arthritis

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GO Terms for genes affiliated with Enthesitis-Related Juvenile Idiopathic Arthritis

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Sources for Enthesitis-Related Juvenile Idiopathic Arthritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet