MCID: ESN006
MIFTS: 45

Eosinophilic Meningitis malady

Summaries for Eosinophilic Meningitis

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32MalaCards
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MalaCards: Eosinophilic Meningitis is related to meningitis and angiostrongyliasis. An important gene associated with Eosinophilic Meningitis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Osteopontin Signaling and Osteopontin-mediated events. The compounds hydrocortisone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include brain and endothelial, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Classifications for Eosinophilic Meningitis

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8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

eosinophilic meningitis 8 60


External Ids:

Disease Ontology8 DOID:10361
SNOMED-CT56 25671008
ICD9CM27 322.1

Related Diseases for Eosinophilic Meningitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to eosinophilic meningitis

Clinical Features for Eosinophilic Meningitis

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Drugs & Therapeutics for Eosinophilic Meningitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Eosinophilic Meningitis

Drug clinical trials:

Search ClinicalTrials for Eosinophilic Meningitis

Search NIH Clinical Center for Eosinophilic Meningitis

Search CenterWatch for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

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Anatomical Context for Eosinophilic Meningitis

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32MalaCards
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MalaCards organs/tissues related to Eosinophilic Meningitis:

32
Brain, Endothelial

Animal Models for Eosinophilic Meningitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eosinophilic Meningitis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.6IL2, IL4
2MP:00053889.5PLAU, MMP9, CCL24
3MP:00053899.3IL13, MMP9, PLAU
4MP:00020068.9IL10, IL5, IL2, MMP9
5MP:00053768.6IL13, IL5, IL4, IL2
6MP:00053707.7HGF, IL10, IL5, IL4, IL2, PLAU
7MP:00053817.6IL13, IL10, IL5, IL4, IL2, MMP9
8MP:00053877.1CCL24, IL13, IL10, IL5, IL4, IL2
9MP:00053846.9HGF, IL13, IL10, IL4, IL2, MMP9
10MP:00053786.7HGF, IL13, IL10, IL5, IL4, IL2
11MP:00107686.6HGF, IL13, IL10, IL4, IL2, MMP9
12MP:00053976.3HGF, CCL24, IL13, IL10, IL5, IL4

Publications for Eosinophilic Meningitis

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50PubMed
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Articles related to Eosinophilic Meningitis:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an adolescent with mental retardation and pica disorder. (23445744)
2013
2
Eosinophilic meningitis in a previously healthy 13-year-old child. (23328824)
2013
3
An interesting case of eosinophilic meningitis. (23730662)
2013
4
A severe case of Angiostrongylus eosinophilic meningitis with encephalitis and neurologic sequelae in Hawa'i. (23901383)
2013
5
The first case of Angiostrongylus cantonensis eosinophilic meningitis diagnosed in the city of SALo Paulo, Brazil. (23563769)
2013
6
Corticosteroids for parasitic eosinophilic meningitis. (23076953)
2012
7
Curcumin alleviates eosinophilic meningitis through reduction of eosinophil count following albendazole treatment against Angiostrongylus cantonensis in mice. (22053741)
2012
8
A case report on eosinophilic meningitis caused by Angiostrongylus cantonensis. (21897764)
2011
9
Clinical manifestations of eosinophilic meningitis caused by Angiostrongylus cantonensis: 18 years' experience in a medical center in southern Taiwan. (21524976)
2011
10
Eosinophilic meningitis risk associated with raw Ampullarium canaliculatus snails consumption. (21527185)
2011
11
Specificity of immunoblotting analyses in eosinophilic meningitis. (21894378)
2011
12
Comparison of prednisolone plus albendazole with prednisolone alone for treatment of patients with eosinophilic meningitis. (19706911)
2009
13
Recognizing and reducing the risks of helminthic eosinophilic meningitis in travelers: differential diagnosis, disease management, prevention, and control. (19674268)
2009
14
Eosinophilic meningitis due to Angiostrongylus and Gnathostoma species. (19123863)
2009
15
Eosinophilic meningitis and an ocular worm in a patient from Kerala, south India. (21687288)
2009
16
Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. (17360889)
2007
17
Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. (17381860)
2007
18
Eosinophilic meningitis after implantation of a rifampin and minocycline-impregnated ventriculostomy catheter in a child. Case report. (16509482)
2006
19
Eosinophilic meningitis? Consider angiostrongyliasis. (16895272)
2006
20
Treatment of eosinophilic meningitis with a combination of prednisolone and mebendazole. (16760531)
2006
21
Angiostrongylus cantonensis: efficacy of albendazole-dexamethasone co-therapy against infection-induced plasminogen activators and eosinophilic meningitis. (16410005)
2006
22
A letter regarding a case of eosinophilic meningitis. (15892262)
2005
23
A case of eosinophilic meningitis following monitor lizard meat consumption, exacerbated by anthelminthics. (16114775)
2005
24
Multilevel intramedullary spinal neurocysticercosis with eosinophilic meningitis. (15148157)
2004
25
Elevation of plasminogen activators in cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. (15542096)
2004
26
Ultrastructural localization of matrix metalloproteinase-9 in eosinophils from the cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. (15667715)
2004
27
Eosinophilic meningitis caused by Angiostrongylus cantonensis associated with eating raw snails: correlation of brain magnetic resonance imaging scans with clinical findings. (12685630)
2003
28
Enzootic Angiostrongylus cantonensis in rats and snails after an outbreak of human eosinophilic meningitis, Jamaica. (11927033)
2002
29
Eosinophilic meningitis. An unusual cause of headache. (10431425)
1999
30
Horizontal conjugate gaze palsy in eosinophilic meningitis. (10774676)
1999
31
Eosinophilic meningitis/angiostrongyliasis from eating aquaculture-raised snails: a case report. (9844300)
1998
32
Eosinophilic meningitis in a newborn with group B streptococcal infection. (8265296)
1993
33
Eosinophilic meningitis in two cows. (8117811)
1993
34
Bilateral facial nerve paresis in eosinophilic meningitis. (1940709)
1991
35
Detection of antibodies to Angiostrongylus cantonensis in serum and cerebrospinal fluid of patients with eosinophilic meningitis. (2040566)
1991
36
Eosinophilic meningitis caused by Angiostrongylus cantonensis. (2367166)
1990
37
Eosinophilic meningitis. (3347155)
1988
38
Eosinophilic meningitis caused by Rocky Mountain spotted fever. (3946444)
1986
39
Eosinophilic meningitis. (6541319)
1984
40
Eosinophilic meningitis in Hodgkin's disease. Report of a case and review of the literature. (6338855)
1983
41
Studies on eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis in Japan. (6424245)
1983
42
Eosinophilic meningitis in Hodgkin disease. (7195513)
1981
43
Eosinophilic meningitis in a case of disseminated glioblastoma. (7458725)
1981
44
Eosinophilic meningitis in Thailand. Clinical studies of 484 typical cases probably caused by Angiostrongylus cantonensis. (1200257)
1975
45
Eosinophilic meningitis (angiostrongylosis): a probable case. (1143147)
1975
46
Eosinophilic meningitis in Thailand. Epidemiologic studies of 484 typical cases and the etiologic role of Angiostrongylus cantonensis. (5531201)
1970
47
Eosinophilic meningitis in Hodgkin's disease. (5348868)
1969
48
Five cases of eosinophilic meningitis in Sarawak. (4244149)
1969
49
Eosinophilic meningitis: report of two unusual cases. (5247142)
1968
50
EOSINOPHILIC MENINGITIS. (14077077)
1963

Genetic Variations for Eosinophilic Meningitis

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Expression for genes affiliated with Eosinophilic Meningitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilic Meningitis

Search GEO for disease gene expression data for Eosinophilic Meningitis.

Pathways for genes affiliated with Eosinophilic Meningitis

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Sources:
37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 4Cell Signaling Technology, 59Tocris Bioscience, 51QIAGEN, 53Reactome, 12EMD Millipore
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Pathways related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PLAU, MMP9
29.8PLAU, MMP9
39.8PLAU, MMP9
4
Hide members
9.5IL5, IL13
5
Hide members
9.5IL2, IL10
69.4IL2, IL13
79.3IL5, IL4, IL2
8
Hide members
9.3IL2, IL4, IL5
99.3HGF, MMP9
109.2IL4, IL2, MMP9
119.2IL10, IL5, IL4
12
Hide members
9.1IL10, IL2, MMP9
139.1IL13, IL5, IL4
149.1IL2, IL4, IL10
15
Hide members
9.1IL2, IL5, IL13
16
Hide members
9.1IL13, IL5, IL2
178.9PLAU, MMP9, HGF
18
Hide members
8.9HGF, MMP9, PLAU
198.9HGF, MMP9, PLAU
20
Hide members
8.9IL2, IL5, HGF
21
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8.8IL5, CCL24, HGF
22
Hide members
8.8IL2, IL4, IL5, IL10
23
Hide members
8.7IL2, IL4, IL5, IL13
248.7IL2, IL4, IL5, IL13
25
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8.6IL13, IL10, IL5, IL4
26
Hide members
8.2HGF, CCL24, IL13, IL5
27
Hide members
8.2HGF, CCL24, IL13, IL5
288.1IL13, IL10, IL5, IL4, IL2
298.1IL13, IL10, IL5, IL4, IL2
308.1IL2, IL4, IL5, IL10, IL13
31
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7.7HGF, CCL24, IL13, IL5, IL2
32
Hide members
6.8HGF, CCL24, IL13, IL10, IL5, IL4

Compounds for genes affiliated with Eosinophilic Meningitis

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.6PLAU
2gm-csf44 2811.4IL10
3aprotinin44 1111.1PLAU
4cycloheximide4410.1HGF
5rantes4410.1IL2, IL4
6pge2449.7PLAU, IL2, MMP9
7cyclophosphamide44 49 1111.6HGF, IL2
8omalizumab44 1110.4IL13, IL5, IL4
9indomethacin44 59 28 1112.4IL5, HGF, PLAU
10c-d4t449.4IL2, IL4, IL5
11interferon gamma449.3IL4, IL2, IL10
12con a449.1IL5, IL2, IL10, IL4
13polyinosinic-polycytidylic acid449.1IL10, IL5, IL4, IL2
14fluticasone propionate44 49 59 1112.1MMP9, IL5, IL13, IL4
15prednisolone44 28 1111.1IL13, IL5, HGF
16salmeterol44 49 28 1112.1IL13, IL2, IL4, IL5
17praziquantel44 1110.0IL4, IL5, IL10, IL13
18mip 1alpha449.0PLAU, IL10, IL13, IL4
19montelukast44 49 28 1112.0IL5, IL13, IL4, IL10
20ribavirin44 49 1110.9IL2, IL4, IL10, MMP9
21gabexate mesilate448.9PLAU, IL10, MMP9
22doxycycline44 119.9IL13, MMP9, PLAU, IL5
23as 10159 449.9IL13, IL5, IL10, IL2
24alpha-galactosylceramide448.9IL2, IL4, IL10, IL13
25dexamethasone44 49 28 1111.7HGF, IL5, IL13, MMP9
26acetaldehyde44 28 2410.6HGF, IL4, PLAU, IL10
27pentoxifylline44 119.6IL13, IL2, IL4, IL10
28allergens448.6IL10, IL4, IL5, IL13
29glatiramer acetate44 119.6IL10, IL13, IL2, IL4, IL5
30il-12448.6IL13, IL5, IL10, IL4, IL2
31ccl344 289.6CCL24, IL10, IL13, MMP9
32il 10448.6IL4, IL13, IL10, IL5, IL2
33tarc448.5IL10, CCL24, IL5, IL4, IL13
34ionomycin448.4IL10, IL5, IL4, IL2, IL13
35pdtc448.4IL4, HGF, PLAU, MMP9
36calcitriol44 59 11 2411.4IL10, IL13, PLAU, IL4, IL2
37bleomycin44 119.3HGF, MMP9, IL4, IL5, IL13
38dmso448.3IL10, HGF, IL2, PLAU, IL5
39herbimycin a44 599.2IL5, HGF, IL4, IL2, PLAU, MMP9
40tgf beta1448.1PLAU, HGF, IL10, MMP9, IL13
41thalidomide44 49 59 1111.1IL5, IL10, IL13, HGF, IL2
42paraffin448.0IL4, IL5, HGF, IL10, PLAU, MMP9
43adenylate447.8IL13, IL5, HGF, MMP9, PLAU, IL4
44tacrolimus44 49 119.7IL10, IL13, IL5, IL2, HGF, IL4
45sb 20358044 598.5IL5, PLAU, MMP9, IL4, HGF, IL13
46ly294002447.5PLAU, MMP9, IL5, IL10, IL13, HGF
47thymidine44 248.4HGF, IL10, IL4, IL13, IL5, PLAU
48actinomycin d447.3IL13, HGF, CCL24, IL4, MMP9, PLAU
49vegf447.0IL10, IL2, PLAU, HGF, IL13, IL5
50histamine44 28 248.9CCL24, IL13, HGF, IL10, IL5, IL4

GO Terms for genes affiliated with Eosinophilic Meningitis

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16Gene Ontology
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Cellular components related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5IL13, IL5, IL2, MMP9, PLAU, HGF
2extracellular spaceGO:0056155.8PLAU, HGF, CCL24, IL13, IL10, IL5

Biological processes related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:0510249.8IL2, IL5
2regulation of isotype switchingGO:0451919.8IL4, IL10
3type 2 immune responseGO:0420929.8IL4, IL10
4positive regulation of isotype switching to IgG isotypesGO:0483049.8IL2, IL4
5positive regulation of MHC class II biosynthetic processGO:0453489.7IL4, IL10
6regulation of proton transportGO:0101559.7IL13, IL4
7negative regulation of nitric oxide biosynthetic processGO:0450199.6IL4, IL10
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.5IL2, IL4
9positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL10, IL5, IL4
10chemotaxisGO:0069359.3CCL24, IL4, PLAU
11positive regulation of activated T cell proliferationGO:0421049.3IL4, IL2
12positive regulation of B cell proliferationGO:0308909.0IL2, IL4, IL5, IL13
13inflammatory responseGO:0069548.7IL5, IL10, IL13, CCL24
14cell-cell signalingGO:0072678.6CCL24, IL13, IL10, IL2
15immune responseGO:0069558.4CCL24, IL13, IL5, IL4, IL2
16negative regulation of apoptotic processGO:0430668.3HGF, IL10, IL4, IL2
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.3IL2, IL4, IL10, HGF

Molecular functions related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.1IL10, IL5, IL4, IL2, IL13
2growth factor activityGO:0080837.6IL2, IL4, IL5, IL10, HGF

Products for genes affiliated with Eosinophilic Meningitis

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  • Antibodies
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Sources for Eosinophilic Meningitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet