EOE
MCID: ESN001
MIFTS: 58

Eosinophilic Esophagitis (EOE) malady

Gastrointestinal diseases category

Summaries for Eosinophilic Esophagitis

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Eosinophilic esophagitis (eosinophilic oesophagitis), also known as allergic oesophagitis, is an... more...

MalaCards: Eosinophilic Esophagitis, also known as EOE, is related to esophagitis and celiac disease. An important gene associated with Eosinophilic Esophagitis is CCL26 (chemokine (C-C motif) ligand 26), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds pge2 and rantes have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin, and related mouse phenotypes are respiratory system and hematopoietic system.

Description from OMIM:46 610247,613412

Aliases & Classifications for Eosinophilic Esophagitis

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8Disease Ontology, 10DISEASES, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Characteristics (Orphanet epidemiological data):

48
eosinophilic esophagitis:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

eosinophilic esophagitis 8 10 48 46 60
eoe 48


External Ids:

Disease Ontology8 DOID:13922
ICD9CM27 530.13
NCIt39 C27105
MeSH34 D057765
SNOMED-CT56 235599003
MESH via Orphanet35 D057765
ICD10 via Orphanet26 K20
SNOMED-CT via Orphanet57 235599003
UMLS via Orphanet61 C0341106

Related Diseases for Eosinophilic Esophagitis

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17GeneCards, 18GeneDecks
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Diseases in the Eosinophilic Esophagitis family:

Esophagitis, Eosinophilic, 2 Esophagitis, Eosinophilic, 1

Diseases related to Eosinophilic Esophagitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1esophagitis32.0CCL11, CCL26, CCR3, PRG2, IL13, IL5
2celiac disease30.7HLA-DQA1
3food allergy30.7CCL11, RNASE3, IL13, IL5
4eosinophilia30.7VCAM1, CCL24, CCL11, CCL26, CCR3, STAT6
5eosinophilic gastroenteritis30.5CCL11, IL5
6gastritis30.0MUC5AC
7asthma29.9CCL11, IL13
8arthritis29.9CCR3, STAT6, FLG, IL13
9cystic fibrosis29.9HLA-DQA1, MUC5AC, RNASE3
10inflammatory bowel disease29.9CCL11, STAT6, MUC5AC, IL13, VCAM1
11rheumatoid arthritis29.9CCL11, CCR3, STAT6, FLG, PRG2, RNASE3
12esophageal disease10.8
13gastroesophageal reflux disease10.6
14barrett's esophagus10.4
15gastroenteritis10.4
16esophageal atresia10.2
17esophageal candidiasis10.1
18candidiasis10.1
19herpes simplex10.1
20eosinophilic enteropathy10.1
21extraskeletal ewing sarcoma10.0
22crohn's disease10.0
23diffuse idiopathic skeletal hyperostosis10.0
24rubinstein-taybi syndrome10.0
25achalasia10.0
26pharyngitis10.0
27granular cell tumor10.0
28eosinophilic gastritis10.0
29duodenitis10.0
30adult syndrome10.0
31juvenile polyposis syndrome10.0
32hyperostosis10.0
33intestinal disease10.0
34laryngitis10.0
35pulmonary embolism10.0
36squamous cell carcinoma10.0
37hepatitis10.0CCL11
38dermatitis herpetiformis10.0CCL11
39conjunctivitis10.0RNASE3
40paragonimiasis10.0IL5
41hepatitis b10.0HLA-DQA1
42endometriosis10.0CCL11
43severe combined immunodeficiency10.0IL5
44bronchitis10.0RNASE3
45migraine10.0RNASE2
46onchocerciasis10.0IL5, RNASE3
47churg-strauss syndrome10.0IL5, RNASE3
48pemphigus vulgaris10.0CCL11, IVL
49uveitis10.0CCL11
50urticaria10.0RNASE3, PRG2

Graphical network of the top 20 diseases related to Eosinophilic Esophagitis:



Diseases related to eosinophilic esophagitis

Clinical Features for Eosinophilic Esophagitis

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46OMIM
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Clinical features from OMIM:

610247,613412

Clinical synopsis from OMIM:

610247

Drugs & Therapeutics for Eosinophilic Esophagitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Eosinophilic Esophagitis

Drug clinical trials:

Search ClinicalTrials for Eosinophilic Esophagitis

Search NIH Clinical Center for Eosinophilic Esophagitis

Search CenterWatch for Eosinophilic Esophagitis

Genetic Tests for Eosinophilic Esophagitis

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Anatomical Context for Eosinophilic Esophagitis

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32MalaCards
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MalaCards organs/tissues related to Eosinophilic Esophagitis:

32
Testes, T cells, Skin, Lymph node, Lung, Smooth muscle

Animal Models for Eosinophilic Esophagitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eosinophilic Esophagitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.7CCL11, CCR3, STAT6, PRG2, IL13, IL5
2MP:00053978.8CCL24, CCL11, CCR3, HLA-DQA1, STAT6, FLG
3MP:00053878.7TSLP, CCL24, CCL11, CCR3, HLA-DQA1, STAT6

Publications for Eosinophilic Esophagitis

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50PubMed
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Articles related to Eosinophilic Esophagitis:

(show top 50)    (show all 531)
idTitleAuthorsYear
1
a8^a8^mTechnetium-labeled heparin: a new approach to detection of eosinophilic esophagitis-associated inflammation. (23895898)
2013
2
Development and validation of a registry-based definition of eosinophilic esophagitis in Denmark. (23382628)
2013
3
Eosinophilic esophagitis associated with laryngeal papillomatosis in a child. (23866678)
2013
4
Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease. (23375693)
2013
5
Clinical manifestations, treatment, and outcomes of children and adolescents with eosinophilic esophagitis. (23642431)
2013
6
Herpes simplex virus and eosinophilic esophagitis. (22343907)
2013
7
Health-care transition from pediatric to adult-focused gastroenterology in patients with eosinophilic esophagitis. (22309247)
2013
8
Functional luminal imaging probe topography: an improved method for characterizing esophageal distensibility in eosinophilic esophagitis. (23503784)
2013
9
Emerging concepts of dietary therapy for pediatric and adult eosinophilic esophagitis. (23557262)
2013
10
Diagnosis and management of eosinophilic esophagitis. (22728382)
2012
11
Cross-sector sponsorship of research in eosinophilic esophagitis: a collaborative model for rational drug development in rare diseases. (22857796)
2012
12
Race and eosinophilic esophagitis. (22764029)
2012
13
Eosinophilic esophagitis after esophageal atresia: is there an association? Case presentation and literature review. (22703825)
2012
14
Elimination diet effectively treats eosinophilic esophagitis in adults; food reintroduction identifies causative factors. (22391333)
2012
15
Management of pediatric eosinophilic esophagitis: an update. (22066717)
2012
16
The natural history and complications of eosinophilic esophagitis. (22040638)
2011
17
Eosinophilic esophagitis after specific oral tolerance induction for egg protein. (21195949)
2011
18
Eosinophilic esophagitis, celiac disease, and immunoglobulin E-mediated allergy in a 2-year-old child. (21370728)
2011
19
A novel balloon pull-through technique for esophageal dilation in eosinophilic esophagitis (with video). (21184880)
2011
20
Expression of mast cell-associated genes is upregulated in adult eosinophilic esophagitis and responds to steroid or dietary therapy. (21333344)
2011
21
Understanding eosinophilic esophagitis: the cellular and molecular mechanisms of an emerging disease. (21228772)
2011
22
Treatment of eosinophilic esophagitis: is oral viscous budesonide superior to swallowed fluticasone spray? (21346855)
2011
23
Immunophenotyping of peripheral eosinophils demonstrates activation in eosinophilic esophagitis. (21694534)
2011
24
Could be possible to predict eosinophil accumulation in esophageal mucosa in eosinophilic esophagitis without perform endoscopic examination? (21770690)
2011
25
Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis. (20815913)
2010
26
An update on the immunopathogenesis of eosinophilic esophagitis. (20350261)
2010
27
Mucosal immunology, eosinophilic esophagitis, and other intestinal inflammatory diseases. (20176262)
2010
28
Medical and nutrition management of eosinophilic esophagitis in children. (20413697)
2010
29
Esophageal dilation in eosinophilic esophagitis: safety and predictors of clinical response and complications. (20170913)
2010
30
Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis. (20568382)
2010
31
Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. (20682320)
2010
32
A systematic review of the risk of perforation during esophageal dilation for patients with eosinophilic esophagitis. (20238250)
2010
33
Esophageal dilation in eosinophilic esophagitis: effectiveness, safety, and impact on the underlying inflammation. (19935783)
2010
34
Diagnosis of eosinophilic esophagitis after fundoplication for 'refractory reflux': implications for preoperative evaluation. (19863640)
2010
35
Eosinophilic esophagitis due to profilin allergy. (19639743)
2009
36
The first Asian case report of eosinophilic esophagitis in an asymptomatic adult: what about a proton pump inhibitor trial? (19299228)
2009
37
Curious elements of esophageal foreign body impaction and eosinophilic esophagitis. (20567528)
2009
38
Eosinophilic esophagitis. (20043612)
2009
39
Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis. (19141355)
2009
40
Spontaneous circumferential esophageal dissection in a young man with eosinophilic esophagitis. (19752151)
2009
41
Eosinophilic esophagitis: from the case report to the evidence. (18717053)
2008
42
Epidemiology and etiology of eosinophilic esophagitis. (18061100)
2008
43
Histopathologic features of eosinophilic esophagitis. (18061102)
2008
44
Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses. (19079190)
2008
45
Basic pathogenesis of eosinophilic esophagitis. (18061107)
2008
46
Eosinophilic esophagitis and gastritis in Rubinstein-Taybi syndrome. (17414149)
2007
47
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. (16453027)
2006
48
Eosinophilic esophagitis. (16606552)
2006
49
A Japanese case of eosinophilic esophagitis. (16933010)
2006
50
Eosinophilic gastroenteritis with esophageal involvement. (870380)
1977

Genetic Variations for Eosinophilic Esophagitis

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Expression for genes affiliated with Eosinophilic Esophagitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilic Esophagitis

Search GEO for disease gene expression data for Eosinophilic Esophagitis.

Pathways for genes affiliated with Eosinophilic Esophagitis

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Sources:
52R&D Systems, 37NCBI BioSystems Database, 59Tocris Bioscience, 12EMD Millipore, 29KEGG, 51QIAGEN, 53Reactome
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Pathways related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3IL5, IL13
210.3VCAM1, STAT6
310.2CCL11, CCL26, IL5
410.2TSLP, STAT6, CCL11
5
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10.2IL5RA, IL5, IL13
6
Hide members
10.1CCL11, STAT6, IL13, IL5
7
Hide members
10.1HLA-DQA1, STAT6, IL13, IL5
8
Hide members
10.1CCR3, CCL26, CCL11, CCL24
9
Hide members
10.1CCL24, CCL11, CCL26, CCR3
10
Immune response CCR3 signaling in eosinophils
Hide members
10.1CCL24, CCL11, CCL26, CCR3
11
Hide members
10.0HLA-DQA1, IL5, IL5RA, VCAM1
129.8STAT6, IL13, IL15RA, IL5, IL5RA, TSLP
13
Hide members
9.8CCL24, CCL11, CCL26, STAT6, IL13, IL15RA
14
Hide members
9.8CCL24, CCL11, CCL26, CCR3, STAT6, PRG2
15
Hide members
9.7IL5, CCL11, HLA-DQA1, PRG2, RNASE3, IL13
16
Hide members
9.6CCL24, CCL11, CCL26, CCR3, IL13, IL15RA
17
Hide members
9.6CCL24, CCL26, CCR3, STAT6, PRG2, IL15RA
18
Hide members
9.6CCL24, CCL11, CCL26, CCR3, IL13, IL15RA
19
Hide members
9.5CCL24, CCL11, CCL26, CCR3, STAT6, IL13

Compounds for genes affiliated with Eosinophilic Esophagitis

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1pge24410.8CCL11
2rantes4410.7RNASE3, CCL11
3unicap4410.6CCL11, RNASE3, IL5
4mometasone furoate44 5911.6RNASE3, IL5, VCAM1
5lte44410.5CCL11, RNASE3, IL5
6beclomethasone dipropionate4410.5RNASE3, IL5, VCAM1
7hematoxylin4410.5IVL, PRG2
8salmeterol44 49 28 1113.5IL5, IL13, RNASE3, CCL11
9cetirizine44 28 11 2413.5CCL11, RNASE3, IL5
10sodium cromoglycate4410.5CCL11, RNASE3, IL5, VCAM1
11montelukast44 49 28 1113.5CCL11, RNASE3, IL13, IL5
12ltd44410.5IL5, IL13, RNASE3, CCR3
13pranlukast44 28 1112.5CCL11, RNASE3, IL5
144-ipp5910.5IL13, IL5, IL5RA
15praziquantel44 1111.5IL5, IL13, RNASE3
16git 275910.5IL13, IL5, IL5RA
17ketotifen44 1111.4CCL11, RNASE3, IL5
18salbutamol44 49 28 11 2414.4VCAM1, IL5, IL13, RNASE3, CCL11
19ltc44410.4CCL11, PRG2, RNASE3, IL13, IL5
20ccl344 2811.4CCL24, CCL11, CCL26, CCR3, IL13
21methacholine44 1111.4CCL11, PRG2, RNASE3, IL13, IL5
22pirfenidone44 5911.4IL5RA, IL5, IL13
23prednisolone44 28 1112.4CCL11, RNASE3, IL13, IL5, VCAM1
24fluticasone propionate44 49 59 1113.4CCL11, STAT6, RNASE3, IL13, IL5, VCAM1
25pgd24410.3CCL11, CCR3, PRG2, RNASE3, IL13, IL5
26as 10159 4411.3IL5RA, IL5, IL13
27budesonide44 49 1112.3CCL11, RNASE3, IL13, IL5, IL5RA, VCAM1
28fmlp4410.3CCL11, PRG2, RNASE3, IL13, IL5, VCAM1
29oxygen44 2411.3IVL, PRG2, CCR3, CCL26, CCL11
30tarc4410.3CCL24, CCL11, CCL26, CCR3, IL13, IL5
31heparin44 28 11 2413.2CCL11, CCR3, PRG2, RNASE3, IL13, VCAM1
32actinomycin d4410.2CCL24, CCL11, CCR3, STAT6, PRG2, IL13
33sb 20358044 5911.2CCL11, STAT6, IVL, MUC5AC, IL13, IL5
34leukotriene b444 59 2412.1CCL11, RNASE3, IL13, IL5
35superoxide44 2411.0CCL24, CCL11, CCL26, PRG2, IL5RA, VCAM1
36allergens4410.0TSLP, CCL11, STAT6, FLG, PRG2, IVL
37n acetylcysteine4410.0CCL11, STAT6, MUC5AC, RNASE3, VCAM1
38arginine4410.0HLA-DQA1, FLG, PRG2, RNASE3, IL13, IL5
39phosphatidylinositol449.9CCL11, STAT6, IVL, MUC5AC, IL13, VCAM1
40butyrate449.9CCL11, CCR3, IL5
41polysaccharide449.9VCAM1, IL13, RNASE3, MUC5AC, IVL
42cysteine449.9CCL26, CCR3, FLG, PRG2, IVL, MUC5AC
43steroid449.9CCL24, CCL11, STAT6, FLG, IVL, MUC5AC
44histamine44 28 2411.9CCL24, CCL11, CCR3, STAT6, PRG2, MUC5AC
45dexamethasone44 49 28 1112.8CCL11, CCR3, STAT6, IVL, MUC5AC, RNASE3
46nitric oxide44 11 2411.8CCL11, FLG, PRG2, MUC5AC, RNASE3, IL13
47adenylate449.8VCAM1, IL5, IL13, RNASE3, IVL, CCR3
48calcium44 49 11 2412.7CCL24, CCL11, CCL26, CCR3, STAT6, FLG
49retinoic acid44 2410.5PRG2, FLG, STAT6, CCR3, CCL11, IVL
50tyrosine449.5PRG2, FLG, STAT6, CCR3, CCL11, IVL

GO Terms for genes affiliated with Eosinophilic Esophagitis

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16Gene Ontology
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Cellular components related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056159.4TSLP, CCL11, CCL26, CCR3, IL13, IL15RA

Biological processes related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1mast cell chemotaxisGO:00255110.5CCR3, CCL11
2eosinophil chemotaxisGO:04824510.5CCR3, CCL11, CCL24
3positive regulation of Rac GTPase activityGO:03285510.4CCL26, CCL11, CCL24
4positive regulation of actin filament polymerizationGO:03083810.4CCL24, CCL11, CCL26
5positive regulation of endothelial cell proliferationGO:00193810.4CCL24, CCL11, CCL26, CCR3
6chronic inflammatory responseGO:00254410.3VCAM1, CCL11
7keratinocyte differentiationGO:03021610.3SPRR3, IVL, FLG
8ERK1 and ERK2 cascadeGO:07037110.3CCR3, CCL11
9chemotaxisGO:00693510.3CCL24, CCL11, CCL26, CCR3, RNASE2
10inflammatory responseGO:00695410.2CCL24, CCL11, CCL26, CCR3, IL13, IL5
11positive regulation of angiogenesisGO:04576610.2CCL24, CCL11, CCR3
12cytokine-mediated signaling pathwayGO:01922110.1VCAM1, IL5, IL15RA, HLA-DQA1
13immune responseGO:00695510.1IL5, IL13, PRG2, HLA-DQA1, CCL26, CCL11
14positive regulation of cell migrationGO:03033510.1CCL26, CCL11, CCL24
15cell adhesionGO:00715510.1CCL11, CCR3, MUC5AC, SIGLEC8, VCAM1
16RNA catabolic processGO:0064019.9RNASE2, RNASE3
17signal transductionGO:0071659.9CCL24, CCL11, CCL26, STAT6, IL13, IL15RA

Molecular functions related to Eosinophilic Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pancreatic ribonuclease activityGO:00452210.2RNASE2, RNASE3
2chemokine activityGO:00800910.1CCL26, CCL11, CCL24
3ribonuclease activityGO:0045409.9RNASE2, RNASE3

Products for genes affiliated with Eosinophilic Esophagitis

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  • Antibodies
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Sources for Eosinophilic Esophagitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet