MCID: ESN006
MIFTS: 38

Eosinophilic Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Eosinophilic Meningitis

MalaCards integrated aliases for Eosinophilic Meningitis:

Name: Eosinophilic Meningitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:10361
ICD9CM 34 322.1
SNOMED-CT 64 25671008
UMLS 69 C0154652

Summaries for Eosinophilic Meningitis

MalaCards based summary : Eosinophilic Meningitis is related to hypereosinophilic syndrome and allergic hypersensitivity disease. An important gene associated with Eosinophilic Meningitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain and endothelial, and related phenotypes are hematopoietic system and immune system

Related Diseases for Eosinophilic Meningitis

Diseases related to Eosinophilic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 29.0 CCL11 IL13 IL5
2 allergic hypersensitivity disease 28.6 CCL11 IL13 IL4 IL5
3 angiostrongyliasis 28.3 CCL11 IL13 IL4 IL5 MMP9 PLAU
4 gnathomiasis 11.0
5 meningitis 10.8
6 cough variant asthma 10.3 IL4 IL5
7 chromoblastomycosis 10.3 IL4 MMP9
8 egg allergy 10.3 IL4 IL5
9 trichinosis 10.3 IL4 IL5
10 atopic keratoconjunctivitis 10.3 IL4 IL5
11 non-suppurative otitis media 10.3 IL4 IL5
12 intrinsic asthma 10.3 IL4 IL5
13 pemphigoid gestationis 10.3 CCL11 IL5
14 cercarial dermatitis 10.3 IL4 IL5
15 toxic oil syndrome 10.3 IL4 IL5
16 blepharoconjunctivitis 10.3 CCL11 IL4
17 corneal ulcer 10.3 CCL11 MMP9
18 primary amebic meningoencephalitis 10.3 IL4 IL5
19 eosinophilic gastroenteritis 10.3 CCL11 IL5
20 chronic eosinophilic pneumonia 10.3 CCL11 IL5
21 papillary conjunctivitis 10.3 CCL11 IL4
22 giant papillary conjunctivitis 10.3 CCL11 IL4
23 allergic bronchopulmonary aspergillosis 10.2 IL4 IL5
24 immunoglobulin a deficiency 1 10.2 CD40LG IL4
25 milk allergy 10.2 IL4 IL5
26 parasitic ichthyosporea infectious disease 10.2 CD40LG IL4
27 congenital hypogammaglobulinemia 10.2 CD40LG IL4
28 rhinosporidiosis 10.2 CD40LG IL4
29 periodontosis 10.2 CD40LG MMP9
30 intratubular embryonal carcinoma 10.2 MMP9 PLAU
31 immunodeficiency with hyper-igm, type 1 10.2 CD40LG IL4
32 buruli ulcer 10.2 CD40LG IL4
33 pustulosis palmaris et plantaris 10.2 CD40LG IL5
34 japanese spotted fever 10.2 CCL11 CD40LG
35 primary systemic mycosis 10.2 CD40LG IL4
36 norwegian scabies 10.2 CD40LG IL5
37 paracoccidioidomycosis 10.2 IL4 IL5
38 coccidiosis 10.2 CD40LG IL4
39 lichen disease 10.1 CD40LG IL4
40 cryptosporidiosis 10.1 CCL11 CD40LG
41 pelvic inflammatory disease 10.1 CD40LG MMP9
42 scleritis 10.1 IL4 IL5 MMP9
43 granulomatous hepatitis 10.1 CD40LG IL4
44 churg-strauss syndrome 10.1 CD40LG IL5
45 carrion's disease 10.1 CCL11 CD40LG
46 extrinsic cardiomyopathy 10.1 CD40LG IL4
47 opportunistic mycosis 10.1 CD40LG IL4
48 blepharitis 10.1 CCL11 IL4 MMP9
49 cytokine deficiency 10.1 IL13 IL5
50 echinococcosis 10.1 CD40LG IL5

Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to Eosinophilic Meningitis

Symptoms & Phenotypes for Eosinophilic Meningitis

MGI Mouse Phenotypes related to Eosinophilic Meningitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.87 CCL11 CD40LG IL13 IL4 IL5 MMP9
2 immune system MP:0005387 9.8 CCL11 CD40LG IL13 IL4 IL5 MMP9
3 digestive/alimentary MP:0005381 9.77 IL13 IL4 IL5 MMP9 PLAU
4 integument MP:0010771 9.55 CD40LG IL13 IL4 MMP9 PLAU
5 reproductive system MP:0005389 9.43 CD40LG IL13 IL4 IL5 MMP9 PLAU
6 respiratory system MP:0005388 9.1 CCL11 IL13 IL4 IL5 MMP9 PLAU

Drugs & Therapeutics for Eosinophilic Meningitis

Drugs for Eosinophilic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Not yet recruiting NCT03378882

Search NIH Clinical Center for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

Anatomical Context for Eosinophilic Meningitis

MalaCards organs/tissues related to Eosinophilic Meningitis:

38
Brain, Endothelial

Publications for Eosinophilic Meningitis

Articles related to Eosinophilic Meningitis:

(show top 50) (show all 226)
# Title Authors Year
1
A Child With Intermittent Headaches and Eosinophilic Meningitis. ( 29438532 )
2018
2
Angiostrongylus cantonensis Is an Important Cause of Eosinophilic Meningitis in Southern Vietnam. ( 28158507 )
2017
3
Angiostrongylus cantonensis Eosinophilic Meningitis in an Infant, Tennessee, USA. ( 28930003 )
2017
4
Closing the Brief Case: Angiostrongylus cantonensis Eosinophilic Meningitis in a Returned Traveler. ( 28947512 )
2017
5
Angiostrongylus cantonensis DNA in Cerebrospinal Fluid of Persons with Eosinophilic Meningitis, Laos. ( 29148389 )
2017
6
The Brief Case: Angiostrongylus cantonensis Eosinophilic Meningitis in a Returned Traveler. ( 28947508 )
2017
7
Eosinophilic Meningitis Due to Infection With Paragonimus kellicotti. ( 28158416 )
2017
8
Autochthonous Case of Eosinophilic Meningitis Caused by Angiostrongylus cantonensis, France, 2016. ( 28518042 )
2017
9
Eosinophilic Meningitis Caused by Angiostrongylus cantonensis. ( 28704038 )
2017
10
An epidemiological study of A. cantonensis in Jamaica subsequent to an outbreak of human cases of eosinophilic meningitis in 2000. ( 27350332 )
2016
11
Eosinophilic meningitis caused by Angiostrongylus cantonensis mimicking embolic stroke. ( 27185606 )
2016
12
Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection. ( 27278827 )
2016
13
Eosinophilic meningitis triggered by implanted Gliadel wafers: case report. ( 27285546 )
2016
14
Cryptococcal eosinophilic meningitis in a patient with sarcoidosis. ( 26682840 )
2015
15
Evaluation of dot immunogold filtration assay (DIGFA) for rapid serodiagnosis of eosinophilic meningitis due to Angio-strongylus cantonensis (Nematoda: Metastrongyloidea). ( 25801261 )
2015
16
Fibronectin changes in eosinophilic meningitis with blood-CSF barrier disruption. ( 25660199 )
2015
17
Corticosteroids for parasitic eosinophilic meningitis. ( 25687750 )
2015
18
Dexamethasone inhibits brain apoptosis in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 25890054 )
2015
19
Real-Time Polymerase Chain Reaction Detection of Angiostrongylus cantonensis DNA in Cerebrospinal Fluid from Patients with Eosinophilic Meningitis. ( 26526920 )
2015
20
Draft genome of neurotropic nematode parasite Angiostrongylus cantonensis, causative agent of human eosinophilic meningitis. ( 25910624 )
2015
21
Eosinophilic meningitis: a case series and review of literature of Angiostrongylus cantonensis and Gnathostoma spinigerum. ( 25560024 )
2015
22
Eosinophilic meningitis due to Angiostrongylus cantonensis with confirmed finding of intrathecal parasite. ( 24676451 )
2014
23
Unusual Larva in the CSF and Unique MRI Findings in a Case of Eosinophilic Meningitis. ( 25806134 )
2014
24
Expect the unexpected: a case of isolated eosinophilic meningitis in toxocariasis. ( 25535488 )
2014
25
MicroRNA expressions associated with eosinophilic meningitis caused by Angiostrongylus cantonensis infection in a mouse model. ( 24682888 )
2014
26
14-3-3I^ protein expression in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 24555778 )
2014
27
Eosinophilic Meningitis After Bovine Dural Graft Placement in a 5-Year-Old Male. ( 24803627 )
2014
28
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. ( 24586232 )
2014
29
Eosinophilic meningitis caused by Angiostrongylus cantonensis - a neglected disease with escalating importance. ( 25776582 )
2014
30
Acute eosinophilic meningitis and orbital inflammation from presumed angiostrongyliasis. ( 24862785 )
2014
31
Eosinophilic meningitis caused by Angiostrongylus cantonensis: an emergent disease in Brazil. ( 25075779 )
2014
32
Angiostrongylus cantonensis eosinophilic meningitis: a clinical study of 42 consecutive cases in French Polynesia. ( 24583335 )
2014
33
A rare case of Ibuprofen-induced eosinophilic meningitis in a 13-year-old girl. ( 24596473 )
2014
34
Eosinophilic meningitis: what's the "diff"? ( 24060328 )
2014
35
Eosinophilic meningitis in a 10-year old nigerian boy: a case report. ( 24381722 )
2013
36
A severe case of Angiostrongylus eosinophilic meningitis with encephalitis and neurologic sequelae in Hawa'i. ( 23901383 )
2013
37
Clinical aspects of eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis, the rat lungworm. ( 23901382 )
2013
38
Eosinophilic meningitis caused by primary angiitis of the central nervous system. ( 23774554 )
2013
39
Eosinophilic meningitis. ( 23829911 )
2013
40
The first case of Angiostrongylus cantonensis eosinophilic meningitis diagnosed in the city of SALo Paulo, Brazil. ( 23563769 )
2013
41
Severe eosinophilic meningitis owing to Angiostrongylus cantonensis in young Jamaican children: case report and literature review. ( 24199629 )
2013
42
An interesting case of eosinophilic meningitis. ( 23730662 )
2013
43
An 8-week Brain MRI Follow-up Analysis of Rat Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection. ( 24207053 )
2013
44
Clinical manifestations of Eosinophilic meningitis due to infection with Angiostrongylus cantonensis in children. ( 24516281 )
2013
45
Medical management of eosinophilic meningitis following bovine graft duraplasty for Chiari malformation Type I repair: case report. ( 23909615 )
2013
46
Genetic diversity of the rat lungworm, Angiostrongylus cantonensis, the major cause of eosinophilic meningitis. ( 23901375 )
2013
47
Guest Editor's message: Eosinophilic meningitis caused by Angiostrongylus cantonensis, the rat lungworm: biology, distribution, epidemiology, detection, diagnosis, treatment, and management. ( 23901370 )
2013
48
Eosinophilic meningitis in a previously healthy 13-year-old child. ( 23328824 )
2013
49
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an adolescent with mental retardation and pica disorder. ( 23445744 )
2013
50
Molecular diagnosis of eosinophilic meningitis due to Angiostrongylus cantonensis (Nematoda: Metastrongyloidea) by polymerase chain reaction-DNA sequencing of cerebrospinal fluids of patients. ( 23440126 )
2013

Variations for Eosinophilic Meningitis

Expression for Eosinophilic Meningitis

Search GEO for disease gene expression data for Eosinophilic Meningitis.

Pathways for Eosinophilic Meningitis

Pathways related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCL11 CD40LG IL13 IL4 IL5 MMP9
2
Show member pathways
13.18 CCL11 CD40LG IL13 IL4 IL5 YWHAB
3
Show member pathways
13.07 CCL11 CD40LG IL13 IL4 IL5
4
Show member pathways
13.06 CCL11 CD40LG IL13 IL4 IL5 MMP9
5
Show member pathways
12.66 CCL11 CD40LG IL13 IL4 IL5
6 12.63 IL13 IL4 IL5 MMP9
7
Show member pathways
12.37 IL13 IL4 IL5
8
Show member pathways
12.24 IL13 IL5 YWHAB
9
Show member pathways
12.23 CD40LG IL4 IL5
10
Show member pathways
12.19 CCL11 IL4 YWHAB
11
Show member pathways
12.17 IL13 IL4 IL5
12
Show member pathways
11.99 CCL11 IL13 IL4 IL5 MMP9
13
Show member pathways
11.98 IL13 IL4 IL5
14 11.79 CCL11 IL13 IL4 MMP9
15 11.68 IL13 IL4 IL5
16 11.66 IL13 IL4 IL5
17
Show member pathways
11.63 CD40LG IL4 IL5
18 11.56 CD40LG IL4 IL5
19 11.42 CCL11 CD40LG IL4 IL5
20 11.35 IL13 IL4
21 11.34 MMP9 PLAU
22 11.33 MMP9 PLAU
23
Show member pathways
11.3 MMP9 PLAU
24 11.2 CD40LG IL4 IL5
25 11.18 IL13 IL4 IL5
26 11.17 MMP9 PLAU
27 11.13 CD40LG MMP9
28 11.13 IL13 IL4 IL5
29 11.1 CD40LG IL4
30 11.05 IL13 IL4 IL5
31 10.92 CCL11 IL13 IL4 IL5
32 10.9 CCL11 IL13 IL4 IL5 MMP9 PLAU
33 10.84 CCL11 CD40LG IL13 IL4 IL5
34 10.78 CCL11 CD40LG IL13 IL4 IL5
35 10.62 IL13 IL4 IL5

GO Terms for Eosinophilic Meningitis

Cellular components related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CD40LG IL13 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.17 CCL11 CD40LG IL13 IL4 IL5 MMP9

Biological processes related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.62 CCL11 CD40LG IL13 IL5
2 positive regulation of cell migration GO:0030335 9.58 CCL11 MMP9 PLAU
3 chemotaxis GO:0006935 9.54 CCL11 IL4 PLAU
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.43 IL13 IL4
5 immune response GO:0006955 9.35 CCL11 CD40LG IL13 IL4 IL5
6 positive regulation of B cell proliferation GO:0030890 9.33 IL13 IL4 IL5
7 negative regulation of complement-dependent cytotoxicity GO:1903660 9.26 IL13 IL4
8 regulation of receptor activity GO:0010469 9.1 CCL11 CD40LG IL13 IL4 IL5 PLAU

Molecular functions related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 CD40LG IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Eosinophilic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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