MCID: ESN002
MIFTS: 48

Eosinophilia-Myalgia Syndrome malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

About this section

Aliases & Descriptions for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 10 45 47 12 36 65
Ems 45 2
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 45
 
Severe Muscle Pain and Abnormally High Eosinophils 45
Eosinophilia Myalgia Syndrome 10
L-Tryptophan Induced Ems 45

Classifications:



External Ids:

Disease Ontology10 DOID:998
ICD9CM29 710.5
SNOMED-CT59 95416007
MeSH36 D016603
UMLS65 C0085179

Summaries for Eosinophilia-Myalgia Syndrome

About this section
CDC:2 Emergency medical services (EMS) workers provide pre-hospital emergency medical care. Their duties create an inherent risk for on-the-job injuries and illnesses. Research shows that EMS workers have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary: Eosinophilia-Myalgia Syndrome, also known as ems, is related to eosinophilia and toxic oil syndrome, and has symptoms including myalgia, muscle weakness and pain. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways are IgA-Producing B Cells in the Intestine and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include heart, lung and skin, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Wikipedia:68 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

About this section

Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia11.2
2toxic oil syndrome10.6
3fasciitis10.6
4eosinophilic fasciitis10.4
5limbic encephalitis with ncmags antibodies10.4IFNG, IL5
6gonococcal bursitis10.3IFNG, IL5
7kohler's disease10.3IL5, TGFB1
8hepatitis e10.3IFNG, IL5
9postmenopausal atrophic vaginitis10.3IL5, TGFB1
10neonatal infective mastitis10.3IFNG, IL5
11hepatoid adenocarcinoma10.3IFNG, IL5
12opisthorchiasis10.3IFNG, TGFB1
13acute gonococcal epididymo-orchitis10.3IFNG, IL5
14orbital plasma cell granuloma10.3IFNG, IL5
15tuberculoid leprosy10.3IFNG, TGFB1
16polyneuropathy10.3
17leech infestation10.3IFNG, TGFB1
18food allergy10.3IFNG, IL5
19reflex sympathetic dystrophy10.3IFNG, TGFB1
20hodgkin's lymphoma, lymphocytic-histiocytic predominance10.3IFNG, IL5
21bronchopulmonary dysplasia10.2IFNG, TGFB1
22myopathy10.2
23neuropathy10.2
24hard palate cancer10.2IFNG, TGFB1
25deafness, autosomal recessive 6210.2IFNG, IL5
26malignant hyperthermia10.1CRH, TGFB1
27long bone adamantinoma10.1IFNG, IL5
28glycoproteinosis10.1IFNG, TGFB1
29pseudoxanthoma elasticum10.1
30pulmonary hypertension10.1
31peripheral neuropathy10.1
32demyelinating polyneuropathy10.1
33perimyositis10.1
34argentine hemorrhagic fever10.1HNMT, IFNG
35severe acute respiratory syndrome10.1IFNG, IL5
36non specific chronic endometritis10.0IDO1, IL5
37temporal lobe epilepsy10.0IFNG, TGFB1
38cholesteatoma of attic10.0IFNG, IL5, TGFB1
39wissler's syndrome10.0IFNG, IL5, TGFB1
40diffuse scleroderma10.0IFNG, IL5, TGFB1
41pneumocystosis10.0IFNG, IL5
42uterine corpus epithelioid leiomyoma10.0IFNG, IL5, TGFB1
43phenylketonuria10.0
44hepatitis10.0
45leukemia10.0
46skin disease10.0
47mononeuropathy10.0
48hepatitis a10.0
49angioedema10.0
50neuritis10.0

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Symptoms for Eosinophilia-Myalgia Syndrome

About this section

UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


myalgia, muscle weakness, pain, muscle spasticity, muscle rigidity, muscle cramp

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

About this section

Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
15-hydroxytryptophan11
2TryptophanNutraceutical54

Interventional clinical trials:

idNameStatusNCT IDPhase
1L-5-HTP-Related EMSCompletedNCT00001918
2Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical TrialsCompletedNCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome


Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

About this section

Anatomical Context for Eosinophilia-Myalgia Syndrome

About this section

MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

33
Heart, Lung, Skin, Bone, Pituitary, Prostate, Endothelial

Animal Models for Eosinophilia-Myalgia Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Eosinophilia-Myalgia Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0AHR, IFNG, IL5, TGFB1
2MP:00053678.7AHR, CRH, IFNG, TGFB1
3MP:00053708.5AHR, CRH, IFNG, IL5, TGFB1
4MP:00053888.4AHR, CRH, IFNG, IL5, TGFB1
5MP:00053898.0AHR, IDO1, IFNG, IL5, TGFB1
6MP:00053767.4AHR, CRH, IDO1, IFNG, IL5, TGFB1
7MP:00053977.4AHR, CRH, IDO1, IFNG, IL5, TGFB1
8MP:00053877.1AHR, CRH, IDO1, IFNG, IL5, TGFB1

Publications for Eosinophilia-Myalgia Syndrome

About this section

Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 338)
idTitleAuthorsYear
1
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? (19941898)
2010
2
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. (17806156)
2007
3
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. (17892268)
2007
4
Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. (10606395)
1999
5
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome. (9817085)
1998
6
Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. (9076948)
1997
7
The eosinophilia-myalgia syndrome and the toxic oil syndrome. Pursuing parallels. (8906286)
1996
8
1995 Bailey K. Ashford lecture. Public health lessons from two catastrophic epidemics: the toxic oil syndrome and the eosinophilia-myalgia syndrome. (8744866)
1996
9
1,1'-Ethylidenebis[L-tryptophan], an impurity in L-tryptophan associated with eosinophilia-myalgia syndrome, stimulates type I collagen gene expression in human fibroblasts in vitro. (8624499)
1995
10
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
11
Eosinophilia-myalgia syndrome: a long-term follow-up study. (7660215)
1995
12
P-31 magnetic resonance spectroscopy of skeletal muscle in the eosinophilia-myalgia syndrome: a preliminary study. (8035389)
1994
13
Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome. (7955801)
1994
14
The eosinophilia-myalgia syndrome: lessons from Germany. (8015338)
1994
15
Studies with 1,1'-ethylidenebis(tryptophan), a contaminant associated with L-tryptophan implicated in the eosinophilia-myalgia syndrome. (8184420)
1994
16
Eosinophilia myalgia syndrome: absence of immunoglobulin reactivity suggests a cellular rather than humoral mechanism. (7976226)
1994
17
Eosinophilia-myalgia syndrome in Germany: an epidemiologic review. (8015323)
1994
18
Production of polyclonal antibodies against 1,1'-ethyliden bis[L-tryptophan] (EBT), a potential contaminant causing eosinophilia-myalgia syndrome (EMS). (8475503)
1993
19
Eosinophilia-myalgia syndrome and fasciitis with an active alveolitis. (8355447)
1993
20
Toxic oil syndrome and eosinophilia-myalgia syndrome: May 8-10, 1991, World Health Organization meeting report. (8266108)
1993
21
The eosinophilia-myalgia syndrome: current concepts and future directions. (1551286)
1992
22
Eosinophilia-myalgia syndrome. Natural history in a population-based cohort. (1520057)
1992
23
Eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1386918)
1992
24
Central nervous system involvement in the eosinophilia-myalgia syndrome. (1417516)
1992
25
A histopathologic comparison of Shulman's syndrome (diffuse fasciitis with eosinophilia) and the fasciitis associated with the eosinophilia-myalgia syndrome. (1732344)
1992
26
Identification of decomposition products of 1,1'-ethylidenebis [L-tryptophan], a compound associated with eosinophilia-myalgia syndrome. (1504513)
1992
27
Episodic angioedema with eosinophilia versus eosinophilia-myalgia syndrome. (1583248)
1992
28
Chronic demyelinating polyneuropathy associated with eosinophilia-myalgia syndrome. (1534836)
1992
29
Eosinophilia-myalgia syndrome: the aftermath. (1523446)
1992
30
Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1929872)
1991
31
Environmental pathology. Mast cell and eosinophil infiltration in intestinal mucosa of Lewis rats treated with L-tryptophan implicated in human eosinophilia myalgia syndrome. (2068062)
1991
32
Eosinophilia-myalgia syndrome: the Cleveland Clinic experience. (1934454)
1991
33
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (1984598)
1991
34
L-tryptophan-induced eosinophilia-myalgia syndrome. (1829754)
1991
35
Postmortem studies of the heart in three fatal cases of the eosinophilia-myalgia syndrome. (2058857)
1991
36
Unraveling the eosinophilia-myalgia syndrome. (1863082)
1991
37
Eosinophilia-myalgia syndrome. A clinical case series of 21 patients. New Mexico Eosinophilia-Myalgia Syndrome Study Group. (2001136)
1991
38
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
39
Dermal mucinosis in the eosinophilia-myalgia syndrome. (2241211)
1990
40
The eosinophilia-myalgia syndrome. (2339858)
1990
41
Clinical spectrum of the systemic manifestations of the eosinophilia-myalgia syndrome. (2164712)
1990
42
Eosinophilia-myalgia syndrome: unresolved questions. (2372919)
1990
43
Peripheral neuropathy in the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. (2162498)
1990
44
L-tryptophan induced eosinophilia-myalgia syndrome. (2273498)
1990
45
Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome. (2166897)
1990
46
Eosinophilia-myalgia syndrome. Results of national surveillance. (2398610)
1990
47
The eosinophilia-myalgia syndrome with neuritis associated with L-tryptophan use. (2339856)
1990
48
Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States, as of January 9, 1990. (2104651)
1990
49
Eosinophilia-myalgia syndrome with myoclonic jerks. (2292676)
1990
50
Eosinophilia-myalgia syndrome--New Mexico. (2509886)
1989

Variations for Eosinophilia-Myalgia Syndrome

About this section

Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

About this section
Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

About this section

GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

About this section

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-17 productionGO:003270010.2IFNG, TGFB1
2positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.1IL5, TGFB1
3cell cycle arrestGO:000705010.1IFNG, TGFB1
4protein import into nucleus, translocationGO:000006010.0IFNG, TGFB1
5positive regulation of protein phosphorylationGO:00019349.9CRH, TGFB1
6extrinsic apoptotic signaling pathwayGO:00971919.9IFNG, TGFB1
7cellular response to dexamethasone stimulusGO:00715499.7CRH, TGFB1
8response to cocaineGO:00422209.4CRH, HNMT
9negative regulation of gene expressionGO:00106299.3CRH, IFNG, TGFB1
10response to drugGO:00424939.2CRH, IFNG, TGFB1
11inflammatory responseGO:00069549.0IDO1, IL5, TGFB1
12female pregnancyGO:00075659.0CRH, IDO1, TGFB1
13positive regulation of transcription, DNA-templatedGO:00458939.0AHR, IFNG, IL5, TGFB1
14positive regulation of gene expressionGO:00106288.8CRH, IFNG, TGFB1
15positive regulation of cell proliferationGO:00082848.6CRH, IFNG, IL5, TGFB1

Sources for Eosinophilia-Myalgia Syndrome

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet