MCID: ESN002
MIFTS: 45

Eosinophilia-Myalgia Syndrome malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

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Aliases & Descriptions for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 11 46 13 48 37 66
Ems 46 2
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 46
 
Severe Muscle Pain and Abnormally High Eosinophils 46
Eosinophilia Myalgia Syndrome 11
L-Tryptophan Induced Ems 46

Classifications:



External Ids:

Disease Ontology11 DOID:998
ICD9CM30 710.5
SNOMED-CT60 95416007
MeSH37 D016603

Summaries for Eosinophilia-Myalgia Syndrome

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CDC:2 Emergency medical services (EMS) workers provide pre-hospital emergency medical care. Their duties create an inherent risk for on-the-job injuries and illnesses. Research shows that EMS workers have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary: Eosinophilia-Myalgia Syndrome, also known as ems, is related to eosinophilia and toxic oil syndrome, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways are IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and IgA-Producing B Cells in the Intestine. Affiliated tissues include skin, heart and lung, and related mouse phenotypes are liver/biliary system and neoplasm.

Wikipedia:69 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

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Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia11.2
2toxic oil syndrome10.6
3fasciitis10.6
4vibrio vulnificus infection10.5IL5, TGFB1
5crustacean allergy10.5IL5, TGFB1
6eosinophilic fasciitis10.4
7parsonage turner syndrome10.4HLA-DQA1, TGFB1
8myopathy-growth delay-intellectual disability-hypospadias syndrome10.4HLA-DQA1, TGFB1
9peanut allergy10.4IL5, TGFB1
10loin pain hematuria syndrome10.4IL5, TGFB1
11thomsen and becker disease10.4IFNG, IL5
12gonococcal synovitis10.4IFNG, IL5
13acute gonococcal salpingitis10.4IFNG, IL5
14opiate dependence10.4IFNG, IL5
15cervix melanoma10.4IFNG, IL5
16idiopathic neutropenia10.4IFNG, IL5
17buphthalmos10.4IFNG, IL5
18synostosis10.3IL5, TGFB1
19aseptic osteitis10.3HLA-DQA1, IFNG
20duodenal benign neoplasm10.3HLA-DQA1, IFNG
21x-linked intellectual disability, siderius type10.3IFNG, IL5
22multicentric castleman disease10.3HLA-DQA1, IFNG
23keratopathy10.3IFNG, TGFB1
24reproductive system disease10.3IFNG, IL5
25compensatory emphysema10.3HLA-DQA1, IFNG
26addison's disease10.3IFNG, TGFB1
27sarcoid meningitis10.3IFNG, IL5
28bile duct signet ring cell carcinoma10.3HLA-DQA1, IFNG
29wissler's syndrome10.3IFNG, IL5
30orbital lymphangioma10.3IFNG, TGFB1
31granulomatous endometritis10.3IDO1, IL5
32intrinsic cardiomyopathy10.3HLA-DQA1, IFNG
33dengue disease10.3IFNG, IL5
34gastric ulcer10.3IFNG, IL5
35malignant neoplasm of acoustic nerve10.3IFNG, TGFB1
36binocular vision disease10.3IFNG, TGFB1
37exophthalmos10.3IFNG, IL5
38polyneuropathy10.3
39louping ill10.3IFNG, TGFB1
40conventional malignant hemangiopericytoma10.3IFNG, IL5
41esophagus melanoma10.2IFNG, TGFB1
42secondary lacrimal atrophy10.2IFNG, TGFB1
43burn scar10.2IFNG, TGFB1
44bolivian hemorrhagic fever10.2HNMT, IFNG
45myopathy10.2
46neuropathy10.2
47lung sarcoma10.2IFNG, IL5
48paranasal sinus sarcoma10.2IFNG, TGFB1
49sternum lymphoma10.2HLA-DQA1, IFNG
50alternating exotropia10.2IFNG, IL5

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Symptoms for Eosinophilia-Myalgia Syndrome

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UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


muscle cramp, muscle rigidity, muscle spasticity, pain, muscle weakness, myalgia

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

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Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
15-hydroxytryptophan11

Interventional clinical trials:

idNameStatusNCT IDPhase
1L-5-HTP-Related EMSCompletedNCT00001918
2Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical TrialsCompletedNCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome


Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

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Anatomical Context for Eosinophilia-Myalgia Syndrome

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MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

34
Skin, Heart, Lung, Brain, T cells, Neutrophil, Liver

Animal Models for Eosinophilia-Myalgia Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Eosinophilia-Myalgia Syndrome:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6AHR, IFNG, IL5, TGFB1
2MP:00020068.0AHR, IFNG, IL5, TGFB1
3MP:00053897.6AHR, IDO1, IFNG, IL5, TGFB1
4MP:00053877.4AHR, HLA-DQA1, IDO1, IFNG, IL5, TGFB1
5MP:00053977.3AHR, HLA-DQA1, IDO1, IFNG, IL5, TGFB1

Publications for Eosinophilia-Myalgia Syndrome

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Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 338)
idTitleAuthorsYear
1
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? (19941898)
2010
2
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. (17806156)
2007
3
Is there any relationship between eosinophilia myalgia syndrome (EMS) and fibromyalgia syndrome (FMS)? An analysis of clinical and immunological data. (10721092)
1999
4
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome. (9817085)
1998
5
Eosinophilia myalgia syndrome. (9213377)
1997
6
Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. (8895184)
1996
7
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
8
Eosinophilia-myalgia syndrome: a long-term follow-up study. (7660215)
1995
9
Psychiatric aspects of the eosinophilia-myalgia syndrome. (7871130)
1995
10
Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome. (7955801)
1994
11
The eosinophilia-myalgia syndrome: lessons from Germany. (8015338)
1994
12
Eosinophilia myalgia syndrome: absence of immunoglobulin reactivity suggests a cellular rather than humoral mechanism. (7976226)
1994
13
A murine model of the eosinophilia-myalgia syndrome induced by 1,1'-ethylidenebis (L-tryptophan). (8163652)
1994
14
Toxic oil syndrome and eosinophilia myalgia syndrome: similar, different or the same disorder? (7699614)
1994
15
Production of polyclonal antibodies against 1,1'-ethyliden bis[L-tryptophan] (EBT), a potential contaminant causing eosinophilia-myalgia syndrome (EMS). (8475503)
1993
16
Eosinophilia-myalgia syndrome and fasciitis with an active alveolitis. (8355447)
1993
17
Eosinophilia-myalgia syndrome: morbidity and mortality. (8295172)
1993
18
3-(Phenylamino)alanine--a link between eosinophilia-myalgia syndrome and toxic oil syndrome? (8423703)
1993
19
Use of cyclosporin A in the eosinophilia myalgia syndrome. (8427523)
1993
20
Identification of decomposition products of 1,1'-ethylidenebis [L-tryptophan], a compound associated with eosinophilia-myalgia syndrome. (1504513)
1992
21
Episodic angioedema with eosinophilia versus eosinophilia-myalgia syndrome. (1583248)
1992
22
Chronic demyelinating polyneuropathy associated with eosinophilia-myalgia syndrome. (1534836)
1992
23
Eosinophilia-myalgia syndrome: the aftermath. (1523446)
1992
24
Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome. (1418026)
1992
25
3-(Phenylamino)alanine, a novel aniline-derived amino acid associated with the eosinophilia-myalgia syndrome: a link to the toxic oil syndrome? (1469924)
1992
26
Eosinophilia-myalgia syndrome in L-tryptophan-exposed patients. (1727200)
1992
27
Serum cytokines and the eosinophilia myalgia syndrome. (1463513)
1992
28
Gastrointestinal involvement in L-tryptophan (L-Trp) associated eosinophilia-myalgia syndrome (EMS). (1563309)
1992
29
Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1929872)
1991
30
Environmental pathology. Mast cell and eosinophil infiltration in intestinal mucosa of Lewis rats treated with L-tryptophan implicated in human eosinophilia myalgia syndrome. (2068062)
1991
31
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (1984598)
1991
32
L-tryptophan-induced eosinophilia-myalgia syndrome. (1829754)
1991
33
Eosinophilia-myalgia syndrome. A clinical case series of 21 patients. New Mexico Eosinophilia-Myalgia Syndrome Study Group. (2001136)
1991
34
Effect of synthesized constituents in the L-tryptophan product on the differentiation of eosinophils and the induction of IL-6: a possible cause of eosinophilia-myalgia syndrome. (1872826)
1991
35
Eosinophilia-myalgia syndrome. (2027503)
1991
36
L-tryptophan-induced eosinophilia-myalgia syndrome. II. Partial correction of abnormal tryptophan metabolism by pyridoxine. (1722762)
1991
37
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
38
The eosinophilia-myalgia syndrome. (2339858)
1990
39
Eosinophilia-myalgia syndrome: unresolved questions. (2372919)
1990
40
Peripheral neuropathy in the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. (2162498)
1990
41
L-tryptophan induced eosinophilia-myalgia syndrome. (2273498)
1990
42
The eosinophilia-myalgia syndrome with neuritis associated with L-tryptophan use. (2339856)
1990
43
From the Centers for Disease Control. Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States, as of January 9, 1990. (2296113)
1990
44
Tryptophan and eosinophilia myalgia syndrome. (2244397)
1990
45
Eosinophilia-myalgia syndrome--Canada. (2282665)
1990
46
From the Centers for Disease Control. Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome. (2169007)
1990
47
Eosinophilia myalgia syndrome. (2385394)
1990
48
Eosinophilia-myalgia syndrome--New Mexico. (2509886)
1989
49
Eosinophilia-myalgia syndrome and L-tryptophan-containing products--New Mexico, Minnesota, Oregon, and New York, 1989. (2509891)
1989
50
Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States. (2511412)
1989

Variations for Eosinophilia-Myalgia Syndrome

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Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

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Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

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Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathwaysScoreTop Affiliating Genes
19.6IL5, TGFB1
29.6IL5, TGFB1
39.6IFNG, IL5
49.6IFNG, IL5
59.6IFNG, IL5
69.5IFNG, TGFB1
79.5IFNG, TGFB1
89.5IFNG, TGFB1
9
Show member pathways
9.5IFNG, TGFB1
109.5IFNG, TGFB1
119.3IDO1, IFNG
12
Show member pathways
9.1IFNG, IL5, TGFB1
139.1IFNG, IL5, TGFB1
14
Show member pathways
9.1IFNG, IL5, TGFB1
15
Show member pathways
9.1HLA-DQA1, IFNG, TGFB1
169.1HLA-DQA1, IFNG, TGFB1
179.1HLA-DQA1, IFNG, TGFB1
188.8AHR, IFNG, IL5
19
Show member pathways
8.7HLA-DQA1, IFNG, IL5, TGFB1

GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

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Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-17 productionGO:003270010.1IFNG, TGFB1
2interferon-gamma-mediated signaling pathwayGO:006033310.1HLA-DQA1, IFNG
3protein import into nucleus, translocationGO:000006010.0IFNG, TGFB1
4extrinsic apoptotic signaling pathwayGO:009719110.0IFNG, TGFB1
5positive regulation of interleukin-12 productionGO:00327359.9IDO1, IFNG
6response to immobilization stressGO:00359029.8HNMT, TGFB1
7negative regulation of T cell proliferationGO:00421309.5IDO1, TGFB1
8inflammatory responseGO:00069549.3IDO1, IL5, TGFB1
9positive regulation of apoptotic processGO:00430658.9IDO1, IFNG, TGFB1
10positive regulation of transcription, DNA-templatedGO:00458938.0AHR, IFNG, IL5, TGFB1

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IFNG, IL5, TGFB1

Sources for Eosinophilia-Myalgia Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet