Aliases & Classifications for Enthesopathy

MalaCards integrated aliases for Enthesopathy:

Name: Enthesopathy 12 14 69
Rheumatic Diseases 41
Rheumatism 69

Classifications:



External Ids:

Disease Ontology 12 DOID:204
ICD10 32 M77.9 M76.9
ICD9CM 34 726.9 726.90
MeSH 41 D012216

Summaries for Enthesopathy

MalaCards based summary : Enthesopathy, also known as rheumatic diseases, is related to tendinitis and hypophosphatemia, and has symptoms including myalgia, joint symptom and musculoskeletal symptom. An important gene associated with Enthesopathy is PHEX (Phosphate Regulating Endopeptidase Homolog X-Linked). The drugs Etanercept and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and kidney, and related phenotype is growth/size/body region.

Wikipedia : 72 In medicine, an enthesopathy refers to a disorder involving the attachment of a tendon or ligament to a... more...

Related Diseases for Enthesopathy

Diseases related to Enthesopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 tendinitis 30.2 MRAP PHB2
2 hypophosphatemia 29.9 DMP1 FGF23 PHEX
3 bursitis 29.6 MRAP PHB2
4 diffuse idiopathic skeletal hyperostosis 11.3
5 epicondylitis 10.5
6 opsismodysplasia 10.3 FGF23 PHEX
7 familial tumoral calcinosis 10.3 FGF23 PHEX
8 hypophosphatemic rickets, autosomal dominant 10.3 FGF23 PHEX
9 arterial calcification of infancy 10.2 FGF23 PHEX
10 arthritis 10.2
11 raine syndrome 10.2 DMP1 FGF23
12 iris disease 10.2 MRAP PHEX
13 arthropathy 10.2
14 pustulosis of palm and sole 10.2
15 psoriasis 10.2
16 spondyloarthropathy 1 10.1
17 inflammatory spondylopathy 10.1
18 spondylitis 10.1
19 mineral metabolism disease 10.1 FGF23 PHEX
20 balanitis 10.1 MRAP PHB2
21 iritis 10.1 MRAP PHB2
22 penile disease 10.1 MRAP PHB2
23 bone remodeling disease 10.1 FGF23 PHEX
24 byssinosis 10.1 MEFV MRAP
25 osteoarthritis with mild chondrodysplasia 10.1
26 psoriatic arthritis 10.1
27 episodic pain syndrome, familial, 1 10.1
28 osteoarthritis 10.1
29 urethritis 10.1 MRAP PHB2
30 transient arthritis 10.1 MRAP PHB2
31 hyperostosis 10.1
32 palindromic rheumatism 10.1 MEFV MRAP
33 calcinosis 10.1 FGF23 PHEX
34 urethral syndrome 10.0 MRAP PHB2
35 spondyloarthropathy 10.0
36 periarthritis 10.0
37 conjunctival disease 10.0 MRAP PHB2
38 familial mediterranean fever 10.0
39 brucellosis 10.0
40 oncogenic osteomalacia 10.0 DMP1 FGF23 PHEX
41 autosomal recessive hypophosphatemic rickets 10.0 DMP1 FGF23 PHEX
42 hypophosphatemic rickets, x-linked dominant 10.0 DMP1 FGF23 PHEX
43 phosphorus metabolism disease 9.9 DMP1 FGF23 PHEX
44 hypophosphatemic rickets, x-linked recessive 9.9 DMP1 FGF23 PHEX
45 hypophosphatemic rickets with hypercalciuria, hereditary 9.9 DMP1 FGF23 PHEX
46 osteomalacia 9.9 DMP1 FGF23 PHEX
47 rickets 9.9 DMP1 FGF23 PHEX
48 tendinopathy 9.9
49 patellar tendinitis 9.9
50 achilles bursitis 9.9

Comorbidity relations with Enthesopathy via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Enthesopathy:



Diseases related to Enthesopathy

Symptoms & Phenotypes for Enthesopathy

UMLS symptoms related to Enthesopathy:


myalgia, joint symptom, musculoskeletal symptom

MGI Mouse Phenotypes related to Enthesopathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 DMP1 FGF23 MEFV PHB2 PHEX SERPINI2

Drugs & Therapeutics for Enthesopathy

Drugs for Enthesopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4 185243-69-0
2 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
3 Analgesics Phase 4,Phase 3
4 Analgesics, Non-Narcotic Phase 4,Phase 3
5 Anti-Inflammatory Agents Phase 4,Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
7 Antirheumatic Agents Phase 4,Phase 3
8 Gastrointestinal Agents Phase 4
9 Immunosuppressive Agents Phase 4,Phase 3
10
Lidocaine Approved, Vet_approved Phase 2, Phase 3,Phase 1 137-58-6 3676
11
Apremilast Approved, Investigational Phase 3 608141-41-9 11561674
12 Anesthetics Phase 2, Phase 3,Phase 1
13 Anesthetics, Local Phase 2, Phase 3,Phase 1
14 Anti-Arrhythmia Agents Phase 2, Phase 3,Phase 1
15 Central Nervous System Depressants Phase 2, Phase 3,Phase 1
16 Diuretics, Potassium Sparing Phase 2, Phase 3,Phase 1
17 Sodium Channel Blockers Phase 2, Phase 3,Phase 1
18 Angiogenesis Inhibitors Phase 3
19 Angiogenesis Modulating Agents Phase 3
20 Anti-Bacterial Agents Phase 3
21 Anti-Infective Agents Phase 3
22
Iodine Approved, Investigational 7553-56-2 807
23 cadexomer iodine
24 Hormones
25 Mitogens
26 Performance-Enhancing Substances

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
2 Treatment for Achilles Tendinopathy Unknown status NCT00835939 Phase 2, Phase 3 25% Dextrose and 1% Lidocaine;Lidocaine
3 Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA) Active, not recruiting NCT01307423 Phase 3 Apremilast 20mg;Apremilast 30mg;Placebo
4 Effectiveness of Dextrose Injection for Osgood-Schlatter Disease Completed NCT01300754 Phase 1, Phase 2
5 Comparison of the Effect of Radial Shock Wave, Ultrasound-guided Needle Puncture, and Combination of Both in the Treatment of Calcific Tendinitis of the Shoulder Completed NCT02677103
6 Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections Completed NCT01200875
7 Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis Recruiting NCT02962271
8 Distal Erosions and Nail Psoriasis Recruiting NCT02813720
9 Treatment of Acute and Chronic Ligament and Tendon Injuries With Platelet Rich Plasma Recruiting NCT01406821
10 Inflammatory Back Pain and Gluten Free Diet Not yet recruiting NCT03017716

Search NIH Clinical Center for Enthesopathy

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: rheumatic diseases

Genetic Tests for Enthesopathy

Anatomical Context for Enthesopathy

MalaCards organs/tissues related to Enthesopathy:

38
Bone, Skin, Kidney

Publications for Enthesopathy

Articles related to Enthesopathy:

(show top 50) (show all 156)
# Title Authors Year
1
Aberrant TGF-I^ activation in bone tendon insertion induces enthesopathy-like disease. ( 29355842 )
2018
2
Subclinical enthesopathy in patients with psoriasis and its association with other disease parameters: a power Doppler ultrasonographic study. ( 28293449 )
2017
3
Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function. ( 28358891 )
2017
4
Clinical and ultrasonographic enthesopathy in inflammatory rheumatic diseases : Is MASEI or only calcaneal enthesitis sufficient? ( 29116386 )
2017
5
Enthesopathy in rheumatoid arthritis and spondyloarthritis: An ultrasound study. ( 29233691 )
2017
6
X-linked hypophosphatemia with enthesopathy. ( 28784895 )
2017
7
Presence of enthesopathy in patients with primary Sjogren's syndrome: ultrasonographic study of a local cohort. ( 28646319 )
2017
8
Ultrasonographic Enthesopathy and Disease Activity in Psoriatic Arthritis. ( 28932308 )
2017
9
Styloid Process Elongation on Cervical Spine Computed Tomography is Associated with the Enthesopathy-Related Diseases of Ankylosing Spondylitis and Diffuse Idiopathic Skeletal Hyperostosis. ( 29185278 )
2017
10
Intratissue percutaneous electolysis combined with active physical therapy for the treatment of adductor longus enthesopathy-related groin pain: a randomized trial. ( 28116876 )
2017
11
A Meta-Analysis of the Effect of Corticosteroid Injection for Enthesopathy of the Extensor Carpi Radialis Brevis Origin. ( 27546443 )
2016
12
Factors associated with operative treatment of enthesopathy of the extensor carpi radialis brevis origin. ( 26995457 )
2016
13
Investigation of Enthesopathy with Ultrasonography and Comparison with Skin Findings in Asymptomatic Psoriatic Patients. ( 27028326 )
2016
14
Nail involvement can predict enthesopathy in patients with psoriasis. ( 27860304 )
2016
15
A preliminary study showing that ultrasonography cannot differentiate between psoriatic arthritis and nodal osteoarthritis based on enthesopathy scores. ( 27179103 )
2016
16
Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis. ( 27932277 )
2016
17
A radiological study on intra- and extra-cranial calcifications in adults with X-linked hypophosphatemia and associations with other mineralizing enthesopathies and childhood medical treatment. ( 26913700 )
2016
18
Voriconazole-Induced Periostitis & Enthesopathy in Solid Organ Transplant Patients: Case Reports. ( 27990445 )
2016
19
Controversies in Surgical Management of Recalcitrant Enthesopathy of the Extensor Carpi Radialis Brevis. ( 27491631 )
2016
20
Enthesopathy of the Extensor Carpi Radialis Brevis Origin: Effective Communication Strategies. ( 27077478 )
2016
21
Enthesopathy of the pectoralis major tendon mimicking osteoid osteoma. A case report with an unfortunate series of events. ( 26605199 )
2015
22
Pelvic enthesopathy on CT is significantly more prevalent in patients with diffuse idiopathic skeletal hyperostosis (DISH) compared with matched control patients. ( 26686367 )
2015
23
Conventional Therapy in Adults With XLH Improves Dental Manifestations, But Not Enthesopathy. ( 26439151 )
2015
24
Conventional Therapy in Adults With X-Linked Hypophosphatemia: Effects on Enthesopathy and Dental Disease. ( 26176801 )
2015
25
Presence of enthesopathy demonstrated with ultrasonography in systemic sclerosis. ( 25736366 )
2015
26
Persistent Pain After Surgery for Enthesopathy of the Extensor Carpi Radialis Brevis Origin. ( 25796379 )
2015
27
P113. Subclinical Ultrasonographic Enthesopathy and Synovitis in patients with Inflammatory Bowel Disease (IBD) without clinical signs or symptoms of Spondyloarthritis. ( 25717572 )
2015
28
Exertional leg pain in familial mediterranean Fever: a manifestation of an underlying enthesopathy and a marker of more severe disease. ( 25223248 )
2014
29
Enthesopathy of the lateral cord of the plantar fascia. ( 25154957 )
2014
30
Treatment of Catastrophic Infection After Surgery for Insertional Achilles Enthesopathy: A Case Report and Review of the Literature. ( 25142918 )
2014
31
Metabolic syndrome associated to non-inflammatory Achilles enthesopathy. ( 24535409 )
2014
32
The short-term effect after a single injection of high-molecular-weight hyaluronic acid in patients with enthesopathies (lateral epicondylitis, patellar tendinopathy, insertional Achilles tendinopathy, and plantar fasciitis): a preliminary study. ( 24817495 )
2014
33
The enthesopathy of celiac patients: effects of gluten-free diet. ( 24567238 )
2014
34
Role of sonography and magnetic resonance imaging in detecting deltoideal acromial enthesopathy: an early finding in the diagnosis of spondyloarthritis and an under-recognized cause of posterior shoulder pain. ( 24658935 )
2014
35
The pisotriquetral joint: osteoarthritis and enthesopathy. ( 24876685 )
2014
36
The use of planar bone scintigraphy and HiSPECT for diagnosis of primary and concomitant flexor enthesopathy in the canine elbow. ( 23801368 )
2013
37
COMPUTED TOMOGRAPHY OF CANINE ELBOW JOINTS AFFECTED BY PRIMARY AND CONCOMITANT FLEXOR ENTHESOPATHY. ( 24033837 )
2013
38
Does enthesopathy relate to M694V gene mutation in patients with Familial Mediterranean fever? ( 23812619 )
2013
39
Autologous blood and platelet-rich plasma injections for enthesopathy of the extensor carpi radialis brevis origin. ( 23455408 )
2013
40
The occurrence of lower limb enthesopathy in coeliac disease patients without clinical signs of articular involvement. ( 23300330 )
2013
41
The use of the HiSPECT bone scan in canine flexor enthesopathy and coronoid pathology. ( 23375664 )
2013
42
Poncet's disease: a symmetric seronegative polyarthritis with enthesopathy refractory to the therapy. ( 24149016 )
2013
43
Transcatheter arterial embolization using imipenem/cilastatin sodium for tendinopathy and enthesopathy refractory to nonsurgical management. ( 23707086 )
2013
44
Assessment of enthesopathy in patients with fibromyalgia by using new sonographic enthesitis index. ( 24217664 )
2013
45
MAGNETIC RESONANCE IMAGING OF PRIMARY AND CONCOMITANT FLEXOR ENTHESOPATHY IN THE CANINE ELBOW. ( 24033814 )
2013
46
Enthesopathy and desmitis of the medial collateral ligament of the cubital joint in 4 horses. ( 23547681 )
2013
47
Enthesopathy in patients with familial Mediterranean fever: increased prevalence in M694 V variant. ( 23334425 )
2013
48
Arthroscopic features of primary and concomitant flexor enthesopathy in the canine elbow. ( 23708890 )
2013
49
Radiographic features of primary and concomitant flexor enthesopathy in the canine elbow. ( 23094825 )
2013
50
Primary and concomitant flexor enthesopathy of the canine elbow. ( 23801308 )
2013

Variations for Enthesopathy

Expression for Enthesopathy

Search GEO for disease gene expression data for Enthesopathy.

Pathways for Enthesopathy

GO Terms for Enthesopathy

Biological processes related to Enthesopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 biomineral tissue development GO:0031214 9.26 DMP1 PHEX
2 cellular response to vitamin D GO:0071305 9.16 FGF23 PHEX
3 cellular response to parathyroid hormone stimulus GO:0071374 8.96 FGF23 PHEX
4 response to sodium phosphate GO:1904383 8.62 FGF23 PHEX

Sources for Enthesopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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