MCID: ESN001
MIFTS: 52

Eosinophilic Esophagitis malady

Gastrointestinal category

Summaries for Eosinophilic Esophagitis

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Eosinophilic esophagitis (eosinophilic oesophagitis) is an allergic inflammatory condition of the... more...

MalaCards: Eosinophilic Esophagitis is related to celiac disease and eosinophilic gastroenteritis. An important gene associated with Eosinophilic Esophagitis is CCL26 (chemokine (C-C motif) ligand 26), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds pge2 and rantes have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and smooth muscle, and related mouse phenotypes are respiratory system and hematopoietic system.

Description from OMIM:47 610247,613412

Aliases & Classifications for Eosinophilic Esophagitis

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 47OMIM, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
eosinophilic esophagitis:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

eosinophilic esophagitis 8 10 49 47 61


External Ids:

Disease Ontology8 DOID:13922
ICD9CM27 530.13
NCIt40 C27105
MeSH35 D057765
SNOMED-CT57 235599003
MESH via Orphanet36 D057765
ICD10 via Orphanet26 K20
SNOMED-CT via Orphanet58 235599003
UMLS via Orphanet62 C0341106

Related Diseases for Eosinophilic Esophagitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Eosinophilic Esophagitis family:

esophagitis, eosinophilic, 2 esophagitis, eosinophilic, 1

Diseases related to Eosinophilic Esophagitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1celiac disease30.7HLA-DQA1
2eosinophilic gastroenteritis30.6CCL11, IL5
3hypereosinophilic syndrome30.0CCL11, PRG2, RNASE3, IL5
4asthma30.0CCL11, IL13
5arthritis30.0CCR3, STAT6, FLG, IL13
6cystic fibrosis30.0HLA-DQA1, MUC5AC, RNASE3
7gastroesophageal reflux disease10.6
8dysphagia10.5
9esophagitis, eosinophilic, 210.3
10esophageal atresia10.2
11eosinophilic enteropathy10.2
12esophageal candidiasis10.2
13boerhaave syndrome10.2
14esophagitis, eosinophilic, 110.2
15diffuse idiopathic skeletal hyperostosis10.0
16rubinstein-taybi syndrome10.0
17achalasia10.0
18pharyngitis10.0
19granular cell tumor10.0
20eosinophilic gastritis10.0
21adult syndrome10.0
22juvenile polyposis syndrome10.0
23squamous cell carcinoma10.0
24tracheoesophageal fistula10.0
25inflammatory myofibroblastic tumor10.0
26laryngeal papillomatosis10.0
27celiac disease 210.0
28esophageal squamous cell carcinoma10.0
29hepatitis10.0CCL11
30dermatitis herpetiformis10.0CCL11
31conjunctivitis10.0RNASE3
32paragonimiasis10.0IL5
33hepatitis b10.0HLA-DQA1
34endometriosis10.0CCL11
35severe combined immunodeficiency10.0IL5
36bronchitis10.0RNASE3
37migraine10.0RNASE2
38onchocerciasis10.0IL5, RNASE3
39churg-strauss syndrome10.0IL5, RNASE3
40pemphigus vulgaris10.0CCL11, IVL
41uveitis10.0CCL11
42gastritis10.0MUC5AC
43urticaria10.0RNASE3, PRG2
44sjogren's syndrome10.0MUC5AC
45mastocytosis10.0IL5, IL13
46influenza10.0CCL11
47sarcoidosis10.0IL13, CCL11
48kimura disease10.0PRG2, RNASE3, IL5
49common cold10.0CCL11, RNASE3
50chronic eosinophilic pneumonia10.0IL5, RNASE3, CCL11

Graphical network of the top 20 diseases related to Eosinophilic Esophagitis:



Diseases related to eosinophilic esophagitis

Clinical Features for Eosinophilic Esophagitis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

610247,613412

Clinical synopsis from OMIM:

610247

Drugs & Therapeutics for Eosinophilic Esophagitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Eosinophilic Esophagitis

Drug clinical trials:

Search ClinicalTrials for Eosinophilic Esophagitis

Search NIH Clinical Center for Eosinophilic Esophagitis

Search CenterWatch for Eosinophilic Esophagitis

Genetic Tests for Eosinophilic Esophagitis

Anatomical Context for Eosinophilic Esophagitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Eosinophilic Esophagitis:

33
Skin, Lymph node, Smooth muscle, Skeletal muscle, Small intestine, T cells

Animal Models for Eosinophilic Esophagitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Eosinophilic Esophagitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.7CCL11, CCR3, STAT6, PRG2, IL13, IL5
2MP:00053978.8CCL24, CCL11, CCR3, HLA-DQA1, STAT6, FLG
3MP:00053878.7TSLP, CCL24, CCL11, CCR3, HLA-DQA1, STAT6

Publications for Eosinophilic Esophagitis

Sources:
51PubMed
See all sources

Articles related to Eosinophilic Esophagitis:

(show top 50)    (show all 519)
idTitleAuthorsYear
1
Management guidelines of eosinophilic esophagitis in childhood. (24378521)
2014
2
Are major basic protein, eotaxin-3 and leukotriene enzyme staining useful for diagnosing eosinophilic esophagitis? (Am j gastroenterol 2012;107:1503-1511). (23350059)
2013
3
Eosinophilic esophagitis in children and adolescents: epidemiology, clinical presentation and seasonal variation. (22618806)
2013
4
Development and validation of a registry-based definition of eosinophilic esophagitis in Denmark. (23382628)
2013
5
Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease. (23375693)
2013
6
FDG PET/CT in Eosinophilic Esophagitis. (23510886)
2013
7
ACG clinical guideline: Evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). (23567357)
2013
8
Prevalence and characteristics of eosinophilic esophagitis in 2 ethnically distinct pediatric populations. (24342547)
2013
9
Demographic, clinical and allergological characteristics of Eosinophilic Esophagitis in a Spanish central region. (23845923)
2013
10
Early life exposures as risk factors for pediatric eosinophilic esophagitis. (23518485)
2013
11
Association of achalasia and eosinophilic esophagitis. (23054948)
2013
12
Working with the US Food and Drug Administration: progress and timelines in understanding and treating patients with eosinophilic esophagitis. (22935588)
2012
13
Cow's milk elimination: a novel dietary approach to treat eosinophilic esophagitis. (22820121)
2012
14
Development of the Pediatric Quality of Life Inventorya8c Eosinophilic Esophagitis module items: qualitative methods. (23009120)
2012
15
Eosinophilic Esophagitis in Pediatrics: The Worst of all Possible Allergy Worlds? (21941576)
2012
16
Eosinophilic esophagitis for the otolaryngologist. (22220173)
2012
17
An unusual complication of eosinophilic esophagitis in an adolescent: intramural esophageal dissection. (23169045)
2012
18
Eosinophilic esophagitis--recognition, diet and drugs. (22891174)
2012
19
Esophageal motor disorders in adults with eosinophilic esophagitis. (21416245)
2011
20
A striking local esophageal cytokine expression profile in eosinophilic esophagitis. (21211656)
2011
21
Eosinophilic esophagitis. (22235452)
2011
22
Eosinophilic esophagitis, celiac disease, and immunoglobulin E-mediated allergy in a 2-year-old child. (21370728)
2011
23
A novel balloon pull-through technique for esophageal dilation in eosinophilic esophagitis (with video). (21184880)
2011
24
Eosinophilic esophagitis: update on clinicopathological manifestations and pathophysiology. (21577101)
2011
25
Dysphagia and quality of life may improve with mometasone treatment in patients with eosinophilic esophagitis: a pilot study. (21593463)
2011
26
Antigen presentation and MHC class II expression by human esophageal epithelial cells: role in eosinophilic esophagitis. (21281807)
2011
27
Prevalence of eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease symptoms: A prospective study. (20843755)
2011
28
Therapeutic options for eosinophilic esophagitis. (21346856)
2011
29
Escalating incidence of eosinophilic esophagitis: a 20-year prospective, population-based study in Olten County, Switzerland. (22019091)
2011
30
Montelukast was inefficient in maintaining steroid-induced remission in adult eosinophilic esophagitis. (21674173)
2011
31
Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. (20371398)
2010
32
Acid-suppressive therapy and eosinophilic esophagitis: friends or foes? (20203650)
2010
33
Medical and nutrition management of eosinophilic esophagitis in children. (20413697)
2010
34
Approach to dysphagia in the young patient in the era of eosinophilic esophagitis. (20431968)
2010
35
Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids. (19796194)
2010
36
Esophageal dilation: simple and effective treatment for adults with eosinophilic esophagitis and esophageal rings and narrowing. (20353444)
2010
37
PPIs may not predispose to eosinophilic esophagitis. (20139878)
2010
38
Eosinophilic esophagitis. (19115464)
2009
39
Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease. (19733260)
2009
40
Exploring the role of mast cells in eosinophilic esophagitis. (19141354)
2009
41
Mechanism of eosinophilic esophagitis. (19141339)
2009
42
Curious elements of esophageal foreign body impaction and eosinophilic esophagitis. (20567528)
2009
43
14 years of eosinophilic esophagitis: clinical features and prognosis. (19172120)
2009
44
An unusual presentation of eosinophilic esophagitis. (19559423)
2009
45
Eosinophilic esophagitis and intermediate esophagitis after tracheoesophageal fistula repair: a case series. (18485944)
2008
46
Demographic data and symptoms of eosinophilic esophagitis in adults. (18061099)
2008
47
Eosinophilic esophagitis in adults. (18499024)
2008
48
3-yr-follow-up of topical corticosteroid treatment for eosinophilic esophagitis in adults. (18637093)
2008
49
Eosinophilic esophagitis. (17914050)
2007
50
Eosinophilic esophagitis: A subset of eosinophilic gastroenteritis. (10980958)
1999

Genetic Variations for Eosinophilic Esophagitis

Expression for genes affiliated with Eosinophilic Esophagitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Eosinophilic Esophagitis

Search GEO for disease gene expression data for Eosinophilic Esophagitis.

Pathways for genes affiliated with Eosinophilic Esophagitis

Sources:
53R&D Systems, 38NCBI BioSystems Database, 60Tocris Bioscience, 12EMD Millipore, 30KEGG, 52QIAGEN, 54Reactome
See all sources

Pathways related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IL5, IL13
210.3VCAM1, STAT6
310.2CCL11, CCL26, IL5
410.2TSLP, STAT6, CCL11
5
Hide members
10.2IL5RA, IL5, IL13
6
Hide members
10.1CCL11, STAT6, IL13, IL5
7
Hide members
10.1HLA-DQA1, STAT6, IL13, IL5
8
Hide members
10.1CCR3, CCL26, CCL11, CCL24
9
Hide members
10.1CCL24, CCL11, CCL26, CCR3
10
Immune response CCR3 signaling in eosinophils
Hide members
10.1CCL24, CCL11, CCL26, CCR3
11
Hide members
10.0HLA-DQA1, IL5, IL5RA, VCAM1
129.8STAT6, IL13, IL15RA, IL5, IL5RA, TSLP
13
Hide members
9.8CCL24, CCL11, CCL26, STAT6, IL13, IL15RA
14
Hide members
9.8CCL24, CCL11, CCL26, CCR3, STAT6, PRG2
15
Hide members
9.7IL5, CCL11, HLA-DQA1, PRG2, RNASE3, IL13
16
Hide members
9.6CCL24, CCL11, CCL26, CCR3, IL13, IL15RA
17
Hide members
9.6CCL24, CCL26, CCR3, STAT6, PRG2, IL15RA
18
Hide members
9.6CCL24, CCL11, CCL26, CCR3, IL13, IL15RA
19
Hide members
9.5CCL24, CCL11, CCL26, CCR3, STAT6, IL13

Compounds for genes affiliated with Eosinophilic Esophagitis

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1pge24510.8CCL11
2rantes4510.7RNASE3, CCL11
3unicap4510.6CCL11, RNASE3, IL5
4mometasone furoate45 6011.6RNASE3, IL5, VCAM1
5lte44510.5CCL11, RNASE3, IL5
6beclomethasone dipropionate4510.5RNASE3, IL5, VCAM1
7hematoxylin4510.5IVL, PRG2
8salmeterol45 50 29 1113.5IL5, IL13, RNASE3, CCL11
9cetirizine45 29 11 2413.5CCL11, RNASE3, IL5
10sodium cromoglycate4510.5CCL11, RNASE3, IL5, VCAM1
11montelukast45 50 29 1113.5CCL11, RNASE3, IL13, IL5
12ltd44510.5IL5, IL13, RNASE3, CCR3
13pranlukast45 29 1112.5CCL11, RNASE3, IL5
144-ipp6010.5IL13, IL5, IL5RA
15praziquantel45 1111.5IL5, IL13, RNASE3
16git 276010.5IL13, IL5, IL5RA
17ketotifen45 1111.4CCL11, RNASE3, IL5
18salbutamol45 50 29 11 2414.4VCAM1, IL5, IL13, RNASE3, CCL11
19ltc44510.4CCL11, PRG2, RNASE3, IL13, IL5
20ccl345 2911.4CCL24, CCL11, CCL26, CCR3, IL13
21methacholine45 1111.4CCL11, PRG2, RNASE3, IL13, IL5
22pirfenidone45 6011.4IL5RA, IL5, IL13
23prednisolone45 29 1112.4CCL11, RNASE3, IL13, IL5, VCAM1
24fluticasone propionate45 50 60 1113.4CCL11, STAT6, RNASE3, IL13, IL5, VCAM1
25pgd24510.3CCL11, CCR3, PRG2, RNASE3, IL13, IL5
26as 10160 4511.3IL5RA, IL5, IL13
27budesonide45 50 1112.3CCL11, RNASE3, IL13, IL5, IL5RA, VCAM1
28fmlp4510.3CCL11, PRG2, RNASE3, IL13, IL5, VCAM1
29oxygen45 2411.3IVL, PRG2, CCR3, CCL26, CCL11
30tarc4510.3CCL24, CCL11, CCL26, CCR3, IL13, IL5
31heparin45 29 11 2413.2CCL11, CCR3, PRG2, RNASE3, IL13, VCAM1
32actinomycin d4510.2CCL24, CCL11, CCR3, STAT6, PRG2, IL13
33sb 20358045 6011.2CCL11, STAT6, IVL, MUC5AC, IL13, IL5
34leukotriene b445 60 2412.1CCL11, RNASE3, IL13, IL5
35superoxide45 2411.0CCL24, CCL11, CCL26, PRG2, IL5RA, VCAM1
36allergens4510.0TSLP, CCL11, STAT6, FLG, PRG2, IVL
37n acetylcysteine4510.0CCL11, STAT6, MUC5AC, RNASE3, VCAM1
38arginine4510.0HLA-DQA1, FLG, PRG2, RNASE3, IL13, IL5
39phosphatidylinositol459.9CCL11, STAT6, IVL, MUC5AC, IL13, VCAM1
40butyrate459.9CCL11, CCR3, IL5
41polysaccharide459.9VCAM1, IL13, RNASE3, MUC5AC, IVL
42cysteine459.9CCL26, CCR3, FLG, PRG2, IVL, MUC5AC
43steroid459.9CCL24, CCL11, STAT6, FLG, IVL, MUC5AC
44histamine45 29 2411.9CCL24, CCL11, CCR3, STAT6, PRG2, MUC5AC
45dexamethasone45 50 29 1112.8CCL11, CCR3, STAT6, IVL, MUC5AC, RNASE3
46nitric oxide45 11 2411.8CCL11, FLG, PRG2, MUC5AC, RNASE3, IL13
47adenylate459.8VCAM1, IL5, IL13, RNASE3, IVL, CCR3
48calcium45 50 11 2412.7CCL24, CCL11, CCL26, CCR3, STAT6, FLG
49retinoic acid45 2410.5PRG2, FLG, STAT6, CCR3, CCL11, IVL
50tyrosine459.5PRG2, FLG, STAT6, CCR3, CCL11, IVL

GO Terms for genes affiliated with Eosinophilic Esophagitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.4TSLP, CCL11, CCL26, CCR3, IL13, IL15RA

Biological processes related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1mast cell chemotaxisGO:00255110.5CCR3, CCL11
2eosinophil chemotaxisGO:04824510.5CCR3, CCL11, CCL24
3positive regulation of Rac GTPase activityGO:03285510.4CCL26, CCL11, CCL24
4positive regulation of actin filament polymerizationGO:03083810.4CCL24, CCL11, CCL26
5positive regulation of endothelial cell proliferationGO:00193810.4CCL24, CCL11, CCL26, CCR3
6chronic inflammatory responseGO:00254410.3VCAM1, CCL11
7keratinocyte differentiationGO:03021610.3SPRR3, IVL, FLG
8ERK1 and ERK2 cascadeGO:07037110.3CCR3, CCL11
9chemotaxisGO:00693510.3CCL24, CCL11, CCL26, CCR3, RNASE2
10inflammatory responseGO:00695410.2CCL24, CCL11, CCL26, CCR3, IL13, IL5
11positive regulation of angiogenesisGO:04576610.2CCL24, CCL11, CCR3
12cytokine-mediated signaling pathwayGO:01922110.1VCAM1, IL5, IL15RA, HLA-DQA1
13immune responseGO:00695510.1IL5, IL13, PRG2, HLA-DQA1, CCL26, CCL11
14positive regulation of cell migrationGO:03033510.1CCL26, CCL11, CCL24
15cell adhesionGO:00715510.1CCL11, CCR3, MUC5AC, SIGLEC8, VCAM1
16RNA catabolic processGO:0064019.9RNASE2, RNASE3
17signal transductionGO:0071659.9CCL24, CCL11, CCL26, STAT6, IL13, IL15RA

Molecular functions related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pancreatic ribonuclease activityGO:00452210.2RNASE2, RNASE3
2chemokine activityGO:00800910.1CCL26, CCL11, CCL24
3ribonuclease activityGO:0045409.9RNASE2, RNASE3

Products for genes affiliated with Eosinophilic Esophagitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eosinophilic Esophagitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet