MCID: ESN006
MIFTS: 48

Eosinophilic Meningitis malady

Neuronal diseases category

Summaries for Eosinophilic Meningitis

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34MalaCards
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MalaCards: Eosinophilic Meningitis is related to meningitis and angiostrongyliasis. An important gene associated with Eosinophilic Meningitis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Selected targets of GCR alpha and Syndecan-1-mediated signaling events. The compounds omalizumab and ovomucoid have been mentioned in the context of this disorder. Affiliated tissues include brain and endothelial, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Eosinophilic Meningitis

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9Disease Ontology, 63UMLS, 28ICD9CM, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

eosinophilic meningitis 9 63


External Ids:

Disease Ontology9 DOID:10361
SNOMED-CT59 25671008
ICD9CM28 322.1

Related Diseases for Eosinophilic Meningitis

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18GeneCards, 19GeneDecks
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Diseases related to Eosinophilic Meningitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis31.8MMP9
2angiostrongyliasis30.9MMP9
3sinusitis30.2IL5
4eosinophilia29.8CCL24, IL4, IL2, IL5, IL10, IL13
5meningoencephalitis10.4
6headache10.2
7eosinophilic fasciitis10.1IL5
8kimura disease10.1IL5
9eosinophilic esophagitis10.1IL5
10malaria10.1IL10
11intraocular lymphoma10.1IL10
12periapical granuloma10.1IL4
13keratoconjunctivitis10.1IL5, IL13
14filariasis10.1IL13, IL5
15helminthiasis10.1IL5, IL13
16eosinophilic pneumonia10.1IL5, IL13
17leprosy10.1IL2
18esophagitis10.1IL13, IL5
19mastocytosis10.1IL5, IL13
20bronchiolitis10.1IL5, IL13
21egg allergy10.1IL5, IL4
22intrinsic asthma10.1IL4, IL5
23allergic bronchopulmonary aspergillosis10.1IL4, IL5
24omenn syndrome10.1IL5, IL4
25alcoholic hepatitis10.1IL10, HGF
26selective iga deficiency disease10.0IL4, IL10
27visceral leishmaniasis10.0IL4, IL10
28conjunctivochalasis10.0PLAU, MMP9
29bullous pemphigoid10.0IL5, IL13, PLAU
30abdominal aortic aneurysm10.0MMP9, PLAU
31type 1 diabetes mellitus10.0IL10, IL4
32allergic conjunctivitis10.0IL4, IL5, IL13
33asthma10.0IL4, IL5, IL13
34pulmonary eosinophilia10.0IL4, IL5, IL13
35allergic rhinitis10.0IL13, IL5, IL4
36food allergy10.0IL4, IL5, IL13
37atopic dermatitis10.0IL13, IL4
38relapsing-remitting multiple sclerosis10.0MMP9, IL10
39rhinitis10.0IL4, IL5, IL13
40dermatitis10.0IL13, IL5, IL4
41proliferative diabetic retinopathy10.0MMP9, HGF
42bone carcinoma10.0MMP9, PLAU
43dirofilariasis10.0
44toxocariasis10.0
45rocky mountain spotted fever10.0
46gnathomiasis10.0
47coccidioidomycosis10.0
48conjugate gaze palsy10.0
49congenital toxoplasmosis10.0
50encephalitis10.0

Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to eosinophilic meningitis

Symptoms for Eosinophilic Meningitis

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Drugs & Therapeutics for Eosinophilic Meningitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Eosinophilic Meningitis

Drug clinical trials:

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Search NIH Clinical Center for Eosinophilic Meningitis

Search CenterWatch for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

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Anatomical Context for Eosinophilic Meningitis

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34MalaCards
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MalaCards organs/tissues related to Eosinophilic Meningitis:

34
Brain, Endothelial

Animal Models for Eosinophilic Meningitis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Eosinophilic Meningitis:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9MMP9, IL2, IL5, IL10, PLAU
2MP:00030127.9IL4, IL2, IL10, IL13, HGF
3MP:00053857.7HGF, PLAU, IL10, IL2, MMP9
4MP:00053707.6IL4, IL2, IL5, IL10, PLAU, HGF
5MP:00053797.5IL4, IL2, IL10, IL13, PLAU
6MP:00053817.2MMP9, IL4, IL2, IL5, IL10, IL13
7MP:00053897.2MMP9, IL4, IL2, IL5, IL10, IL13
8MP:00053847.1MMP9, IL4, IL2, IL10, IL13, PLAU
9MP:00053767.0MMP9, IL4, IL2, IL5, IL10, IL13
10MP:00107686.8MMP9, IL4, IL2, IL10, IL13, PLAU
11MP:00053786.8MMP9, IL4, IL2, IL5, IL10, IL13
12MP:00053886.7PLAU, MMP9, CCL24, IL4, IL2, IL5
13MP:00053876.7MMP9, CCL24, IL4, IL2, IL5, IL10
14MP:00053976.3MMP9, CCL24, IL4, IL2, IL5, IL10

Publications for Eosinophilic Meningitis

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53PubMed
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Articles related to Eosinophilic Meningitis:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an adolescent with mental retardation and pica disorder. (23445744)
2013
2
Eosinophilic meningitis. (23829911)
2013
3
Eosinophilic meningitis in a 10-year old nigerian boy: a case report. (24381722)
2013
4
Eosinophilic meningitis in a previously healthy 13-year-old child. (23328824)
2013
5
Medical management of eosinophilic meningitis following bovine graft duraplasty for Chiari malformation Type I repair: case report. (23909615)
2013
6
The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected with Angiostrongylus cantonensis. (22152396)
2013
7
Corticosteroids for parasitic eosinophilic meningitis. (23076953)
2012
8
A case report on eosinophilic meningitis caused by Angiostrongylus cantonensis. (21897764)
2011
9
Sacral myeloradiculitis (Elsberg syndrome) secondary to eosinophilic meningitis caused by Angiostrongylus cantonensis. (21811516)
2009
10
Comparison of prednisolone plus albendazole with prednisolone alone for treatment of patients with eosinophilic meningitis. (19706911)
2009
11
Eosinophilic meningitis - an immunophenotyping recording of a very rare clinical entity - brief Report. (19649744)
2009
12
Cluster of eosinophilic meningitis attributable to Angiostrongylus cantonensis infection in French policemen troop returning from the Pacific Islands. (18760253)
2008
13
A case of eosinophilic meningitis in Germany. (18481034)
2008
14
Helminthic eosinophilic meningitis: emerging zoonotic diseases in the South. (19283982)
2008
15
Detection of circulating antibody of Parastrongylus cantonensis in sera with eosinophilic meningitis by dot-blot ELISA. (18839849)
2008
16
Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. (17703945)
2007
17
Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. (17360889)
2007
18
Multi-immunodot for rapid differential diagnosis of eosinophilic meningitis due to parasitic infections. (16923267)
2006
19
Chinese herbal medicine Yin-Chen-Extract as an adjunct to anthelmintic albendazole used against Angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis. (16968941)
2006
20
Eosinophilic meningitis after implantation of a rifampin and minocycline-impregnated ventriculostomy catheter in a child. Case report. (16509482)
2006
21
Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis. (15810979)
2005
22
Multilevel intramedullary spinal neurocysticercosis with eosinophilic meningitis. (15148157)
2004
23
Elevation of plasminogen activators in cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. (15542096)
2004
24
Combined treatment with interleukin-12 and mebendazole lessens the severity of experimental eosinophilic meningitis caused by Angiostrongylus cantonensis in ICR mice. (12819081)
2003
25
Enzootic Angiostrongylus cantonensis in rats and snails after an outbreak of human eosinophilic meningitis, Jamaica. (11927033)
2002
26
Angiostrongylus cantonensis eosinophilic meningitis. (10460929)
1999
27
Eosinophilic meningitis in a newborn with group B streptococcal infection. (8265296)
1993
28
Eosinophilic meningitis. (8356350)
1993
29
Eosinophilic meningitis in two cows. (8117811)
1993
30
Eosinophilic meningitis beyond the Pacific Basin: the global dispersal of a peridomestic zoonosis caused by Angiostrongylus cantonensis, the nematode lungworm of rats. (1738873)
1992
31
Eosinophilic meningitis in Thailand. Clinical and epidemiological characteristics of 162 patients with myeloencephalitis probably caused by Gnathostoma spinigerum. (2376755)
1990
32
Eosinophilic meningitis--a case report and literature review. (2133754)
1990
33
Eosinophilic meningitis and radiculomyelitis in Thailand, caused by CNS invasion of Gnathostoma spinigerum and Angiostrongylus cantonensis. (3351533)
1988
34
Differential diagnosis of eosinophilic meningitis. (15463120)
1988
35
Eosinophilic meningitis preceding meningeal relapse in a child with acute lymphoblastic leukemia: abnormal nucleotide content of eosinophils. (3152930)
1987
36
Leptomeningeal carcinomatosis presenting as eosinophilic meningitis. (3456181)
1986
37
The chronic and severe forms of eosinophilic meningitis. (6591910)
1984
38
Eosinophilic meningitis. (6636755)
1983
39
Eosinophilic meningitis and hydrocephalus in an infant. (7092618)
1982
40
Eosinophilic meningitis in Hodgkin disease. (7195513)
1981
41
Eosinophilic meningitis. (294917)
1979
42
Eosinophilic meningitis in Hodgkin's disease. (517907)
1979
43
Nidality of eosinophilic meningitis with special reference to Angiostrongylus cantonensis. (632707)
1978
44
Clinical observations on eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis on Taiwan. (1259085)
1976
45
Case of ocular angiostrongyliasis associated with eosinophilic meningitis. (5102754)
1971
46
Lesions of the brain in eosinophilic meningitis. (5410412)
1970
47
Eosinophilic meningitis in Thailand. Epidemiologic studies of 484 typical cases and the etiologic role of Angiostrongylus cantonensis. (5531201)
1970
48
Studies on eosinophilic meningitis. V. Molluscan hosts of Angiostrongylus cantonensis on Pacific Islands. (5777734)
1969
49
Eosinophilic meningitis in Hodgkin's disease. (5348868)
1969
50
Studies on eosinophilic meningitis. IV. Experimental infection of fresh-water and marine fish with Angiostrongylus cantonensis. (6025084)
1967

Variations for Eosinophilic Meningitis

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Expression for genes affiliated with Eosinophilic Meningitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilic Meningitis

Search GEO for disease gene expression data for Eosinophilic Meningitis.

Pathways for genes affiliated with Eosinophilic Meningitis

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Sources:
51PathCards, 13EMD Millipore, 39NCBI BioSystems Database, 55R&D Systems, 61Thomson Reuters, 31KEGG, 62Tocris Bioscience, 56Reactome, 54QIAGEN, 5Cell Signaling Technology
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Pathways related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL5, IL4
29.6HGF, MMP9
39.5PLAU, MMP9
49.5PLAU, MMP9
59.5PLAU, MMP9
69.5MMP9, PLAU
79.5IL2, IL13
8
Show member pathways
IL2 signaling events mediated by STAT539
9.4IL2, IL4
99.4IL13, IL5, IL4
10
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.4IL4, IL5, IL13
119.3HGF, IL10
12
Show member pathways
9.2IL13, IL5, IL2
13
Show member pathways
9.2IL13, IL5, IL2
149.2HGF, PLAU, MMP9
159.2HGF, PLAU, MMP9
16
Show member pathways
9.2HGF, IL5, IL2
17
Show member pathways
9.2IL2, IL5, HGF
189.1IL4, IL2, IL5
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
9.1IL5, IL2, IL4
20
Show member pathways
9.1IL4, IL2, IL13
21
Show member pathways
IL27-mediated signaling events39
9.0IL10, IL2
22
Show member pathways
9.0IL2, IL10
239.0HGF, IL2, IL4
24
Show member pathways
9.0HGF, IL2, IL4
258.9IL4, IL5, IL10
268.9IL2, IL4, MMP9
278.7IL4, IL2, IL5, IL13
288.6IL4, IL2, IL10
29
Show member pathways
8.5HGF, PLAU, IL2, MMP9
30
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.5IL10, IL2, MMP9
31
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.3IL4, IL2, IL5, IL10
327.9IL4, IL2, IL5, IL10, IL13
337.9IL13, IL10, IL5, IL2, IL4
347.9IL4, IL2, IL5, IL10, IL13
35
Show member pathways
7.9IL4, IL2, IL5, IL10, IL13
36
Show member pathways
7.9IL4, IL2, IL5, IL10, IL13
37
Show member pathways
Type III interferon signaling39
7.9IL4, IL2, IL5, IL10, IL13
38
Show member pathways
7.0CCL24, IL4, IL2, IL5, IL10, IL13
39
Show member pathways
7.0CCL24, HGF, IL13, IL10, IL5, IL2
40
Show member pathways
7.0CCL24, IL4, IL2, IL5, IL10, IL13
41
Show member pathways
7.0CCL24, IL4, IL2, IL5, IL10, IL13
42
Show member pathways
7.0IL13, IL10, IL5, IL2, IL4, CCL24

Compounds for genes affiliated with Eosinophilic Meningitis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 186)
idCompoundScoreTop Affiliating Genes
1omalizumab46 1210.6IL13, IL5, IL4
2ovomucoid469.4IL13, IL4, IL5
3fluticasone propionate46 52 62 1212.1IL13, MMP9, IL5, IL4
4salmeterol46 52 30 1212.1IL4, IL2, IL13, IL5
5praziquantel46 129.9IL4, IL13, IL5, IL10
6montelukast46 52 30 1211.9IL13, IL10, IL5, IL4
7bleomycin46 129.8IL13, HGF, MMP9, IL4, IL5
8mip 1alpha468.8IL4, IL10, IL13, PLAU
9rolipram46 62 3010.8IL4, IL10, IL13, IL5
10doxycycline46 129.8MMP9, IL5, IL13, PLAU
11as 10146 629.7IL2, IL5, IL10, IL13
12interferon gamma468.7IL10, IL2, IL4
13alpha-galactosylceramide468.6IL2, IL10, IL4, IL13
14acetaldehyde30 46 2510.6HGF, PLAU, IL10, IL4
15con a468.6IL2, IL10, IL4, IL5
16polyinosinic-polycytidylic acid468.5IL4, IL2, IL5, IL10
17ivig468.5IL10, IL5, IL4, MMP9
18tarc468.4CCL24, IL4, IL5, IL10, IL13
19thalidomide46 52 62 1211.4IL10, IL2, IL5, IL13, HGF
20glatiramer acetate46 129.4IL4, IL13, IL10, IL5, IL2
21il-12468.3IL13, IL10, IL5, IL2, IL4
22gm-csf46 309.3IL10, IL5, IL2, IL4, IL13
23prednisolone46 30 1210.3IL2, HGF, IL5, IL10, IL13
24tgf beta1468.3PLAU, IL13, IL10, MMP9, HGF
25indomethacin46 30 62 1211.3HGF, IL13, IL5, PLAU, IL2, IL4
26il 10468.3IL5, IL13, IL10, IL2, IL4
27pentoxifylline46 129.3IL2, IL4, IL13, IL10
28adenylate468.3HGF, IL13, IL4, IL5, PLAU, MMP9
29ccl346 309.3IL13, MMP9, CCL24, IL10
30allergens468.2IL13, IL10, IL5, IL4
31ionomycin468.2IL13, IL2, IL10, IL5, IL4
32ribavirin46 52 1210.2MMP9, IL10, IL4, IL2
33dmso468.2IL2, HGF, IL5, IL10, PLAU
34herbimycin a46 629.2MMP9, IL4, IL2, HGF, PLAU, IL5
35calcitriol46 62 25 1211.1IL10, IL2, IL13, PLAU, IL4
36tacrolimus46 52 129.9IL2, HGF, IL13, IL10, IL5, IL4
37paraffin467.9HGF, PLAU, IL10, IL4, MMP9, IL5
38cyclophosphamide46 52 129.7IL13, HGF, MMP9, IL4, IL2, IL10
39sb 20358046 628.7IL10, IL13, PLAU, HGF, IL4, MMP9
40ly294002467.7PLAU, MMP9, HGF, IL13, IL10, IL5
41actinomycin d467.6IL4, PLAU, HGF, MMP9, CCL24, IL2
42hydrocortisone46 3 62 1210.6IL13, IL4, IL2, IL5, IL10, PLAU
43thymidine46 258.5IL13, PLAU, IL10, HGF, IL4, IL2
44cyclosporin a46 30 629.4HGF, IL13, IL10, IL5, IL2, IL4
45dexamethasone46 52 30 1210.4MMP9, IL4, IL2, IL5, IL10, IL13
46rantes467.3CCL24, IL4, IL2, IL5, IL13, IL10
47histamine46 30 259.1IL4, CCL24, HGF, IL2, IL5, IL10
48pge2467.1PLAU, IL13, HGF, IL10, IL5, IL2
49cycloheximide467.0IL2, MMP9, IL4, HGF, PLAU, IL13
50vegf467.0IL13, MMP9, IL4, IL10, HGF, IL2

GO Terms for genes affiliated with Eosinophilic Meningitis

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17Gene Ontology
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Cellular components related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9IL2, IL5, IL13, PLAU, HGF, MMP9
2extracellular spaceGO:0056155.8HGF, MMP9, CCL24, IL4, IL2, IL5

Biological processes related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:01015510.0IL13, IL4
2positive regulation of immunoglobulin secretionGO:0510249.8IL2, IL5
3positive regulation of isotype switching to IgG isotypesGO:0483049.7IL4, IL2
4positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.5IL2, IL4
5regulation of isotype switchingGO:0451919.5IL10, IL4
6type 2 immune responseGO:0420929.5IL10, IL4
7positive regulation of activated T cell proliferationGO:0421049.5IL2, IL4
8positive regulation of MHC class II biosynthetic processGO:0453489.4IL4, IL10
9negative regulation of nitric oxide biosynthetic processGO:0450199.4IL10, IL4
10extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.3IL2, IL4
11chemotaxisGO:0069359.3CCL24, IL4, PLAU
12proteolysisGO:0065089.3MMP9, PLAU, HGF
13B cell differentiationGO:0301839.2IL10, IL4
14positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL10, IL5, IL4
15positive regulation of B cell proliferationGO:0308909.1IL13, IL5, IL2, IL4
16positive regulation of inflammatory responseGO:0507299.0IL2, CCL24
17inflammatory responseGO:0069548.8CCL24, IL5, IL10, IL13
18immune responseGO:0069558.5CCL24, IL4, IL2, IL5, IL13
19cell-cell signalingGO:0072678.5CCL24, IL2, IL10, IL13
20negative regulation of apoptotic processGO:0430668.4HGF, IL10, IL2, IL4
21positive regulation of transcription from RNA polymerase II promoterGO:0459448.2IL4, IL2, IL10, HGF

Molecular functions related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051257.9IL2, IL5, IL10, IL13, IL4
2growth factor activityGO:0080837.6HGF, IL10, IL5, IL2, IL4

Products for genes affiliated with Eosinophilic Meningitis

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Sources for Eosinophilic Meningitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet