MCID: ESN006
MIFTS: 45

Eosinophilic Meningitis malady

Summaries for Eosinophilic Meningitis

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32MalaCards
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MalaCards: Eosinophilic Meningitis is related to meningitis and angiostrongyliasis. An important gene associated with Eosinophilic Meningitis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Osteopontin Signaling and Osteopontin-mediated events. The compounds hydrocortisone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include brain and endothelial, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Classifications for Eosinophilic Meningitis

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8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

eosinophilic meningitis 8 60


External Ids:

Disease Ontology8 DOID:10361
SNOMED-CT56 25671008
ICD9CM27 322.1

Related Diseases for Eosinophilic Meningitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to eosinophilic meningitis

Clinical Features for Eosinophilic Meningitis

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Drugs & Therapeutics for Eosinophilic Meningitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Eosinophilic Meningitis

Drug clinical trials:

Search ClinicalTrials for Eosinophilic Meningitis

Search NIH Clinical Center for Eosinophilic Meningitis

Search CenterWatch for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

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Anatomical Context for Eosinophilic Meningitis

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32MalaCards
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MalaCards organs/tissues related to Eosinophilic Meningitis:

32
Brain, Endothelial

Animal Models for Eosinophilic Meningitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eosinophilic Meningitis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.6IL2, IL4
2MP:00053889.5PLAU, MMP9, CCL24
3MP:00053899.3IL13, MMP9, PLAU
4MP:00020068.9IL10, IL5, IL2, MMP9
5MP:00053768.6IL13, IL5, IL4, IL2
6MP:00053707.7HGF, IL10, IL5, IL4, IL2, PLAU
7MP:00053817.6IL13, IL10, IL5, IL4, IL2, MMP9
8MP:00053877.1CCL24, IL13, IL10, IL5, IL4, IL2
9MP:00053846.9HGF, IL13, IL10, IL4, IL2, MMP9
10MP:00053786.7HGF, IL13, IL10, IL5, IL4, IL2
11MP:00107686.6HGF, IL13, IL10, IL4, IL2, MMP9
12MP:00053976.3HGF, CCL24, IL13, IL10, IL5, IL4

Publications for Eosinophilic Meningitis

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50PubMed
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Articles related to Eosinophilic Meningitis:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Guest Editor's message: Eosinophilic meningitis caused by Angiostrongylus cantonensis, the rat lungworm: biology, distribution, epidemiology, detection, diagnosis, treatment, and management. (23901370)
2013
2
Dexamethasone downregulated the expression of CSF 14-3-3I^ protein in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection. (24361722)
2013
3
First case of neurognathostomiasis in Taiwan-A Thai laborer presenting with eosinophilic meningitis and intracranial hemorrhage. (23969044)
2013
4
Clinical aspects of eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis, the rat lungworm. (23901382)
2013
5
Severe eosinophilic meningitis owing to Angiostrongylus cantonensis in young Jamaican children: case report and literature review. (24199629)
2013
6
Eosinophilic meningitis without peripheral eosinophilia. (22414697)
2012
7
Efficacy of combined treatment with albendazole and baicalein against eosinophilic meningitis induced by Angiostrongylus cantonensis in mice. (20587113)
2011
8
Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis. (20584616)
2010
9
Eosinophilic meningitis due to Angiostrongylus cantonensis in Germany. (19674273)
2009
10
A case of eosinophilic meningitis in Germany. (18481034)
2008
11
Detection of circulating antibody of Parastrongylus cantonensis in sera with eosinophilic meningitis by dot-blot ELISA. (18839849)
2008
12
Eosinophilic meningitis associated with angiostrongyliasis: clinical features, laboratory investigations and specific diagnostic IgG and IgG subclass antibodies in cerebrospinal fluid. (17539242)
2007
13
Albendazole therapy for eosinophilic meningitis caused by Angiostrongylus cantonensis. (17177056)
2007
14
Chinese herbal medicine Yin-Chen-Extract as an adjunct to anthelmintic albendazole used against Angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis. (16968941)
2006
15
Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis. (15810979)
2005
16
Induction of matrix metalloproteinase-9 in murine eosinophilic meningitis caused by Angiostrongylus cantonensis. (15509425)
2004
17
Eosinophilic meningitis caused by Angiostrongylus cantonensis: a case report and literature review. (15569579)
2004
18
Outbreak of eosinophilic meningitis associated with drinking raw vegetable juice in southern Taiwan. (15306715)
2004
19
Eosinophilic meningitis due to Angiostrongylus cantonensis in Switzerland. (15057577)
2004
20
Eosinophilic meningitis in a neonate. (12043718)
2002
21
Travel warning: Eosinophilic meningitis caused by rat lungworm. (12000253)
2002
22
Eosinophilic meningitis caused by Angiostrongylus cantonensis: report of 17 cases. (11498063)
2001
23
Eosinophilic meningitis due to Angiostrongylus cantonensis in a returned traveler: case report and review of the literature. (11568860)
2001
24
Eosinophilic meningitis associated with coccidioidomycosis. (8460518)
1993
25
Eosinophilic meningitis in Thailand. Clinical and epidemiological characteristics of 162 patients with myeloencephalitis probably caused by Gnathostoma spinigerum. (2376755)
1990
26
Eosinophilic meningitis: cause of a chronic pain syndrome. (2246659)
1990
27
Eosinophilic meningitis associated with ciprofloxacin. (2816976)
1989
28
Eosinophilic meningitis and radiculomyelitis in Thailand, caused by CNS invasion of Gnathostoma spinigerum and Angiostrongylus cantonensis. (3351533)
1988
29
Differential diagnosis of eosinophilic meningitis. (15463120)
1988
30
Escargots and eosinophilic meningitis. (2899728)
1988
31
Angiostrongylus (Parastrongylus) eosinophilic meningitis. (3060943)
1988
32
Eosinophilic meningitis preceding meningeal relapse in a child with acute lymphoblastic leukemia: abnormal nucleotide content of eosinophils. (3152930)
1987
33
Leptomeningeal carcinomatosis presenting as eosinophilic meningitis. (3456181)
1986
34
Toxocariasis and eosinophilic meningitis. (3933615)
1985
35
The chronic and severe forms of eosinophilic meningitis. (6591910)
1984
36
Basophilic-eosinophilic meningitis in an undifferentiated myeloproliferative disorder. (6848784)
1983
37
Eosinophilic meningitis and hydrocephalus in an infant. (7092618)
1982
38
Eosinophilic meningitis: a suspected case of angiostrongylosis found in Shizuoka Prefecture, Honshu, Japan. (434313)
1979
39
Nidality of eosinophilic meningitis with special reference to Angiostrongylus cantonensis. (632707)
1978
40
Eosinophilic meningitis in Tahiti: clinical study of 54 patients. (283329)
1978
41
Eosinophilic meningitis complicating Hodgkin's disease. A report of a case and review of the literature. (69484)
1977
42
Epidemiologic studies of eosinophilic meningitis in southern Taiwan. (1155688)
1975
43
Angiostrongyliasis cantonensis (eosinophilic meningitis, Alicata's disease). (1095293)
1975
44
Case of ocular angiostrongyliasis associated with eosinophilic meningitis. (5102754)
1971
45
Studies on eosinophilic meningitis. V. Molluscan hosts of Angiostrongylus cantonensis on Pacific Islands. (5777734)
1969
46
Eosinophilic meningitis among children in Hawaii. (6016803)
1967
47
Studies on eosinophilic meningitis. 3. Epidemiologic and clinical observations on Pacific islands and the possible etiologic role of Angiostrongylus cantonensis. (6066788)
1967
48
Studies on eosinophilic meningitis. 2. Experimental infection of shrimp and crabs with Angiostrongylus cantonensis. (5944728)
1966
49
STUDIES ON EOSINOPHILIC MENINGITIS. I. OBSERVATIONS ON THE GEOGRAPHIC DISTRIBUTION OF ANGIOSTRONGYLUS CANTONENSIS IN THE PACIFIC AREA AND ITS PREVALENCE IN WILD RATS. (14246081)
1965
50
Observations on an outbreak of eosinophilic meningitis on Tahiti, French Polynesia. (13743342)
1961

Genetic Variations for Eosinophilic Meningitis

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Expression for genes affiliated with Eosinophilic Meningitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilic Meningitis

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Pathways for genes affiliated with Eosinophilic Meningitis

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37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 4Cell Signaling Technology, 59Tocris Bioscience, 51QIAGEN, 53Reactome, 12EMD Millipore
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Pathways related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PLAU, MMP9
29.8PLAU, MMP9
39.8PLAU, MMP9
4
Hide members
9.5IL5, IL13
5
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9.5IL2, IL10
69.4IL2, IL13
79.3IL5, IL4, IL2
8
Hide members
9.3IL2, IL4, IL5
99.3HGF, MMP9
109.2IL4, IL2, MMP9
119.2IL10, IL5, IL4
12
Hide members
9.1IL10, IL2, MMP9
139.1IL13, IL5, IL4
149.1IL2, IL4, IL10
15
Hide members
9.1IL2, IL5, IL13
16
Hide members
9.1IL13, IL5, IL2
178.9PLAU, MMP9, HGF
18
Hide members
8.9HGF, MMP9, PLAU
198.9HGF, MMP9, PLAU
20
Hide members
8.9IL2, IL5, HGF
21
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8.8IL5, CCL24, HGF
22
Hide members
8.8IL2, IL4, IL5, IL10
23
Hide members
8.7IL2, IL4, IL5, IL13
248.7IL2, IL4, IL5, IL13
25
Hide members
8.6IL13, IL10, IL5, IL4
26
Hide members
8.2HGF, CCL24, IL13, IL5
27
Hide members
8.2HGF, CCL24, IL13, IL5
288.1IL13, IL10, IL5, IL4, IL2
298.1IL13, IL10, IL5, IL4, IL2
308.1IL2, IL4, IL5, IL10, IL13
31
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7.7HGF, CCL24, IL13, IL5, IL2
32
Hide members
6.8HGF, CCL24, IL13, IL10, IL5, IL4

Compounds for genes affiliated with Eosinophilic Meningitis

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44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.6PLAU
2gm-csf44 2811.4IL10
3aprotinin44 1111.1PLAU
4cycloheximide4410.1HGF
5rantes4410.1IL2, IL4
6pge2449.7PLAU, IL2, MMP9
7cyclophosphamide44 49 1111.6HGF, IL2
8omalizumab44 1110.4IL13, IL5, IL4
9indomethacin44 59 28 1112.4IL5, HGF, PLAU
10c-d4t449.4IL2, IL4, IL5
11interferon gamma449.3IL4, IL2, IL10
12con a449.1IL5, IL2, IL10, IL4
13polyinosinic-polycytidylic acid449.1IL10, IL5, IL4, IL2
14fluticasone propionate44 49 59 1112.1MMP9, IL5, IL13, IL4
15prednisolone44 28 1111.1IL13, IL5, HGF
16salmeterol44 49 28 1112.1IL13, IL2, IL4, IL5
17praziquantel44 1110.0IL4, IL5, IL10, IL13
18mip 1alpha449.0PLAU, IL10, IL13, IL4
19montelukast44 49 28 1112.0IL5, IL13, IL4, IL10
20ribavirin44 49 1110.9IL2, IL4, IL10, MMP9
21gabexate mesilate448.9PLAU, IL10, MMP9
22doxycycline44 119.9IL13, MMP9, PLAU, IL5
23as 10159 449.9IL13, IL5, IL10, IL2
24alpha-galactosylceramide448.9IL2, IL4, IL10, IL13
25dexamethasone44 49 28 1111.7HGF, IL5, IL13, MMP9
26acetaldehyde44 28 2410.6HGF, IL4, PLAU, IL10
27pentoxifylline44 119.6IL13, IL2, IL4, IL10
28allergens448.6IL10, IL4, IL5, IL13
29glatiramer acetate44 119.6IL10, IL13, IL2, IL4, IL5
30il-12448.6IL13, IL5, IL10, IL4, IL2
31ccl344 289.6CCL24, IL10, IL13, MMP9
32il 10448.6IL4, IL13, IL10, IL5, IL2
33tarc448.5IL10, CCL24, IL5, IL4, IL13
34ionomycin448.4IL10, IL5, IL4, IL2, IL13
35pdtc448.4IL4, HGF, PLAU, MMP9
36calcitriol44 59 11 2411.4IL10, IL13, PLAU, IL4, IL2
37bleomycin44 119.3HGF, MMP9, IL4, IL5, IL13
38dmso448.3IL10, HGF, IL2, PLAU, IL5
39herbimycin a44 599.2IL5, HGF, IL4, IL2, PLAU, MMP9
40tgf beta1448.1PLAU, HGF, IL10, MMP9, IL13
41thalidomide44 49 59 1111.1IL5, IL10, IL13, HGF, IL2
42paraffin448.0IL4, IL5, HGF, IL10, PLAU, MMP9
43adenylate447.8IL13, IL5, HGF, MMP9, PLAU, IL4
44tacrolimus44 49 119.7IL10, IL13, IL5, IL2, HGF, IL4
45sb 20358044 598.5IL5, PLAU, MMP9, IL4, HGF, IL13
46ly294002447.5PLAU, MMP9, IL5, IL10, IL13, HGF
47thymidine44 248.4HGF, IL10, IL4, IL13, IL5, PLAU
48actinomycin d447.3IL13, HGF, CCL24, IL4, MMP9, PLAU
49vegf447.0IL10, IL2, PLAU, HGF, IL13, IL5
50histamine44 28 248.9CCL24, IL13, HGF, IL10, IL5, IL4

GO Terms for genes affiliated with Eosinophilic Meningitis

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16Gene Ontology
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Cellular components related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5IL13, IL5, IL2, MMP9, PLAU, HGF
2extracellular spaceGO:0056155.8PLAU, HGF, CCL24, IL13, IL10, IL5

Biological processes related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:0510249.8IL2, IL5
2regulation of isotype switchingGO:0451919.8IL4, IL10
3type 2 immune responseGO:0420929.8IL4, IL10
4positive regulation of isotype switching to IgG isotypesGO:0483049.8IL2, IL4
5positive regulation of MHC class II biosynthetic processGO:0453489.7IL4, IL10
6regulation of proton transportGO:0101559.7IL13, IL4
7negative regulation of nitric oxide biosynthetic processGO:0450199.6IL4, IL10
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.5IL2, IL4
9positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL10, IL5, IL4
10chemotaxisGO:0069359.3CCL24, IL4, PLAU
11positive regulation of activated T cell proliferationGO:0421049.3IL4, IL2
12positive regulation of B cell proliferationGO:0308909.0IL2, IL4, IL5, IL13
13inflammatory responseGO:0069548.7IL5, IL10, IL13, CCL24
14cell-cell signalingGO:0072678.6CCL24, IL13, IL10, IL2
15immune responseGO:0069558.4CCL24, IL13, IL5, IL4, IL2
16negative regulation of apoptotic processGO:0430668.3HGF, IL10, IL4, IL2
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.3IL2, IL4, IL10, HGF

Molecular functions related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.1IL10, IL5, IL4, IL2, IL13
2growth factor activityGO:0080837.6IL2, IL4, IL5, IL10, HGF

Products for genes affiliated with Eosinophilic Meningitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Eosinophilic Meningitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet