MCID: EPN002
MIFTS: 54

Ependymoma malady

Neuronal, Cancer, Genetic categories

Summaries for Ependymoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Ependymoma is a tumor that arises from the ependyma, a tissue of the central nervous system. Usually, in... more...

MalaCards: Ependymoma, also known as papillary ependymoma, is related to myxopapillary ependymoma and anaplastic ependymoma. An important gene associated with Ependymoma is GFAP (glial fibrillary acidic protein), and among its related pathways are Rho Family GTPases and Neuroscience. The drug carmustine and the compounds paraffin and progesterone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and cortex, and related mouse phenotypes are mortality/aging and digestive/alimentary.

Aliases & Classifications for Ependymoma

Sources:
43NIH Rare Diseases, 61UMLS, 45Novoseek, 49Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
ependymoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

ependymoma 43 45 49 61
papillary ependymoma 43 61
tanycytic ependymoma 43 61
cellular ependymoma 43 61
clear cell ependymoma 43
ependymoma, familial 43


Related Diseases for Ependymoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the malignant ependymoma family:

malignant adult ependymoma benign ependymoma
ependymoma

Diseases related to Ependymoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1myxopapillary ependymoma31.4S100B, GFAP
2anaplastic ependymoma31.2PTEN, GFAP, MUC1, NF2, MDM2, S100B
3spinal cord ependymoma31.1NF2, EPHB3, HOXB13
4clear cell ependymoma30.9VIM, MUC1
5tanycytic ependymoma30.9NF2, GFAP
6papillary ependymoma30.6S100B, SYP, GFAP
7astrocytoma30.6CT49, S100B, VIM, MGMT, MDM2, PTEN
8choroid plexus papilloma30.3GFAP
9neurofibromatosis30.3S100B, MEN1, NF2
10gliosarcoma30.1GFAP, PTEN
11paraganglioma30.0S100B, MEN1, NCAM1, SYP, GFAP
12pilocytic astrocytoma30.0S100B, MGMT, SYP, GFAP, PTEN
13teratoma30.0GFAP
14adenocarcinoma29.8VIM, CT49, MGMT, MDM2, MEN1, EGFR
15anaplastic astrocytoma29.8MGMT, MDM2, EGFR, MKI67, GFAP, PTEN
16anaplastic oligodendroglioma29.8MGMT, MDM2, EGFR, GFAP, PTEN
17bone carcinoma29.8CT49, MDM2, EZR
18astroblastoma29.8GFAP, VIM
19ganglioglioma29.8GFAP, SYP, S100B
20medulloepithelioma29.8SYP
21pediatric ependymoma10.7
22brain ependymoma10.5
23pediatric infratentorial ependymoma10.3
24pediatric supratentorial ependymoma10.3
25cellular ependymoma10.3
26siderosis10.3
27subependymoma10.3
28syringomyelia10.2
29mixed astrocytoma-ependymoma10.2
30benign ependymoma10.2
31back pain10.2
32superficial siderosis10.2
33brain stem ependymoma10.2
34adult spinal cord ependymoma10.2
35headache10.2
36adult brain ependymoma10.1
37mixed astrocytoma-ependymoma-oligodendroglioma10.1
38malignant adult ependymoma10.1
39childhood medulloblastoma10.1
40cauda equina syndrome10.0
41brain glioma10.0
42spinal cancer10.0
43syringobulbia10.0
44multiple endocrine neoplasia10.0
45glioma somatic10.0
46low grade ependymoma10.0
47angiocentric glioma10.0
48meningioma10.0PTEN, GFAP, EZR, MUC1, MKI67, NF2
49melanoma10.0VIM, S100B, CT49, MGMT, MDM2, NF2
50squamous cell carcinoma10.0VIM, CT49, MGMT, MDM2, EGFR, SYP

Graphical network of the top 20 diseases related to Ependymoma:



Diseases related to ependymoma

Clinical Features for Ependymoma

Drugs & Therapeutics for Ependymoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Ependymoma

Drug clinical trials:

Search ClinicalTrials for Ependymoma

Search NIH Clinical Center for Ependymoma

Search CenterWatch for Ependymoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Ependymoma

Anatomical Context for Ependymoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Ependymoma:

33
Lymph node, Brain, Cortex, Cerebellum, Retina, Spinal cord, Liver, Lung, Skin, Ovary, Prostate, T cells, B cells, Endothelial, Temporal lobe, Olfactory bulb, Medulla oblongata, Pineal, Pituitary

Animal Models for Ependymoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Ependymoma

Sources:
51PubMed
See all sources

Articles related to Ependymoma:

(show top 50)    (show all 755)
idTitleAuthorsYear
1
Treatment of Ovarian Anaplastic Ependymoma by an Aromatase Inhibitor. (24413241)
2014
2
Tanycytic ependymoma of the filum terminale associated with multiple endocrine neoplasia type 1: first reported case. (23562332)
2013
3
Resection of filum terminale ependymoma. (23417748)
2013
4
Outcome of infants and young children with newly diagnosed ependymoma treated on the "Head Start" III prospective clinical trial. (23508296)
2013
5
Cytopathologic characteristics and differential diagnostic considerations of osteolytic myxopapillary ependymoma. (23913845)
2013
6
Fine needle aspiration cytology and immunocytochemistry of myxopapillary ependymoma. (22175883)
2013
7
Ependymoma in children: molecular considerations and therapeutic insights. (23615979)
2013
8
Survival benefit for pediatric patients with recurrent ependymoma treated with reirradiation. (22245198)
2012
9
Multiple sclerosis coexisting with spinal cord ependymoma: a case report. (23126220)
2012
10
Clinical, histological, and genetic features of fourth ventricle ependymoma in the elderly. Case report. (22976148)
2012
11
A 5-year investigation of children's adaptive functioning following conformal radiation therapy for localized ependymoma. (22541967)
2012
12
Anaplastic clear cell ependymoma of the conus medullaris and cauda equina in a 3-year-old child. (22009009)
2012
13
Gamma knife surgery-induced ependymoma after the treatment of meningioma - a case report. (22773518)
2012
14
Holocord ependymoma. (22437304)
2012
15
Myxopapillary ependymoma of the cerebellopontine angle: retrograde metastasis or primary tumour? (20707687)
2011
16
Papillary ependymoma of the lateral ventricle: a rare low-grade variant of an uncommon neoplasm in the adult. (22295324)
2011
17
Intraparenchymal clear cell ependymoma. (21713151)
2011
18
Intensity modulated radiation therapy or stereotactic fractionated radiotherapy for infratentorial ependymoma in children: a multicentric study. (20725849)
2011
19
Sudden intraaqueductal dislocation of a third ventricle ependymoma causing acute decompensation of hydrocephalus. (21806356)
2011
20
Infant ependymoma in a 10-year AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) experience with omitted or deferred radiotherapy. (20646868)
2011
21
Exophytic ependymoma of the thoracic spine. (21742501)
2011
22
Surgical technique and outcomes in the treatment of spinal cord ependymomas: part II: myxopapillary ependymoma. (21099714)
2011
23
Molecular staging of intracranial ependymoma in children and adults. (20516456)
2010
24
A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo. (20511191)
2010
25
Evolution of neurological impairment in pediatric infratentorial ependymoma patients. (19330288)
2009
26
Bevacizumab for recurrent ependymoma. (19917990)
2009
27
Recurrent paediatric supratentorial extraventricular ependymoma associated with genetic mutation at exon 4 of p53 gene. (18695856)
2008
28
O6-Methylguanine-DNA-methyltransferase in recurring anaplastic ependymomas: PCR and immunohistochemistry. (18467255)
2008
29
Fourth ventricle ependymoma in father and son. (17952721)
2008
30
Acute paraparesis from hemorrhagic spinal ependymoma: diagnostic dilemma and surgical management. Report of two cases and review of the literature. (18074691)
2007
31
The role of Gamma Knife Radiosurgery in the management of unresectable gross disease or gross residual disease after surgery in ependymoma. (16557349)
2006
32
Methylation of RASSF1A and TRAIL pathway-related genes is frequent in childhood intracranial ependymomas and benign choroid plexus papilloma. (16616114)
2006
33
Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. (16215459)
2005
34
Supratentorial malignant ependymoma in childhood: 16 years without relapse after hemispherectomy. (15095106)
2005
35
Positional and sleep dyspnoea due to posterior exophytic ependymoma of the medulla oblongata. (15897502)
2005
36
Neuroendoscopic resection of posterior third ventricular ependymoma. Case report. (16048289)
2005
37
Minimally invasive management of ependymoma of the aqueduct of Sylvius: therapeutic considerations and management. (16432779)
2005
38
Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma. (16051033)
2005
39
Re: B. Beuthien-Baumann, et al. Differentiation between recurrent tumor and radiation necrosis in a child with anaplastic ependymoma after chemotherapy and radiation therapy. Strahlenther Onkol 2003;179:819-22. (15057436)
2004
40
Supratentorial tanycytic ependymoma. (15519882)
2004
41
Myxopapillary ependymoma with anaplastic features. (14516321)
2003
42
Intraosseous sacral myxopapillary ependymoma and the differential diagnosis of sacral tumors. (11462306)
2001
43
Surgical outcome of intramedullary spinal cord ependymoma. (10352743)
1999
44
Frequent type 2 neurofibromatosis gene transcript mutations in sporadic intramedullary spinal cord ependymomas. (8805149)
1996
45
Subcutaneous sacrococcygeal myxopapillary ependymoma. A case report. (8018424)
1994
46
Myxopapillary ependymoma. Results of nucleolar organizing region staining. (8490841)
1993
47
MRI of concurrent spinal meningioma, ependymoma, and syringomyelia. (1629434)
1992
48
Myxopapillary ependymoma with extensive sacral destruction: CT and MR findings. (1729299)
1992
49
Myxopapillary ependymoma of the lateral ventricle. A study on the mechanism of its stromal myxoid change. (6359815)
1983
50
Malignant ependymoma in a dog. (14497569)
1962

Genetic Variations for Ependymoma

Expression for genes affiliated with Ependymoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Ependymoma

Search GEO for disease gene expression data for Ependymoma.

Pathways for genes affiliated with Ependymoma

Sources:
52QIAGEN, 4Cell Signaling Technology, 54Reactome, 30KEGG, 12EMD Millipore, 56SinoBiological, 38NCBI BioSystems Database, 53R&D Systems
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Compounds for genes affiliated with Ependymoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Ependymoma according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1paraffin4511.2PTEN, GFAP, EZR, SYP, NCAM1, EGFR
2progesterone45 60 29 11 2415.2MGMT, S100B, VIM, CT49, MDM2, EGFR
3serine4511.2MEN1, EGFR, NCAM1, SYP, CT49, EZR
4vegf4511.1MKI67, MEN1, NCAM1, EGFR, MUC1, MDM2
5tyrosine4511.1MUC1, MKI67, EPHB3, NF2, SYP, MEN1
6testosterone45 60 11 2414.1SYP, MUC1, GFAP, PTEN, CT49, EGFR
7cysteine4511.1MGMT, MDM2, NCAM1, NF2, MUC1, GFAP
8retinoic acid45 2412.1S100B, VIM, CT49, MGMT, EGFR, NCAM1
9hematoxylin4511.1NCAM1, PTEN, MKI67, VIM, GFAP, SYP
10agar4511.0NF2, EGFR, CT49, VIM, GFAP, MUC1
11glycogen45 2412.0S100B, MDM2, SYP, MKI67, MUC1, GFAP
12formaldehyde45 2412.0MUC1, S100B, GFAP, SYP, VIM, MKI67
13ethanol45 50 11 2414.0NCAM1, SYP, MKI67, MUC1, EZR, GFAP
14s 1004511.0VIM, S100B, GFAP, MUC1, SYP
15estradiol45 11 2413.0PTEN, GFAP, MUC1, MKI67, SYP, MDM2
16reticulin4511.0GFAP, VIM, MUC1, S100B, SYP
17threonine4511.0PTEN, GFAP, S100B, MDM2, NCAM1, NF2
18genistein45 29 60 2 11 2416.0MGMT, PTEN, GFAP, EZR, VIM, MDM2
19cisplatin45 50 60 1114.0PTEN, GFAP, MUC1, MKI67, SYP, EGFR
20thymidine45 2412.0MEN1, CT49, MDM2, S100B, MKI67, MUC1
21cyclic amp45 2412.0VIM, PTEN, GFAP, EZR, MUC1, SYP
22paclitaxel45 50 1113.0S100B, MDM2, EGFR, GFAP, PTEN
23eosin4511.0GFAP, VIM, MUC1, S100B
24calcium45 50 11 2414.0S100B, MEN1, NCAM1, CD207, MUC1, SYP
25forskolin45 50 1113.0CT49, EZR, MUC1, SYP, S100B, VIM
26estrogen4510.9GFAP
27doxorubicin45 50 1112.9EGFR, NCAM1, PTEN, MDM2, VIM, MGMT
28mucicarmine4510.9MUC1, SYP, S100B, VIM
29vincristine45 50 1112.9NCAM1, MGMT, VIM, MKI67
30dbc-amp4510.9NCAM1, S100B, GFAP, SYP, VIM
315fluorouracil4510.9PTEN, EGFR, MUC1, MGMT, MDM2, MKI67
32nitric oxide45 11 2412.9S100B, MGMT, MDM2, MUC1, PTEN, MKI67
33b 7234510.9S100B, MUC1, SYP, VIM
34alanine4510.9VIM, CT49, MDM2, NCAM1, EZR, GFAP
35dexamethasone45 50 29 1113.9S100B, MGMT, MDM2, GFAP
36lipid4510.9NCAM1, VIM, SYP, MKI67, EZR, GFAP
37thymidylate4510.9VIM, MKI67, MDM2, EGFR, MGMT
38etoposide45 50 60 1113.8MDM2, VIM, S100B
39dutp4510.8GFAP, MKI67, SYP, MDM2
40bromodeoxyuridine4510.8GFAP, MKI67, S100B, NCAM1, VIM
41deoxyribonucleic acid4510.7PTEN, MGMT, CT49, NF2
42streptozotocin4510.7SYP, GFAP
435-aza-2deoxycytidine4510.7MGMT, PTEN, MDM2, CT49, VIM
44trastuzumab45 50 1112.7EGFR, MDM2, MUC1, PTEN
45proline4510.7MKI67, MDM2, VIM, MGMT, S100B, EZR
46methotrexate45 50 1112.6VIM, MUC1, MKI67, MDM2, MGMT
47ganglioside4510.6GFAP, NCAM1, SYP, VIM
48gefitinib45 50 1112.5VIM, MDM2, EGFR, PTEN
49irinotecan45 50 1112.4MGMT, MDM2, EGFR, MKI67
50lactate4510.3GFAP, VIM, S100B, NCAM1, MKI67, MGMT

GO Terms for genes affiliated with Ependymoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.7PTEN, S100B, SCHIP1, MDM2, MEN1, EGFR

Biological processes related to Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:06029110.6PTEN, GFAP, S100B
2Bergmann glial cell differentiationGO:06002010.6GFAP, VIM
3intermediate filament organizationGO:04510910.5GFAP, VIM
4dendritic spine morphogenesisGO:06099710.5EPHB3, PTEN
5astrocyte developmentGO:01400210.4GFAP, VIM
6negative regulation of organ growthGO:04662110.2PTEN, MEN1

Molecular functions related to Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.6CBY1, SYP, NCAM1, EGFR, MDM2, SCHIP1

Products for genes affiliated with Ependymoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ependymoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet