EOE
MCID: ESN001
MIFTS: 53

Eosinophilic Esophagitis (EOE) malady

Gastrointestinal diseases, Rare diseases categories

Summaries for Eosinophilic Esophagitis

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Sources:
66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Eosinophilic esophagitis (eosinophilic oesophagitis), also known as allergic oesophagitis, is an... more...

MalaCards: Eosinophilic Esophagitis, also known as EOE, is related to esophagitis and food allergy. An important gene associated with Eosinophilic Esophagitis is CCL26 (chemokine (C-C motif) ligand 26), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and TSLP Signaling Pathway. The compounds omalizumab and ovomucoid have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin, and related mouse phenotype respiratory system.

Description from OMIM:48 610247,613412

Aliases & Classifications for Eosinophilic Esophagitis

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Sources:
9Disease Ontology, 11DISEASES, 50Orphanet, 48OMIM, 63UMLS, 28ICD9CM, 36MeSH, 41NCIt, 59SNOMED-CT, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

50
eosinophilic esophagitis:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

eosinophilic esophagitis 9 11 50 48 63
eoe 50


External Ids:

Disease Ontology9 DOID:13922
ICD9CM28 530.13
MeSH36 D057765
NCIt41 C27105
SNOMED-CT59 235599003
MESH via Orphanet37 D057765
ICD10 via Orphanet27 K20
SNOMED-CT via Orphanet60 235599003
UMLS via Orphanet64 C0341106

Related Diseases for Eosinophilic Esophagitis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Eosinophilic Esophagitis family:

Esophagitis, Eosinophilic, 2 Esophagitis, Eosinophilic, 1

Diseases related to Eosinophilic Esophagitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis32.0CCL26, CCL11, IL5, IL13
2food allergy30.7CCL11, IL5, IL13
3eosinophilia30.7CCL26, CCL11, IL5, IL13
4eosinophilic gastroenteritis30.5CCL11, IL5
5asthma30.1IL5, IL13
6hypereosinophilic syndrome30.1CCL11, IL5
7gastroesophageal reflux disease10.6
8celiac disease10.5
9dysphagia10.5
10barrett's esophagus10.4
11gastroenteritis10.4
12esophageal atresia10.3
13esophageal candidiasis10.2
14candidiasis10.2
15herpes simplex10.2
16eosinophilic enteropathy10.2
17churg-strauss syndrome10.1IL5
18strongyloidiasis10.1IL5
19folliculitis10.1CCL11
20extraskeletal ewing sarcoma10.0
21gamma chain deficiency10.0IL13, TSLP
22helminthiasis10.0IL5, IL13
23filariasis10.0IL13, IL5
24cutaneous leishmaniasis10.0IL5, IL13
25chronic eosinophilic pneumonia10.0IL5, CCL11
26giant papillary conjunctivitis10.0CCL11, IL5
27mastocytosis10.0IL13, IL5
28crohn's disease10.0
29rubinstein-taybi syndrome10.0
30cystic fibrosis10.0
31diffuse idiopathic skeletal hyperostosis10.0
32pharyngitis10.0
33granular cell tumor10.0
34duodenitis10.0
35achalasia10.0
36juvenile polyposis syndrome10.0
37arthritis10.0
38esophageal disease10.0
39gastritis10.0
40hyperostosis10.0
41inflammatory bowel disease10.0
42laryngitis10.0
43pulmonary embolism10.0
44rheumatoid arthritis10.0
45inflammatory myofibroblastic tumor10.0
46laryngeal papillomatosis10.0
47tracheoesophageal fistula10.0
48esophageal squamous cell carcinoma10.0
49blindness10.0
50leishmaniasis10.0IL5, IL13

Graphical network of the top 20 diseases related to Eosinophilic Esophagitis:



Diseases related to eosinophilic esophagitis

Symptoms for Eosinophilic Esophagitis

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Sources:
48OMIM
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Symptoms by clinical synopsis from OMIM:

610247

Clinical features from OMIM:

610247,613412

Drugs & Therapeutics for Eosinophilic Esophagitis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Eosinophilic Esophagitis

Drug clinical trials:

Search ClinicalTrials for Eosinophilic Esophagitis

Search NIH Clinical Center for Eosinophilic Esophagitis

Search CenterWatch for Eosinophilic Esophagitis

Genetic Tests for Eosinophilic Esophagitis

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Anatomical Context for Eosinophilic Esophagitis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Eosinophilic Esophagitis:

34
Testes, T cells, Skin, Lymph node, Smooth muscle

Animal Models for Eosinophilic Esophagitis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Eosinophilic Esophagitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.4IL13, IL5, CCL11, TSLP

Publications for Eosinophilic Esophagitis

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Sources:
53PubMed
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Articles related to Eosinophilic Esophagitis:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Are major basic protein, eotaxin-3 and leukotriene enzyme staining useful for diagnosing eosinophilic esophagitis? (Am j gastroenterol 2012;107:1503-1511). (23350059)
2013
2
Practical management of eosinophilic esophagitis. (23805960)
2013
3
Causes, evaluation, and consequences of eosinophilic esophagitis. (24117638)
2013
4
Molecular diagnosis of eosinophilic esophagitis by gene expression profiling. (23978633)
2013
5
a8^a8^mTechnetium-labeled heparin: a new approach to detection of eosinophilic esophagitis-associated inflammation. (23895898)
2013
6
Eosinophilic esophagitis: is it also a surgical disease? (23414856)
2013
7
The pathogenesis of eosinophilic esophagitis: beyond the eosinophil. (23625288)
2013
8
Serum Eosinophil Cationic Protein is Superior to Mast Cell Tryptase as Marker for Response to Topical Corticosteroid Therapy in Eosinophilic Esophagitis. (24177377)
2013
9
Frequent sensitization to Candida albicans and profilins in adult eosinophilic esophagitis. (23735202)
2013
10
Immunoreactivity of p53 and Ki-67 for dysplastic changes in children with eosinophilic esophagitis. (23718721)
2013
11
Clinical analysis of primary eosinophilic esophagitis. (23667751)
2013
12
A case of eosinophilic esophagitis discovered with positron emission tomography imaging: a case report. (23855975)
2013
13
T cell co-stimulatory molecules: a co-conspirator in the pathogenesis of eosinophilic esophagitis? (23456499)
2013
14
Dietary therapies for eosinophilic esophagitis. (24236700)
2013
15
Diagnosis and management of eosinophilic esophagitis. (22728382)
2012
16
Transient PPI responsive esophageal eosinophilia may be a clinical sub-phenotype of pediatric eosinophilic esophagitis. (22134787)
2012
17
Eosinophilic esophagitis: a clinical, endoscopic, and histopathologic review. (23025974)
2012
18
Esophageal functional impairments in experimental eosinophilic esophagitis. (22361731)
2012
19
The otolaryngologic manifestations in children with eosinophilic esophagitis. (22093742)
2012
20
Selective elimination diet based on skin testing has suboptimal efficacy for adult eosinophilic esophagitis. (22867695)
2012
21
Fluoroscopic findings in pediatric eosinophilic esophagitis. (22241596)
2012
22
Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. (21570716)
2011
23
Fluticasone and food allergen elimination reverse sub-epithelial fibrosis in children with eosinophilic esophagitis. (20458625)
2011
24
Boerhaave's syndrome as the primary manifestation of adult eosinophilic esophagitis. Two case reports and a review of the literature. (21309916)
2011
25
Medication-induced esophageal tattoo in a patient with eosinophilic esophagitis. (20619833)
2011
26
The natural history and complications of eosinophilic esophagitis. (22040638)
2011
27
Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methods. (22099448)
2011
28
Variable reliability of endoscopic findings with white-light and narrow-band imaging for patients with suspected eosinophilic esophagitis. (21377547)
2011
29
Severe dysphagia in children with eosinophilic esophagitis and esophageal stricture: an indication for balloon dilation? (19934772)
2010
30
Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. (20371398)
2010
31
Do eosinophil numbers differentiate eosinophilic esophagitis from gastroesophageal reflux disease? (20524860)
2010
32
Defining the role of food allergy in a population of adult patients with eosinophilic esophagitis. (20887270)
2010
33
Gastroesophageal reflux, eosinophilic esophagitis, and foreign body. (21111120)
2010
34
Acid-suppressive therapy and eosinophilic esophagitis: friends or foes? (20203650)
2010
35
Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis. (20815913)
2010
36
Eosinophilic esophagitis: clinical features, endoscopic findings and response to treatment. (21152459)
2010
37
Image of the month. Gone fishin': a surprising finding while investigating possible eosinophilic esophagitis. (20683199)
2010
38
A case-control study of sociodemographic and geographic characteristics of 335 children with eosinophilic esophagitis. (19118642)
2009
39
Eosinophilic esophagitis: the newest esophageal inflammatory disease. (19404267)
2009
40
Vitamin D deficiency, eosinophilic esophagitis, and health literacy. (19797953)
2009
41
Eosinophilic esophagitis. (19115464)
2009
42
Clinical evaluation of the adult who has eosinophilic esophagitis. (19141337)
2009
43
Pharmacologic treatment of eosinophilic esophagitis. (18061110)
2008
44
Eosinophilic esophagitis and intermediate esophagitis after tracheoesophageal fistula repair: a case series. (18485944)
2008
45
Eosinophilic esophagitis : a cause of dysphagia]. (18214405)
2008
46
Demographic data and symptoms of eosinophilic esophagitis in adults. (18061099)
2008
47
Eosinophilic esophagitis--pathogenesis, clinical presentation and therapeutic management]. (18080228)
2007
48
Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. (17919504)
2007
49
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. (16453027)
2006
50
Eosinophilic esophagitis. (16606552)
2006

Variations for Eosinophilic Esophagitis

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Expression for genes affiliated with Eosinophilic Esophagitis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilic Esophagitis

Search GEO for disease gene expression data for Eosinophilic Esophagitis.

Pathways for genes affiliated with Eosinophilic Esophagitis

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Sources:
51PathCards, 55R&D Systems, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 62Tocris Bioscience, 13EMD Millipore, 31KEGG
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Pathways related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5CCL11, CCL26
29.4TSLP, CCL11
39.4IL13, IL5
49.4IL13, IL5
5
Show member pathways
9.4IL13, IL5
69.4IL13, IL5
79.4IL13, IL5
89.4IL5, IL13
99.3IL5, CCL11
10
Show member pathways
Type III interferon signaling39
9.0TSLP, IL5, IL13
119.0CCL26, CCL11, IL5
12
Show member pathways
8.8CCL11, IL5, IL13
13
Show member pathways
8.7CLDN1, CCL26, CCL11
14
Show member pathways
8.4CCL26, CCL11, IL5, IL13
15
Show member pathways
8.4CCL26, CCL11, IL5, IL13
16
Show member pathways
8.4CCL26, CCL11, IL5, IL13
17
Show member pathways
8.4CCL26, CCL11, IL5, IL13
18
Show member pathways
8.0IL13, IL5, CCL11, CCL26, TSLP

Compounds for genes affiliated with Eosinophilic Esophagitis

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 52PharmGKB
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Compounds related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show top 50)    (show all 68)
idCompoundScoreTop Affiliating Genes
1omalizumab46 1210.9IL13, IL5
2ovomucoid469.8IL13, IL5
34-ipp629.8IL13, IL5
4git 27629.8IL5, IL13
5glatiramer acetate46 1210.8IL13, IL5
6praziquantel46 1210.8IL13, IL5
7pirfenidone46 6210.8IL5, IL13
8unicap469.7IL5, CCL11
9penicillin469.7IL13, IL5
10amphotericin b469.7IL5, IL13
11sodium cromoglycate469.7CCL11, IL5
12lte4469.7CCL11, IL5
13as 10146 6210.7IL5, IL13
145-oxoete469.7CCL11, IL5
15roxithromycin46 30 1211.7CCL11, IL5
16cetirizine46 30 25 1212.7CCL11, IL5
17ltd4469.7IL13, IL5
18il-12469.7IL5, IL13
19pranlukast46 30 1211.7CCL11, IL5
20ketotifen46 1210.7CCL11, IL5
21clarithromycin46 1210.6CCL11, IL5
22gm-csf46 3010.5IL5, IL13
23groalpha469.5CCL11, IL13
24nickel46 2510.4IL5, IL13
25ccl346 3010.4IL13, CCL11, CCL26
26salmeterol46 52 30 1212.3CCL11, IL5, IL13
27montelukast46 52 30 1212.3IL13, IL5, CCL11
28ltc4469.3CCL11, IL13, IL5
29budesonide46 52 1211.3IL5, CCL11, IL13
30salbutamol46 52 30 25 1213.2IL5, IL13, CCL11
31fluticasone propionate46 52 62 1212.2IL13, IL5, CCL11
32rolipram46 62 3011.2IL13, IL5, CCL11
33pgd2469.2CCL11, IL5, IL13
34methacholine46 52 1211.2CCL11, IL5, IL13
35leukotriene b446 62 2511.2IL5, IL13, CCL11
36prednisolone46 30 1211.2CCL11, IL5, IL13
37ionomycin469.2IL5, IL13, CCL11
38fmlp469.2IL13, IL5, CCL11
39tacrolimus46 52 1211.2IL13, IL5, CCL11
40indomethacin46 30 62 1212.0IL5, IL13, CCL11
41poly(i-c)469.0IL5, CCL11
42sb 20358046 6210.0IL5, CCL11, IL13
43histamine46 30 2511.0CCL11, IL13, IL5
44ly294002468.9IL13, IL5, CCL11
45rantes468.9IL5, CCL26, IL13, CCL11
46allergens468.9TSLP, CCL11, IL5, IL13
47pge2468.8CCL11, IL13, IL5
48cyclosporin a46 30 6210.7IL13, CCL11, IL5
49retinoic acid46 259.6CCL11, IL5, SPRR3, IL13
50tarc468.5TSLP, IL13, IL5, CCL11, CCL26

GO Terms for genes affiliated with Eosinophilic Esophagitis

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Sources:
17Gene Ontology
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Cellular components related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.0IL13, IL5, CCL11, CCL26, TSLP

Biological processes related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of Rac GTPase activityGO:0328559.6CCL11, CCL26
2positive regulation of B cell proliferationGO:0308909.5IL5, IL13
3positive regulation of actin filament polymerizationGO:0308389.5CCL11, CCL26
4positive regulation of cell migrationGO:0303359.5CCL11, CCL26
5positive regulation of endothelial cell proliferationGO:0019389.4CCL11, CCL26
6chemotaxisGO:0069359.2CCL11, CCL26
7inflammatory responseGO:0069548.6IL13, IL5, CCL11, CCL26
8immune responseGO:0069558.6CCL26, CCL11, IL5, IL13

Molecular functions related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.5CCL11, CCL26
2cytokine activityGO:0051258.7IL13, IL5, TSLP

Products for genes affiliated with Eosinophilic Esophagitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eosinophilic Esophagitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet