EMS
MCID: ESN002
MIFTS: 42

Eosinophilia-Myalgia Syndrome (EMS) malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

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Aliases & Descriptions for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 11 48 50 39 13 68
Ems 48 2
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 48
 
Severe Muscle Pain and Abnormally High Eosinophils 48
Eosinophilia Myalgia Syndrome 11
L-Tryptophan Induced Ems 48

Classifications:



External Ids:

Disease Ontology11 DOID:998
ICD9CM32 710.5
SNOMED-CT62 95416007
MeSH39 D016603

Summaries for Eosinophilia-Myalgia Syndrome

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CDC:2 Emergency medical services (EMS) workers provide pre-hospital emergency medical care. Their duties create an inherent risk for on-the-job injuries and illnesses. Research shows that EMS workers have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary: Eosinophilia-Myalgia Syndrome, also known as EMS, is related to hepatitis and toxic oil syndrome, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways are Inflammatory Response Pathway and OX40 Pathway. Affiliated tissues include skin, heart and lung.

Wikipedia:71 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

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Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis29.9HLA-DRB1, IFNG
2toxic oil syndrome10.5
3fasciitis10.5
4eosinophilic fasciitis10.3
5cataract, total congenital10.2IFNG, IL5
6spastic diplegia10.2IFNG, IL5
7multiple epiphyseal dysplasia due to collagen 9 anomaly10.2IFNG, IL5
8urethral intrinsic sphincter deficiency10.2IFNG, IL5
9hemangioma of spleen10.2IFNG, IL5
10acute gonococcal prostatitis10.2IFNG, IL5
11cutaneous fibrous histiocytoma10.2IFNG, IL5
12peptidic growth factors deficiency10.2HLA-DRB1, IL5
13multiple mitochondrial dysfunctions syndrome10.2IFNG, IL5
14hemoglobin d disease10.2HLA-DQA1, HLA-DRB1
15bilateral parasagittal parieto-occipital polymicrogyria10.2HLA-DQA1, HLA-DRB1
16abnormal retinal correspondence10.2IFNG, IL5
17kernicterus due to isoimmunization10.2HLA-DQA1, HLA-DRB1
18cervical adenoid basal carcinoma10.2HLA-DQA1, HLA-DRB1
19hydrophthalmos10.2IFNG, IL5
20caplan's syndrome10.1HLA-DRB1, IFNG
21hyperlucent lung10.1HLA-DQA1, IFNG
22loiasis10.1IFNG, IL5
23distal trisomy 14q10.1HLA-DRB1, IFNG
24oromandibular dystonia10.1HLA-DQA1, HLA-DRB1
25autosomal recessive congenital methemoglobinemia10.1IFNG, IL5
26polyneuropathy10.1
27clostridium difficile colitis10.1HLA-DRB1, IFNG
28benign meningioma10.1IDO1, IL5
29acanthoma10.1HLA-DRB1, IFNG
30pancreatic signet ring cell adenocarcinoma10.1HLA-DRB1, IFNG
31autoimmune disease of skin and connective tissue10.1HLA-DQA1, IFNG
32hereditary alpha tryptasemia syndrome10.1HLA-DRB1, IFNG
33ragweed sensitivity10.1HLA-DQA1, HLA-DRB1
34benign deep fibrous histiocytoma10.1HLA-DRB1, IFNG
35plummer's disease10.1HLA-DRB1, IFNG
36variola minor10.1IDO1, IFNG
37peripheral artery disease10.1HLA-DQA1, HLA-DRB1
38mansonelliasis10.1IFNG, IL5
39chronic thromboembolic pulmonary hypertension10.1IDO1, IFNG
40tracheitis10.1IFNG, IL5
41myopathy10.1
42neuropathy10.1
43stiff-person syndrome10.1HLA-DRB1, IFNG
44balkan nephropathy10.1IFNG, IL5
45heart conduction disease10.1HLA-DRB1, IFNG
46depressed scar10.0HLA-DRB1, IFNG
47paratyphoid fever10.0IFNG, IL5
48inflammatory bowel disease 210.0IFNG, IL5
49gastroschisis abdominal wall defects, included10.0AHR, IFNG, IL5
50disease of mental health10.0HLA-DRB1, IFNG, IL5

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Symptoms & Phenotypes for Eosinophilia-Myalgia Syndrome

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UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


muscle cramp, muscle rigidity, muscle spasticity, muscle weakness, myalgia

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

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Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
15-hydroxytryptophan13
2TryptophanNutraceutical64

Interventional clinical trials:

idNameStatusNCT IDPhase
1L-5-HTP-Related EMSCompletedNCT00001918
2Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical TrialsCompletedNCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome


Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

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Anatomical Context for Eosinophilia-Myalgia Syndrome

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MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

36
Skin, Heart, Lung, Brain, T cells, Neutrophil, Liver

Publications for Eosinophilia-Myalgia Syndrome

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Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 338)
idTitleAuthorsYear
1
Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan. (21702023)
2011
2
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? (19941898)
2010
3
Immunogenetic risk and protective factors for the development of L-tryptophan-associated eosinophilia-myalgia syndrome and associated symptoms. (19790128)
2009
4
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. (17806156)
2007
5
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. (17892268)
2007
6
Calcinosis cutis in a patient with eosinophilia-myalgia syndrome: case report. (16838769)
2006
7
A heretofore undisclosed crux of eosinophilia-myalgia syndrome: compromised histamine degradation. (16307217)
2005
8
Non-L-tryptophan related eosinophilia-myalgia syndrome with hypoproteinemia and hypoalbuminemia. (12610828)
2003
9
Rigorous new approach to constructing a gold standard for validating new diagnostic criteria, as exemplified by the eosinophilia-myalgia syndrome. (11606145)
2001
10
Eosinophilic cholecystitis as a possible late manifestation of the eosinophilia-myalgia syndrome. (11147758)
2000
11
Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan. (10721089)
1999
12
Eosinophilia-myalgia syndrome and giant cell myocarditis: a case report and therapeutic approach. (11720607)
1999
13
Is there any relationship between eosinophilia myalgia syndrome (EMS) and fibromyalgia syndrome (FMS)? An analysis of clinical and immunological data. (10721092)
1999
14
Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. (10606395)
1999
15
Structural characterization of case-associated contaminants peak C and FF in L-tryptophan implicated in eosinophilia-myalgia syndrome. (10721088)
1999
16
Rapid HPLC screening method for contaminants found in implicated L-tryptophan associated with eosinophilia myalgia syndrome and adulterated rapeseed oil associated with toxic oil syndrome. (9787895)
1998
17
Pain, fatigue, and sleep in eosinophilia-myalgia syndrome: relationship to neuropsychological performance. (9706542)
1998
18
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome. (9817085)
1998
19
Neurologic, MR imaging, and MR spectroscopic findings in eosinophilia myalgia syndrome. (9802492)
1998
20
L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia. (9858150)
1998
21
Structural characterization of contaminants found in commercial preparations of melatonin: similarities to case-related compounds from L-tryptophan associated with eosinophilia-myalgia syndrome. (9544622)
1998
22
Eosinophilia-myalgia syndrome: selective cognitive impairment, longitudinal effects, and neuroimaging findings. (9408106)
1997
23
The eosinophilia myalgia syndrome: to be or not to be. (9213375)
1997
24
Eosinophilia-myalgia syndrome, eosinophilic fasciitis, and related fibrosing disorders. (9375286)
1997
25
Elevated L-kynurenine level and its normalization by prednisolone in a patient with eosinophilia-myalgia syndrome. (9037890)
1997
26
Eosinophilia myalgia syndrome. (9213377)
1997
27
Eosinophilia-myalgia syndrome: description of an unusual case. (9196880)
1997
28
Eosinophilia-myalgia syndrome: opportunities realized and missed. (9195545)
1997
29
On-line HPLC-tandem mass spectrometry analysis of contaminants of L-tryptophan associated with the onset of the eosinophilia-myalgia syndrome. (9295237)
1997
30
Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. (9076948)
1997
31
Cognitive deficits in a murine model of the eosinophilia-myalgia syndrome: a preliminary report. (8888024)
1996
32
Analysis of Centers for Disease Control and Prevention criteria for the eosinophilia-myalgia syndrome in a geographically defined population. (8895183)
1996
33
Eosinophilia-myalgia syndrome. Status of patients at onset and after four years of disease. (8906291)
1996
34
A comparative study of tissue distribution and excretion among three substances implicated in eosinophilia-myalgia syndrome. (8906290)
1996
35
Eosinophilia-myalgia syndrome: patient status 2-4 years after onset. (8895178)
1996
36
A diagnostic algorithm for distinguishing the eosinophilia-myalgia syndrome from fibromyalgia and chronic myofascial pain. (8895177)
1996
37
Eosinophilia-myalgia syndrome among the non-L-tryptophan users and pre-epidemic cases. (8895159)
1996
38
1995 Bailey K. Ashford lecture. Public health lessons from two catastrophic epidemics: the toxic oil syndrome and the eosinophilia-myalgia syndrome. (8744866)
1996
39
Pathophysiology of the eosinophilia-myalgia syndrome. (8895179)
1996
40
Effect of L-tryptophan products on function of human eosinophils: investigation of the causal mechanisms of eosinophilia myalgia syndrome associated with L-tryptophan products. (8906111)
1996
41
Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. (8895184)
1996
42
EBT, a tryptophan contaminant associated with eosinophilia myalgia syndrome, is incorporated into proteins during translation as an amino acid analog. (9161698)
1996
43
Delayed onset of skin fibrosis after the ingestion of eosinophilia-myalgia syndrome-associated L-tryptophan. (8708033)
1996
44
Pathogenesis of L-tryptophan eosinophilia myalgia syndrome. (8906284)
1996
45
The eosinophilia-myalgia syndrome: what we know, what we think we know, and what we need to know. (8895175)
1996
46
Persistent microvasculopathy in chronic eosinophilia-myalgia syndrome. (8906289)
1996
47
Epidemiologic studies of the association of L-tryptophan with the eosinophilia-myalgia syndrome: a critique. (8895181)
1996
48
Effects of tryptophan related compounds on nuclear regulatory control. Possible role in the eosinophilia-myalgia syndrome. (8906287)
1996
49
Eosinophilia-Myalgia Syndrome: Review and Reappraisal of Clinical, Epidemiologic and Animal Studies Symposium. Washington, D.C., USA, December 7-8, 1994. Proceedings. (9053528)
1996
50
Animal models of the eosinophilia-myalgia syndrome. (8895185)
1996

Variations for Eosinophilia-Myalgia Syndrome

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Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

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Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

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Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathwaysScoreTop Affiliating Genes
19.6IFNG, IL5
29.6IFNG, IL5
39.6IFNG, IL5
49.5HLA-DQA1, HLA-DRB1
59.5HLA-DQA1, HLA-DRB1
69.5HLA-DRB1, IFNG
79.5AHR, IFNG
89.4IDO1, IFNG
99.2HLA-DQA1, HLA-DRB1, IL5
109.1HLA-DRB1, IFNG, IL5
119.1AHR, IFNG, IL5
129.1AHR, IFNG, IL5
13
Show member pathways
9.1HLA-DQA1, HLA-DRB1, IFNG
14
Show member pathways
9.1HLA-DQA1, HLA-DRB1, IFNG
159.1HLA-DQA1, HLA-DRB1, IFNG
169.1HLA-DQA1, HLA-DRB1, IFNG
179.1HLA-DQA1, HLA-DRB1, IFNG
18
Show member pathways
9.1HLA-DQA1, HLA-DRB1, IFNG
19
Show member pathways
8.7HLA-DQA1, HLA-DRB1, IFNG, IL5
20
Show member pathways
8.2AHR, HLA-DQA1, HLA-DRB1, IFNG, IL5

GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

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Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:003066910.1HLA-DQA1, HLA-DRB1
2endocytic vesicle membraneGO:003066610.1HLA-DQA1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:001250710.1HLA-DQA1, HLA-DRB1
4integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.0HLA-DQA1, HLA-DRB1
5MHC class II protein complexGO:004261310.0HLA-DQA1, HLA-DRB1
6transport vesicle membraneGO:00306589.5HLA-DQA1, HLA-DRB1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:000250410.2HLA-DQA1, HLA-DRB1
2positive regulation of interleukin-12 productionGO:003273510.0IDO1, IFNG
3negative regulation of T cell proliferationGO:00421309.9HLA-DRB1, IDO1
4antigen processing and presentationGO:00198829.8HLA-DQA1, HLA-DRB1, IFNG
5interferon-gamma-mediated signaling pathwayGO:00603339.7HLA-DQA1, HLA-DRB1, IFNG
6immune responseGO:00069559.3HLA-DQA1, HLA-DRB1, IFNG, IL5
7T cell receptor signaling pathwayGO:00508529.1HLA-DQA1, HLA-DRB1, IFNG

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.9HLA-DQA1, HLA-DRB1
2peptide antigen bindingGO:00426059.5HLA-DQA1, HLA-DRB1

Sources for Eosinophilia-Myalgia Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet