MCID: ESN007
MIFTS: 61

Eosinophilia malady

Genetic diseases, Blood diseases, Rare diseases categories
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Summaries for Eosinophilia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 0.45 more...

MalaCards: Eosinophilia, also known as disorder characterized by eosinophilia, is related to eosinophilia-myalgia syndrome and pulmonary eosinophilia. An important gene associated with Eosinophilia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are TSLP Signaling Pathway and Apoptosis Pathway. The compounds lte4 and sodium cromoglycate have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and myeloid, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Eosinophilia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

eosinophilia 8 10 45
disorder characterized by eosinophilia 62
eosinophilic leukocytosis 8
eosinophil count raised 8


External Ids:

Disease Ontology8 DOID:999
ICD9CM27 288.3
MeSH35 D004802

Related Diseases for Eosinophilia

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17GeneCards, 18GeneDecks
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Diseases in the Eosinophilia family:

Familial Eosinophilia

Diseases related to Eosinophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 402)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia-myalgia syndrome31.8IL5
2pulmonary eosinophilia31.3EPX, CCR3, CCL11, IL4, IL5, IL8
3asthma31.2CCL11, IL13
4leukemia30.8RNASE3, EPX, CCL11, IFNG, IL4, IL3
5esophagitis30.7CCR3, CCL11, IL5, IL13
6angioedema30.7IL5, RNASE3
7eosinophilic fasciitis30.7IL5
8hypereosinophilic syndrome30.6IL5, IL3, PDGFRB
9strongyloidiasis30.6IL5
10eosinophilic esophagitis30.5CCL11, IL5
11eosinophilic gastroenteritis30.5CCL11, IL5
12churg-strauss syndrome30.4RNASE3, IL5
13filariasis30.4IL13, IL5
14mastocytosis30.4PDGFRB, IL13, IL5
15rhinitis30.4RNASE3, EPX, CCL11, IL4, IL5, IL8
16dermatitis30.3CCL17, CCL11, IFNG, IL4, IL5, IL13
17pneumonia30.3EPX, CCL17, CCL11, IL5, IL8, IL13
18kimura disease30.3RNASE3, IL5
19atopic dermatitis30.2RNASE3, CCL17, CCR3, CCL11, IL4, IL13
20aspergillosis30.2IFNG
21allergic bronchopulmonary aspergillosis30.2IL4, IL5
22conjunctivitis30.2RNASE3
23sinusitis30.2RNASE3, CCL11, IL5
24eosinophilic pneumonia30.2RNASE3, CCL17, CCL11, IL5, IL3, IL13
25bronchitis30.2RNASE3, CCR3, CCL11, IL5, IL8
26chronic eosinophilic pneumonia30.1RNASE3, CCL11, IL5
27omenn syndrome30.1IL4, IL5
28helminthiasis30.1IL13, IL5, RNASE3
29graft versus host disease30.1IFNG, IL4, IL3, IL13
30folliculitis30.1CCL11
31tuberculosis30.0EPX, IFNG, IL4
32acute graft versus host disease30.0IL4, IFNG
33sarcoidosis30.0CCL11, IFNG, IL13
34schistosomiasis30.0RNASE3, IFNG, IL4, IL5, IL13
35onchocerciasis30.0RNASE3, EPX, IL5
36allergic conjunctivitis30.0IL5, IL4, CCL11, RNASE3, IL13
37pulmonary fibrosis30.0PDGFRB, IL13, IL8, CCL17
38allergic rhinitis30.0RNASE3, EPX, CCL17, CCR3, CCL11, IFNG
39mycosis fungoides29.9CCL17, CCR3, IL5
40keratoconjunctivitis29.9RNASE3, CCL11, IL5, IL13
41interstitial lung disease29.9CCL17, CCL11, IL8
42allergic asthma29.9IL4, IL5, IL3, IL8, IL13, RNASE3
43chronic rhinitis29.9RNASE3
44lymphopenia29.9IL4, IFNG
45bullous pemphigoid29.8RNASE3, CCL17, CCL11, IL5, IL13
46bronchiolitis29.8RNASE3, CCL11, IL5, IL8, IL13
47arthritis29.8IFNG, IL4, IL8, IL13, CCR3
48food allergy29.8IL5, IL13, IL4, CCL11, EPX, RNASE3
49malaria29.8IFNG
50paragonimiasis29.8CCL17, IL5

Graphical network of the top 20 diseases related to Eosinophilia:



Diseases related to eosinophilia

Symptoms for Eosinophilia

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Drugs & Therapeutics for Eosinophilia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Eosinophilia

Search NIH Clinical Center for Eosinophilia

Genetic Tests for Eosinophilia

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Anatomical Context for Eosinophilia

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33MalaCards
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MalaCards organs/tissues related to Eosinophilia:

33
Lung, T cells, Myeloid, Bone, Skin, Thyroid, Bone marrow, Liver, Testes, Heart, B cells, Endothelial, Colon, Brain, Monocytes, Lymph node, Salivary gland, Whole blood, Kidney, Nk cells, Eye, Ovary, Breast, Thymus, Skeletal muscle, Spinal cord

Animal Models for Eosinophilia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Eosinophilia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.0PDGFRB, IL13, IL3, IL4, IFNG
2MP:00053818.0IFNG, IL4, IL5, IL13, PDGFRB
3MP:00053887.4CCR3, CCL11, IFNG, IL4, IL5, IL3
4MP:00053847.1CCL17, CCR3, IFNG, IL4, IL3, IL13
5MP:00053767.1CCR3, IFNG, IL4, IL5, IL3, IL13
6MP:00053975.7PDGFRB, EPX, CCL17, CCR3, CCL11, IFNG
7MP:00053875.7CCL11, CCR3, CCL17, EPX, IFNG, IL4

Publications for Eosinophilia

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52PubMed
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Articles related to Eosinophilia:

(show top 50)    (show all 1616)
idTitleAuthorsYear
1
Gene-Gene Interaction Between CCR3 and Eotaxin Genes: The Relationship With Blood Eosinophilia in Asthma. (24404394)
2014
2
Letter: PPI-responsive oesophageal eosinophilia - from initial skepticism to consistent prospective data; authors' reply. (24330242)
2014
3
Angiolymphoid hyperplasia with eosinophilia with follicular mucinosis. (23716828)
2013
4
Increased FDG Uptake of the Bone Marrow Mimicking Malignancy in a Patient of Eosinophilia Secondary to Sparganum mansoni Infection. (23877523)
2013
5
Natural history of severe eosinophilia with uncertain aetiology and proposals on a practical approach to its management. (22151137)
2012
6
Case of angiolymphoid hyperplasia with eosinophilia associated with scabies infestation. (21950730)
2012
7
Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitis. (22134787)
2012
8
The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia. (22190185)
2012
9
IL-5 receptor I+ levels in patients with marked eosinophilia or mastocytosis. (21762978)
2011
10
Peripheral eosinophilia camouflaging anaplastic large cell lymphoma. (18805872)
2011
11
Allopurinol causing drug rash with eosinophilia and systemic symptoms syndrome: a challenging diagnosis. (22162933)
2011
12
Long-term outcomes in pediatric-onset esophageal eosinophilia. (21636117)
2011
13
Cerebrospinal fluid eosinophilia associated with intraventricular shunts. (21492998)
2011
14
Drug-induced lymphadenopathy with eosinophilia and renal failure mimicking lymphoma disease: dramatic onset of DRESS syndrome associated with antibiotic treatment. (21298267)
2011
15
Drug rash, eosinophilia, and systemic symptoms syndrome: Two pediatric cases demonstrating the range of severity in presentation--A case of vancomycin-induced drug hypersensitivity mimicking toxic shock syndrome and a milder case induced by minocycline. (20407399)
2010
16
Angiolymphoid hyperplasia with eosinophilia treated with a novel combination technique of radiofrequency ablation and sclerotherapy. (20100250)
2010
17
Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: effect on eosinophil density and activation in relation to pharmacokinetics. (19432972)
2009
18
The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. (16373672)
2006
19
Angiolymphoid hyperplasia with eosinophilia masquerading as Kimura disease. (15888362)
2005
20
Decreased levels of CXCR3 transcripts in peripheral blood mononuclear cells from patients with atopic dermatitis and with cutaneous diseases associated with eosinophilia. (11480592)
2001
21
The association of skin test reactivity, total serum IgE levels, and peripheral blood eosinophilia with asthma in Kuwait. (11011754)
2000
22
Differential susceptibility of C57BL/6 and DBA/2 mice to ovalbumin-induced pulmonary eosinophilia regulated by Th1/Th2-type cytokines. (10569702)
1999
23
Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. (9034156)
1997
24
Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. (8784786)
1996
25
The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. (8818342)
1996
26
The eosinophilia-myalgia syndrome and the toxic oil syndrome. Pursuing parallels. (8906286)
1996
27
Acute hepatitis, interstitial nephritis, and eosinophilia. (7872595)
1995
28
1,1'-Ethylidenebis[L-tryptophan], an impurity in L-tryptophan associated with eosinophilia-myalgia syndrome, stimulates type I collagen gene expression in human fibroblasts in vitro. (8624499)
1995
29
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
30
P-31 magnetic resonance spectroscopy of skeletal muscle in the eosinophilia-myalgia syndrome: a preliminary study. (8035389)
1994
31
Adrenal function & the pattern of glucocorticoid induced eosinopenia in tropical pulmonary eosinophilia. (8225446)
1993
32
Unusual widespread type of angiolymphoid hyperplasia with eosinophilia mimicking prurigo nodularis. (8277047)
1993
33
The eosinophilia-myalgia syndrome: current concepts and future directions. (1551286)
1992
34
Production of granulocyte-macrophage colony-stimulating factor in two patients with lung cancer, leukocytosis, and eosinophilia. (1540871)
1992
35
Eosinophilia in murine ancylostomiasis. (1512453)
1992
36
Eosinophilia-myalgia syndrome. Natural history in a population-based cohort. (1520057)
1992
37
Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels. The Normative Aging Study. (1928948)
1991
38
Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis. (1918387)
1991
39
Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1929872)
1991
40
Electrocardiographic abnormalities in tropical pulmonary eosinophilia. (2148545)
1990
41
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
42
Elevated serum IgE, eosinophilia, and lung function in rubber workers. (2317085)
1990
43
Frequency, levels, and significance of blood eosinophilia in systemic sclerosis, localized scleroderma, and eosinophilic fasciitis. (3668010)
1987
44
Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization. (6221046)
1982
45
Clinical studies in pulmonary eosinophilia. II--Relation of blood eosinophilia and pulmonary manifestations in clinic patients and urban population. (721166)
1978
46
Adrenaline and tropical pulmonary eosinophilia. (1248889)
1976
47
Drug-induced lung disease: pulmonary eosinophilia and sulphonamides. (1236549)
1975
48
Studies on eosinophilia in parasitic diseases and pellagra. (13755660)
1960
49
The significance of conjunctival eosinophilia in the diagnosis of allergic conjunctivitis. (14896900)
1951
50
Pulmonary eosinophilia (tropical eosinophilia). (18152220)
1949

Variations for Eosinophilia

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Expression for genes affiliated with Eosinophilia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilia

Search GEO for disease gene expression data for Eosinophilia.

Pathways for genes affiliated with Eosinophilia

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Sources:
50PathCards, 38NCBI BioSystems Database, 61Tocris Bioscience, 30KEGG, 54R&D Systems, 5Cell Signaling Technology, 60Thomson Reuters, 12EMD Millipore, 53QIAGEN, 55Reactome
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Pathways related to Eosinophilia according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL8, CCL11
2
Show member pathways
9.5PDGFRB, IL13, IL5
39.3IL3, IL5, IL4
49.2IL13, IL5, IL4
59.2IFNG, IL13
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.1IL4, IFNG
7
Show member pathways
9.1IL8, CCL11, CCR3
89.0IFNG, IL8
9
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.8IL5, IL4, IFNG
108.8IL5, IL4, IFNG
11
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.8IL4, IL5, IL3, IL13
128.8CCL17, CCL11, IL4, IL5
13
Show member pathways
Immune response CD16 signaling in NK cells60
8.8IFNG, IL4, IL3
148.7CCL11, IL4, IL5, IL8
158.7IL8, IL3, IFNG
16
Show member pathways
8.6CCL17, CCR3, CCL11, IL8
17
Show member pathways
8.6CCL17, CCR3, CCL11, IL8
18
Show member pathways
8.6CCL17, CCR3, CCL11, IL8
19
Show member pathways
8.6IL8, CCL11, CCR3, CCL17
208.5IFNG, IL4, IL8
218.4IL13, IL5, IL4, IFNG
22
Show member pathways
8.4IFNG, IL4, IL5, IL13
238.4IFNG, IL4, IL5, IL13
24
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.2CCL11, IFNG, IL4, IL8
25
Show member pathways
8.1IFNG, IL4, IL8, IL13
26
Show member pathways
Type III interferon signaling38
8.0IFNG, IL4, IL5, IL3, IL13
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
7.9IFNG, IL4, IL5, IL3, IL8
287.8IL13, IL8, IL5, IL4, IFNG
297.4IFNG, IL4, IL5, IL3, IL8, IL13
30
Show member pathways
7.1RNASE3, EPX, CCL11, IFNG, IL4, IL5
31
Show member pathways
6.7CCL17, PDGFRB, IL13, IL8, IL3, IL5
32
Show member pathways
6.7IL13, IL8, IL3, IL5, IL4, CCL11
33
Show member pathways
6.7CCL17, CCR3, CCL11, IL4, IL5, IL3
34
Show member pathways
6.3CCL17, CCL11, IFNG, IL4, IL5, IL3
35
Show member pathways
5.9PDGFRB, CCL17, CCR3, CCL11, IFNG, IL4

Compounds for genes affiliated with Eosinophilia

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Eosinophilia according to GeneCards/GeneDecks:

(show top 50)    (show all 164)
idCompoundScoreTop Affiliating Genes
1lte4459.5EPX, CCL11, IL5, RNASE3
2sodium cromoglycate459.5EPX, RNASE3, IL5, CCL11
3pranlukast45 29 1111.2IL5, IL4, RNASE3, CCL11
4ltd4459.0RNASE3, CCR3, IL13, IL3, IL5
5cetirizine45 29 24 1112.0RNASE3, EPX, IL5, IL8, CCL11
6azelastine45 1110.0IL4, RNASE3, IL5, IL3
7roxithromycin45 29 1111.0IL8, CCL11, IL5, CCL17
8ketotifen45 119.9IL5, EPX, RNASE3, CCL11
9praziquantel45 119.9IL4, IL5, IL13, RNASE3
10formoterol45 29 1110.8IL4, IL13, RNASE3, IL8
11ltc4458.8IL5, IL3, EPX, RNASE3, IL13, CCL11
12n-formylmethionyl-leucylphenylalanine458.8CCL11, IL5, IL8, RNASE3, IL3
13nedocromil sodium458.8IL4, RNASE3, IL5, IL8, IL3
14pgd2458.8RNASE3, IL5, EPX, CCR3, IL13, CCL11
15mip 1alpha458.7IL3, IL8, IL13, IL4
16salbutamol45 51 29 24 1112.6EPX, CCL11, IL5, IL13, RNASE3, IL8
17glatiramer acetate45 119.5IL13, IL5, IL4, IFNG
18montelukast45 51 29 1111.4RNASE3, IL4, IL13, IL5, CCL11, IL8
19methacholine45 51 1110.4RNASE3, CCL11, IL4, IL8, IL5, IL13
20prednisolone45 29 1110.3IL13, IL5, IFNG, CCL11, EPX, RNASE3
21leukotriene b445 61 2410.2IL13, IL8, IL3, IL5, EPX, RNASE3
22fmlp458.2IL13, IL8, IL3, RNASE3, CCL11, EPX
23il-12458.1IFNG, IL13, IL8, IL5, IL4
24salmeterol45 51 29 1111.1RNASE3, EPX, CCL11, IL4, IL5, IL8
25ly294002458.0CCL11, IL3, IL5, IL8, IL13, PDGFRB
26ionomycin458.0IL3, IL5, CCL11, IFNG, IL13, IL4
27poly(i-c)457.9IL8, CCL11, IFNG, IL4, IL5, IL3
28gm-csf45 298.8IL5, IL13, IL8, IL4, IFNG, IL3
29hydrocortisone45 3 61 1110.7IL13, IL8, IL3, IL5, IL4, IFNG
30heparin45 29 24 1110.7RNASE3, IL13, EPX, CCR3, IL5, CCL11
31ccl345 298.7IL8, CCR3, CCL11, IFNG, IL13, CCL17
32butyrate457.6CCL11, IL8, IL3, IL5, IFNG, EPX
33genistein45 29 61 3 24 1112.6PDGFRB, IL5, IFNG, CCL11, CCR3, IL3
34fluticasone propionate45 51 61 1110.6RNASE3, CCL11, IFNG, IL4, IL5, IL8
35tacrolimus45 51 119.5IL5, IL13, IFNG, CCL17, IL4, CCL11
36rolipram45 61 299.5IL13, IL8, EPX, CCL11, IFNG, IL4
37herbimycin a45 618.5IL3, CCL11, IL5, IFNG, IL4, IL8
38allergens457.3RNASE3, EPX, CCL17, CCL11, IFNG, IL4
39il 10457.3IL13, IL8, IL3, IL5, IL4, IFNG
40budesonide45 51 119.3IL13, CCL11, EPX, IFNG, IL4, IL8
41actinomycin d457.2CCR3, IL4, IL3, IL8, IFNG, CCL11
42thymidine45 248.2CCR3, CCL11, IFNG, IL4, IL3, IL5
43pge2457.2RNASE3, CCL11, IFNG, IL4, IL5, IL8
44vegf457.1RNASE3, CCL11, PDGFRB, IL13, IL8, IL5
45tarc457.0IL13, CCR3, IFNG, CCL17, CCL11, IL8
46cysteine456.7EPX, CCR3, IL8, IL13, PDGFRB, IL5
47cyclosporin a45 29 618.7IL5, IL8, IL3, IL4, IFNG, CCL11
48histamine45 29 248.5RNASE3, EPX, CCR3, CCL11, IFNG, IL13
49rantes456.3IL8, IL3, IL4, IFNG, CCL11, CCR3
50dexamethasone45 51 29 118.9IL13, IL8, IL3, IL5, IL4, IFNG

GO Terms for genes affiliated with Eosinophilia

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16Gene Ontology
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Cellular components related to Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7IL13, IL4, IFNG
2extracellular regionGO:0055766.5RNASE3, CCL17, CCL11, IFNG, IL5, IL3
3extracellular spaceGO:0056156.5IL13, CCL17, CCL11, IFNG, IL4, IL5

Biological processes related to Eosinophilia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of smooth muscle cell proliferationGO:0486619.8PDGFRB, IL13
2regulation of proton transportGO:0101559.7IL4, IL13
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.6IL4, IL3
4positive regulation of B cell proliferationGO:0308909.5IL13, IL5, IL4
5positive regulation of isotype switching to IgG isotypesGO:0483049.3IL4, IFNG
6positive regulation of MHC class II biosynthetic processGO:0453489.3IL4, IFNG
7positive regulation of chemokine biosynthetic processGO:0450809.3IFNG, IL4
8defense response to protozoanGO:0428329.2IFNG, IL4
9cell-cell signalingGO:0072679.0IL13, IL3, CCL17
10neutrophil chemotaxisGO:0305938.7IL8, IFNG
11cellular component movementGO:0069288.7IL13, IL8, IFNG
12chemotaxisGO:0069358.3CCL17, CCR3, CCL11, IL4, IL8
13inflammatory responseGO:0069548.1CCL17, CCR3, CCL11, IL5, IL8, IL13
14immune responseGO:0069557.7IL13, IL8, IL3, IL5, IL4, CCL11

Molecular functions related to Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.3IL3, IL5, IL4
2chemokine activityGO:0080098.7CCL17, CCL11, IL8
3cytokine activityGO:0051257.9IL13, IL3, IL5, IL4, IFNG

Products for genes affiliated with Eosinophilia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eosinophilia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet