EMS
MCID: ESN002
MIFTS: 50

Eosinophilia-Myalgia Syndrome (EMS) malady

Summaries for Eosinophilia-Myalgia Syndrome

Sources:
3CDC, 64Wikipedia, 33MalaCards
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CDC:3 Emergency medical services (EMS) workers are primary providers of pre-hospital emergency medical care and integral components of disaster response. The potentially hazardous job duties of EMS workers include lifting patients and equipment, treating patients with infectious illnesses, handling hazardous chemical and body substances, and participating in the emergency transport of patients in ground and air vehicles. These duties create an inherent risk for EMS worker occupational injuries and illnesses; and research has shown that they have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards: Eosinophilia-Myalgia Syndrome, also known as syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart, is related to eosinophilic fasciitis and bipolar disorder. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde and Cytokines and Inflammatory Response. The compounds indoleamine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are reproductive system and tumorigenesis.

Wikipedia:64 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological... more...

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

eosinophilia-myalgia syndrome 8 43 10 45 61
syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart 43
severe muscle pain and abnormally high eosinophils 43
eosinophilia myalgia syndrome 8
l-tryptophan induced ems 43
ems 43


External Ids:

Disease Ontology8 DOID:998
ICD9CM27 710.5
SNOMED-CT57 95416007
MeSH35 D016603

Related Diseases for Eosinophilia-Myalgia Syndrome

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Clinical Features for Eosinophilia-Myalgia Syndrome

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Eosinophilia-Myalgia Syndrome

Drug clinical trials:

Search ClinicalTrials for Eosinophilia-Myalgia Syndrome

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Search CenterWatch for Eosinophilia-Myalgia Syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

Anatomical Context for Eosinophilia-Myalgia Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

33
Brain, Spinal cord, Heart, Skeletal muscle, Liver, Lung, Skin, T cells, B cells

Animal Models for Eosinophilia-Myalgia Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Eosinophilia-Myalgia Syndrome

Sources:
51PubMed
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Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 339)
idTitleAuthorsYear
1
Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. (10606395)
1999
2
Is there any relationship between eosinophilia myalgia syndrome (EMS) and fibromyalgia syndrome (FMS)? An analysis of clinical and immunological data. (10721092)
1999
3
L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia. (9858150)
1998
4
Eosinophilia myalgia syndrome. (9213377)
1997
5
Antiphospholipid antibodies in patients with eosinophilia myalgia and toxic oil syndrome. (9002013)
1997
6
Eosinophilia-myalgia syndrome: description of an unusual case. (9196880)
1997
7
Persistent microvasculopathy in chronic eosinophilia-myalgia syndrome. (8906289)
1996
8
Analysis of Centers for Disease Control and Prevention criteria for the eosinophilia-myalgia syndrome in a geographically defined population. (8895183)
1996
9
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
10
L-tryptophan: eosinophilia-myalgia syndrome. (7612781)
1995
11
Antineutrophil cytoplasmic antibodies and the eosinophilia myalgia syndrome. (7748023)
1995
12
Head and neck manifestations of eosinophilia-myalgia syndrome. (7857025)
1995
13
P-31 magnetic resonance spectroscopy of skeletal muscle in the eosinophilia-myalgia syndrome: a preliminary study. (8035389)
1994
14
The eosinophilia-myalgia syndrome: lessons from Germany. (8015338)
1994
15
A murine model of the eosinophilia-myalgia syndrome induced by 1,1'-ethylidenebis (L-tryptophan). (8163652)
1994
16
Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents. (8033924)
1994
17
1,1'-Ethylidenebis[tryptophan] induces pathologic alterations in muscle similar to those observed in the eosinophilia-myalgia syndrome. (7991132)
1994
18
Chronicity of the eosinophilia-myalgia syndrome. A reassessment after three years. (8129767)
1994
19
The toxic oil syndrome and the eosinophilia-myalgia syndrome: pursuing clinical parallels. (8295182)
1993
20
Increased type I collagen gene expression in L-tryptophan associated eosinophilia-myalgia syndrome skin fibroblasts. (8230009)
1993
21
Chronic demyelinating polyneuropathy associated with eosinophilia-myalgia syndrome. (1534836)
1992
22
3-(Phenylamino)alanine, a novel aniline-derived amino acid associated with the eosinophilia-myalgia syndrome: a link to the toxic oil syndrome? (1469924)
1992
23
Autoantibodies to nuclear lamin C in the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. (1290474)
1992
24
Pulmonary manifestations of the eosinophilia-myalgia syndrome associated with tryptophan ingestion. (1582284)
1992
25
Repeated coronary artery spasm in a young woman with the eosinophilia-myalgia syndrome. (1583764)
1992
26
Eosinophilia-myalgia syndrome: the Cleveland Clinic experience. (1934454)
1991
27
Eosinophilia-myalgia syndrome. (2027503)
1991
28
L-tryptophan-induced eosinophilia-myalgia syndrome. II. Partial correction of abnormal tryptophan metabolism by pyridoxine. (1722762)
1991
29
Cardiac abnormalities in the toxic oil syndrome, with comparative observations on the eosinophilia-myalgia syndrome. (1918715)
1991
30
Eosinophilia-myalgia syndrome. (1877190)
1991
31
L-tryptophan and the eosinophilia-myalgia syndrome: pathologic findings in eight patients. (1985073)
1991
32
Clinical follow-up and immunogenetic studies of 32 patients with eosinophilia-myalgia syndrome. (1673503)
1991
33
Eosinophilia-myalgia syndrome. (1893558)
1991
34
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
35
Clinical spectrum of the systemic manifestations of the eosinophilia-myalgia syndrome. (2164712)
1990
36
Eosinophilia-myalgia syndrome. Results of national surveillance. (2398610)
1990
37
The eosinophilia-myalgia syndrome. (2139551)
1990
38
Eosinophilia-myalgia syndrome--Canada. (2110292)
1990
39
Tryptophan-induced eosinophilia-myalgia syndrome. (2314425)
1990
40
Characterization of "peak E," a novel amino acid associated with eosinophilia-myalgia syndrome. (2270484)
1990
41
L-tryptophan and the eosinophilia-myalgia syndrome. (2131206)
1990
42
Microangiopathy in the eosinophilia-myalgia syndrome. (2273500)
1990
43
Hypodense eosinophils and interleukin 5 activity in the blood of patients with the eosinophilia-myalgia syndrome. (2236076)
1990
44
Eosinophilia-myalgia syndrome in association with L-tryptophan ingestion. (2273503)
1990
45
L-tryptophan-induced eosinophilia-myalgia syndrome and myopathy. (2215960)
1990
46
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (2273499)
1990
47
Eosinophilic fasciitis associated with the eosinophilia-myalgia syndrome. (2337110)
1990
48
Eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. Analysis of four patients and implications for differential diagnosis and pathogenesis. (2222105)
1990
49
Eosinophilia-myalgia syndrome. (2344580)
1990
50
Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States, through August 24, 1990. (2117243)
1990

Genetic Variations for Eosinophilia-Myalgia Syndrome

Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilia-Myalgia Syndrome

Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

Sources:
38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 52QIAGEN, 30KEGG
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Compounds for genes affiliated with Eosinophilia-Myalgia Syndrome

Sources:
45Novoseek, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB
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Compounds related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1indoleamine4510.6TDO2
2pge24510.5TGFB1
3gm-csf45 2911.5IFNG
4hydrocortisone45 2 60 1113.4CRH
5tranilast4510.4IFNG
6n-formylkynurenine4510.3TDO2, IDO1
7glutamate4510.3AHR
8toluene diisocyanate4510.2IL5, HNMT
91-methyltryptophan4510.2IFNG, IDO1
103-hydroxyanthranilic acid45 2411.1IDO1, IFNG
11kynurenine459.9TDO2, IFNG, IDO1
12poly(i-c)459.9IDO1, IFNG, IL5
135-hydroxytryptamine459.8IDO1, CRH, TDO2
14l-nmma459.8IDO1, IFNG, CRH
15il 10459.8TGFB1, IL5, IFNG
16sodium nitroprusside459.8TGFB1, IL5, CRH
17rantes459.8TGFB1, IFNG, IDO1
18il-12459.7IFNG, IL5
19serine459.7TGFB1, TDO2, TYRP1
20dpa 1459.7HLA-DQA1, HLA-DRB1
21gold sodium thiomalate459.7HLA-DRB1, IFNG
22l-tryptophan45 29 11 2412.7TDO2, IL5, IFNG, IDO1
23glatiramer acetate45 1110.6IFNG, HLA-DRB1, IL5
24herbimycin a45 6010.6IL5, AHR, IFNG
25aspartate459.5CRH, AHR, TDO2
26allergens459.5IL5, HLA-DRB1, IFNG
27carbon459.5TDO2, AHR, CRH
28indomethacin45 60 29 1112.5IFNG, CRH, IL5, TGFB1
29thyroxine45 2410.5CRH, AHR, IL5, TGFB1
30tacrolimus45 50 1111.4TGFB1, IL5, IFNG
31vitamin d459.4CRH, AHR, IL5, TGFB1
32methylcellulose459.4IFNG, AHR, IL5, TGFB1
33lapatinib45 50 1111.3HLA-DQA1, HLA-DRB1
34thymidine45 2410.3IDO1, IFNG, IL5, TGFB1
35histamine45 29 2411.2HNMT, IFNG, CRH, IL5, TGFB1
36sb 20358045 6010.1TGFB1, IL5, AHR, CRH, IFNG
37cysteine458.8IL5, AHR, TYRP1, CRH, IFNG
38adenylate458.8IL5, AHR, TYRP1, CRH
39dexamethasone45 50 29 1111.8IDO1, IFNG, CRH, AHR, IL5, TGFB1
40alanine458.7HLA-DRB1, CRH, AHR, TDO2, TGFB1
41oligonucleotide458.7TGFB1, TYRP1, HLA-DQA1, HLA-DRB1, IDO1
42arginine457.8TDO2, IDO1, IFNG, HLA-DRB1, HLA-DQA1, CRH

GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.3HLA-DQA1, HLA-DRB1
2clathrin-coated endocytic vesicle membraneGO:0306698.7TYRP1, HLA-DQA1, HLA-DRB1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1tryptophan catabolic process to kynurenineGO:01944110.1TDO2, IDO1
2tryptophan catabolic processGO:00656910.1TDO2, IDO1
3cellular response to dexamethasone stimulusGO:07154910.0CRH, TGFB1
4female pregnancyGO:0075659.7TGFB1, CRH, IDO1
5extrinsic apoptotic signaling pathwayGO:0971919.7TGFB1, IFNG
6positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.6CRH, HLA-DRB1
7protein import into nucleus, translocationGO:0000609.6TGFB1, IFNG
8regulation of cartilage developmentGO:0610359.5TGFB1, SCXA
9positive regulation of interleukin-12 productionGO:0327359.5IFNG, IDO1
10positive regulation of collagen biosynthetic processGO:0329679.3SCXA, TGFB1
11interferon-gamma-mediated signaling pathwayGO:0603339.2IFNG, HLA-DRB1, HLA-DQA1
12positive regulation of gene expressionGO:0106289.0TGFB1, CRH, SCXA
13cytokine-mediated signaling pathwayGO:0192218.9IL5, HLA-DQA1, HLA-DRB1, IFNG

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.0HLA-DQA1, HLA-DRB1
2protein heterodimerization activityGO:0469828.5TGFB1, AHR, TYRP1, SCXA

Products for genes affiliated with Eosinophilia-Myalgia Syndrome

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Sources for Eosinophilia-Myalgia Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet