Eosinophilia malady

Wikipedia: Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 0.45×109/L⁴⁴ more...

MalaCards: Eosinophilia, also known as disorder characterized by eosinophilia, is related to pulmonary eosinophilia and asthma. An important gene associated with Eosinophilia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are NFAT Signaling and Lymphocyte Interactions and Asthma. The compounds wortmannin and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are cardiovascular system and reproductive system.

Aliases & Descriptions:

eosinophilia 6 7 8 32 43 disorder characterized by eosinophilia 43

eosinophilic leukocytosis 6 eosinophil count raised 6

Diseases related to eosinophilia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 893)

id	Related Disease	Score	Top Affiliating Genes
1	pulmonary eosinophilia	34.5	PDE4A, SFTPD, SERPINA1, IL13, IL3, IL4
2	asthma	34.3	PDE4A, CYSLTR1, RNASE3
3	eosinophilia-myalgia syndrome	33.2	SCXB, SCXA, IL5, IFNG, IDO1, HNMT
4	familial eosinophilia	32.2	IL3, IL5, PRG2
5	hypereosinophilic syndrome	31.5	FIP1L1, IL3, IL5, PDGFRA, PDGFRB, WT1
6	myeloproliferative disorder with eosinophilia	31.2	BCR, IFNA2, PDGFRB
7	allergic rhinitis	31.1	VCAM1, IL13, IL4, IL5, IGES, IGHE
8	angioedema	30.7	SERPINA1, BDKRB2, CD69, IL2, IL5, IGHE
9	kimura disease	30.6	IL13, IL4, IL5, CCL11, CCR3, IGES
10	atopic dermatitis	30.5	PDE4A, SELL, VCAM1, CD69, ITGAM, IL13
11	omenn syndrome	30.0	IL4, IL5, IGHE, IFNG
12	myeloproliferative disorder	30.0	ZMYM2, BCR, CISH, MPO, JAK2, FGFR1
13	eosinophilic pneumonia	29.7	CD69, IL13, IL3, IL5, CCL11, CCL17
14	allergic bronchopulmonary aspergillosis	29.6	SFTPD, IL4, IL5, MBL2, IGES, IGHE
15	allergic asthma	29.5	PDE3B, VCAM1, LGALS9, CISH, CD69, IL13
16	chronic eosinophilic pneumonia	29.5	IL5, CCL11, RNASE3
17	onchocerciasis	29.3	IL13, IL4, IL5, CCL27, CCL11, CCL5
18	eosinophilic fasciitis	29.2	IL5, IFNG, AHR
19	bronchitis	29.0	PDE4A, SELL, BDKRB2, ITGA4, IL17A, MBL2
20	lymphoproliferative syndrome	29.0	IL2, IL2RA, FAS, IGHE, IFNA2
21	peripheral t-cell lymphoma	28.7	IL2RA, IL2RB, ETV6, NOS2, PDGFRA, CXCR3
22	bullous pemphigoid	28.3	IL13, IL5, CCL11, CCL17, CCL5, IGHE
23	ascariasis	28.2	IL5, IL8, IGHE, IDO1, RNASE3, RNASE2
24	b cell deficiency	28.2	IL4, IL5, CCL7, IGHE
25	t-cell leukemia	28.1	ITGA4, IL2, IL2RA, IL2RB, IL3, IL5
26	paragonimiasis	28.1	IL5, CCL17, IGHE, RNASE3, RNASE2, CXCR3
27	adult t-cell leukemia	27.8	BCR, ITGB2, IL2, IL2RA, IL2RB, IL5
28	filariasis	27.8	IL13, IL2, IL4, IL5, IGHE, IFNG
29	eosinophilic gastroenteritis	27.8	IL5, CCL11, IGES, IGHE, ALB, SRF
30	acquired immunodeficiency syndrome	27.8	SFTPD, SERPINA1, CD69, ITGA4, ITGAM, IL2
31	cough variant asthma	27.7	IL4, IL5, IGHE, RNASE3, ACE
32	polyarteritis nodosa	27.7	REN, MPO, IL8, IGES, IFNA2, PRTN3
33	gastroenteritis	27.7	REN, IL1B, IL2, IL5, IL8, CCL11
34	acute myelomonocytic leukemia	27.6	MPO, IL3, CSF1, CSF3, MYH11
35	myelomonocytic leukemia	27.5	MPO, JAK2, IL13, IL3, IL4, ETV6
36	aspergillosis	27.1	SFTPA1, SFTPA2, SFTPD, IL17A, IL1B, IL2RA
37	hepatitis c	27.1	SERPINA1, CISH, CD69, IL2, IL4, FAS
38	acute lymphocytic leukemia	27.1	BCR, MPO, JAK2, IL2, IL3, MAPK8
39	primary biliary cirrhosis	27.1	SELL, IL2RB, MBL2, ALB, PRTN3, GGT1
40	schistosomiasis	27.0	INS, IL13, IL2, IL2RA, IL4, IL5
41	hepatitis	27.0	SERPINA1, IL2RB, FAS, IFNA2, ALB, TGFB1
42	wells syndrome	26.9	IL1B, IL3, IL8, TP63
43	mastocytosis	26.8	CHIC2, MPO, JAK2, CD2, CD69, FIP1L1
44	tuberculosis	26.8	CISH, IL1B, IL4, MBL2, IFNG, NOS2
45	paracoccidioidomycosis	26.6	IL4, IL5, FAS, IFNG, ALB, NOS2
46	immunodeficiency	26.6	SELL, BCR, LGALS9, CISH, CD69, ITGA4
47	wegener's granulomatosis	26.5	SERPINA1, VCAM1, MPO, ITGB2, IL17A, IL2RA
48	pneumothorax	26.5	MUC1, IL3, CCL11, ESR1, ACE
49	multiple sclerosis	26.5	IL1B, IL2RA, IL5RA, MBP, IFNG, ICAM1
50	castleman's disease	26.4	IL5, IL9, ALB, EGFR, CSF3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to eosinophilia:

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MGI Mouse Phenotypes related to eosinophilia:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system phenotype	MP:0005385	INF	SELL, VCAM1, BDKRB2, SCXB, MPO, ITGA4
2	reproductive system phenotype	MP:0005389	INF	PTK2, NOS2, PDGFRA, WT1, ABL2, TYRP1
3	growth/size phenotype	MP:0005378	INF	ACE, MYH11, AHR, TYRP1, THBD,
4	behavior/neurological phenotype	MP:0005386	INF	TGFB3, TYRP1, ACE, ABL2, ABL1, PDGFRA
5	craniofacial phenotype	MP:0005382	INF	, CSF2, CSF1, TYRP1, PDGFRB, PDGFRA
6	tumorigenesis	MP:0002006	INF	SELL, MUC1, JAK2, IL1B, PTK2, NOS2
7	respiratory system phenotype	MP:0005388	INF	CCL24, , TP63, CYSLTR1, CYBA, SRF
8	nervous system phenotype	MP:0003631	INF	TGFB1, THBD, TYRP1, ABL2, ABL1, TGFB3
9	hematopoietic system phenotype	MP:0005397	INF	RAB27A, BDKRB2, LGALS9, ETV6, ,
10	endocrine/exocrine gland phenotype	MP:0005379	10.0	GGT1, WT1, TP63, ETV6, IFNG, IL2RB
11	liver/biliary system phenotype	MP:0005370	9.3	NMU, SOCS3, AHR, ABL1, EGFR, IFNG
12	pigmentation phenotype	MP:0001186	9.2	POMC, TDO2, TYRP1, EGFR, PDGFRA, FAS
13	embryogenesis phenotype	MP:0005380	9.2	PDGFRA, EGFR, ABL1, ABL2, TGFB3, SOCS3
14	renal/urinary system phenotype	MP:0005367	8.5	PDGFRA, PDGFRB, WT1, EGFR, AHR, MYH11
15	normal phenotype	MP:0002873	INF	REN, TP63, HMGCR, ETV6, ALB, IFNG
16	digestive/alimentary phenotype	MP:0005381	INF	MUC1, PDGFRB, EGFR, ABL1, AHR, TGFB1
17	integument phenotype	MP:0010771	INF	IL4, FAS, IFNG, ETV6, TP63, PTK2
18	adipose tissue phenotype	MP:0005375	INF	TGFB1, , SOCS3, CSF2, POMC, NMU
19	immune system phenotype	MP:0005387	INF	PDE4A, ETV6, , TP63, , PTK2
20	cellular phenotype	MP:0005384	INF	PTK2, TDO2, , CXCR3, SOCS3, CSF1
21	mortality/aging	MP:0010768	INF	EGFR, MYH11, GGT1, C5AR1, ABL1, ABL2
22	muscle phenotype	MP:0005369	INF	NOS2, PDGFRA, PDGFRB, WT1, EGFR, ABL1
23	vision/eye phenotype	MP:0005391	INF	AHR, TYRP1, TGFB1, TGFB3, TDO2,
24	homeostasis/metabolism phenotype	MP:0005376	INF	IL25, ALB, ETV6, ESR1, , TP63
25	no phenotypic analysis	MP:0003012	INF	VCAM1, LGALS9, POMC, AHR, EGFR, SRF
26	other phenotype	MP:0005395	INF	CSF2, CSF1, CXCR3, , PDGFRA, NOS2
27	skeleton phenotype	MP:0005390	INF	TYRP1, ABL1, EGFR, SRF, PTGS2, TGFB3

Articles related to eosinophilia:

(show top 50)    (show all 278)

id	Title	Authors	Year	Affiliating Genes
1	AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-synd rome and toxic oil syndrome? (19941898)	Rieber N.... Belohradsky B.H.	2010	AHR
2	A diagnostically difficult case of chronic myeloid ne oplasm with eosinophilia and abnormalities of PDGFRA effectively treated with i matinib in accelerated phase: case report. (20010473)	Rodzaj M.... ZduA8czyk A.	2009	PDGFRA, FIP1L1
3	Five years since the discovery of FIP1L1-PDGFRA: what we have learned about the fusion and other molecularly defined eosinophilias. (18843283)	Gotlib J.... Cools J.	2008	JAK2, ETV6
4	T helper cell population and eosinophilia in nasal polyps. (17982921)	Cheng W.... Shi G.	2007	IL4
5	WT1 transcript amount discriminates secondary or reactive eosinophilia from idiopathic hypereosinophilic syndrome or chronic eosinophilic leukemia. (17508006)	Cilloni D.... Saglio G.	2007	WT1
6	Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome. (17266055)	Kim Y.J.... Klion A.D.	2007	IGHE
7	IL-25 regulates the expression of adhesion molecules on eosinophils: mechanism of eosinophilia in allergic inflammation. (16792588)	Cheung P.F.... Lam C.W.	2006	ICAM1, MAPK8, MAPK14
8	Regulatory mechanisms of galectin-9 and eotaxin-3 synthesis in epidermal keratinocytes: possible involvement of galectin-9 in dermal eosinophilia of Th1-polarized skin inflammation. (17073866)	Igawa K.... Yokozeki H.	2006	IL4, CCL11, CCL26
9	Vascular endothelial growth factor is involved in angioedema associated with eosinophilia. (16422174)	Harada M.... Sata M.	2005	IL5
10	Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia. (16014847)	Kim Y.J.... Nutman T.B.	2005	RNASE2, RNASE3
11	Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E. (15213147)	Fitzsimmons C.M.... Dunne D.W.	2004	IL5
12	Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases. (15534922)	Ustun S.... Ertabaklar H.	2004	IL5
13	Primary cutaneous CD30 anaplastic large cell lymphoma with keratoacanthoma-like pseudocarcinomatous hyperplasia and marked eosinophilia and neutrophilia. (15186435)	Lin J.H.... Lee J.Y.	2004	MUC1
14	p63 expression in sclerosing mucoepidermoid carcinomas with eosinophilia arising in the thyroid. (15001991)	Hunt J.L.... Barnes E.L.	2004	TP63
15	Eotaxin expression in oral squamous cell carcinomas with and without tumour associated tissue eosinophilia. (14629326)	Lorena S.C.... Kowalski L.P.	2003	CCL11
16	Smoking and atopy as determinants of sputum eosinophilia and bronchial hyper-responsiveness in adults with normal lung function. (12924523)	PetAoys T.... Haahtela T.	2003	MPO, RNASE3
17	Relationship between the eosinophilia of bronchoalveolar lavage fluid (BALF) and the severity of pulmonary fibrosis induced by bleomycin in rats. (12843618)	Cui T.... Nishioka Y.	2003	HGF, TGFB1
18	Immediate-Type allergy against human insulin associat ed with marked eosinophilia in type 2 diabetic patient. (11523901)	Nagai Y.... Nomura G.	2001	INS
19	Eosinophilia, interleukin-5, and tumour necrosis factor-alpha in asthmatic children. (11350304)	Hughes J.M.... Armour C.L.	2001	IL5, RNASE3
20	Pathogenic roles of eosinophils in guinea-pig contact sensitivity: regulation of dermal eosinophilia with remotely administered IL-5. (11122232)	Satoh T.... Nishioka K.	2000	IL5
21	Granulocyte-macrophage colony-stimulating factor and interleukin-5 concentrations in premature neonates with eosinophilia. (10802841)	Calhoun D.A.... Christensen R.D.	2000	CSF2, IL5
22	Eosinophilia with aberrant T cells and elevated serum levels of interleukin-2 and interleukin-15. (10824075)	Means-Markwell M.... Lucey D.	2000	IL2
23	The association of skin test reactivity, total serum IgE levels, and peripheral blood eosinophilia with asthma in Kuwait. (11011754)	Khadadah M.... Sugathan T.N.	2000	IGHE, IGES
24	Eotaxin contributes to renal interstitial eosinophilia. (10052481)	Wada T.... Yokoyama H.	1999	CCL11, CHIA
25	Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia. (10511609)	Simon H.U.... Blaser K.	1999	IL5
26	The relationship of skin test positivity, high serum total IgE levels, and peripheral blood eosinophilia to symptomatic and asymptomatic airway hyperresponsiveness. (10051274)	Jansen D.F.... Postma D.S.	1999	IGHE
27	IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. (10427975)	Dong Q.... Nicolaides N.C.	1999	IL9
28	Eosinophilia in Wegener's granulomatosis. (10559120)	Potter M.B.... Finger D.R.	1999	PRTN3
29	Dissociation of airway hyperresponsiveness from immunoglobulin E and airway eosinophilia in a murine model of allergic asthma. (10340953)	Wilder J.A.... Lipscomb M.F.	1999	IGHE
30	A case of episodic angioedema associated with blood eosinophilia: upregulated C5a receptor expression on eosinophils. (9542615)	Nakashima K.... Abe M.	1998	C5AR1
31	Kimura's disease and angiolymphoid hyperplasia with eosinophilia-- on disease with different expressions? (10909631)	Lichter H.... Feinmesser R.	1998	IGHE
32	Eosinophilia and interleukin-5: role in pulmonary atopic processes (10410362)	Druilhe A.... Pretolani M.	1998	IL5
33	Cellular localization of interleukin-5 expression in rectal carcinoma with eosinophilia. (9744323)	Tajima K.... Sasaki H.	1998	MBP
34	Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. (9034156)	Rothenberg M.E.... Leder P.	1997	CCL11
35	Peripheral and nasal eosinophilia and serum total immunoglobulin E levels in children with ascariasis. (8993177)	YazicioA9lu M.... YalAsin I.	1996	IGHE
36	Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. (8784786)	Rothenberg M.E.... Luster A.D.	1996	CCL11, IL5
37	Serum concentrations of interleukin-5 and the production of lymphocytes in reactive eosinophilia. (7549513)	Koike T.... Saitou K.	1995	IL5
38	A case of tropical eosinophilia associated with pleural effusion (7791276)	Oyamada Y.... Yamasawa F.	1995	IGHE
39	Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin-5. (7613159)	Egan R.W.... Bodmer M.W.	1995	IL5
40	Estrogen receptors and the response to sex hormones i n angiolymphoid hyperplasia with eosinophilia. (1599273)	Moy R.L.... Amenta J.S.	1992	ESR1
41	Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. (1560199)	Durham S.R.... Hamid Q.A.	1992	IL3, IL4, IL5
42	Eosinophilia and cellular cytokine responsiveness in hemodialysis patients. (1477320)	Hertel J.... Bosch J.P.	1992	IL2
43	Correlation of eosinophilia with clinical response in patients with advanced carcinoma treated with low-dose recombinant interleukin-2 and mitomycin C. (1511459)	Arinaga S.... Akiyoshi T.	1992	IL2
44	Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis. (1918387)	Limaye A.P.... Nutman T.B.	1991	IL5
45	Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels. The Normative Aging Study. (1928948)	Tollerud D.J.... Weiss S.T.	1991	IGHE
46	Role of IL-5 in IL-2-induced eosinophilia. In vivo and in vitro expression of IL-5 mRNA by IL-2. (2373861)	Yamaguchi Y.... Kasahara T.	1990	IL2, IL5
47	The BALB/c mouse as a model for immunological studies of microfilariae-induced pulmonary eosinophilia. (2382764)	Egwang T.G.... Kazura J.W.	1990	IGHE
48	Pulmonary infiltration with eosinophilia possibly in duced by cefotiam in a case of steroid-dependent asthma (2273665)	Irie M.... Nakagawa T.	1990	IGHE
49	Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients. (2193099)	Limaye A.P.... Nutman T.B.	1990	IL3, IL5, CSF1
50	Detection of interleukin-5 messenger RNA in Reed-Sternberg cells of Hodgkin's disease with eosinophilia. (2403816)	Samoszuk M.... Nansen L.	1990	IL5

Genes related to eosinophilia according to GeneCards:

(show top 50)    (show all 125)

id	Symbol	Description	Score	GeneCards Section Context
1	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.1	Publications, Summaries
2	EOS	eosinophilia, familial	11.0	Aliases & Descriptions
3	ACSL6	acyl-CoA synthetase long-chain family member 6	11.0	Summaries
4	PDE4DIP	phosphodiesterase 4D interacting protein	11.0	Summaries, Publications
5	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
6	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
7	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
8	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
9	EPX	eosinophil peroxidase	11.0	Publications
10	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
11	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
12	CCR3	chemokine (C-C motif) receptor 3	11.0	Publications
13	PDE4A	phosphodiesterase 4A, cAMP-specific	11.0	Publications
14	IL4	interleukin 4	11.0	Publications
15	IL13	interleukin 13	11.0	Publications
16	IFNG	interferon, gamma	11.0	Publications
17	IL8	interleukin 8	11.0	Publications
18	CCL7	chemokine (C-C motif) ligand 7	11.0	Publications
19	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
20	CYSLTR1	cysteinyl leukotriene receptor 1	11.0	Publications
21	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
22	SFTPD	surfactant protein D	11.0
23	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
24	GGT1	gamma-glutamyltransferase 1	11.0	Publications
25	ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	11.0
26	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
27	IFNA2	interferon, alpha 2	11.0	Publications
28	SCXA	scleraxis homolog A (mouse)	11.0
29	RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	11.0	Publications
30	CCL24	chemokine (C-C motif) ligand 24	11.0	Publications
31	IGES	immunoglobulin E concentration, serum	11.0	Publications
32	LGALS9	lectin, galactoside-binding, soluble, 9	11.0	Publications
33	CCL13	chemokine (C-C motif) ligand 13	11.0	Publications
34	CCL27	chemokine (C-C motif) ligand 27	11.0	Publications
35	CD2	CD2 molecule	11.0	Publications
36	HNMT	histamine N-methyltransferase	11.0	Publications
37	IL9	interleukin 9	11.0	Publications
38	CCL26	chemokine (C-C motif) ligand 26	11.0	Publications
39	FIP1L1	FIP1 like 1 (S. cerevisiae)	11.0	Publications
40	TYRP1	tyrosinase-related protein 1	11.0
41	CD69	CD69 molecule	11.0	Publications
42	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
43	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
44	IL5RA	interleukin 5 receptor, alpha	11.0	Publications
45	C5AR1	complement component 5a receptor 1	11.0	Publications
46	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	11.0	Publications
47	PRTN3	proteinase 3	11.0	Publications
48	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
49	IDO1	indoleamine 2,3-dioxygenase 1	11.0	Publications
50	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications

Pathways related to eosinophilia according to GeneDecks:

(show top 50)    (show all 194)

id	Pathway	Score	Top Affiliating Genes
1	NFAT Signaling and Lymphocyte Interactions36	10.7	CD2, CD3D, IL13, IL2, IL2RB, IL3
2	Asthma20	10.7	IL13, IL3, IL4, IL5, IL9, CCL11
3	JNK Pathway36	10.6	CD2, FGFR1, IL2, IL2RA, IL2RB, IL3
4	Cytokine Network36	10.4	IL13, IL1B, IL2, IL3, IL4, IL5
5	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.3	CD3D, IL2, IL2RA, IL2RB, CCL3, CSF2
6	Regulation of eIF4 and p70S6K36	10.2	CD2, ITGA1, ITGA4, ITGAM, ITGB2, IL13
7	RAR-Gamma-RXR-Alpha Degradation36	10.1	CD2, IL2, IL3, IL9, MAPK14, CCL7
8	PGC1Alpha Pathway36	10.1	CD2, IL13, IL1B, IL2, IL2RB, IL3
9	Akt Signaling36	9.8	PDE3B, CD2, ITGA1, ITGAM, ITGB2, FGFR1
10	Hematopoietic cell lineage20	9.7	CD2, CD3D, ITGA1, ITGA4, ITGAM, IL1B
11	Transendothelial Migration of Leukocytes36	9.6	VCAM1, ITGA1, ITGA4, ITGAM, ITGB2, IL8
12	Rheumatoid arthritis20	9.6	ITGB2, IL17A, IL1B, IL8, CCL3, CCL5
13	Glioma Invasiveness36	9.6	ITGA1, ITGA4, ITGAM, ITGB2, IL3, IL9
14	Paxillin Interactions36	9.6	ITGA1, ITGA4, ITGAM, ITGB2, FGFR1, IL3
15	Immune response Role of integrins in NK cells cytotoxicity10	9.5	VCAM1, ITGA4, ITGAM, ITGB2, IL8, MAPK14
16	Chemokine Signaling36	9.5	JAK2, IL8, MAPK8, MAPK14, MAPK1, CCL7
17	Immune response_Role of integrins in NK cells cytotoxicity41	9.5	VCAM1, ITGA4, ITGAM, ITGB2, IL8, MAPK14
18	Glucocorticoid Receptor Signaling36	9.4	CD2, IL13, IL1B, IL2, IL2RA, IL2RB
19	PEDF Induced Signaling36	9.3	CD2, IL13, IL1B, IL2, IL3, IL4
20	PPAR Pathway36	9.3	ITGA1, ITGA4, ITGAM, ITGB2, FGFR1, IL2
21	Endothelin-1 Signaling Pathway36	9.2	CD2, IL13, IL1B, IL2, IL3, IL4
22	PTEN Pathway36	9.1	ITGA1, ITGA4, ITGAM, ITGB2, FGFR1, IL2
23	all-trans-Retinoic Acid Signaling in Brain36	8.9	CD2, IL13, IL1B, IL2, IL3, IL4
24	PAK Pathway36	8.9	CD2, FGFR1, IL13, IL1B, IL2, IL2RA
25	Rac1 Pathway36	8.9	ITGA1, ITGA4, ITGAM, ITGB2, FGFR1, IL2
26	p38 Signaling36	8.8	CD2, CD3D, FGFR1, IL13, IL1B, IL2
27	Malaria20	8.8	VCAM1, ITGB2, IL1B, IL8, IFNG, ICAM1
28	Molecular Mechanisms of Cancer36	8.8	CD2, ITGA1, ITGA4, ITGAM, ITGB2, FGFR1
29	MAPK Family Pathway36	8.7	CD2, FGFR1, IL13, IL1B, IL2, IL2RA
30	Cytokine-cytokine receptor interaction20	8.7	IL13, IL17A, IL1B, IL2, IL25, IL2RA
31	TGF-Beta Pathway36	8.7	CD2, FGFR1, IL13, IL1B, IL2, IL2RA
32	Rho Family GTPases36	8.6	CD2, ITGA1, ITGA4, ITGAM, ITGB2, FGFR1
33	MIF Mediated Glucocorticoid Regulation36	8.5	CD2, IL13, IL1B, IL2, IL3, IL4
34	Antioxidant Action of Vitamin-C36	8.5	JAK2, CD2, FGFR1, IL13, IL1B, IL2
35	p70S6K Signaling36	8.4	JAK2, INS, FGFR1, IL2, IL2RA, IL3
36	MIF Regulation of Innate Immune Cells36	8.3	CD2, IL13, IL1B, IL2, IL3, IL4
37	ERK Signaling36	8.3	CD2, CD3D, ITGA1, ITGA4, ITGAM, ITGB2
38	Leishmaniasis20	8.2	JAK2, ITGA4, ITGAM, ITGB2, IL1B, IL4
39	Chagas disease (American trypanosomiasis)20	8.1	BDKRB2, CD3D, IL1B, FAS, MAPK8, MAPK14
40	Jak-STAT signaling pathway20	INF	CISH, JAK2, IL13, IL2, IL2RA, IL2RB
41	MAPK Signaling36	INF	ITGA1, ITGA4, ITGAM, ITGB2, FGFR1, IL1B
42	IL-6 Pathway36	INF	CD2, IL3, IL4, IL5, IL8, IL9
43	JAK-STAT Pathway36	INF	JAK2, CD2, FGFR1, IL13, IL1B, IL2
44	Tec Kinases Signaling36	INF	JAK2, CD2, CD3D, ITGA1, ITGA4, ITGAM
45	Chemokine signaling pathway20	INF	JAK2, IL8, MAPK1, CCL7, CCL26, CCL27
46	Signaling Involved in Cardiac Hypertrophy36	INF	JAK2, ITGA1, ITGA4, ITGAM, ITGB2, FGFR1
47	SOCS Pathway36	INF	CISH, JAK2, CD2, INS, IL13, IL1B
48	Renin-Angiotensin Pathway36	INF	REN, VCAM1, JAK2, FGFR1, IL2, IL2RA
49	STAT3 Pathway36	INF	JAK2, CD2, IL13, IL1B, IL2, IL2RA
50	Measles20	INF	JAK2, CD3D, IL13, IL1B, IL2, IL2RA

Compounds related to eosinophilia according to GeneDecks:

(show top 50)    (show all 448)

id	Compound	Score	Top Affiliating Genes
1	wortmannin32 42	INF	PDE3B, PDE4A, VCAM1, JAK2, CD2, ITGA1
2	ionomycin32	10.9	CD2, CD69, IL3, IL5, IL9, CCL11
3	salmeterol32 42 9 9	13.8	PDE4A, ITGB2, IL13, IL2, IL4, IL5
4	allergens32	10.8	SFTPD, CD69, IL13, IL4, IL5, IL9
5	ltc432	10.8	ITGB2, IL13, IL3, IL5, CCL11, CYSLTR1
6	glucose32	10.7	PDE4A, RAB27A, CISH, CD2, FGFR1, IFNA2
7	montelukast32 34 9 9	13.4	ITGAM, IL13, IL2RA, IL4, IL5, IL8
8	con a32	10.4	CD2, CD69, ITGB2, IL2, IL2RA, IL2RB
9	agar32	10.3	MUC1, JAK2, FGFR1, IL9, ETV6, PDGFRB
10	hyaluronic acid32 18	11.2	MUC1, ITGB2, IL13, RNASE3, WT1, THBD
11	tarc32	10.1	ITGA4, IL13, IL4, IL5, IL8, IL9
12	poly(i-c)32	10.1	VCAM1, CD69, IL1B, IL3, IL4, IL5
13	il 1032	9.9	IL13, IL1B, IL2, IL2RA, IL2RB, IL3
14	leukotriene b432 42 18	11.9	PDE4A, SELL, MPO, ITGAM, ITGB2, IL13
15	pgd232	9.9	ITGAM, IL13, IL5, CCL11, CCR3, PTGS2
16	isoproterenol32 9 9	11.8	PDE3B, PDE4A, SELL, ITGAM, IL13, IL3
17	gm-csf32	9.8	IL13, IL1B, IL2, IL3, IL4, IL5
18	infliximab32 9 9	11.6	ITGA4, IL17A, IL1B, IL2RA, IL2RB, IL4
19	methacholine32 9 9	11.6	PDE3B, REN, MPO, ITGA4, IL13, IL17A
20	pentoxifylline32 9 9	11.5	PDE3B, PDE4A, SELL, VCAM1, MPO, ITGA4
21	endotoxin32	9.5	SFTPD, SELL, SAA4, JAK2, ITGAM, ITGB2
22	n-formylmethionyl-leucylphenylalanine32	9.4	SELL, MPO, ITGAM, ITGB2, IL3, MAPK14
23	calcitriol32 42 9 18 9	13.4	REN, ITGAM, IL13, IL2, IL2RA, IL3
24	12-o-tetradecanoylphorbol 13-acetate32	9.2	JAK2, ITGAM, ITGB2, FGFR1, IL2RB, IL3
25	ccl332	9.2	IL13, IL1B, IL8, CCL7, CCL26, CCL27
26	butyrate32	9.0	MUC1, MPO, JAK2, ITGA4, ITGB2, IL3
27	hydrocortisone32 9 9	10.8	REN, MUC1, INS, IL13, IL1B, IL2
28	thyroxine32 18	9.8	REN, INS, IL13, IL2RB, IL4, IL5
29	prednisolone32 9 9	10.4	SFTPD, SELL, VCAM1, MPO, ITGAM, ITGB2
30	lactate32	8.2	SFTPD, SELL, VCAM1, MPO, ITGAM, ITGB2
31	adenylate32	8.1	PDE3B, PDE4A, VCAM1, BDKRB2, ITGAM, ITGB2
32	calcium32 9 18 9	9.9	PDE3B, PDE4A, REN, SFTPA1, SFTPA2, SFTPD
33	herbimycin a32 42	7.5	SELL, VCAM1, JAK2, CD69, ITGB2, IL1B
34	nitric oxide32 9 18 9	8.3	PDE3B, PDE4A, REN, SFTPD, SERPINA1, VCAM1
35	pd 98,05932	INF	PDE4A, VCAM1, BDKRB2, BCR, JAK2, CD69
36	superoxide32 18	INF	PDE3B, PDE4A, SELL, VCAM1, LCP1, MPO
37	genistein32 9 18 9	INF	SELL, VCAM1, BDKRB2, BCR, JAK2, CD69
38	sb 20358032 42	INF	VCAM1, ITGAM, ITGB2, FGFR1, IL13, IL17A
39	n acetylcysteine32	INF	VCAM1, JAK2, ITGAM, IL2RA, IL2RB, IL3
40	paraffin32	INF	SELL, SERPINA1, VCAM1, MUC1, MPO, IL2RA
41	ifn-alpha32	INF	CISH, IL13, IL17A, IL2, IL2RA, IL2RB
42	actinomycin d32	INF	PDE4A, MUC1, JAK2, CD69, IL13, IL17A
43	thalidomide32 42 9 9	INF	PDE4A, SELL, ITGB2, IL1B, IL2, IL5
44	ribavirin32 34 9 9	INF	IL2, IL3, IL4, MBL2, CCL3, IFNA2
45	5fluorouracil32	INF	MUC1, MPO, IL2, IL2RA, IL3, FAS
46	cholesterol32 9 18 9	INF	PDE3B, REN, SFTPD, SERPINA1, VCAM1, BCR
47	matrigel32	INF	VCAM1, MUC1, JAK2, ITGA1, ITGA4, IL8
48	retinoic acid32 42 18	INF	PDE4A, SELL, VCAM1, MUC1, MPO, JAK2
49	oxygen32 18	INF	SFTPD, SERPINA1, BCR, MPO, JAK2, CD69
50	lipid32	INF	PDE3B, PDE4A, SFTPD, SERPINA1, VCAM1, BDKRB2

Cellular components related to eosinophilia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	INF	TGFB3, THBD, ACSL6, ACE, EGFR, PDGFRB
2	integral to plasma membrane	GO:005887	9.3	CYSLTR1, PDGFRA, PDGFRB, THBD, TACR1, CXCR3
3	platelet alpha granule lumen	GO:031093	9.2	HGF, KNG1, TGFB3, TGFB1, ALB, SERPINA1
4	external side of plasma membrane	GO:009897	8.9	IL4, FAS, IFNG, ICAM1, ACE, CXCR3
5	extracellular region	GO:005576	7.4	CRH, ALB, IFNG, IFNA2, CCL5, CCL3
6	extracellular space	GO:005615	5.8	HGF, ICAM1, IFNG, IFNA2, CCL5, CCL13
7	cytosol	GO:005829	INF	MAPK1, CCL3, IDO1, , PTK2, NOS2

Biological processes related to eosinophilia according to GeneDecks:

(show top 50)    (show all 62)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	, TP63, SRF, TGFB1, TGFB3,
2	eosinophil chemotaxis	GO:048245	10.9	CCL5, CCL13, CCL24, CCL3, CCR3, CCL11
3	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.8	CSF2, IL4, IL3, IL2, JAK2
4	cellular calcium ion homeostasis	GO:006874	10.6	TGFB1, CCL5, CCL13, CCL3, CCL11, CCL7
5	respiratory gaseous exchange	GO:007585	10.6	CYSLTR1, HNMT, SFTPD, SFTPA2, SFTPA1
6	positive regulation of osteoclast differentiation	GO:045672	10.5	CSF1, IFNG, CCL5, IL17A
7	leukocyte cell-cell adhesion	GO:007159	10.5	ICAM1, CCL5, ITGB2, ITGA4, VCAM1
8	regulation of cell shape	GO:008360	10.4	PTK2, ITGB2, CCL7, CCL11, CCL3, CCL24
9	cellular response to interleukin-1	GO:071347	10.4	ICAM1, CCL5, CCL3, IL8, IL17A
10	positive regulation of gene expression	GO:010628	10.4	CSF2, CSF1, TGFB1, CCL5, CCL3, MAPK8
11	peptidyl-tyrosine phosphorylation	GO:018108	10.4	ABL2, ABL1, PDGFRB, PDGFRA, PTK2, FGFR1
12	positive regulation of natural killer cell chemotaxis	GO:2000503	10.4	CCL5, CCL3, CCL7
13	neutrophil chemotaxis	GO:030593	10.3	C5AR1, IFNG, CCL3, IL8, IL1B, ITGB2
14	regulation of immune response	GO:050776	10.3	VCAM1, CD3D, ITGA4, ITGB2, IL4, ICAM1
15	calcium-mediated signaling	GO:019722	10.2	IL8, CCL3, CXCR3, NMUR1, NMUR2
16	leukocyte migration	GO:050900	10.2	THBD, ICAM1, GRB7, ITGB2, ITGAM, ITGA4
17	regulation of cell adhesion	GO:030155	10.2	ABL2, ABL1, SRF, ICAM1, IL8
18	immune response	GO:006955	10.2	CCL17, CCL24, CCL13, IGHE, PRG2, CSF2
19	chemotaxis	GO:006935	10.0	CCL7, CCL26, CCL27, CCL11, CCL17, CCR3
20	positive regulation of interleukin-23 production	GO:032747	10.0	CSF2, IFNG, IL17A
21	lipopolysaccharide-mediated signaling pathway	GO:031663	10.0	TGFB1, CCL5, CCL3, MAPK14, IL1B
22	positive regulation of T cell proliferation	GO:042102	10.0	IFNG, CCL5, IL4, IL1B, VCAM1
23	positive regulation of DNA replication	GO:045740	9.9	CSF2, TGFB3, EGFR, PDGFRA, IL3, INS
24	elevation of cytosolic calcium ion concentration	GO:007204	9.9	C5AR1, KNG1, NMUR2, CXCR3, TACR1, PDGFRA
25	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.9	HGF, PDGFRB, PDGFRA, PTK2, CCL5, FGFR1
26	aging	GO:007568	9.8	SOCS3, TGFB3, TGFB1, HMGCR, CCL5, FAS
27	cell surface receptor signaling pathway	GO:007166	9.7	EGFR, IFNG, IFNA2, MAPK14, IL2RA, CD3D
28	response to hypoxia	GO:001666	9.5	SOCS3, TGFB3, TGFB1, NOS2, SRF, FAS
29	cell-cell signaling	GO:007267	9.4	CCL17, CCL3, CCL24, CCL13, CCL5, IFNA2
30	response to lipopolysaccharide	GO:032496	9.4	SOCS3, THBD, PTGS2, IDO1, FAS, IL13
31	activation of MAPK activity	GO:000187	9.1	HGF, C5AR1, TGFB3, MAPK1, MAPK14, IL1B
32	MAPK cascade	GO:000165	9.1	TGFB1, EGFR, CCL5, CCL3, MAPK1, IL1B
33	inflammatory response	GO:006954	9.0	BDKRB2, CCL17, CCR3, CCL3, CCL24, CCL13
34	response to stress	GO:006950	8.9	NMU, AHR, EGFR, MAPK1, MAPK14, MAPK8
35	platelet activation	GO:030168	8.6	HGF, KNG1, TGFB3, TGFB1, SRF, PTK2
36	negative regulation of apoptotic process	GO:043066	8.6	CSF2, EGFR, WT1, PTK2, ALB, MAPK8
37	positive regulation of nitric oxide biosynthetic process	GO:045429	8.2	EGFR, PTGS2, ESR1, ICAM1, IFNG, IL1B
38	apoptotic process	GO:006915	7.9	MAPK1, IFNG, TP63, PTK2, ABL1, AHR
39	response to estradiol stimulus	GO:032355	INF	SOCS3, , TGFB1, AHR, PTGS2, ESR1
40	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	INF	SOCS3, , MAPK1, JAK2, CISH
41	cellular component movement	GO:006928	INF	CXCR3, , PTGS2, IFNG, MAPK14, IL8
42	acute-phase response	GO:006953	INF	SERPINA1, SAA4, INS, MBL2,
43	blood coagulation	GO:007596	INF	ALB, , PTK2, NOS2, ABL1, THBD
44	positive regulation of cell migration	GO:030335	INF	CCL3, CCL24, CCL5, PTK2, PDGFRA, PDGFRB
45	signal transduction	GO:007165	INF	CCL11, CCL24, CCL13, ESR1, CRH, PDGFRB
46	cytokine-mediated signaling pathway	GO:019221	INF	CSF3, SOCS3, , ICAM1, IFNG, IFNA2
47	response to organic cyclic compound	GO:014070	INF	IL4, ICAM1, PTGS2, AHR, , SOCS3
48	response to drug	GO:042493	INF	PTGS2, LTC4S, TGFB1, , SOCS3, ICAM1
49	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	INF	SRF, , ESR1, IL5, IL4, IL1B
50	positive regulation of cell proliferation	GO:008284	INF	PDGFRB, EGFR, TGFB1, PRTN3, CSF1, CSF2

Molecular functions related to eosinophilia according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	INF	NOS2, PDGFRA, ACSL6, TYRP1, TGFB1, CSF1
2	protein binding	GO:005515	INF	GGT1, PDE4DIP, NOS2, CRH, SRF, CYBA
3	chemokine activity	GO:008009	10.7	CCL5, CCL13, CCL24, CCL3, CCL17, CCL11
4	CCR1 chemokine receptor binding	GO:031726	10.4	CCL5, CCL3, CCL7
5	carbohydrate binding	GO:030246	10.1	PRG2, THBD, IL2, CD69, CHIA, LGALS9
6	heparin binding	GO:008201	9.8	KNG1, PRG2, CCL5, CCL7, FGFR1, MPO
7	cytokine activity	GO:005125	9.8	IL9, IFNA2, IFNG, CSF1, CSF2, CSF3
8	growth factor activity	GO:008083	9.6	HGF, CSF3, CSF2, CSF1, TGFB3, TGFB1
9	protease binding	GO:002020	9.5	SELL, SERPINA1, BDKRB2, INS, MBP
10	receptor binding	GO:005102	9.5	NOS2, PDGFRB, POMC, NMU, KNG1, CRH
11	protein heterodimerization activity	GO:046982	9.2	AHR, TYRP1, TGFB1, TGFB3, HGF, EGFR
12	heme binding	GO:020037	9.2	EPX, TDO2, NOS2, CYBA, PTGS2, IDO1
13	protein tyrosine kinase activity	GO:004713	INF	ABL2, ABL1, EGFR, PDGFRB, , FGFR1
14	CCR5 chemokine receptor binding	GO:031730	INF	CCL3, CCL5,