Aliases & Classifications for Enthesopathy

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Summaries for Enthesopathy

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Wikipedia:71 In medicine, an enthesopathy refers to a disorder involving the attachment of a tendon or ligament to a... more...

MalaCards based summary: Enthesopathy, also known as rheumatic diseases, is related to hyperostosis and diffuse idiopathic skeletal hyperostosis, and has symptoms including pain in limb, sciatica and myalgia. An important gene associated with Enthesopathy is PHEX (Phosphate Regulating Endopeptidase Homolog, X-Linked). The drugs hydrocortisone and hydrocortisone acetate powder have been mentioned in the context of this disorder. Affiliated tissues include bone and skin, and related mouse phenotype growth/size/body region.

Related Diseases for Enthesopathy

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Diseases related to Enthesopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1hyperostosis26.2DMP1, FGF23, H19, MEFV, MRAP, PHB2
2diffuse idiopathic skeletal hyperostosis11.2
3epicondylitis10.4
4jacobsen syndrome10.4FGF23, PHEX
5familial wilms tumor 210.3FGF23, PHEX
6peroxisome biogenesis disorder 2a10.3FGF23, PHEX
7atelosteogenesis10.3FGF23, PHEX
8prostate cancer, hereditary, x-linked 210.2FGF23, PHEX
9colorectal cancer, hereditary nonpolyposis, type 410.2DMP1, FGF23
10loeys-dietz syndrome10.1FGF23, PHEX
11louse-borne relapsing fever10.1MRAP, PHB2
12acute diffuse nephritis10.1MRAP, PHB2
13arthritis10.1
14arthropathy10.1
15astrakhan spotted fever10.1FGF23, PHEX
16psoriasis10.1
17glanders10.1MRAP, PHB2
18nephrosclerosis10.1MEFV, MRAP
19spondylitis10.0
20benign vaginal carcinosarcoma10.0MRAP, PHB2
21osteoarthritis10.0
22bone deterioration disease10.0FGF23, PHEX
23psoriatic arthritis10.0
24onychotrichodysplasia and neutropenia10.0DMP1, FGF23, PHEX
25spastic ataxia10.0DMP1, FGF23, PHEX
26spondyloarthropathy9.9
27sensory peripheral neuropathy9.9DMP1, FGF23, PHEX
28brugada syndrome9.9DMP1, FGF23, PHEX
29commensal bacterial infectious disease9.9DMP1, FGF23, PHEX
30tuberous sclerosis-19.9DMP1, FGF23, PHEX
31leukodystrophy9.9DMP1, FGF23, PHEX
32protein-losing enteropathy9.9DMP1, FGF23, PHEX
33hypophosphatemia9.9
34tendinitis9.9
35patellar tendinitis9.9
36heel spur9.9
37periarthritis9.9
38xanthomatosis9.9MRAP, PHB2
39tendinopathy9.8
40status epilepticus9.8FGF23, PHEX
41renal artery obstruction9.8PHB2, SERPINI2
42synovitis9.7
43nail disease9.7
44fasciitis9.7
45plantar fasciitis9.7
46spondylarthropathy9.7
47achilles bursitis9.7
48leprosy9.6
49acne9.6
50primary biliary cirrhosis9.6

Comorbidity relations with Enthesopathy via Phenotypic Disease Network (PDN):


Hypertension, EssentialAcute Cystitis

Graphical network of the top 20 diseases related to Enthesopathy:



Diseases related to enthesopathy

Symptoms & Phenotypes for Enthesopathy

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UMLS symptoms related to Enthesopathy:


pain in limb, sciatica, myalgia, metatarsalgia, tenalgia, tendon discomfort

MGI Mouse Phenotypes related to Enthesopathy according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.5DMP1, FGF23, MEFV, PHB2, PHEX, SERPINI2

Drugs & Therapeutics for Enthesopathy

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Drugs for Enthesopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Etanerceptapproved, investigationalPhase 4397185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
2Peripheral Nervous System AgentsPhase 4, Phase 2, Phase 3, Phase 122776
3Immunosuppressive AgentsPhase 4, Phase 312770
4AnalgesicsPhase 4, Phase 311287
5Gastrointestinal AgentsPhase 48109
6Analgesics, Non-NarcoticPhase 4, Phase 36260
7Antirheumatic AgentsPhase 4, Phase 310627
8Anti-Inflammatory AgentsPhase 4, Phase 310355
9Anti-Inflammatory Agents, Non-SteroidalPhase 4, Phase 34295
10
Lidocaineapproved, vet_approvedPhase 2, Phase 3, Phase 11226137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bio-0767
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Cuivasil
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
DermaFlex
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gravocain
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
 
LS-805
Lanabiotic
Leostesin
Lida-Mantle
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocainum
Lidocainum [INN-Latin]
Lidocaton
Lidoderm
Lidoject-1
Lidoject-2
Lignocaine
Lignocainum
Lingocaine
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Octocaine
Octocaine-100
Octocaine-50
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-MPF
Xylocaine-MPF with Glucose
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
11
Apremilastapproved, investigationalPhase 364608141-41-911561674
Synonyms:
Apremilast
Apremilast (USAN)
Apremilastum
Aprémilast
CC-10004
 
CHEBI:558773
CHEMBL514800
CID11561674
D08860
N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide
N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
12Diuretics, Potassium SparingPhase 2, Phase 3, Phase 11827
13Sodium Channel BlockersPhase 2, Phase 3, Phase 11515
14Central Nervous System DepressantsPhase 2, Phase 3, Phase 112806
15Anti-Arrhythmia AgentsPhase 2, Phase 3, Phase 12969
16AnestheticsPhase 2, Phase 3, Phase 19001
17Anesthetics, LocalPhase 2, Phase 3, Phase 13272
18Anti-Bacterial AgentsPhase 310884
19Anti-Infective AgentsPhase 321402
20Angiogenesis Modulating AgentsPhase 34072
21Angiogenesis InhibitorsPhase 34143
22Mitogens1526
23Performance-Enhancing Substances2
24
Iodine5467553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
25cadexomer iodine514
26Hormones13979

Interventional clinical trials:

idNameStatusNCT IDPhase
1A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With SpondyloarthritisCompletedNCT02960035Phase 4
2Treatment for Achilles TendinopathyUnknown statusNCT00835939Phase 2, Phase 3
3Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA)Active, not recruitingNCT01307423Phase 3
4Effectiveness of Dextrose Injection for Osgood-Schlatter DiseaseCompletedNCT01300754Phase 1, Phase 2
5Comparison of the Effect of Radial Shock Wave, Ultrasound-guided Needle Puncture, and Combination of Both in the Treatment of Calcific Tendinitis of the ShoulderCompletedNCT02677103
6Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) InjectionsCompletedNCT01200875
7Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and PsoriasisRecruitingNCT02962271
8Distal Erosions and Nail PsoriasisRecruitingNCT02813720
9Treatment of Acute and Chronic Ligament and Tendon Injuries With Platelet Rich PlasmaRecruitingNCT01406821
10Inflammatory Back Pain and Gluten Free DietNot yet recruitingNCT03017716

Search NIH Clinical Center for Enthesopathy

Inferred drug relations via UMLS68/NDF-RT46:

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Cochrane evidence based reviews: rheumatic diseases

Genetic Tests for Enthesopathy

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Anatomical Context for Enthesopathy

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MalaCards organs/tissues related to Enthesopathy:

36
Bone, Skin

Publications for Enthesopathy

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Articles related to Enthesopathy:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Factors associated with operative treatment of enthesopathy of the extensor carpi radialis brevis origin. (26995457)
2016
2
A Meta-Analysis of the Effect of Corticosteroid Injection for Enthesopathy of the Extensor Carpi Radialis Brevis Origin. (27546443)
2016
3
Investigation of Enthesopathy with Ultrasonography and Comparison with Skin Findings in Asymptomatic Psoriatic Patients. (27028326)
2016
4
Nail involvement can predict enthesopathy in patients with psoriasis. (27860304)
2016
5
Enthesopathy of the Extensor Carpi Radialis Brevis Origin: Effective Communication Strategies. (27077478)
2016
6
Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis. (27932277)
2016
7
Voriconazole-Induced Periostitis & Enthesopathy in Solid Organ Transplant Patients: Case Reports. (27990445)
2016
8
Controversies in Surgical Management of Recalcitrant Enthesopathy of the Extensor Carpi Radialis Brevis. (27491631)
2016
9
A radiological study on intra- and extra-cranial calcifications in adults with X-linked hypophosphatemia and associations with other mineralizing enthesopathies and childhood medical treatment. (26913700)
2016
10
A preliminary study showing that ultrasonography cannot differentiate between psoriatic arthritis and nodal osteoarthritis based on enthesopathy scores. (27179103)
2016
11
Pelvic enthesopathy on CT is significantly more prevalent in patients with diffuse idiopathic skeletal hyperostosis (DISH) compared with matched control patients. (26686367)
2015
12
Conventional Therapy in Adults With XLH Improves Dental Manifestations, But Not Enthesopathy. (26439151)
2015
13
Enthesopathy of the pectoralis major tendon mimicking osteoid osteoma. A case report with an unfortunate series of events. (26605199)
2015
14
Presence of enthesopathy demonstrated with ultrasonography in systemic sclerosis. (25736366)
2015
15
P113. Subclinical Ultrasonographic Enthesopathy and Synovitis in patients with Inflammatory Bowel Disease (IBD) without clinical signs or symptoms of Spondyloarthritis. (25717572)
2015
16
Conventional Therapy in Adults With X-Linked Hypophosphatemia: Effects on Enthesopathy and Dental Disease. (26176801)
2015
17
Persistent Pain After Surgery for Enthesopathy of the Extensor Carpi Radialis Brevis Origin. (25796379)
2015
18
Enthesopathy of the lateral cord of the plantar fascia. (25154957)
2014
19
The enthesopathy of celiac patients: effects of gluten-free diet. (24567238)
2014
20
The pisotriquetral joint: osteoarthritis and enthesopathy. (24876685)
2014
21
Treatment of Catastrophic Infection After Surgery for Insertional Achilles Enthesopathy: A Case Report and Review of the Literature. (25142918)
2014
22
Exertional leg pain in familial mediterranean Fever: a manifestation of an underlying enthesopathy and a marker of more severe disease. (25223248)
2014
23
The short-term effect after a single injection of high-molecular-weight hyaluronic acid in patients with enthesopathies (lateral epicondylitis, patellar tendinopathy, insertional Achilles tendinopathy, and plantar fasciitis): a preliminary study. (24817495)
2014
24
Metabolic syndrome associated to non-inflammatory Achilles enthesopathy. (24535409)
2014
25
Role of sonography and magnetic resonance imaging in detecting deltoideal acromial enthesopathy: an early finding in the diagnosis of spondyloarthritis and an under-recognized cause of posterior shoulder pain. (24658935)
2014
26
The use of the HiSPECT bone scan in canine flexor enthesopathy and coronoid pathology. (23375664)
2013
27
Transcatheter arterial embolization using imipenem/cilastatin sodium for tendinopathy and enthesopathy refractory to nonsurgical management. (23707086)
2013
28
MAGNETIC RESONANCE IMAGING OF PRIMARY AND CONCOMITANT FLEXOR ENTHESOPATHY IN THE CANINE ELBOW. (24033814)
2013
29
Enthesopathy and desmitis of the medial collateral ligament of the cubital joint in 4 horses. (23547681)
2013
30
COMPUTED TOMOGRAPHY OF CANINE ELBOW JOINTS AFFECTED BY PRIMARY AND CONCOMITANT FLEXOR ENTHESOPATHY. (24033837)
2013
31
Assessment of enthesopathy in patients with fibromyalgia by using new sonographic enthesitis index. (24217664)
2013
32
Arthroscopic features of primary and concomitant flexor enthesopathy in the canine elbow. (23708890)
2013
33
Primary and concomitant flexor enthesopathy of the canine elbow. (23801308)
2013
34
The occurrence of lower limb enthesopathy in coeliac disease patients without clinical signs of articular involvement. (23300330)
2013
35
Enthesopathy in patients with familial Mediterranean fever: increased prevalence in M694 V variant. (23334425)
2013
36
Poncet's disease: a symmetric seronegative polyarthritis with enthesopathy refractory to the therapy. (24149016)
2013
37
Avulsion fragmentation of the tibial tuberosity apophysis and associated patellar tendon enthesopathy in a skeletally immature dog. (23677126)
2013
38
Increased enthesopathy in patients with familial Mediterranean fever: evaluation with a new sonographic enthesitis index. (23341390)
2013
39
Does enthesopathy relate to M694V gene mutation in patients with Familial Mediterranean fever? (23812619)
2013
40
The use of planar bone scintigraphy and HiSPECT for diagnosis of primary and concomitant flexor enthesopathy in the canine elbow. (23801368)
2013
41
Autologous blood and platelet-rich plasma injections for enthesopathy of the extensor carpi radialis brevis origin. (23455408)
2013
42
Radiographic features of primary and concomitant flexor enthesopathy in the canine elbow. (23094825)
2013
43
Ultrasonographic assessment of nail in psoriatic disease shows a link between onychopathy and distal interphalangeal joint extensor tendon enthesopathy. (23128597)
2012
44
Bone scan in enthesopathy involving tendo Achilles. (22228344)
2012
45
Lipopolysaccharide treatment suppresses spontaneously developing ankylosing enthesopathy in B10.BR male mice: the potential role of interleukin-10. (22721554)
2012
46
Relation of hand enthesophytes with knee enthesopathy: is osteoarthritis related to a systemic enthesopathy? (22174209)
2012
47
The puzzle of generalized osteoarthritis (OA) -- is OA a systemic enthesopathy? (22298259)
2012
48
Ultrasound revealing subclinical enthesopathy at the greater trochanter level in patients with spondyloarthritis. (22015936)
2012
49
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. (22156725)
2012
50
Primary flexor enthesopathy of the canine elbow: imaging and arthroscopic findings in eight dogs with discrete radiographic changes. (22451088)
2012

Variations for Enthesopathy

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Expression for genes affiliated with Enthesopathy

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Search GEO for disease gene expression data for Enthesopathy.

Pathways for genes affiliated with Enthesopathy

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GO Terms for genes affiliated with Enthesopathy

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Sources for Enthesopathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet