MCID: EPN001
MIFTS: 27

Ependymoblastoma malady

Neuronal, Cancer categories

Summaries for Ependymoblastoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Primitive Neuroectodermal Tumor (PNET) is a neural crest tumor. It is a rare tumor, usually occurring in... more...

MalaCards: Ependymoblastoma is related to ependymoma and adult ependymoblastoma. An important gene associated with Ependymoblastoma is NGF (nerve growth factor (beta polypeptide)), and among its related pathways are PIP3 activates AKT signaling and SIDS Susceptibility Pathways. The compounds propentofylline and silicone have been mentioned in the context of this disorder. Related mouse phenotype behavior/neurological.

Aliases & Classifications for Ependymoblastoma

Sources:
8Disease Ontology, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
ependymoblastoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

ependymoblastoma 8 45 49 61


External Ids:

Disease Ontology8 DOID:4794
MeSH35 D018242
SNOMED-CT57 21589007, 253070006
NCIt40 C4915

Related Diseases for Ependymoblastoma

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Ependymoblastoma:



Diseases related to ependymoblastoma

Clinical Features for Ependymoblastoma

Drugs & Therapeutics for Ependymoblastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Ependymoblastoma

Drug clinical trials:

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Search NIH Clinical Center for Ependymoblastoma

Search CenterWatch for Ependymoblastoma

Genetic Tests for Ependymoblastoma

Anatomical Context for Ependymoblastoma

Animal Models for Ependymoblastoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Ependymoblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.0TP73, GFAP, GLS, NGF

Publications for Ependymoblastoma

Sources:
51PubMed
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Articles related to Ependymoblastoma:

(show top 50)    (show all 51)
idTitleAuthorsYear
1
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. (24337497)
2013
2
Ependymoblastoma in an adult: a diagnostic challenge on cytology. (22674109)
2011
3
Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006. (21308398)
2011
4
Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*. (19120373)
2010
5
Ependymoblastoma in a Japanese Black heifer. (19887749)
2009
6
Ependymoblastomatous exencephaly: a unique fetal malformation. (18078364)
2008
7
Divergent ependymal tumor (ependymoblastoma/anaplastic ependymoma) of the posterior fossa: an uncommon case observed in a child. (18827270)
2008
8
Tumor suppressor proteins are differentially affected in human ependymoblastoma and medulloblastoma cells exposed to nerve growth factor. (17453820)
2007
9
In vitro human ependymoblastoma cells differentiate after exposure to nerve growth factor. (15906158)
2004
10
Ependymoblastoma: a clinical review. (8570066)
1995
11
Ependymoblastoma: MR presentation. A case report and review of the literature. (7491192)
1995
12
Ependymoblastoma in an HIV-positive hemophilic girl. (8084312)
1994
13
Tentorial traversal by ependymoblastoma. (1899507)
1991
14
Limits of tumour treatment follow up by surface coil 31P magnetic resonance spectroscopy. The case of sarcosinamide-CNU treated ependymoblastoma. (2484278)
1989
15
Ependymoblastoma: a histological, immunohistological and ultrastructural study of five cases. (3286469)
1988
16
Congenital ependymoblastoma presenting as a sacrococcygeal mass in a newborn: an immunohistochemical, light and electron microscopic study. (3308267)
1987
17
The expression and detection of MHC class I antigens on murine neuroblastoma and ependymoblastoma lines. (3492512)
1987
18
Primary intracranial ependymoblastoma presenting as spinal cord compression due to metastasis. (3829033)
1986
19
The ultrastructure of the ependymoblastoma. (3776467)
1986
20
Primary leptomeningeal ependymoblastoma. Case report. (3701447)
1986
21
Ependymoblastoma. A reappraisal of a rare embryonal tumor. (3978547)
1985
22
Ependymoblastoma associated with prenatal exposure to diphenylhydantoin and methylphenobarbitone. (3978571)
1985
23
Ependymoblastoma in a dairy calf. (6485211)
1984
24
The murine ependymoblastoma: growth pattern and survival in C57Bl/6J mice. (6861007)
1983
25
Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma. (7388821)
1980
26
Congenital ependymoblastoma. (7188822)
1980
27
Inhibition of RNA synthesis in murine ependymoblastoma by the combination of amphotericin B and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. (7471107)
1980
28
Isolation of plasma membranes from murine ependymoblastoma and subcellular distribution of amphotericin B in this tumor. (851531)
1977
29
Nonspecific inhibition of tumor growth in the central nervous system: observations of intracerebral ependymoblastoma in mice with chronic Toxoplasma infection. (894752)
1977
30
Transplantation resistance to mouse ependymoblastoma following immunization with dehistonized syngeneic tumor chromatin. (1268848)
1976
31
Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by amphotericin B in murine ependymoblastoma. (975049)
1976
32
An ependymoblastoma of the pons. (1159567)
1975
33
Increased survival of mouse ependymoblastoma hosts previously treated with dehistonized tumor chromatin. (1153860)
1975
34
A mouse ependymoblastoma as an experimental model for screening potential antineoplastic drugs. (4447935)
1974
35
Recent experience with intrathecal radiogold for medulloblastoma and ependymoblastoma: a progress report. (4479529)
1974
36
The fine structure of ependymoblastoma. (4685709)
1973
37
Shortcomings of 99m Tc-pertechnetate as a tracer for brain tumor detection as shown by well counting of human brain tumors and a mouse ependymoblastoma. (4336247)
1972
38
Uptake and distribution of 3 H-methotrexate by the murine ependymoblastoma. (4537157)
1972
39
The uptake of hydrocortisone in mouse brain and ependymoblastoma. (5008732)
1972
40
Chemotherapy of brain tumors. Uptake of tritiated methotrexate by a transplantable intracerebral ependymoblastoma in mice. (5037043)
1972
41
Morphology of virus-like particles persisting in murine ependymoblastoma in vitro. (4323350)
1970
42
The definition of the ependymoblastoma. (5426275)
1970
43
Virus-like particles in murine ependymoblastoma. (4978021)
1969
44
Methotrexate permeability and steady-state distribution in the murine ependymoblastoma. (5374467)
1969
45
The ultrastructure of the mouse ependymoblastoma and its contained virus-like particles. (5656551)
1968
46
I. Observations on the differential diagnosis of medulloblastoma and ependymoblastoma. (4166631)
1967
47
The quantitative histochemistry of a chemically induced ependymoblastoma. II. The effect of ischaemia on substrates of carbohydrate metabolism. (5924668)
1966
48
The quantitative histochemistry of a chemically induced ependymoblastoma. I. Enzymes. (4380815)
1966
49
Ependymoblastoma grossly eroding and involving overlying dura and skull; report of a case. (14824984)
1951
50
Unilateral infiltrative cellular ependymoblastoma; a case report. (15435069)
1950

Genetic Variations for Ependymoblastoma

Expression for genes affiliated with Ependymoblastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ependymoblastoma

Search GEO for disease gene expression data for Ependymoblastoma.

Pathways for genes affiliated with Ependymoblastoma

Sources:
54Reactome, 38NCBI BioSystems Database
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Pathways related to Ependymoblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3GFAP, NGF
29.1TP73, NGF

Compounds for genes affiliated with Ependymoblastoma

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
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Compounds related to Ependymoblastoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1propentofylline459.7GFAP, NGF
2silicone459.7GFAP, NGF
3quinolinic acid45 2410.7GLS, GFAP
46-hydroxydopamine459.7NGF, GFAP
5mptp459.7NGF, GFAP
6neomycin459.6NGF, GFAP
7theophylline45 29 11 2412.6NGF, GFAP
8ganglioside459.6GFAP, NGF
9dbc-amp459.6NGF, GFAP
10morphine45 50 29 1112.5NGF, GFAP
11cytarabine45 50 1111.4NGF, GFAP
12azathioprine45 50 2 1112.4NGF, TP73
13cocaine45 1110.3GFAP, NGF
14quercetin45 60 11 2412.3NGF, GFAP
15camptothecin45 60 1111.2NGF, TP73
16choline45 11 2411.2GFAP, GLS, NGF
17nmda45 2910.2GLS, NGF, GFAP
18glutamine459.1GFAP, GLS, NGF
19dexamethasone45 50 29 1112.1GFAP, GLS, NGF
20glutamate459.0GFAP, NGF, GLS
21alanine459.0GFAP, GLS, NGF
22actinomycin d459.0TP73, NGF, GLS
23tetracycline45 119.9TP73, GFAP, NGF
24vegf458.8TP73, GFAP, NGF
25threonine458.8NGF, GFAP, TP73
26cysteine458.5GFAP, NGF, GLS
27retinoic acid45 249.4TP73, GFAP, NGF
28arginine458.4NGF, GLS, GFAP, TP73

GO Terms for genes affiliated with Ependymoblastoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Ependymoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of neuron apoptotic processGO:0435249.1TP73, NGF

Products for genes affiliated with Ependymoblastoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ependymoblastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet