Aliases & Classifications for Enthesopathy

MalaCards integrated aliases for Enthesopathy:

Name: Enthesopathy 12 14 69
Rheumatic Diseases 42
Rheumatism 69

Classifications:



External Ids:

Disease Ontology 12 DOID:204
ICD10 33 M77.9 M76.9
ICD9CM 35 726.9 726.90
MeSH 42 D012216
UMLS 69 C0242490

Summaries for Enthesopathy

MalaCards based summary : Enthesopathy, also known as rheumatic diseases, is related to diffuse idiopathic skeletal hyperostosis and jacobsen syndrome, and has symptoms including musculoskeletal symptom, myalgia and joint symptom. An important gene associated with Enthesopathy is PHEX (Phosphate Regulating Endopeptidase Homolog, X-Linked). The drugs Etanercept and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and kidney, and related phenotype is growth/size/body region.

Wikipedia : 72 In medicine, an enthesopathy refers to a disorder involving the attachment of a tendon or ligament to a... more...

Related Diseases for Enthesopathy

Diseases related to Enthesopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Related Disease Score Top Affiliating Genes
1 diffuse idiopathic skeletal hyperostosis 11.2
2 jacobsen syndrome 10.5 FGF23 PHEX
3 epicondylitis 10.4
4 fatal infantile encephalomyopathy 10.4 FGF23 PHEX
5 peroxisome biogenesis disorder 2a 10.4 FGF23 PHEX
6 atelosteogenesis 10.4 FGF23 PHEX
7 colorectal cancer, hereditary nonpolyposis, type 4 10.3 DMP1 FGF23
8 skin granular cell tumor 10.3 MRAP PHEX
9 tick-borne relapsing fever 10.2 MRAP PHB2
10 astrakhan spotted fever 10.2 FGF23 PHEX
11 plasmodium falciparum malaria 10.2 MRAP PHB2
12 urticaria 10.2 MRAP PHB2
13 neuronal ceroid-lipofuscinoses 10.2 MRAP PHB2
14 basilar artery occlusion 10.2 MRAP PHB2
15 caplan's syndrome 10.1 MEFV MRAP
16 bone deterioration disease 10.1 FGF23 PHEX
17 subserous uterine fibroid 10.1 FGF23 PHEX
18 arthritis 10.1
19 patau syndrome 10.1 MEFV MRAP
20 vulvar sarcoma 10.1 MRAP PHB2
21 arthropathy 10.1
22 psoriasis 10.1
23 hairy tongue 10.1 MRAP PHB2
24 childhood absence epilepsy 10.0 FGF23 PHEX
25 spondylitis 10.0
26 ophn1 syndrome 10.0 DMP1 FGF23 PHEX
27 psoriatic arthritis 10.0
28 osteoarthritis 10.0
29 spastic ataxia 10.0 DMP1 FGF23 PHEX
30 coffin-lowry syndrome 10.0 DMP1 FGF23 PHEX
31 gastric antral vascular ectasia 10.0 DMP1 FGF23 PHEX
32 prostate cancer, hereditary, x-linked 2 10.0 DMP1 FGF23 PHEX
33 charcot-marie-tooth disease, type 4k 10.0 DMP1 FGF23 PHEX
34 mild pre-eclampsia 10.0 DMP1 FGF23 PHEX
35 commensal bacterial infectious disease 10.0 DMP1 FGF23 PHEX
36 protein-losing enteropathy 10.0 DMP1 FGF23 PHEX
37 hypophosphatemia 9.9
38 spondyloarthropathy 9.9
39 hyperostosis 9.9
40 patellar tendinitis 9.9
41 tendinitis 9.9
42 heel spur 9.9
43 periarthritis 9.9
44 tendinopathy 9.8
45 achilles bursitis 9.7
46 nail disease 9.7
47 fasciitis 9.7
48 plantar fasciitis 9.7
49 spondylarthropathy 9.7
50 synovitis 9.7

Comorbidity relations with Enthesopathy via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Enthesopathy:



Diseases related to Enthesopathy

Symptoms & Phenotypes for Enthesopathy

UMLS symptoms related to Enthesopathy:


musculoskeletal symptom, myalgia, joint symptom

MGI Mouse Phenotypes related to Enthesopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 DMP1 FGF23 MEFV PHB2 PHEX SERPINI2

Drugs & Therapeutics for Enthesopathy

Drugs for Enthesopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4 185243-69-0
2 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
3 Analgesics Phase 4,Phase 3
4 Gastrointestinal Agents Phase 4
5 Analgesics, Non-Narcotic Phase 4,Phase 3
6 Immunosuppressive Agents Phase 4,Phase 3
7 Anti-Inflammatory Agents Phase 4,Phase 3
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
9 Antirheumatic Agents Phase 4,Phase 3
10
Lidocaine Approved, Vet_approved Phase 2, Phase 3,Phase 1 137-58-6 3676
11
Apremilast Approved, Investigational Phase 3 608141-41-9 11561674
12 Central Nervous System Depressants Phase 2, Phase 3,Phase 1
13 Sodium Channel Blockers Phase 2, Phase 3,Phase 1
14 Anesthetics Phase 2, Phase 3,Phase 1
15 Anesthetics, Local Phase 2, Phase 3,Phase 1
16 Diuretics, Potassium Sparing Phase 2, Phase 3,Phase 1
17 Anti-Arrhythmia Agents Phase 2, Phase 3,Phase 1
18 Angiogenesis Inhibitors Phase 3
19 Angiogenesis Modulating Agents Phase 3
20 Anti-Bacterial Agents Phase 3
21 Anti-Infective Agents Phase 3
22
Iodine Investigational 7553-56-2 807
23 cadexomer iodine
24 Mitogens
25 Hormones
26 Performance-Enhancing Substances

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
2 Treatment for Achilles Tendinopathy Unknown status NCT00835939 Phase 2, Phase 3 25% Dextrose and 1% Lidocaine;Lidocaine
3 Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA) Active, not recruiting NCT01307423 Phase 3 Apremilast 20mg;Apremilast 30mg;Placebo
4 Effectiveness of Dextrose Injection for Osgood-Schlatter Disease Completed NCT01300754 Phase 1, Phase 2
5 Comparison of the Effect of Radial Shock Wave, Ultrasound-guided Needle Puncture, and Combination of Both in the Treatment of Calcific Tendinitis of the Shoulder Completed NCT02677103
6 Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections Completed NCT01200875
7 Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis Recruiting NCT02962271
8 Distal Erosions and Nail Psoriasis Recruiting NCT02813720
9 Treatment of Acute and Chronic Ligament and Tendon Injuries With Platelet Rich Plasma Recruiting NCT01406821
10 Inflammatory Back Pain and Gluten Free Diet Not yet recruiting NCT03017716

Search NIH Clinical Center for Enthesopathy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: rheumatic diseases

Genetic Tests for Enthesopathy

Anatomical Context for Enthesopathy

MalaCards organs/tissues related to Enthesopathy:

39
Bone, Skin, Kidney

Publications for Enthesopathy

Articles related to Enthesopathy:

(show top 50) (show all 152)
id Title Authors Year
1
Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function. ( 28358891 )
2017
2
X-linked hypophosphatemia with enthesopathy. ( 28784895 )
2017
3
Subclinical enthesopathy in patients with psoriasis and its association with other disease parameters: a power Doppler ultrasonographic study. ( 28293449 )
2017
4
Presence of enthesopathy in patients with primary Sjogren's syndrome: ultrasonographic study of a local cohort. ( 28646319 )
2017
5
Intratissue percutaneous electolysis combined with active physical therapy for the treatment of adductor longus enthesopathy-related groin pain: a randomized trial. ( 28116876 )
2017
6
Ultrasonographic Enthesopathy and Disease Activity in Psoriatic Arthritis. ( 28932308 )
2017
7
Enthesopathy of the Extensor Carpi Radialis Brevis Origin: Effective Communication Strategies. ( 27077478 )
2016
8
A preliminary study showing that ultrasonography cannot differentiate between psoriatic arthritis and nodal osteoarthritis based on enthesopathy scores. ( 27179103 )
2016
9
Factors associated with operative treatment of enthesopathy of the extensor carpi radialis brevis origin. ( 26995457 )
2016
10
Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis. ( 27932277 )
2016
11
Nail involvement can predict enthesopathy in patients with psoriasis. ( 27860304 )
2016
12
Voriconazole-Induced Periostitis & Enthesopathy in Solid Organ Transplant Patients: Case Reports. ( 27990445 )
2016
13
Controversies in Surgical Management of Recalcitrant Enthesopathy of the Extensor Carpi Radialis Brevis. ( 27491631 )
2016
14
Investigation of Enthesopathy with Ultrasonography and Comparison with Skin Findings in Asymptomatic Psoriatic Patients. ( 27028326 )
2016
15
A radiological study on intra- and extra-cranial calcifications in adults with X-linked hypophosphatemia and associations with other mineralizing enthesopathies and childhood medical treatment. ( 26913700 )
2016
16
A Meta-Analysis of the Effect of Corticosteroid Injection for Enthesopathy of the Extensor Carpi Radialis Brevis Origin. ( 27546443 )
2016
17
Presence of enthesopathy demonstrated with ultrasonography in systemic sclerosis. ( 25736366 )
2015
18
P113. Subclinical Ultrasonographic Enthesopathy and Synovitis in patients with Inflammatory Bowel Disease (IBD) without clinical signs or symptoms of Spondyloarthritis. ( 25717572 )
2015
19
Pelvic enthesopathy on CT is significantly more prevalent in patients with diffuse idiopathic skeletal hyperostosis (DISH) compared with matched control patients. ( 26686367 )
2015
20
Conventional Therapy in Adults With X-Linked Hypophosphatemia: Effects on Enthesopathy and Dental Disease. ( 26176801 )
2015
21
Conventional Therapy in Adults With XLH Improves Dental Manifestations, But Not Enthesopathy. ( 26439151 )
2015
22
Persistent Pain After Surgery for Enthesopathy of the Extensor Carpi Radialis Brevis Origin. ( 25796379 )
2015
23
Enthesopathy of the pectoralis major tendon mimicking osteoid osteoma. A case report with an unfortunate series of events. ( 26605199 )
2015
24
Role of sonography and magnetic resonance imaging in detecting deltoideal acromial enthesopathy: an early finding in the diagnosis of spondyloarthritis and an under-recognized cause of posterior shoulder pain. ( 24658935 )
2014
25
Metabolic syndrome associated to non-inflammatory Achilles enthesopathy. ( 24535409 )
2014
26
The short-term effect after a single injection of high-molecular-weight hyaluronic acid in patients with enthesopathies (lateral epicondylitis, patellar tendinopathy, insertional Achilles tendinopathy, and plantar fasciitis): a preliminary study. ( 24817495 )
2014
27
The pisotriquetral joint: osteoarthritis and enthesopathy. ( 24876685 )
2014
28
The enthesopathy of celiac patients: effects of gluten-free diet. ( 24567238 )
2014
29
Exertional leg pain in familial mediterranean Fever: a manifestation of an underlying enthesopathy and a marker of more severe disease. ( 25223248 )
2014
30
Enthesopathy of the lateral cord of the plantar fascia. ( 25154957 )
2014
31
Treatment of Catastrophic Infection After Surgery for Insertional Achilles Enthesopathy: A Case Report and Review of the Literature. ( 25142918 )
2014
32
Enthesopathy in patients with familial Mediterranean fever: increased prevalence in M694 V variant. ( 23334425 )
2013
33
COMPUTED TOMOGRAPHY OF CANINE ELBOW JOINTS AFFECTED BY PRIMARY AND CONCOMITANT FLEXOR ENTHESOPATHY. ( 24033837 )
2013
34
The occurrence of lower limb enthesopathy in coeliac disease patients without clinical signs of articular involvement. ( 23300330 )
2013
35
Avulsion fragmentation of the tibial tuberosity apophysis and associated patellar tendon enthesopathy in a skeletally immature dog. ( 23677126 )
2013
36
Radiographic features of primary and concomitant flexor enthesopathy in the canine elbow. ( 23094825 )
2013
37
The use of the HiSPECT bone scan in canine flexor enthesopathy and coronoid pathology. ( 23375664 )
2013
38
Arthroscopic features of primary and concomitant flexor enthesopathy in the canine elbow. ( 23708890 )
2013
39
Assessment of enthesopathy in patients with fibromyalgia by using new sonographic enthesitis index. ( 24217664 )
2013
40
Transcatheter arterial embolization using imipenem/cilastatin sodium for tendinopathy and enthesopathy refractory to nonsurgical management. ( 23707086 )
2013
41
Increased enthesopathy in patients with familial Mediterranean fever: evaluation with a new sonographic enthesitis index. ( 23341390 )
2013
42
MAGNETIC RESONANCE IMAGING OF PRIMARY AND CONCOMITANT FLEXOR ENTHESOPATHY IN THE CANINE ELBOW. ( 24033814 )
2013
43
Poncet's disease: a symmetric seronegative polyarthritis with enthesopathy refractory to the therapy. ( 24149016 )
2013
44
Enthesopathy and desmitis of the medial collateral ligament of the cubital joint in 4 horses. ( 23547681 )
2013
45
Does enthesopathy relate to M694V gene mutation in patients with Familial Mediterranean fever? ( 23812619 )
2013
46
Autologous blood and platelet-rich plasma injections for enthesopathy of the extensor carpi radialis brevis origin. ( 23455408 )
2013
47
The use of planar bone scintigraphy and HiSPECT for diagnosis of primary and concomitant flexor enthesopathy in the canine elbow. ( 23801368 )
2013
48
Primary and concomitant flexor enthesopathy of the canine elbow. ( 23801308 )
2013
49
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. ( 22156725 )
2012
50
Ultrasound revealing subclinical enthesopathy at the greater trochanter level in patients with spondyloarthritis. ( 22015936 )
2012

Variations for Enthesopathy

Expression for Enthesopathy

Search GEO for disease gene expression data for Enthesopathy.

Pathways for Enthesopathy

GO Terms for Enthesopathy

Biological processes related to Enthesopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 biomineral tissue development GO:0031214 9.26 DMP1 PHEX
2 cellular response to vitamin D GO:0071305 9.16 FGF23 PHEX
3 cellular response to parathyroid hormone stimulus GO:0071374 8.96 FGF23 PHEX
4 response to sodium phosphate GO:1904383 8.62 FGF23 PHEX

Sources for Enthesopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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