MCID: ESN002
MIFTS: 46

Eosinophilia-Myalgia Syndrome

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

MalaCards integrated aliases for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 12 49 51 41 14 69
Ems 49 3
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 49
Severe Muscle Pain and Abnormally High Eosinophils 49
Eosinophilia Myalgia Syndrome 12
L-Tryptophan Induced Ems 49

Classifications:



External Ids:

Disease Ontology 12 DOID:998
ICD9CM 34 710.5
MeSH 41 D016603
SNOMED-CT 64 95416007
UMLS 69 C0085179

Summaries for Eosinophilia-Myalgia Syndrome

CDC : 3 Emergency medical services (EMS) workers provide pre-hospital emergency medical care. Their duties create an inherent risk for on-the-job injuries and illnesses. Research shows that EMS workers have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary : Eosinophilia-Myalgia Syndrome, also known as ems, is related to toxic oil syndrome and eosinophilic fasciitis, and has symptoms including myalgia, muscle weakness and muscle spasticity. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs 5-hydroxytryptophan and Tryptophan have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung.

Wikipedia : 72 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological condition... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 toxic oil syndrome 31.2 IFNG IL5
2 eosinophilic fasciitis 31.0 IFNG IL5
3 fasciitis 10.5
4 pustulosis palmaris et plantaris 10.3 IL5 TGFB1
5 norwegian scabies 10.3 IL5 TGFB1
6 atopic keratoconjunctivitis 10.3 IFNG IL5
7 ascaris lumbricoides infection 10.3 IFNG IL5
8 urinary schistosomiasis 10.2 IFNG IL5
9 folliculitis 10.2 IFNG IL5
10 multicentric castleman disease 10.2 IFNG IL5
11 allergic conjunctivitis 10.2 IFNG IL5
12 polyneuropathy 10.2
13 paracoccidioidomycosis 10.2 IFNG IL5
14 esophagitis 10.2 IL5 TGFB1
15 pemphigoid gestationis 10.2 HLA-DRB1 IL5
16 clonorchiasis 10.2 IFNG TGFB1
17 tuberculoid leprosy 10.2 IFNG TGFB1
18 autoimmune disease of gastrointestinal tract 10.2 HLA-DQA1 IFNG
19 conjunctivitis 10.2 IFNG IL5
20 chronic active epstein-barr virus infection 10.2 IFNG TGFB1
21 filariasis 10.2 IFNG IL5
22 keratoconjunctivitis 10.2 IFNG IL5
23 focal epithelial hyperplasia 10.2 HLA-DQA1 HLA-DRB1
24 food allergy 10.2 IFNG IL5
25 recurrent respiratory papillomatosis 10.2 HLA-DQA1 HLA-DRB1
26 allergic contact dermatitis 10.2 IFNG IL5
27 acute disseminated encephalomyelitis 10.2 HLA-DQA1 HLA-DRB1
28 sympathetic ophthalmia 10.1 HLA-DQA1 HLA-DRB1
29 episodic pain syndrome, familial, 1 10.1
30 myopathy 10.1
31 neuropathy 10.1
32 chronic mucocutaneous candidiasis 10.1 IFNG IL5
33 juvenile myasthenia gravis 10.1 HLA-DRB1 TGFB1
34 gastroenteritis 10.1 IFNG IL5
35 cutaneous leishmaniasis 10.1 IFNG IL5
36 aspergillosis 10.1 IFNG IL5
37 autoinflammation, lipodystrophy, and dermatosis syndrome 10.1 IFNG IL5
38 contact dermatitis 10.1 IFNG IL5
39 berylliosis 10.1 HLA-DRB1 IFNG
40 chronic beryllium disease 10.1 HLA-DRB1 IFNG
41 ocular cicatricial pemphigoid 10.1 HLA-DRB1 TGFB1
42 idiopathic neutropenia 10.1 HLA-DRB1 TGFB1
43 microscopic colitis 10.1 HLA-DRB1 IFNG
44 central nervous system vasculitis 10.1 HLA-DRB1 IFNG
45 pseudoxanthoma elasticum 10.1
46 pulmonary hypertension 10.1
47 demyelinating polyneuropathy 10.1
48 perimyositis 10.1
49 histoplasmosis 10.1 HLA-DRB1 IFNG
50 sezary's disease 10.1 IFNG IL5

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to Eosinophilia-Myalgia Syndrome

Symptoms & Phenotypes for Eosinophilia-Myalgia Syndrome

UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


myalgia, muscle weakness, muscle spasticity, muscle rigidity, muscle cramp

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 5-hydroxytryptophan
2 Tryptophan Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 L-5-HTP-Related EMS Completed NCT00001918
2 Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical Trials Completed NCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

Anatomical Context for Eosinophilia-Myalgia Syndrome

MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

38
Skin, Heart, Lung, Brain, T Cells, Neutrophil, Liver

Publications for Eosinophilia-Myalgia Syndrome

Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50) (show all 339)
# Title Authors Year
1
Structure determination of disease associated peak AAA from l-Tryptophan implicated in the eosinophilia-myalgia syndrome. ( 29037509 )
2018
2
Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan. ( 21702023 )
2011
3
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? ( 19941898 )
2010
4
Immunogenetic risk and protective factors for the development of L-tryptophan-associated eosinophilia-myalgia syndrome and associated symptoms. ( 19790128 )
2009
5
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. ( 17892268 )
2007
6
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. ( 17806156 )
2007
7
Calcinosis cutis in a patient with eosinophilia-myalgia syndrome: case report. ( 16838769 )
2006
8
A heretofore undisclosed crux of eosinophilia-myalgia syndrome: compromised histamine degradation. ( 16307217 )
2005
9
Non-L-tryptophan related eosinophilia-myalgia syndrome with hypoproteinemia and hypoalbuminemia. ( 12610828 )
2003
10
Rigorous new approach to constructing a gold standard for validating new diagnostic criteria, as exemplified by the eosinophilia-myalgia syndrome. ( 11606145 )
2001
11
Eosinophilic cholecystitis as a possible late manifestation of the eosinophilia-myalgia syndrome. ( 11147758 )
2000
12
Structural characterization of case-associated contaminants peak C and FF in L-tryptophan implicated in eosinophilia-myalgia syndrome. ( 10721088 )
1999
13
Is there any relationship between eosinophilia myalgia syndrome (EMS) and fibromyalgia syndrome (FMS)? An analysis of clinical and immunological data. ( 10721092 )
1999
14
Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. ( 10606395 )
1999
15
Eosinophilia-myalgia syndrome and giant cell myocarditis: a case report and therapeutic approach. ( 11720607 )
1999
16
Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan. ( 10721089 )
1999
17
Pain, fatigue, and sleep in eosinophilia-myalgia syndrome: relationship to neuropsychological performance. ( 9706542 )
1998
18
Neurologic, MR imaging, and MR spectroscopic findings in eosinophilia myalgia syndrome. ( 9802492 )
1998
19
Structural characterization of contaminants found in commercial preparations of melatonin: similarities to case-related compounds from L-tryptophan associated with eosinophilia-myalgia syndrome. ( 9544622 )
1998
20
L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia. ( 9858150 )
1998
21
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome. ( 9817085 )
1998
22
Rapid HPLC screening method for contaminants found in implicated L-tryptophan associated with eosinophilia myalgia syndrome and adulterated rapeseed oil associated with toxic oil syndrome. ( 9787895 )
1998
23
Elevated L-kynurenine level and its normalization by prednisolone in a patient with eosinophilia-myalgia syndrome. ( 9037890 )
1997
24
On-line HPLC-tandem mass spectrometry analysis of contaminants of L-tryptophan associated with the onset of the eosinophilia-myalgia syndrome. ( 9295237 )
1997
25
Eosinophilia-myalgia syndrome: selective cognitive impairment, longitudinal effects, and neuroimaging findings. ( 9408106 )
1997
26
Eosinophilia-myalgia syndrome, eosinophilic fasciitis, and related fibrosing disorders. ( 9375286 )
1997
27
Eosinophilia-myalgia syndrome: opportunities realized and missed. ( 9195545 )
1997
28
The eosinophilia myalgia syndrome: to be or not to be. ( 9213375 )
1997
29
Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. ( 9076948 )
1997
30
Eosinophilia-myalgia syndrome: description of an unusual case. ( 9196880 )
1997
31
Eosinophilia myalgia syndrome. ( 9213377 )
1997
32
Fibromyalgia, psychiatric disorders, and assessment of the longterm outcome of eosinophilia-myalgia syndrome. ( 8895180 )
1996
33
The eosinophilia-myalgia syndrome and the toxic oil syndrome. Pursuing parallels. ( 8906286 )
1996
34
A diagnostic algorithm for distinguishing the eosinophilia-myalgia syndrome from fibromyalgia and chronic myofascial pain. ( 8895177 )
1996
35
Eosinophilia-myalgia syndrome. Status of patients at onset and after four years of disease. ( 8906291 )
1996
36
Pathophysiology of the eosinophilia-myalgia syndrome. ( 8895179 )
1996
37
Eosinophilia myalgia syndrome. The role of contaminants, the role of serotonergic metabolism set up. ( 8906288 )
1996
38
Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. ( 8895184 )
1996
39
Cognitive deficits in a murine model of the eosinophilia-myalgia syndrome: a preliminary report. ( 8888024 )
1996
40
Eosinophilia-Myalgia Syndrome: Review and Reappraisal of Clinical, Epidemiologic and Animal Studies Symposium. Washington, D.C., USA, December 7-8, 1994. Proceedings. ( 9053528 )
1996
41
Epidemiologic studies of the association of L-tryptophan with the eosinophilia-myalgia syndrome: a critique. ( 8895181 )
1996
42
A contaminant of L-tryptophan enhances expression of dermal collagen in a murine model of eosinophilia myalgia syndrome. ( 8863345 )
1996
43
Eosinophilia-myalgia syndrome: patient status 2-4 years after onset. ( 8895178 )
1996
44
Criteria for the definition of the eosinophilia-myalgia syndrome. ( 8895176 )
1996
45
The eosinophilia-myalgia syndrome revisited. ( 8895139 )
1996
46
Effect of L-tryptophan products on function of human eosinophils: investigation of the causal mechanisms of eosinophilia myalgia syndrome associated with L-tryptophan products. ( 8906111 )
1996
47
EBT, a tryptophan contaminant associated with eosinophilia myalgia syndrome, is incorporated into proteins during translation as an amino acid analog. ( 9161698 )
1996
48
Pathogenesis of L-tryptophan eosinophilia myalgia syndrome. ( 8906284 )
1996
49
A comparative study of tissue distribution and excretion among three substances implicated in eosinophilia-myalgia syndrome. ( 8906290 )
1996
50
Animal models of the eosinophilia-myalgia syndrome. ( 8895185 )
1996

Variations for Eosinophilia-Myalgia Syndrome

Expression for Eosinophilia-Myalgia Syndrome

Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for Eosinophilia-Myalgia Syndrome

Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
2
Show member pathways
12.46 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
3
Show member pathways
12.36 HLA-DQA1 HLA-DRB1 IFNG
4
Show member pathways
12.25 HLA-DQA1 HLA-DRB1 IFNG
5
Show member pathways
12.15 IFNG IL5 TGFB1
6 12.13 HLA-DQA1 HLA-DRB1 TGFB1
7
Show member pathways
12.09 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
8 11.98 HLA-DQA1 HLA-DRB1 IFNG
9
Show member pathways
11.98 HLA-DQA1 HLA-DRB1 IFNG TGFB1
10 11.92 HLA-DQA1 HLA-DRB1 IFNG TGFB1
11 11.6 HLA-DQA1 HLA-DRB1 IL5
12
Show member pathways
11.53 HLA-DQA1 HLA-DRB1
13 11.46 IL5 TGFB1
14 11.45 IFNG TGFB1
15 11.42 IL5 TGFB1
16 11.38 IFNG TGFB1
17 11.36 HLA-DQA1 HLA-DRB1
18 11.3 IFNG TGFB1
19 11.28 IFNG TGFB1
20 11.25 IFNG IL5
21 11.21 HLA-DQA1 HLA-DRB1 IFNG TGFB1
22
Show member pathways
11.12 IFNG TGFB1
23 11.05 IFNG IL5
24 11.03 IFNG IL5
25 10.93 IFNG IL5
26 10.88 HLA-DRB1 IFNG TGFB1
27 10.54 IL5 TGFB1
28 10.4 HLA-DRB1 IFNG IL5 TGFB1

GO Terms for Eosinophilia-Myalgia Syndrome

Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle membrane GO:0030666 9.37 HLA-DQA1 HLA-DRB1
2 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQA1 HLA-DRB1
3 transport vesicle membrane GO:0030658 9.26 HLA-DQA1 HLA-DRB1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQA1 HLA-DRB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQA1 HLA-DRB1
6 MHC class II protein complex GO:0042613 8.62 HLA-DQA1 HLA-DRB1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.75 CRH IL5 TGFB1
2 positive regulation of gene expression GO:0010628 9.74 CRH IFNG TGFB1
3 negative regulation of gene expression GO:0010629 9.65 CRH IFNG TGFB1
4 positive regulation of cell proliferation GO:0008284 9.62 CRH IFNG IL5 TGFB1
5 positive regulation of protein phosphorylation GO:0001934 9.58 CRH IFNG TGFB1
6 antigen processing and presentation GO:0019882 9.56 HLA-DQA1 HLA-DRB1
7 extrinsic apoptotic signaling pathway GO:0097191 9.55 IFNG TGFB1
8 negative regulation of T cell proliferation GO:0042130 9.54 HLA-DRB1 TGFB1
9 cellular response to dexamethasone stimulus GO:0071549 9.52 CRH TGFB1
10 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.51 CRH HLA-DRB1
11 protein import into nucleus, translocation GO:0000060 9.49 IFNG TGFB1
12 response to immobilization stress GO:0035902 9.46 CRH TGFB1
13 immune response GO:0006955 9.46 HLA-DQA1 HLA-DRB1 IFNG IL5
14 positive regulation of protein complex assembly GO:0031334 9.43 IFNG TGFB1
15 regulation of regulatory T cell differentiation GO:0045589 9.37 IFNG TGFB1
16 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQA1 HLA-DRB1
17 negative regulation of interleukin-17 production GO:0032700 8.96 IFNG TGFB1
18 interferon-gamma-mediated signaling pathway GO:0060333 8.8 HLA-DQA1 HLA-DRB1 IFNG

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-DQA1 HLA-DRB1
2 cytokine activity GO:0005125 9.13 IFNG IL5 TGFB1
3 MHC class II receptor activity GO:0032395 8.62 HLA-DQA1 HLA-DRB1

Sources for Eosinophilia-Myalgia Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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