MCID: EPN002
MIFTS: 44

Ependymoma malady

Neuronal diseases, Cancer diseases, Genetic diseases categories

Summaries for Ependymoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ependymoma is a tumor that arises from the ependyma, a tissue of the central nervous system. Usually, in... more...

MalaCards: Ependymoma, also known as papillary ependymoma, is related to myxopapillary ependymoma and spinal cord ependymoma. An important gene associated with Ependymoma is GFAP (glial fibrillary acidic protein), and among its related pathways are Rho Family GTPases and Neuroscience. The drug carmustine and the compounds paraffin and progesterone have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and digestive/alimentary.

Aliases & Classifications for Ependymoma

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42NIH Rare Diseases, 60UMLS, 44Novoseek, 48Orphanet, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
ependymoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

ependymoma 42 44 48 60
papillary ependymoma 42 60
tanycytic ependymoma 42 60
cellular ependymoma 42 60
clear cell ependymoma 42
ependymoma, familial 42


External Ids:

SNOMED-CT via Orphanet57 443643007

Related Diseases for Ependymoma

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17GeneCards, 18GeneDecks
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Diseases in the Malignant Ependymoma family:

Malignant Adult Ependymoma Benign Ependymoma
ependymoma

Diseases related to Ependymoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1myxopapillary ependymoma31.4S100B, GFAP
2spinal cord ependymoma31.1NF2, EPHB3, HOXB13
3clear cell ependymoma30.9VIM, MUC1
4tanycytic ependymoma30.8NF2, GFAP
5malignant ependymoma30.8NF2, GFAP
6anaplastic ependymoma30.6PTEN, GFAP, MUC1, NF2, MDM2, S100B
7papillary ependymoma30.6S100B, SYP, GFAP
8astrocytoma30.6CT49, S100B, VIM, MGMT, MDM2, PTEN
9meningioma30.5PTEN, GFAP, EZR, MUC1, MKI67, NF2
10medulloblastoma30.5MGMT, CT49, S100B, NCAM1, SYP, GFAP
11oligodendroglioma30.4PTEN, GFAP, EGFR, MGMT
12papilloma30.3CT49
13choroid plexus papilloma30.3GFAP
14neurofibromatosis30.3S100B, MEN1, NF2
15hemangioblastoma30.1S100B, GFAP, EZR, MUC1, SYP
16chordoma30.0GFAP, MUC1, NCAM1, S100B, VIM
17paraganglioma30.0S100B, MEN1, NCAM1, SYP, GFAP
18gliosarcoma30.0GFAP, PTEN
19lipoma30.0PTEN, MEN1, MDM2
20adenocarcinoma29.7VIM, CT49, MGMT, MDM2, MEN1, EGFR
21sarcoma29.7VIM, S100B, MDM2, NF2, MKI67, MUC1
22malignant glioma29.7MGMT, MDM2, EGFR, SYP, NF2, EZR
23neurofibroma29.7VIM, S100B, SYP, NF2, MUC1
24chondrosarcoma29.7VIM, S100B, MDM2, MUC1
25neuroendocrine tumor29.7MEN1, NCAM1, SYP, MKI67
26astroblastoma29.7GFAP, VIM
27herpes simplex29.7NF2
28ganglioglioma29.7GFAP, SYP, S100B
29medulloepithelioma29.7SYP
30pediatric ependymoma10.7
31cervicitis10.4
32brain ependymoma10.4
33choroiditis10.3
34pediatric infratentorial ependymoma10.3
35hydrocephalus10.3
36cerebritis10.3
37pediatric supratentorial ependymoma10.2
38cellular ependymoma10.2
39siderosis10.2
40syringomyelia10.2
41benign ependymoma10.2
42brain stem ependymoma10.1
43adult spinal cord ependymoma10.1
44adult brain ependymoma10.1
45mixed astrocytoma-ependymoma10.1
46mixed astrocytoma-ependymoma-oligodendroglioma10.1
47malignant adult ependymoma10.1
48childhood medulloblastoma10.1
49communicating hydrocephalus10.1
50mediastinitis10.1

Graphical network of the top 20 diseases related to Ependymoma:



Diseases related to ependymoma

Clinical Features for Ependymoma

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Drugs & Therapeutics for Ependymoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Ependymoma

Search CenterWatch for Ependymoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Ependymoma

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Anatomical Context for Ependymoma

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Animal Models for Ependymoma or affiliated genes

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36MGI
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Publications for Ependymoma

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Genetic Variations for Ependymoma

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Expression for genes affiliated with Ependymoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ependymoma

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Pathways for genes affiliated with Ependymoma

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Sources:
51QIAGEN, 4Cell Signaling Technology, 53Reactome, 29KEGG, 12EMD Millipore, 55SinoBiological, 37NCBI BioSystems Database, 52R&D Systems
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Compounds for genes affiliated with Ependymoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Ependymoma according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1paraffin4411.2PTEN, GFAP, EZR, SYP, NCAM1, EGFR
2progesterone44 59 28 11 2415.2MGMT, S100B, VIM, CT49, MDM2, EGFR
3serine4411.2MEN1, EGFR, NCAM1, SYP, CT49, EZR
4vegf4411.1MKI67, MEN1, NCAM1, EGFR, MUC1, MDM2
5tyrosine4411.1MUC1, MKI67, EPHB3, NF2, SYP, MEN1
6testosterone44 59 11 2414.1SYP, MUC1, GFAP, PTEN, CT49, EGFR
7cysteine4411.1MGMT, MDM2, NCAM1, NF2, MUC1, GFAP
8retinoic acid44 2412.1S100B, VIM, CT49, MGMT, EGFR, NCAM1
9hematoxylin4411.1NCAM1, PTEN, MKI67, VIM, GFAP, SYP
10agar4411.0NF2, EGFR, CT49, VIM, GFAP, MUC1
11glycogen44 2412.0S100B, MDM2, SYP, MKI67, MUC1, GFAP
12formaldehyde44 2412.0MUC1, S100B, GFAP, SYP, VIM, MKI67
13ethanol44 49 11 2414.0NCAM1, SYP, MKI67, MUC1, EZR, GFAP
14s 1004411.0VIM, S100B, GFAP, MUC1, SYP
15estradiol44 11 2413.0PTEN, GFAP, MUC1, MKI67, SYP, MDM2
16reticulin4411.0GFAP, VIM, MUC1, S100B, SYP
17threonine4411.0PTEN, GFAP, S100B, MDM2, NCAM1, NF2
18genistein44 28 59 2 11 2416.0MGMT, PTEN, GFAP, EZR, VIM, MDM2
19cisplatin44 49 59 1114.0PTEN, GFAP, MUC1, MKI67, SYP, EGFR
20thymidine44 2412.0MEN1, CT49, MDM2, S100B, MKI67, MUC1
21cyclic amp44 2412.0VIM, PTEN, GFAP, EZR, MUC1, SYP
22paclitaxel44 49 1113.0S100B, MDM2, EGFR, GFAP, PTEN
23eosin4411.0GFAP, VIM, MUC1, S100B
24calcium44 49 11 2414.0S100B, MEN1, NCAM1, CD207, MUC1, SYP
25forskolin44 49 1113.0CT49, EZR, MUC1, SYP, S100B, VIM
26estrogen4410.9GFAP
27doxorubicin44 49 1112.9EGFR, NCAM1, PTEN, MDM2, VIM, MGMT
28mucicarmine4410.9MUC1, SYP, S100B, VIM
29vincristine44 49 1112.9NCAM1, MGMT, VIM, MKI67
30dbc-amp4410.9NCAM1, S100B, GFAP, SYP, VIM
315fluorouracil4410.9PTEN, EGFR, MUC1, MGMT, MDM2, MKI67
32nitric oxide44 11 2412.9S100B, MGMT, MDM2, MUC1, PTEN, MKI67
33b 7234410.9S100B, MUC1, SYP, VIM
34alanine4410.9VIM, CT49, MDM2, NCAM1, EZR, GFAP
35dexamethasone44 49 28 1113.9S100B, MGMT, MDM2, GFAP
36lipid4410.9NCAM1, VIM, SYP, MKI67, EZR, GFAP
37thymidylate4410.9VIM, MKI67, MDM2, EGFR, MGMT
38etoposide44 49 59 1113.8MDM2, VIM, S100B
39dutp4410.8GFAP, MKI67, SYP, MDM2
40bromodeoxyuridine4410.8GFAP, MKI67, S100B, NCAM1, VIM
41deoxyribonucleic acid4410.7PTEN, MGMT, CT49, NF2
42streptozotocin4410.7SYP, GFAP
435-aza-2deoxycytidine4410.7MGMT, PTEN, MDM2, CT49, VIM
44trastuzumab44 49 1112.7EGFR, MDM2, MUC1, PTEN
45proline4410.7MKI67, MDM2, VIM, MGMT, S100B, EZR
46methotrexate44 49 1112.6VIM, MUC1, MKI67, MDM2, MGMT
47ganglioside4410.6GFAP, NCAM1, SYP, VIM
48gefitinib44 49 1112.5VIM, MDM2, EGFR, PTEN
49irinotecan44 49 1112.4MGMT, MDM2, EGFR, MKI67
50lactate4410.3GFAP, VIM, S100B, NCAM1, MKI67, MGMT

GO Terms for genes affiliated with Ependymoma

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16Gene Ontology
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Cellular components related to Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.7PTEN, S100B, SCHIP1, MDM2, MEN1, EGFR

Biological processes related to Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:06029110.6PTEN, GFAP, S100B
2Bergmann glial cell differentiationGO:06002010.6GFAP, VIM
3intermediate filament organizationGO:04510910.5GFAP, VIM
4dendritic spine morphogenesisGO:06099710.5EPHB3, PTEN
5astrocyte developmentGO:01400210.4GFAP, VIM
6negative regulation of organ growthGO:04662110.2PTEN, MEN1

Molecular functions related to Ependymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.6CBY1, SYP, NCAM1, EGFR, MDM2, SCHIP1

Products for genes affiliated with Ependymoma

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  • Antibodies
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  • Antibodies

Sources for Ependymoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet