EOE
MCID: ESN001
MIFTS: 56

Eosinophilic Esophagitis (EOE) malady

Gastrointestinal diseases, Rare diseases categories

Summaries for Eosinophilic Esophagitis

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OMIM:46 Eosinophilic esophagitis (EOE) has an incidence of approximately 1 per 10,000 people. Symptoms include difficulty... (610247) more...

MalaCards based summary: Eosinophilic Esophagitis, also known as EOE, is related to esophagitis and eosinophilic gastroenteritis, and has symptoms including failure to thrive, vomiting and dysphagia. An important gene associated with Eosinophilic Esophagitis is CCL26 (chemokine (C-C motif) ligand 26), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and TSLP Signaling Pathway. The compounds omalizumab and ovomucoid have been mentioned in the context of this disorder. Affiliated tissues include esophagus, testes and t cells, and related mouse phenotype respiratory system.

Disease Ontology:9 An esophagitis characterized by inflammation involiving eosinophils located in esophagus.

Wikipedia:64 Eosinophilic esophagitis (eosinophilic oesophagitis), also known as allergic oesophagitis, is an... more...

Description from OMIM:46 613412

Aliases & Classifications for Eosinophilic Esophagitis

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Sources:
9Disease Ontology, 11DISEASES, 48Orphanet, 46OMIM, 61UMLS, 28ICD9CM, 34MeSH, 39NCIt, 56SNOMED-CT, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Eosinophilic Esophagitis, Aliases & Descriptions:

Name: Eosinophilic Esophagitis 9 11 48 46 61
 
Eoe 48 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
eosinophilic esophagitis:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology9 DOID:13922
ICD9CM28 530.13
MeSH34 D057765
NCIt39 C27105
SNOMED-CT56 235599003
MESH via Orphanet35 D057765
ICD10 via Orphanet27 K20
UMLS via Orphanet62 C0341106

Related Diseases for Eosinophilic Esophagitis

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Diseases in the Eosinophilic Esophagitis family:

Esophagitis, Eosinophilic, 2 Esophagitis, Eosinophilic, 1

Diseases related to Eosinophilic Esophagitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis31.8IL13, IL5, CCL11, CCL26
2eosinophilic gastroenteritis30.7IL5, CCL11
3food allergy30.7CCL11, IL13, IL5
4eosinophilia30.4CCL11, CCL26, IL13, IL5
5asthma30.3IL13, IL5
6hypereosinophilic syndrome30.2IL5, CCL11
7gastroesophageal reflux disease10.6
8dysphagia10.5
9celiac disease10.5
10barrett's esophagus10.4
11gastroenteritis10.4
12churg-strauss syndrome10.4IL5
13strongyloidiasis10.4IL5
14folliculitis10.3CCL11
15esophageal atresia10.3
16extraskeletal ewing sarcoma10.2
17esophageal candidiasis10.2
18candidiasis10.2
19herpes simplex10.2
20eosinophilic enteropathy10.2
21gamma chain deficiency10.2IL13, TSLP
22helminthiasis10.2IL13, IL5
23filariasis10.2IL13, IL5
24cutaneous leishmaniasis10.2IL5, IL13
25chronic eosinophilic pneumonia10.1CCL11, IL5
26giant papillary conjunctivitis10.1CCL11, IL5
27mastocytosis10.1IL13, IL5
28leishmaniasis10.1IL13, IL5
29sinusitis10.1CCL11, IL5
30bronchitis10.1IL5, CCL11
31schistosomiasis10.1IL5, IL13
32arthritis10.0
33crohn's disease10.0
34cystic fibrosis10.0
35rheumatoid arthritis10.0
36pharyngitis10.0
37granular cell tumor10.0
38rubinstein-taybi syndrome10.0
39diffuse idiopathic skeletal hyperostosis10.0
40inflammatory myofibroblastic tumor10.0
41achalasia10.0
42juvenile polyposis syndrome10.0
43duodenitis10.0
44colitis10.0
45esophageal disease10.0
46gastritis10.0
47hyperostosis10.0
48laryngitis10.0
49pulmonary embolism10.0
50laryngeal papillomatosis10.0

Graphical network of the top 20 diseases related to Eosinophilic Esophagitis:



Diseases related to eosinophilic esophagitis

Symptoms for Eosinophilic Esophagitis

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Symptoms by clinical synopsis from OMIM:

610247

Clinical features from OMIM:

610247,613412

HPO human phenotypes related to Eosinophilic Esophagitis:

id Description Frequency HPO Source Accession
1 failure to thrive HP:0001508
2 vomiting HP:0002013
3 dysphagia HP:0002015

Drugs & Therapeutics for Eosinophilic Esophagitis

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Drug clinical trials:

Search ClinicalTrials for Eosinophilic Esophagitis

Search NIH Clinical Center for Eosinophilic Esophagitis

Genetic Tests for Eosinophilic Esophagitis

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Anatomical Context for Eosinophilic Esophagitis

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MalaCards organs/tissues related to Eosinophilic Esophagitis:

32
Testes, T cells, Skin, Lymph node, Smooth muscle

FMA organs/tissues related to Eosinophilic Esophagitis:

15
Esophagus

Animal Models for Eosinophilic Esophagitis or affiliated genes

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MGI Mouse Phenotypes related to Eosinophilic Esophagitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4IL13, IL5, CCL11, TSLP

Publications for Eosinophilic Esophagitis

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Articles related to Eosinophilic Esophagitis:

(show top 50)    (show all 534)
idTitleAuthorsYear
1
Comparison of atopic features between children and adults with eosinophilic esophagitis. (25295809)
2014
2
Are major basic protein, eotaxin-3 and leukotriene enzyme staining useful for diagnosing eosinophilic esophagitis? (Am j gastroenterol 2012;107:1503-1511). (23350059)
2013
3
Practical management of eosinophilic esophagitis. (23805960)
2013
4
Causes, evaluation, and consequences of eosinophilic esophagitis. (24117638)
2013
5
Molecular diagnosis of eosinophilic esophagitis by gene expression profiling. (23978633)
2013
6
a8^a8^mTechnetium-labeled heparin: a new approach to detection of eosinophilic esophagitis-associated inflammation. (23895898)
2013
7
Eosinophilic esophagitis: is it also a surgical disease? (23414856)
2013
8
The pathogenesis of eosinophilic esophagitis: beyond the eosinophil. (23625288)
2013
9
Serum Eosinophil Cationic Protein is Superior to Mast Cell Tryptase as Marker for Response to Topical Corticosteroid Therapy in Eosinophilic Esophagitis. (24177377)
2013
10
Frequent sensitization to Candida albicans and profilins in adult eosinophilic esophagitis. (23735202)
2013
11
Immunoreactivity of p53 and Ki-67 for dysplastic changes in children with eosinophilic esophagitis. (23718721)
2013
12
Clinical analysis of primary eosinophilic esophagitis. (23667751)
2013
13
A case of eosinophilic esophagitis discovered with positron emission tomography imaging: a case report. (23855975)
2013
14
T cell co-stimulatory molecules: a co-conspirator in the pathogenesis of eosinophilic esophagitis? (23456499)
2013
15
Dietary therapies for eosinophilic esophagitis. (24236700)
2013
16
Diagnosis and management of eosinophilic esophagitis. (22728382)
2012
17
Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitis. (22134787)
2012
18
Eosinophilic esophagitis: a clinical, endoscopic, and histopathologic review. (23025974)
2012
19
Esophageal functional impairments in experimental eosinophilic esophagitis. (22361731)
2012
20
The otolaryngologic manifestations in children with eosinophilic esophagitis. (22093742)
2012
21
Selective elimination diet based on skin testing has suboptimal efficacy for adult eosinophilic esophagitis. (22867695)
2012
22
Fluoroscopic findings in pediatric eosinophilic esophagitis. (22241596)
2012
23
Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. (21570716)
2011
24
Fluticasone and food allergen elimination reverse sub-epithelial fibrosis in children with eosinophilic esophagitis. (20458625)
2011
25
Boerhaave's syndrome as the primary manifestation of adult eosinophilic esophagitis. Two case reports and a review of the literature. (21309916)
2011
26
Medication-induced esophageal tattoo in a patient with eosinophilic esophagitis. (20619833)
2011
27
The natural history and complications of eosinophilic esophagitis. (22040638)
2011
28
Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methods. (22099448)
2011
29
Variable reliability of endoscopic findings with white-light and narrow-band imaging for patients with suspected eosinophilic esophagitis. (21377547)
2011
30
Severe dysphagia in children with eosinophilic esophagitis and esophageal stricture: an indication for balloon dilation? (19934772)
2010
31
Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. (20371398)
2010
32
Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? (20524860)
2010
33
Defining the role of food allergy in a population of adult patients with eosinophilic esophagitis. (20887270)
2010
34
Acid-suppressive therapy and eosinophilic esophagitis: friends or foes? (20203650)
2010
35
Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis. (20815913)
2010
36
Eosinophilic esophagitis: clinical features, endoscopic findings and response to treatment. (21152459)
2010
37
Image of the month. Gone fishin': a surprising finding while investigating possible eosinophilic esophagitis. (20683199)
2010
38
A case-control study of sociodemographic and geographic characteristics of 335 children with eosinophilic esophagitis. (19118642)
2009
39
Eosinophilic esophagitis: the newest esophageal inflammatory disease. (19404267)
2009
40
Vitamin D deficiency, eosinophilic esophagitis, and health literacy. (19797953)
2009
41
Eosinophilic esophagitis. (19115464)
2009
42
Clinical evaluation of the adult who has eosinophilic esophagitis. (19141337)
2009
43
Pharmacologic treatment of eosinophilic esophagitis. (18061110)
2008
44
Eosinophilic esophagitis and intermediate esophagitis after tracheoesophageal fistula repair: a case series. (18485944)
2008
45
Eosinophilic esophagitis : a cause of dysphagia]. (18214405)
2008
46
Demographic data and symptoms of eosinophilic esophagitis in adults. (18061099)
2008
47
Eosinophilic esophagitis--pathogenesis, clinical presentation and therapeutic management]. (18080228)
2007
48
Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. (17919504)
2007
49
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. (16453027)
2006
50
Eosinophilic esophagitis. (16606552)
2006

Variations for Eosinophilic Esophagitis

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Expression for genes affiliated with Eosinophilic Esophagitis

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Expression patterns in normal tissues for genes affiliated with Eosinophilic Esophagitis

Search GEO for disease gene expression data for Eosinophilic Esophagitis.

Pathways for genes affiliated with Eosinophilic Esophagitis

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Pathways related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CCL11, CCL26
29.4TSLP, CCL11
39.4IL13, IL5
49.4IL13, IL5
5
Show member pathways
9.4IL13, IL5
69.4IL13, IL5
79.4IL13, IL5
89.4IL5, IL13
99.3IL5, CCL11
10
Show member pathways
Type III interferon signaling37
9.0TSLP, IL5, IL13
119.0CCL26, CCL11, IL5
12
Show member pathways
8.8CCL11, IL5, IL13
13
Show member pathways
8.7CLDN1, CCL26, CCL11
14
Show member pathways
8.4CCL26, CCL11, IL5, IL13
15
Show member pathways
8.4CCL26, CCL11, IL5, IL13
16
Show member pathways
8.4CCL26, CCL11, IL5, IL13
17
Show member pathways
8.4CCL26, CCL11, IL5, IL13
18
Show member pathways
8.0IL13, IL5, CCL11, CCL26, TSLP

Compounds for genes affiliated with Eosinophilic Esophagitis

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Compounds related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1omalizumab44 1210.9IL13, IL5
2ovomucoid449.8IL13, IL5
34-ipp609.8IL13, IL5
4git 27609.8IL5, IL13
5glatiramer acetate44 1210.8IL13, IL5
6praziquantel44 1210.8IL13, IL5
7pirfenidone44 6010.8IL5, IL13
8unicap449.7IL5, CCL11
9penicillin449.7IL13, IL5
10amphotericin b449.7IL5, IL13
11sodium cromoglycate449.7CCL11, IL5
12lte4449.7CCL11, IL5
13as 10144 6010.7IL5, IL13
145-oxoete449.7CCL11, IL5
15roxithromycin44 29 1211.7CCL11, IL5
16cetirizine44 29 25 1212.7CCL11, IL5
17ltd4449.7IL13, IL5
18il-12449.7IL5, IL13
19pranlukast44 29 1211.7CCL11, IL5
20ketotifen44 1210.7CCL11, IL5
21clarithromycin44 1210.6CCL11, IL5
22gm-csf44 2910.5IL5, IL13
23groalpha449.5CCL11, IL13
24nickel44 2510.4IL5, IL13
25ccl344 2910.4IL13, CCL11, CCL26
26salmeterol44 50 29 1212.3CCL11, IL5, IL13
27montelukast44 50 29 1212.3IL13, IL5, CCL11
28ltc4449.3CCL11, IL13, IL5
29budesonide44 50 1211.3IL5, CCL11, IL13
30salbutamol44 50 29 25 1213.2IL5, IL13, CCL11
31fluticasone propionate44 50 60 1212.2IL13, IL5, CCL11
32rolipram44 60 2911.2IL13, IL5, CCL11
33pgd2449.2CCL11, IL5, IL13
34methacholine44 50 1211.2CCL11, IL5, IL13
35leukotriene b444 60 2511.2IL5, IL13, CCL11
36prednisolone44 29 1211.2CCL11, IL5, IL13
37ionomycin449.2IL5, IL13, CCL11
38fmlp449.2IL13, IL5, CCL11
39tacrolimus44 50 1211.2IL13, IL5, CCL11
40indomethacin44 29 60 1212.0IL5, IL13, CCL11
41poly(i-c)449.0IL5, CCL11
42sb 20358044 6010.0IL5, CCL11, IL13
43histamine44 29 2511.0CCL11, IL13, IL5
44ly294002448.9IL13, IL5, CCL11
45rantes448.9IL5, CCL26, IL13, CCL11
46allergens448.9TSLP, CCL11, IL5, IL13
47pge2448.8CCL11, IL13, IL5
48cyclosporin a44 29 6010.7IL13, CCL11, IL5
49retinoic acid44 259.6CCL11, IL5, SPRR3, IL13
50tarc448.5TSLP, IL13, IL5, CCL11, CCL26

GO Terms for genes affiliated with Eosinophilic Esophagitis

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Cellular components related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.0IL13, IL5, CCL11, CCL26, TSLP

Biological processes related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac GTPase activityGO:0328559.6CCL11, CCL26
2positive regulation of B cell proliferationGO:0308909.5IL5, IL13
3positive regulation of actin filament polymerizationGO:0308389.5CCL11, CCL26
4positive regulation of cell migrationGO:0303359.5CCL11, CCL26
5positive regulation of endothelial cell proliferationGO:0019389.4CCL11, CCL26
6chemotaxisGO:0069359.2CCL11, CCL26
7inflammatory responseGO:0069548.6IL13, IL5, CCL11, CCL26
8immune responseGO:0069558.6CCL26, CCL11, IL5, IL13

Molecular functions related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.5CCL11, CCL26
2cytokine activityGO:0051258.7IL13, IL5, TSLP

Products for genes affiliated with Eosinophilic Esophagitis

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Sources for Eosinophilic Esophagitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet