Eosinophilic Esophagitis malady

Wikipedia: Eosinophilic esophagitis (eosinophilic oesophagitis) is an allergic inflammatory condition of the...⁴⁴ more...

MalaCards: Eosinophilic Esophagitis, also known as eosinophilic esophagitis (disorder), is related to gastroesophageal reflux disease and celiac disease. An important gene associated with Eosinophilic Esophagitis is CCL26 (chemokine (C-C motif) ligand 26), and among its related pathways are Graft-versus-host disease and OX40 Pathway. The compounds endotoxin and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotypes are respiratory system and immune system.

Aliases & Descriptions:

eosinophilic esophagitis 6 8 43 eosinophilic esophagitis (disorder) 6

Disease types for eosinophilic esophagitis family:

esophagitis, eosinophilic, 2	esophagitis, eosinophilic, 1

Diseases related to eosinophilic esophagitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 404)

id	Related Disease	Score	Top Affiliating Genes
1	gastroesophageal reflux disease	30.6	IL5, CCL26, CCL11, CCR3
2	celiac disease	29.7	HLA-DQA1, HLA-DQB1, HLA-DRB1
3	esophagitis	25.2	VCAM1, MUC5AC, IVL, MKI67, FLG, IL10
4	fibrosis	21.6	VCAM1, MUC5AC, IL10, IL13, IL5, CCL11
5	familial eosinophilia	13.6	IL5, PRG2
6	granulomatous angiitis	13.6	IL5, IGES
7	papillary conjunctivitis	13.6	CCL11, CCL24, PRG2
8	intestinal schistosomiasis	13.5	IL13, IL5
9	dermatographia	13.4	IGHE, PRG2
10	ichthyosis vulgaris	13.4	IVL, FLG, SPRR3
11	angiostrongyliasis	13.4	IL13, IL5, CCL24
12	chronic eosinophilic pneumonia	13.4	IL5, CCL11, RNASE3
13	giant papillary conjunctivitis	13.4	IL5, CCL11, RNASE3
14	hyper-ige syndrome	13.4	IGES, IGHE
15	egg allergy	13.4	IL5, IGHE
16	exanthem	13.3	IL5, CCL11
17	common cold	13.3	IL5, CCL11, RNASE3
18	allergic bronchopulmonary aspergillosis	13.3	IL5, IGES, IGHE
19	corneal ulcer	13.3	MUC5AC, CCL11, CCR3, PRG2
20	pthirus pubis infestation	13.2	IL5, CCL11, IGHE
21	gamma chain deficiency	13.2	IL13, TSLP, STAT6
22	diffuse panbronchiolitis	13.2	MUC5AC, IL13, IL5
23	panbronchiolitis	13.2	MUC5AC, IL13, IL5
24	eczema herpeticum	13.2	FLG, IGHE, TSLP
25	contact dermatitis	13.2	FLG, IL5, IGHE
26	eosinophilic meningitis	13.2	IL10, IL5, CCL24
27	anisakiasis	13.1	IGHE, RNASE3
28	pemphigoid gestationis	13.1	CCL11, HLA-DRB1
29	membranoproliferative glomerulonephritis type 2	13.1	VCAM1, IGES, TSLP
30	lipoid nephrosis	13.1	IL10, IL13
31	status asthmaticus	13.1	MUC5AC, IL5, CCL11, RNASE3
32	bowen syndrome	13.1	IVL, MKI67, FLG
33	lacrimal duct obstruction	13.1	MUC5AC, CCL11, IGES, RNASE3
34	toxocariasis	13.0	IGHE, RNASE3
35	mucoepidermoid carcinoma	13.0	MUC5AC, IVL, MKI67
36	paragonimiasis	13.0	IL5, IGHE, RNASE3, RNASE2
37	intrinsic asthma	13.0	IL5, IGES, IGHE, RNASE3
38	smooth muscle tumor	13.0	IVL, MKI67, CCL11
39	ascariasis	13.0	IL5, IGHE, RNASE3, RNASE2
40	multiple sclerosis	13.0	HLA-DQB1, HLA-DRB1
41	keratoacanthoma	12.9	IVL, MKI67, FLG
42	helminthiasis	12.9	IL13, IL5, IGHE, RNASE3
43	middle ear cholesteatoma	12.9	IVL, MKI67, FLG
44	cholecystitis	12.9	MUC5AC, MKI67, IL5
45	retinopathy of prematurity	12.8	IL10, IL13, IL5, CCL11
46	paranasal sinus disease	12.8	IL5, IFNG
47	chronic obstructive pulmonary disease	12.8	MUC5AC, IL13, CCL11, CCR3, RNASE3
48	cystic fibrosis lung disease	12.8	MUC5AC, IL10, RNASE3
49	pulmonary alveolar proteinosis	12.8	IL10, IL5, IGHE
50	bronchitis	12.8	IL5, CCL11, CCR3, IGHE, RNASE3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to eosinophilic esophagitis:

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MGI Mouse Phenotypes related to eosinophilic esophagitis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.9	CCL24, STAT6, PRG2
2	immune system phenotype	MP:0005387	7.9	TSLP, HLA-DQB1, HLA-DQA1, IFNG, FLG, MUC5AC
3	hematopoietic system phenotype	MP:0005397	4.9	VCAM1, PRG2, STAT6, TSLP, HLA-DQB1, HLA-DQA1

Articles related to eosinophilic esophagitis:

(show all 28)

id	Title	Authors	Year	Affiliating Genes
1	Coordinate interaction between IL-13 and epithelial d ifferentiation cluster genes in eosinophilic esophagitis. (20208004)	Blanchard C.... Rothenberg M.E.	2010	IL13, FLG, CCL26
2	Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. (19796194)	Aceves S.S.... Broide D.H.	2010	VCAM1
3	Adult Patients with Eosinophilic Esophagitis Do Not S how an Increased Frequency of the HLA-DQ2/DQ8 Genotypes Predisposing to Celiac Disease. (20725783)	Lucendo A.J.... Rodrigo L.	2010	HLA-DQA1, HLA-DQB1, HLA-DRB1
4	Eosinophilic esophagitis due to profilin allergy. (19639743)	DomA-nguez-Ortega J.... Ledesma A.	2009	RNASE3
5	Increased esophageal regulatory T cells and eosinophil characteristics in children with eosinophilic esophagitis and gastroesophageal reflux disease. (19429794)	Tantibhaedhyangkul U.... Davis C.M.	2009	CCL26
6	Is the etiology of eosinophilic esophagitis in adults a response to allergy or reflux injury? Study of cellular proliferation markers. (19207551)	Lewis C.J.... Attwood S.E.	2009	MKI67
7	Relationships between eosinophilic inflammation, tiss ue remodeling, and fibrosis in eosinophilic esophagitis. (19141355)	Aceves S.S.... Ackerman S.J.	2009	MUC5AC
8	Eosinophilic esophagitis : a cause of dysphagia (18214405)	Reichel O.... Kramer M.F.	2008	IL5
9	Eosinophilic esophagitis in children with celiac disease. (18070017)	Ooi C.Y.... Lemberg D.A.	2008	RNASE3
10	Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis. (18844613)	Lucendo A.J.... Bellon T.	2008	CCL11, IL5, CCL26
11	Eosinophilic esophagitis--pathogenesis, clinical presentation and therapeutic management (18080228)	von Arnim U.... Straumann A.	2007	IL5
12	Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis. (17592361)	Bullock J.Z.... Rothenberg M.E.	2007	CCR3, IL5RA, CCL26
13	Eosinophilic esophagitis--from a rare pediatric disease to the forefront of adult gastroenterology (18389765)	Mihai C.... Stanciu C.	2007	CCL11
14	IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. (18073124)	Blanchard C.... Rothenberg M.E.	2007	IL13, CCL26
15	Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease. (17900656)	Bhattacharya B.... Resnick M.B.	2007	CCR3, CCL11, IL5
16	Current concepts and treatment options in eosinophilic esophagitis. (17117587)	Pasha S.F.... Crowell M.D.	2006	IL13, IL5
17	Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis. (17059896)	Konikoff M.R.... Rothenberg M.E.	2006	CCL26
18	Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. (17157662)	Stein M.L.... Rothenberg M.E.	2006	IL5
19	Allergen-specific in vitro cytokine production in adult patients with eosinophilic esophagitis. (17009121)	Yamazaki K.... Kita H.	2006	IFNG, IL10, IL13
20	Cytokine expression in normal and inflamed esophageal mucosa: a study into the pathogenesis of allergic eosinophilic esophagitis. (16385249)	Gupta S.K.... HogenEsch H.	2006	IL13, IL5, CCL26
21	Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. (16453027)	Blanchard C.... Rothenberg M.E.	2006	CCL26
22	Eosinophilic esophagitis. (16606552)	AntA^n RemA-rez J.... FernA!ndez-BenA-tez M.	2006	IGHE
23	Airway manifestations of pediatric eosinophilic esophagitis: a clinical and histopathologic report of an emerging association. (16900805)	Dauer E.H.... Thompson D.M.	2006	PRG2
24	A Japanese case of eosinophilic esophagitis. (16933010)	Furuta K.... Kinoshita Y.	2006	IGES
25	Eosinophilic esophagitis. (16282772)	Noel R.J.... Rothenberg M.E.	2005	IL13, IL5
26	Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. (14724818)	Straumann A.... Simon H.U.	2003	IL5
27	Infiltrating eosinophils and eotaxin: their association with idiopathic eosinophilic esophagitis. (12392390)	Fujiwara H.... Saeki Y.	2002	CCL11
28	Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. (11742273)	Straumann A.... Simon H.U.	2001	IL5

Genes related to eosinophilic esophagitis according to GeneCards:

(show all 28)

id	Symbol	Description	Score	GeneCards Section Context
1	CCL26	chemokine (C-C motif) ligand 26	11.0	Publications
2	SPRR3	small proline-rich protein 3	11.0	Publications
3	RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	11.0
4	SIGLEC8	sialic acid binding Ig-like lectin 8	11.0
5	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
6	IGES	immunoglobulin E concentration, serum	11.0	Publications
7	CCL24	chemokine (C-C motif) ligand 24	11.0	Publications
8	TSLP	thymic stromal lymphopoietin	11.0
9	IVL	involucrin	11.0	Publications
10	IL5RA	interleukin 5 receptor, alpha	11.0	Publications
11	IL15RA	interleukin 15 receptor, alpha	11.0
12	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
13	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
14	CCR3	chemokine (C-C motif) receptor 3	11.0	Publications
15	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0	Publications
16	IL13	interleukin 13	11.0	Publications
17	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	11.0
18	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
19	ABCF1	ATP-binding cassette, sub-family F (GCN20), member 1	11.0
20	FLG	filaggrin	11.0	Publications
21	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
22	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
23	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
24	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
25	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
26	IL10	interleukin 10	11.0	Publications
27	IFNG	interferon, gamma	11.0	Publications
28	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications

Pathways related to eosinophilic esophagitis according to GeneDecks:

(show top 50)    (show all 58)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.5	HLA-DQA1
2	OX40 Pathway36	10.4	IL13, IL5
3	RAR-Gamma-RXR-Alpha Degradation36	10.3	CCL24, CCL11, CCL26
4	Regulation of eIF4 and p70S6K36	10.0	CCL24, CCL11, IL5, IL13
5	CCR3 Pathway in Eosinophils36	9.9	CCL26, CCL11, CCR3, CCL24
6	Immune response_NFAT in immune response41	9.9	IGHE
7	Immune response Antigen presentation by MHC class II10	9.8	HLA-DQA1
8	Immune response NFAT in immune response10	9.7	HLA-DQB1, HLA-DQA1
9	Immune response CCR3 signaling in eosinophils10	9.7	CCL26, CCL11, CCR3, CCL24
10	MHC class II antigen presentation38	9.4	HLA-DRB1, HLA-DQB1, HLA-DQA1
11	Akt Signaling36	9.3	CCL24, CCR3, CCL11, CCL26, IL5RA, IL10
12	NFAT Signaling and Lymphocyte Interactions36	9.3	CCL24, CCL11, CCL26, IL5, IL13, IL10
13	MIF Mediated Glucocorticoid Regulation36	9.3	CCL24, CCL11, CCL26, IL5, IL13, IL10
14	PGC1Alpha Pathway36	9.3	CCL24, CCL11, CCL26, IL5, IL13, IL10
15	MIF Regulation of Innate Immune Cells36	9.3	CCL24, CCL11, CCL26, IL5, IL13, IL10
16	all-trans-Retinoic Acid Signaling in Brain36	9.3	CCL24, CCL11, CCL26, IL5, IL13, IL10
17	PEDF Induced Signaling36	9.3	CCL24, CCL11, CCL26, IL5, IL13, IL10
18	SOCS Pathway36	9.2	CCL24, CCL11, CCL26, IL5, IL13, IL10
19	Transendothelial Migration of Leukocytes36	9.2	VCAM1, CCL26, CCL11, CCR3, CCL24, PRG2
20	IL-6 Pathway36	9.2	CCL24, CCL11, CCL26, IL5, IL13, IL10
21	IL-4 Pathway36	9.2	HLA-DQA1, HLA-DQB1, HLA-DRB1, STAT6
22	Glucocorticoid Receptor Signaling36	9.2	CCL24, CCL11, CCL26, IL5, IL13, IL10
23	Endothelin-1 Signaling Pathway36	9.2	CCL24, CCL11, CCL26, IL5, IL13, IL10
24	TGF-Beta Pathway36	9.2	CCL24, CCL11, CCL26, IL5, IL13, IL10
25	Rho Family GTPases36	9.2	PRG2, CCL24, CCL11, CCL26, IL13, IL10
26	PAK Pathway36	9.1	CCL24, CCL11, CCL26, IL5, IL13, IL10
27	Molecular Mechanisms of Cancer36	9.1	PRG2, CCL24, CCR3, CCL11, CCL26, IL5RA
28	MAPK Family Pathway36	9.0	CCL24, CCL11, CCL26, IL5, IL15RA, IL13
29	Cytokine Network36	8.9	IL10, IL13, IL5, IFNG
30	Staphylococcus aureus infection20	8.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, IL10
31	ERK Signaling36	8.8	PRG2, CCL24, CCL11, CCL26, IL5, IL13
32	Autoimmune thyroid disease20	8.8	HLA-DRB1, HLA-DQB1, HLA-DQA1, IL5, IL10
33	Type I diabetes mellitus20	8.7	HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG
34	STAT3 Pathway36	8.7	CCL24, CCR3, CCL11, CCL26, IL5RA, IL5
35	Antioxidant Action of Vitamin-C36	8.7	CCL24, CCR3, CCL11, CCL26, IL5RA, IL5
36	p38 Signaling36	8.7	CCL24, CCR3, CCL11, CCL26, IL5RA, IL5
37	Intestinal immune network for IgA production20	8.6	HLA-DRB1, HLA-DQB1, HLA-DQA1, IL5, IL15RA, IL10
38	Antigen processing and presentation20	8.6	HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG
39	Rheumatoid arthritis20	8.5	HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG
40	Tec Kinases Signaling36	8.4	STAT6, CCL24, CCR3, CCL11, CCL26, IL5RA
41	THC Differentiation Pathway36	8.2	HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG, IL10
42	JAK-STAT Pathway36	8.2	STAT6, IFNG, CCL24, CCL11, CCL26, IL5
43	Jak-STAT signaling pathway20	8.2	STAT6, TSLP, IFNG, IL5RA, IL5, IL15RA
44	Leishmaniasis20	8.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG, IL10
45	Toxoplasmosis20	8.1	HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG, IL10
46	Systemic lupus erythematosus20	8.1	IL10, IFNG, HLA-DQA1, HLA-DQB1, HLA-DRB1
47	Tuberculosis20	8.0	HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG, IL10
48	Allograft rejection20	8.0	HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG, IL5, IL10
49	Asthma20	7.9	IL10, PRG2, RNASE3, HLA-DRB1, HLA-DQB1, HLA-DQA1
50	Cytokine-cytokine receptor interaction20	7.7	TSLP, IFNG, CCL24, CCR3, CCL11, CCL26

Compounds related to eosinophilic esophagitis according to GeneDecks:

(show top 50)    (show all 121)

id	Compound	Score	Top Affiliating Genes
1	endotoxin32	10.5	CCL11
2	ionomycin32	10.0	STAT6, CCL11, IL5
3	salmeterol32 42 9 9	12.8	IL13, IL5, CCL11, RNASE3
4	ltd432	9.8	RNASE3, CCR3, IL5, IL13
5	heparin32 9 18 9	12.8	CCR3, CCL11, RNASE3, PRG2
6	mometasone furoate32	9.7	VCAM1, IL5, RNASE3
7	ltc432	9.7	RNASE3, IL13, IL5, CCL11, PRG2
8	budesonide32 42 9 9	12.7	IL5RA, CCL11, IGHE, RNASE3
9	omalizumab32 9 9	11.6	IL5, IL13, IGHE
10	unicap32	9.6	IL5, CCL11, IGHE, RNASE3
11	cetirizine32 9 18 9	12.6	IL5, IGHE, RNASE3, CCL11
12	ketotifen32 9 9	11.5	IL5, CCL11, IGHE, RNASE3
13	vegf32	9.5	RNASE3, VCAM1, MKI67, IVL
14	beclomethasone dipropionate32	9.5	IL5, VCAM1, RNASE3, IGHE
15	hematoxylin32	9.4	PRG2, MUC5AC, IVL, MKI67, FLG
16	pge232	9.3	IL13, IL5, CCL11, IVL, MUC5AC, VCAM1
17	sodium cromoglycate32	9.3	VCAM1, IL5, CCL11, IGHE, RNASE3
18	fmlp32	9.2	RNASE3, CCL11, IL5, VCAM1, PRG2, IL13
19	methacholine32 9 9	11.1	PRG2, IL13, IL5, CCL11, IGES, IGHE
20	pgd232	9.0	CCR3, IGHE, CCL11, IL5, IL13, RNASE3
21	groalpha32	9.0	CCL11, IL13, IL10, VCAM1
22	nickel32 18	10.0	FLG, HLA-DQB1, IL5, IL13
23	praziquantel32 9 9	11.0	RNASE3, IL10, IL5, IGHE, IL13
24	il-1232	8.8	IL5, IFNG, IL13, IL10
25	montelukast32 34 9 9	11.8	RNASE3, IL10, IL13, IGHE, CCL11, IL5
26	sb 20358032 42	9.8	IFNG, CCL11, STAT6, IL13, IVL, VCAM1
27	rolipram32 42	9.7	IFNG, CCL11, IL5, IL13, IL10
28	gm-csf32	8.5	IL10, IL13, IFNG, IL5
29	glatiramer acetate32 9 9	10.4	IL10, IFNG, IL5, IL13, HLA-DRB1
30	ccl332	8.4	CCL24, IL10, IL13, CCL26, CCL11, CCR3
31	salbutamol32 34 9 18 9	12.4	RNASE3, IGHE, CCL11, VCAM1, IL10, IL5
32	cysteine32	8.4	IL5, IFNG, CCR3, CCL26, MUC5AC, IVL
33	hydrocortisone32 9 9	10.2	IVL, IFNG, IGHE, IL5, IL10, IL13
34	actinomycin d32	8.2	STAT6, IFNG, IGHE, CCL24, CCR3, CCL11
35	steroid32	8.1	IGES, STAT6, IL13, MUC5AC, CCL24, RNASE3
36	arginine32	8.1	RNASE3, HLA-DQA1, IGHE, IL5RA, HLA-DRB1, IL5
37	paraffin32	8.0	IL10, VCAM1, MUC5AC, HLA-DQA1, IL5, IVL
38	fluticasone propionate32 42 9 9	11.0	VCAM1, CCL11, STAT6, IGHE, IFNG, RNASE3
39	methotrexate32 34 42 9 9	11.8	IGHE, IL5, IL10, IVL, MKI67, HLA-DRB1
40	thymidine32 18	8.7	IFNG, CCR3, IL13, CCL11, IVL, MKI67
41	prednisolone32 9 9	9.6	VCAM1, IL10, IL13, CCL11, IGHE, IFNG
42	rantes32	7.6	VCAM1, IL10, IL5, CCL26, CCL11, CCR3
43	cyclosporin a32 42	8.6	IGHE, CCL11, IFNG, IGES, RNASE3, IL5
44	tarc32	7.6	CCL11, CCL24, IGHE, IFNG, TSLP, IL10
45	nitric oxide32 9 18 9	9.9	IFNG, RNASE3, PRG2, MKI67, VCAM1, MUC5AC
46	dexamethasone32 42 34 9 9	10.5	STAT6, RNASE3, IGHE, CCR3, CCL11, IL5RA
47	histamine32 18	7.4	MUC5AC, CCL24, IGES, IGHE, IFNG, RNASE3
48	tyrosine32	6.4	HLA-DRB1, STAT6, PRG2, IVL, MUC5AC, VCAM1
49	allergens32	6.2	IVL, PRG2, STAT6, FLG, IL13, IL5
50	retinoic acid32 42 18	8.0	VCAM1, CCL11, CCR3, IGHE, SPRR3, IFNG

Cellular components related to eosinophilic esophagitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	9.4	HLA-DRB1, HLA-DQB1, HLA-DQA1
2	clathrin-coated endocytic vesicle membrane	GO:030669	9.3	HLA-DQA1, HLA-DQB1, HLA-DRB1
3	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.3	HLA-DRB1, HLA-DQB1, HLA-DQA1
4	trans-Golgi network membrane	GO:032588	9.3	HLA-DQA1, HLA-DQB1, HLA-DRB1
5	transport vesicle membrane	GO:030658	9.2	HLA-DQA1, HLA-DQB1, HLA-DRB1
6	ER to Golgi transport vesicle membrane	GO:012507	9.1	HLA-DRB1, HLA-DQB1, HLA-DQA1
7	endocytic vesicle membrane	GO:030666	8.9	HLA-DQA1, HLA-DQB1, HLA-DRB1
8	external side of plasma membrane	GO:009897	8.5	VCAM1, IL13, IFNG, HLA-DRB1
9	extracellular space	GO:005615	7.1	VCAM1, TSLP, IFNG, CCL24, CCR3, CCL11

Biological processes related to eosinophilic esophagitis according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of Rac GTPase activity	GO:032855	10.1	CCL26, CCL11, CCL24
2	eosinophil chemotaxis	GO:048245	10.1	CCL11, CCR3, CCL24
3	positive regulation of actin filament polymerization	GO:030838	10.1	CCL26, CCL11, CCL24
4	mast cell chemotaxis	GO:002551	10.0	CCL11, CCR3
5	positive regulation of endothelial cell proliferation	GO:001938	9.9	CCL24, CCR3, CCL11, CCL26
6	keratinocyte differentiation	GO:030216	9.8	IVL, FLG, SPRR3
7	chemotaxis	GO:006935	9.8	RNASE2, CCL24, CCR3, CCL11, CCL26
8	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	9.4	HLA-DRB1, HLA-DQB1
9	humoral immune response mediated by circulating immunoglobulin	GO:002455	9.2	HLA-DQB1, HLA-DRB1
10	signal transduction	GO:007165	8.9	SIGLEC8, STAT6, CCL24, CCL11, CCL26, IL5RA
11	defense response to bacterium	GO:042742	8.7	PRG2, RNASE3, IFNG, IL10
12	inflammatory response	GO:006954	8.6	ABCF1, CCL24, CCR3, CCL11, CCL26, IL5
13	interferon-gamma-mediated signaling pathway	GO:060333	8.3	HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG, VCAM1
14	cytokine-mediated signaling pathway	GO:019221	7.9	HLA-DRB1, HLA-DQB1, HLA-DQA1, IFNG, IL5, IL15RA
15	immune response	GO:006955	7.8	IL13, PRG2, HLA-DRB1, HLA-DQB1, HLA-DQA1, IGHE

Molecular functions related to eosinophilic esophagitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	9.9	CCL26, CCL11, CCL24
2	MHC class II receptor activity	GO:032395	9.1	HLA-DQA1, HLA-DQB1, HLA-DRB1
3	cytokine activity	GO:005125	8.1	TSLP, IFNG, IL5, IL13, IL10