Eosinophilia-myalgia Syndrome malady

Wikipedia: Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological...⁴⁴ more...

MalaCards: Eosinophilia-myalgia Syndrome, also known as syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart, is related to eosinophilia and breast cancer. An important gene associated with Eosinophilia-myalgia Syndrome is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are OX40 Pathway and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds toluene diisocyanate and n-formylkynurenine have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and lung, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Aliases & Descriptions:

eosinophilia-myalgia syndrome 6 30 8 32 43 syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart 30 severe muscle pain and abnormally high eosinophils 30

eosinophilia myalgia syndrome 6 l-tryptophan induced ems 30 ems 30

Diseases related to eosinophilia-myalgia syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 201)

id	Related Disease	Score	Top Affiliating Genes
1	eosinophilia	29.3	HNMT, CRH, TYRP1, IL5, IFNG, SCXA
2	breast cancer	26.7	IFNG, TDO2, TGFB1, TYRP1, CRH, HNMT
3	sinusitis	24.8	IFNG, IL5, CRH, TGFB1
4	ovarian cancer	24.8	CRH, HNMT, IDO1, IFNG, IL5, TGFB1
5	encephalomyelitis	24.1	IFNG, IL5, IDO1, CRH, TGFB1
6	systemic lupus erythematosus	23.9	IFNG, CRH, TGFB1, IL5, IDO1
7	hepatitis b	23.8	IFNG, TDO2, TGFB1, HNMT, IL5, IDO1
8	lupus erythematosus	23.8	IFNG, TGFB1, CRH, IDO1, IL5
9	multiple sclerosis	23.5	IDO1, IFNG, IL5, HNMT, CRH, TGFB1
10	obesity	23.4	IL5, IFNG, IDO1, TYRP1, CRH, TGFB1
11	alzheimer's disease	22.9	TGFB1, CRH, IDO1, TYRP1, HNMT, IFNG
12	hepatitis	22.8	HNMT, IDO1, TDO2, CRH, IFNG, IL5
13	endomyocardial fibrosis	13.3	SCXB, SCXA
14	status asthmaticus	13.1	IL5, TGFB1
15	ocular cicatricial pemphigoid	13.1	IL5, TGFB1
16	eosinophilic fasciitis	12.9	IL5, IFNG
17	paranasal sinus disease	12.9	IFNG, IL5
18	egg allergy	12.8	IL5, IFNG
19	cutaneous leishmaniasis	12.8	IFNG, IL5
20	urinary schistosomiasis	12.8	IFNG, IL5
21	scleritis	12.8	IL5, IFNG
22	allergic bronchopulmonary aspergillosis	12.8	IL5, IFNG
23	allergic conjunctivitis	12.8	IFNG, IL5
24	omenn syndrome	12.7	IL5, IFNG
25	pulmonary eosinophilia	12.7	IFNG, IL5
26	sezary's disease	12.7	IL5, IFNG
27	ascariasis	12.7	IDO1, IL5
28	cluttering	12.6	IFNG, TGFB1
29	opportunistic bacterial infectious disease	12.6	IDO1, IFNG
30	cystic lymphangioma	12.6	TGFB1, IFNG
31	cytomegalovirus retinitis	12.6	IFNG, IDO1
32	listeriosis	12.6	IDO1, IFNG
33	usual interstitial pneumonia	12.6	TGFB1, IFNG
34	alcoholism	12.6	CRH, HNMT, TDO2
35	nonspecific interstitial pneumonia	12.6	IFNG, TGFB1
36	subacute thyroiditis	12.5	TGFB1, IFNG
37	eosinophilic esophagitis	12.5	IFNG, IL5
38	lymphangioma	12.5	TGFB1, IFNG
39	strongyloidiasis	12.4	IFNG, TGFB1, IL5
40	spotted fever	12.4	IFNG, IDO1
41	cicatricial pemphigoid	12.4	IL5, IFNG, TGFB1
42	pleurisy	12.4	TGFB1, IFNG, IL5
43	serous glue ear	12.4	IL5, IFNG, TGFB1
44	allergic contact dermatitis of eyelid	12.4	TGFB1, IFNG, IL5
45	pemphigus vulgaris	12.4	TGFB1, IL5, IFNG
46	idiopathic pulmonary fibrosis	12.4	IFNG, TGFB1
47	hairy cell leukemia	12.4	IL5, IFNG, TGFB1
48	keratoconjunctivitis	12.3	IL5, IFNG, TGFB1
49	aspergillosis	12.3	TGFB1, IFNG, IL5
50	neuritis	12.3	TGFB1, IL5, IFNG

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to eosinophilia-myalgia syndrome:

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MGI Mouse Phenotypes related to eosinophilia-myalgia syndrome:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	6.9	TGFB1, TYRP1, CRH, IDO1, IFNG, IL5
2	behavior/neurological phenotype	MP:0005386	6.8	SCXB, TDO2, TGFB1, TYRP1, CRH, IFNG

Articles related to eosinophilia-myalgia syndrome:

id	Title	Authors	Year	Affiliating Genes
1	A heretofore undisclosed crux of eosinophilia-myalgia syndrome: compromised histamine degradation. (16307217)	Smith M.J.... Garrett R.H.	2005	HNMT
2	A contaminant of L-tryptophan enhances expression of dermal collagen in a murine model of eosinophilia myalgia syndrome. (8863345)	Suzuki S.... Silver R.	1996	TGFB1
3	1,1'-Ethylidenebis[L-tryptophan], a contaminant implicated in L-tryptophan eosinophilia myalgia syndrome, suppresses mRNA expression of hypothalamic corticotropin-releasing hormone in Lewis (LEW/N) rat brain. (8528886)	Brady L.S.... Smith C.	1994	CRH
4	1,1'-Ethylidenebis(tryptophan) (Peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: association of eosinophilia-myalgia syndrome with a L-tryptophan contaminant. (8132737)	Yamaoka K.A.... Kashiwazaki S.	1994	IL5
5	Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome. (1532618)	Silver R.M.... Heyes M.P.	1992	IFNG, IDO1
6	Hypodense eosinophils and interleukin 5 activity in the blood of patients with the eosinophilia-myalgia syndrome. (2236076)	Owen W.F.... Austen K.F.	1990	IL5

Genes related to eosinophilia-myalgia syndrome according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
2	SCXB	scleraxis homolog B (mouse)	11.0	Disorders
3	SCXA	scleraxis homolog A (mouse)	11.0
4	TDO2	tryptophan 2,3-dioxygenase	11.0
5	HNMT	histamine N-methyltransferase	11.0	Publications
6	TYRP1	tyrosinase-related protein 1	11.0
7	IDO1	indoleamine 2,3-dioxygenase 1	11.0	Publications
8	CRH	corticotropin releasing hormone	11.0	Publications
9	IFNG	interferon, gamma	11.0	Publications
10	TGFB1	transforming growth factor, beta 1	11.0	Publications

Pathways related to eosinophilia-myalgia syndrome according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	OX40 Pathway36	9.4	IL5, IFNG
2	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.4	IL5, TGFB1

Compounds related to eosinophilia-myalgia syndrome according to GeneDecks:

(show all 35)

id	Compound	Score	Top Affiliating Genes
1	toluene diisocyanate32	10.0	HNMT, IL5
2	n-formylkynurenine32	10.0	IDO1, TDO2
3	glatiramer acetate32 9 9	11.6	IFNG, IL5
4	indole32	9.6	IDO1, TDO2
5	amphotericin b32	9.5	IL5, IFNG
6	1-methyltryptophan32	9.5	IDO1, IFNG
7	pirfenidone32	9.5	IFNG, TGFB1
8	tranilast32	9.4	IFNG, TGFB1
9	3-hydroxyanthranilic acid32 18	10.4	IFNG, IDO1
10	imiquimod32 42 9 9	12.4	IL5, IFNG
11	hmba32	9.4	TGFB1, TYRP1
12	sb 20358032 42	10.4	IFNG, CRH
13	il-1232	9.4	IL5, IFNG
14	sodium nitroprusside32	9.3	IL5, CRH, TGFB1
15	quinolinic acid32 18	10.3	TDO2, IDO1
16	gm-csf32	9.2	IL5, IFNG, TGFB1
17	poly(i-c)32	9.2	IL5, IFNG, IDO1
18	thyroxine32 18	10.2	IL5, CRH, TGFB1
19	methylcellulose32	9.2	TGFB1, IFNG, IL5
20	il 1032	9.2	IL5, IFNG, TGFB1
21	5-hydroxytryptamine32	9.2	IDO1, CRH, TDO2
22	kynurenine32	9.2	TDO2, IDO1, IFNG
23	indoleamine32	9.2	TDO2, IDO1, IFNG
24	hydrocortisone32 9 9	11.0	IL5, IFNG, CRH
25	tacrolimus32 34 9 9	11.9	TGFB1, IFNG, IL5
26	l-tryptophan32 9 18 9	11.9	IL5, IFNG, IDO1, TDO2
27	l-nmma32	8.9	IFNG, IDO1, CRH
28	rantes32	8.7	TGFB1, IDO1, IFNG, IL5
29	indomethacin32 9 9	10.5	TGFB1, CRH, IFNG, IL5
30	thymidine32 18	9.5	TGFB1, IDO1, IFNG, IL5
31	histamine32 18	9.2	IL5, IFNG, HNMT, CRH, TGFB1
32	arginine32	8.1	TDO2, CRH, IDO1, IFNG, IL5
33	pge232	8.1	TGFB1, CRH, IDO1, IFNG, IL5
34	cycloheximide32	8.1	TGFB1, CRH, IDO1, IFNG, IL5
35	dexamethasone32 42 34 9 9	12.0	TGFB1, CRH, IDO1, IFNG, IL5

Biological processes related to eosinophilia-myalgia syndrome according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of cartilage development	GO:061035	9.8	SCXA, TGFB1
2	tryptophan catabolic process to kynurenine	GO:019441	9.7	IDO1, TDO2
3	tryptophan catabolic process	GO:006569	9.6	TDO2, IDO1
4	positive regulation of collagen biosynthetic process	GO:032967	9.6	SCXA, TGFB1
5	chondrocyte differentiation	GO:002062	9.6	SCXA, TGFB1
6	positive regulation of interleukin-12 production	GO:032735	9.0	IFNG, IDO1
7	female pregnancy	GO:007565	9.0	IDO1, CRH, TGFB1
8	protein import into nucleus, translocation	GO:000060	8.8	IFNG, TGFB1

Molecular functions related to eosinophilia-myalgia syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	oxygen binding	GO:019825	9.6	IDO1, TDO2
2	amino acid binding	GO:016597	9.3	IDO1, TDO2