MCID: EPN001
MIFTS: 40

Ependymoblastoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories
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Summaries for Ependymoblastoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Primitive Neuroectodermal Tumor (PNET) is a malignant (cancerous) neural crest tumor. It is a rare... more...

MalaCards: Ependymoblastoma is related to medulloblastoma and neuroblastoma. An important gene associated with Ependymoblastoma is NGF (nerve growth factor (beta polypeptide)), and among its related pathways are SIDS Susceptibility Pathways and Development HGF signaling pathway. The compounds azathioprine and camptothecin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and pons, and related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Ependymoblastoma

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8Disease Ontology, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH, 63UMLS via Orphanet, 59SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
ependymoblastoma:
Inheritance: Sporadic; Age of onset: Neonatal/infancy


Aliases & Descriptions:

ependymoblastoma 8 45 49 62


External Ids:

Disease Ontology8 DOID:4794
NCIt40 C4915
MeSH35 D018242
SNOMED-CT58 21589007, 253070006
UMLS via Orphanet63 C0700367
SNOMED-CT via Orphanet59 21589007

Related Diseases for Ependymoblastoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Ependymoblastoma:



Diseases related to ependymoblastoma

Symptoms for Ependymoblastoma

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Drugs & Therapeutics for Ependymoblastoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Ependymoblastoma

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Anatomical Context for Ependymoblastoma

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33MalaCards
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MalaCards organs/tissues related to Ependymoblastoma:

33
Brain, Spinal cord, Pons

Animal Models for Ependymoblastoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Ependymoblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6TP73, NGF, GFAP
2MP:00053858.5TP73, NGF, GFAP
3MP:00053788.5TP73, NGF, GFAP
4MP:00053868.4GFAP, NGF, TP73
5MP:00036318.2TP73, NGF, GFAP

Publications for Ependymoblastoma

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52PubMed
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Articles related to Ependymoblastoma:

(show all 50)
idTitleAuthorsYear
1
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. (24337497)
2013
2
Ependymoblastoma in an adult: a diagnostic challenge on cytology. (22674109)
2011
3
Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006. (21308398)
2011
4
Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*. (19120373)
2010
5
Ependymoblastoma in a Japanese Black heifer. (19887749)
2009
6
Divergent ependymal tumor (ependymoblastoma/anaplastic ependymoma) of the posterior fossa: an uncommon case observed in a child. (18827270)
2008
7
Congenital ependymoblastoma arising in the sacrococcygeal soft tissue: a case study. (18402386)
2008
8
Tumor suppressor proteins are differentially affected in human ependymoblastoma and medulloblastoma cells exposed to nerve growth factor. (17453820)
2007
9
In vitro human ependymoblastoma cells differentiate after exposure to nerve growth factor. (15906158)
2004
10
Ependymoblastoma: a clinical review. (8570066)
1995
11
Ependymoblastoma: MR presentation. A case report and review of the literature. (7491192)
1995
12
Ependymoblastoma in an HIV-positive hemophilic girl. (8084312)
1994
13
Tentorial traversal by ependymoblastoma. (1899507)
1991
14
Limits of tumour treatment follow up by surface coil 31P magnetic resonance spectroscopy. The case of sarcosinamide-CNU treated ependymoblastoma. (2484278)
1989
15
Ependymoblastoma: a histological, immunohistological and ultrastructural study of five cases. (3286469)
1988
16
Congenital ependymoblastoma presenting as a sacrococcygeal mass in a newborn: an immunohistochemical, light and electron microscopic study. (3308267)
1987
17
The expression and detection of MHC class I antigens on murine neuroblastoma and ependymoblastoma lines. (3492512)
1987
18
Primary intracranial ependymoblastoma presenting as spinal cord compression due to metastasis. (3829033)
1986
19
The ultrastructure of the ependymoblastoma. (3776467)
1986
20
Primary leptomeningeal ependymoblastoma. Case report. (3701447)
1986
21
Ependymoblastoma. A reappraisal of a rare embryonal tumor. (3978547)
1985
22
Ependymoblastoma associated with prenatal exposure to diphenylhydantoin and methylphenobarbitone. (3978571)
1985
23
Ependymoblastoma in a dairy calf. (6485211)
1984
24
The murine ependymoblastoma: growth pattern and survival in C57Bl/6J mice. (6861007)
1983
25
Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma. (7388821)
1980
26
Congenital ependymoblastoma. (7188822)
1980
27
Inhibition of RNA synthesis in murine ependymoblastoma by the combination of amphotericin B and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. (7471107)
1980
28
Isolation of plasma membranes from murine ependymoblastoma and subcellular distribution of amphotericin B in this tumor. (851531)
1977
29
Nonspecific inhibition of tumor growth in the central nervous system: observations of intracerebral ependymoblastoma in mice with chronic Toxoplasma infection. (894752)
1977
30
Transplantation resistance to mouse ependymoblastoma following immunization with dehistonized syngeneic tumor chromatin. (1268848)
1976
31
Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by amphotericin B in murine ependymoblastoma. (975049)
1976
32
An ependymoblastoma of the pons. (1159567)
1975
33
Increased survival of mouse ependymoblastoma hosts previously treated with dehistonized tumor chromatin. (1153860)
1975
34
A mouse ependymoblastoma as an experimental model for screening potential antineoplastic drugs. (4447935)
1974
35
Recent experience with intrathecal radiogold for medulloblastoma and ependymoblastoma: a progress report. (4479529)
1974
36
The fine structure of ependymoblastoma. (4685709)
1973
37
Shortcomings of 99m Tc-pertechnetate as a tracer for brain tumor detection as shown by well counting of human brain tumors and a mouse ependymoblastoma. (4336247)
1972
38
Uptake and distribution of 3 H-methotrexate by the murine ependymoblastoma. (4537157)
1972
39
The uptake of hydrocortisone in mouse brain and ependymoblastoma. (5008732)
1972
40
Chemotherapy of brain tumors. Uptake of tritiated methotrexate by a transplantable intracerebral ependymoblastoma in mice. (5037043)
1972
41
Morphology of virus-like particles persisting in murine ependymoblastoma in vitro. (4323350)
1970
42
The definition of the ependymoblastoma. (5426275)
1970
43
Virus-like particles in murine ependymoblastoma. (4978021)
1969
44
Methotrexate permeability and steady-state distribution in the murine ependymoblastoma. (5374467)
1969
45
The ultrastructure of the mouse ependymoblastoma and its contained virus-like particles. (5656551)
1968
46
I. Observations on the differential diagnosis of medulloblastoma and ependymoblastoma. (4166631)
1967
47
The quantitative histochemistry of a chemically induced ependymoblastoma. II. The effect of ischaemia on substrates of carbohydrate metabolism. (5924668)
1966
48
The quantitative histochemistry of a chemically induced ependymoblastoma. I. Enzymes. (4380815)
1966
49
Ependymoblastoma grossly eroding and involving overlying dura and skull; report of a case. (14824984)
1951
50
Unilateral infiltrative cellular ependymoblastoma; a case report. (15435069)
1950

Variations for Ependymoblastoma

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Expression for genes affiliated with Ependymoblastoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ependymoblastoma

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Pathways for genes affiliated with Ependymoblastoma

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG, 55Reactome, 5Cell Signaling Technology
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Pathways related to Ependymoblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3TP73, NGF
2
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.3TP73, NGF
3
Show member pathways
9.0NGF, GFAP
49.0NGF, GFAP

Compounds for genes affiliated with Ependymoblastoma

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45Novoseek, 3BitterDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Ependymoblastoma according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1azathioprine45 3 51 1112.7NGF, TP73
2camptothecin45 61 1111.7NGF, TP73
35fluorouracil459.7TP73, NGF
4chloramphenicol45 3 51 1112.6TP73, NGF
5actinomycin d459.6TP73, NGF
6propentofylline459.5NGF, GFAP
7silicone459.4GFAP, NGF
86-hydroxydopamine459.4NGF, GFAP
9mptp459.4NGF, GFAP
10neomycin459.4GFAP, NGF
11theophylline45 29 24 1112.4NGF, GFAP
12ganglioside459.4NGF, GFAP
13dbc-amp459.4NGF, GFAP
14morphine45 51 29 1112.4NGF, GFAP
15cytarabine45 51 1111.4NGF, GFAP
16cocaine45 1110.4NGF, GFAP
17choline45 24 1111.4GFAP, NGF
18paraffin459.4GFAP, TP73
19quercetin45 61 24 1112.4NGF, GFAP
20matrigel459.3GFAP, NGF
21nmda45 2910.3NGF, GFAP
22acetylcholine45 51 29 24 1113.3NGF, GFAP
23pd 98,059459.3GFAP, NGF
24forskolin45 51 1111.3NGF, GFAP
25genistein45 29 61 3 24 1114.2NGF, GFAP
26glutamine459.2GFAP, NGF
27cisplatin45 51 61 1112.2TP73, GFAP
28dopamine45 29 24 1112.2NGF, GFAP
29thymidine45 2410.1GFAP, NGF
30creatinine459.0NGF, GFAP
31cycloheximide459.0NGF, GFAP
32tetracycline45 119.9TP73, NGF, GFAP
33adenylate458.9GFAP, NGF
34vegf458.9GFAP, NGF, TP73
35arginine458.9GFAP, NGF, TP73
36threonine458.9TP73, NGF, GFAP
37retinoic acid45 249.9GFAP, NGF, TP73
38tyrosine458.8GFAP, NGF, TP73
39cyclic amp45 249.7NGF, GFAP

GO Terms for genes affiliated with Ependymoblastoma

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16Gene Ontology
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Biological processes related to Ependymoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:0069549.3TP73, NGF
2negative regulation of neuron apoptotic processGO:0435249.2TP73, NGF
3positive regulation of apoptotic processGO:0430659.0TP73, NGF

Products for genes affiliated with Ependymoblastoma

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Sources for Ependymoblastoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet