MCID: EPN001
MIFTS: 40

Ependymoblastoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories
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Summaries for Ependymoblastoma

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Wikipedia:65 Primitive Neuroectodermal Tumor (PNET) is a malignant (cancerous) neural crest tumor. It is a rare... more...

MalaCards based summary: Ependymoblastoma is related to neuroblastoma and ependymoma. An important gene associated with Ependymoblastoma is NGF (nerve growth factor (beta polypeptide)), and among its related pathways are SIDS Susceptibility Pathways and Development HGF signaling pathway. The compounds azathioprine and camptothecin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and pons, and related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Ependymoblastoma

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Sources:
8Disease Ontology, 44Novoseek, 48Orphanet, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH, 63UMLS via Orphanet
See all sources

Ependymoblastoma, Aliases & Descriptions:

Name: Ependymoblastoma 8 44 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
ependymoblastoma:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


External Ids:

Disease Ontology8 DOID:4794
NCIt39 C4915
SNOMED-CT57 21589007, 253070006
MeSH34 D018242
UMLS via Orphanet63 C0700367

Related Diseases for Ependymoblastoma

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Graphical network of the top 20 diseases related to Ependymoblastoma:



Diseases related to ependymoblastoma

Symptoms for Ependymoblastoma

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Drugs & Therapeutics for Ependymoblastoma

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Drug clinical trials:

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Genetic Tests for Ependymoblastoma

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Anatomical Context for Ependymoblastoma

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MalaCards organs/tissues related to Ependymoblastoma:

32
Brain, Spinal cord, Pons

Animal Models for Ependymoblastoma or affiliated genes

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MGI Mouse Phenotypes related to Ependymoblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6TP73, NGF, GFAP
2MP:00053858.5TP73, NGF, GFAP
3MP:00053788.5TP73, NGF, GFAP
4MP:00053868.4GFAP, NGF, TP73
5MP:00036318.2TP73, NGF, GFAP

Publications for Ependymoblastoma

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Articles related to Ependymoblastoma:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
MET T992I mutation in a case of ependymoblastoma/embryonal tumour with multilayered rosettes. (25194039)
2014
2
A case report of an ependymoblastoma in the rectovaginal space and a review of the literature. (24511018)
2014
3
MRI characteristics of ependymoblastoma: results from 22 centrally reviewed cases. (24948504)
2014
4
Ependymoblastoma of the brainstem: MRI findings and differential diagnosis. (24464920)
2014
5
Ependymoblastoma with cystic change in a child. (24724717)
2014
6
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. (24337497)
2013
7
Ependymoblastoma in an adult: a diagnostic challenge on cytology. (22674109)
2011
8
Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006. (21308398)
2011
9
Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*. (19120373)
2010
10
Ependymoblastoma in a Japanese Black heifer. (19887749)
2009
11
Divergent ependymal tumor (ependymoblastoma/anaplastic ependymoma) of the posterior fossa: an uncommon case observed in a child. (18827270)
2008
12
Tumor suppressor proteins are differentially affected in human ependymoblastoma and medulloblastoma cells exposed to nerve growth factor. (17453820)
2007
13
In vitro human ependymoblastoma cells differentiate after exposure to nerve growth factor. (15906158)
2004
14
Ependymoblastoma: a clinical review. (8570066)
1995
15
Ependymoblastoma: MR presentation. A case report and review of the literature. (7491192)
1995
16
Ependymoblastoma in an HIV-positive hemophilic girl. (8084312)
1994
17
Tentorial traversal by ependymoblastoma. (1899507)
1991
18
Ependymoblastoma: a histological, immunohistological and ultrastructural study of five cases. (3286469)
1988
19
Congenital ependymoblastoma presenting as a sacrococcygeal mass in a newborn: an immunohistochemical, light and electron microscopic study. (3308267)
1987
20
The expression and detection of MHC class I antigens on murine neuroblastoma and ependymoblastoma lines. (3492512)
1987
21
Primary intracranial ependymoblastoma presenting as spinal cord compression due to metastasis. (3829033)
1986
22
The ultrastructure of the ependymoblastoma. (3776467)
1986
23
Primary leptomeningeal ependymoblastoma. Case report. (3701447)
1986
24
Ependymoblastoma. A reappraisal of a rare embryonal tumor. (3978547)
1985
25
Ependymoblastoma associated with prenatal exposure to diphenylhydantoin and methylphenobarbitone. (3978571)
1985
26
Ependymoblastoma in a dairy calf. (6485211)
1984
27
The murine ependymoblastoma: growth pattern and survival in C57Bl/6J mice. (6861007)
1983
28
Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma. (7388821)
1980
29
Congenital ependymoblastoma. (7188822)
1980
30
Isolation of plasma membranes from murine ependymoblastoma and subcellular distribution of amphotericin B in this tumor. (851531)
1977
31
Transplantation resistance to mouse ependymoblastoma following immunization with dehistonized syngeneic tumor chromatin. (1268848)
1976
32
Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by amphotericin B in murine ependymoblastoma. (975049)
1976
33
An ependymoblastoma of the pons. (1159567)
1975
34
Increased survival of mouse ependymoblastoma hosts previously treated with dehistonized tumor chromatin. (1153860)
1975
35
A mouse ependymoblastoma as an experimental model for screening potential antineoplastic drugs. (4447935)
1974
36
Recent experience with intrathecal radiogold for medulloblastoma and ependymoblastoma: a progress report. (4479529)
1974
37
The fine structure of ependymoblastoma. (4685709)
1973
38
Shortcomings of 99m Tc-pertechnetate as a tracer for brain tumor detection as shown by well counting of human brain tumors and a mouse ependymoblastoma. (4336247)
1972
39
Uptake and distribution of 3 H-methotrexate by the murine ependymoblastoma. (4537157)
1972
40
The uptake of hydrocortisone in mouse brain and ependymoblastoma. (5008732)
1972
41
Chemotherapy of brain tumors. Uptake of tritiated methotrexate by a transplantable intracerebral ependymoblastoma in mice. (5037043)
1972
42
Morphology of virus-like particles persisting in murine ependymoblastoma in vitro. (4323350)
1970
43
The definition of the ependymoblastoma. (5426275)
1970
44
Virus-like particles in murine ependymoblastoma. (4978021)
1969
45
Methotrexate permeability and steady-state distribution in the murine ependymoblastoma. (5374467)
1969
46
The ultrastructure of the mouse ependymoblastoma and its contained virus-like particles. (5656551)
1968
47
I. Observations on the differential diagnosis of medulloblastoma and ependymoblastoma. (4166631)
1967
48
The quantitative histochemistry of a chemically induced ependymoblastoma. II. The effect of ischaemia on substrates of carbohydrate metabolism. (5924668)
1966
49
Ependymoblastoma grossly eroding and involving overlying dura and skull; report of a case. (14824984)
1951
50
Unilateral infiltrative cellular ependymoblastoma; a case report. (15435069)
1950

Variations for Ependymoblastoma

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Expression for genes affiliated with Ependymoblastoma

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Expression patterns in normal tissues for genes affiliated with Ependymoblastoma

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Pathways for genes affiliated with Ependymoblastoma

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Pathways related to Ependymoblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TP73, NGF
2
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3TP73, NGF
3
Show member pathways
9.0NGF, GFAP
49.0NGF, GFAP

Compounds for genes affiliated with Ependymoblastoma

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Compounds related to Ependymoblastoma according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1azathioprine44 2 50 1112.7NGF, TP73
2camptothecin44 61 1111.7NGF, TP73
35fluorouracil449.7TP73, NGF
4chloramphenicol44 2 50 1112.6TP73, NGF
5actinomycin d449.6TP73, NGF
6propentofylline449.5NGF, GFAP
7silicone449.4GFAP, NGF
86-hydroxydopamine449.4NGF, GFAP
9mptp449.4NGF, GFAP
10neomycin449.4GFAP, NGF
11theophylline44 28 24 1112.4NGF, GFAP
12ganglioside449.4NGF, GFAP
13dbc-amp449.4NGF, GFAP
14morphine44 50 28 1112.4NGF, GFAP
15cytarabine44 50 1111.4NGF, GFAP
16cocaine44 1110.4NGF, GFAP
17choline44 24 1111.4GFAP, NGF
18paraffin449.4GFAP, TP73
19quercetin44 61 24 1112.4NGF, GFAP
20matrigel449.3GFAP, NGF
21nmda44 2810.3NGF, GFAP
22acetylcholine44 50 28 24 1113.3NGF, GFAP
23pd 98,059449.3GFAP, NGF
24forskolin44 50 1111.3NGF, GFAP
25genistein44 28 61 2 24 1114.2NGF, GFAP
26glutamine449.2GFAP, NGF
27cisplatin44 50 61 1112.2TP73, GFAP
28dopamine44 28 24 1112.2NGF, GFAP
29thymidine44 2410.1GFAP, NGF
30creatinine449.0NGF, GFAP
31cycloheximide449.0NGF, GFAP
32tetracycline44 119.9TP73, NGF, GFAP
33adenylate448.9GFAP, NGF
34vegf448.9GFAP, NGF, TP73
35arginine448.9GFAP, NGF, TP73
36threonine448.9TP73, NGF, GFAP
37retinoic acid44 249.9GFAP, NGF, TP73
38tyrosine448.8GFAP, NGF, TP73
39cyclic amp44 249.7NGF, GFAP

GO Terms for genes affiliated with Ependymoblastoma

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Biological processes related to Ependymoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:0069549.3TP73, NGF
2negative regulation of neuron apoptotic processGO:0435249.2TP73, NGF
3positive regulation of apoptotic processGO:0430659.0TP73, NGF

Products for genes affiliated with Ependymoblastoma

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Sources for Ependymoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet