MCID: ESN006
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Eosinophilic Meningitis malady

Neuronal diseases category
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Summaries for Eosinophilic Meningitis

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MalaCards based summary: Eosinophilic Meningitis is related to meningitis and angiostrongyliasis. An important gene associated with Eosinophilic Meningitis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Selected targets of GCR alpha and Syndecan-1-mediated signaling events. The compounds omalizumab and ovomucoid have been mentioned in the context of this disorder. Affiliated tissues include brain and endothelial, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Eosinophilic Meningitis

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Eosinophilic Meningitis, Aliases & Descriptions:

Name: Eosinophilic Meningitis 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:10361
SNOMED-CT57 25671008
ICD9CM27 322.1

Related Diseases for Eosinophilic Meningitis

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Diseases related to Eosinophilic Meningitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis32.2MMP9
2angiostrongyliasis31.5MMP9
3sinusitis30.8IL5
4eosinophilia29.2CCL24, IL4, IL2, IL5, IL10, IL13
5eosinophilic fasciitis10.5IL5
6kimura disease10.5IL5
7eosinophilic esophagitis10.5IL5
8malaria10.4IL10
9intraocular lymphoma10.4IL10
10periapical granuloma10.4IL4
11meningoencephalitis10.4
12keratoconjunctivitis10.4IL5, IL13
13filariasis10.4IL13, IL5
14helminthiasis10.4IL5, IL13
15eosinophilic pneumonia10.3IL5, IL13
16leprosy10.3IL2
17esophagitis10.3IL13, IL5
18mastocytosis10.3IL5, IL13
19bronchiolitis10.3IL5, IL13
20egg allergy10.3IL5, IL4
21intrinsic asthma10.3IL4, IL5
22allergic bronchopulmonary aspergillosis10.3IL4, IL5
23omenn syndrome10.3IL5, IL4
24alcoholic hepatitis10.3IL10, HGF
25selective iga deficiency disease10.2IL4, IL10
26visceral leishmaniasis10.2IL4, IL10
27hydrocephalus10.2
28headache10.2
29conjunctivochalasis10.2PLAU, MMP9
30bullous pemphigoid10.2IL5, IL13, PLAU
31abdominal aortic aneurysm10.2MMP9, PLAU
32type 1 diabetes mellitus10.2IL10, IL4
33allergic conjunctivitis10.2IL4, IL5, IL13
34asthma10.1IL4, IL5, IL13
35pulmonary eosinophilia10.1IL4, IL5, IL13
36allergic rhinitis10.1IL13, IL5, IL4
37food allergy10.1IL4, IL5, IL13
38atopic dermatitis10.1IL13, IL4
39relapsing-remitting multiple sclerosis10.1MMP9, IL10
40rhinitis10.1IL4, IL5, IL13
41dermatitis10.1IL13, IL5, IL4
42proliferative diabetic retinopathy10.1MMP9, HGF
43bone cancer10.1MMP9, PLAU
44pneumonia10.1IL13, IL10, IL5
45bruton-type agammaglobulinemia10.1IL4, IL2
46idiopathic pulmonary fibrosis10.1HGF, IL13, MMP9
47mycosis fungoides10.1IL5, IL2
48periodontitis10.0IL10, MMP9
49colitis10.0IL13, IL10, IL4
50acute lymphoblastic leukemia10.0

Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to eosinophilic meningitis

Symptoms for Eosinophilic Meningitis

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Drugs & Therapeutics for Eosinophilic Meningitis

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Drug clinical trials:

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Search NIH Clinical Center for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

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Anatomical Context for Eosinophilic Meningitis

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MalaCards organs/tissues related to Eosinophilic Meningitis:

32
Brain, Endothelial

Animal Models for Eosinophilic Meningitis or affiliated genes

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MGI Mouse Phenotypes related to Eosinophilic Meningitis:

36 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9MMP9, IL2, IL5, IL10, PLAU
2MP:00030127.9IL4, IL2, IL10, IL13, HGF
3MP:00053857.7HGF, PLAU, IL10, IL2, MMP9
4MP:00053707.6IL4, IL2, IL5, IL10, PLAU, HGF
5MP:00053797.5IL4, IL2, IL10, IL13, PLAU
6MP:00053817.2MMP9, IL4, IL2, IL5, IL10, IL13
7MP:00053897.2MMP9, IL4, IL2, IL5, IL10, IL13
8MP:00053847.1MMP9, IL4, IL2, IL10, IL13, PLAU
9MP:00053767.0MMP9, IL4, IL2, IL5, IL10, IL13
10MP:00107686.8MMP9, IL4, IL2, IL10, IL13, PLAU
11MP:00053786.8MMP9, IL4, IL2, IL5, IL10, IL13
12MP:00053886.7PLAU, MMP9, CCL24, IL4, IL2, IL5
13MP:00053876.7MMP9, CCL24, IL4, IL2, IL5, IL10
14MP:00053976.3MMP9, CCL24, IL4, IL2, IL5, IL10

Publications for Eosinophilic Meningitis

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Articles related to Eosinophilic Meningitis:

(show top 50)    (show all 200)
idTitleAuthorsYear
1
Eosinophilic meningitis caused by Angiostrongylus cantonensis: an emergent disease in Brazil. (25075779)
2014
2
Angiostrongylus cantonensis eosinophilic meningitis: a clinical study of 42 consecutive cases in French Polynesia. (24583335)
2014
3
MicroRNA expressions associated with eosinophilic meningitis caused by Angiostrongylus cantonensis infection in a mouse model. (24682888)
2014
4
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an adolescent with mental retardation and pica disorder. (23445744)
2013
5
Eosinophilic meningitis. (23829911)
2013
6
Eosinophilic meningitis in a 10-year old nigerian boy: a case report. (24381722)
2013
7
Eosinophilic meningitis in a previously healthy 13-year-old child. (23328824)
2013
8
Medical management of eosinophilic meningitis following bovine graft duraplasty for Chiari malformation Type I repair: case report. (23909615)
2013
9
The use of albendazole and diammonium glycyrrhizinate in the treatment of eosinophilic meningitis in mice infected with Angiostrongylus cantonensis. (22152396)
2013
10
Corticosteroids for parasitic eosinophilic meningitis. (23076953)
2012
11
A case report on eosinophilic meningitis caused by Angiostrongylus cantonensis. (21897764)
2011
12
Sacral myeloradiculitis (Elsberg syndrome) secondary to eosinophilic meningitis caused by Angiostrongylus cantonensis. (21811516)
2009
13
Comparison of prednisolone plus albendazole with prednisolone alone for treatment of patients with eosinophilic meningitis. (19706911)
2009
14
Eosinophilic meningitis - an immunophenotyping recording of a very rare clinical entity - brief Report. (19649744)
2009
15
Cluster of eosinophilic meningitis attributable to Angiostrongylus cantonensis infection in French policemen troop returning from the Pacific Islands. (18760253)
2008
16
A case of eosinophilic meningitis in Germany. (18481034)
2008
17
Helminthic eosinophilic meningitis: emerging zoonotic diseases in the South. (19283982)
2008
18
Detection of circulating antibody of Parastrongylus cantonensis in sera with eosinophilic meningitis by dot-blot ELISA. (18839849)
2008
19
Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. (17703945)
2007
20
Multi-immunodot for rapid differential diagnosis of eosinophilic meningitis due to parasitic infections. (16923267)
2006
21
Chinese herbal medicine Yin-Chen-Extract as an adjunct to anthelmintic albendazole used against Angiostrongylus cantonensis-induced eosinophilic meningitis or meningoencephalitis. (16968941)
2006
22
Upregulation of MMP-9/TIMP-1 enzymatic system in eosinophilic meningitis caused by Angiostrongylus cantonensis. (15810979)
2005
23
Multilevel intramedullary spinal neurocysticercosis with eosinophilic meningitis. (15148157)
2004
24
Combined treatment with interleukin-12 and mebendazole lessens the severity of experimental eosinophilic meningitis caused by Angiostrongylus cantonensis in ICR mice. (12819081)
2003
25
Enzootic Angiostrongylus cantonensis in rats and snails after an outbreak of human eosinophilic meningitis, Jamaica. (11927033)
2002
26
Angiostrongylus cantonensis eosinophilic meningitis. (10460929)
1999
27
Eosinophilic meningitis in a newborn with group B streptococcal infection. (8265296)
1993
28
Eosinophilic meningitis. (8356350)
1993
29
Eosinophilic meningitis. (8279176)
1993
30
Eosinophilic meningitis beyond the Pacific Basin: the global dispersal of a peridomestic zoonosis caused by Angiostrongylus cantonensis, the nematode lungworm of rats. (1738873)
1992
31
Eosinophilic meningitis in Thailand. Clinical and epidemiological characteristics of 162 patients with myeloencephalitis probably caused by Gnathostoma spinigerum. (2376755)
1990
32
Eosinophilic meningitis--a case report and literature review. (2133754)
1990
33
Eosinophilic meningitis and radiculomyelitis in Thailand, caused by CNS invasion of Gnathostoma spinigerum and Angiostrongylus cantonensis. (3351533)
1988
34
Differential diagnosis of eosinophilic meningitis. (15463120)
1988
35
Eosinophilic meningitis preceding meningeal relapse in a child with acute lymphoblastic leukemia: abnormal nucleotide content of eosinophils. (3152930)
1987
36
Leptomeningeal carcinomatosis presenting as eosinophilic meningitis. (3456181)
1986
37
The chronic and severe forms of eosinophilic meningitis. (6591910)
1984
38
Eosinophilic meningitis. (6636755)
1983
39
Eosinophilic meningitis and hydrocephalus in an infant. (7092618)
1982
40
Eosinophilic meningitis in Hodgkin disease. (7195513)
1981
41
Eosinophilic meningitis. (294917)
1979
42
Eosinophilic meningitis in Hodgkin's disease. (517907)
1979
43
Nidality of eosinophilic meningitis with special reference to Angiostrongylus cantonensis. (632707)
1978
44
Clinical observations on eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis on Taiwan. (1259085)
1976
45
Case of ocular angiostrongyliasis associated with eosinophilic meningitis. (5102754)
1971
46
Lesions of the brain in eosinophilic meningitis. (5410412)
1970
47
Eosinophilic meningitis in Thailand. Epidemiologic studies of 484 typical cases and the etiologic role of Angiostrongylus cantonensis. (5531201)
1970
48
Studies on eosinophilic meningitis. V. Molluscan hosts of Angiostrongylus cantonensis on Pacific Islands. (5777734)
1969
49
Eosinophilic meningitis in Hodgkin's disease. (5348868)
1969
50
Studies on eosinophilic meningitis. IV. Experimental infection of fresh-water and marine fish with Angiostrongylus cantonensis. (6025084)
1967

Variations for Eosinophilic Meningitis

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Expression for genes affiliated with Eosinophilic Meningitis

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Expression patterns in normal tissues for genes affiliated with Eosinophilic Meningitis

Search GEO for disease gene expression data for Eosinophilic Meningitis.

Pathways for genes affiliated with Eosinophilic Meningitis

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Pathways related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7IL5, IL4
29.6HGF, MMP9
39.5PLAU, MMP9
49.5PLAU, MMP9
59.5PLAU, MMP9
69.5MMP9, PLAU
79.5IL2, IL13
8
Show member pathways
IL2 signaling events mediated by STAT537
9.4IL2, IL4
99.4IL13, IL5, IL4
10
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.4IL4, IL5, IL13
119.3HGF, IL10
12
Show member pathways
9.2IL13, IL5, IL2
13
Show member pathways
9.2IL13, IL5, IL2
149.2HGF, PLAU, MMP9
159.2HGF, PLAU, MMP9
16
Show member pathways
9.2HGF, IL5, IL2
17
Show member pathways
9.2IL2, IL5, HGF
189.1IL4, IL2, IL5
19
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.1IL5, IL2, IL4
20
Show member pathways
9.1IL4, IL2, IL13
21
Show member pathways
IL27-mediated signaling events37
9.0IL10, IL2
22
Show member pathways
9.0IL2, IL10
239.0HGF, IL2, IL4
24
Show member pathways
9.0HGF, IL2, IL4
258.9IL4, IL5, IL10
268.9IL2, IL4, MMP9
278.7IL4, IL2, IL5, IL13
288.6IL4, IL2, IL10
29
Show member pathways
8.5HGF, PLAU, IL2, MMP9
30
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5IL10, IL2, MMP9
31
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.3IL4, IL2, IL5, IL10
327.9IL4, IL2, IL5, IL10, IL13
337.9IL13, IL10, IL5, IL2, IL4
347.9IL4, IL2, IL5, IL10, IL13
35
Show member pathways
7.9IL4, IL2, IL5, IL10, IL13
36
Show member pathways
7.9IL4, IL2, IL5, IL10, IL13
37
Show member pathways
Type III interferon signaling37
7.9IL4, IL2, IL5, IL10, IL13
38
Show member pathways
7.0CCL24, IL4, IL2, IL5, IL10, IL13
39
Show member pathways
7.0CCL24, HGF, IL13, IL10, IL5, IL2
40
Show member pathways
7.0CCL24, IL4, IL2, IL5, IL10, IL13
41
Show member pathways
7.0CCL24, IL4, IL2, IL5, IL10, IL13
42
Show member pathways
7.0IL13, IL10, IL5, IL2, IL4, CCL24

Compounds for genes affiliated with Eosinophilic Meningitis

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Compounds related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show top 50)    (show all 186)
idCompoundScoreTop Affiliating Genes
1omalizumab44 1110.6IL13, IL5, IL4
2ovomucoid449.4IL13, IL4, IL5
3fluticasone propionate44 50 61 1112.1IL13, MMP9, IL5, IL4
4salmeterol44 50 28 1112.1IL4, IL2, IL13, IL5
5praziquantel44 119.9IL4, IL13, IL5, IL10
6montelukast44 50 28 1111.9IL13, IL10, IL5, IL4
7bleomycin44 119.8IL13, HGF, MMP9, IL4, IL5
8mip 1alpha448.8IL4, IL10, IL13, PLAU
9rolipram44 61 2810.8IL4, IL10, IL13, IL5
10doxycycline44 119.8MMP9, IL5, IL13, PLAU
11as 10144 619.7IL2, IL5, IL10, IL13
12interferon gamma448.7IL10, IL2, IL4
13alpha-galactosylceramide448.6IL2, IL10, IL4, IL13
14acetaldehyde28 44 2410.6HGF, PLAU, IL10, IL4
15con a448.6IL2, IL10, IL4, IL5
16polyinosinic-polycytidylic acid448.5IL4, IL2, IL5, IL10
17ivig448.5IL10, IL5, IL4, MMP9
18tarc448.4CCL24, IL4, IL5, IL10, IL13
19thalidomide44 50 61 1111.4IL10, IL2, IL5, IL13, HGF
20glatiramer acetate44 119.4IL4, IL13, IL10, IL5, IL2
21il-12448.3IL13, IL10, IL5, IL2, IL4
22gm-csf44 289.3IL10, IL5, IL2, IL4, IL13
23prednisolone44 28 1110.3IL2, HGF, IL5, IL10, IL13
24tgf beta1448.3PLAU, IL13, IL10, MMP9, HGF
25indomethacin44 28 61 1111.3HGF, IL13, IL5, PLAU, IL2, IL4
26il 10448.3IL5, IL13, IL10, IL2, IL4
27pentoxifylline44 119.3IL2, IL4, IL13, IL10
28adenylate448.3HGF, IL13, IL4, IL5, PLAU, MMP9
29ccl344 289.3IL13, MMP9, CCL24, IL10
30allergens448.2IL13, IL10, IL5, IL4
31ionomycin448.2IL13, IL2, IL10, IL5, IL4
32ribavirin44 50 1110.2MMP9, IL10, IL4, IL2
33dmso448.2IL2, HGF, IL5, IL10, PLAU
34herbimycin a44 619.2MMP9, IL4, IL2, HGF, PLAU, IL5
35calcitriol44 61 24 1111.1IL10, IL2, IL13, PLAU, IL4
36tacrolimus44 50 119.9IL2, HGF, IL13, IL10, IL5, IL4
37paraffin447.9HGF, PLAU, IL10, IL4, MMP9, IL5
38cyclophosphamide44 50 119.7IL13, HGF, MMP9, IL4, IL2, IL10
39sb 20358044 618.7IL10, IL13, PLAU, HGF, IL4, MMP9
40ly294002447.7PLAU, MMP9, HGF, IL13, IL10, IL5
41actinomycin d447.6IL4, PLAU, HGF, MMP9, CCL24, IL2
42hydrocortisone44 2 61 1110.6IL13, IL4, IL2, IL5, IL10, PLAU
43thymidine44 248.5IL13, PLAU, IL10, HGF, IL4, IL2
44cyclosporin a44 28 619.4HGF, IL13, IL10, IL5, IL2, IL4
45dexamethasone44 50 28 1110.4MMP9, IL4, IL2, IL5, IL10, IL13
46rantes447.3CCL24, IL4, IL2, IL5, IL13, IL10
47histamine44 28 249.1IL4, CCL24, HGF, IL2, IL5, IL10
48pge2447.1PLAU, IL13, HGF, IL10, IL5, IL2
49cycloheximide447.0IL2, MMP9, IL4, HGF, PLAU, IL13
50vegf447.0IL13, MMP9, IL4, IL10, HGF, IL2

GO Terms for genes affiliated with Eosinophilic Meningitis

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Cellular components related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.9MMP9, IL2, IL5, IL13, PLAU, HGF
2extracellular spaceGO:0056155.8MMP9, CCL24, IL4, IL2, IL5, IL10

Biological processes related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:01015510.0IL13, IL4
2positive regulation of immunoglobulin secretionGO:0510249.8IL2, IL5
3positive regulation of isotype switching to IgG isotypesGO:0483049.7IL4, IL2
4positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.5IL2, IL4
5regulation of isotype switchingGO:0451919.5IL10, IL4
6type 2 immune responseGO:0420929.5IL10, IL4
7positive regulation of activated T cell proliferationGO:0421049.5IL2, IL4
8positive regulation of MHC class II biosynthetic processGO:0453489.4IL4, IL10
9negative regulation of nitric oxide biosynthetic processGO:0450199.4IL10, IL4
10extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.3IL2, IL4
11chemotaxisGO:0069359.3CCL24, IL4, PLAU
12proteolysisGO:0065089.3MMP9, PLAU, HGF
13B cell differentiationGO:0301839.2IL10, IL4
14positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.1IL10, IL5, IL4
15positive regulation of B cell proliferationGO:0308909.1IL13, IL5, IL2, IL4
16positive regulation of inflammatory responseGO:0507299.0IL2, CCL24
17inflammatory responseGO:0069548.8CCL24, IL5, IL10, IL13
18immune responseGO:0069558.5CCL24, IL4, IL2, IL5, IL13
19cell-cell signalingGO:0072678.5CCL24, IL2, IL10, IL13
20negative regulation of apoptotic processGO:0430668.4HGF, IL10, IL2, IL4
21positive regulation of transcription from RNA polymerase II promoterGO:0459448.2IL4, IL2, IL10, HGF

Molecular functions related to Eosinophilic Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051257.9IL2, IL5, IL10, IL13, IL4
2growth factor activityGO:0080837.6HGF, IL10, IL5, IL2, IL4

Products for genes affiliated with Eosinophilic Meningitis

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Sources for Eosinophilic Meningitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet