EMS
MCID: ESN002
MIFTS: 51

Eosinophilia-Myalgia Syndrome (EMS) malady

Summaries for Eosinophilia-Myalgia Syndrome

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3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Emergency medical services (EMS) workers are primary providers of pre-hospital emergency medical care and integral components of disaster response. The potentially hazardous job duties of EMS workers include lifting patients and equipment, treating patients with infectious illnesses, handling hazardous chemical and body substances, and participating in the emergency transport of patients in ground and air vehicles. These duties create an inherent risk for EMS worker occupational injuries and illnesses; and research has shown that they have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards: Eosinophilia-Myalgia Syndrome, also known as syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart, is related to eosinophilia and pulmonary eosinophilia. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde and Cytokines and Inflammatory Response. The compounds indoleamine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung, and related mouse phenotypes are reproductive system and tumorigenesis.

Wikipedia:63 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological... more...

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

eosinophilia-myalgia syndrome 8 42 10 44 60
syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart 42
severe muscle pain and abnormally high eosinophils 42
eosinophilia myalgia syndrome 8
l-tryptophan induced ems 42
ems 42


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Disease Ontology8 DOID:998
ICD9CM27 710.5
SNOMED-CT56 95416007
MeSH34 D016603

Related Diseases for Eosinophilia-Myalgia Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Clinical Features for Eosinophilia-Myalgia Syndrome

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Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Eosinophilia-Myalgia Syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

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Anatomical Context for Eosinophilia-Myalgia Syndrome

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32MalaCards
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MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

32
Skin, Heart, Lung, Brain, Spinal cord, Skeletal muscle, Liver, T cells

Animal Models for Eosinophilia-Myalgia Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eosinophilia-Myalgia Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.5TGFB1, TYRP1
2MP:00020068.7IFNG, TYRP1, AHR, IL5, TGFB1
3MP:00107718.4IFNG, CRH, TYRP1, AHR, TDO2, TGFB1
4MP:00053978.0TGFB1, IL5, AHR, CRH, HLA-DQA1, IFNG
5MP:00053867.9IFNG, SCXB, CRH, TYRP1, IL5, TDO2
6MP:00053877.9IFNG, HLA-DQA1, CRH, AHR, IL5, TGFB1
7MP:00053767.8IDO1, IFNG, CRH, TYRP1, AHR, IL5

Publications for Eosinophilia-Myalgia Syndrome

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50PubMed
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Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 339)
idTitleAuthorsYear
1
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. (17806156)
2007
2
Rigorous new approach to constructing a gold standard for validating new diagnostic criteria, as exemplified by the eosinophilia-myalgia syndrome. (11606145)
2001
3
Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan. (10721089)
1999
4
Neurologic, MR imaging, and MR spectroscopic findings in eosinophilia myalgia syndrome. (9802492)
1998
5
Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. (9076948)
1997
6
Eosinophilia-myalgia syndrome among the non-L-tryptophan users and pre-epidemic cases. (8895159)
1996
7
Diagnostic bias in clinical decision making: an example of L-tryptophan and the diagnosis of eosinophilia-myalgia syndrome. (8970044)
1996
8
1,1'-Ethylidenebis[L-tryptophan], an impurity in L-tryptophan associated with eosinophilia-myalgia syndrome, stimulates type I collagen gene expression in human fibroblasts in vitro. (8624499)
1995
9
Eosinophilia myalgia syndrome: absence of immunoglobulin reactivity suggests a cellular rather than humoral mechanism. (7976226)
1994
10
Eosinophilia-myalgia syndrome in Germany: an epidemiologic review. (8015323)
1994
11
Magnesium deficiency in the eosinophilia-myalgia syndrome. Report of clinical and biochemical improvement with repletion. (7945497)
1994
12
Eosinophilia-myalgia syndrome and fasciitis with an active alveolitis. (8355447)
1993
13
3-(Phenylamino)alanine--a link between eosinophilia-myalgia syndrome and toxic oil syndrome? (8423703)
1993
14
L-tryptophan and eosinophilia-myalgia syndrome. (8329035)
1993
15
Persistent eosinophilia in 2 patients with eosinophilia-myalgia syndrome. (8216410)
1993
16
A decomposition product of a contaminant implicated in L-tryptophan eosinophilia myalgia syndrome affects spinal cord neuronal cell death and survival through stereospecific, maturation and partly interleukin-1-dependent mechanisms. (8355179)
1993
17
The eosinophilia-myalgia syndrome: current concepts and future directions. (1551286)
1992
18
Eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1386918)
1992
19
Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome. (1418026)
1992
20
Serum cytokines and the eosinophilia myalgia syndrome. (1463513)
1992
21
Pathologic manifestations of the eosinophilia myalgia syndrome: analysis of 11 cases. (1563745)
1992
22
The eosinophilia-myalgia syndrome and tryptophan. (1503805)
1992
23
Early impressions concerning actinomycetal infections that may play a role in the pathogenesis of eosinophilia-myalgia syndrome (EMS) and other 'new illnesses'. (1614356)
1992
24
Eosinophilia-myalgia syndrome in a child with phenylketonuria. (1408523)
1992
25
Absent neutrophil alkaline phosphatase in the eosinophilia myalgia syndrome associated with L-tryptophan use. (2012075)
1991
26
The eosinophilia-myalgia syndrome and related disorders. (1887155)
1991
27
Eosinophilic fasciitis is clinically distinguishable from the eosinophilia-myalgia syndrome and is not associated with L-tryptophan use. (2023221)
1991
28
Gallium uptake in eosinophilia myalgia syndrome. (1919750)
1991
29
A limited form of the eosinophilia-myalgia syndrome. (1879093)
1991
30
The eosinophilia-myalgia syndrome: the Los Alamos Conference. (1680191)
1991
31
Pulmonary hypertension in a patient with tryptophan-induced eosinophilia-myalgia syndrome. (1996600)
1991
32
Perimyositis with perineuritis and myofiber type grouping in the eosinophilia myalgia syndrome associated with tryptophan ingestion. (1996728)
1991
33
Tryptophan and eosinophilia-myalgia syndrome. (1900976)
1991
34
Natural history of the eosinophilia-myalgia syndrome. (1651673)
1991
35
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (2017099)
1991
36
L-tryptophan induced eosinophilia-myalgia syndrome. (2273498)
1990
37
Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome. (2166897)
1990
38
Eosinophilia-myalgia syndrome with myoclonic jerks. (2292676)
1990
39
The eosinophilia-myalgia-syndrome and L-tryptophan containing products: a case report and review of the literature. (2204559)
1990
40
From the Centers for Disease Control. Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome. (2169007)
1990
41
Two patients with eosinophilia myalgia syndrome associated with tryptophan. (2383703)
1990
42
L-tryptophan and eosinophilia-myalgia syndrome in New Mexico. (1969024)
1990
43
The cause of the eosinophilia-myalgia syndrome associated with tryptophan use. (2402265)
1990
44
Scleroderma and L-tryptophan: a possible explanation of the eosinophilia-myalgia syndrome. (2212143)
1990
45
Neuromuscular manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome. (2083154)
1990
46
L-tryptophan use and the eosinophilia-myalgia syndrome. (2080050)
1990
47
Eosinophilia-myalgia syndrome (L-tryptophan-associated neuromyopathy). (2234439)
1990
48
Eosinophilia-myalgia syndrome, L-tryptophan, and informed consent. (1977000)
1990
49
Eosinophilia-myalgia syndrome and L-tryptophan. (2234620)
1990
50
Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States. (2511412)
1989

Genetic Variations for Eosinophilia-Myalgia Syndrome

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Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilia-Myalgia Syndrome

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Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

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37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Eosinophilia-Myalgia Syndrome

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44Novoseek, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1indoleamine4410.6TDO2
2pge24410.5TGFB1
3gm-csf44 2811.5IFNG
4hydrocortisone44 2 59 1113.4CRH
5tranilast4410.4IFNG
6n-formylkynurenine4410.3TDO2, IDO1
7glutamate4410.3AHR
8toluene diisocyanate4410.2IL5, HNMT
91-methyltryptophan4410.2IFNG, IDO1
103-hydroxyanthranilic acid44 2411.1IDO1, IFNG
11kynurenine449.9TDO2, IFNG, IDO1
12poly(i-c)449.9IDO1, IFNG, IL5
135-hydroxytryptamine449.8IDO1, CRH, TDO2
14l-nmma449.8IDO1, IFNG, CRH
15il 10449.8TGFB1, IL5, IFNG
16sodium nitroprusside449.8TGFB1, IL5, CRH
17rantes449.8TGFB1, IFNG, IDO1
18il-12449.7IFNG, IL5
19serine449.7TGFB1, TDO2, TYRP1
20dpa 1449.7HLA-DQA1, HLA-DRB1
21gold sodium thiomalate449.7HLA-DRB1, IFNG
22l-tryptophan44 28 11 2412.7TDO2, IL5, IFNG, IDO1
23glatiramer acetate44 1110.6IFNG, HLA-DRB1, IL5
24herbimycin a44 5910.6IL5, AHR, IFNG
25aspartate449.5CRH, AHR, TDO2
26allergens449.5IL5, HLA-DRB1, IFNG
27carbon449.5TDO2, AHR, CRH
28indomethacin44 59 28 1112.5IFNG, CRH, IL5, TGFB1
29thyroxine44 2410.5CRH, AHR, IL5, TGFB1
30tacrolimus44 49 1111.4TGFB1, IL5, IFNG
31vitamin d449.4CRH, AHR, IL5, TGFB1
32methylcellulose449.4IFNG, AHR, IL5, TGFB1
33lapatinib44 49 1111.3HLA-DQA1, HLA-DRB1
34thymidine44 2410.3IDO1, IFNG, IL5, TGFB1
35histamine44 28 2411.2HNMT, IFNG, CRH, IL5, TGFB1
36sb 20358044 5910.1TGFB1, IL5, AHR, CRH, IFNG
37cysteine448.8IL5, AHR, TYRP1, CRH, IFNG
38adenylate448.8IL5, AHR, TYRP1, CRH
39dexamethasone44 49 28 1111.8IDO1, IFNG, CRH, AHR, IL5, TGFB1
40alanine448.7HLA-DRB1, CRH, AHR, TDO2, TGFB1
41oligonucleotide448.7TGFB1, TYRP1, HLA-DQA1, HLA-DRB1, IDO1
42arginine447.8TDO2, IDO1, IFNG, HLA-DRB1, HLA-DQA1, CRH

GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

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16Gene Ontology
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Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.3HLA-DQA1, HLA-DRB1
2clathrin-coated endocytic vesicle membraneGO:0306698.7TYRP1, HLA-DQA1, HLA-DRB1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1tryptophan catabolic process to kynurenineGO:01944110.1TDO2, IDO1
2tryptophan catabolic processGO:00656910.1TDO2, IDO1
3cellular response to dexamethasone stimulusGO:07154910.0CRH, TGFB1
4female pregnancyGO:0075659.7TGFB1, CRH, IDO1
5extrinsic apoptotic signaling pathwayGO:0971919.7TGFB1, IFNG
6positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.6CRH, HLA-DRB1
7protein import into nucleus, translocationGO:0000609.6TGFB1, IFNG
8regulation of cartilage developmentGO:0610359.5TGFB1, SCXA
9positive regulation of interleukin-12 productionGO:0327359.5IFNG, IDO1
10positive regulation of collagen biosynthetic processGO:0329679.3SCXA, TGFB1
11interferon-gamma-mediated signaling pathwayGO:0603339.2IFNG, HLA-DRB1, HLA-DQA1
12positive regulation of gene expressionGO:0106289.0TGFB1, CRH, SCXA
13cytokine-mediated signaling pathwayGO:0192218.9IL5, HLA-DQA1, HLA-DRB1, IFNG

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.0HLA-DQA1, HLA-DRB1
2protein heterodimerization activityGO:0469828.5TGFB1, AHR, TYRP1, SCXA

Products for genes affiliated with Eosinophilia-Myalgia Syndrome

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Sources for Eosinophilia-Myalgia Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet