MCID: ESN007
MIFTS: 54

Eosinophilia malady

Genetic diseases, Immune diseases, Blood diseases, Rare diseases categories

Summaries for Eosinophilia

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Wikipedia:63 Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds 4.5 more...

MalaCards based summary: Eosinophilia, also known as disorder characterized by eosinophilia, is related to eosinophilia-myalgia syndrome and asthma. An important gene associated with Eosinophilia is PDGFRB (platelet-derived growth factor receptor, beta polypeptide), and among its related pathways are TSLP Signaling Pathway and Apoptosis Pathway. The compounds sodium cromoglycate and lte4 have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and myeloid, and related mouse phenotypes are endocrine/exocrine gland and digestive/alimentary.

Aliases & Classifications for Eosinophilia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 25ICD10
See all sources

Eosinophilia, Aliases & Descriptions:

Name: Eosinophilia 9 11 43 60
Disorder Characterized by Eosinophilia 60
Eosinophilic Leukocytosis 9
 
Eosinophil Count Raised 9
Eosinophilic Disorder 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology9 DOID:999
ICD9CM27 288.3
MeSH33 D004802
ICD1025 D72.1

Related Diseases for Eosinophilia

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Diseases in the Eosinophilia family:

Eosinophilia, Familial

Diseases related to Eosinophilia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 416)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia-myalgia syndrome32.4IL5
2asthma31.6CCL11, IL13
3eosinophilic fasciitis31.3IL5
4strongyloidiasis31.2IL5
5angioedema31.1IL5, RNASE3
6eosinophilic gastroenteritis30.9CCL11, IL5
7churg-strauss syndrome30.9RNASE3, IL5
8conjunctivitis30.9RNASE3
9esophagitis30.9CCR3, CCL11, IL5, IL13
10filariasis30.8IL13, IL5
11folliculitis30.7CCL11
12mastocytosis30.7PDGFRB, IL13, IL5
13kimura disease30.7RNASE3, IL5
14schistosomiasis30.6IL5, IL13
15hypereosinophilic syndrome30.6PDGFRB, IL5, CCL11, EPX, RNASE3
16omenn syndrome30.6IL4, IL5
17aspergillosis30.6IFNG
18allergic bronchopulmonary aspergillosis30.6IL4, IL5
19sinusitis30.6RNASE3, CCL11, IL5
20chronic eosinophilic pneumonia30.5RNASE3, CCL11, IL5
21chronic rhinitis30.5RNASE3
22pulmonary eosinophilia30.4EPX, CCR3, CCL11, IL4, IL5, IL8
23allergic rhinitis30.4RNASE3, IL4, IL5, IL13
24dermatitis30.4RNASE3, CCL17, IL4, IL13
25onchocerciasis30.3RNASE3, EPX, IL5
26malaria30.2IFNG
27paragonimiasis30.2CCL17, IL5
28egg allergy30.1IL4, IL5
29bronchitis30.1RNASE3, CCR3, CCL11, IL5, IL8
30mycosis fungoides30.1CCL17, CCR3, IL5
31hypereosinophilic syndrome, idiopathic, resistant to imatinib30.1IL5, IL3, PDGFRB
32leukemia30.1RNASE3, EPX, CCL11, IFNG, IL4, IL3
33keratoconjunctivitis30.1RNASE3, CCL11, IL5, IL13
34acute graft versus host disease30.1IL4, IFNG
35polycythemia vera30.0IL3, PDGFRB
36eosinophilic pneumonia30.0RNASE3, CCL17, CCL11, IL5, IL3, IL13
37intrinsic asthma30.0RNASE3, IL4, IL5
38interstitial lung disease29.9CCL17, CCL11, IL8
39pulmonary fibrosis29.9PDGFRB, IL13, IL8, CCL17
40pneumonia29.9EPX, CCL17, CCL11, IL5, IL8, IL13
41common cold29.9IL8, CCL11, RNASE3
42allergic conjunctivitis29.8IL5, IL4, CCL11, RNASE3, IL13
43hyper-ige recurrent infection syndrome29.8RNASE3, IFNG, IL4
44tuberculosis29.8EPX, IFNG, IL4
45uveitis29.8IL4, IFNG, CCL11
46atopic dermatitis29.8RNASE3, CCL17, CCR3, CCL11, IL4, IL13
47rhinitis29.8RNASE3, EPX, CCL11, IL4, IL5, IL8
48lymphopenia29.7IL4, IFNG
49bullous pemphigoid29.7RNASE3, CCL17, CCL11, IL5, IL13
50bronchiolitis29.6RNASE3, CCL11, IL5, IL8, IL13

Graphical network of the top 20 diseases related to Eosinophilia:



Diseases related to eosinophilia

Symptoms for Eosinophilia

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Drugs & Therapeutics for Eosinophilia

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Drug clinical trials:

Search ClinicalTrials for Eosinophilia

Search NIH Clinical Center for Eosinophilia

Genetic Tests for Eosinophilia

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Anatomical Context for Eosinophilia

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MalaCards organs/tissues related to Eosinophilia:

31
Lung, T cells, Myeloid, Skin, Bone, Thyroid, Bone marrow, Liver, Testes, Heart, B cells, Brain, Colon, Monocytes, Endothelial, Whole blood, Lymph node, Kidney, Salivary gland, Neutrophil, Eye, Thymus, Spinal cord, Skeletal muscle, Breast, Ovary, Prostate, Nk cells, Tongue

Animal Models for Eosinophilia or affiliated genes

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MGI Mouse Phenotypes related to Eosinophilia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.0PDGFRB, IL13, IL3, IL4, IFNG
2MP:00053818.0IFNG, IL4, IL5, IL13, PDGFRB
3MP:00053887.4CCR3, CCL11, IFNG, IL4, IL5, IL3
4MP:00053847.1CCL17, CCR3, IFNG, IL4, IL3, IL13
5MP:00053767.1CCR3, IFNG, IL4, IL5, IL3, IL13
6MP:00053975.7PDGFRB, EPX, CCL17, CCR3, CCL11, IFNG
7MP:00053875.7CCL11, CCR3, CCL17, EPX, IFNG, IL4

Publications for Eosinophilia

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Articles related to Eosinophilia:

(show top 50)    (show all 1691)
idTitleAuthorsYear
1
Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported. (25754017)
2015
2
Eosinophilia induced by clozapine: a report of two cases and review of the literature. (25811003)
2015
3
Acute lymphoblastic leukemia with eosinophilia lacking peripheral blood leukemic cell: a rare entity. (25332543)
2014
4
Gene-Gene Interaction Between CCR3 and Eotaxin Genes: The Relationship With Blood Eosinophilia in Asthma. (24404394)
2014
5
Letter: PPI-responsive oesophageal eosinophilia - from initial skepticism to consistent prospective data; authors' reply. (24330242)
2014
6
Changes in blood eosinophilia during omalizumab therapy as a predictor of asthma exacerbation. (25395927)
2014
7
Angiolymphoid hyperplasia with eosinophilia with follicular mucinosis. (23716828)
2013
8
Increased FDG Uptake of the Bone Marrow Mimicking Malignancy in a Patient of Eosinophilia Secondary to Sparganum mansoni Infection. (23877523)
2013
9
Natural history of severe eosinophilia with uncertain aetiology and proposals on a practical approach to its management. (22151137)
2012
10
Case of angiolymphoid hyperplasia with eosinophilia associated with scabies infestation. (21950730)
2012
11
Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitis. (22134787)
2012
12
The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia. (22190185)
2012
13
IL-5 receptor I+ levels in patients with marked eosinophilia or mastocytosis. (21762978)
2011
14
Peripheral eosinophilia camouflaging anaplastic large cell lymphoma. (18805872)
2011
15
Allopurinol causing drug rash with eosinophilia and systemic symptoms syndrome: a challenging diagnosis. (22162933)
2011
16
Long-term outcomes in pediatric-onset esophageal eosinophilia. (21636117)
2011
17
Cerebrospinal fluid eosinophilia associated with intraventricular shunts. (21492998)
2011
18
Drug-induced lymphadenopathy with eosinophilia and renal failure mimicking lymphoma disease: dramatic onset of DRESS syndrome associated with antibiotic treatment. (21298267)
2011
19
Drug rash, eosinophilia, and systemic symptoms syndrome: Two pediatric cases demonstrating the range of severity in presentation--A case of vancomycin-induced drug hypersensitivity mimicking toxic shock syndrome and a milder case induced by minocycline. (20407399)
2010
20
The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. (16373672)
2006
21
Angiolymphoid hyperplasia with eosinophilia masquerading as Kimura disease. (15888362)
2005
22
Decreased levels of CXCR3 transcripts in peripheral blood mononuclear cells from patients with atopic dermatitis and with cutaneous diseases associated with eosinophilia. (11480592)
2001
23
The association of skin test reactivity, total serum IgE levels, and peripheral blood eosinophilia with asthma in Kuwait. (11011754)
2000
24
Differential susceptibility of C57BL/6 and DBA/2 mice to ovalbumin-induced pulmonary eosinophilia regulated by Th1/Th2-type cytokines. (10569702)
1999
25
Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. (9034156)
1997
26
Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. (8784786)
1996
27
The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4. (8818342)
1996
28
The eosinophilia-myalgia syndrome and the toxic oil syndrome. Pursuing parallels. (8906286)
1996
29
1,1'-Ethylidenebis[L-tryptophan], an impurity in L-tryptophan associated with eosinophilia-myalgia syndrome, stimulates type I collagen gene expression in human fibroblasts in vitro. (8624499)
1995
30
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
31
P-31 magnetic resonance spectroscopy of skeletal muscle in the eosinophilia-myalgia syndrome: a preliminary study. (8035389)
1994
32
Adrenal function & the pattern of glucocorticoid induced eosinopenia in tropical pulmonary eosinophilia. (8225446)
1993
33
Unusual widespread type of angiolymphoid hyperplasia with eosinophilia mimicking prurigo nodularis. (8277047)
1993
34
The eosinophilia-myalgia syndrome: current concepts and future directions. (1551286)
1992
35
Production of granulocyte-macrophage colony-stimulating factor in two patients with lung cancer, leukocytosis, and eosinophilia. (1540871)
1992
36
Eosinophilia in murine ancylostomiasis. (1512453)
1992
37
Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels. The Normative Aging Study. (1928948)
1991
38
Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis. (1918387)
1991
39
Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1929872)
1991
40
Electrocardiographic abnormalities in tropical pulmonary eosinophilia. (2148545)
1990
41
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
42
Elevated serum IgE, eosinophilia, and lung function in rubber workers. (2317085)
1990
43
Frequency, levels, and significance of blood eosinophilia in systemic sclerosis, localized scleroderma, and eosinophilic fasciitis. (3668010)
1987
44
Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization. (6221046)
1982
45
Clinical studies in pulmonary eosinophilia. II--Relation of blood eosinophilia and pulmonary manifestations in clinic patients and urban population. (721166)
1978
46
Adrenaline and tropical pulmonary eosinophilia. (1248889)
1976
47
Drug-induced lung disease: pulmonary eosinophilia and sulphonamides. (1236549)
1975
48
Studies on eosinophilia in parasitic diseases and pellagra. (13755660)
1960
49
The significance of conjunctival eosinophilia in the diagnosis of allergic conjunctivitis. (14896900)
1951
50
Pulmonary eosinophilia (tropical eosinophilia). (18152220)
1949

Variations for Eosinophilia

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Expression for genes affiliated with Eosinophilia

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Search GEO for disease gene expression data for Eosinophilia.

Pathways for genes affiliated with Eosinophilia

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Pathways related to Eosinophilia according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL8, CCL11
2
Show member pathways
9.5PDGFRB, IL13, IL5
39.3IL3, IL5, IL4
49.2IL13, IL5, IL4
59.2IFNG, IL13
6
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.1IL4, IFNG
7
Show member pathways
9.1IL8, CCL11, CCR3
89.0IFNG, IL8
9
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.8IL5, IL4, IFNG
108.8IL5, IL4, IFNG
11
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
8.8IL4, IL5, IL3, IL13
128.8CCL17, CCL11, IL4, IL5
13
Show member pathways
Immune response CD16 signaling in NK cells58
8.8IFNG, IL4, IL3
148.7IL8, IL3, IFNG
15
Show member pathways
8.6CCL17, CCR3, CCL11, IL8
16
Show member pathways
8.6CCL17, CCR3, CCL11, IL8
17
Show member pathways
8.6CCL17, CCR3, CCL11, IL8
18
Show member pathways
8.6IL8, CCL11, CCR3, CCL17
198.5IFNG, IL4, IL8
208.4IL13, IL5, IL4, IFNG
21
Show member pathways
8.4IFNG, IL4, IL5, IL13
228.4IFNG, IL4, IL5, IL13
23
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.2CCL11, IFNG, IL4, IL8
24
Show member pathways
8.1IFNG, IL4, IL8, IL13
25
Show member pathways
Type III interferon signaling36
8.0IFNG, IL4, IL5, IL3, IL13
26
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
7.9IFNG, IL4, IL5, IL3, IL8
277.8IL13, IL8, IL5, IL4, IFNG
287.4IFNG, IL4, IL5, IL3, IL8, IL13
29
Show member pathways
7.1RNASE3, EPX, CCL11, IFNG, IL4, IL5
30
Show member pathways
6.7CCL17, PDGFRB, IL13, IL8, IL3, IL5
31
Show member pathways
6.7IL13, IL8, IL3, IL5, IL4, CCL11
32
Show member pathways
6.7CCL17, CCR3, CCL11, IL4, IL5, IL3
33
Show member pathways
6.3CCL17, CCL11, IFNG, IL4, IL5, IL3
34
Show member pathways
5.9PDGFRB, CCL17, CCR3, CCL11, IFNG, IL4

Compounds for genes affiliated with Eosinophilia

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Compounds related to Eosinophilia according to GeneCards Suite gene sharing:

(show top 50)    (show all 164)
idCompoundScoreTop Affiliating Genes
1sodium cromoglycate439.5RNASE3, CCL11, IL5, EPX
2lte4439.5RNASE3, EPX, CCL11, IL5
3pranlukast43 28 1211.2IL5, IL4, RNASE3, CCL11
4ltd4439.0CCR3, IL5, IL3, IL13, RNASE3
5cetirizine43 28 24 1212.0RNASE3, EPX, CCL11, IL5, IL8
6roxithromycin43 28 1211.0CCL17, CCL11, IL5, IL8
7ketotifen43 129.9RNASE3, IL5, CCL11, EPX
8praziquantel43 129.9RNASE3, IL13, IL5, IL4
9formoterol43 28 1210.8IL13, IL4, IL8, RNASE3
10ltc4438.8IL13, IL3, IL5, CCL11, EPX, RNASE3
11n-formylmethionyl-leucylphenylalanine438.8IL3, IL8, RNASE3, CCL11, IL5
12nedocromil sodium438.8RNASE3, IL4, IL5, IL8, IL3
13pgd2438.8CCL11, IL13, IL5, CCR3, EPX, RNASE3
14mip 1alpha438.7IL3, IL8, IL13, IL4
15salbutamol43 49 28 24 1212.6IL13, RNASE3, EPX, CCL11, IL5, IL8
16glatiramer acetate43 129.5IL13, IL5, IFNG, IL4
17montelukast43 49 28 1211.4RNASE3, CCL11, IL4, IL5, IL8, IL13
18amphotericin b438.4IFNG, IL5, IL13, IL4
19methacholine43 49 1210.4CCL11, IL4, IL13, RNASE3, IL8, IL5
20prednisolone43 28 1210.3IFNG, CCL11, RNASE3, EPX, IL5, IL13
21leukotriene b443 59 2410.2EPX, RNASE3, IL3, CCL11, IL5, IL8
22fmlp438.2IL3, CCL11, IL8, EPX, IL13, IL5
23il-12438.1IL8, IL5, IL4, IFNG, IL13
24salmeterol43 49 28 1211.1RNASE3, IL13, IL8, IL5, IL4, CCL11
25ly294002438.0IL3, PDGFRB, IL13, IL4, CCL11, IL5
26ionomycin438.0IL5, IL4, CCL11, IFNG, IL3, IL13
27poly(i-c)437.9IL4, IL8, IL3, CCL11, IFNG, IL5
28gm-csf43 288.8IL13, IL8, IL3, IL5, IL4, IFNG
29hydrocortisone43 2 59 1210.7IL4, IFNG, IL5, IL13, IL3, IL8
30heparin43 28 24 1210.7CCR3, EPX, CCL11, IL13, IL8, IL5
31ccl343 288.7CCL17, IL8, CCR3, CCL11, IFNG, IL13
32butyrate437.6EPX, IL5, IFNG, CCL11, IL3, IL8
33genistein43 28 59 2 24 1212.6IL5, PDGFRB, IL8, CCL11, CCR3, IFNG
34fluticasone propionate43 49 59 1210.6RNASE3, CCL11, IFNG, IL4, IL5, IL8
35tacrolimus43 49 129.5IL13, IL3, CCL17, CCL11, IFNG, IL4
36rolipram43 59 289.5IL13, IL8, IL5, IL4, IFNG, CCL11
37herbimycin a43 598.5IL5, IL3, IL8, CCL11, CCR3, IL4
38allergens437.4IL4, IL5, IL13, IFNG, CCL11, RNASE3
39il 10437.3IL13, IL8, IL3, IL5, CCL17, IFNG
40budesonide43 49 129.2CCL11, RNASE3, EPX, IFNG, IL4, IL5
41actinomycin d437.2IL13, IL8, IL3, IL4, IFNG, CCR3
42thymidine43 248.2IL4, IL5, IL3, IFNG, CCR3, IL13
43pge2437.2IL13, RNASE3, EPX, IFNG, IL4, IL5
44vegf437.1CCL11, IL4, IL5, IL8, RNASE3, IFNG
45tarc437.0IFNG, CCR3, CCL17, CCL11, IL4, IL5
46cysteine436.7IL13, IL8, IL5, IL4, CCR3, IL3
47cyclosporin a43 28 598.7IL5, CCL11, IL4, CCL17, RNASE3, IL3
48histamine43 28 248.5IL13, IL8, CCL11, IFNG, IL4, IL5
49rantes436.3CCL17, CCL11, IFNG, IL4, IL5, IL3
50dexamethasone43 49 28 128.9CCL17, EPX, RNASE3, CCR3, CCL11, IL8

GO Terms for genes affiliated with Eosinophilia

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Cellular components related to Eosinophilia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.7IL13, IL4, IFNG
2extracellular regionGO:00055766.5RNASE3, CCL17, CCL11, IFNG, IL5, IL3
3extracellular spaceGO:00056156.5IL13, CCL17, CCL11, IFNG, IL4, IL5

Biological processes related to Eosinophilia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of smooth muscle cell proliferationGO:00486619.8PDGFRB, IL13
2regulation of proton transportGO:00101559.7IL4, IL13
3positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.6IL4, IL3
4positive regulation of B cell proliferationGO:00308909.5IL13, IL5, IL4
5positive regulation of isotype switching to IgG isotypesGO:00483049.3IL4, IFNG
6positive regulation of MHC class II biosynthetic processGO:00453489.3IL4, IFNG
7positive regulation of chemokine biosynthetic processGO:00450809.3IFNG, IL4
8defense response to protozoanGO:00428329.2IFNG, IL4
9cell-cell signalingGO:00072679.0IL13, IL3, CCL17
10neutrophil chemotaxisGO:00305938.7IL8, IFNG
11cellular component movementGO:00069288.7IL13, IL8, IFNG
12chemotaxisGO:00069358.3CCL17, CCR3, CCL11, IL4, IL8
13inflammatory responseGO:00069548.1CCL17, CCR3, CCL11, IL5, IL8, IL13
14immune responseGO:00069557.7IL13, IL8, IL3, IL5, IL4, CCL11

Molecular functions related to Eosinophilia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.3IL3, IL5, IL4
2chemokine activityGO:00080098.7CCL17, CCL11, IL8
3cytokine activityGO:00051257.9IL13, IL3, IL5, IL4, IFNG

Products for genes affiliated with Eosinophilia

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Sources for Eosinophilia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet