MCID: ESN007
MIFTS: 54

Eosinophilia malady

Summaries for Eosinophilia

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 0.45×109/L more...

MalaCards: Eosinophilia, also known as disorder characterized by eosinophilia, is related to eosinophilia-myalgia syndrome and asthma. An important gene associated with Eosinophilia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are PAK Pathway and Akt Signaling. The compounds histamine and dexamethasone have been mentioned in the context of this disorder. Related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Eosinophilia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM
See all sources

Aliases & Descriptions:

eosinophilia 8 10 45
disorder characterized by eosinophilia 61
eosinophilic leukocytosis 8
eosinophil count raised 8


External Ids:

Disease Ontology8 DOID:999
MeSH35 D004802
ICD9CM27 288.3

Related Diseases for Eosinophilia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Eosinophilia family:

familial eosinophilia

Diseases related to Eosinophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 400)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia-myalgia syndrome31.5IL5
2asthma31.1CCL11, IL13
3angioedema30.6IGHE, RNASE3, IL5
4allergic asthma30.5IL8, IL4, IL5, IL3, IL13, RNASE3
5hypereosinophilic syndrome30.5IL3, IL5, PDGFRB
6eosinophilic fasciitis30.5IL5
7toxocariasis30.5IGHE, RNASE3
8allergic rhinitis30.4IL8, IL4, IL5, IL13, RNASE3, EPX
9strongyloidiasis30.4IL5, IGHE
10atopic dermatitis30.4IL8, IL4, IL5, IL13, RNASE3, CYSLTR1
11eosinophilic esophagitis30.3IL5, CCL11
12kimura disease30.3IL5, RNASE3, IGHE, PRG2
13eosinophilic gastroenteritis30.3CCL11, IGHE, IL5
14mastocytosis30.3IL13, IGHE, IL5, PDGFRB
15churg-strauss syndrome30.3CYSLTR1, RNASE3, IL5
16bronchitis30.2RNASE3, CCL11, CCR3, IGHE, IL8, IL5
17vasculitis30.2PRG2, CYSLTR1
18graft versus host disease30.2IL3, IL4, IL13, IFNG
19hepatitis c30.2IFNG
20sinusitis30.1IL5, RNASE3, CYSLTR1, IGHE, PRG2, CCL11
21tuberculosis30.1IL4, EPX, IFNG, CCL7
22allergic bronchopulmonary aspergillosis30.1IL5, IGHE, IL4
23aspergillosis30.1IFNG
24allergic conjunctivitis30.0IL4, IL5, IL13, RNASE3, IGHE, CCL11
25arthritis30.0IL4, IL13, IFNG, IL8, CCR3
26helminthiasis30.0RNASE3, IGHE, IL5, IL13
27chronic eosinophilic pneumonia30.0IL5, RNASE3, CCL11
28omenn syndrome30.0IGHE, IL5, IL4
29toxic shock syndrome30.0IFNG
30atopy29.9CCL11, CCL17, IL4, IL5, IL13, RNASE3
31ulcerative colitis29.9CCL17, CCL11, CCL7, IFNG, IL8, IL4
32vernal keratoconjunctivitis29.9CCL11, IGHE, IL8, IL4, IL5, IL3
33bullous pemphigoid29.9PRG2, CCL11, RNASE3, CCL17, IL13, IL5
34bronchiolitis29.9CCL11, IL8, IL5, IL13, RNASE3, IGHE
35urticaria29.9RNASE3, IGHE, PRG2
36onchocerciasis29.9IL5, RNASE3, EPX
37mycosis fungoides29.9CCL17, CCR3, IL5
38systemic scleroderma29.9PDGFRB, IL13, IL4, CCL7
39hepatitis b29.9IFNG
40folliculitis29.9CCL11
41thrombocytopenia29.9IL3
42atherosclerosis29.6PDE4A, CCR3, PDGFRB, IL8, CCL11
43intrinsic asthma29.6IL4, IL5, RNASE3, IGHE
44hyper ige syndrome29.6IL4, RNASE3, IGHE, IFNG
45uveitis29.6IFNG, IL4, CCL11
46paragonimiasis29.6IL5, IGHE, CCL17
47common cold29.6IL8, RNASE3, CCL11
48myelodysplastic syndromes29.6PDGFRB, PDE4A, IL3
49pulmonary alveolar proteinosis29.6IL3
50adenocarcinoma29.6PDGFRB

Graphical network of the top 20 diseases related to Eosinophilia:



Diseases related to eosinophilia

Clinical Features for Eosinophilia

Drugs & Therapeutics for Eosinophilia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Eosinophilia

Drug clinical trials:

Search ClinicalTrials for Eosinophilia

Search NIH Clinical Center for Eosinophilia

Search CenterWatch for Eosinophilia

Genetic Tests for Eosinophilia

Anatomical Context for Eosinophilia

Animal Models for Eosinophilia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Eosinophilia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0IL8, CCL11, CCL17, CCR3, CCL7, IFNG
2MP:000539710.7CCL11, CCR3, CCL7, IFNG, PDGFRB, PRG2
3MP:000538810.6CYSLTR1, PRG2, CCL11

Publications for Eosinophilia

Sources:
51PubMed
See all sources

Articles related to Eosinophilia:

(show top 50)    (show all 1628)
idTitleAuthorsYear
1
Letter: PPI-responsive oesophageal eosinophilia - from initial skepticism to consistent prospective data; authors' reply. (24330242)
2014
2
Mean platelet volume and eosinophilia relationship in patients with bullous pemphigoid. (23574380)
2013
3
Duodenal eosinophilia and Early Satiety in Functional Dyspepsia: Confirmation of a Positive Association in an Australian Cohort. (24304041)
2013
4
Eosinophilia: A poor predictor of Strongyloides infection in refugees. (24421809)
2013
5
Digital Vasculitis with Eosinophilia Possibly Associated with Etanercept Therapy. (23824408)
2013
6
Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia. (23931643)
2013
7
Angiolymphoid hyperplasia with eosinophilia of the external ear: case report and review of the literature. (23842604)
2013
8
Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1. (23400675)
2013
9
Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma. (23452625)
2013
10
Interleukin-17 drives pulmonary eosinophilia following repeated exposure to Aspergillus fumigatus conidia. (22252873)
2012
11
Marked eosinophilia due to intestinal strongyloidiasis in an immunocompetent patient. (23292062)
2012
12
Levetiracetam-induced drug reaction with eosinophilia and systemic symptoms syndrome. (22764327)
2012
13
Ulnar mononeuropathy associated with eosinophilia. (22525452)
2012
14
Interferon-alpha inhibits airway eosinophilia and hyperresponsiveness in an animal asthma model [corrected]. (23130331)
2012
15
Eleven cases of angioedema with eosinophilia treated in a single hospital in Japan. (22361512)
2012
16
A case of drug rash with eosinophilia and systemic symptoms (DRESS) syndrome complicating airway management. (22271506)
2012
17
Toxocara canis infection is associated with eosinophilia and total IgE in blood donors from a large Brazilian centre. (21410848)
2011
18
Central nervous system problems with eosinophilia. (22159066)
2011
19
Comparison of the causes and clinical features of drug rash with eosinophilia and systemic symptoms and stevens-johnson syndrome. (20358026)
2010
20
Angiolymphoid hyperplasia with eosinophilia affecting the scrotum: a rare case report with molecular evidence of T-cell clonality. (20507406)
2010
21
Drug rash with eosinophilia and systemic symptoms (DRESS): changing carbamazepine to phenobarbital controlled epilepsy without the recurrence of DRESS. (20103499)
2010
22
Eosinophilia and eosinophilic infiltration into splenic B-cell high-grade lymphoma in a dog. (20467202)
2010
23
Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants. (20713961)
2010
24
Folliculotropic mycosis fungoides with eosinophilia and CD30+ large-cell transformation: a case with a fatal outcome presenting with multifocal lesions and leonine facies. (19925483)
2010
25
Severe vancomycin-induced drug rash with eosinophilia and systemic symptoms syndrome imitating septic shock. (19424074)
2009
26
Angiolymphoid hyperplasia with eosinophilia masquerading as Kimura disease. (15888362)
2005
27
Simple pulmonary eosinophilia evaluated by means of FDG PET: the findings of 14 cases. (16374077)
2005
28
Possible drug rash with eosinophilia and systemic symptoms syndrome after exposure to epoetin alfa. (16303911)
2005
29
Secondary amyloidosis and eosinophilia in a patient with uterine leiomyosarcoma. (16172171)
2005
30
Drug rash with eosinophilia and systemic symptoms syndrome and renal toxicity with a nevirapine-containing regimen in a pregnant patient with human immunodeficiency virus. (12738113)
2003
31
A case of multicentric Castleman's disease demonstrating severe eosinophilia and enhanced production of interleukin-5. (12581193)
2003
32
Pathogenic roles of eosinophils in guinea-pig contact sensitivity: regulation of dermal eosinophilia with remotely administered IL-5. (11122232)
2000
33
Progressive eosinophilia and elevated IgE in enterobiasis. (10435486)
1999
34
Pathogenesis of tropical pulmonary eosinophilia: parasitic alveolitis and parallels with asthma. (9519215)
1998
35
Allergen immunotherapy inhibits airway eosinophilia and hyperresponsiveness associated with decreased IL-4 production by lymphocytes in a murine model of allergic asthma. (9761759)
1998
36
5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rats. (9854052)
1998
37
Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. (9034156)
1997
38
Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. (9076948)
1997
39
Detection of living adult Wuchereria bancrofti in a patient with tropical pulmonary eosinophilia. (9181082)
1996
40
Eosinophilia as a marker of adrenal insufficiency in the surgical intensive care unit. (8957461)
1996
41
Pulmonary eosinophilia in pulmonary tuberculosis. (1600796)
1992
42
Effect of synthesized constituents in the L-tryptophan product on the differentiation of eosinophils and the induction of IL-6: a possible cause of eosinophilia-myalgia syndrome. (1872826)
1991
43
L-tryptophan-induced eosinophilia-myalgia syndrome. II. Partial correction of abnormal tryptophan metabolism by pyridoxine. (1722762)
1991
44
Abnormalities of the coronary arteries, neural structures and conduction system of the heart observed postmortem in the eosinophilia-myalgia syndrome, with a discussion of comparative findings from the toxic oil syndrome. (2130570)
1991
45
Release of granule proteins by eosinophils from allergic and nonallergic patients with eosinophilia on immunoglobulin-dependent activation. (1890265)
1991
46
Pulmonary eosinophilia and granulomatous pulmonary arteritis induced in rats by intravenous Sephadex. (1698322)
1990
47
Gastroenteritis with eosinophilia caused by Giardia lamblia]. (2244060)
1990
48
Eosinophilia-Myalgia syndrome associated with tryptophan. (2356501)
1990
49
Pulmonary eosinophilia associated with cutaneous larva migrans. (3969661)
1985
50
Microfilarial granuloma of the breast in a patient with tropical pulmonary eosinophilia. (869111)
1977

Genetic Variations for Eosinophilia

Expression for genes affiliated with Eosinophilia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Eosinophilia

Search GEO for disease gene expression data for Eosinophilia.

Pathways for genes affiliated with Eosinophilia

Sources:
52QIAGEN, 30KEGG, 54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Pathways related to Eosinophilia according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9IL8, IL4, IL5, IL3, IL13, PDGFRB
2
Hide members
10.9CCL17, CCR3, IL13, PDGFRB, CCL11, IL3
3
Hide members
10.8CCL11, PRG2, EPX, RNASE3, IFNG, IL13
4
Hide members
10.8IL13, PDGFRB, IL3, IL5, CCR3, CCL17
5
Hide members
10.8CCL17, CYSLTR1, PDGFRB, PDE4A, CCL7, CCR3
6
Hide members
10.8IL3, IGHE, IL13, IL4, CCL11, IFNG
710.7IFNG, IL8, IL4, IL5, IL3, IL13
8
Hide members
10.7PRG2, PDGFRB, CCL7, CCR3, IL5, CCL17
9
Hide members
10.7CCL7, CCL11, CCR3, CYSLTR1, IL8, CCL17
10
Hide members
10.7IL8, PRG2, CCL7, CCR3, CCL17, CCL11
1110.7IL4, IL5, IL3, IL13, IFNG
12
Hide members
10.7IL4, IL5, IL8, IL3, IFNG
1310.7IL4, IL5, IFNG, IL8, IL13
14
Hide members
10.7IL5, CCL11, IL13, CCL7, CCL17
1510.7IL4, CCL11, CCL17, IGHE, IL5
16
Hide members
10.7CCL11, CCR3, CCL7, IL8, CCL17
1710.7IL8, CCL7, CCL17, CCL11, CCR3
1810.6CCL11, IL4, IL8, IL5
1910.6IL4, IL13, IFNG, IL5
20
Hide members
10.6IL4, IL5, IL13, IFNG
21
Immune response CCR3 signaling in eosinophils
Hide members
10.6CCL11, CCR3, CCL7, IL8
2210.6IL4, IL5, IL3
2310.6IL4, IL5, IL13
2410.6IFNG, IL4, IL5
2510.6IL8, CCL11, IL4

Compounds for genes affiliated with Eosinophilia

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Eosinophilia according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1histamine45 29 2413.5CCR3, CCL7, IFNG, PDE4A, PRG2, IGHE
2dexamethasone45 50 29 1114.5CCL17, CCL11, EPX, CYSLTR1, IL8, IL13
3leukotriene b445 60 2413.3CCL11, CCL7, PDE4A, EPX, CYSLTR1, RNASE3
4fmlp4511.3CCL11, CCL7, PDE4A, PRG2, EPX, RNASE3
5budesonide45 50 1113.3CCL11, IFNG, PDE4A, IGHE, EPX, RNASE3
6actinomycin d4511.3IL3, IL4, IL8, IFNG, CCL11, CCR3
7cyclosporin a45 29 6013.3IL4, IL8, IL5, IL3, IL13, RNASE3
8tarc4511.3CCL11, CCL17, CCR3, CCL7, IFNG, IGHE
9allergens4511.3CCL11, CCL17, IFNG, PRG2, IGHE, EPX
10pgd24511.3CCL11, CCR3, PRG2, IGHE, EPX, CYSLTR1
11salbutamol45 50 29 11 2415.3RNASE3, IL13, IL5, IL8, CYSLTR1, EPX
12fluticasone propionate45 50 60 1114.2IL8, IL4, IL5, CCL11, IFNG, IGHE
13tyrosine4511.2CCL7, PDE4A, CYSLTR1, PRG2, EPX, CCL11
14methacholine45 1112.2IL8, IL4, CCL11, PRG2, IGHE, RNASE3
15ltc44511.2IL5, IL3, IL13, CCL11, PRG2, EPX
16montelukast45 50 29 1114.2CCL11, IGHE, CYSLTR1, RNASE3, IL13, IL5
17salmeterol45 50 29 1114.2CCL11, PDE4A, EPX, RNASE3, IL13, IL5
18retinoic acid45 2412.2CCL11, PRG2, IL5, IFNG, PDE4A, PDGFRB
19genistein45 29 60 2 11 2416.1PRG2, IFNG, IL5, IL8, PDGFRB, CCL7
20il 104511.1IL5, IL4, IL13, IFNG, CCL17, IL8
21rantes4511.1IL3, CCL11, IL4, RNASE3, IFNG, CCL7
22ccl345 2912.1CCL11, CCL17, CCR3, CCL7, IFNG, IL13
23cetirizine45 29 11 2414.1RNASE3, EPX, IGHE, CCL11, IL5, IL8
24nedocromil sodium4511.1IL3, IGHE, RNASE3, IL5, IL4, IL8
25ketotifen45 1112.1RNASE3, EPX, IL5, IGHE, PDE4A, CCL11
26ltd44511.1CCR3, IL3, CYSLTR1, RNASE3, IL13, IL5
27heparin45 29 11 2414.1CCR3, PRG2, IL8, RNASE3, EPX, IL13
28prednisolone45 29 1113.0CCL11, IFNG, IGHE, EPX, RNASE3, IL13
29lte44511.0EPX, CCL11, CYSLTR1, RNASE3, IL5
30poly(i-c)4511.0CCL11, IFNG, IL5, IL4, IL8, IL3
31sodium cromoglycate4511.0IGHE, EPX, RNASE3, IL5, CCL11
32formoterol45 29 1113.0IL8, IL13, RNASE3, PDE4A, IL4
33pranlukast45 29 1113.0CYSLTR1, RNASE3, IL5, IL4, CCL11
34rolipram45 60 2913.0PDE4A, EPX
35pge24511.0EPX, PDE4A, CCL11, CYSLTR1
36praziquantel45 1112.0IGHE, IL4, IL5, IL13, RNASE3
37herbimycin a45 6012.0CCL11, CCR3, IL3, IL5, IL4, IL8
38azelastine45 1111.9IL4, IL5, IL3, IGHE, RNASE3
39vegf4510.9IL4, IL5, IL13, RNASE3, IGHE, PDGFRB
40indomethacin45 60 29 1113.9PRG2, IL5
41il-124510.9IL8, IL13, IFNG, IL4, IL5
42gm-csf45 2911.9IFNG
43hydrocortisone45 2 60 1113.8IGHE, IL8
44theophylline45 29 11 2413.8IL5, IL13, RNASE3, EPX, CYSLTR1, PDE4A
45unicap4510.8IGHE, RNASE3, IL5, CCL11
46omalizumab45 1111.8IGHE, IL13, IL5, IL4
47tacrolimus45 50 1112.8IL4, IL5, IL3, IL13, IFNG, CCL17
48anaphylatoxin4510.7CCL7, IL8, IL4, RNASE3, IL3
49ly2940024510.5CCL11, PDE4A, PDGFRB, IL13, IL3, IL8
50cycloheximide4510.4PDE4A

GO Terms for genes affiliated with Eosinophilia

Sources:
16Gene Ontology
See all sources

Cellular components related to Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.9CCL11, CCL17, IL5, IL3, IL13, RNASE3
2extracellular spaceGO:00561510.6CCL11, IL4, IL5, IL3, IL13, IFNG

Biological processes related to Eosinophilia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.1IL5, IL4, IL3, CCL11, IL13, IGHE
2inflammatory responseGO:00695411.1CCR3, CCL17, CCL7, IL13, IL5, IL8
3chemotaxisGO:00693511.0CCL7, CCL11, CCL17, CCR3, CYSLTR1, IL4
4eosinophil chemotaxisGO:04824510.8CCL7, CCL11, CCR3
5positive regulation of B cell proliferationGO:03089010.8IL5, IL4, IL13
6regulation of proton transportGO:01015510.8IL13, IL4
7mast cell chemotaxisGO:00255110.7CCR3, CCL11
8positive regulation of isotype switching to IgG isotypesGO:04830410.7IFNG, IL4
9positive regulation of MHC class II biosynthetic processGO:04534810.7IFNG, IL4
10cell-cell signalingGO:00726710.6CCL17, CCL7, IL13, IL3
11positive regulation of chemokine biosynthetic processGO:04508010.6IFNG, IL4
12signal transductionGO:00716510.6IL8, IL13, PDGFRB, PDE4A, CCL7, CCL11
13cellular component movementGO:00692810.6IL8, IL13, IFNG
14positive regulation of angiogenesisGO:04576610.3CCR3, CCL11, CYSLTR1

Molecular functions related to Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7IL4, IL5, IL3, IL13, IFNG
2chemokine activityGO:00800910.3IL8, CCL7, CCL17, CCL11

Products for genes affiliated with Eosinophilia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eosinophilia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet