MCID: ESN006
MIFTS: 43

Eosinophilic Meningitis malady

Summaries for Eosinophilic Meningitis

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33MalaCards
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MalaCards: Eosinophilic Meningitis is related to angiostrongyliasis and sinusitis. An important gene associated with Eosinophilic Meningitis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Osteopontin Signaling and Osteopontin-mediated events. The compounds hydrocortisone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include brain, b lymphoblasts and endothelial, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Classifications for Eosinophilic Meningitis

Sources:
8Disease Ontology, 61UMLS, 27ICD9CM, 57SNOMED-CT
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Aliases & Descriptions:

eosinophilic meningitis 8 61


External Ids:

Disease Ontology8 DOID:10361
SNOMED-CT57 25671008
ICD9CM27 322.1

Related Diseases for Eosinophilic Meningitis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to eosinophilic meningitis

Clinical Features for Eosinophilic Meningitis

Drugs & Therapeutics for Eosinophilic Meningitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Eosinophilic Meningitis

Drug clinical trials:

Search ClinicalTrials for Eosinophilic Meningitis

Search NIH Clinical Center for Eosinophilic Meningitis

Search CenterWatch for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

Anatomical Context for Eosinophilic Meningitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Eosinophilic Meningitis:

33
Brain, B lymphoblasts, Endothelial

Animal Models for Eosinophilic Meningitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Eosinophilic Meningitis

Sources:
51PubMed
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Articles related to Eosinophilic Meningitis:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Eosinophilic meningitis in a previously healthy 13-year-old child. (23328824)
2013
2
Eosinophilic meningitis secondary to intravenous vancomycin. (22842500)
2013
3
An 8-week Brain MRI Follow-up Analysis of Rat Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection. (24207053)
2013
4
An interesting case of eosinophilic meningitis. (23730662)
2013
5
The first case of Angiostrongylus cantonensis eosinophilic meningitis diagnosed in the city of SALo Paulo, Brazil. (23563769)
2013
6
Curcumin alleviates eosinophilic meningitis through reduction of eosinophil count following albendazole treatment against Angiostrongylus cantonensis in mice. (22053741)
2012
7
Clinical manifestations of eosinophilic meningitis caused by Angiostrongylus cantonensis: 18 years' experience in a medical center in southern Taiwan. (21524976)
2011
8
Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. (21856305)
2011
9
Drug target in eosinophilic meningitis caused by Angiostrongylus cantonensis. (20701570)
2010
10
Lead poisoning in calves associated with eosinophilic meningitis. (21262614)
2010
11
Wider range for parasites that cause eosinophilic meningitis. (19780663)
2009
12
Cluster of eosinophilic meningitis attributable to Angiostrongylus cantonensis infection in French policemen troop returning from the Pacific Islands. (18760253)
2008
13
A case of eosinophilic meningitis in Germany. (18481034)
2008
14
Helminthic eosinophilic meningitis: emerging zoonotic diseases in the South. (19283982)
2008
15
Detection of circulating antibody of Parastrongylus cantonensis in sera with eosinophilic meningitis by dot-blot ELISA. (18839849)
2008
16
Eosinophilic meningitis due to Angiostrongylus cantonensis in a Belgian traveller. (18342273)
2008
17
Biochemical and pathological evaluation of albendazole/thalidomide co-therapy against eosinophilic meningitis or meningoencephalitis induced by Angiostrongylus cantonensis. (17298991)
2007
18
Eosinophilic meningitis in a returned traveler from Santo Domingo: case report and review. (17995537)
2007
19
Eosinophilic meningitis caused by Angiostrongylus cantonensis after ingestion of raw frogs. (17297055)
2007
20
Eosinophilic meningitis after implantation of a rifampin and minocycline-impregnated ventriculostomy catheter in a child. Case report. (16509482)
2006
21
Ultrastructural localization of matrix metalloproteinase-9 in eosinophils from the cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. (15667715)
2004
22
Outbreak of eosinophilic meningitis associated with drinking raw vegetable juice in southern Taiwan. (15306715)
2004
23
Combined treatment with interleukin-12 and mebendazole lessens the severity of experimental eosinophilic meningitis caused by Angiostrongylus cantonensis in ICR mice. (12819081)
2003
24
Eosinophilic meningitis caused by Angiostrongylus cantonensis associated with eating raw snails: correlation of brain magnetic resonance imaging scans with clinical findings. (12685630)
2003
25
Enzootic Angiostrongylus cantonensis in rats and snails after an outbreak of human eosinophilic meningitis, Jamaica. (11927033)
2002
26
An outbreak of eosinophilic meningitis caused by Angiostrongylus cantonensis in travelers returning from the Caribbean. (11870244)
2002
27
Travel warning: Eosinophilic meningitis caused by rat lungworm. (12000253)
2002
28
Eosinophilic meningitis caused by Angiostrongylus cantonensis: report of 17 cases. (11498063)
2001
29
Immunodiagnosis of human eosinophilic meningitis using an antigen of Angiostrongylus cantonensis L5 with molecular weight 204 kD. (10708002)
2000
30
Eosinophilic meningitis. An unusual cause of headache. (10431425)
1999
31
Eosinophilic meningitis in a newborn with group B streptococcal infection. (8265296)
1993
32
Congenital toxoplasmosis presenting with eosinophilic meningitis. (8483631)
1993
33
Eosinophilic meningitis due to Angiostrongylus cantonensis. (8123100)
1993
34
Eosinophilic meningitis associated with coccidioidomycosis. (8460518)
1993
35
Eosinophilic meningitis in Thailand. Clinical and epidemiological characteristics of 162 patients with myeloencephalitis probably caused by Gnathostoma spinigerum. (2376755)
1990
36
Eosinophilic meningitis associated with ciprofloxacin. (2816976)
1989
37
Leptomeningeal carcinomatosis presenting as eosinophilic meningitis. (3456181)
1986
38
Toxocariasis and eosinophilic meningitis. (3933615)
1985
39
The chronic and severe forms of eosinophilic meningitis. (6591910)
1984
40
Eosinophilic meningitis in Hodgkin's disease. Report of a case and review of the literature. (6338855)
1983
41
ELISA for the detection of angiostrongylus cantonensis antibodies in patients with eosinophilic meningitis. (7051339)
1982
42
Eosinophils in cerebrospinal fluid: criteria for eosinophilic meningitis. (7251346)
1981
43
Eosinophilic meningitis following myelography. (7373812)
1980
44
Eosinophilic meningitis. (294917)
1979
45
Eosinophilic meningitis in Hodgkin's disease. (517907)
1979
46
Eosinophilic meningitis in Tahiti: clinical study of 54 patients. (283329)
1978
47
Letter: Eosinophilic meningitis and lymphomatous meningitis. (1172922)
1975
48
Lesions of the brain in eosinophilic meningitis. (5410412)
1970
49
Eosinophilic meningitis among children in Hawaii. (6016803)
1967
50
STUDIES ON EOSINOPHILIC MENINGITIS. I. OBSERVATIONS ON THE GEOGRAPHIC DISTRIBUTION OF ANGIOSTRONGYLUS CANTONENSIS IN THE PACIFIC AREA AND ITS PREVALENCE IN WILD RATS. (14246081)
1965

Genetic Variations for Eosinophilic Meningitis

Expression for genes affiliated with Eosinophilic Meningitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilic Meningitis

Search GEO for disease gene expression data for Eosinophilic Meningitis.

Pathways for genes affiliated with Eosinophilic Meningitis

Sources:
38NCBI BioSystems Database, 30KEGG, 53R&D Systems, 4Cell Signaling Technology, 60Tocris Bioscience, 52QIAGEN, 54Reactome, 12EMD Millipore
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Pathways related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PLAU, MMP9
29.8PLAU, MMP9
39.8PLAU, MMP9
4
Hide members
9.5IL5, IL13
5
Hide members
9.5IL2, IL10
69.4IL2, IL13
79.3IL5, IL4, IL2
8
Hide members
9.3IL2, IL4, IL5
99.3HGF, MMP9
109.2IL4, IL2, MMP9
119.2IL10, IL5, IL4
12
Hide members
9.1IL10, IL2, MMP9
139.1IL13, IL5, IL4
149.1IL2, IL4, IL10
15
Hide members
9.1IL2, IL5, IL13
16
Hide members
9.1IL13, IL5, IL2
178.9PLAU, MMP9, HGF
18
Hide members
8.9HGF, MMP9, PLAU
198.9HGF, MMP9, PLAU
20
Hide members
8.9IL2, IL5, HGF
21
Hide members
8.8IL5, CCL24, HGF
22
Hide members
8.8IL2, IL4, IL5, IL10
23
Hide members
8.7IL2, IL4, IL5, IL13
248.7IL2, IL4, IL5, IL13
25
Hide members
8.6IL13, IL10, IL5, IL4
26
Hide members
8.2HGF, CCL24, IL13, IL5
27
Hide members
8.2HGF, CCL24, IL13, IL5
288.1IL13, IL10, IL5, IL4, IL2
298.1IL13, IL10, IL5, IL4, IL2
308.1IL2, IL4, IL5, IL10, IL13
31
Hide members
7.7HGF, CCL24, IL13, IL5, IL2
32
Hide members
6.8HGF, CCL24, IL13, IL10, IL5, IL4

Compounds for genes affiliated with Eosinophilic Meningitis

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB
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Compounds related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1hydrocortisone45 2 60 1113.6PLAU
2gm-csf45 2911.4IL10
3aprotinin45 1111.1PLAU
4cycloheximide4510.1HGF
5rantes4510.1IL2, IL4
6pge2459.7PLAU, IL2, MMP9
7cyclophosphamide45 50 1111.6HGF, IL2
8omalizumab45 1110.4IL13, IL5, IL4
9indomethacin45 60 29 1112.4IL5, HGF, PLAU
10c-d4t459.4IL2, IL4, IL5
11interferon gamma459.3IL4, IL2, IL10
12con a459.1IL5, IL2, IL10, IL4
13polyinosinic-polycytidylic acid459.1IL10, IL5, IL4, IL2
14fluticasone propionate45 50 60 1112.1MMP9, IL5, IL13, IL4
15prednisolone45 29 1111.1IL13, IL5, HGF
16salmeterol45 50 29 1112.1IL13, IL2, IL4, IL5
17praziquantel45 1110.0IL4, IL5, IL10, IL13
18mip 1alpha459.0PLAU, IL10, IL13, IL4
19montelukast45 50 29 1112.0IL5, IL13, IL4, IL10
20ribavirin45 50 1110.9IL2, IL4, IL10, MMP9
21gabexate mesilate458.9PLAU, IL10, MMP9
22doxycycline45 119.9IL13, MMP9, PLAU, IL5
23as 10160 459.9IL13, IL5, IL10, IL2
24alpha-galactosylceramide458.9IL2, IL4, IL10, IL13
25dexamethasone45 50 29 1111.7HGF, IL5, IL13, MMP9
26acetaldehyde45 29 2410.6HGF, IL4, PLAU, IL10
27pentoxifylline45 119.6IL13, IL2, IL4, IL10
28allergens458.6IL10, IL4, IL5, IL13
29glatiramer acetate45 119.6IL10, IL13, IL2, IL4, IL5
30il-12458.6IL13, IL5, IL10, IL4, IL2
31ccl345 299.6CCL24, IL10, IL13, MMP9
32il 10458.6IL4, IL13, IL10, IL5, IL2
33tarc458.5IL10, CCL24, IL5, IL4, IL13
34ionomycin458.4IL10, IL5, IL4, IL2, IL13
35pdtc458.4IL4, HGF, PLAU, MMP9
36calcitriol45 60 11 2411.4IL10, IL13, PLAU, IL4, IL2
37bleomycin45 119.3HGF, MMP9, IL4, IL5, IL13
38dmso458.3IL10, HGF, IL2, PLAU, IL5
39herbimycin a45 609.2IL5, HGF, IL4, IL2, PLAU, MMP9
40tgf beta1458.1PLAU, HGF, IL10, MMP9, IL13
41thalidomide45 50 60 1111.1IL5, IL10, IL13, HGF, IL2
42paraffin458.0IL4, IL5, HGF, IL10, PLAU, MMP9
43adenylate457.8IL13, IL5, HGF, MMP9, PLAU, IL4
44tacrolimus45 50 119.7IL10, IL13, IL5, IL2, HGF, IL4
45sb 20358045 608.5IL5, PLAU, MMP9, IL4, HGF, IL13
46ly294002457.5PLAU, MMP9, IL5, IL10, IL13, HGF
47thymidine45 248.4HGF, IL10, IL4, IL13, IL5, PLAU
48actinomycin d457.3IL13, HGF, CCL24, IL4, MMP9, PLAU
49vegf457.0IL10, IL2, PLAU, HGF, IL13, IL5
50histamine45 29 248.9CCL24, IL13, HGF, IL10, IL5, IL4

GO Terms for genes affiliated with Eosinophilic Meningitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5HGF, IL13, IL5, IL2, MMP9, PLAU
2extracellular spaceGO:0056155.8HGF, CCL24, IL13, IL10, IL5, IL4

Biological processes related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:0510249.8IL2, IL5
2regulation of isotype switchingGO:0451919.8IL10, IL4
3type 2 immune responseGO:0420929.8IL10, IL4
4positive regulation of isotype switching to IgG isotypesGO:0483049.8IL4, IL2
5positive regulation of MHC class II biosynthetic processGO:0453489.7IL4, IL10
6regulation of proton transportGO:0101559.7IL4, IL13
7negative regulation of nitric oxide biosynthetic processGO:0450199.6IL10, IL4
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.5IL4, IL2
9positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL4, IL10, IL5
10chemotaxisGO:0069359.3PLAU, CCL24, IL4
11positive regulation of activated T cell proliferationGO:0421049.3IL4, IL2
12positive regulation of B cell proliferationGO:0308909.0IL2, IL13, IL5, IL4
13inflammatory responseGO:0069548.7IL5, IL10, IL13, CCL24
14cell-cell signalingGO:0072678.6CCL24, IL13, IL10, IL2
15immune responseGO:0069558.4IL5, IL4, IL2, CCL24, IL13
16negative regulation of apoptotic processGO:0430668.3HGF, IL4, IL2, IL10
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.3HGF, IL10, IL4, IL2

Molecular functions related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.1IL13, IL10, IL5, IL4, IL2
2growth factor activityGO:0080837.6HGF, IL10, IL5, IL4, IL2

Products for genes affiliated with Eosinophilic Meningitis

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Sources for Eosinophilic Meningitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet