Aliases & Classifications for Enthesopathy

Aliases & Descriptions for Enthesopathy:

Name: Enthesopathy 12 14 69
Rheumatic Diseases 42
Rheumatism 69

Classifications:



External Ids:

Disease Ontology 12 DOID:204
ICD10 33 M77.9 M76.9
ICD9CM 35 726.9 726.90
MeSH 42 D012216
UMLS 69 C0242490

Summaries for Enthesopathy

MalaCards based summary : Enthesopathy, also known as rheumatic diseases, is related to diffuse idiopathic skeletal hyperostosis and epicondylitis, and has symptoms including musculoskeletal symptom, myalgia and joint symptom. An important gene associated with Enthesopathy is PHEX (Phosphate Regulating Endopeptidase Homolog, X-Linked). The drugs Etanercept and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include bone and skin, and related phenotype is growth/size/body region.

Wikipedia : 71 In medicine, an enthesopathy refers to a disorder involving the attachment of a tendon or ligament to a... more...

Related Diseases for Enthesopathy

Diseases related to Enthesopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Related Disease Score Top Affiliating Genes
1 diffuse idiopathic skeletal hyperostosis 11.2
2 epicondylitis 10.4
3 wiedemann-steiner syndrome 10.2 FGF23 PHEX
4 familial atrial fibrillation 10.2 FGF23 PHEX
5 peroxisome biogenesis disorder 2b 10.2 FGF23 PHEX
6 feigenbaum bergeron richardson syndrome 10.2 FGF23 PHEX
7 maroteaux stanescu cousin syndrome 10.2 FGF23 PHEX
8 ventricular tachycardia, catecholaminergic polymorphic, 3 10.1 DMP1 FGF23
9 skin granular cell tumor 10.1 MRAP PHEX
10 indian tick typhus 10.1 FGF23 PHEX
11 tick-borne relapsing fever 10.1 MRAP PHB2
12 plasmodium falciparum malaria 10.1 MRAP PHB2
13 arthritis 10.1
14 arthropathy 10.1
15 vibratory urticaria 10.1 MRAP PHB2
16 anthracosis 10.1 MEFV MRAP
17 childhood absence epilepsy 10.1 FGF23 PHEX
18 subserous uterine fibroid 10.1 FGF23 PHEX
19 basilar artery occlusion 10.1 MRAP PHB2
20 psoriasis 10.1
21 patau syndrome 10.1 MEFV MRAP
22 vulvar sarcoma 10.1 MRAP PHB2
23 hairy tongue 10.0 MRAP PHB2
24 spondylitis 10.0
25 ischemic bone disease 10.0 FGF23 PHEX
26 lymphangioleiomyomatosis 10.0 DMP1 FGF23 PHEX
27 opthalmoplegia mental retardation lingua scrotalis 10.0 DMP1 FGF23 PHEX
28 x-linked hereditary ataxia 10.0 DMP1 FGF23 PHEX
29 coffin-lowry syndrome 10.0 DMP1 FGF23 PHEX
30 gastric antral vascular ectasia 10.0 DMP1 FGF23 PHEX
31 prostate cancer, hereditary, x-linked 2 10.0 DMP1 FGF23 PHEX
32 opportunistic bacterial infectious disease 10.0 DMP1 FGF23 PHEX
33 osteoarthritis 10.0
34 pre-eclampsia 10.0 DMP1 FGF23 PHEX
35 allergic urticaria 10.0 DMP1 FGF23 PHEX
36 psoriatic arthritis 10.0
37 spondyloarthropathy 9.9
38 hyperostosis 9.9
39 hypophosphatemia 9.9
40 heel spur 9.9
41 tendinitis 9.9
42 periarthritis 9.9
43 patellar tendinitis 9.9
44 bone angioendothelial sarcoma 9.9 MRAP PHB2
45 bile reflux 9.9 MEFV MRAP SERPINI2
46 perineocele 9.9 MEFV MRAP SERPINI2
47 tendinopathy 9.8
48 cystic kidney disease 9.8 MRAP PHB2 SERPINI2
49 synovitis 9.7
50 nail disease 9.7

Comorbidity relations with Enthesopathy via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Enthesopathy:



Diseases related to Enthesopathy

Symptoms & Phenotypes for Enthesopathy

UMLS symptoms related to Enthesopathy:


musculoskeletal symptom, myalgia, joint symptom

MGI Mouse Phenotypes related to Enthesopathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 DMP1 FGF23 MEFV PHB2 PHEX SERPINI2

Drugs & Therapeutics for Enthesopathy

Drugs for Enthesopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4 185243-69-0
2 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
3 Analgesics Phase 4,Phase 3
4 Analgesics, Non-Narcotic Phase 4,Phase 3
5 Anti-Inflammatory Agents Phase 4,Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
7 Antirheumatic Agents Phase 4,Phase 3
8 Gastrointestinal Agents Phase 4
9 Immunosuppressive Agents Phase 4,Phase 3
10
Lidocaine Approved, Vet_approved Phase 2, Phase 3,Phase 1 137-58-6 3676
11
Apremilast Approved, Investigational Phase 3 608141-41-9 11561674
12 Anesthetics Phase 2, Phase 3,Phase 1
13 Anesthetics, Local Phase 2, Phase 3,Phase 1
14 Anti-Arrhythmia Agents Phase 2, Phase 3,Phase 1
15 Central Nervous System Depressants Phase 2, Phase 3,Phase 1
16 Diuretics, Potassium Sparing Phase 2, Phase 3,Phase 1
17 Sodium Channel Blockers Phase 2, Phase 3,Phase 1
18 Angiogenesis Inhibitors Phase 3
19 Angiogenesis Modulating Agents Phase 3
20 Anti-Bacterial Agents Phase 3
21 Anti-Infective Agents Phase 3
22 cadexomer iodine
23
Iodine 7553-56-2 807
24 Hormones
25 Mitogens
26 Performance-Enhancing Substances

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4
2 Treatment for Achilles Tendinopathy Unknown status NCT00835939 Phase 2, Phase 3
3 Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA) Active, not recruiting NCT01307423 Phase 3
4 Effectiveness of Dextrose Injection for Osgood-Schlatter Disease Completed NCT01300754 Phase 1, Phase 2
5 Comparison of the Effect of Radial Shock Wave, Ultrasound-guided Needle Puncture, and Combination of Both in the Treatment of Calcific Tendinitis of the Shoulder Completed NCT02677103
6 Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections Completed NCT01200875
7 Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis Recruiting NCT02962271
8 Distal Erosions and Nail Psoriasis Recruiting NCT02813720
9 Treatment of Acute and Chronic Ligament and Tendon Injuries With Platelet Rich Plasma Recruiting NCT01406821
10 Inflammatory Back Pain and Gluten Free Diet Not yet recruiting NCT03017716

Search NIH Clinical Center for Enthesopathy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: rheumatic diseases

Genetic Tests for Enthesopathy

Anatomical Context for Enthesopathy

MalaCards organs/tissues related to Enthesopathy:

39
Bone, Skin

Publications for Enthesopathy

Articles related to Enthesopathy:

(show top 50) (show all 146)
id Title Authors Year
1
Enthesopathy of the Extensor Carpi Radialis Brevis Origin: Effective Communication Strategies. ( 27077478 )
2016
2
Voriconazole-Induced Periostitis & Enthesopathy in Solid Organ Transplant Patients: Case Reports. ( 27990445 )
2016
3
A Meta-Analysis of the Effect of Corticosteroid Injection for Enthesopathy of the Extensor Carpi Radialis Brevis Origin. ( 27546443 )
2016
4
Detection of subclinical ultrasound enthesopathy and nail disease in patients at risk of psoriatic arthritis. ( 27932277 )
2016
5
Nail involvement can predict enthesopathy in patients with psoriasis. ( 27860304 )
2016
6
Factors associated with operative treatment of enthesopathy of the extensor carpi radialis brevis origin. ( 26995457 )
2016
7
Investigation of Enthesopathy with Ultrasonography and Comparison with Skin Findings in Asymptomatic Psoriatic Patients. ( 27028326 )
2016
8
Controversies in Surgical Management of Recalcitrant Enthesopathy of the Extensor Carpi Radialis Brevis. ( 27491631 )
2016
9
A preliminary study showing that ultrasonography cannot differentiate between psoriatic arthritis and nodal osteoarthritis based on enthesopathy scores. ( 27179103 )
2016
10
A radiological study on intra- and extra-cranial calcifications in adults with X-linked hypophosphatemia and associations with other mineralizing enthesopathies and childhood medical treatment. ( 26913700 )
2016
11
P113. Subclinical Ultrasonographic Enthesopathy and Synovitis in patients with Inflammatory Bowel Disease (IBD) without clinical signs or symptoms of Spondyloarthritis. ( 25717572 )
2015
12
Enthesopathy of the pectoralis major tendon mimicking osteoid osteoma. A case report with an unfortunate series of events. ( 26605199 )
2015
13
Pelvic enthesopathy on CT is significantly more prevalent in patients with diffuse idiopathic skeletal hyperostosis (DISH) compared with matched control patients. ( 26686367 )
2015
14
Conventional Therapy in Adults With XLH Improves Dental Manifestations, But Not Enthesopathy. ( 26439151 )
2015
15
Persistent Pain After Surgery for Enthesopathy of the Extensor Carpi Radialis Brevis Origin. ( 25796379 )
2015
16
Conventional Therapy in Adults With X-Linked Hypophosphatemia: Effects on Enthesopathy and Dental Disease. ( 26176801 )
2015
17
Presence of enthesopathy demonstrated with ultrasonography in systemic sclerosis. ( 25736366 )
2015
18
Treatment of Catastrophic Infection After Surgery for Insertional Achilles Enthesopathy: A Case Report and Review of the Literature. ( 25142918 )
2014
19
Exertional leg pain in familial mediterranean Fever: a manifestation of an underlying enthesopathy and a marker of more severe disease. ( 25223248 )
2014
20
The short-term effect after a single injection of high-molecular-weight hyaluronic acid in patients with enthesopathies (lateral epicondylitis, patellar tendinopathy, insertional Achilles tendinopathy, and plantar fasciitis): a preliminary study. ( 24817495 )
2014
21
Enthesopathy of the lateral cord of the plantar fascia. ( 25154957 )
2014
22
The pisotriquetral joint: osteoarthritis and enthesopathy. ( 24876685 )
2014
23
Metabolic syndrome associated to non-inflammatory Achilles enthesopathy. ( 24535409 )
2014
24
Role of sonography and magnetic resonance imaging in detecting deltoideal acromial enthesopathy: an early finding in the diagnosis of spondyloarthritis and an under-recognized cause of posterior shoulder pain. ( 24658935 )
2014
25
The enthesopathy of celiac patients: effects of gluten-free diet. ( 24567238 )
2014
26
Enthesopathy in patients with familial Mediterranean fever: increased prevalence in M694 V variant. ( 23334425 )
2013
27
Assessment of enthesopathy in patients with fibromyalgia by using new sonographic enthesitis index. ( 24217664 )
2013
28
Poncet's disease: a symmetric seronegative polyarthritis with enthesopathy refractory to the therapy. ( 24149016 )
2013
29
The use of planar bone scintigraphy and HiSPECT for diagnosis of primary and concomitant flexor enthesopathy in the canine elbow. ( 23801368 )
2013
30
The use of the HiSPECT bone scan in canine flexor enthesopathy and coronoid pathology. ( 23375664 )
2013
31
Transcatheter arterial embolization using imipenem/cilastatin sodium for tendinopathy and enthesopathy refractory to nonsurgical management. ( 23707086 )
2013
32
Does enthesopathy relate to M694V gene mutation in patients with Familial Mediterranean fever? ( 23812619 )
2013
33
Arthroscopic features of primary and concomitant flexor enthesopathy in the canine elbow. ( 23708890 )
2013
34
Radiographic features of primary and concomitant flexor enthesopathy in the canine elbow. ( 23094825 )
2013
35
Primary and concomitant flexor enthesopathy of the canine elbow. ( 23801308 )
2013
36
Avulsion fragmentation of the tibial tuberosity apophysis and associated patellar tendon enthesopathy in a skeletally immature dog. ( 23677126 )
2013
37
The occurrence of lower limb enthesopathy in coeliac disease patients without clinical signs of articular involvement. ( 23300330 )
2013
38
COMPUTED TOMOGRAPHY OF CANINE ELBOW JOINTS AFFECTED BY PRIMARY AND CONCOMITANT FLEXOR ENTHESOPATHY. ( 24033837 )
2013
39
Increased enthesopathy in patients with familial Mediterranean fever: evaluation with a new sonographic enthesitis index. ( 23341390 )
2013
40
Autologous blood and platelet-rich plasma injections for enthesopathy of the extensor carpi radialis brevis origin. ( 23455408 )
2013
41
MAGNETIC RESONANCE IMAGING OF PRIMARY AND CONCOMITANT FLEXOR ENTHESOPATHY IN THE CANINE ELBOW. ( 24033814 )
2013
42
Enthesopathy and desmitis of the medial collateral ligament of the cubital joint in 4 horses. ( 23547681 )
2013
43
Ultrasonographic assessment of nail in psoriatic disease shows a link between onychopathy and distal interphalangeal joint extensor tendon enthesopathy. ( 23128597 )
2012
44
Bone scan in enthesopathy involving tendo Achilles. ( 22228344 )
2012
45
Ultrasound revealing subclinical enthesopathy at the greater trochanter level in patients with spondyloarthritis. ( 22015936 )
2012
46
Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. ( 22156725 )
2012
47
The puzzle of generalized osteoarthritis (OA) -- is OA a systemic enthesopathy? ( 22298259 )
2012
48
Lipopolysaccharide treatment suppresses spontaneously developing ankylosing enthesopathy in B10.BR male mice: the potential role of interleukin-10. ( 22721554 )
2012
49
Hand enthesophytes and knee enthesopathy: is osteoarthritis related to a systemic enthesopathy? ( 22753800 )
2012
50
Mineralizing enthesopathy is a common feature of renal phosphate-wasting disorders attributed to FGF23 and is exacerbated by standard therapy in hyp mice. ( 23038738 )
2012

Variations for Enthesopathy

Expression for Enthesopathy

Search GEO for disease gene expression data for Enthesopathy.

Pathways for Enthesopathy

GO Terms for Enthesopathy

Biological processes related to Enthesopathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 biomineral tissue development GO:0031214 9.26 DMP1 PHEX
2 cellular response to vitamin D GO:0071305 9.16 FGF23 PHEX
3 cellular response to parathyroid hormone stimulus GO:0071374 8.96 FGF23 PHEX
4 response to sodium phosphate GO:1904383 8.62 FGF23 PHEX

Sources for Enthesopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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