MCID: ESN007
MIFTS: 60

Eosinophilia malady

Summaries for Eosinophilia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 0.45×109/L more...

MalaCards: Eosinophilia, also known as disorder characterized by eosinophilia, is related to eosinophilia-myalgia syndrome and pulmonary eosinophilia. An important gene associated with Eosinophilia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are PAK Pathway and Akt Signaling. The compounds histamine and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and myeloid, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Eosinophilia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

eosinophilia 8 10 44
disorder characterized by eosinophilia 60
eosinophilic leukocytosis 8
eosinophil count raised 8


External Ids:

Disease Ontology8 DOID:999
MeSH34 D004802
ICD9CM27 288.3

Related Diseases for Eosinophilia

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17GeneCards, 18GeneDecks
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Diseases in the Eosinophilia family:

Familial Eosinophilia

Diseases related to Eosinophilia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 403)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia-myalgia syndrome31.5IL5
2pulmonary eosinophilia31.5IL8, IL4, IL5, IL13, EPX, IGHE
3asthma31.0CCL11, IL13
4leukemia30.9EPX, RNASE3, CCL7, PRG2, IL4, PDGFRB
5esophagitis30.7IL13, CCL11, CCR3, PRG2, IL5
6angioedema30.6IGHE, RNASE3, IL5
7hepatitis30.5CCL11
8rhinitis30.5IL8, IL4, IL5, IL13, RNASE3, CYSLTR1
9allergic asthma30.5IL8, IL4, IL5, IL3, IL13, RNASE3
10dermatitis30.5CCL17, CCL11, IFNG, IGHE, IL4, IL5
11toxocariasis30.4IGHE, RNASE3
12eosinophilic esophagitis30.4IL5, CCL11
13allergic rhinitis30.3IL8, IL4, IL5, IL13, RNASE3, EPX
14pneumonia30.3IL8, CCL11, CCL17, CCL7, IL5, EPX
15strongyloidiasis30.3IL5, IGHE
16atopic dermatitis30.3IL8, IL4, IL5, IL13, RNASE3, CYSLTR1
17myeloid leukemia30.3IL3
18eosinophilic gastroenteritis30.3CCL11, IGHE, IL5
19eosinophilic pneumonia30.2IL5, IL3, IL13, RNASE3, IGHE, CCL17
20churg-strauss syndrome30.2CYSLTR1, RNASE3, IL5
21filariasis30.2IGHE, IL5, IL13
22bronchitis30.2RNASE3, CCL11, CCR3, IGHE, IL8, IL5
23vasculitis30.2PRG2, CYSLTR1
24graft versus host disease30.1IL3, IL4, IL13, IFNG
25sarcoma30.1PDGFRB
26pulmonary fibrosis30.0PDGFRB, IL8, IL13, CYSLTR1, CCL17, PRG2
27schistosomiasis30.0RNASE3, IGHE, IFNG, IL13, IL4, IL5
28kimura disease30.0IL5, RNASE3, IGHE, PRG2
29tuberculosis30.0IL4, EPX, IFNG, CCL7
30allergic bronchopulmonary aspergillosis30.0IL5, IGHE, IL4
31aspergillosis30.0IFNG
32meningitis30.0IL8
33food allergy30.0CCL11, IGHE, IL4, IL5, IL13, RNASE3
34allergic conjunctivitis30.0IL4, IL5, IL13, RNASE3, IGHE, CCL11
35arthritis30.0IL4, IL13, IFNG, IL8, CCR3
36sarcoidosis30.0CCL11, IL13, IFNG
37conjunctivitis30.0RNASE3, IGHE
38chronic eosinophilic pneumonia30.0IL5, RNASE3, CCL11
39omenn syndrome30.0IGHE, IL5, IL4
40toxic shock syndrome29.9IFNG
41endocarditis29.9EPX
42skin disease29.8IL8, IL4, IL5, IL13, RNASE3, IGHE
43ulcerative colitis29.8CCL17, CCL11, CCL7, IFNG, IL8, IL4
44rheumatoid arthritis29.8IL8, IL13, IFNG, RNASE3, PRG2, PDE4A
45bullous pemphigoid29.8PRG2, CCL11, RNASE3, CCL17, IL13, IL5
46bronchiolitis29.8CCL11, IL8, IL5, IL13, RNASE3, IGHE
47keratoconjunctivitis29.8IL5, IL13, RNASE3, CCL11
48urticaria29.8RNASE3, IGHE, PRG2
49onchocerciasis29.8IL5, RNASE3, EPX
50mycosis fungoides29.8CCL17, CCR3, IL5

Graphical network of the top 20 diseases related to Eosinophilia:



Diseases related to eosinophilia

Clinical Features for Eosinophilia

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Drugs & Therapeutics for Eosinophilia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Eosinophilia

Drug clinical trials:

Search ClinicalTrials for Eosinophilia

Search NIH Clinical Center for Eosinophilia

Search CenterWatch for Eosinophilia

Genetic Tests for Eosinophilia

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Anatomical Context for Eosinophilia

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32MalaCards
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MalaCards organs/tissues related to Eosinophilia:

32
Lung, T cells, Myeloid, Skin, Bone, Thyroid, Bone marrow, Testes, Liver, Heart, B cells, Monocytes, Endothelial, Brain, Colon, Whole blood, Kidney, Salivary gland, Lymph node, Prostate, Breast, Skeletal muscle, Thymus, Eye, Spinal cord, Ovary, Nk cells

Animal Models for Eosinophilia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eosinophilia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538711.0IL8, CCL11, CCL17, CCR3, CCL7, IFNG
2MP:000539710.7CCL11, CCR3, CCL7, IFNG, PDGFRB, PRG2
3MP:000538810.6CYSLTR1, PRG2, CCL11

Publications for Eosinophilia

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50PubMed
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Articles related to Eosinophilia:

(show top 50)    (show all 1628)
idTitleAuthorsYear
1
Adrenocortical tumours: high CT attenuation value correlates with eosinophilia but does not discriminate lipid-poor adenomas from malignancy. (23908452)
2013
2
Predicting sputum eosinophilia in exacerbations of COPD using exhaled nitric oxide. (23681903)
2013
3
Severe eosinophilia in children: a diagnostic dilemma. (23612381)
2013
4
Tropical pulmonary eosinophilia--a review. (24135173)
2013
5
An observational study on peripheral blood eosinophilia in incomplete Kawasaki disease. (22306569)
2012
6
Angiolymphoid hyperplasia with eosinophilia and Kimura's disease coexisting in the same patient: evidence for a spectrum of disease. (22881472)
2012
7
Increased numbers of eosinophils, rather than only etiology, predict histologic changes in patients with esophageal eosinophilia. (22289868)
2012
8
Eosinophilia, regardless of degree, is related to better outcomes after allogeneic hematopoietic stem cell transplantation. (22504238)
2012
9
Lung nodules, fever, and eosinophilia in a traveler returning from Madagascar. (22232438)
2012
10
Clinical characteristics and long-term outcomes related to sputum eosinophilia in Korean asthmatics. (22053292)
2011
11
Angiolymphoid hyperplasia with eosinophilia on penile skin in a 7-year-old child. (21376210)
2011
12
Drug rash, eosinophilia, and systemic symptoms syndrome: Two pediatric cases demonstrating the range of severity in presentation--A case of vancomycin-induced drug hypersensitivity mimicking toxic shock syndrome and a milder case induced by minocycline. (20407399)
2010
13
Drug reaction with eosinophilia and systemic symptoms: a retrospective study of 60 cases. (20713773)
2010
14
Piperacillin-associated pulmonary infiltrates with eosinophilia: a case report. (20422064)
2010
15
Eosinophilia as a predictor of food allergy in atopic dermatitis. (20406588)
2010
16
Eosinophilia and multifocal vertebral involvement with Hodgkin lymphoma. (20658631)
2010
17
Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome. (19733945)
2009
18
Non-small-cell lung cancer associated with excessive eosinophilia and secretion of interleukin-5 as a paraneoplastic syndrome. (17160990)
2007
19
Severe combined immunodeficiency signalized by eosinophilia and lymphopenia in rotavirus infected infants. (18050045)
2007
20
The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. (16373672)
2006
21
Comparative proteomic analysis of peripheral blood eosinophils from healthy donors and atopic dermatitis patients with eosinophilia. (15832365)
2005
22
A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. (12750406)
2003
23
Transgenic overexpression of human IL-17E results in eosinophilia, B- lymphocyte hyperplasia, and altered antibody production. (12239140)
2002
24
Chronic eosinophilic leukaemia presenting with erythroderma, mild eosinophilia and hyper-IgE: clinical, immunological and cytogenetic features and therapeutic approach. A case report. (11919392)
2002
25
Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. (10606395)
1999
26
C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). (10491000)
1999
27
Eotaxin contributes to renal interstitial eosinophilia. (10052481)
1999
28
Evaluation of blood eosinophilia and the eosinophil cationic protein (ECP) in the serum of asthmatic children with varying degree of severity. (10611555)
1999
29
Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. (9103460)
1997
30
Pathogenetic factors of acute schistosomiasis mansoni: correlation of worm burden, IgE, blood eosinophilia and intensity of clinical manifestations. (8665387)
1996
31
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
32
Inhibition of antigen-induced pulmonary eosinophilia and neutrophilia by selective inhibitors of phosphodiesterase types 3 or 4 in Brown Norway rats. (8820246)
1995
33
Continuing occurrence of eosinophilia myalgia syndrome in Canada. (7728400)
1995
34
The eosinophilia-myalgia syndrome: status of 205 patients and results of treatment 2 years after onset. (7741371)
1995
35
Eosinophilia-myalgia syndrome not associated with the ingestion of nutritional supplements. (7699648)
1994
36
Eosinophilia-myalgia syndrome and fasciitis with an active alveolitis. (8355447)
1993
37
Intratracheal application of Sephadex in rats leads to massive pulmonary eosinophilia without bronchial hyperreactivity to acetylcholine. (1382750)
1992
38
Eosinophilia-myalgia syndrome. (2027503)
1991
39
Papular mucinosis in L-tryptophan-induced eosinophilia-myalgia syndrome. (1880255)
1991
40
Eosinophilia-myalgia syndrome with myoclonic jerks. (2292676)
1990
41
Eosinophilia-myalgia syndrome and L-tryptophan-containing products--New Mexico, Minnesota, Oregon, and New York, 1989. (2509891)
1989
42
Pathologic quiz case 1. Epithelioid hemangioma (histiocytoid hemangioma, angiolymphoid hyperplasia with eosinophilia). (3814384)
1987
43
Trisomy 22--a new abnormality found in acute leukemia characterized by eosinophilia and monocytoid blasts expressing immature differentiation antigens. (3463400)
1986
44
Recurrent granulomatous dermatitis with eosinophilia. Wells' syndrome. (6724778)
1984
45
Presence of eosinophilia in progressive systemic sclerosis and localized scleroderma. (7332350)
1981
46
Thyroid eosinophilia and cutaneous Arthus reaction simultaneously induced in the guinea-pig by antiserum to thyroglobulin. (4249611)
1970
47
Bronchitis as a sequel of tropical pulmonary eosinophilia. (5520224)
1970
48
Acute adrenal insufficiency and acute myocardial infarction; simultaneous occurrence associated with marked eosinophilia and recovery. (13322213)
1956
49
Tropical pulmonary eosinophilia. (14809749)
1950
50
Pulmonary eosinophilia; a preliminary report on 15 cases of tropical eosinophilic asthma. (15411430)
1950

Genetic Variations for Eosinophilia

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Expression for genes affiliated with Eosinophilia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilia

Search GEO for disease gene expression data for Eosinophilia.

Pathways for genes affiliated with Eosinophilia

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51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Eosinophilia according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9IL8, IL4, IL5, IL3, IL13, PDGFRB
2
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10.9CCL17, CCR3, IL13, PDGFRB, CCL11, IL3
3
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10.8CCL11, PRG2, EPX, RNASE3, IFNG, IL13
4
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10.8IL13, PDGFRB, IL3, IL5, CCR3, CCL17
5
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10.8CCL17, CYSLTR1, PDGFRB, PDE4A, CCL7, CCR3
6
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10.8IL3, IGHE, IL13, IL4, CCL11, IFNG
710.7IFNG, IL8, IL4, IL5, IL3, IL13
8
Hide members
10.7PRG2, PDGFRB, CCL7, CCR3, IL5, CCL17
9
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10.7CCL7, CCL11, CCR3, CYSLTR1, IL8, CCL17
10
Hide members
10.7IL8, PRG2, CCL7, CCR3, CCL17, CCL11
1110.7IL4, IL5, IL3, IL13, IFNG
12
Hide members
10.7IL4, IL5, IL8, IL3, IFNG
1310.7IL4, IL5, IFNG, IL8, IL13
14
Hide members
10.7IL5, CCL11, IL13, CCL7, CCL17
1510.7IL4, CCL11, CCL17, IGHE, IL5
16
Hide members
10.7CCL11, CCR3, CCL7, IL8, CCL17
1710.7IL8, CCL7, CCL17, CCL11, CCR3
1810.6CCL11, IL4, IL8, IL5
1910.6IL4, IL13, IFNG, IL5
20
Hide members
10.6IL4, IL5, IL13, IFNG
21
Immune response CCR3 signaling in eosinophils
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10.6CCL11, CCR3, CCL7, IL8
2210.6IL4, IL5, IL3
2310.6IL4, IL5, IL13
2410.6IFNG, IL4, IL5
2510.6IL8, CCL11, IL4

Compounds for genes affiliated with Eosinophilia

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44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 2BitterDB
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Compounds related to Eosinophilia according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2413.5CCR3, CCL7, IFNG, PDE4A, PRG2, IGHE
2dexamethasone44 49 28 1114.5CCL17, CCL11, EPX, CYSLTR1, IL8, IL13
3leukotriene b444 59 2413.3CCL11, CCL7, PDE4A, EPX, CYSLTR1, RNASE3
4fmlp4411.3CCL11, CCL7, PDE4A, PRG2, EPX, RNASE3
5budesonide44 49 1113.3CCL11, IFNG, PDE4A, IGHE, EPX, RNASE3
6actinomycin d4411.3IL3, IL4, IL8, IFNG, CCL11, CCR3
7cyclosporin a44 28 5913.3IL4, IL8, IL5, IL3, IL13, RNASE3
8tarc4411.3CCL11, CCL17, CCR3, CCL7, IFNG, IGHE
9allergens4411.3CCL11, CCL17, IFNG, PRG2, IGHE, EPX
10pgd24411.3CCL11, CCR3, PRG2, IGHE, EPX, CYSLTR1
11salbutamol44 49 28 11 2415.3RNASE3, IL13, IL5, IL8, CYSLTR1, EPX
12fluticasone propionate44 49 59 1114.2IL8, IL4, IL5, CCL11, IFNG, IGHE
13tyrosine4411.2CCL7, PDE4A, CYSLTR1, PRG2, EPX, CCL11
14methacholine44 1112.2IL8, IL4, CCL11, PRG2, IGHE, RNASE3
15ltc44411.2IL5, IL3, IL13, CCL11, PRG2, EPX
16montelukast44 49 28 1114.2CCL11, IGHE, CYSLTR1, RNASE3, IL13, IL5
17salmeterol44 49 28 1114.2CCL11, PDE4A, EPX, RNASE3, IL13, IL5
18retinoic acid44 2412.2CCL11, PRG2, IL5, IFNG, PDE4A, PDGFRB
19genistein44 28 59 2 11 2416.1PRG2, IFNG, IL5, IL8, PDGFRB, CCL7
20il 104411.1IL5, IL4, IL13, IFNG, CCL17, IL8
21rantes4411.1IL3, CCL11, IL4, RNASE3, IFNG, CCL7
22ccl344 2812.1CCL11, CCL17, CCR3, CCL7, IFNG, IL13
23cetirizine44 28 11 2414.1RNASE3, EPX, IGHE, CCL11, IL5, IL8
24nedocromil sodium4411.1IL3, IGHE, RNASE3, IL5, IL4, IL8
25ketotifen44 1112.1RNASE3, EPX, IL5, IGHE, PDE4A, CCL11
26ltd44411.1CCR3, IL3, CYSLTR1, RNASE3, IL13, IL5
27heparin44 28 11 2414.1CCR3, PRG2, IL8, RNASE3, EPX, IL13
28prednisolone44 28 1113.0CCL11, IFNG, IGHE, EPX, RNASE3, IL13
29lte44411.0EPX, CCL11, CYSLTR1, RNASE3, IL5
30poly(i-c)4411.0CCL11, IFNG, IL5, IL4, IL8, IL3
31sodium cromoglycate4411.0IGHE, EPX, RNASE3, IL5, CCL11
32formoterol44 28 1113.0IL8, IL13, RNASE3, PDE4A, IL4
33pranlukast44 28 1113.0CYSLTR1, RNASE3, IL5, IL4, CCL11
34rolipram44 59 2813.0PDE4A, EPX
35pge24411.0EPX, PDE4A, CCL11, CYSLTR1
36praziquantel44 1112.0IGHE, IL4, IL5, IL13, RNASE3
37herbimycin a44 5912.0CCL11, CCR3, IL3, IL5, IL4, IL8
38azelastine44 1111.9IL4, IL5, IL3, IGHE, RNASE3
39vegf4410.9IL4, IL5, IL13, RNASE3, IGHE, PDGFRB
40indomethacin44 59 28 1113.9PRG2, IL5
41il-124410.9IL8, IL13, IFNG, IL4, IL5
42gm-csf44 2811.9IFNG
43hydrocortisone44 2 59 1113.8IGHE, IL8
44theophylline44 28 11 2413.8IL5, IL13, RNASE3, EPX, CYSLTR1, PDE4A
45unicap4410.8IGHE, RNASE3, IL5, CCL11
46omalizumab44 1111.8IGHE, IL13, IL5, IL4
47tacrolimus44 49 1112.8IL4, IL5, IL3, IL13, IFNG, CCL17
48anaphylatoxin4410.7CCL7, IL8, IL4, RNASE3, IL3
49ly2940024410.5CCL11, PDE4A, PDGFRB, IL13, IL3, IL8
50cycloheximide4410.4PDE4A

GO Terms for genes affiliated with Eosinophilia

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16Gene Ontology
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Cellular components related to Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.9CCL11, CCL17, IL5, IL3, IL13, RNASE3
2extracellular spaceGO:00561510.6CCL11, IL4, IL5, IL3, IL13, IFNG

Biological processes related to Eosinophilia according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.1IL5, IL4, IL3, CCL11, IL13, IGHE
2inflammatory responseGO:00695411.1CCR3, CCL17, CCL7, IL13, IL5, IL8
3chemotaxisGO:00693511.0CCL7, CCL11, CCL17, CCR3, CYSLTR1, IL4
4eosinophil chemotaxisGO:04824510.8CCL7, CCL11, CCR3
5positive regulation of B cell proliferationGO:03089010.8IL5, IL4, IL13
6regulation of proton transportGO:01015510.8IL13, IL4
7mast cell chemotaxisGO:00255110.7CCR3, CCL11
8positive regulation of isotype switching to IgG isotypesGO:04830410.7IFNG, IL4
9positive regulation of MHC class II biosynthetic processGO:04534810.7IFNG, IL4
10cell-cell signalingGO:00726710.6CCL17, CCL7, IL13, IL3
11positive regulation of chemokine biosynthetic processGO:04508010.6IFNG, IL4
12signal transductionGO:00716510.6IL8, IL13, PDGFRB, PDE4A, CCL7, CCL11
13cellular component movementGO:00692810.6IL8, IL13, IFNG
14positive regulation of angiogenesisGO:04576610.3CCR3, CCL11, CYSLTR1

Molecular functions related to Eosinophilia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7IL4, IL5, IL3, IL13, IFNG
2chemokine activityGO:00800910.3IL8, CCL7, CCL17, CCL11

Products for genes affiliated with Eosinophilia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eosinophilia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet