MCID: ESN002
MIFTS: 38

Eosinophilia-Myalgia Syndrome malady

Rare diseases, Blood diseases categories

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

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Aliases & Descriptions for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 10 45 47 12 65 36
Ems 45 2
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 45
 
Severe Muscle Pain and Abnormally High Eosinophils 45
Eosinophilia Myalgia Syndrome 10
L-Tryptophan Induced Ems 45


Classifications:



External Ids:

Disease Ontology10 DOID:998
ICD9CM29 710.5
SNOMED-CT59 95416007
MeSH36 D016603

Summaries for Eosinophilia-Myalgia Syndrome

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CDC:2 Emergency medical services (EMS) workers are primary providers of pre-hospital emergency medical care and integral components of disaster response. The potentially hazardous job duties of EMS workers include lifting patients and equipment, treating patients with infectious illnesses, handling hazardous chemical and body substances, and participating in the emergency transport of patients in ground and air vehicles. These duties create an inherent risk for EMS worker occupational injuries and illnesses; and research has shown that they have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary: Eosinophilia-Myalgia Syndrome, also known as ems, is related to scleroderma and eosinophilia. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Inflammatory Response Pathway. Affiliated tissues include skin, heart and lung, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia:68 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

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Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to eosinophilia-myalgia syndrome

Symptoms for Eosinophilia-Myalgia Syndrome

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Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

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Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
15-hydroxytryptophan10
2TryptophanNutraceutical51

Interventional clinical trials:

idNameStatusNCT IDPhase
1L-5-HTP-Related EMSCompletedNCT00001918
2Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical TrialsCompletedNCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome


Cochrane evidence based reviews: Eosinophilia-Myalgia Syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

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Anatomical Context for Eosinophilia-Myalgia Syndrome

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MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

33
Skin, Heart, Lung, Brain, T cells, Neutrophil, Liver

Animal Models for Eosinophilia-Myalgia Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Eosinophilia-Myalgia Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4CRH, IFNG, IL5, TGFB1
2MP:00053977.3CRH, HLA-DQA1, IDO1, IFNG, IL5, TGFB1
3MP:00053877.0CRH, HLA-DQA1, IDO1, IFNG, IL5, TGFB1

Publications for Eosinophilia-Myalgia Syndrome

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Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? (19941898)
2010
2
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. (17806156)
2007
3
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. (17892268)
2007
4
Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. (10606395)
1999
5
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome. (9817085)
1998
6
Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. (9076948)
1997
7
The eosinophilia-myalgia syndrome and the toxic oil syndrome. Pursuing parallels. (8906286)
1996
8
1995 Bailey K. Ashford lecture. Public health lessons from two catastrophic epidemics: the toxic oil syndrome and the eosinophilia-myalgia syndrome. (8744866)
1996
9
1,1'-Ethylidenebis[L-tryptophan], an impurity in L-tryptophan associated with eosinophilia-myalgia syndrome, stimulates type I collagen gene expression in human fibroblasts in vitro. (8624499)
1995
10
Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. (8579979)
1995
11
Eosinophilia-myalgia syndrome: a long-term follow-up study. (7660215)
1995
12
P-31 magnetic resonance spectroscopy of skeletal muscle in the eosinophilia-myalgia syndrome: a preliminary study. (8035389)
1994
13
Pharmacogenetic characteristics of the eosinophilia-myalgia syndrome. (7955801)
1994
14
The eosinophilia-myalgia syndrome: lessons from Germany. (8015338)
1994
15
Studies with 1,1'-ethylidenebis(tryptophan), a contaminant associated with L-tryptophan implicated in the eosinophilia-myalgia syndrome. (8184420)
1994
16
Eosinophilia myalgia syndrome: absence of immunoglobulin reactivity suggests a cellular rather than humoral mechanism. (7976226)
1994
17
Eosinophilia-myalgia syndrome in Germany: an epidemiologic review. (8015323)
1994
18
Production of polyclonal antibodies against 1,1'-ethyliden bis[L-tryptophan] (EBT), a potential contaminant causing eosinophilia-myalgia syndrome (EMS). (8475503)
1993
19
Eosinophilia-myalgia syndrome and fasciitis with an active alveolitis. (8355447)
1993
20
Toxic oil syndrome and eosinophilia-myalgia syndrome: May 8-10, 1991, World Health Organization meeting report. (8266108)
1993
21
The eosinophilia-myalgia syndrome: current concepts and future directions. (1551286)
1992
22
Eosinophilia-myalgia syndrome. Natural history in a population-based cohort. (1520057)
1992
23
Eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1386918)
1992
24
Central nervous system involvement in the eosinophilia-myalgia syndrome. (1417516)
1992
25
A histopathologic comparison of Shulman's syndrome (diffuse fasciitis with eosinophilia) and the fasciitis associated with the eosinophilia-myalgia syndrome. (1732344)
1992
26
Identification of decomposition products of 1,1'-ethylidenebis [L-tryptophan], a compound associated with eosinophilia-myalgia syndrome. (1504513)
1992
27
Episodic angioedema with eosinophilia versus eosinophilia-myalgia syndrome. (1583248)
1992
28
Chronic demyelinating polyneuropathy associated with eosinophilia-myalgia syndrome. (1534836)
1992
29
Eosinophilia-myalgia syndrome: the aftermath. (1523446)
1992
30
Endogenous formation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid in man as the possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. (1929872)
1991
31
Environmental pathology. Mast cell and eosinophil infiltration in intestinal mucosa of Lewis rats treated with L-tryptophan implicated in human eosinophilia myalgia syndrome. (2068062)
1991
32
Eosinophilia-myalgia syndrome: the Cleveland Clinic experience. (1934454)
1991
33
Eosinophilia-myalgia syndrome associated with L-tryptophan use. (1984598)
1991
34
L-tryptophan-induced eosinophilia-myalgia syndrome. (1829754)
1991
35
Postmortem studies of the heart in three fatal cases of the eosinophilia-myalgia syndrome. (2058857)
1991
36
Unraveling the eosinophilia-myalgia syndrome. (1863082)
1991
37
Eosinophilia-myalgia syndrome. A clinical case series of 21 patients. New Mexico Eosinophilia-Myalgia Syndrome Study Group. (2001136)
1991
38
Cutaneous manifestations of the L-tryptophan-associated eosinophilia-myalgia syndrome: a spectrum of sclerodermatous skin disease. (2273104)
1990
39
Dermal mucinosis in the eosinophilia-myalgia syndrome. (2241211)
1990
40
The eosinophilia-myalgia syndrome. (2339858)
1990
41
Clinical spectrum of the systemic manifestations of the eosinophilia-myalgia syndrome. (2164712)
1990
42
Eosinophilia-myalgia syndrome: unresolved questions. (2372919)
1990
43
Peripheral neuropathy in the eosinophilia-myalgia syndrome associated with L-tryptophan ingestion. (2162498)
1990
44
L-tryptophan induced eosinophilia-myalgia syndrome. (2273498)
1990
45
Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome. (2166897)
1990
46
Eosinophilia-myalgia syndrome. Results of national surveillance. (2398610)
1990
47
The eosinophilia-myalgia syndrome with neuritis associated with L-tryptophan use. (2339856)
1990
48
Update: eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan--United States, as of January 9, 1990. (2104651)
1990
49
Eosinophilia-myalgia syndrome with myoclonic jerks. (2292676)
1990
50
Eosinophilia-myalgia syndrome--New Mexico. (2509886)
1989

Variations for Eosinophilia-Myalgia Syndrome

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Expression for genes affiliated with Eosinophilia-Myalgia Syndrome

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Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for genes affiliated with Eosinophilia-Myalgia Syndrome

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Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL5, TGFB1
29.5IFNG, IL5
39.5IFNG, IL5
4
Show member pathways
9.4IFNG, TGFB1
59.4IFNG, TGFB1
69.4IFNG, TGFB1
79.4IFNG, TGFB1
89.4IFNG, TGFB1
9
B cell receptor signaling pathway (KEGG)
Show member pathways
9.1IFNG, TGFB1
109.1IFNG, IL5, TGFB1
119.0IDO1, IFNG
129.0HLA-DQA1, IFNG, TGFB1
139.0HLA-DQA1, IFNG, TGFB1
14
Show member pathways
9.0HLA-DQA1, IFNG, TGFB1
15
Show member pathways
8.6HLA-DQA1, IFNG, IL5, TGFB1

GO Terms for genes affiliated with Eosinophilia-Myalgia Syndrome

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Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-17 productionGO:003270010.1IFNG, TGFB1
2protein import into nucleus, translocationGO:000006010.1IFNG, TGFB1
3extrinsic apoptotic signaling pathwayGO:009719110.1IFNG, TGFB1
4interferon-gamma-mediated signaling pathwayGO:006033310.0HLA-DQA1, IFNG
5antigen processing and presentationGO:00198829.9HLA-DQA1, IFNG
6response to immobilization stressGO:00359029.9CRH, HNMT
7negative regulation of T cell proliferationGO:00421309.8IDO1, TGFB1
8positive regulation of interleukin-12 productionGO:00327359.6IDO1, IFNG
9cellular response to dexamethasone stimulusGO:00715499.5CRH, TGFB1
10response to cocaineGO:00422209.3CRH, HNMT
11immune responseGO:00069559.3HLA-DQA1, IFNG, IL5
12negative regulation of gene expressionGO:00106299.3CRH, IFNG, TGFB1
13cytokine-mediated signaling pathwayGO:00192219.1HLA-DQA1, IFNG, IL5
14female pregnancyGO:00075659.0CRH, IDO1, TGFB1
15positive regulation of gene expressionGO:00106288.9CRH, IFNG, TGFB1
16positive regulation of cell proliferationGO:00082848.8CRH, IFNG, IL5, TGFB1
17inflammatory responseGO:00069548.7CRH, IDO1, IL5, TGFB1
18response to drugGO:00424938.6CRH, IFNG, TGFB1

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.1IFNG, IL5, TGFB1

Sources for Eosinophilia-Myalgia Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet