EMS
MCID: ESN002
MIFTS: 47

Eosinophilia-Myalgia Syndrome (EMS) malady

Rare diseases, Blood diseases categories

Summaries for Eosinophilia-Myalgia Syndrome

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Eosinophilia?myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological condition... more...

MalaCards: Eosinophilia-Myalgia Syndrome, also known as syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart, is related to eosinophilia and eosinophilic fasciitis. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Hematopoietic cell lineage and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. The compounds toluene diisocyanate and dpa 1 have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung.

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

About this section
Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 36MeSH, 59SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

eosinophilia-myalgia syndrome 9 44 11 46 63
syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart 44
severe muscle pain and abnormally high eosinophils 44
eosinophilia myalgia syndrome 9
l-tryptophan induced ems 44
ems 44


External Ids:

Disease Ontology9 DOID:998
ICD9CM28 710.5
SNOMED-CT59 95416007
MeSH36 D016603

Related Diseases for Eosinophilia-Myalgia Syndrome

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Symptoms for Eosinophilia-Myalgia Syndrome

About this section

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Eosinophilia-Myalgia Syndrome

Drug clinical trials:

Search ClinicalTrials for Eosinophilia-Myalgia Syndrome

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Search CenterWatch for Eosinophilia-Myalgia Syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

About this section

Anatomical Context for Eosinophilia-Myalgia Syndrome

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

34
Skin, Heart, Lung, Brain, Spinal cord, Skeletal muscle, Liver, T cells

Animal Models for Eosinophilia-Myalgia Syndrome or affiliated genes

About this section

Publications for Eosinophilia-Myalgia Syndrome

About this section
Sources:
53PubMed
See all sources

Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 336)
idTitleAuthorsYear
1
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? (19941898)
2010
2
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. (17806156)
2007
3
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. (17892268)
2007
4
Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. (10606395)
1999
5
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome. (9817085)
1998
6
Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. (9076948)
1997
7
The eosinophilia-myalgia syndrome and the toxic oil syndrome. Pursuing parallels. (8906286)
1996
8
1995 Bailey K. Ashford lecture. Public health lessons from two catastrophic epidemics: the toxic oil syndrome and the eosinophilia-myalgia syndrome. (8744866)
1996
9
1,1'-Ethylidenebis[L-tryptophan], an impurity in L-tryptophan associated with eosinophilia-myalgia syndrome, stimulates type I collagen gene expression in human fibroblasts in vitro. (8624499)
1995
10
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
11
Eosinophilia-myalgia syndrome: a long-term follow-up study. (7660215)
1995
12
P-31 magnetic resonance spectroscopy of skeletal muscle in the eosinophilia-myalgia syndrome: a preliminary study. (8035389)
1994
13
Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome. (7955801)
1994
14
The eosinophilia-myalgia syndrome: lessons from Germany. (8015338)
1994
15
Studies with 1,1'-ethylidenebis(tryptophan), a contaminant associated with L-tryptophan implicated in the eosinophilia-myalgia syndrome. (8184420)
1994
16
Eosinophilia myalgia syndrome: absence of immunoglobulin reactivity suggests a cellular rather than humoral mechanism. (7976226)
1994
17
Eosinophilia-myalgia syndrome in Germany: an epidemiologic review. (8015323)
1994
18
Production of polyclonal antibodies against 1,1'-ethyliden bis[L-tryptophan] (EBT), a potential contaminant causing eosinophilia-myalgia syndrome (EMS). (8475503)
1993
19
Eosinophilia-myalgia syndrome and fasciitis with an active alveolitis. (8355447)
1993
20
Toxic oil syndrome and eosinophilia-myalgia syndrome: May 8-10, 1991, World Health Organization meeting report. (8266108)
1993
21
The eosinophilia-myalgia syndrome: current concepts and future directions. (1551286)
1992
22
Eosinophilia-myalgia syndrome. Natural history in a population-based cohort. (1520057)
1992
23
Eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1386918)
1992
24
Central nervous system involvement in the eosinophilia-myalgia syndrome. (1417516)
1992
25
Identification of decomposition products of 1,1'-ethylidenebis [L-tryptophan], a compound associated with eosinophilia-myalgia syndrome. (1504513)
1992
26
Episodic angioedema with eosinophilia versus eosinophilia-myalgia syndrome. (1583248)
1992
27
Chronic demyelinating polyneuropathy associated with eosinophilia-myalgia syndrome. (1534836)
1992
28
Eosinophilia-myalgia syndrome: the aftermath. (1523446)
1992
29
Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1929872)
1991
30
Environmental pathology. Mast cell and eosinophil infiltration in intestinal mucosa of Lewis rats treated with L-tryptophan implicated in human eosinophilia myalgia syndrome. (2068062)
1991
31
Eosinophilia-myalgia syndrome: the Cleveland Clinic experience. (1934454)
1991
32
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (1984598)
1991
33
L-tryptophan-induced eosinophilia-myalgia syndrome. (1829754)
1991
34
Postmortem studies of the heart in three fatal cases of the eosinophilia-myalgia syndrome. (2058857)
1991
35
Unraveling the eosinophilia-myalgia syndrome. (1863082)
1991
36
Eosinophilia-myalgia syndrome. A clinical case series of 21 patients. New Mexico Eosinophilia-Myalgia Syndrome Study Group. (2001136)
1991
37
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
38
Dermal mucinosis in the eosinophilia-myalgia syndrome. (2241211)
1990
39
The eosinophilia-myalgia syndrome. (2339858)
1990
40
Clinical spectrum of the systemic manifestations of the eosinophilia-myalgia syndrome. (2164712)
1990
41
Eosinophilia-myalgia syndrome: unresolved questions. (2372919)
1990
42
Peripheral neuropathy in the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. (2162498)
1990
43
L-tryptophan induced eosinophilia-myalgia syndrome. (2273498)
1990
44
Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome. (2166897)
1990
45
Eosinophilia-myalgia syndrome. Results of national surveillance. (2398610)
1990
46
The eosinophilia-myalgia syndrome with neuritis associated with L-tryptophan use. (2339856)
1990
47
Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States, as of January 9, 1990. (2104651)
1990
48
Eosinophilia-myalgia syndrome with myoclonic jerks. (2292676)
1990
49
The eosinophilia-myalgia syndrome. (2139551)
1990
50
Eosinophilia-myalgia syndrome--New Mexico. (2509886)
1989

Variations for Eosinophilia-Myalgia Syndrome

About this section

Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Eosinophilia-Myalgia Syndrome

Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

About this section
Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 61Thomson Reuters
See all sources

Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL5, HLA-DRB1
2
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.5IL5, IFNG
39.5IL5, IFNG
49.5IFNG, IL5
59.5IFNG, IL5
69.5IFNG, IL5
7
Show member pathways
9.5HLA-DQA1, HLA-DRB1
89.5HLA-DRB1, HLA-DQA1
9
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.5HLA-DRB1, HLA-DQA1
10
Show member pathways
9.5HLA-DRB1, HLA-DQA1
119.5HLA-DRB1, HLA-DQA1
129.4IFNG, IDO1
13
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.3IFNG, HLA-DRB1
149.3IFNG, HLA-DRB1
159.0IL5, IFNG, HLA-DRB1
16
Show member pathways
8.9HLA-DQA1, HLA-DRB1, IFNG
178.9HLA-DQA1, HLA-DRB1, IFNG
18
Show member pathways
8.9IFNG, HLA-DRB1, HLA-DQA1
198.9IFNG, HLA-DRB1, HLA-DQA1
20
Show member pathways
8.9IFNG, HLA-DRB1, HLA-DQA1
218.9IFNG, HLA-DRB1, HLA-DQA1
22
Show member pathways
8.5IL5, IFNG, HLA-DRB1, HLA-DQA1
23
Show member pathways
8.5IL5, IFNG, HLA-DRB1, HLA-DQA1
24
Show member pathways
8.5HLA-DQA1, HLA-DRB1, IFNG, IL5

Compounds for genes affiliated with Eosinophilia-Myalgia Syndrome

About this section
Sources:
46Novoseek, 62Tocris Bioscience, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB
See all sources

Compounds related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1toluene diisocyanate4610.2HNMT, IL5
2dpa 1469.9HLA-DQA1, HLA-DRB1
3pirfenidone46 6210.9IL5, IFNG
4amphotericin b469.9IL5, IFNG
5lapatinib46 52 1211.9HLA-DQA1, HLA-DRB1
6il-12469.9IFNG, IL5
7imiquimod46 62 30 1212.9IL5, IFNG
81-methyltryptophan469.9IDO1, IFNG
9con a469.9IL5, IFNG
103-hydroxyanthranilic acid46 2510.8IDO1, IFNG
11gm-csf46 3010.8IL5, IFNG
12kynurenine469.8IFNG, IDO1
13budesonide46 52 1211.8IFNG, IL5
14fluticasone propionate46 52 62 1212.8IL5, IFNG
15indoleamine469.8IFNG, IDO1
16polyinosinic-polycytidylic acid469.8IFNG, IL5
17rolipram46 62 3011.8IL5, IFNG
18methylcellulose469.8IFNG, IL5
19il 10469.8IL5, IFNG
20s-nitroso-n-acetylpenicillamine469.8IFNG, IDO1
212,5-oligoadenylate469.7IDO1, IFNG
22anti-fungal469.7IFNG, IL5
23gold sodium thiomalate469.7HLA-DRB1, IFNG
24tarc469.7IFNG, IL5
25l-nmma469.7IFNG, IDO1
26glucosamine46 25 1211.6IFNG, IL5
27infliximab46 52 1211.6IDO1, IFNG
28ivig469.6IFNG, IL5
29l-tryptophan52 30 46 25 1213.5IDO1, IFNG, IL5
30poly(i-c)469.5IL5, IFNG, IDO1
31thalidomide46 52 62 1212.5IL5, IFNG
32histamine46 30 2511.5IFNG, IL5, HNMT
33rantes469.5IL5, IFNG, IDO1
34glatiramer acetate46 1210.4IL5, IFNG, HLA-DRB1
35allergens469.4IL5, IFNG, HLA-DRB1
36neopterin469.3IDO1, IFNG
37pge2469.3IL5, IFNG, IDO1
38thymidine46 2510.1IL5, IFNG, IDO1
39cycloheximide468.8IL5, IFNG, IDO1
40arginine468.5HLA-DQA1, HLA-DRB1, IDO1, IFNG, IL5

GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.6HLA-DRB1, HLA-DQA1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.6HLA-DRB1, HLA-DQA1
3clathrin-coated endocytic vesicle membraneGO:0306699.6HLA-DRB1, HLA-DQA1
4transport vesicle membraneGO:0306589.5HLA-DQA1, HLA-DRB1
5endocytic vesicle membraneGO:0306669.5HLA-DRB1, HLA-DQA1
6ER to Golgi transport vesicle membraneGO:0125079.4HLA-DRB1, HLA-DQA1
7trans-Golgi network membraneGO:0325889.2HLA-DRB1, HLA-DQA1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:0327359.5IFNG, IDO1
2antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.5HLA-DRB1, HLA-DQA1
3T cell costimulationGO:0312959.4HLA-DRB1, HLA-DQA1
4T cell receptor signaling pathwayGO:0508529.2HLA-DRB1, HLA-DQA1
5immune responseGO:0069559.2HLA-DQA1, HLA-DRB1, IL5
6interferon-gamma-mediated signaling pathwayGO:0603339.0HLA-DQA1, HLA-DRB1, IFNG
7cytokine-mediated signaling pathwayGO:0192218.7IL5, IFNG, HLA-DRB1, HLA-DQA1

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.5HLA-DRB1, HLA-DQA1

Products for genes affiliated with Eosinophilia-Myalgia Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eosinophilia-Myalgia Syndrome

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet