MCID: EPN001
MIFTS: 34

Ependymoblastoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Ependymoblastoma

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Sources:
9Disease Ontology, 43Novoseek, 47Orphanet, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT, 61UMLS via Orphanet
See all sources

Ependymoblastoma, Aliases & Descriptions:

Name: Ependymoblastoma 9 43 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
ependymoblastoma:
Inheritance: Not applicable; Age of onset: Infancy,Neonatal


External Ids:

Disease Ontology9 DOID:4794
NCIt38 C4915
MeSH33 D018242
SNOMED-CT55 21589007, 253070006
Orphanet47 251880
UMLS via Orphanet61 C0700367

Summaries for Ependymoblastoma

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Wikipedia:63 Primitive neuroectodermal tumor (PNET) is a malignant (cancerous) neural crest tumor. It is a rare... more...

MalaCards based summary: Ependymoblastoma is related to neuroblastoma and ependymoma. An important gene associated with Ependymoblastoma is NGF (nerve growth factor (beta polypeptide)), and among its related pathways are SIDS Susceptibility Pathways and Development HGF signaling pathway. The compounds azathioprine and camptothecin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and pons, and related mouse phenotypes are vision/eye and cardiovascular system.

Related Diseases for Ependymoblastoma

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Graphical network of the top 20 diseases related to Ependymoblastoma:



Diseases related to ependymoblastoma

Symptoms for Ependymoblastoma

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Drugs & Therapeutics for Ependymoblastoma

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Drug clinical trials:

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Search NIH Clinical Center for Ependymoblastoma

Genetic Tests for Ependymoblastoma

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Anatomical Context for Ependymoblastoma

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MalaCards organs/tissues related to Ependymoblastoma:

31
Brain, Spinal cord, Pons

Animal Models for Ependymoblastoma or affiliated genes

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MGI Mouse Phenotypes related to Ependymoblastoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6TP73, NGF, GFAP
2MP:00053858.5TP73, NGF, GFAP
3MP:00053788.5TP73, NGF, GFAP
4MP:00053868.4GFAP, NGF, TP73
5MP:00036318.2TP73, NGF, GFAP

Publications for Ependymoblastoma

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Articles related to Ependymoblastoma:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
MET T992I mutation in a case of ependymoblastoma/embryonal tumour with multilayered rosettes. (25194039)
2014
2
A case report of an ependymoblastoma in the rectovaginal space and a review of the literature. (24511018)
2014
3
MRI characteristics of ependymoblastoma: results from 22 centrally reviewed cases. (24948504)
2014
4
Ependymoblastoma of the brainstem: MRI findings and differential diagnosis. (24464920)
2014
5
Ependymoblastoma with cystic change in a child. (24724717)
2014
6
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. (24337497)
2013
7
Ependymoblastoma in an adult: a diagnostic challenge on cytology. (22674109)
2011
8
Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006. (21308398)
2011
9
Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*. (19120373)
2010
10
Ependymoblastoma in a Japanese Black heifer. (19887749)
2009
11
Divergent ependymal tumor (ependymoblastoma/anaplastic ependymoma) of the posterior fossa: an uncommon case observed in a child. (18827270)
2008
12
Tumor suppressor proteins are differentially affected in human ependymoblastoma and medulloblastoma cells exposed to nerve growth factor. (17453820)
2007
13
In vitro human ependymoblastoma cells differentiate after exposure to nerve growth factor. (15906158)
2004
14
Ependymoblastoma: a clinical review. (8570066)
1995
15
Ependymoblastoma: MR presentation. A case report and review of the literature. (7491192)
1995
16
Ependymoblastoma in an HIV-positive hemophilic girl. (8084312)
1994
17
Tentorial traversal by ependymoblastoma. (1899507)
1991
18
Ependymoblastoma: a histological, immunohistological and ultrastructural study of five cases. (3286469)
1988
19
Congenital ependymoblastoma presenting as a sacrococcygeal mass in a newborn: an immunohistochemical, light and electron microscopic study. (3308267)
1987
20
The expression and detection of MHC class I antigens on murine neuroblastoma and ependymoblastoma lines. (3492512)
1987
21
Primary intracranial ependymoblastoma presenting as spinal cord compression due to metastasis. (3829033)
1986
22
The ultrastructure of the ependymoblastoma. (3776467)
1986
23
Primary leptomeningeal ependymoblastoma. Case report. (3701447)
1986
24
Ependymoblastoma. A reappraisal of a rare embryonal tumor. (3978547)
1985
25
Ependymoblastoma associated with prenatal exposure to diphenylhydantoin and methylphenobarbitone. (3978571)
1985
26
Ependymoblastoma in a dairy calf. (6485211)
1984
27
The murine ependymoblastoma: growth pattern and survival in C57Bl/6J mice. (6861007)
1983
28
Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma. (7388821)
1980
29
Congenital ependymoblastoma. (7188822)
1980
30
Isolation of plasma membranes from murine ependymoblastoma and subcellular distribution of amphotericin B in this tumor. (851531)
1977
31
Transplantation resistance to mouse ependymoblastoma following immunization with dehistonized syngeneic tumor chromatin. (1268848)
1976
32
Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by amphotericin B in murine ependymoblastoma. (975049)
1976
33
An ependymoblastoma of the pons. (1159567)
1975
34
Increased survival of mouse ependymoblastoma hosts previously treated with dehistonized tumor chromatin. (1153860)
1975
35
A mouse ependymoblastoma as an experimental model for screening potential antineoplastic drugs. (4447935)
1974
36
Recent experience with intrathecal radiogold for medulloblastoma and ependymoblastoma: a progress report. (4479529)
1974
37
The fine structure of ependymoblastoma. (4685709)
1973
38
Shortcomings of 99m Tc-pertechnetate as a tracer for brain tumor detection as shown by well counting of human brain tumors and a mouse ependymoblastoma. (4336247)
1972
39
Uptake and distribution of 3 H-methotrexate by the murine ependymoblastoma. (4537157)
1972
40
The uptake of hydrocortisone in mouse brain and ependymoblastoma. (5008732)
1972
41
Chemotherapy of brain tumors. Uptake of tritiated methotrexate by a transplantable intracerebral ependymoblastoma in mice. (5037043)
1972
42
Morphology of virus-like particles persisting in murine ependymoblastoma in vitro. (4323350)
1970
43
The definition of the ependymoblastoma. (5426275)
1970
44
Virus-like particles in murine ependymoblastoma. (4978021)
1969
45
Methotrexate permeability and steady-state distribution in the murine ependymoblastoma. (5374467)
1969
46
The ultrastructure of the mouse ependymoblastoma and its contained virus-like particles. (5656551)
1968
47
I. Observations on the differential diagnosis of medulloblastoma and ependymoblastoma. (4166631)
1967
48
The quantitative histochemistry of a chemically induced ependymoblastoma. II. The effect of ischaemia on substrates of carbohydrate metabolism. (5924668)
1966
49
Ependymoblastoma grossly eroding and involving overlying dura and skull; report of a case. (14824984)
1951
50
Unilateral infiltrative cellular ependymoblastoma; a case report. (15435069)
1950

Variations for Ependymoblastoma

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Expression for genes affiliated with Ependymoblastoma

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Search GEO for disease gene expression data for Ependymoblastoma.

Pathways for genes affiliated with Ependymoblastoma

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Pathways related to Ependymoblastoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TP73, NGF
2
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.3TP73, NGF
3
Show member pathways
9.0NGF, GFAP
49.0NGF, GFAP

Compounds for genes affiliated with Ependymoblastoma

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Compounds related to Ependymoblastoma according to GeneCards Suite gene sharing:

(show all 39)
idCompoundScoreTop Affiliating Genes
1azathioprine43 2 49 1212.7NGF, TP73
2camptothecin43 59 1211.7NGF, TP73
35fluorouracil439.7TP73, NGF
4chloramphenicol43 2 49 1212.6TP73, NGF
5actinomycin d439.6TP73, NGF
6propentofylline439.5NGF, GFAP
7silicone439.4GFAP, NGF
86-hydroxydopamine439.4NGF, GFAP
9mptp439.4NGF, GFAP
10neomycin439.4GFAP, NGF
11theophylline43 28 24 1212.4NGF, GFAP
12ganglioside439.4NGF, GFAP
13dbc-amp439.4NGF, GFAP
14morphine43 49 28 1212.4NGF, GFAP
15cytarabine43 49 1211.4NGF, GFAP
16cocaine43 1210.4NGF, GFAP
17choline43 24 1211.4GFAP, NGF
18paraffin439.4GFAP, TP73
19quercetin43 59 24 1212.4NGF, GFAP
20matrigel439.3GFAP, NGF
21nmda43 2810.3NGF, GFAP
22acetylcholine43 49 28 24 1213.3NGF, GFAP
23pd 98,059439.3GFAP, NGF
24forskolin43 49 1211.3NGF, GFAP
25genistein43 28 59 2 24 1214.2NGF, GFAP
26glutamine439.2GFAP, NGF
27cisplatin43 49 59 1212.2TP73, GFAP
28dopamine43 28 24 1212.2NGF, GFAP
29thymidine43 2410.1GFAP, NGF
30creatinine439.0NGF, GFAP
31cycloheximide439.0NGF, GFAP
32tetracycline43 129.9TP73, NGF, GFAP
33adenylate438.9GFAP, NGF
34vegf438.9GFAP, NGF, TP73
35arginine438.9GFAP, NGF, TP73
36threonine438.9TP73, NGF, GFAP
37retinoic acid43 249.9GFAP, NGF, TP73
38tyrosine438.8GFAP, NGF, TP73
39cyclic amp43 249.7NGF, GFAP

GO Terms for genes affiliated with Ependymoblastoma

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Biological processes related to Ependymoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00069549.3TP73, NGF
2negative regulation of neuron apoptotic processGO:00435249.2TP73, NGF
3positive regulation of apoptotic processGO:00430659.0TP73, NGF

Products for genes affiliated with Ependymoblastoma

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Sources for Ependymoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet