MCID: ESN002
MIFTS: 41

Eosinophilia-Myalgia Syndrome malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

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Aliases & Descriptions for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 11 47 49 38 13 67
Ems 47 2
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 47
 
Severe Muscle Pain and Abnormally High Eosinophils 47
Eosinophilia Myalgia Syndrome 11
L-Tryptophan Induced Ems 47

Classifications:



External Ids:

Disease Ontology11 DOID:998
ICD9CM31 710.5
SNOMED-CT61 95416007
MeSH38 D016603

Summaries for Eosinophilia-Myalgia Syndrome

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CDC:2 Emergency medical services (EMS) workers provide pre-hospital emergency medical care. Their duties create an inherent risk for on-the-job injuries and illnesses. Research shows that EMS workers have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary: Eosinophilia-Myalgia Syndrome, also known as ems, is related to fibrous histiocytoma and eosinophilia, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways are Th2 Differentiation Pathway and Inflammatory Response Pathway. Affiliated tissues include skin, heart and lung.

Wikipedia:70 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

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Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 120)
idRelated DiseaseScoreTop Affiliating Genes
1fibrous histiocytoma29.7HLA-DRB1, IFNG
2eosinophilia11.1
3toxic oil syndrome10.5
4fasciitis10.5
5cholesteatoma of middle ear10.4IFNG, IL5
6thomsen and becker disease10.4IFNG, IL5
7gonococcal synovitis10.4IFNG, IL5
8acute gonococcal salpingitis10.4IFNG, IL5
9opiate dependence10.4IFNG, IL5
10cervix melanoma10.4IFNG, IL5
11idiopathic neutropenia10.4IFNG, IL5
12buphthalmos10.4IFNG, IL5
13tetanus neonatorum10.3IFNG, IL5
14granulomatous endometritis10.3IDO1, IL5
15x-linked intellectual disability, siderius type10.3IFNG, IL5
16sarcoid meningitis10.3IFNG, IL5
17compensatory emphysema10.3HLA-DQA1, IFNG
18eosinophilic fasciitis10.3
19wissler's syndrome10.3IFNG, IL5
20dengue disease10.3IFNG, IL5
21intrinsic cardiomyopathy10.3HLA-DQA1, IFNG
22gastric ulcer10.3IFNG, IL5
23churg-strauss syndrome10.3IFNG, IL5
24exophthalmos10.3IFNG, IL5
25conventional malignant hemangiopericytoma10.3IFNG, IL5
26blind hypotensive eye10.3IFNG, IL5
27liver carcinoma in situ10.3IDO1, IFNG
28calcifying epithelial odontogenic tumor10.3IDO1, IFNG
29psychologic dyspareunia10.2IDO1, IFNG
30lung sarcoma10.2IFNG, IL5
31alternating exotropia10.2IFNG, IL5
32arcus senilis10.2IFNG, IL5
33uterine corpus dissecting leiomyoma10.2IFNG, IL5
34deafness, autosomal recessive 6210.2IFNG, IL5
35bolivian hemorrhagic fever10.1HNMT, IFNG
36polyneuropathy10.1
37motion sickness10.1IFNG, IL5
38giant ganglionic hyperplasia10.1HLA-DRB1, IL5
39myopathy10.1
40neuropathy10.1
41purpura fulminans10.1HLA-DRB1, IL5
42wolffian duct adenocarcinoma10.1HLA-DQA1, HLA-DRB1
43parsonage turner syndrome10.1HLA-DQA1, HLA-DRB1
44myopathy-growth delay-intellectual disability-hypospadias syndrome10.1HLA-DQA1, HLA-DRB1
45ovarian papillary cystadenoma10.1HLA-DQA1, HLA-DRB1
46panuveitis10.0HLA-DQA1, HLA-DRB1
47autoinflammation, lipodystrophy, and dermatosis syndrome10.0HLA-DQA1, HLA-DRB1
48oculogyric crisis10.0HLA-DQA1, HLA-DRB1
49anthracosilicosis10.0HLA-DRB1, IFNG
50lymphocytic colitis10.0HLA-DRB1, IFNG

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Symptoms for Eosinophilia-Myalgia Syndrome

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UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


muscle cramp, muscle rigidity, muscle spasticity, pain, muscle weakness, myalgia

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

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Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
15-hydroxytryptophan13
2TryptophanNutraceutical62

Interventional clinical trials:

idNameStatusNCT IDPhase
1L-5-HTP-Related EMSCompletedNCT00001918
2Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical TrialsCompletedNCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome


Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

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Anatomical Context for Eosinophilia-Myalgia Syndrome

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MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

35
Skin, Heart, Lung, Brain, T cells, Neutrophil, Liver

Animal Models for Eosinophilia-Myalgia Syndrome or affiliated genes

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Publications for Eosinophilia-Myalgia Syndrome

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Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 338)
idTitleAuthorsYear
1
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? (19941898)
2010
2
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. (17806156)
2007
3
Is there any relationship between eosinophilia myalgia syndrome (EMS) and fibromyalgia syndrome (FMS)? An analysis of clinical and immunological data. (10721092)
1999
4
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome. (9817085)
1998
5
Eosinophilia myalgia syndrome. (9213377)
1997
6
Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. (8895184)
1996
7
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
8
Eosinophilia-myalgia syndrome: a long-term follow-up study. (7660215)
1995
9
Psychiatric aspects of the eosinophilia-myalgia syndrome. (7871130)
1995
10
Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome. (7955801)
1994
11
The eosinophilia-myalgia syndrome: lessons from Germany. (8015338)
1994
12
Eosinophilia myalgia syndrome: absence of immunoglobulin reactivity suggests a cellular rather than humoral mechanism. (7976226)
1994
13
A murine model of the eosinophilia-myalgia syndrome induced by 1,1'-ethylidenebis (L-tryptophan). (8163652)
1994
14
Toxic oil syndrome and eosinophilia myalgia syndrome: similar, different or the same disorder? (7699614)
1994
15
Production of polyclonal antibodies against 1,1'-ethyliden bis[L-tryptophan] (EBT), a potential contaminant causing eosinophilia-myalgia syndrome (EMS). (8475503)
1993
16
Eosinophilia-myalgia syndrome and fasciitis with an active alveolitis. (8355447)
1993
17
Eosinophilia-myalgia syndrome: morbidity and mortality. (8295172)
1993
18
3-(Phenylamino)alanine--a link between eosinophilia-myalgia syndrome and toxic oil syndrome? (8423703)
1993
19
Use of cyclosporin A in the eosinophilia myalgia syndrome. (8427523)
1993
20
Identification of decomposition products of 1,1'-ethylidenebis [L-tryptophan], a compound associated with eosinophilia-myalgia syndrome. (1504513)
1992
21
Episodic angioedema with eosinophilia versus eosinophilia-myalgia syndrome. (1583248)
1992
22
Chronic demyelinating polyneuropathy associated with eosinophilia-myalgia syndrome. (1534836)
1992
23
Eosinophilia-myalgia syndrome: the aftermath. (1523446)
1992
24
Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome. (1418026)
1992
25
3-(Phenylamino)alanine, a novel aniline-derived amino acid associated with the eosinophilia-myalgia syndrome: a link to the toxic oil syndrome? (1469924)
1992
26
Eosinophilia-myalgia syndrome in L-tryptophan-exposed patients. (1727200)
1992
27
Serum cytokines and the eosinophilia myalgia syndrome. (1463513)
1992
28
Gastrointestinal involvement in L-tryptophan (L-Trp) associated eosinophilia-myalgia syndrome (EMS). (1563309)
1992
29
Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1929872)
1991
30
Environmental pathology. Mast cell and eosinophil infiltration in intestinal mucosa of Lewis rats treated with L-tryptophan implicated in human eosinophilia myalgia syndrome. (2068062)
1991
31
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (1984598)
1991
32
L-tryptophan-induced eosinophilia-myalgia syndrome. (1829754)
1991
33
Eosinophilia-myalgia syndrome. A clinical case series of 21 patients. New Mexico Eosinophilia-Myalgia Syndrome Study Group. (2001136)
1991
34
Effect of synthesized constituents in the L-tryptophan product on the differentiation of eosinophils and the induction of IL-6: a possible cause of eosinophilia-myalgia syndrome. (1872826)
1991
35
Eosinophilia-myalgia syndrome. (2027503)
1991
36
L-tryptophan-induced eosinophilia-myalgia syndrome. II. Partial correction of abnormal tryptophan metabolism by pyridoxine. (1722762)
1991
37
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
38
The eosinophilia-myalgia syndrome. (2339858)
1990
39
Eosinophilia-myalgia syndrome: unresolved questions. (2372919)
1990
40
Peripheral neuropathy in the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. (2162498)
1990
41
L-tryptophan induced eosinophilia-myalgia syndrome. (2273498)
1990
42
The eosinophilia-myalgia syndrome with neuritis associated with L-tryptophan use. (2339856)
1990
43
From the Centers for Disease Control. Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States, as of January 9, 1990. (2296113)
1990
44
Tryptophan and eosinophilia myalgia syndrome. (2244397)
1990
45
Eosinophilia-myalgia syndrome--Canada. (2282665)
1990
46
From the Centers for Disease Control. Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome. (2169007)
1990
47
Eosinophilia myalgia syndrome. (2385394)
1990
48
Eosinophilia-myalgia syndrome--New Mexico. (2509886)
1989
49
Eosinophilia-myalgia syndrome and L-tryptophan-containing products--New Mexico, Minnesota, Oregon, and New York, 1989. (2509891)
1989
50
Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States. (2511412)
1989

Variations for Eosinophilia-Myalgia Syndrome

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Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

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Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

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GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

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Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.6HLA-DQA1, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.6HLA-DQA1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125079.4HLA-DQA1, HLA-DRB1
4clathrin-coated endocytic vesicle membraneGO:00306699.4HLA-DQA1, HLA-DRB1
5endocytic vesicle membraneGO:00306669.2HLA-DQA1, HLA-DRB1
6transport vesicle membraneGO:00306589.1HLA-DQA1, HLA-DRB1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:00327359.7IDO1, IFNG
2interferon-gamma-mediated signaling pathwayGO:00603338.9HLA-DQA1, HLA-DRB1, IFNG
3T cell receptor signaling pathwayGO:00508528.8HLA-DQA1, HLA-DRB1, IFNG

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.2HLA-DQA1, HLA-DRB1

Sources for Eosinophilia-Myalgia Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet