ERA
MCID: ENT010
MIFTS: 21

Enthesitis-Related Juvenile Idiopathic Arthritis (ERA) malady

Categories: Rare diseases, Eye diseases, Respiratory diseases, Bone diseases

Aliases & Classifications for Enthesitis-Related Juvenile Idiopathic Arthritis

Aliases & Descriptions for Enthesitis-Related Juvenile Idiopathic Arthritis:

Name: Enthesitis-Related Juvenile Idiopathic Arthritis 50 56
Enthesitis-Related Arthritis 50 69
Enthesitis-Related Jia 50 56
Era 50 56
Enthesitis Related Arthritis, Juvenile 50
Juvenile Enthesitis-Related Arthritis 50
Juvenile Spondylarthropathy 50

Characteristics:

Orphanet epidemiological data:

56
enthesitis-related juvenile idiopathic arthritis
Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 56 ORPHA85438
ICD10 via Orphanet 34 M08.8

Summaries for Enthesitis-Related Juvenile Idiopathic Arthritis

NIH Rare Diseases : 50 enthesitis-related juvenile idiopathic arthritis is a subtype of juvenile idiopathic arthritis that is characterized by both arthritis and inflammation of an enthesitis site (the point at which a ligament, tendon, or joint capsule attaches to the bone). signs and symptoms generally develop in late childhood or early adolescence and include pain, tenderness, and swelling in joints and at the enthesis. the knee and the back of the ankle (at the achilles tendon) are the most commonly affected parts of the body. the underlying cause of enthesitis-related juvenile idiopathic arthritis is currently unknown (idiopathic). it is very rare for more than one member of a family to have juvenile arthritis; however, research suggests that having a family member with juvenile arthritis or any autoimmune disease may increase the risk of having juvenile arthritis, in general. treatment usually involves different types of medications to help manage symptoms and/or physical therapy. last updated: 11/23/2015

MalaCards based summary : Enthesitis-Related Juvenile Idiopathic Arthritis, also known as enthesitis-related arthritis, is related to arthritis and spondylarthropathy, and has symptoms including joint swelling, dental malocclusion and elevated c-reactive protein level. The drugs Adalimumab and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include bone and eye.

Related Diseases for Enthesitis-Related Juvenile Idiopathic Arthritis

Diseases related to Enthesitis-Related Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 arthritis 10.0
2 spondylarthropathy 10.0
3 rheumatoid arthritis 9.9

Symptoms & Phenotypes for Enthesitis-Related Juvenile Idiopathic Arthritis

Human phenotypes related to Enthesitis-Related Juvenile Idiopathic Arthritis:

56 32 (show all 10)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 joint swelling 56 32 Very frequent (99-80%) HP:0001386
2 dental malocclusion 56 32 Frequent (79-30%) HP:0000689
3 elevated c-reactive protein level 56 32 Very frequent (99-80%) HP:0011227
4 cartilage destruction 56 32 Frequent (79-30%) HP:0100773
5 elevated erythrocyte sedimentation rate 56 32 Very frequent (99-80%) HP:0003565
6 enthesitis 56 32 Frequent (79-30%) HP:0100686
7 juvenile rheumatoid arthritis 56 32 Very frequent (99-80%) HP:0005681
8 anterior uveitis 56 32 Very frequent (99-80%) HP:0012122
9 sacroiliac arthritis 56 32 Very frequent (99-80%) HP:0012317
10 increased inflammatory response 56 Very frequent (99-80%)

Drugs & Therapeutics for Enthesitis-Related Juvenile Idiopathic Arthritis

Drugs for Enthesitis-Related Juvenile Idiopathic Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 3 331731-18-1 16219006
2
Etanercept Approved, Investigational Phase 3 185243-69-0
3
Tofacitinib Approved, Investigational Phase 3 477600-75-2
4
Certolizumab pegol Approved Phase 3 428863-50-7
5 Analgesics Phase 3
6 Gastrointestinal Agents Phase 3
7 Analgesics, Non-Narcotic Phase 3
8 Peripheral Nervous System Agents Phase 3
9 Pharmaceutical Solutions Phase 3
10 Immunosuppressive Agents Phase 3
11 Anti-Inflammatory Agents Phase 3
12 Anti-Inflammatory Agents, Non-Steroidal Phase 3
13 Antirheumatic Agents Phase 3
14 Protein Kinase Inhibitors Phase 3
15 Immunoglobulins Phase 3
16 Antibodies, Monoclonal Phase 3
17 Antibodies Phase 3
18 Rheumatoid Factor

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Study of the Efficacy and Safety of Adalimumab in Pediatric Subjects With Enthesitis Related Arthritis Completed NCT01166282 Phase 3
2 Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Completed NCT00962741 Phase 3
3 Long-Term Safety Study Of Tofacinib In Patients With Juvenile Idiopathic Arthritis Recruiting NCT01500551 Phase 3
4 Extension Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis Active, not recruiting NCT01421069 Phase 3
5 Pediatric Arthritis Study of Certolizumab Pegol Active, not recruiting NCT01550003 Phase 3
6 Secukinumab Safety and Efficacy in JPsA and ERA Not yet recruiting NCT03031782 Phase 3
7 Juvenile Arthritis Quantitative Imaging Recruiting NCT02684695
8 Natural History and Development of Spondyloarthritis Recruiting NCT01422694
9 Observational Study of Pediatric Rheumatic Diseases: The CARRA Registry Recruiting NCT02418442

Search NIH Clinical Center for Enthesitis-Related Juvenile Idiopathic Arthritis

Genetic Tests for Enthesitis-Related Juvenile Idiopathic Arthritis

Anatomical Context for Enthesitis-Related Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Enthesitis-Related Juvenile Idiopathic Arthritis:

39
Bone, Eye

Publications for Enthesitis-Related Juvenile Idiopathic Arthritis

Variations for Enthesitis-Related Juvenile Idiopathic Arthritis

Expression for Enthesitis-Related Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Enthesitis-Related Juvenile Idiopathic Arthritis.

Pathways for Enthesitis-Related Juvenile Idiopathic Arthritis

GO Terms for Enthesitis-Related Juvenile Idiopathic Arthritis

Sources for Enthesitis-Related Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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