MCID: ESN002
MIFTS: 41

Eosinophilia-Myalgia Syndrome malady

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Aliases & Classifications for Eosinophilia-Myalgia Syndrome

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Aliases & Descriptions for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 8 42 10 44 61
Ems 42 2
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 42
 
Severe Muscle Pain and Abnormally High Eosinophils 42
Eosinophilia Myalgia Syndrome 8
L-Tryptophan Induced Ems 42


Classifications:



External Ids:

Disease Ontology8 DOID:998
MeSH33 D016603
SNOMED-CT56 95416007
ICD9CM27 710.5

Summaries for Eosinophilia-Myalgia Syndrome

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CDC:2 Emergency medical services (EMS) workers are primary providers of pre-hospital emergency medical care and integral components of disaster response. The potentially hazardous job duties of EMS workers include lifting patients and equipment, treating patients with infectious illnesses, handling hazardous chemical and body substances, and participating in the emergency transport of patients in ground and air vehicles. These duties create an inherent risk for EMS worker occupational injuries and illnesses; and research has shown that they have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary: Eosinophilia-Myalgia Syndrome, also known as ems, is related to eosinophilia and eosinophilic fasciitis. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Hematopoietic cell lineage and OX40 Pathway. The compounds toluene diisocyanate and dpa 1 have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung.

Wikipedia:64 Eosinophilia?myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological condition... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

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Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Symptoms for Eosinophilia-Myalgia Syndrome

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Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

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Drug clinical trials:

Search ClinicalTrials for Eosinophilia-Myalgia Syndrome

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

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Anatomical Context for Eosinophilia-Myalgia Syndrome

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MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

31
Skin, Heart, Lung, Brain, Spinal cord, Skeletal muscle, Liver, T cells, Neutrophil

Animal Models for Eosinophilia-Myalgia Syndrome or affiliated genes

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Publications for Eosinophilia-Myalgia Syndrome

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Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 335)
idTitleAuthorsYear
1
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? (19941898)
2010
2
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. (17806156)
2007
3
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. (17892268)
2007
4
Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. (10606395)
1999
5
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome. (9817085)
1998
6
Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. (9076948)
1997
7
The eosinophilia-myalgia syndrome and the toxic oil syndrome. Pursuing parallels. (8906286)
1996
8
1995 Bailey K. Ashford lecture. Public health lessons from two catastrophic epidemics: the toxic oil syndrome and the eosinophilia-myalgia syndrome. (8744866)
1996
9
1,1'-Ethylidenebis[L-tryptophan], an impurity in L-tryptophan associated with eosinophilia-myalgia syndrome, stimulates type I collagen gene expression in human fibroblasts in vitro. (8624499)
1995
10
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
11
Eosinophilia-myalgia syndrome: a long-term follow-up study. (7660215)
1995
12
P-31 magnetic resonance spectroscopy of skeletal muscle in the eosinophilia-myalgia syndrome: a preliminary study. (8035389)
1994
13
Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome. (7955801)
1994
14
The eosinophilia-myalgia syndrome: lessons from Germany. (8015338)
1994
15
Studies with 1,1'-ethylidenebis(tryptophan), a contaminant associated with L-tryptophan implicated in the eosinophilia-myalgia syndrome. (8184420)
1994
16
Eosinophilia myalgia syndrome: absence of immunoglobulin reactivity suggests a cellular rather than humoral mechanism. (7976226)
1994
17
Eosinophilia-myalgia syndrome in Germany: an epidemiologic review. (8015323)
1994
18
Production of polyclonal antibodies against 1,1'-ethyliden bis[L-tryptophan] (EBT), a potential contaminant causing eosinophilia-myalgia syndrome (EMS). (8475503)
1993
19
Eosinophilia-myalgia syndrome and fasciitis with an active alveolitis. (8355447)
1993
20
Toxic oil syndrome and eosinophilia-myalgia syndrome: May 8-10, 1991, World Health Organization meeting report. (8266108)
1993
21
The eosinophilia-myalgia syndrome: current concepts and future directions. (1551286)
1992
22
Eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1386918)
1992
23
Central nervous system involvement in the eosinophilia-myalgia syndrome. (1417516)
1992
24
A histopathologic comparison of Shulman's syndrome (diffuse fasciitis with eosinophilia) and the fasciitis associated with the eosinophilia-myalgia syndrome. (1732344)
1992
25
Identification of decomposition products of 1,1'-ethylidenebis [L-tryptophan], a compound associated with eosinophilia-myalgia syndrome. (1504513)
1992
26
Episodic angioedema with eosinophilia versus eosinophilia-myalgia syndrome. (1583248)
1992
27
Chronic demyelinating polyneuropathy associated with eosinophilia-myalgia syndrome. (1534836)
1992
28
Eosinophilia-myalgia syndrome: the aftermath. (1523446)
1992
29
Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1929872)
1991
30
Environmental pathology. Mast cell and eosinophil infiltration in intestinal mucosa of Lewis rats treated with L-tryptophan implicated in human eosinophilia myalgia syndrome. (2068062)
1991
31
Eosinophilia-myalgia syndrome: the Cleveland Clinic experience. (1934454)
1991
32
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (1984598)
1991
33
L-tryptophan-induced eosinophilia-myalgia syndrome. (1829754)
1991
34
Postmortem studies of the heart in three fatal cases of the eosinophilia-myalgia syndrome. (2058857)
1991
35
Unraveling the eosinophilia-myalgia syndrome. (1863082)
1991
36
Eosinophilia-myalgia syndrome. A clinical case series of 21 patients. New Mexico Eosinophilia-Myalgia Syndrome Study Group. (2001136)
1991
37
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
38
Dermal mucinosis in the eosinophilia-myalgia syndrome. (2241211)
1990
39
The eosinophilia-myalgia syndrome. (2339858)
1990
40
Clinical spectrum of the systemic manifestations of the eosinophilia-myalgia syndrome. (2164712)
1990
41
Eosinophilia-myalgia syndrome: unresolved questions. (2372919)
1990
42
Peripheral neuropathy in the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. (2162498)
1990
43
L-tryptophan induced eosinophilia-myalgia syndrome. (2273498)
1990
44
Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome. (2166897)
1990
45
Eosinophilia-myalgia syndrome. Results of national surveillance. (2398610)
1990
46
The eosinophilia-myalgia syndrome with neuritis associated with L-tryptophan use. (2339856)
1990
47
Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States, as of January 9, 1990. (2104651)
1990
48
Eosinophilia-myalgia syndrome with myoclonic jerks. (2292676)
1990
49
The eosinophilia-myalgia syndrome. (2139551)
1990
50
Eosinophilia-myalgia syndrome--New Mexico. (2509886)
1989

Variations for Eosinophilia-Myalgia Syndrome

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Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

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Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

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Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL5, HLA-DRB1
29.5IL5, IFNG
3
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.5IL5, IFNG
49.5IFNG, IL5
59.5IFNG, IL5
69.5IFNG, IL5
7
Show member pathways
9.5HLA-DQA1, HLA-DRB1
89.5HLA-DRB1, HLA-DQA1
9
Show member pathways
Immune response IL 22 signaling pathway59
G protein signaling N RAS regulation pathway59
9.5HLA-DRB1, HLA-DQA1
10
Show member pathways
9.5HLA-DQA1, HLA-DRB1
119.5HLA-DQA1, HLA-DRB1
129.4IDO1, IFNG
139.3IFNG, HLA-DRB1
14
Show member pathways
Immune response IL 12 induced IFN gamma production59
9.3HLA-DRB1, IFNG
159.0IFNG, IL5, HLA-DRB1
168.9HLA-DRB1, HLA-DQA1, IFNG
178.9IFNG, HLA-DQA1, HLA-DRB1
188.9IFNG, HLA-DRB1, HLA-DQA1
19
Show member pathways
8.9IFNG, HLA-DRB1, HLA-DQA1
20
Show member pathways
8.9HLA-DRB1, IFNG, HLA-DQA1
21
Show member pathways
8.9HLA-DRB1, IFNG, HLA-DQA1
22
Show member pathways
8.5HLA-DQA1, HLA-DRB1, IFNG, IL5
23
Show member pathways
8.5HLA-DQA1, HLA-DRB1, IL5, IFNG
24
Show member pathways
8.5HLA-DRB1, IFNG, IL5, HLA-DQA1

Compounds for genes affiliated with Eosinophilia-Myalgia Syndrome

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Compounds related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 40)
idCompoundScoreTop Affiliating Genes
1toluene diisocyanate4410.2HNMT, IL5
2dpa 1449.9HLA-DQA1, HLA-DRB1
3pirfenidone44 6010.9IFNG, IL5
4amphotericin b449.9IFNG, IL5
5il-12449.9IL5, IFNG
6lapatinib44 50 1111.9HLA-DRB1, HLA-DQA1
7imiquimod44 60 28 1112.9IFNG, IL5
81-methyltryptophan449.9IDO1, IFNG
9gm-csf44 2810.9IL5, IFNG
103-hydroxyanthranilic acid44 2410.8IFNG, IDO1
11con a449.8IL5, IFNG
12kynurenine449.8IDO1, IFNG
13budesonide44 50 1111.8IL5, IFNG
14fluticasone propionate44 50 60 1112.8IL5, IFNG
15polyinosinic-polycytidylic acid449.8IFNG, IL5
16indoleamine449.8IFNG, IDO1
17rolipram44 60 2811.8IL5, IFNG
18methylcellulose449.8IFNG, IL5
19il 10449.8IL5, IFNG
20s-nitroso-n-acetylpenicillamine449.8IDO1, IFNG
212,5-oligoadenylate449.7IDO1, IFNG
22anti-fungal449.7IFNG, IL5
23gold sodium thiomalate449.7IFNG, HLA-DRB1
24tarc449.7IFNG, IL5
25l-nmma449.7IDO1, IFNG
26glucosamine44 24 1111.7IFNG, IL5
27ivig449.6IFNG, IL5
28infliximab44 50 1111.6IFNG, IDO1
29l-tryptophan50 28 44 24 1113.5IL5, IFNG, IDO1
30poly(i-c)449.5IL5, IFNG, IDO1
31thalidomide44 50 60 1112.5IL5, IFNG
32histamine44 28 2411.5IL5, IFNG, HNMT
33rantes449.5IL5, IDO1, IFNG
34glatiramer acetate44 1110.4IFNG, IL5, HLA-DRB1
35allergens449.4IFNG, IL5, HLA-DRB1
36neopterin449.3IDO1, IFNG
37pge2449.3IL5, IFNG, IDO1
38thymidine44 2410.1IDO1, IL5, IFNG
39cycloheximide448.8IL5, IFNG, IDO1
40arginine448.5HLA-DQA1, IDO1, IFNG, IL5, HLA-DRB1

GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

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Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.6HLA-DRB1, HLA-DQA1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.6HLA-DRB1, HLA-DQA1
3clathrin-coated endocytic vesicle membraneGO:00306699.6HLA-DRB1, HLA-DQA1
4transport vesicle membraneGO:00306589.5HLA-DQA1, HLA-DRB1
5endocytic vesicle membraneGO:00306669.5HLA-DRB1, HLA-DQA1
6ER to Golgi transport vesicle membraneGO:00125079.4HLA-DRB1, HLA-DQA1
7trans-Golgi network membraneGO:00325889.2HLA-DRB1, HLA-DQA1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-12 productionGO:00327359.5IFNG, IDO1
2antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.5HLA-DRB1, HLA-DQA1
3T cell costimulationGO:00312959.4HLA-DRB1, HLA-DQA1
4T cell receptor signaling pathwayGO:00508529.2HLA-DRB1, HLA-DQA1
5immune responseGO:00069559.2HLA-DQA1, HLA-DRB1, IL5
6interferon-gamma-mediated signaling pathwayGO:00603339.0HLA-DQA1, HLA-DRB1, IFNG
7cytokine-mediated signaling pathwayGO:00192218.7IL5, IFNG, HLA-DRB1, HLA-DQA1

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.5HLA-DRB1, HLA-DQA1

Sources for Eosinophilia-Myalgia Syndrome

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet