MCID: ESN002
MIFTS: 43

Eosinophilia-Myalgia Syndrome malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

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Aliases & Descriptions for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 10 45 47 12 36 65
Ems 45 2
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 45
 
Severe Muscle Pain and Abnormally High Eosinophils 45
Eosinophilia Myalgia Syndrome 10
L-Tryptophan Induced Ems 45

Classifications:



External Ids:

Disease Ontology10 DOID:998
ICD9CM29 710.5
SNOMED-CT59 95416007
MeSH36 D016603
UMLS65 C0085179

Summaries for Eosinophilia-Myalgia Syndrome

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CDC:2 Emergency medical services (EMS) workers provide pre-hospital emergency medical care. Their duties create an inherent risk for on-the-job injuries and illnesses. Research shows that EMS workers have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary: Eosinophilia-Myalgia Syndrome, also known as ems, is related to bronchopulmonary dysplasia and asthma. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways are IgA-Producing B Cells in the Intestine and IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types. Affiliated tissues include heart, lung and skin, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Wikipedia:68 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

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Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Symptoms for Eosinophilia-Myalgia Syndrome

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Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

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Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
15-hydroxytryptophan11
2TryptophanNutraceutical54

Interventional clinical trials:

idNameStatusNCT IDPhase
1L-5-HTP-Related EMSCompletedNCT00001918
2Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical TrialsCompletedNCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome


Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

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Anatomical Context for Eosinophilia-Myalgia Syndrome

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MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

33
Heart, Lung, Skin, Bone, Endothelial, Brain, Breast

Animal Models for Eosinophilia-Myalgia Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Eosinophilia-Myalgia Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.0AHR, IFNG, IL5, TGFB1
2MP:00053678.7AHR, CRH, IFNG, TGFB1
3MP:00053708.5AHR, CRH, IFNG, IL5, TGFB1
4MP:00053888.4AHR, CRH, IFNG, IL5, TGFB1
5MP:00053898.0AHR, IDO1, IFNG, IL5, TGFB1
6MP:00053767.4AHR, CRH, IDO1, IFNG, IL5, TGFB1
7MP:00053977.4AHR, CRH, IDO1, IFNG, IL5, TGFB1
8MP:00053877.1AHR, CRH, IDO1, IFNG, IL5, TGFB1

Publications for Eosinophilia-Myalgia Syndrome

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Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 338)
idTitleAuthorsYear
1
Complications of Chronic Suppurative Otitis Media and Their Management: A Single Institution 12 Years Experience. (26693451)
2015
2
Rare coexistence of mediastinal hepatoid adenocarcinoma, idiopathic azoospermia and horseshoe kidney: a case report and review of the literature. (26617920)
2015
3
Downregulated CXCL12 expression in mesenchymal stem cells associated with severe aplastic anemia in children. (25118993)
2015
4
Fitz-Hugh-Curtis syndrome in a male patient due to urinary tract infection. (25986163)
2015
5
The Wnt/planar cell polarity signaling pathway contributes to the integrity of tight junctions in brain endothelial cells. (24346691)
2014
6
E-cadherin as an epithelial barrier protein in exhaled breath condensate. (25379974)
2014
7
Rare human nicotinic acetylcholine receptor I+4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors. (24385388)
2014
8
Borderline personality disorder among primary care depressive patients: A five-year study. (24268615)
2014
9
Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer. (24130837)
2013
10
Appropriate Modulation of Autophagy Sensitizes Malignant Peripheral Nerve Sheath Tumor Cells to Treatment With Imatinib Mesylate. (24136016)
2013
11
Omacetaxine mepesuccinate (synribo) - newly launched in chronic myeloid leukemia. (23875628)
2013
12
Enamel defects on the maxillary premolars in patients with cleft lip and/or palate: a retrospective case-control study. (24101590)
2013
13
Association of dietary patterns with insulin resistance and clinically silent carotid atherosclerosis in apparently healthy people. (24045794)
2013
14
Prognostic value of combined aquaporin 3 and aquaporin 5 overexpression in hepatocellular carcinoma. (24224160)
2013
15
On bioptic protocol after laparoscopic Nissen-Rossetti fundoplication in patients with Barrett's esophagus. (23232488)
2012
16
Augmented kinetic observational proptometry: an improved technique for clinical assessment of proptosis and enophthalmos. (22072198)
2011
17
Microcephaly-capillary malformation syndrome: a story of rapid emergence of a new recognizable entity. (21834052)
2011
18
Pregnancy with Friedreich ataxia: a retrospective review of medical risks and psychosocial implications. (20478553)
2010
19
A new basophil activation test using CD63 and CCR3 in allergy to antibiotics. (20082620)
2010
20
Zbtb20-induced CA1 pyramidal neuron development and area enlargement in the cerebral midline cortex of mice. (19955470)
2010
21
Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines. (20146079)
2010
22
LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model. (20133709)
2010
23
Nifedipine-induced acute generalized exanthematous pustulosis in a case of acute glomerulonephritis. (19584474)
2009
24
Neuroendocrine differentiation is involved in chemoresistance induced by EGF in prostate cancer cells. (19356736)
2009
25
Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension. (18258847)
2008
26
Genetics, biology and clinical management of myeloid cell primary immune deficiencies: chronic granulomatous disease and leukocyte adhesion deficiency. (17133097)
2007
27
Long-term bosentan in chronic thromboembolic pulmonary hypertension. (16699254)
2007
28
The multifunctional human p100 protein 'hooks' methylated ligands. (17632523)
2007
29
Indoleamine-2,3-dioxygenase modulation of allergic immune responses. (16476191)
2006
30
An unusual cause of anterior mediastinal mass: thymic hyperplasia resulting from Graves disease. (16755190)
2006
31
Rasagiline in the pharmacotherapy of Parkinson's disease--a review. (16197359)
2005
32
Increased plasma levels of urokinase plasminogen activator and matrix metalloproteinase-9 in nonsmall cell lung cancer patients. (15748604)
2005
33
Combined overexpression of EGFR and estrogen receptor alpha correlates with a poor outcome in lung cancer. (16334162)
2005
34
Cardiovascular effects of splenomegaly and splenectomy in beta-thalassemia. (15711802)
2005
35
Tuberous sclerosis with hypothyroidism and precocious puberty. (15080418)
2004
36
CRBP-III:lacZ expression pattern reveals a novel heterogeneity of vascular endothelial cells. (15493015)
2004
37
Synthesis of a radioactive thiol reagent, 1-S-[3H]carboxymethyl-dithiothreitol: identification of the phosphorylation sites by N-terminal peptide sequencing and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. (12842118)
2003
38
Fibrin monomer and fibrinopeptide B act additively to increase DNA synthesis in smooth muscle cells cultured from human saphenous vein. (11296341)
2001
39
Further studies on the role of phospholipids in determining the characteristics of mitochondrial binding sites for type I hexokinase. (11996095)
2000
40
Transcriptional activation of the F(1)F(0) ATP synthase alpha-subunit initiator element by USF2 is mediated by p300. (10434034)
1999
41
New procedures to measure synthase and phosphatase activities of bisphosphoglycerate mutase. Interest for development of therapeutic drugs. (9099261)
1997
42
Ophthalmic manifestations of Smith-Magenis syndrome. (8684798)
1996
43
Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho. (1379745)
1992
44
Nutritional support in chronic obstructive lung disease. (1519188)
1992
45
Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin. (1318302)
1992
46
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. (2470152)
1989
47
Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red-cell membrane. (3146980)
1988
48
A shortened beta-hexosaminidase alpha-chain in an Italian patient with infantile Tay-Sachs disease. (2954459)
1987
49
Afro-Americans and acute intermittent porphyria (AIP). (7450135)
1980
50
Purpura fulminans. (4936527)
1971

Variations for Eosinophilia-Myalgia Syndrome

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Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

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Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

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GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

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Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-17 productionGO:003270010.2IFNG, TGFB1
2positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.1IL5, TGFB1
3cell cycle arrestGO:000705010.1IFNG, TGFB1
4protein import into nucleus, translocationGO:000006010.0IFNG, TGFB1
5positive regulation of protein phosphorylationGO:00019349.9CRH, TGFB1
6extrinsic apoptotic signaling pathwayGO:00971919.9IFNG, TGFB1
7cellular response to dexamethasone stimulusGO:00715499.7CRH, TGFB1
8response to cocaineGO:00422209.4CRH, HNMT
9negative regulation of gene expressionGO:00106299.3CRH, IFNG, TGFB1
10response to drugGO:00424939.2CRH, IFNG, TGFB1
11inflammatory responseGO:00069549.0IDO1, IL5, TGFB1
12female pregnancyGO:00075659.0CRH, IDO1, TGFB1
13positive regulation of transcription, DNA-templatedGO:00458939.0AHR, IFNG, IL5, TGFB1
14positive regulation of gene expressionGO:00106288.8CRH, IFNG, TGFB1
15positive regulation of cell proliferationGO:00082848.6CRH, IFNG, IL5, TGFB1

Sources for Eosinophilia-Myalgia Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet