EMS
MCID: ESN002
MIFTS: 51

Eosinophilia-Myalgia Syndrome (EMS) malady

Summaries for Eosinophilia-Myalgia Syndrome

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3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Emergency medical services (EMS) workers are primary providers of pre-hospital emergency medical care and integral components of disaster response. The potentially hazardous job duties of EMS workers include lifting patients and equipment, treating patients with infectious illnesses, handling hazardous chemical and body substances, and participating in the emergency transport of patients in ground and air vehicles. These duties create an inherent risk for EMS worker occupational injuries and illnesses; and research has shown that they have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards: Eosinophilia-Myalgia Syndrome, also known as syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart, is related to eosinophilia and pulmonary eosinophilia. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde and Cytokines and Inflammatory Response. The compounds indoleamine and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung, and related mouse phenotypes are reproductive system and tumorigenesis.

Wikipedia:63 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological... more...

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

eosinophilia-myalgia syndrome 8 42 10 44 60
syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart 42
severe muscle pain and abnormally high eosinophils 42
eosinophilia myalgia syndrome 8
l-tryptophan induced ems 42
ems 42


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Disease Ontology8 DOID:998
ICD9CM27 710.5
SNOMED-CT56 95416007
MeSH34 D016603

Related Diseases for Eosinophilia-Myalgia Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Clinical Features for Eosinophilia-Myalgia Syndrome

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Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Search CenterWatch for Eosinophilia-Myalgia Syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

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Anatomical Context for Eosinophilia-Myalgia Syndrome

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32MalaCards
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MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

32
Skin, Heart, Lung, Brain, Spinal cord, Skeletal muscle, Liver, T cells

Animal Models for Eosinophilia-Myalgia Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eosinophilia-Myalgia Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.5TGFB1, TYRP1
2MP:00020068.7IFNG, TYRP1, AHR, IL5, TGFB1
3MP:00107718.4IFNG, CRH, TYRP1, AHR, TDO2, TGFB1
4MP:00053978.0TGFB1, IL5, AHR, CRH, HLA-DQA1, IFNG
5MP:00053867.9IFNG, SCXB, CRH, TYRP1, IL5, TDO2
6MP:00053877.9IFNG, HLA-DQA1, CRH, AHR, IL5, TGFB1
7MP:00053767.8IDO1, IFNG, CRH, TYRP1, AHR, IL5

Publications for Eosinophilia-Myalgia Syndrome

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50PubMed
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Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 339)
idTitleAuthorsYear
1
Eosinophilic cholecystitis as a possible late manifestation of the eosinophilia-myalgia syndrome. (11147758)
2000
2
Pain, fatigue, and sleep in eosinophilia-myalgia syndrome: relationship to neuropsychological performance. (9706542)
1998
3
The eosinophilia-myalgia syndrome: what we know, what we think we know, and what we need to know. (8895175)
1996
4
Effect of L-tryptophan products on function of human eosinophils: investigation of the causal mechanisms of eosinophilia myalgia syndrome associated with L-tryptophan products. (8906111)
1996
5
Psychiatric aspects of the eosinophilia-myalgia syndrome. (7871130)
1995
6
The eosinophilia-myalgia syndrome: status of 205 patients and results of treatment 2 years after onset. (7741371)
1995
7
Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome. (7955801)
1994
8
1,1'-Ethylidenebis(tryptophan) (Peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: association of eosinophilia-myalgia syndrome with a L-tryptophan contaminant. (8132737)
1994
9
1,1'-Ethylidenebis[L-tryptophan], a contaminant implicated in L-tryptophan eosinophilia myalgia syndrome, suppresses mRNA expression of hypothalamic corticotropin-releasing hormone in Lewis (LEW/N) rat brain. (8528886)
1994
10
L-tryptophan and the eosinophilia-myalgia syndrome: a clinical and laboratory study. (7892779)
1994
11
Identification of four metabolites of 3-(phenylamino)alanine, a constituent in L-tryptophan products implicated in eosinophilia-myalgia syndrome, in rats. (7802590)
1994
12
Eosinophilia-myalgia syndrome: a recent syndrome serving as an alert to new diseases ahead. (7824518)
1994
13
Toxic oil syndrome and eosinophilia-myalgia syndrome: May 8-10, 1991, World Health Organization meeting report. (8266108)
1993
14
Central nervous system inflammation in the eosinophilia-myalgia syndrome. (8428238)
1993
15
Neurocognitive dysfunction in the eosinophilia-myalgia syndrome. (8492948)
1993
16
Eosinophilia-myalgia syndrome: mortality data from the US national surveillance system. (8295183)
1993
17
Accumulation of 1-methyl-tetrahydro-beta-carboline-3-carboxylic acid in blood and organs of rat. A possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (8517786)
1993
18
Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan. (8435665)
1993
19
Chronic immune activation in the eosinophilia-myalgia syndrome. (8355725)
1993
20
Immune-mediated mechanisms and immune activation of fibroblasts in the pathogenesis of eosinophilia-myalgia syndrome induced by L-tryptophan. (8100551)
1993
21
Identification of decomposition products of 1,1'-ethylidenebis [L-tryptophan], a compound associated with eosinophilia-myalgia syndrome. (1504513)
1992
22
Eosinophilia-myalgia syndrome: the aftermath. (1523446)
1992
23
Eosinophilia-myalgia syndrome: myopathic electrodiagnostic characteristics. (1584247)
1992
24
Eosinophilia-myalgia syndrome: coming to grips with a new illness. (1289111)
1992
25
The cause and pathogenesis of the eosinophilia-myalgia syndrome. (1727618)
1992
26
Demyelinating polyneuropathy in eosinophilia-myalgia syndrome. (1323757)
1992
27
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (1984598)
1991
28
Unraveling the eosinophilia-myalgia syndrome. (1863082)
1991
29
Telogen effluvium associated with eosinophilia-myalgia syndrome. (1880238)
1991
30
Eosinophilia-myalgia syndrome associated with L-tryptophan. A case report with pulmonary manifestations and review of the literature. (1656679)
1991
31
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (1994219)
1991
32
Eosinophilia-myalgia syndrome: follow-up survey of patients--New York, 1990-1991. (2046646)
1991
33
Pulmonary involvement in the eosinophilia-myalgia syndrome. (1989790)
1991
34
Dermal mucinosis in the eosinophilia-myalgia syndrome. (2241211)
1990
35
The eosinophilia-myalgia syndrome. (2339858)
1990
36
Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States, as of January 9, 1990. (2104651)
1990
37
From the Centers for Disease Control. Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States, as of January 9, 1990. (2296113)
1990
38
Tryptophan and eosinophilia myalgia syndrome. (2244397)
1990
39
The eosinophilia-myalgia syndrome. (2219901)
1990
40
PMS and eosinophilia-myalgia syndrome. (2313027)
1990
41
L-tryptophan associated eosinophilia-myalgia syndrome. (2273504)
1990
42
Eosinophilia-myalgia syndrome in Wisconsin. (2293489)
1990
43
Eosinophilia-myalgia syndrome associated with exposure to tryptophan from a single manufacturer. (2355442)
1990
44
Eosinophilia myalgia syndrome associated with tryptophan. (2400862)
1990
45
Eosinophilia myalgia syndrome: case report. (2332620)
1990
46
An eosinophilia-myalgia syndrome associated with an L-tryptophan containing product. (2273501)
1990
47
Update: analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome. (2122210)
1990
48
Eosinophilia-myalgia syndrome--old questions for a new syndrome. (2273483)
1990
49
Treatment of eosinophilia-myalgia syndrome. (2370894)
1990
50
Eosinophilia-myalgia syndrome and L-tryptophan-containing products--New Mexico, Minnesota, Oregon, and New York, 1989. (2509891)
1989

Genetic Variations for Eosinophilia-Myalgia Syndrome

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Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilia-Myalgia Syndrome

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Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

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37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 51QIAGEN, 29KEGG
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Compounds for genes affiliated with Eosinophilia-Myalgia Syndrome

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44Novoseek, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1indoleamine4410.6TDO2
2pge24410.5TGFB1
3gm-csf44 2811.5IFNG
4hydrocortisone44 2 59 1113.4CRH
5tranilast4410.4IFNG
6n-formylkynurenine4410.3TDO2, IDO1
7glutamate4410.3AHR
8toluene diisocyanate4410.2IL5, HNMT
91-methyltryptophan4410.2IFNG, IDO1
103-hydroxyanthranilic acid44 2411.1IDO1, IFNG
11kynurenine449.9TDO2, IFNG, IDO1
12poly(i-c)449.9IDO1, IFNG, IL5
135-hydroxytryptamine449.8IDO1, CRH, TDO2
14l-nmma449.8IDO1, IFNG, CRH
15il 10449.8TGFB1, IL5, IFNG
16sodium nitroprusside449.8TGFB1, IL5, CRH
17rantes449.8TGFB1, IFNG, IDO1
18il-12449.7IFNG, IL5
19serine449.7TGFB1, TDO2, TYRP1
20dpa 1449.7HLA-DQA1, HLA-DRB1
21gold sodium thiomalate449.7HLA-DRB1, IFNG
22l-tryptophan44 28 11 2412.7TDO2, IL5, IFNG, IDO1
23glatiramer acetate44 1110.6IFNG, HLA-DRB1, IL5
24herbimycin a44 5910.6IL5, AHR, IFNG
25aspartate449.5CRH, AHR, TDO2
26allergens449.5IL5, HLA-DRB1, IFNG
27carbon449.5TDO2, AHR, CRH
28indomethacin44 59 28 1112.5IFNG, CRH, IL5, TGFB1
29thyroxine44 2410.5CRH, AHR, IL5, TGFB1
30tacrolimus44 49 1111.4TGFB1, IL5, IFNG
31vitamin d449.4CRH, AHR, IL5, TGFB1
32methylcellulose449.4IFNG, AHR, IL5, TGFB1
33lapatinib44 49 1111.3HLA-DQA1, HLA-DRB1
34thymidine44 2410.3IDO1, IFNG, IL5, TGFB1
35histamine44 28 2411.2HNMT, IFNG, CRH, IL5, TGFB1
36sb 20358044 5910.1TGFB1, IL5, AHR, CRH, IFNG
37cysteine448.8IL5, AHR, TYRP1, CRH, IFNG
38adenylate448.8IL5, AHR, TYRP1, CRH
39dexamethasone44 49 28 1111.8IDO1, IFNG, CRH, AHR, IL5, TGFB1
40alanine448.7HLA-DRB1, CRH, AHR, TDO2, TGFB1
41oligonucleotide448.7TGFB1, TYRP1, HLA-DQA1, HLA-DRB1, IDO1
42arginine447.8TDO2, IDO1, IFNG, HLA-DRB1, HLA-DQA1, CRH

GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

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16Gene Ontology
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Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.3HLA-DQA1, HLA-DRB1
2clathrin-coated endocytic vesicle membraneGO:0306698.7TYRP1, HLA-DQA1, HLA-DRB1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1tryptophan catabolic process to kynurenineGO:01944110.1TDO2, IDO1
2tryptophan catabolic processGO:00656910.1TDO2, IDO1
3cellular response to dexamethasone stimulusGO:07154910.0CRH, TGFB1
4female pregnancyGO:0075659.7TGFB1, CRH, IDO1
5extrinsic apoptotic signaling pathwayGO:0971919.7TGFB1, IFNG
6positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.6CRH, HLA-DRB1
7protein import into nucleus, translocationGO:0000609.6TGFB1, IFNG
8regulation of cartilage developmentGO:0610359.5TGFB1, SCXA
9positive regulation of interleukin-12 productionGO:0327359.5IFNG, IDO1
10positive regulation of collagen biosynthetic processGO:0329679.3SCXA, TGFB1
11interferon-gamma-mediated signaling pathwayGO:0603339.2IFNG, HLA-DRB1, HLA-DQA1
12positive regulation of gene expressionGO:0106289.0TGFB1, CRH, SCXA
13cytokine-mediated signaling pathwayGO:0192218.9IL5, HLA-DQA1, HLA-DRB1, IFNG

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:0323959.0HLA-DQA1, HLA-DRB1
2protein heterodimerization activityGO:0469828.5TGFB1, AHR, TYRP1, SCXA

Products for genes affiliated with Eosinophilia-Myalgia Syndrome

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Sources for Eosinophilia-Myalgia Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet