EOE
MCID: ESN001
MIFTS: 58

Eosinophilic Esophagitis (EOE) malady

Gastrointestinal diseases category

Summaries for Eosinophilic Esophagitis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Eosinophilic esophagitis (eosinophilic oesophagitis), also known as allergic oesophagitis, is an... more...

MalaCards: Eosinophilic Esophagitis, also known as EOE, is related to esophagitis and celiac disease. An important gene associated with Eosinophilic Esophagitis is CCL26 (chemokine (C-C motif) ligand 26), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds pge2 and rantes have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin, and related mouse phenotypes are respiratory system and hematopoietic system.

Description from OMIM:46 610247,613412

Aliases & Classifications for Eosinophilic Esophagitis

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
eosinophilic esophagitis:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

eosinophilic esophagitis 8 10 48 46 60
eoe 48


External Ids:

Disease Ontology8 DOID:13922
ICD9CM27 530.13
NCIt39 C27105
MeSH34 D057765
SNOMED-CT56 235599003
MESH via Orphanet35 D057765
ICD10 via Orphanet26 K20
SNOMED-CT via Orphanet57 235599003
UMLS via Orphanet61 C0341106

Related Diseases for Eosinophilic Esophagitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Eosinophilic Esophagitis family:

Esophagitis, Eosinophilic, 2 Esophagitis, Eosinophilic, 1

Diseases related to Eosinophilic Esophagitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis32.0CCL11, CCL26, CCR3, PRG2, IL13, IL5
2celiac disease30.7HLA-DQA1
3food allergy30.7CCL11, RNASE3, IL13, IL5
4eosinophilia30.7VCAM1, CCL24, CCL11, CCL26, CCR3, STAT6
5eosinophilic gastroenteritis30.5CCL11, IL5
6gastritis30.0MUC5AC
7asthma29.9CCL11, IL13
8arthritis29.9CCR3, STAT6, FLG, IL13
9cystic fibrosis29.9HLA-DQA1, MUC5AC, RNASE3
10inflammatory bowel disease29.9CCL11, STAT6, MUC5AC, IL13, VCAM1
11rheumatoid arthritis29.9CCL11, CCR3, STAT6, FLG, PRG2, RNASE3
12esophageal disease10.8
13gastroesophageal reflux disease10.6
14barrett's esophagus10.4
15gastroenteritis10.4
16esophageal atresia10.2
17esophageal candidiasis10.1
18candidiasis10.1
19herpes simplex10.1
20eosinophilic enteropathy10.1
21extraskeletal ewing sarcoma10.0
22crohn's disease10.0
23diffuse idiopathic skeletal hyperostosis10.0
24rubinstein-taybi syndrome10.0
25achalasia10.0
26pharyngitis10.0
27granular cell tumor10.0
28eosinophilic gastritis10.0
29duodenitis10.0
30adult syndrome10.0
31juvenile polyposis syndrome10.0
32hyperostosis10.0
33intestinal disease10.0
34laryngitis10.0
35pulmonary embolism10.0
36squamous cell carcinoma10.0
37hepatitis10.0CCL11
38dermatitis herpetiformis10.0CCL11
39conjunctivitis10.0RNASE3
40paragonimiasis10.0IL5
41hepatitis b10.0HLA-DQA1
42endometriosis10.0CCL11
43severe combined immunodeficiency10.0IL5
44bronchitis10.0RNASE3
45migraine10.0RNASE2
46onchocerciasis10.0IL5, RNASE3
47churg-strauss syndrome10.0IL5, RNASE3
48pemphigus vulgaris10.0CCL11, IVL
49uveitis10.0CCL11
50urticaria10.0RNASE3, PRG2

Graphical network of the top 20 diseases related to Eosinophilic Esophagitis:



Diseases related to eosinophilic esophagitis

Clinical Features for Eosinophilic Esophagitis

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46OMIM
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Clinical features from OMIM:

610247,613412

Clinical synopsis from OMIM:

610247

Drugs & Therapeutics for Eosinophilic Esophagitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Eosinophilic Esophagitis

Drug clinical trials:

Search ClinicalTrials for Eosinophilic Esophagitis

Search NIH Clinical Center for Eosinophilic Esophagitis

Search CenterWatch for Eosinophilic Esophagitis

Genetic Tests for Eosinophilic Esophagitis

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Anatomical Context for Eosinophilic Esophagitis

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32MalaCards
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MalaCards organs/tissues related to Eosinophilic Esophagitis:

32
Testes, T cells, Skin, Lymph node, Smooth muscle, Lung

Animal Models for Eosinophilic Esophagitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eosinophilic Esophagitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.7CCL11, CCR3, STAT6, PRG2, IL13, IL5
2MP:00053978.8CCL24, CCL11, CCR3, HLA-DQA1, STAT6, FLG
3MP:00053878.7TSLP, CCL24, CCL11, CCR3, HLA-DQA1, STAT6

Publications for Eosinophilic Esophagitis

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Sources:
50PubMed
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Articles related to Eosinophilic Esophagitis:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
The pathogenesis of eosinophilic esophagitis: beyond the eosinophil. (23625288)
2013
2
A case of eosinophilic esophagitis discovered with positron emission tomography imaging: a case report. (23855975)
2013
3
Tolerance of a cow's milk-based hydrolyzed formula in patients with eosinophilic esophagitis triggered by milk. (23906026)
2013
4
Food and aeroallergen sensitization in adult eosinophilic esophagitis. (24054372)
2013
5
Diet therapy for eosinophilic esophagitis: when, why and how. (23689524)
2013
6
Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner. (23954315)
2013
7
Usefulness of oral food challenge and a visual analog scale in the etiologic diagnosis of eosinophilic esophagitis. (23654083)
2013
8
Eosinophilic esophagitis in a child with juvenile polyposis syndrome: is there a link? (23969542)
2013
9
Effectiveness of serological markers of eosinophil activity in monitoring eosinophilic esophagitis. (24274443)
2013
10
Eosinophilic esophagitis: a clinical, endoscopic, and histopathologic review. (23025974)
2012
11
Eosinophilic esophagitis and food impaction: an instructive case. (22798122)
2012
12
Intramural esophageal dissection in a young man with eosinophilic esophagitis. (21959190)
2012
13
Endoscopic findings in patients with Schatzki rings: evidence for an association with eosinophilic esophagitis. (23322994)
2012
14
Prevalence, clinical manifestations and endoscopic features of eosinophilic esophagitis: a pathological review in China. (22624553)
2012
15
Pediatric and adult eosinophilic esophagitis: similarities and differences. (22313241)
2012
16
Eosinophilic esophagitis: diagnostic tests and criteria. (22450900)
2012
17
An unusual complication of eosinophilic esophagitis in an adolescent: intramural esophageal dissection. (23169045)
2012
18
Eosinophilic esophagitis--recognition, diet and drugs. (22891174)
2012
19
Eosinophilic Esophagitis: update on treatment approaches. (23935283)
2012
20
Identification of clinical and laboratory markers for predicting eosinophilic esophagitis in adults. (22075653)
2011
21
Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis. (21277394)
2011
22
Eosinophilic esophagitis. (22165816)
2011
23
Esophageal subepithelial fibrosis and hyalinization are features of eosinophilic esophagitis. (21206380)
2011
24
Management of children who have eosinophilic esophagitis. (21670712)
2011
25
Tissue remodeling in patients with eosinophilic esophagitis: what lies beneath the surface? (22036097)
2011
26
Prevalence of eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease symptoms: A prospective study. (20843755)
2011
27
Emerging management concepts for eosinophilic esophagitis in children. (21545525)
2011
28
Eosinophilic esophagitis in patients with typical gastroesophageal reflux disease symptoms refractory to proton pump inhibitor. (21655746)
2011
29
Escalating incidence of eosinophilic esophagitis: a 20-year prospective, population-based study in Olten County, Switzerland. (22019091)
2011
30
Montelukast was inefficient in maintaining steroid-induced remission in adult eosinophilic esophagitis. (21674173)
2011
31
Gastroesophageal reflux, eosinophilic esophagitis, and foreign body. (21111120)
2010
32
Eosinophilic esophagitis: clinical features, endoscopic findings and response to treatment. (21152459)
2010
33
Esophageal polyp in a boy with eosinophilic esophagitis. (20818263)
2010
34
Eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease. (19241170)
2010
35
Comparison of esomeprazole to aerosolized, swallowed fluticasone for eosinophilic esophagitis. (19533356)
2010
36
Non-surgical interventions for eosinophilic esophagitis. (20238328)
2010
37
Increased HLA-DR expression on tissue eosinophils in eosinophilic esophagitis. (20639774)
2010
38
Gastroesophageal reflux disease and eosinophilic esophagitis in infants and children. A study of esophageal pH, multiple intraluminal impedance and endoscopic ultrasound. (20504244)
2010
39
Re: Might the use of acid-suppressive medications predispose to the development of eosinophilic esophagitis? (20139879)
2010
40
Vitamin D deficiency, eosinophilic esophagitis, and health literacy. (19797953)
2009
41
Eosinophilic esophagitis: concepts, controversies, and evidence. (19463222)
2009
42
Otolaryngologists may not be doing enough to diagnose pediatric eosinophilic esophagitis. (19732967)
2009
43
Psychological impact of eosinophilic esophagitis on children and families. (19141345)
2009
44
An unusual presentation of eosinophilic esophagitis. (19559423)
2009
45
Eosinophilic esophagitis: a prevalent disease in the United States that affects all age groups. (18471509)
2008
46
Eosinophilic esophagitis: analysis of food impaction and perforation in 251 adolescent and adult patients. (18407800)
2008
47
Overlap of reflux and eosinophilic esophagitis in two patients requiring different therapies: a review of the literature. (18322968)
2008
48
Current concepts and treatment options in eosinophilic esophagitis. (17117587)
2006
49
Eosinophilic esophagitis. (16282772)
2005
50
Montelukast reduces peripheral blood eosinophilia but not tissue eosinophilia or symptoms in a patient with eosinophilic gastroenteritis and esophageal stricture. (12546333)
2003

Genetic Variations for Eosinophilic Esophagitis

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Expression for genes affiliated with Eosinophilic Esophagitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilic Esophagitis

Search GEO for disease gene expression data for Eosinophilic Esophagitis.

Pathways for genes affiliated with Eosinophilic Esophagitis

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Sources:
52R&D Systems, 37NCBI BioSystems Database, 59Tocris Bioscience, 12EMD Millipore, 29KEGG, 51QIAGEN, 53Reactome
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Pathways related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IL5, IL13
210.3VCAM1, STAT6
310.2CCL11, CCL26, IL5
410.2TSLP, STAT6, CCL11
5
Hide members
10.2IL5RA, IL5, IL13
6
Hide members
10.1CCL11, STAT6, IL13, IL5
7
Hide members
10.1HLA-DQA1, STAT6, IL13, IL5
8
Hide members
10.1CCR3, CCL26, CCL11, CCL24
9
Hide members
10.1CCL24, CCL11, CCL26, CCR3
10
Immune response CCR3 signaling in eosinophils
Hide members
10.1CCL24, CCL11, CCL26, CCR3
11
Hide members
10.0HLA-DQA1, IL5, IL5RA, VCAM1
129.8STAT6, IL13, IL15RA, IL5, IL5RA, TSLP
13
Hide members
9.8CCL24, CCL11, CCL26, STAT6, IL13, IL15RA
14
Hide members
9.8CCL24, CCL11, CCL26, CCR3, STAT6, PRG2
15
Hide members
9.7IL5, CCL11, HLA-DQA1, PRG2, RNASE3, IL13
16
Hide members
9.6CCL24, CCL11, CCL26, CCR3, IL13, IL15RA
17
Hide members
9.6CCL24, CCL26, CCR3, STAT6, PRG2, IL15RA
18
Hide members
9.6CCL24, CCL11, CCL26, CCR3, IL13, IL15RA
19
Hide members
9.5CCL24, CCL11, CCL26, CCR3, STAT6, IL13

Compounds for genes affiliated with Eosinophilic Esophagitis

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1pge24410.8CCL11
2rantes4410.7CCL11, RNASE3
3unicap4410.6RNASE3, CCL11, IL5
4mometasone furoate44 5911.6VCAM1, IL5, RNASE3
5lte44410.5CCL11, IL5, RNASE3
6beclomethasone dipropionate4410.5VCAM1, IL5, RNASE3
7hematoxylin4410.5PRG2, IVL
8salmeterol44 49 28 1113.5IL13, RNASE3, IL5, CCL11
9cetirizine44 28 11 2413.5IL5, CCL11, RNASE3
10sodium cromoglycate4410.5VCAM1, CCL11, RNASE3, IL5
11montelukast44 49 28 1113.5CCL11, RNASE3, IL13, IL5
12ltd44410.5RNASE3, IL5, IL13, CCR3
13pranlukast44 28 1112.5RNASE3, CCL11, IL5
144-ipp5910.5IL5, IL13, IL5RA
15praziquantel44 1111.5RNASE3, IL5, IL13
16git 275910.5IL5, IL13, IL5RA
17ketotifen44 1111.4IL5, CCL11, RNASE3
18salbutamol44 49 28 11 2414.4IL13, VCAM1, IL5, RNASE3, CCL11
19ltc44410.4IL13, RNASE3, IL5, PRG2, CCL11
20ccl344 2811.4CCR3, CCL26, CCL11, IL13, CCL24
21methacholine44 1111.4IL13, RNASE3, PRG2, IL5, CCL11
22pirfenidone44 5911.4IL5, IL13, IL5RA
23prednisolone44 28 1112.4CCL11, RNASE3, IL13, IL5, VCAM1
24fluticasone propionate44 49 59 1113.4CCL11, VCAM1, IL5, IL13, STAT6, RNASE3
25pgd24410.3IL5, CCR3, CCL11, PRG2, RNASE3, IL13
26as 10159 4411.3IL5, IL13, IL5RA
27budesonide44 49 1112.3RNASE3, IL13, CCL11, IL5, VCAM1, IL5RA
28fmlp4410.3CCL11, PRG2, RNASE3, IL13, IL5, VCAM1
29oxygen44 2411.3IVL, PRG2, CCR3, CCL11, CCL26
30tarc4410.3IL5, TSLP, CCL24, CCL11, CCL26, CCR3
31heparin44 28 11 2413.2CCL11, VCAM1, CCR3, PRG2, RNASE3, IL13
32actinomycin d4410.2IL13, PRG2, STAT6, CCR3, CCL11, CCL24
33sb 20358044 5911.2IVL, MUC5AC, CCL11, STAT6, IL13, IL5
34leukotriene b444 59 2412.1IL13, IL5, RNASE3, CCL11
35superoxide44 2411.0CCL24, VCAM1, CCL11, IL5RA, PRG2, CCL26
36allergens4410.0CCL11, IL5, TSLP, IL13, RNASE3, IVL
37n acetylcysteine4410.0RNASE3, MUC5AC, CCL11, STAT6, VCAM1
38arginine4410.0IL5, VCAM1, RNASE3, HLA-DQA1, IL13, IL5RA
39phosphatidylinositol449.9IVL, STAT6, MUC5AC, IL13, CCL11, VCAM1
40butyrate449.9CCL11, IL5, CCR3
41polysaccharide449.9RNASE3, MUC5AC, IVL, IL13, VCAM1
42cysteine449.9MUC5AC, IVL, CCL26, PRG2, FLG, CCR3
43steroid449.9IL5RA, IL13, CCL24, CCL11, STAT6, FLG
44histamine44 28 2411.9STAT6, MUC5AC, CCL11, CCL24, PRG2, RNASE3
45dexamethasone44 49 28 1112.8VCAM1, IL5RA, IL13, RNASE3, IL5, MUC5AC
46nitric oxide44 11 2411.8CCL11, FLG, PRG2, MUC5AC, RNASE3, IL13
47adenylate449.8RNASE3, CCR3, IVL, IL13, IL5, VCAM1
48calcium44 49 11 2412.7CCL26, FLG, SPRR3, RNASE3, MUC5AC, IVL
49retinoic acid44 2410.5SPRR3, CCL11, PRG2, VCAM1, IL5, IL13
50tyrosine449.5RNASE3, IL13, CCL11, IL5, MUC5AC, IVL

GO Terms for genes affiliated with Eosinophilic Esophagitis

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16Gene Ontology
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Cellular components related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.4TSLP, CCL11, CCL26, CCR3, IL13, IL15RA

Biological processes related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1mast cell chemotaxisGO:00255110.5CCR3, CCL11
2eosinophil chemotaxisGO:04824510.5CCR3, CCL11, CCL24
3positive regulation of Rac GTPase activityGO:03285510.4CCL26, CCL11, CCL24
4positive regulation of actin filament polymerizationGO:03083810.4CCL24, CCL11, CCL26
5positive regulation of endothelial cell proliferationGO:00193810.4CCL24, CCL11, CCL26, CCR3
6chronic inflammatory responseGO:00254410.3VCAM1, CCL11
7keratinocyte differentiationGO:03021610.3SPRR3, IVL, FLG
8ERK1 and ERK2 cascadeGO:07037110.3CCR3, CCL11
9chemotaxisGO:00693510.3CCL24, CCL11, CCL26, CCR3, RNASE2
10inflammatory responseGO:00695410.2CCL24, CCL11, CCL26, CCR3, IL13, IL5
11positive regulation of angiogenesisGO:04576610.2CCL24, CCL11, CCR3
12cytokine-mediated signaling pathwayGO:01922110.1VCAM1, IL5, IL15RA, HLA-DQA1
13immune responseGO:00695510.1IL5, IL13, PRG2, HLA-DQA1, CCL26, CCL11
14positive regulation of cell migrationGO:03033510.1CCL26, CCL11, CCL24
15cell adhesionGO:00715510.1CCL11, CCR3, MUC5AC, SIGLEC8, VCAM1
16RNA catabolic processGO:0064019.9RNASE2, RNASE3
17signal transductionGO:0071659.9CCL24, CCL11, CCL26, STAT6, IL13, IL15RA

Molecular functions related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pancreatic ribonuclease activityGO:00452210.2RNASE2, RNASE3
2chemokine activityGO:00800910.1CCL26, CCL11, CCL24
3ribonuclease activityGO:0045409.9RNASE2, RNASE3

Products for genes affiliated with Eosinophilic Esophagitis

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  • Antibodies
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Sources for Eosinophilic Esophagitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet