MCID: ESN002
MIFTS: 42

Eosinophilia-Myalgia Syndrome

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

MalaCards integrated aliases for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 12 50 52 42 14 69
Ems 50 3
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 50
Severe Muscle Pain and Abnormally High Eosinophils 50
Eosinophilia Myalgia Syndrome 12
L-Tryptophan Induced Ems 50

Classifications:



External Ids:

Disease Ontology 12 DOID:998
ICD9CM 35 710.5
MeSH 42 D016603
SNOMED-CT 64 95416007
UMLS 69 C0085179

Summaries for Eosinophilia-Myalgia Syndrome

CDC : 3 Emergency medical services (EMS) workers provide pre-hospital emergency medical care. Their duties create an inherent risk for on-the-job injuries and illnesses. Research shows that EMS workers have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary : Eosinophilia-Myalgia Syndrome, also known as ems, is related to fibrous histiocytoma and toxic oil syndrome, and has symptoms including muscle cramp, muscle rigidity and muscle spasticity. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs 5-hydroxytryptophan and Tryptophan have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung.

Wikipedia : 72 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological condition... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
id Related Disease Score Top Affiliating Genes
1 fibrous histiocytoma 30.3 IFNG IL5
2 toxic oil syndrome 10.5
3 pyridoxine deficiency 10.5 IL5 TGFB1
4 thrombophlebitis migrans 10.5 IL5 TGFB1
5 fasciitis 10.5
6 x-linked intellectual disability, van esch type 10.4 IFNG IL5
7 acute gonococcal prostatitis 10.4 IFNG IL5
8 hemangioma of spleen 10.4 IFNG IL5
9 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.4 IFNG IL5
10 anhidrosis 10.4 BMP6 TGFB1
11 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.4 IFNG IL5
12 plantar wart 10.4 IFNG TGFB1
13 chronic graft versus host disease 10.4 IFNG TGFB1
14 congenital methemoglobinemia 10.4 BMP6 TGFB1
15 ohdo syndrome, maat-kievit-brunner type 10.3 BMP6 TGFB1
16 acute necrotizing encephalopathy type 1 10.3 IFNG IL5
17 cranial nerve malignant neoplasm 10.3 IFNG TGFB1
18 conjunctival concretion 10.3 IL5 TGFB1
19 penis agenesis 10.3 HLA-DRB1 IL5
20 acute contagious conjunctivitis 10.3 IFNG IL5
21 eosinophilic fasciitis 10.3
22 abnormal retinal correspondence 10.3 IFNG IL5
23 rheumatic myocarditis 10.3 BMP6 TGFB1
24 corneal intraepithelial neoplasm 10.3 IFNG IL5
25 beare-stevenson cutis gyrata syndrome 10.3 BMP6 TGFB1
26 specific developmental disorder 10.3 HLA-DQA1 IFNG
27 breast hemangiopericytoma 10.2 HLA-DQA1 HLA-DRB1
28 gastric ulcer 10.2 IFNG IL5
29 fuchs' heterochromic uveitis 10.2 IFNG IL5
30 ovarian surface papilloma 10.2 HLA-DQA1 HLA-DRB1
31 kernicterus due to isoimmunization 10.2 HLA-DQA1 HLA-DRB1
32 balkan nephropathy 10.2 IFNG IL5
33 reardon wilson cavanagh syndrome 10.2 BMP6 IFNG
34 epidermolysis bullosa simplex superficialis 10.2 HLA-DRB1 TGFB1
35 churg-strauss syndrome 10.2 IFNG IL5
36 oculogyric crisis 10.2 HLA-DQA1 HLA-DRB1
37 anthracosilicosis 10.2 HLA-DRB1 IFNG
38 mosaic trisomy 1 10.2 HLA-DRB1 IFNG
39 iida kannari syndrome 10.2 HLA-DRB1 TGFB1
40 not otherwise specified 3-mga-uria type 10.2 BMP6 HLA-DRB1
41 lymphocytic colitis 10.2 HLA-DRB1 IFNG
42 dengue disease 10.1 IFNG IL5
43 polyneuropathy 10.1
44 papillary squamous carcinoma 10.1 HLA-DRB1 IFNG
45 malignant struma ovarii 10.1 BMP6 TGFB1
46 hepadnavirus infection 10.1 HLA-DRB1 IFNG
47 deafness, autosomal recessive 62 10.1 IFNG IL5
48 epidermolysis bullosa acquisita 10.1 HLA-DRB1 IFNG
49 myopathy 10.1
50 neuropathy 10.1

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to Eosinophilia-Myalgia Syndrome

Symptoms & Phenotypes for Eosinophilia-Myalgia Syndrome

UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


muscle cramp, muscle rigidity, muscle spasticity, muscle weakness, myalgia

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 5-hydroxytryptophan
2 Tryptophan Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 L-5-HTP-Related EMS Completed NCT00001918
2 Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical Trials Completed NCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

Anatomical Context for Eosinophilia-Myalgia Syndrome

MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

39
Skin, Heart, Lung, Brain, T Cells, Neutrophil, Liver

Publications for Eosinophilia-Myalgia Syndrome

Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50) (show all 338)
id Title Authors Year
1
Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan. ( 21702023 )
2011
2
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? ( 19941898 )
2010
3
Immunogenetic risk and protective factors for the development of L-tryptophan-associated eosinophilia-myalgia syndrome and associated symptoms. ( 19790128 )
2009
4
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. ( 17806156 )
2007
5
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. ( 17892268 )
2007
6
Calcinosis cutis in a patient with eosinophilia-myalgia syndrome: case report. ( 16838769 )
2006
7
A heretofore undisclosed crux of eosinophilia-myalgia syndrome: compromised histamine degradation. ( 16307217 )
2005
8
Non-L-tryptophan related eosinophilia-myalgia syndrome with hypoproteinemia and hypoalbuminemia. ( 12610828 )
2003
9
Rigorous new approach to constructing a gold standard for validating new diagnostic criteria, as exemplified by the eosinophilia-myalgia syndrome. ( 11606145 )
2001
10
Eosinophilic cholecystitis as a possible late manifestation of the eosinophilia-myalgia syndrome. ( 11147758 )
2000
11
Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. ( 10606395 )
1999
12
Structural characterization of case-associated contaminants peak C and FF in L-tryptophan implicated in eosinophilia-myalgia syndrome. ( 10721088 )
1999
13
Is there any relationship between eosinophilia myalgia syndrome (EMS) and fibromyalgia syndrome (FMS)? An analysis of clinical and immunological data. ( 10721092 )
1999
14
Eosinophilia-myalgia syndrome and giant cell myocarditis: a case report and therapeutic approach. ( 11720607 )
1999
15
Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan. ( 10721089 )
1999
16
Structural characterization of contaminants found in commercial preparations of melatonin: similarities to case-related compounds from L-tryptophan associated with eosinophilia-myalgia syndrome. ( 9544622 )
1998
17
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome. ( 9817085 )
1998
18
Rapid HPLC screening method for contaminants found in implicated L-tryptophan associated with eosinophilia myalgia syndrome and adulterated rapeseed oil associated with toxic oil syndrome. ( 9787895 )
1998
19
Neurologic, MR imaging, and MR spectroscopic findings in eosinophilia myalgia syndrome. ( 9802492 )
1998
20
Pain, fatigue, and sleep in eosinophilia-myalgia syndrome: relationship to neuropsychological performance. ( 9706542 )
1998
21
L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia. ( 9858150 )
1998
22
Eosinophilia myalgia syndrome. ( 9213377 )
1997
23
On-line HPLC-tandem mass spectrometry analysis of contaminants of L-tryptophan associated with the onset of the eosinophilia-myalgia syndrome. ( 9295237 )
1997
24
Elevated L-kynurenine level and its normalization by prednisolone in a patient with eosinophilia-myalgia syndrome. ( 9037890 )
1997
25
Eosinophilia-myalgia syndrome: opportunities realized and missed. ( 9195545 )
1997
26
Eosinophilia-myalgia syndrome: description of an unusual case. ( 9196880 )
1997
27
Eosinophilia-myalgia syndrome, eosinophilic fasciitis, and related fibrosing disorders. ( 9375286 )
1997
28
Eosinophilia-myalgia syndrome: selective cognitive impairment, longitudinal effects, and neuroimaging findings. ( 9408106 )
1997
29
The eosinophilia myalgia syndrome: to be or not to be. ( 9213375 )
1997
30
Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. ( 9076948 )
1997
31
Cognitive deficits in a murine model of the eosinophilia-myalgia syndrome: a preliminary report. ( 8888024 )
1996
32
A diagnostic algorithm for distinguishing the eosinophilia-myalgia syndrome from fibromyalgia and chronic myofascial pain. ( 8895177 )
1996
33
Fibromyalgia, psychiatric disorders, and assessment of the longterm outcome of eosinophilia-myalgia syndrome. ( 8895180 )
1996
34
Effects of tryptophan related compounds on nuclear regulatory control. Possible role in the eosinophilia-myalgia syndrome. ( 8906287 )
1996
35
Delayed onset of skin fibrosis after the ingestion of eosinophilia-myalgia syndrome-associated L-tryptophan. ( 8708033 )
1996
36
Diagnostic bias in clinical decision making: an example of L-tryptophan and the diagnosis of eosinophilia-myalgia syndrome. ( 8970044 )
1996
37
Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. ( 8895184 )
1996
38
A comparative study of tissue distribution and excretion among three substances implicated in eosinophilia-myalgia syndrome. ( 8906290 )
1996
39
EBT, a tryptophan contaminant associated with eosinophilia myalgia syndrome, is incorporated into proteins during translation as an amino acid analog. ( 9161698 )
1996
40
Eosinophilia-myalgia syndrome among the non-L-tryptophan users and pre-epidemic cases. ( 8895159 )
1996
41
Pathogenesis of L-tryptophan eosinophilia myalgia syndrome. ( 8906284 )
1996
42
A contaminant of L-tryptophan enhances expression of dermal collagen in a murine model of eosinophilia myalgia syndrome. ( 8863345 )
1996
43
Clinical features of eosinophilia myalgia syndrome and related disorders. ( 8906285 )
1996
44
Eosinophilia-myalgia syndrome: patient status 2-4 years after onset. ( 8895178 )
1996
45
Eosinophilia myalgia syndrome. The role of contaminants, the role of serotonergic metabolism set up. ( 8906288 )
1996
46
Eosinophilia-Myalgia Syndrome: Review and Reappraisal of Clinical, Epidemiologic and Animal Studies Symposium. Washington, D.C., USA, December 7-8, 1994. Proceedings. ( 9053528 )
1996
47
The eosinophilia-myalgia syndrome: what we know, what we think we know, and what we need to know. ( 8895175 )
1996
48
Effect of L-tryptophan products on function of human eosinophils: investigation of the causal mechanisms of eosinophilia myalgia syndrome associated with L-tryptophan products. ( 8906111 )
1996
49
1995 Bailey K. Ashford lecture. Public health lessons from two catastrophic epidemics: the toxic oil syndrome and the eosinophilia-myalgia syndrome. ( 8744866 )
1996
50
Bias or biology: evaluating the epidemiologic studies of L-tryptophan and the eosinophilia-myalgia syndrome. ( 8895182 )
1996

Variations for Eosinophilia-Myalgia Syndrome

Expression for Eosinophilia-Myalgia Syndrome

Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for Eosinophilia-Myalgia Syndrome

Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
2
Show member pathways
12.46 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
3
Show member pathways
12.26 HLA-DQA1 HLA-DRB1 IFNG
4
Show member pathways
12.15 IFNG IL5 TGFB1
5 12.14 HLA-DQA1 HLA-DRB1 TGFB1
6
Show member pathways
12.09 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
7 11.99 HLA-DQA1 HLA-DRB1 IFNG
8
Show member pathways
11.98 HLA-DQA1 HLA-DRB1 IFNG TGFB1
9 11.92 HLA-DQA1 HLA-DRB1 IFNG TGFB1
10 11.62 HLA-DQA1 HLA-DRB1 IL5
11
Show member pathways
11.54 HLA-DQA1 HLA-DRB1
12 11.53 BMP6 IFNG TGFB1
13 11.45 BMP6 TGFB1
14 11.43 IL5 TGFB1
15 11.39 IFNG TGFB1
16 11.37 HLA-DQA1 HLA-DRB1
17 11.3 IFNG TGFB1
18 11.29 IFNG TGFB1
19 11.27 IFNG IL5
20 11.21 HLA-DQA1 HLA-DRB1 IFNG TGFB1
21
Show member pathways
11.18 IFNG TGFB1
22 11.07 IFNG IL5
23 11.04 IFNG IL5
24 10.94 IFNG IL5
25 10.88 HLA-DRB1 IFNG TGFB1
26 10.65 IL5 TGFB1
27 10.4 HLA-DRB1 IFNG IL5 TGFB1

GO Terms for Eosinophilia-Myalgia Syndrome

Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQA1 HLA-DRB1
2 transport vesicle membrane GO:0030658 9.26 HLA-DQA1 HLA-DRB1
3 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQA1 HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQA1 HLA-DRB1
5 MHC class II protein complex GO:0042613 8.62 HLA-DQA1 HLA-DRB1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.75 BMP6 IL5 TGFB1
2 T cell receptor signaling pathway GO:0050852 9.61 HLA-DQA1 HLA-DRB1 IFNG
3 positive regulation of epithelial cell proliferation GO:0050679 9.58 BMP6 TGFB1
4 SMAD protein signal transduction GO:0060395 9.57 BMP6 TGFB1
5 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.56 BMP6 TGFB1
6 extrinsic apoptotic signaling pathway GO:0097191 9.55 IFNG TGFB1
7 positive regulation of protein secretion GO:0050714 9.54 BMP6 TGFB1
8 negative regulation of T cell proliferation GO:0042130 9.52 HLA-DRB1 TGFB1
9 positive regulation of bone mineralization GO:0030501 9.51 BMP6 TGFB1
10 protein import into nucleus, translocation GO:0000060 9.49 IFNG TGFB1
11 response to immobilization stress GO:0035902 9.48 HNMT TGFB1
12 positive regulation of protein complex assembly GO:0031334 9.46 IFNG TGFB1
13 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.37 HLA-DQA1 HLA-DRB1
14 interferon-gamma-mediated signaling pathway GO:0060333 9.33 HLA-DQA1 HLA-DRB1 IFNG
15 positive regulation of SMAD protein import into nucleus GO:0060391 9.32 BMP6 TGFB1
16 negative regulation of interleukin-17 production GO:0032700 9.26 IFNG TGFB1
17 antigen processing and presentation GO:0019882 9.13 HLA-DQA1 HLA-DRB1 IFNG
18 regulation of regulatory T cell differentiation GO:0045589 9.1 TGFB1
19 immune response GO:0006955 9.02 BMP6 HLA-DQA1 HLA-DRB1 IFNG IL5

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 BMP6 IL5 TGFB1
2 transforming growth factor beta receptor binding GO:0005160 9.32 BMP6 TGFB1
3 peptide antigen binding GO:0042605 9.26 HLA-DQA1 HLA-DRB1
4 MHC class II receptor activity GO:0032395 8.96 HLA-DQA1 HLA-DRB1
5 cytokine activity GO:0005125 8.92 BMP6 IFNG IL5 TGFB1

Sources for Eosinophilia-Myalgia Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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