MCID: ESN007
MIFTS: 62

Eosinophilia malady

Genetic diseases, Immune diseases, Blood diseases, Rare diseases categories

Summaries for Eosinophilia

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Wikipedia:65 Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 4.5 more...

MalaCards based summary: Eosinophilia, also known as disorder characterized by eosinophilia, is related to eosinophilia-myalgia syndrome and pulmonary eosinophilia. An important gene associated with Eosinophilia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are TSLP Signaling Pathway and Apoptosis Pathway. The compounds sodium cromoglycate and lte4 have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and myeloid, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Eosinophilia

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 57SNOMED-CT, 29ICD9CM, 35MeSH, 27ICD10
See all sources

Eosinophilia, Aliases & Descriptions:

Name: Eosinophilia 10 12 45
Disorder Characterized by Eosinophilia 62
Eosinophilic Leukocytosis 10
 
Eosinophilic Leucocytosis 62
Eosinophil Count Raised 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology10 DOID:999
ICD9CM29 288.3
MeSH35 D004802
ICD1027 D72.1

Related Diseases for Eosinophilia

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Diseases in the Eosinophilia family:

Eosinophilia, Familial

Diseases related to Eosinophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 419)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia-myalgia syndrome31.7IL5
2pulmonary eosinophilia31.4IL5, IL4, CCL11, EPX, CCR3, IL8
3asthma31.2IL13, CCL11
4leukemia30.9IFNG, RNASE3, EPX, CCL11, IL4, IL3
5esophagitis30.8IL13, CCR3, IL5, CCL11
6angioedema30.7RNASE3, IL5
7eosinophilic fasciitis30.6IL5
8hypereosinophilic syndrome30.6EPX, IL5, PDGFRB, RNASE3, CCL11
9dermatitis30.5CCL17, IL13, RNASE3, IL4
10strongyloidiasis30.5IL5
11rhinitis30.5IL4, CCL11, EPX, RNASE3, IL5, IL8
12pneumonia30.4IL5, IL13, CCL17, CCL11, EPX, IL8
13eosinophilic gastroenteritis30.4IL5, CCL11
14mastocytosis30.4IL5, IL13, PDGFRB
15churg-strauss syndrome30.4IL5, RNASE3
16eosinophilic pneumonia30.4IL13, IL3, IL5, CCL11, CCL17, RNASE3
17filariasis30.4IL5, IL13
18bronchitis30.3RNASE3, IL8, IL5, CCR3, CCL11
19atopic dermatitis30.3CCL17, IL13, IL4, CCR3, RNASE3, CCL11
20kimura disease30.3IL5, RNASE3
21aspergillosis30.2IFNG
22allergic bronchopulmonary aspergillosis30.2IL4, IL5
23sinusitis30.2RNASE3, CCL11, IL5
24omenn syndrome30.2IL4, IL5
25allergic rhinitis30.2IL13, IL8, IL5, IL4, IFNG, CCL11
26allergic asthma30.1IL13, IL8, IL3, RNASE3, EPX, CCL17
27conjunctivitis30.1RNASE3
28pulmonary fibrosis30.1IL8, CCL17, PDGFRB, IL13
29tuberculosis30.1IFNG, IL4, EPX
30chronic eosinophilic pneumonia30.1RNASE3, CCL11, IL5
31schistosomiasis30.1IFNG, IL4, IL5, IL13, RNASE3
32acute graft versus host disease30.0IL4, IFNG
33allergic conjunctivitis30.0IL5, RNASE3, CCL11, IL4, IL13
34folliculitis30.0CCL11
35colitis30.0IFNG, IL4, IL8, IL13
36onchocerciasis30.0RNASE3, EPX, IL5
37mycosis fungoides29.9IL5, CCR3, CCL17
38arthritis29.9IL13, IL8, IL4, IFNG, CCR3
39keratoconjunctivitis29.9RNASE3, CCL11, IL5, IL13
40interstitial lung disease29.9CCL11, CCL17, IL8
41hyper-ige recurrent infection syndrome29.9IFNG, IL4, RNASE3
42uveitis29.9IL4, IFNG, CCL11
43lymphopenia29.9IL4, IFNG
44bullous pemphigoid29.9IL13, RNASE3, CCL11, IL5, CCL17
45bronchiolitis29.9IL5, CCL11, IL8, RNASE3, IL13
46food allergy29.9CCL11, RNASE3, EPX, IL4, IL5, IL13
47vernal keratoconjunctivitis29.8IL13, IL8, IL3, IL5, IL4, CCL11
48chronic rhinitis29.8RNASE3
49rheumatoid arthritis29.7IFNG, IL4, CCL11, CCR3, IL13, RNASE3
50malaria29.7IFNG

Graphical network of the top 20 diseases related to Eosinophilia:



Diseases related to eosinophilia

Symptoms for Eosinophilia

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Drugs & Therapeutics for Eosinophilia

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Drug clinical trials:

Search ClinicalTrials for Eosinophilia

Search NIH Clinical Center for Eosinophilia

Genetic Tests for Eosinophilia

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Anatomical Context for Eosinophilia

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MalaCards organs/tissues related to Eosinophilia:

33
Lung, T cells, Myeloid, Skin, Bone, Thyroid, Bone marrow, Liver, Testes, Heart, B cells, Brain, Colon, Monocytes, Endothelial, Whole blood, Lymph node, Kidney, Salivary gland, Neutrophil, Eye, Thymus, Spinal cord, Skeletal muscle, Breast, Ovary, Prostate, Nk cells, Tongue

Animal Models for Eosinophilia or affiliated genes

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MGI Mouse Phenotypes related to Eosinophilia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.0PDGFRB, IL13, IL3, IL4, IFNG
2MP:00053818.0IFNG, IL4, IL5, IL13, PDGFRB
3MP:00053887.4CCR3, CCL11, IFNG, IL4, IL5, IL3
4MP:00053847.1CCL17, CCR3, IFNG, IL4, IL3, IL13
5MP:00053767.1CCR3, IFNG, IL4, IL5, IL3, IL13
6MP:00053975.7PDGFRB, EPX, CCL17, CCR3, CCL11, IFNG
7MP:00053875.7CCL11, CCR3, CCL17, EPX, IFNG, IL4

Publications for Eosinophilia

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Articles related to Eosinophilia:

(show top 50)    (show all 1691)
idTitleAuthorsYear
1
Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported. (25754017)
2015
2
Eosinophilia induced by clozapine: a report of two cases and review of the literature. (25811003)
2015
3
Acute lymphoblastic leukemia with eosinophilia lacking peripheral blood leukemic cell: a rare entity. (25332543)
2014
4
Gene-Gene Interaction Between CCR3 and Eotaxin Genes: The Relationship With Blood Eosinophilia in Asthma. (24404394)
2014
5
Letter: PPI-responsive oesophageal eosinophilia - from initial skepticism to consistent prospective data; authors' reply. (24330242)
2014
6
Changes in blood eosinophilia during omalizumab therapy as a predictor of asthma exacerbation. (25395927)
2014
7
Angiolymphoid hyperplasia with eosinophilia with follicular mucinosis. (23716828)
2013
8
Increased FDG Uptake of the Bone Marrow Mimicking Malignancy in a Patient of Eosinophilia Secondary to Sparganum mansoni Infection. (23877523)
2013
9
Natural history of severe eosinophilia with uncertain aetiology and proposals on a practical approach to its management. (22151137)
2012
10
Case of angiolymphoid hyperplasia with eosinophilia associated with scabies infestation. (21950730)
2012
11
Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitis. (22134787)
2012
12
The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia. (22190185)
2012
13
IL-5 receptor I+ levels in patients with marked eosinophilia or mastocytosis. (21762978)
2011
14
Peripheral eosinophilia camouflaging anaplastic large cell lymphoma. (18805872)
2011
15
Allopurinol causing drug rash with eosinophilia and systemic symptoms syndrome: a challenging diagnosis. (22162933)
2011
16
Long-term outcomes in pediatric-onset esophageal eosinophilia. (21636117)
2011
17
Cerebrospinal fluid eosinophilia associated with intraventricular shunts. (21492998)
2011
18
Drug-induced lymphadenopathy with eosinophilia and renal failure mimicking lymphoma disease: dramatic onset of DRESS syndrome associated with antibiotic treatment. (21298267)
2011
19
Drug rash, eosinophilia, and systemic symptoms syndrome: Two pediatric cases demonstrating the range of severity in presentation--A case of vancomycin-induced drug hypersensitivity mimicking toxic shock syndrome and a milder case induced by minocycline. (20407399)
2010
20
The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. (16373672)
2006
21
Angiolymphoid hyperplasia with eosinophilia masquerading as Kimura disease. (15888362)
2005
22
Decreased levels of CXCR3 transcripts in peripheral blood mononuclear cells from patients with atopic dermatitis and with cutaneous diseases associated with eosinophilia. (11480592)
2001
23
The association of skin test reactivity, total serum IgE levels, and peripheral blood eosinophilia with asthma in Kuwait. (11011754)
2000
24
Differential susceptibility of C57BL/6 and DBA/2 mice to ovalbumin-induced pulmonary eosinophilia regulated by Th1/Th2-type cytokines. (10569702)
1999
25
Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. (9034156)
1997
26
Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. (8784786)
1996
27
The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. (8818342)
1996
28
The eosinophilia-myalgia syndrome and the toxic oil syndrome. Pursuing parallels. (8906286)
1996
29
1,1'-Ethylidenebis[L-tryptophan], an impurity in L-tryptophan associated with eosinophilia-myalgia syndrome, stimulates type I collagen gene expression in human fibroblasts in vitro. (8624499)
1995
30
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
31
P-31 magnetic resonance spectroscopy of skeletal muscle in the eosinophilia-myalgia syndrome: a preliminary study. (8035389)
1994
32
Adrenal function & the pattern of glucocorticoid induced eosinopenia in tropical pulmonary eosinophilia. (8225446)
1993
33
Unusual widespread type of angiolymphoid hyperplasia with eosinophilia mimicking prurigo nodularis. (8277047)
1993
34
The eosinophilia-myalgia syndrome: current concepts and future directions. (1551286)
1992
35
Production of granulocyte-macrophage colony-stimulating factor in two patients with lung cancer, leukocytosis, and eosinophilia. (1540871)
1992
36
Eosinophilia in murine ancylostomiasis. (1512453)
1992
37
Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels. The Normative Aging Study. (1928948)
1991
38
Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis. (1918387)
1991
39
Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1929872)
1991
40
Electrocardiographic abnormalities in tropical pulmonary eosinophilia. (2148545)
1990
41
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
42
Elevated serum IgE, eosinophilia, and lung function in rubber workers. (2317085)
1990
43
Frequency, levels, and significance of blood eosinophilia in systemic sclerosis, localized scleroderma, and eosinophilic fasciitis. (3668010)
1987
44
Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization. (6221046)
1982
45
Clinical studies in pulmonary eosinophilia. II--Relation of blood eosinophilia and pulmonary manifestations in clinic patients and urban population. (721166)
1978
46
Adrenaline and tropical pulmonary eosinophilia. (1248889)
1976
47
Drug-induced lung disease: pulmonary eosinophilia and sulphonamides. (1236549)
1975
48
Studies on eosinophilia in parasitic diseases and pellagra. (13755660)
1960
49
The significance of conjunctival eosinophilia in the diagnosis of allergic conjunctivitis. (14896900)
1951
50
Pulmonary eosinophilia (tropical eosinophilia). (18152220)
1949

Variations for Eosinophilia

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Expression for genes affiliated with Eosinophilia

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Search GEO for disease gene expression data for Eosinophilia.

Pathways for genes affiliated with Eosinophilia

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Pathways related to Eosinophilia according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL8, CCL11
2
Show member pathways
9.5PDGFRB, IL13, IL5
39.3IL3, IL5, IL4
49.2IL13, IL5, IL4
59.2IFNG, IL13
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.1IL4, IFNG
7
Show member pathways
9.1IL8, CCL11, CCR3
89.0IFNG, IL8
9
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.8IL5, IL4, IFNG
108.8IL5, IL4, IFNG
11
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.8IL4, IL5, IL3, IL13
128.8CCL17, CCL11, IL4, IL5
13
Show member pathways
Immune response CD16 signaling in NK cells60
8.8IFNG, IL4, IL3
148.7CCL11, IL4, IL5, IL8
158.7IL8, IL3, IFNG
16
Show member pathways
8.6CCL17, CCR3, CCL11, IL8
17
Show member pathways
8.6CCL17, CCR3, CCL11, IL8
18
Show member pathways
8.6CCL17, CCR3, CCL11, IL8
19
Show member pathways
8.6IL8, CCL11, CCR3, CCL17
208.5IFNG, IL4, IL8
218.4IL13, IL5, IL4, IFNG
22
Show member pathways
8.4IFNG, IL4, IL5, IL13
238.4IFNG, IL4, IL5, IL13
24
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.2CCL11, IFNG, IL4, IL8
25
Show member pathways
8.1IFNG, IL4, IL8, IL13
26
Show member pathways
Type III interferon signaling38
8.0IFNG, IL4, IL5, IL3, IL13
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
7.9IFNG, IL4, IL5, IL3, IL8
287.8IL13, IL8, IL5, IL4, IFNG
297.4IFNG, IL4, IL5, IL3, IL8, IL13
30
Show member pathways
7.1RNASE3, EPX, CCL11, IFNG, IL4, IL5
31
Show member pathways
6.7CCL17, PDGFRB, IL13, IL8, IL3, IL5
32
Show member pathways
6.7IL13, IL8, IL3, IL5, IL4, CCL11
33
Show member pathways
6.7CCL17, CCR3, CCL11, IL4, IL5, IL3
34
Show member pathways
6.3CCL17, CCL11, IFNG, IL4, IL5, IL3
35
Show member pathways
5.9PDGFRB, CCL17, CCR3, CCL11, IFNG, IL4

Compounds for genes affiliated with Eosinophilia

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Compounds related to Eosinophilia according to GeneCards/GeneDecks:

(show top 50)    (show all 164)
idCompoundScoreTop Affiliating Genes
1sodium cromoglycate459.5RNASE3, CCL11, IL5, EPX
2lte4459.5RNASE3, EPX, CCL11, IL5
3pranlukast45 30 1311.2IL5, IL4, RNASE3, CCL11
4ltd4459.0CCR3, IL5, IL3, IL13, RNASE3
5cetirizine45 30 26 1312.0RNASE3, EPX, CCL11, IL5, IL8
6roxithromycin45 30 1311.0CCL17, CCL11, IL5, IL8
7ketotifen45 139.9RNASE3, IL5, CCL11, EPX
8praziquantel45 139.9RNASE3, IL13, IL5, IL4
9formoterol45 30 1310.8IL13, IL4, IL8, RNASE3
10ltc4458.8IL13, IL3, IL5, CCL11, EPX, RNASE3
11n-formylmethionyl-leucylphenylalanine458.8IL3, IL8, RNASE3, CCL11, IL5
12nedocromil sodium458.8RNASE3, IL4, IL5, IL8, IL3
13pgd2458.8CCL11, IL13, IL5, CCR3, EPX, RNASE3
14mip 1alpha458.7IL3, IL8, IL13, IL4
15salbutamol45 51 30 26 1312.6IL13, RNASE3, EPX, CCL11, IL5, IL8
16glatiramer acetate45 139.5IL13, IL5, IFNG, IL4
17montelukast45 51 30 1311.4RNASE3, CCL11, IL4, IL5, IL8, IL13
18amphotericin b458.4IFNG, IL5, IL13, IL4
19methacholine45 51 1310.4CCL11, IL4, IL13, RNASE3, IL8, IL5
20prednisolone45 30 1310.3IFNG, CCL11, RNASE3, EPX, IL5, IL13
21leukotriene b445 61 2610.2EPX, RNASE3, IL3, CCL11, IL5, IL8
22fmlp458.2IL3, CCL11, IL8, EPX, IL13, IL5
23il-12458.1IL8, IL5, IL4, IFNG, IL13
24salmeterol45 51 30 1311.1RNASE3, IL13, IL8, IL5, IL4, CCL11
25ly294002458.0IL3, PDGFRB, IL13, IL4, CCL11, IL5
26ionomycin458.0IL5, IL4, CCL11, IFNG, IL3, IL13
27poly(i-c)457.9IL4, IL8, IL3, CCL11, IFNG, IL5
28gm-csf45 308.8IL13, IL8, IL3, IL5, IL4, IFNG
29hydrocortisone45 3 61 1310.7IL4, IFNG, IL5, IL13, IL3, IL8
30heparin45 30 26 1310.7CCR3, EPX, CCL11, IL13, IL8, IL5
31ccl345 308.7CCL17, IL8, CCR3, CCL11, IFNG, IL13
32butyrate457.6EPX, IL5, IFNG, CCL11, IL3, IL8
33genistein45 30 61 3 26 1312.6IL5, PDGFRB, IL8, CCL11, CCR3, IFNG
34fluticasone propionate45 51 61 1310.6RNASE3, CCL11, IFNG, IL4, IL5, IL8
35tacrolimus45 51 139.5IL13, IL3, CCL17, CCL11, IFNG, IL4
36rolipram45 61 309.5IL13, IL8, IL5, IL4, IFNG, CCL11
37herbimycin a45 618.5IL5, IL3, IL8, CCL11, CCR3, IL4
38allergens457.4IL4, IL5, IL13, IFNG, CCL11, RNASE3
39il 10457.3IL13, IL8, IL3, IL5, CCL17, IFNG
40budesonide45 51 139.2CCL11, RNASE3, EPX, IFNG, IL4, IL5
41actinomycin d457.2IL13, IL8, IL3, IL4, IFNG, CCR3
42thymidine45 268.2IL4, IL5, IL3, IFNG, CCR3, IL13
43pge2457.2IL13, RNASE3, EPX, IFNG, IL4, IL5
44vegf457.1CCL11, IL4, IL5, IL8, RNASE3, IFNG
45tarc457.0IFNG, CCR3, CCL17, CCL11, IL4, IL5
46cysteine456.7IL13, IL8, IL5, IL4, CCR3, IL3
47cyclosporin a45 30 618.7IL5, CCL11, IL4, CCL17, RNASE3, IL3
48histamine45 30 268.5IL13, IL8, CCL11, IFNG, IL4, IL5
49rantes456.3CCL17, CCL11, IFNG, IL4, IL5, IL3
50dexamethasone45 51 30 138.9CCL17, EPX, RNASE3, CCR3, CCL11, IL8

GO Terms for genes affiliated with Eosinophilia

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Cellular components related to Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.7IL13, IL4, IFNG
2extracellular regionGO:00055766.5RNASE3, CCL17, CCL11, IFNG, IL5, IL3
3extracellular spaceGO:00056156.5IL13, CCL17, CCL11, IFNG, IL4, IL5

Biological processes related to Eosinophilia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of smooth muscle cell proliferationGO:00486619.8PDGFRB, IL13
2regulation of proton transportGO:00101559.7IL4, IL13
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.6IL4, IL3
4positive regulation of B cell proliferationGO:00308909.5IL13, IL5, IL4
5positive regulation of isotype switching to IgG isotypesGO:00483049.3IL4, IFNG
6positive regulation of MHC class II biosynthetic processGO:00453489.3IL4, IFNG
7positive regulation of chemokine biosynthetic processGO:00450809.3IFNG, IL4
8defense response to protozoanGO:00428329.2IFNG, IL4
9cell-cell signalingGO:00072679.0IL13, IL3, CCL17
10neutrophil chemotaxisGO:00305938.7IL8, IFNG
11cellular component movementGO:00069288.7IL13, IL8, IFNG
12chemotaxisGO:00069358.3CCL17, CCR3, CCL11, IL4, IL8
13inflammatory responseGO:00069548.1CCL17, CCR3, CCL11, IL5, IL8, IL13
14immune responseGO:00069557.7IL13, IL8, IL3, IL5, IL4, CCL11

Molecular functions related to Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.3IL3, IL5, IL4
2chemokine activityGO:00080098.7CCL17, CCL11, IL8
3cytokine activityGO:00051257.9IL13, IL3, IL5, IL4, IFNG

Products for genes affiliated with Eosinophilia

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Sources for Eosinophilia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet