MCID: ESN007
MIFTS: 60

Eosinophilia malady

Summaries for Eosinophilia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 0.45×109/L more...

MalaCards: Eosinophilia, also known as disorder characterized by eosinophilia, is related to eosinophilia-myalgia syndrome and pulmonary eosinophilia. An important gene associated with Eosinophilia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are PAK Pathway and Akt Signaling. The compounds histamine and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and myeloid, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Eosinophilia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

eosinophilia 8 10 44
disorder characterized by eosinophilia 60
eosinophilic leukocytosis 8
eosinophil count raised 8


External Ids:

Disease Ontology8 DOID:999
MeSH34 D004802
ICD9CM27 288.3

Related Diseases for Eosinophilia

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17GeneCards, 18GeneDecks
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Diseases in the Eosinophilia family:

Familial Eosinophilia

Diseases related to Eosinophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 403)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia-myalgia syndrome31.5IL5
2pulmonary eosinophilia31.5IL8, IL4, IL5, IL13, EPX, IGHE
3asthma31.0CCL11, IL13
4leukemia30.9EPX, RNASE3, CCL7, PRG2, IL4, PDGFRB
5esophagitis30.7IL13, CCL11, CCR3, PRG2, IL5
6angioedema30.6IGHE, RNASE3, IL5
7hepatitis30.5CCL11
8rhinitis30.5IL8, IL4, IL5, IL13, RNASE3, CYSLTR1
9allergic asthma30.5IL8, IL4, IL5, IL3, IL13, RNASE3
10dermatitis30.5CCL17, CCL11, IFNG, IGHE, IL4, IL5
11toxocariasis30.4IGHE, RNASE3
12eosinophilic esophagitis30.4IL5, CCL11
13allergic rhinitis30.3IL8, IL4, IL5, IL13, RNASE3, EPX
14pneumonia30.3IL8, CCL11, CCL17, CCL7, IL5, EPX
15strongyloidiasis30.3IL5, IGHE
16atopic dermatitis30.3IL8, IL4, IL5, IL13, RNASE3, CYSLTR1
17myeloid leukemia30.3IL3
18eosinophilic gastroenteritis30.3CCL11, IGHE, IL5
19eosinophilic pneumonia30.2IL5, IL3, IL13, RNASE3, IGHE, CCL17
20churg-strauss syndrome30.2CYSLTR1, RNASE3, IL5
21filariasis30.2IGHE, IL5, IL13
22bronchitis30.2RNASE3, CCL11, CCR3, IGHE, IL8, IL5
23vasculitis30.2PRG2, CYSLTR1
24graft versus host disease30.1IL3, IL4, IL13, IFNG
25sarcoma30.1PDGFRB
26pulmonary fibrosis30.0PDGFRB, IL8, IL13, CYSLTR1, CCL17, PRG2
27schistosomiasis30.0RNASE3, IGHE, IFNG, IL13, IL4, IL5
28kimura disease30.0IL5, RNASE3, IGHE, PRG2
29tuberculosis30.0IL4, EPX, IFNG, CCL7
30allergic bronchopulmonary aspergillosis30.0IL5, IGHE, IL4
31aspergillosis30.0IFNG
32meningitis30.0IL8
33food allergy30.0CCL11, IGHE, IL4, IL5, IL13, RNASE3
34allergic conjunctivitis30.0IL4, IL5, IL13, RNASE3, IGHE, CCL11
35arthritis30.0IL4, IL13, IFNG, IL8, CCR3
36sarcoidosis30.0CCL11, IL13, IFNG
37conjunctivitis30.0RNASE3, IGHE
38chronic eosinophilic pneumonia30.0IL5, RNASE3, CCL11
39omenn syndrome30.0IGHE, IL5, IL4
40toxic shock syndrome29.9IFNG
41endocarditis29.9EPX
42skin disease29.8IL8, IL4, IL5, IL13, RNASE3, IGHE
43ulcerative colitis29.8CCL17, CCL11, CCL7, IFNG, IL8, IL4
44rheumatoid arthritis29.8IL8, IL13, IFNG, RNASE3, PRG2, PDE4A
45bullous pemphigoid29.8PRG2, CCL11, RNASE3, CCL17, IL13, IL5
46bronchiolitis29.8CCL11, IL8, IL5, IL13, RNASE3, IGHE
47keratoconjunctivitis29.8IL5, IL13, RNASE3, CCL11
48urticaria29.8RNASE3, IGHE, PRG2
49onchocerciasis29.8IL5, RNASE3, EPX
50mycosis fungoides29.8CCL17, CCR3, IL5

Graphical network of the top 20 diseases related to Eosinophilia:



Diseases related to eosinophilia

Clinical Features for Eosinophilia

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Drugs & Therapeutics for Eosinophilia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Eosinophilia

Drug clinical trials:

Search ClinicalTrials for Eosinophilia

Search NIH Clinical Center for Eosinophilia

Search CenterWatch for Eosinophilia

Genetic Tests for Eosinophilia

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Anatomical Context for Eosinophilia

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32MalaCards
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MalaCards organs/tissues related to Eosinophilia:

32
Lung, T cells, Myeloid, Bone, Skin, Thyroid, Bone marrow, Liver, Testes, Heart, B cells, Brain, Endothelial, Monocytes, Colon, Whole blood, Lymph node, Kidney, Salivary gland, Skeletal muscle, Eye, Nk cells, Breast, Thymus, Prostate, Ovary, Spinal cord

Animal Models for Eosinophilia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eosinophilia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0IL8, CCL11, CCL17, CCR3, CCL7, IFNG
2MP:000539710.7CCL11, CCR3, CCL7, IFNG, PDGFRB, PRG2
3MP:000538810.6CYSLTR1, PRG2, CCL11

Publications for Eosinophilia

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50PubMed
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Articles related to Eosinophilia:

(show top 50)    (show all 1628)
idTitleAuthorsYear
1
Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome. (23866082)
2014
2
Increased FDG Uptake of the Bone Marrow Mimicking Malignancy in a Patient of Eosinophilia Secondary to Sparganum mansoni Infection. (23877523)
2013
3
Latex-specific IgE and its recombinant fractions in a child with cerebrospinal eosinophilia. (23838538)
2013
4
Nasal eosinophilia and serum soluble intercellular adhesion molecule 1 in patients with allergic rhinitis treated with montelukast alone or in combination with desloratadine or levocetirizine. (23562192)
2013
5
Ca(2+)-activated K(+) channel-3.1 blocker TRAM-34 attenuates airway remodeling and eosinophilia in a murine asthma model. (23204391)
2013
6
Effect of proton pump inhibitor on esophageal eosinophilia. (23325438)
2013
7
The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia. (22190185)
2012
8
Eosinophilia with organ involvement in 3 siblings. (23291489)
2012
9
Evidence for distinct histologic profile of nasal polyps with and without eosinophilia. (21898422)
2011
10
Angiolymphoid hyperplasia with eosinophilia treated with vascular laser. (21347722)
2011
11
Correlation of nasal smear eosinophilia with class of allergic rhinitis. (21532105)
2011
12
Eosinophilia in conjunctival tear fluid among patients with pollen allergy. (21875549)
2011
13
Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking. (21143513)
2011
14
Implications of eosinophilia in the normal duodenal biopsy - an association with allergy and functional dyspepsia. (20222916)
2010
15
Colonic angiolymphoid hyperplasia with eosinophilia masquerading as malignancy: a case report and review of the literature. (20643624)
2010
16
Levels of circulating IL-33 and eosinophil cationic protein in patients with hypereosinophilia or pulmonary eosinophilia. (20719375)
2010
17
Vasospastic angina: nocturnal chest pain, eosinophilia and delayed diagnosis. (19965326)
2009
18
VCAM-1 and eosinophilia in diffuse sino-nasal polyps. (18642014)
2009
19
Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome induced by celecoxib and anti-tuberculosis drugs. (18583892)
2008
20
Cytokine-mediated apoptosis of granulocytes eosinophilicus in eosinophilia]. (18409371)
2008
21
Primary cutaneous CD30 anaplastic large cell lymphoma with keratoacanthoma-like pseudocarcinomatous hyperplasia and marked eosinophilia and neutrophilia. (15186435)
2004
22
Immune responses to the nonglycosylated ectodomain of respiratory syncytial virus attachment glycoprotein mediate pulmonary eosinophilia in inbred strains of mice with different MHC haplotypes. (12696122)
2003
23
Clonal T-helper lymphocytes and elevated IL-5 levels in episodic angioedema and eosinophilia (Gleich's syndrome). (14565669)
2003
24
Innate and cognate mechanisms of pulmonary eosinophilia in helminth infection. (11981825)
2002
25
In childhood asthma the degree of allergen-induced T-lymphocyte proliferation is related to serum IgE levels and to blood eosinophilia. (10795651)
2000
26
The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice. (10792366)
2000
27
Angiolymphoid hyperplasia with eosinophilia associated with arteriovenous malformation: a clinicopathological correlation with angiography and serial estimation of serum levels of renin, eosinophil cationic protein and interleukin 5. (10354088)
1999
28
Antiphospholipid antibodies in patients with eosinophilia myalgia and toxic oil syndrome. (9002013)
1997
29
Eosinophilia-Myalgia Syndrome: Review and Reappraisal of Clinical, Epidemiologic and Animal Studies Symposium. Washington, D.C., USA, December 7-8, 1994. Proceedings. (9053528)
1996
30
Syndrome resembling tropical pulmonary eosinophilia but of non-filarial aetiology: serological findings with filarial antigens. (8560543)
1995
31
Psychiatric aspects of the eosinophilia-myalgia syndrome. (7871130)
1995
32
A case of pulmonary infiltration with eosinophilia (PIE) syndrome associated with syndrome of inappropriate secretion of ADH (SIADH) in the elderly patient]. (8551692)
1995
33
1,1'-Ethylidenebis[L-tryptophan], a contaminant implicated in L-tryptophan eosinophilia myalgia syndrome, suppresses mRNA expression of hypothalamic corticotropin-releasing hormone in Lewis (LEW/N) rat brain. (8528886)
1994
34
L-tryptophan and the eosinophilia-myalgia syndrome: a clinical and laboratory study. (7892779)
1994
35
Toxic oil syndrome and eosinophilia-myalgia syndrome: May 8-10, 1991, World Health Organization meeting report. (8266108)
1993
36
3-(Phenylamino)alanine, a novel aniline-derived amino acid associated with the eosinophilia-myalgia syndrome: a link to the toxic oil syndrome? (1469924)
1992
37
Pathologic manifestations of the eosinophilia myalgia syndrome: analysis of 11 cases. (1563745)
1992
38
L-tryptophan-induced eosinophilia-myalgia syndrome. (1829754)
1991
39
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (1994219)
1991
40
Blood and bone marrow eosinophilia in malignant tumors. Role and nature of blood and tissue eosinophil colony-stimulating factor(s) in two patients. (2065275)
1991
41
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
42
The eosinophilia-myalgia-syndrome and L-tryptophan containing products: a case report and review of the literature. (2204559)
1990
43
Evidence for the neoplastic involvement of monocytic, eosinophilic and basophilic lineages in acute myelomonocytic leukemia with eosinophilia. (2109454)
1990
44
Airway hyperreactivity in tropical pulmonary eosinophilia. (3359833)
1988
45
A case history: Pulmonary eosinophilia and coccidiodal infections. (3677833)
1987
46
Hepatic involvement in tropical pulmonary eosinophilia. (6501178)
1984
47
Wells' syndrome. Recurrent granulomatous dermatitis with eosinophilia. (443839)
1979
48
Pulmonary eosinophilia in a patient receiving beclomethasone dipropionate aerosol. (453651)
1979
49
Myelitis following arsenic therapy in pulmonary eosinophilia. (13017551)
1952
50
A syndrome characterized by generalized cutaneous eruption, chorioretinitis and eosinophilia, probably due to chronic toxoplasma infection. (18139423)
1949

Genetic Variations for Eosinophilia

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Expression for genes affiliated with Eosinophilia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilia

Search GEO for disease gene expression data for Eosinophilia.

Pathways for genes affiliated with Eosinophilia

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51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Eosinophilia according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9CCL11, IL8, IL4, IL5, IL3, IL13
2
Hide members
10.9IL4, IL5, IL3, IL13, PDGFRB, CCL7
3
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10.8IL4, CCL11, IFNG, PRG2, EPX, RNASE3
4
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10.8CCL11, CCL17, CCR3, CCL7, PDGFRB, IL13
5
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10.8CCL11, CCL17, CCR3, CCL7, PDE4A, PDGFRB
6
Hide members
10.8CCL11, IFNG, IGHE, IL13, IL3, IL5
710.7IFNG, IL13, IL3, IL5, IL4, IL8
8
Hide members
10.7CCL17, CCR3, CCL7, PDGFRB, PRG2, IL5
9
Hide members
10.7CCL11, CCL17, CCR3, CCL7, CYSLTR1, IL8
10
Hide members
10.7CCL11, CCL17, CCR3, CCL7, PRG2, IL8
1110.7IFNG, IL13, IL3, IL5, IL4
12
Hide members
10.7IL8, IL4, IL5, IL3, IFNG
1310.7IFNG, IL13, IL5, IL4, IL8
14
Hide members
10.7CCL11, CCL17, CCL7, IL13, IL5
1510.7CCL11, CCL17, IGHE, IL5, IL4
1610.7CCL11, CCL17, CCR3, CCL7, IL8
17
Hide members
10.7CCL11, CCL17, CCR3, CCL7, IL8
1810.6CCL11, IL5, IL4, IL8
19
Hide members
10.6IL4, IL5, IL13, IFNG
2010.6IL4, IL5, IL13, IFNG
21
Immune response CCR3 signaling in eosinophils
Hide members
10.6IL8, CCL7, CCR3, CCL11
2210.6IL4, IL5, IL3
2310.6IL4, IL5, IL13
2410.6IL4, IL5, IFNG
2510.6CCL11, IL4, IL8

Compounds for genes affiliated with Eosinophilia

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44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 2BitterDB
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Compounds related to Eosinophilia according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2413.5CCR3, CCL7, IFNG, PDE4A, PRG2, IGHE
2dexamethasone44 49 28 1114.5CCL17, CCL11, EPX, CYSLTR1, IL8, IL13
3leukotriene b444 59 2413.3CCL11, CCL7, PDE4A, EPX, CYSLTR1, RNASE3
4fmlp4411.3CCL11, CCL7, PDE4A, PRG2, EPX, RNASE3
5budesonide44 49 1113.3CCL11, IFNG, PDE4A, IGHE, EPX, RNASE3
6actinomycin d4411.3IL3, IL4, IL8, IFNG, CCL11, CCR3
7cyclosporin a44 28 5913.3IL4, IL8, IL5, IL3, IL13, RNASE3
8tarc4411.3CCL11, CCL17, CCR3, CCL7, IFNG, IGHE
9allergens4411.3CCL11, CCL17, IFNG, PRG2, IGHE, EPX
10pgd24411.3CCL11, CCR3, PRG2, IGHE, EPX, CYSLTR1
11salbutamol44 49 28 11 2415.3RNASE3, IL13, IL5, IL8, CYSLTR1, EPX
12fluticasone propionate44 49 59 1114.2IL8, IL4, IL5, CCL11, IFNG, IGHE
13tyrosine4411.2CCL7, PDE4A, CYSLTR1, PRG2, EPX, CCL11
14methacholine44 1112.2IL8, IL4, CCL11, PRG2, IGHE, RNASE3
15ltc44411.2IL5, IL3, IL13, CCL11, PRG2, EPX
16montelukast44 49 28 1114.2CCL11, IGHE, CYSLTR1, RNASE3, IL13, IL5
17salmeterol44 49 28 1114.2CCL11, PDE4A, EPX, RNASE3, IL13, IL5
18retinoic acid44 2412.2CCL11, PRG2, IL5, IFNG, PDE4A, PDGFRB
19genistein44 28 59 2 11 2416.1PRG2, IFNG, IL5, IL8, PDGFRB, CCL7
20il 104411.1IL5, IL4, IL13, IFNG, CCL17, IL8
21rantes4411.1IL3, CCL11, IL4, RNASE3, IFNG, CCL7
22ccl344 2812.1CCL11, CCL17, CCR3, CCL7, IFNG, IL13
23cetirizine44 28 11 2414.1RNASE3, EPX, IGHE, CCL11, IL5, IL8
24nedocromil sodium4411.1IL3, IGHE, RNASE3, IL5, IL4, IL8
25ketotifen44 1112.1RNASE3, EPX, IL5, IGHE, PDE4A, CCL11
26ltd44411.1CCR3, IL3, CYSLTR1, RNASE3, IL13, IL5
27heparin44 28 11 2414.1CCR3, PRG2, IL8, RNASE3, EPX, IL13
28prednisolone44 28 1113.0CCL11, IFNG, IGHE, EPX, RNASE3, IL13
29lte44411.0EPX, CCL11, CYSLTR1, RNASE3, IL5
30poly(i-c)4411.0CCL11, IFNG, IL5, IL4, IL8, IL3
31sodium cromoglycate4411.0IGHE, EPX, RNASE3, IL5, CCL11
32formoterol44 28 1113.0IL8, IL13, RNASE3, PDE4A, IL4
33pranlukast44 28 1113.0CYSLTR1, RNASE3, IL5, IL4, CCL11
34rolipram44 59 2813.0PDE4A, EPX
35pge24411.0EPX, PDE4A, CCL11, CYSLTR1
36praziquantel44 1112.0IGHE, IL4, IL5, IL13, RNASE3
37herbimycin a44 5912.0CCL11, CCR3, IL3, IL5, IL4, IL8
38azelastine44 1111.9IL4, IL5, IL3, IGHE, RNASE3
39vegf4410.9IL4, IL5, IL13, RNASE3, IGHE, PDGFRB
40indomethacin44 59 28 1113.9PRG2, IL5
41il-124410.9IL8, IL13, IFNG, IL4, IL5
42gm-csf44 2811.9IFNG
43hydrocortisone44 2 59 1113.8IGHE, IL8
44theophylline44 28 11 2413.8IL5, IL13, RNASE3, EPX, CYSLTR1, PDE4A
45unicap4410.8IGHE, RNASE3, IL5, CCL11
46omalizumab44 1111.8IGHE, IL13, IL5, IL4
47tacrolimus44 49 1112.8IL4, IL5, IL3, IL13, IFNG, CCL17
48anaphylatoxin4410.7CCL7, IL8, IL4, RNASE3, IL3
49ly2940024410.5CCL11, PDE4A, PDGFRB, IL13, IL3, IL8
50cycloheximide4410.4PDE4A

GO Terms for genes affiliated with Eosinophilia

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16Gene Ontology
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Cellular components related to Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.9CCL17, CCL7, IFNG, PRG2, IGHE, RNASE3
2extracellular spaceGO:00561510.6IL8, CCL11, CCL17, CCR3, CCL7, IFNG

Biological processes related to Eosinophilia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.1IL8, CCL11, CCL17, CCL7, PRG2, IGHE
2inflammatory responseGO:00695411.1CCL11, CCL17, CCR3, CCL7, CYSLTR1, IL13
3chemotaxisGO:00693511.0CCL11, CCL17, CCR3, CCL7, CYSLTR1, IL4
4eosinophil chemotaxisGO:04824510.8CCL7, CCR3, CCL11
5positive regulation of B cell proliferationGO:03089010.8IL13, IL5, IL4
6mast cell chemotaxisGO:00255110.8CCR3, CCL11
7regulation of proton transportGO:01015510.7IL4, IL13
8positive regulation of isotype switching to IgG isotypesGO:04830410.7IFNG, IL4
9positive regulation of MHC class II biosynthetic processGO:04534810.7IL4, IFNG
10cell-cell signalingGO:00726710.6CCL17, CCL7, IL13, IL3
11positive regulation of chemokine biosynthetic processGO:04508010.6IL4, IFNG
12signal transductionGO:00716510.6CCL11, CCL7, PDE4A, PDGFRB, IL13, IL8
13cellular component movementGO:00692810.6IL8, IL13, IFNG
14positive regulation of angiogenesisGO:04576610.3CYSLTR1, CCR3, CCL11

Molecular functions related to Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7IL4, IL5, IL3, IL13, IFNG
2chemokine activityGO:00800910.3IL8, CCL7, CCL17, CCL11

Products for genes affiliated with Eosinophilia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eosinophilia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet