MCID: ESN006
MIFTS: 45

Eosinophilic Meningitis malady

Summaries for Eosinophilic Meningitis

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32MalaCards
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MalaCards: Eosinophilic Meningitis is related to meningitis and angiostrongyliasis. An important gene associated with Eosinophilic Meningitis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Osteopontin Signaling and Osteopontin-mediated events. The compounds hydrocortisone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include brain and endothelial, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Classifications for Eosinophilic Meningitis

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8Disease Ontology, 60UMLS, 27ICD9CM, 56SNOMED-CT
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Aliases & Descriptions:

eosinophilic meningitis 8 60


External Ids:

Disease Ontology8 DOID:10361
SNOMED-CT56 25671008
ICD9CM27 322.1

Related Diseases for Eosinophilic Meningitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to eosinophilic meningitis

Clinical Features for Eosinophilic Meningitis

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Drugs & Therapeutics for Eosinophilic Meningitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Eosinophilic Meningitis

Drug clinical trials:

Search ClinicalTrials for Eosinophilic Meningitis

Search NIH Clinical Center for Eosinophilic Meningitis

Search CenterWatch for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

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Anatomical Context for Eosinophilic Meningitis

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32MalaCards
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MalaCards organs/tissues related to Eosinophilic Meningitis:

32
Brain, Endothelial

Animal Models for Eosinophilic Meningitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Eosinophilic Meningitis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.6IL2, IL4
2MP:00053889.5PLAU, MMP9, CCL24
3MP:00053899.3IL13, MMP9, PLAU
4MP:00020068.9IL10, IL5, IL2, MMP9
5MP:00053768.6IL13, IL5, IL4, IL2
6MP:00053707.7HGF, IL10, IL5, IL4, IL2, PLAU
7MP:00053817.6IL13, IL10, IL5, IL4, IL2, MMP9
8MP:00053877.1CCL24, IL13, IL10, IL5, IL4, IL2
9MP:00053846.9HGF, IL13, IL10, IL4, IL2, MMP9
10MP:00053786.7HGF, IL13, IL10, IL5, IL4, IL2
11MP:00107686.6HGF, IL13, IL10, IL4, IL2, MMP9
12MP:00053976.3HGF, CCL24, IL13, IL10, IL5, IL4

Publications for Eosinophilic Meningitis

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50PubMed
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Articles related to Eosinophilic Meningitis:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
Eosinophilic meningitis: what's the "diff"? (24060328)
2014
2
Eosinophilic meningitis. (23829911)
2013
3
Eosinophilic meningitis in a 10-year old nigerian boy: a case report. (24381722)
2013
4
Medical management of eosinophilic meningitis following bovine graft duraplasty for Chiari malformation Type I repair: case report. (23909615)
2013
5
The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected with Angiostrongylus cantonensis. (22152396)
2013
6
Molecular diagnosis of eosinophilic meningitis due to Angiostrongylus cantonensis (Nematoda: Metastrongyloidea) by polymerase chain reaction-DNA sequencing of cerebrospinal fluids of patients. (23440126)
2013
7
A case report on eosinophilic meningitis caused by Angiostrongylus cantonensis. (21897764)
2011
8
Sacral myeloradiculitis (Elsberg syndrome) secondary to eosinophilic meningitis caused by Angiostrongylus cantonensis. (21811516)
2009
9
Headache as the initial manifestation of neurocysticercosis: a case of eosinophilic meningitis. (19389136)
2009
10
Dynamic changes of hepatocyte growth factor in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. (19478261)
2009
11
Angiostrongylus cantonensis: effect of combination therapy with albendazole and dexamethasone on Th cytokine gene expression in PBMC from patients with eosinophilic meningitis. (19559022)
2009
12
Comparative efficacies of albendazole and the Chinese herbal medicine long-dan-xie-gan-tan, used alone or in combination, in the treatment of experimental eosinophilic meningitis induced by Angiostrongylus cantonensis. (18318936)
2008
13
Review of idiopathic eosinophilic meningitis in dogs and cats, with a detailed description of two recent cases in dogs. (19496320)
2008
14
Possible intrafamilial transmission of Toxocara causing eosinophilic meningitis in an infant. (18664926)
2008
15
Association of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-4 in cerebrospinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. (18187780)
2008
16
Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. (17703945)
2007
17
Distribution of eosinophilic meningitis cases attributable to Angiostrongylus cantonensis, Hawaii. (18217550)
2007
18
Full recovery from Baylisascaris procyonis eosinophilic meningitis. (17553240)
2007
19
Multi-immunodot for rapid differential diagnosis of eosinophilic meningitis due to parasitic infections. (16923267)
2006
20
Late-onset eosinophilic chronic meningitis occurring 30 years after Taenia solium infestation in a white Caucasian woman. (16253336)
2006
21
A 1-week course of corticosteroids in the treatment of eosinophilic meningitis. (15541333)
2004
22
Eosinophilic meningitis in a child raising snails as pets. (14739022)
2004
23
Treatment of eosinophilic meningitis with a combination of albendazole and corticosteroid. (15272765)
2004
24
Association of matrix metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis. (15449178)
2004
25
Fatal autochthonous eosinophilic meningitis in a Jamaican child caused by Angiostrongylus cantonensis. (15100458)
2004
26
Eosinophilic meningitis following incomplete resection of a meningeal hydatid cyst. (14723377)
2003
27
Eosinophilic meningitis. (12637136)
2003
28
Corticosteroid treatment of eosinophilic meningitis. (11017811)
2000
29
Angiostrongylus cantonensis eosinophilic meningitis. (10460929)
1999
30
Eosinophilic meningitis. (10778542)
1999
31
Angiostrongylus eosinophilic meningitis in Egypt. (8843838)
1996
32
Eosinophilic meningitis. (8356350)
1993
33
Eosinophilic meningitis. (8279176)
1993
34
Eosinophilic meningitis. (8368222)
1993
35
Eosinophilic meningitis beyond the Pacific Basin: the global dispersal of a peridomestic zoonosis caused by Angiostrongylus cantonensis, the nematode lungworm of rats. (1738873)
1992
36
Unusual manifestation of eosinophilic meningitis. (1488715)
1992
37
Eosinophilic meningitis due to Angiostrongylus cantonensis. (1620361)
1992
38
The discovery of Angiostrongylus cantonensis as a cause of human eosinophilic meningitis. (15463478)
1991
39
Angiostrongylus cantonensis and eosinophilic meningitis. (2904084)
1988
40
Eosinophilic meningitis after repeated lophendylate injection myelography. (7417069)
1980
41
Recovery of Angiostrongylus cantonensis from cerebrospinal fluid of a child with eosinophilic meningitis. (479360)
1979
42
Clinical manifestations and laboratory diagnosis of eosinophilic meningitis syndrome associated with angiostrongyliasis. (725650)
1978
43
Dirofilariasis as a cause of eosinophilic meningitis in man diagnosed by immunofluorescence and Arthus hypersensitivity. (4278682)
1974
44
Angiostrongylosis (eosinophilic meningitis). (5576817)
1971
45
Eosinophilic meningitis in Thailand. Epidemiologic studies of 484 typical cases and the etiologic role of Angiostrongylus cantonensis. (5531201)
1970
46
Eosinophilic meningitis in Okinawa. Three suspected cases of angiostrongyliasis in man. (5453904)
1970
47
Studies on eosinophilic meningitis. VI. Experimental infection of rats and other homoiothermic vertebrates with Angiostrongylus cantonensis. (5773425)
1969
48
Studies on eosinophilic meningitis. IV. Experimental infection of fresh-water and marine fish with Angiostrongylus cantonensis. (6025084)
1967
49
Eosinophilic meningitis. First reported cases on Guam, M.I. (4957679)
1966
50
Eosinophilic Meningitis. (5915858)
1966

Genetic Variations for Eosinophilic Meningitis

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Expression for genes affiliated with Eosinophilic Meningitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Eosinophilic Meningitis

Search GEO for disease gene expression data for Eosinophilic Meningitis.

Pathways for genes affiliated with Eosinophilic Meningitis

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Sources:
37NCBI BioSystems Database, 29KEGG, 52R&D Systems, 4Cell Signaling Technology, 59Tocris Bioscience, 51QIAGEN, 53Reactome, 12EMD Millipore
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Pathways related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8PLAU, MMP9
29.8PLAU, MMP9
39.8PLAU, MMP9
4
Hide members
9.5IL5, IL13
5
Hide members
9.5IL2, IL10
69.4IL2, IL13
79.3IL5, IL4, IL2
8
Hide members
9.3IL2, IL4, IL5
99.3HGF, MMP9
109.2IL4, IL2, MMP9
119.2IL10, IL5, IL4
12
Hide members
9.1IL10, IL2, MMP9
139.1IL13, IL5, IL4
149.1IL2, IL4, IL10
15
Hide members
9.1IL2, IL5, IL13
16
Hide members
9.1IL13, IL5, IL2
178.9PLAU, MMP9, HGF
18
Hide members
8.9HGF, MMP9, PLAU
198.9HGF, MMP9, PLAU
20
Hide members
8.9IL2, IL5, HGF
21
Hide members
8.8IL5, CCL24, HGF
22
Hide members
8.8IL2, IL4, IL5, IL10
23
Hide members
8.7IL2, IL4, IL5, IL13
248.7IL2, IL4, IL5, IL13
25
Hide members
8.6IL13, IL10, IL5, IL4
26
Hide members
8.2HGF, CCL24, IL13, IL5
27
Hide members
8.2HGF, CCL24, IL13, IL5
288.1IL13, IL10, IL5, IL4, IL2
298.1IL13, IL10, IL5, IL4, IL2
308.1IL2, IL4, IL5, IL10, IL13
31
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7.7HGF, CCL24, IL13, IL5, IL2
32
Hide members
6.8HGF, CCL24, IL13, IL10, IL5, IL4

Compounds for genes affiliated with Eosinophilic Meningitis

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.6PLAU
2gm-csf44 2811.4IL10
3aprotinin44 1111.1PLAU
4cycloheximide4410.1HGF
5rantes4410.1IL2, IL4
6pge2449.7PLAU, IL2, MMP9
7cyclophosphamide44 49 1111.6HGF, IL2
8omalizumab44 1110.4IL13, IL5, IL4
9indomethacin44 59 28 1112.4IL5, HGF, PLAU
10c-d4t449.4IL2, IL4, IL5
11interferon gamma449.3IL4, IL2, IL10
12con a449.1IL5, IL2, IL10, IL4
13polyinosinic-polycytidylic acid449.1IL10, IL5, IL4, IL2
14fluticasone propionate44 49 59 1112.1MMP9, IL5, IL13, IL4
15prednisolone44 28 1111.1IL13, IL5, HGF
16salmeterol44 49 28 1112.1IL13, IL2, IL4, IL5
17praziquantel44 1110.0IL4, IL5, IL10, IL13
18mip 1alpha449.0PLAU, IL10, IL13, IL4
19montelukast44 49 28 1112.0IL5, IL13, IL4, IL10
20ribavirin44 49 1110.9IL2, IL4, IL10, MMP9
21gabexate mesilate448.9PLAU, IL10, MMP9
22doxycycline44 119.9IL13, MMP9, PLAU, IL5
23as 10159 449.9IL13, IL5, IL10, IL2
24alpha-galactosylceramide448.9IL2, IL4, IL10, IL13
25dexamethasone44 49 28 1111.7HGF, IL5, IL13, MMP9
26acetaldehyde44 28 2410.6HGF, IL4, PLAU, IL10
27pentoxifylline44 119.6IL13, IL2, IL4, IL10
28allergens448.6IL10, IL4, IL5, IL13
29glatiramer acetate44 119.6IL10, IL13, IL2, IL4, IL5
30il-12448.6IL13, IL5, IL10, IL4, IL2
31ccl344 289.6CCL24, IL10, IL13, MMP9
32il 10448.6IL4, IL13, IL10, IL5, IL2
33tarc448.5IL10, CCL24, IL5, IL4, IL13
34ionomycin448.4IL10, IL5, IL4, IL2, IL13
35pdtc448.4IL4, HGF, PLAU, MMP9
36calcitriol44 59 11 2411.4IL10, IL13, PLAU, IL4, IL2
37bleomycin44 119.3HGF, MMP9, IL4, IL5, IL13
38dmso448.3IL10, HGF, IL2, PLAU, IL5
39herbimycin a44 599.2IL5, HGF, IL4, IL2, PLAU, MMP9
40tgf beta1448.1PLAU, HGF, IL10, MMP9, IL13
41thalidomide44 49 59 1111.1IL5, IL10, IL13, HGF, IL2
42paraffin448.0IL4, IL5, HGF, IL10, PLAU, MMP9
43adenylate447.8IL13, IL5, HGF, MMP9, PLAU, IL4
44tacrolimus44 49 119.7IL10, IL13, IL5, IL2, HGF, IL4
45sb 20358044 598.5IL5, PLAU, MMP9, IL4, HGF, IL13
46ly294002447.5PLAU, MMP9, IL5, IL10, IL13, HGF
47thymidine44 248.4HGF, IL10, IL4, IL13, IL5, PLAU
48actinomycin d447.3IL13, HGF, CCL24, IL4, MMP9, PLAU
49vegf447.0IL10, IL2, PLAU, HGF, IL13, IL5
50histamine44 28 248.9CCL24, IL13, HGF, IL10, IL5, IL4

GO Terms for genes affiliated with Eosinophilic Meningitis

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16Gene Ontology
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Cellular components related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5IL13, IL5, IL2, MMP9, PLAU, HGF
2extracellular spaceGO:0056155.8PLAU, HGF, CCL24, IL13, IL10, IL5

Biological processes related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:0510249.8IL2, IL5
2regulation of isotype switchingGO:0451919.8IL4, IL10
3type 2 immune responseGO:0420929.8IL4, IL10
4positive regulation of isotype switching to IgG isotypesGO:0483049.8IL2, IL4
5positive regulation of MHC class II biosynthetic processGO:0453489.7IL4, IL10
6regulation of proton transportGO:0101559.7IL13, IL4
7negative regulation of nitric oxide biosynthetic processGO:0450199.6IL4, IL10
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.5IL2, IL4
9positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.4IL10, IL5, IL4
10chemotaxisGO:0069359.3CCL24, IL4, PLAU
11positive regulation of activated T cell proliferationGO:0421049.3IL4, IL2
12positive regulation of B cell proliferationGO:0308909.0IL2, IL4, IL5, IL13
13inflammatory responseGO:0069548.7IL5, IL10, IL13, CCL24
14cell-cell signalingGO:0072678.6CCL24, IL13, IL10, IL2
15immune responseGO:0069558.4CCL24, IL13, IL5, IL4, IL2
16negative regulation of apoptotic processGO:0430668.3HGF, IL10, IL4, IL2
17positive regulation of transcription from RNA polymerase II promoterGO:0459448.3IL2, IL4, IL10, HGF

Molecular functions related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.1IL10, IL5, IL4, IL2, IL13
2growth factor activityGO:0080837.6IL2, IL4, IL5, IL10, HGF

Products for genes affiliated with Eosinophilic Meningitis

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  • Antibodies
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Sources for Eosinophilic Meningitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet