Ependymoma malady

Wikipedia: Ependymoma is a tumor that arises from the ependyma, a tissue of the central nervous system. Usually, in...⁴⁴ more...

MalaCards: Ependymoma, also known as clear cell ependymoma (histologic variant), is related to myxopapillary ependymoma and anaplastic ependymoma. An important gene associated with Ependymoma is GFAP (glial fibrillary acidic protein), and among its related pathways are Pancreatic cancer and Neuroscience. The drug carmustine and the compounds egcg and vincristine have been mentioned in the context of this disorder. Affiliated tissues include brain, retina and spinal cord, and related mouse phenotypes are craniofacial and respiratory system.

ependymoma 30 8 32 43 clear cell ependymoma (histologic variant) 30 papillary ependymoma (histologic variant) 30

tanycytic ependymoma (histologic variant) 30 cellular ependymoma (histologic variant) 30 ependymoma, familial 30

Diseases related to ependymoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 973)

id	Related Disease	Score	Top Affiliating Genes
1	myxopapillary ependymoma	34.4	NCAM1, VIM, LGALS3, MUC1, S100B, CA2
2	anaplastic ependymoma	33.8	MUC1, S100B, MGMT, MDM2, PTEN, NF2
3	pediatric ependymoma	33.5	SCHIP1, MMP14, MEN1, MAPRE1, CBY1, EZR
4	papillary ependymoma	31.9	S100B, GFAP, SYP
5	oligodendroglioma	30.6	CDKN2B, CDKN2A, MGMT, TP73, PTEN, EGFR
6	choroid plexus papilloma	30.2	MUC1, S100B, GFAP, TTR, TAG, SYP
7	subependymoma	29.9	HBG2, TSC2, NES
8	neurofibromatosis	28.5	EZR, NF1, NF2, EPB41L3
9	chordoid meningioma	27.9	NCAM1, VIM, VEGFA, LGALS3, MUC1, S100B
10	chordoma	26.1	NCAM1, VIM, VEGFA, LGALS3, MUC1, S100B
11	choroiditis	25.1	NCAM1, VTN, VIM, VEGFA, RARB, RASSF1
12	papilloma	24.4	RB1, VIM, BRCA2, VEGFA, RARB, RASSF1
13	neuroectodermal tumors	24.2	NCAM1, RB1, VIM, RASSF1, MUC1, S100B
14	renal cell carcinoma	23.7	VIM, VEGFA, RARB, RASSF1, BIRC5, MUC1
15	meningioma	23.6	NCAM1, NCL, RB1, VIM, BRCA2, VEGFA
16	medulloblastoma	23.5	NCAM1, RB1, VIM, BRCA2, RASSF1, BIRC5
17	astrocytoma	18.3	NCAM1, VTN, RB1, VIM, BRCA2, VEGFA
18	ovarian carcinoma	18.2	VTN, RB1, RBP4, VIM, BRCA2, VEGFA
19	hypoxia	18.1	VTN, RB1, VEGFA, BNIP3, BIRC5, LGALS3
20	malignant glioma	17.9	VTN, RB1, VIM, VEGFA, BNIP3, BIRC5
21	neuronitis	15.5	NCAM1, NCL, RB1, VIM, BRCA2, VEGFA
22	perineurioma	14.2	NCAM1, VIM, MUC1, S100B, NF2, PDGFRA
23	cellular schwannoma	14.1	VIM, S100B, NF1, NF2, GFAP
24	glomus tumor	14.1	VIM, MUC1, S100B, CDKN2B, NGFR, SYP
25	spindle cell sarcoma	14.1	VIM, MUC1, S100B, KRT7
26	pineocytoma	14.1	S100B, ENO2, GFAP, TAG, SYP
27	secretory meningioma	14.1	VIM, MUC1, NF2, KRT7
28	choroid plexus carcinoma	14.1	S100B, GFAP, TTR, TAG
29	clear cell meningioma	14.1	VIM, MUC1, MKI67
30	ovarian sex cord tumors	14.1	VIM, MUC1, ENO2, KRT7, SYP
31	parachordoma	14.1	VIM, MUC1, S100B, KRT7, KRT20
32	syringoma	14.1	VIM, MUC1, S100B, KRT20, GFAP
33	fibrous meningioma	14.1	MUC1, S100B, NF2
34	meninges hemangiopericytoma	14.1	NCAM1, RB1, VIM, MUC1, NF2, EPB41L3
35	polymorphous low-grade adenocarcinoma	14.1	VIM, LGALS3, MUC1, S100B
36	chordoid glioma	14.1	VIM, MUC1, S100B, CDK4, KRT7, GFAP
37	anaplastic ganglioglioma	14.1	S100B, GFAP, NES
38	congenital epulis	14.1	VIM, S100B, ENO2
39	mixed glioma	14.1	VIM, PDGFRA, GFAP
40	chondroid chordoma	14.0	VIM, MUC1, S100B
41	bednar's tumor	14.0	VIM, S100B, ENO2, PDGFB
42	congenital granular cell tumor	14.0	VIM, S100B, ENO2
43	pineal gland cancer	14.0	ENO2, GFAP, SYP
44	neurilemmoma	14.0	VIM, SMARCB1, NGFR, NF1, NF2, GFAP
45	gastric small cell carcinoma	14.0	NCAM1, ENO2, SYP
46	subependymal giant cell astrocytoma	14.0	S100B, TSC1, TSC2, SYP
47	mesenchymal chondrosarcoma	14.0	VIM, MUC1, S100B, SMARCB1, GFAP, SOX9
48	sex cord-gonadal stromal tumor	14.0	VIM, MUC1, S100B, WT1, KRT7
49	acoustic neuroma	14.0	EZR, NGFR, NF1, NF2, GDNF
50	sertoli-leydig cell tumor	14.0	VIM, MUC1, ENO2, WT1, KRT7, SYP

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

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MalaCards organs/tissues related to ependymoma:

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MGI Mouse Phenotypes related to ependymoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	10.1	NF1, NOTCH1, TP73, MEN1, MIB1, SCHIP1
2	respiratory system phenotype	MP:0005388	9.9	SOX9, SOX4, PDGFB, NF2, NF1, GLS
3	endocrine/exocrine gland phenotype	MP:0005379	9.0	HOXB13, CA9, IFNG, FANCL, IL2, MEN1
4	other phenotype	MP:0005395	8.8	CDKN2A, CSF2, SOD2, PDGFRA, NF1, RARB
5	renal/urinary system phenotype	MP:0005367	8.7	NF2, NF1, NGFR, NOTCH1, CTNNB1, DAPK1
6	adipose tissue phenotype	MP:0005375	8.6	ADCYAP1, SCG5, APC, CBY1, TP53, RB1
7	hematopoietic system phenotype	MP:0005397	8.6	NF1, NOTCH1, PLEK, SMARCB1, NTRK1, TERC
8	pigmentation phenotype	MP:0001186	8.4	NOTCH1, RB1, CDKN2A, MDM2, APC, PDGFRA
9	nervous system phenotype	MP:0003631	8.2	MTHFR, LGALS3, SCG5, PAX5, RB1, GDNF
10	limbs/digits/tail phenotype	MP:0005371	8.1	MIB1, MMP14, S1PR3, MTHFR, RARB, VEGFA
11	liver/biliary system phenotype	MP:0005370	7.9	EPB41, VEGFA, SCG5, MEN1, ADCYAP1, TSC2
12	no phenotypic analysis	MP:0003012	7.8	CTNNB1, ARVCF, PTGS2, SOX9, DCX, SYP
13	integument phenotype	MP:0010771	6.5	CSF2, SOX9, SOX4, HIC1, CBY1, IFNG
14	skeleton phenotype	MP:0005390	6.1	HIF1A, ERBB2, APC, MDM2, MIB1, MMP14
15	normal phenotype	MP:0002873	6.0	EPB41L3, SOX4, IL4, IL10, MIB1, FLT1
16	reproductive system phenotype	MP:0005389	6.0	IL4, IL10, MEN1, FLT1, MMP14, CDKN2B
17	behavior/neurological phenotype	MP:0005386	5.8	IFNG, BRCA2, VIM, RB1, NCAM1, LRIG3
18	growth/size phenotype	MP:0005378	5.2	TSC1, GFAP, HIF1A, HIC1, EGFR, EGF
19	muscle phenotype	MP:0005369	4.7	VIM, RBP4, RB1, GDNF, ADCYAP1, SOX9
20	vision/eye phenotype	MP:0005391	4.0	SMARCB1, CDK4, CDKN2A, MTHFR, MUC1, RARB
21	cardiovascular system phenotype	MP:0005385	3.8	TP73, S1PR3, LDHA, LGALS3, SCHIP1, SCG5
22	embryogenesis phenotype	MP:0005380	INF	ADCYAP1, CSF2, SOX9, SOX4, TGFB2, HIC1
23	immune system phenotype	MP:0005387	INF	EPB41, CSF2, SOX9, SOD2, TP53, CBY1
24	hearing/vestibular/ear phenotype	MP:0005377	INF	CBY1, NGFR, S1PR3, TP73, , CTNNB1
25	tumorigenesis	MP:0002006	INF	EPB41L3, CSF2, SOD2, TSC2, TSC1, TERC
26	digestive/alimentary phenotype	MP:0005381	INF	PTEN, RARB, VEGFA, BRCA2, RB1, SCHIP1
27	homeostasis/metabolism phenotype	MP:0005376	INF	MIB1, BNIP3, VEGFA, BRCA2, VIM, RBP4
28	mortality/aging	MP:0010768	INF	NES, CSF2, SOX9, SOX4, PSIP1, DCX
29	cellular phenotype	MP:0005384	INF	PTEN, IL10, MEN1, MIB1, FLT1, MMP14

Articles related to ependymoma:

(show top 50)    (show all 90)

id	Title	Authors	Year	Affiliating Genes
1	Epidermal growth factor receptor and caveolin-1 coexp ression identifies adult supratentorial ependymomas with rapid unfavorable outc omes. (21059755)	Senetta R.... Cassoni P.	2011	EGFR
2	Multiple intradural-extramedullary ependymomas: prove n dissemination by genetic analysis. (20433294)	Vural M.... Adapinar B.	2010	EGFR
3	EDG3 and SHC3 on chromosome 9q22 are co-amplified in human ependymomas. (19748727)	Magrassi L.... Arbustini E.	2010	SHC3, S1PR3
4	Extraspinal ependymoma of the broad ligament. (20403052)	Matsuyama A.... Hashimoto H.	2010	GFAP
5	Immunohistochemical comparison of chordoma with chond rosarcoma, myxopapillary ependymoma, and chordoid meningioma. (19521276)	Cho H.Y.... Zhai Q.J.	2009	S100B, NCAM1, MUC1
6	Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas. (19289631)	Puget S.... Vassal G.	2009	NOTCH1
7	Real-time quantitative PCR analysis of pediatric ependymomas identifies novel candidate genes including TPR at 1q25 and CHIBBY at 22q12-q13. (18663750)	Karakoula K.... Warr T.J.	2008	TPR, CBY1
8	EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts. (18386816)	Geoerger B.... Vassal G.	2008	EGFR
9	Decreased expression of antioxidant enzymes is associated with aggressive features in ependymomas. (18682894)	JAorvelAo S.... Haapasalo H.	2008	SOD2, PRDX5, TXN
10	Differential expression and prognostic significance of SOX genes in pediatric medulloblastoma and ependymoma identified by microarray analysis. (18577562)	de Bont J.M.... Pieters R.	2008	SOX9, SOX4
11	Immunohistochemical study of CD99 and EMA expression in ependymomas. (18382710)	Mahfouz S.... El-Sheikh S.	2008	MUC1
12	Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma. (18701711)	Ridley L.... Grundy R.G.	2008	TERT, BIRC5, NCL
13	Ependymomas of the central nervous system and adult extra-axial ependymomas are morphologically and immunohistochemically distinct--a comparative study with assessment of ovarian carcinomas for expression of glial fibrillary acidic protein. (18360284)	Idowu M.O.... Soslow R.A.	2008	MUC1, WT1, KRT18
14	Genetic abnormalities and CNS tumors: report of two cases of ependymoma associated with Klinefelter's Syndrome (KS). (17058088)	Garre M.L.... Naselli A.	2007	MTHFR
15	Evaluation of NF2 gene deletion in sporadic schwannomas, meningiomas, and ependymomas by chromogenic in situ hybridization. (17509660)	Begnami M.D.... Quezado M.	2007	NF2
16	p53 Pathway dysfunction in primary childhood ependymomas. (16086408)	Gaspar N.... Vassal G.	2006	MDM2, PAX5
17	APC and CTNNB1 mutations are rare in sporadic ependymomas. (16843107)	Onilude O.E.... Clifford S.C.	2006	APC, CTNNB1
18	Survivin expression in intracranial ependymomas and its correlation with tumor cell proliferation and patient outcome. (16146813)	Preusser M.... Hainfellner J.A.	2005	BIRC5, MKI67
19	Primary glial tumor of the retina with features of myxopapillary ependymoma. (16160486)	Hegyi L.... Roncaroli F.	2005	CA2
20	Immunohistochemical study is helpful for the diagnosis of cerebellar clear cell ependymoma with atypical radiological findings--case report (16277226)	Hayashi T.... Kameyama K.	2005	VIM, MUC1
21	Alterations of protein 4.1 family members in ependymomas: a study of 84 cases. (15731777)	Rajaram V.... Perry A.	2005	NF2, EPB41L3, EPB41
22	Vascularization and expression of hypoxia-related tissue factors in intracranial ependymoma and their impact on patient survival. (15614581)	Preusser M.... Hainfellner J.A.	2005	HIF1A, CA9
23	Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma. (16051033)	Hamilton D.W.... Clifford S.C.	2005	RB1, MGMT, RASSF1
24	Histological spectrum of ependymomas and correlation of p53 and Ki-67 expression with ependymoma grade and subtype. (15318011)	Suri V.S.... Sharma A.	2004	GFAP, SYP
25	Analysis of HIC-1 methylation and transcription in human ependymomas. (15122586)	Waha A.... Waha A.	2004	HIC1
26	Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age. (14578171)	Korshunov A.... Lichter P.	2003	LDHA, MAT2A
27	Sensitivity and specificity of epithelial membrane antigen staining patterns in ependymomas. (12898159)	Hasselblatt M.... Paulus W.	2003	MUC1
28	Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade. (14583779)	Altura R.A.... Boue D.R.	2003	BIRC5
29	Epithelioid ependymoma: a new variant of ependymoma: report of three cases. (12943590)	Kleinman G.M.... Miller D.C.	2003	VIM, MUC1
30	ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease. (12374672)	Gilbertson R.J.... Ellison D.W.	2002	ERBB2
31	Complex cytogenetic abnormalities including telomeric associations and MEN1 mutation in a pediatric ependymoma. (12505253)	Urioste M.... Benitez J.	2002	MEN1
32	Analysis of the NF2 gene in oligodendrogliomas and ependymomas. (11996787)	Alonso M.E.... Rey J.A.	2002	NF2
33	Molecular genetic alterations on chromosomes 11 and 22 in ependymomas. (11275983)	Lamszus K.... Westphal M.	2001	MEN1
34	p14ARF protein (FL-132) immunoreactivity in intracranial ependymomas and its prognostic significance: an analysis of 103 cases. (11585252)	Korshunov A.... Timirgaz V.	2001	MDM2, TP53
35	Receptor-mediated endocytosis of transthyretin by ependymoma cells. (10869517)	Kuchler-Bopp S.... Delaunoy J.P.	2000	TTR, RBP4
36	Fluorescence in situ hybridization determination of 22q12-q13 deletion in two intracerebral ependymomas. (11063814)	Rousseau-Merck M.... Vagner-Capodano A.M.	2000	NF2
37	Evidence for an ependymoma tumour suppressor gene in chromosome region 22pter-22q11.2. (10584875)	Hulsebos T.J.... Tijssen C.C.	1999	NF2
38	Signet-ring cell ependymoma: case report with implications for pathogenesis and differential diagnosis. (10631722)	Vajtai I.... BA^di I.	1999	MUC1
39	Interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-1 receptor type I, IL-1 receptor antagonist, and TGF-beta 1 mRNAs in pediatric astrocytomas, ependymomas, and primitive neuroectodermal tumors. (9565970)	Ilyin S.E.... Plata-Salaman C.R.	1998	IL1B, IL1A, IL1RAPL2
40	Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma. (9669344)	Chan A.S.... Chung L.P.	1998	FLT1, VEGFA
41	Immunohistochemical detection of schwannomin and neurofibromin in vestibular schwannomas, ependymomas and meningiomas. (9100669)	Huynh D.P.... Pulst S.M.	1997	NF1, NF2, SCG5
42	Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas. (9266734)	Wienecke R.... Gutmann D.H.	1997	TSC1, TSC2
43	Expression of telomerase RNA component correlates with the MIB-1 proliferation index in ependymomas. (9329458)	Rushing E.J.... Gazdar A.F.	1997	TERC
44	Molecular studies of an ependymoma-associated constitutional t(1;22)(p22;q11.2). (9465898)	Rhodes C.H.... Mohandas T.K.	1997	ARVCF
45	Frequent type 2 neurofibromatosis gene transcript mutations in sporadic intramedullary spinal cord ependymomas. (8805149)	Birch B.D.... Bruce J.N.	1996	NF2
46	Clear cell variants of intracranial tumors: meningioma and ependymoma. (8867691)	Kakita A.... Ikuta F.	1995	VIM
47	Natural simian virus 40 strains are present in human choroid plexus and ependymoma tumors. (7571441)	Lednicky J.A.... Butel J.S.	1995	TAG
48	Immunohistochemical study for choroid plexus papillomas and ependymomas (1726244)	Kunishio K.... Taguchi K.	1991	S100B, MUC1, GFAP
49	Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma. (1679237)	Metzger A.K.... Cogen P.H.	1991	TP53
50	Intracranial ependymoma and subependymoma: MR manifestations. (2107685)	Spoto G.P.... Solomon M.	1990	HBG2

Genes related to ependymoma according to GeneCards:

(show top 50)    (show all 114)

id	Symbol	Description	Score	GeneCards Section Context
1	GFAP	glial fibrillary acidic protein	11.0	Publications
2	MUC1	mucin 1, cell surface associated	11.0	Publications
3	S100B	S100 calcium binding protein B	11.0	Publications
4	NF2	neurofibromin 2 (merlin)	11.0	Publications
5	VIM	vimentin	11.0	Publications
6	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
7	MEN1	multiple endocrine neoplasia I	11.0	Publications
8	SYP	synaptophysin	11.0	Publications
9	EZR	ezrin	11.0	Publications
10	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
11	NCAM1	neural cell adhesion molecule 1	11.0	Publications
12	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
13	PTEN	phosphatase and tensin homolog	11.0	Publications
14	EGFR	epidermal growth factor receptor	11.0	Publications
15	SCHIP1	schwannomin interacting protein 1	11.0
16	CBY1	chibby homolog 1 (Drosophila)	11.0	Publications
17	CD207	CD207 molecule, langerin	11.0	Expressions
18	MAPRE1	microtubule-associated protein, RP/EB family, member 1	11.0	Publications
19	KRT7	keratin 7	11.0	Publications
20	CA2	carbonic anhydrase II	11.0	Publications
21	TPR	translocated promoter region, nuclear basket protein	11.0	Publications
22	TERC	telomerase RNA component	11.0	Publications
23	NGFR	nerve growth factor receptor	11.0	Publications
24	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
25	PDGFA	platelet-derived growth factor alpha polypeptide	11.0	Publications
26	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
27	DCX	doublecortin	11.0
28	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0
29	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
30	TSC2	tuberous sclerosis 2	11.0	Publications
31	TAG	tumor antigen gene	11.0	Publications
32	NES	nestin	11.0
33	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Publications
34	RB1	retinoblastoma 1	11.0	Publications
35	TTR	transthyretin	11.0	Publications
36	ENO2	enolase 2 (gamma, neuronal)	11.0
37	TP73	tumor protein p73	11.0	Publications
38	DAPK1	death-associated protein kinase 1	11.0	Publications
39	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
40	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0
41	MAP2	microtubule-associated protein 2	11.0
42	NF1	neurofibromin 1	11.0	Publications
43	TPTE2P6	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6	11.0	Publications
44	MAGEH1	melanoma antigen family H, 1	11.0
45	ZMYND10	zinc finger, MYND-type containing 10	11.0	Publications
46	HIC1	hypermethylated in cancer 1	11.0	Publications
47	MAT2A	methionine adenosyltransferase II, alpha	11.0	Publications
48	HOXB13	homeobox B13	11.0
49	SOX4	SRY (sex determining region Y)-box 4	10.9	Publications
50	UFD1L	ubiquitin fusion degradation 1 like (yeast)	10.9	Publications

Pathways related to ependymoma according to GeneDecks:

(show top 50)    (show all 120)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic cancer20	10.7	BRCA2
2	Neuroscience3	10.1	ENO2, MAP2, S100B, CA2, PTGS2, NOTCH1
3	ERK5 Signaling36	9.8	EGFR, TIMP3, TGFB2, PSIP1, PDGFRA, PDGFB
4	Actin-Based Motility by Rho Family GTPases36	9.8	IL2, NGFR, NTRK1
5	14-3-3 Induced Intracellular Signaling36	9.8	PDGFB, PSIP1, TGFB2, TIMP3, TSC2, FLT1
6	Glioblastoma Multiforme36	9.7	PDGFRA, PDGFB, PDGFA, NF2, NF1, PTEN
7	PPAR Pathway36	9.7	TGFB2, PSIP1, IL2, PDGFRA, PDGFB, NGFR
8	Non-small cell lung cancer20	9.5	EGF, CDKN2A, ERBB2, RB1, CDK4, RASSF1
9	eIF2 Pathway36	9.5	NTRK1, PDGFA, PDGFB, PDGFRA, EGF, EGFR
10	Akt Signaling36	9.4	TSC1, PSIP1, CSF2, TGFB2, TIMP3, IL10
11	Telomerase Components in Cell Signaling36	9.4	NTRK1, PSIP1, PDGFA, PDGFB, EGFR, IL2
12	Epithelial Adherens Junctions36	9.4	PTEN, ERBB2, CTNNB1, NOTCH1, PDGFA, PDGFB
13	Nuclear Receptor Activation by Vitamin-A36	9.3	EGFR, EGF, PDGFRA, PDGFB, FLT1, NGFR
14	DHA Signaling36	9.3	PDGFRA, IL1B, PSIP1, PDGFB, EGF, EGFR
15	Rac1 Pathway36	9.2	TIMP3, TGFB2, PDGFA, EGF, PDGFB, NGFR
16	Melanoma20	9.2	CDK4, PDGFA, CDKN2A, MDM2, RB1, EGFR
17	NF-KappaB (p50-p65) Pathway36	9.2	IL1A, FLT1, IL1B, IL2, NGFR, TGFB2
18	Glioma20	9.2	SHC3, RB1, CDKN2A, CDK4, MDM2, PTEN
19	Focal adhesion20	9.2	SHC3, PDGFRA, PDGFB, PDGFA, EGFR, PTEN
20	Activation of PKC through GPCR36	9.2	TIMP3, TGFB2, EGFR, PSIP1, EGF, FLT1
21	NF-KappaB Family Pathway36	9.1	NGFR, TIMP3, EGFR, EGF, PDGFB, PDGFA
22	p70S6K Signaling36	9.1	IL4, PDGFA, IL2, FLT1, NGFR, PDGFB
23	Transcription P53 signaling pathway10	9.1	VEGFA, CDKN2A, TP53
24	JNK Pathway36	9.0	EGF, PSIP1, PDGFRA, PDGFB, IL2, FLT1
25	Prostate cancer20	9.0	EGFR, PDGFA, PDGFB, CTNNB1, EGF, PTEN
26	PTEN Pathway36	9.0	PSIP1, FLT1, IL2, MDM2, TP53, PTEN
27	p53 Mediated Apoptosis36	9.0	PSIP1, TP53, IL2, FLT1, PDGFA, MDM2
28	Apoptotic Pathways in Synovial Fibroblasts36	8.9	NGFR, TP53, TGFB2, PSIP1, FLT1, EGFR
29	Nanog in Mammalian ESC Pluripotency36	8.8	NTRK1, PDGFA, ERBB2, APC, IL2, PDGFB
30	ILK Signaling36	8.7	TGFB2, EGFR, HIF1A, TIMP3, PSIP1, NTRK1
31	Mitochondrial Apoptosis36	8.7	NGFR, PDGFA, PDGFB, PDGFRA, EGF, EGFR
32	Cellular Apoptosis Pathway36	8.7	CDKN2A, FLT1, IL2, TP53, NTRK1, NGFR
33	PAK Pathway36	8.6	IL5, IL4, IL2, IL1B, IL1A, FLT1
34	Endothelin-1 Signaling Pathway36	8.6	IL10, EGFR, IL1B, PDGFRA, NTRK1, ERBB2
35	GSK3 Signaling36	8.6	EGF, PSIP1, FLT1, IL2, APC, TIMP3
36	Bladder cancer20	8.5	RB1, RASSF1, CDKN2A, CDK4, EGFR, EGF
37	Rho Family GTPases36	8.5	FLT1, IL4, CSF2, PSIP1, TGFB2, TIMP3
38	TGF-Beta Pathway36	8.4	TGFB2, IL10, IL1A, IL1B, IL2, IL5
39	MAPK Family Pathway36	8.3	PSIP1, TGFB2, EGFR, NGFR, EGF, PDGFB
40	Cytokine Network36	8.2	IFNG, IL10, IL5, IL1A, IL1B, IL2
41	Antioxidant Action of Vitamin-C36	8.1	PDGFA, CSF2, TGFB2, EGFR, EGF, PDGFB
42	Tec Kinases Signaling36	8.1	IL1B, EGFR, PDGFRA, PDGFB, IL1A, TGFB2
43	ERK Signaling36	8.0	PDGFA, PDGFB, PDGFRA, EGF, IL4, IL2
44	MAPK Signaling36	7.8	PDGFA, NGFR, NTRK1, TP53, ERBB2, IL2
45	Pathways in cancer20	7.5	BIRC5, CDKN2B, CDK4, MDM2, ERBB2, TP53
46	Pancreatic Adenocarcinoma36	7.5	PSIP1, MDM2, IL2, FLT1, CDK4, CDKN2A
47	Molecular Mechanisms of Cancer36	7.3	SOX9, SOX4, PSIP1, TGFB2, TIMP3, TSC2
48	p38 Signaling36	7.2	TGFB2, IL1B, IL5, ERBB2, TP53, NTRK1
49	JAK-STAT Pathway36	7.2	IL2, NGFR, NTRK1, ERBB2, PDGFA, IL4
50	Cytokine-cytokine receptor interaction20	7.0	IL1A, VEGFA, FLT1, IL10, IL2, IL4

Compounds related to ependymoma according to GeneDecks:

(show top 50)    (show all 354)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.4	IL1A, KRT18, TGFB2
2	vincristine32 34 9 9	13.4	NCAM1, MGMT, MAP2, TXN, CSF2
3	hematoxylin32	10.1	NCAM1, VIM, LGALS3, MUC1, S100B, CDKN2A
4	cyclic amp32 18	10.5	RB1, RARB, CDKN2A, CDK4, MMP14, IL1RAPL2
5	glucose32	9.4	BNIP3, LDHA, S100B, CDK4, MKI67, MGMT
6	dopamine32 9 18 9	12.3	NCAM1, RBP4, RARB, MTHFR, S100B, CDKN2A
7	o6-methylguanine32	9.0	BRCA2, RARB, RASSF1, CDKN2B, CDKN2A, MGMT
8	etoposide32 42 9 9	11.9	RB1, BIRC5, LGALS3, S100B, MGMT, MDM2
9	tgf beta132	8.9	CDKN2B, CDK4, MMP14, MKI67, FLT1, IL10
10	heparin32 9 18 9	11.8	NCAM1, NCL, VTN, VIM, SCG5, LGALS3
11	calcitriol32 42 9 18 9	12.8	RB1, RARB, PAX5, CDK4, MMP14, IL2
12	superoxide32 18	9.8	RB1, BIRC5, SCG5, LGALS3, CDK4, MMP14
13	forskolin32 42 9 9	11.7	VIM, RARB, MUC1, S100B, MMP14, IL1A
14	adenylate32	8.5	NCL, RBP4, VIM, RARB, S100B, IL1RAPL2
15	aspartate32	8.4	VTN, RBP4, VIM, S100B, CDKN2A, CA2
16	alanine32	8.4	NCAM1, VTN, RBP4, RASSF1, BIRC5, SCG5
17	azathioprine32 34 9 9	11.4	VIM, RARB, RASSF1, MTHFR, CDKN2B, CDKN2A
18	agar32	8.4	RB1, VIM, RARB, RASSF1, BIRC5, MUC1
19	atp32	8.3	NCAM1, NCL, VTN, RB1, BIRC5, SCG5
20	arginine32	8.3	NCL, VTN, RARB, SCG5, S100B, CDK4
21	wortmannin32 42	9.2	VTN, VIM, BIRC5, LGALS3, S100B, MMP14
22	n acetylcysteine32	8.1	BIRC5, CDKN2A, CDK4, ERBB2, TP53, TERT
23	matrigel32	8.1	NCAM1, VTN, RB1, VIM, BRCA2, VEGFA
24	glutamate32	8.1	NCAM1, VTN, VIM, SCG5, LGALS3, MTHFR
25	lipid32	8.1	NCAM1, NCL, VTN, RB1, RBP4, VIM
26	lactate32	8.0	NCAM1, VTN, RBP4, VIM, BNIP3, BIRC5
27	doxorubicin32 34 9 9	10.8	NCAM1, VIM, CDK4, MKI67, FLT1, MGMT
28	adriamycin32	7.7	RB1, VIM, BRCA2, BIRC5, MUC1, CDKN2A
29	oxygen32 18	8.6	RB1, RBP4, BIRC5, LGALS3, LDHA, CDKN2A
30	estrogen32	7.6	NCL, RBP4, BRCA2, BNIP3, RARB, RASSF1
31	sb 20358032 42	8.4	RB1, VIM, VEGFA, BNIP3, BIRC5, CDK4
32	resveratrol32 9 18 9	10.4	RB1, BRCA2, VEGFA, BIRC5, CDK4, MDM2
33	vitamin d32	7.2	VIM, RARB, PAX5, SCG5, LGALS3, MTHFR
34	glutamine32	7.2	NCAM1, VTN, VIM, BRCA2, SCG5, LGALS3
35	carboplatin32 34 9 9	10.1	RB1, VEGFA, MTHFR, CDK4, MGMT, IL1A
36	nitric oxide32 9 18 9	10.1	NCAM1, RB1, BNIP3, BIRC5, LGALS3, LDHA
37	herbimycin a32 42	7.9	VTN, CDK4, MMP14, IL1A, IL1B, IL2
38	gemcitabine32 34 9 9	9.8	VEGFA, BNIP3, BIRC5, MUC1, MTHFR, IL10
39	butyrate32	6.7	RB1, VIM, BIRC5, SCG5, LGALS3, MUC1
40	paclitaxel32 34 9 9	9.6	NCL, RB1, VIM, BRCA2, VEGFA, BNIP3
41	indomethacin32 9 9	8.5	VIM, BIRC5, IL1A, IL1B, IL1RAPL2, IL2
42	cisplatin32 34 9 9	8.5	VTN, RB1, BRCA2, VEGFA, RARB, RASSF1
43	5fluorouracil32	5.4	RB1, VEGFA, BNIP3, BIRC5, MUC1, MTHFR
44	paraffin32	5.2	NCAM1, RB1, VIM, BRCA2, VEGFA, BIRC5
45	retinoic acid32 42 18	6.8	NCAM1, NCL, VTN, RB1, RBP4, BRCA2
46	actinomycin d32	4.6	NCL, RB1, VIM, VEGFA, RARB, BIRC5
47	genistein32 9 18 9	7.4	RB1, VIM, BRCA2, VEGFA, RARB, BIRC5
48	dexamethasone32 42 34 9 9	6.9	NCAM1, VTN, RB1, RBP4, VIM, VEGFA
49	calcium32 9 18 9	INF	NCL, VTN, RB1, RBP4, BNIP3, BIRC5
50	cysteine32	INF	VTN, RBP4, RARB, SCG5, LGALS3, MUC1

Cellular components related to ependymoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	ruffle membrane	GO:032587	10.2	PLEK, APC, NF2, EZR, PDPN
2	intermediate filament	GO:005882	10.0	KRT18, KRT7, VIM, KRT20, GFAP, NES
3	platelet alpha granule lumen	GO:031093	9.2	PDGFA, VEGFA, PDGFB, EGF, TGFB2
4	protein complex	GO:043234	9.1	PTGS2, TSC1, SYP, SOX9, TP53, MDM2
5	nucleolus	GO:005730	8.0	MDM2, KRT7, NCL, SMARCB1, NF2, WT1
6	nucleoplasm	GO:005654	7.8	TPR, TERT, PPARG, SMARCB1, NOTCH1, NGFR
7	cytosol	GO:005829	6.5	PPARG, CTNNB1, PTEN, TXN, GLS, CA2
8	extracellular space	GO:005615	6.5	IL4, IL2, IL1A, IL10, FLT1, VEGFA
9	nucleus	GO:005634	6.0	EPB41, HIC1, HIF1A, TSC2, PSIP1, PRDX5
10	cytoplasm	GO:005737	INF	HIF1A, DAPK1, , PTGS2, PTEN, TERT
11	extracellular region	GO:005576	INF	IL1A, TGFB2, CSF2, ADCYAP1, GDNF, MUC1
12	extrinsic to membrane	GO:019898	INF	EPB41, EPB41L3, EZR, , NF2

Biological processes related to ependymoma according to GeneDecks:

(show top 50)    (show all 67)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of fibroblast proliferation	GO:048146	10.6	NGFR, CDK4, PDGFA, EGFR, PDGFB, PDGFRA
2	response to wounding	GO:009611	10.6	HOXB13, NGFR, PDGFA, PDGFB, GFAP, TGFB2
3	sympathetic nervous system development	GO:048485	10.4	NTRK1, NF1, SOX4, GDNF
4	negative regulation of epithelial cell proliferation	GO:050680	10.4	SOX9, TGFB2, PTEN, CDKN2B, RB1
5	positive regulation of DNA replication	GO:045740	10.4	PDGFB, EGFR, PDGFRA, CSF2, PDGFA
6	hair follicle development	GO:001942	10.4	APC, PDGFA, EGFR, SOX9, TGFB2
7	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.4	TGFB2, FLT1, PDGFA, PDGFB, PDGFRA, SOX9
8	activation of MAPKK activity	GO:000186	10.4	NTRK1
9	phosphatidylinositol-mediated signaling	GO:048015	10.2	MDM2, NTRK1, ERBB2, TSC2, PDGFRA, PTEN
10	kidney development	GO:001822	10.2	TGFB2, TSC1, CA2, WT1, TP73, APC
11	positive regulation of protein autophosphorylation	GO:031954	10.0	VEGFA, PDGFB, PDGFA, NGF
12	response to organic nitrogen	GO:010243	10.0	TGFB2, PTGS2, TP73, IL1B, IL1A
13	central nervous system development	GO:007417	10.0	PTEN, NGFR, IL1RAPL2, TIMP3, DCX, NES
14	wound healing	GO:042060	9.9	ERBB2, NF1, PDGFA, TGFB2, IL1A, PDGFRA
15	cellular response to organic substance	GO:071310	9.9	TIMP3, MAP2, IL1B, SYP
16	epidermal growth factor receptor signaling pathway	GO:007173	9.9	TSC2, EGFR, EGF, SHC3, PTEN, SOX9
17	transmembrane receptor protein tyrosine kinase signaling pathway	GO:007169	9.9	FLT1, NTRK1, NGF, SHC3, ADCYAP1, ERBB2
18	epithelial to mesenchymal transition	GO:001837	9.9	CTNNB1, NOTCH1, TGFB2, SOX9, HIF1A
19	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.8	NTRK1, PDGFB, PDGFA, PDGFRA, IL1B, IL1A
20	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061419	9.8	NOTCH1, HIF1A, VEGFA
21	positive regulation of cell migration	GO:030335	9.7	EGFR, FLT1, PDGFRA, VEGFA, MMP14, APC
22	response to estradiol stimulus	GO:032355	9.7	PDGFB, TGFB2, CTNNB1, ENO2, IL1B, BRCA2
23	response to gamma radiation	GO:010332	9.6	TP53, IL1B, MEN1, BRCA2, IL1A
24	heart development	GO:007507	9.6	RBP4, PDGFB, SOX4, TGFB2, TSC2, WT1
25	positive regulation of cell division	GO:051781	9.6	PDGFB, TGFB2, APC, PDGFA, MEN1, VEGFA
26	positive regulation vascular endothelial growth factor production	GO:010575	9.6	HIF1A, PTGS2, IL1B, IL1A
27	Ras protein signal transduction	GO:007265	9.5	RASSF1, RB1, TP53, CDKN2A, NTRK1, NGF
28	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	9.5	FLT1, HIF1A, IL1B, VTN, VEGFA
29	cell proliferation	GO:008283	9.4	TP53, TGFB2, EGFR, PDPN, PTEN, TXN
30	positive regulation of MAP kinase activity	GO:043406	9.3	PDGFA, VEGFA, EGF, ERBB2, FLT1, EGFR
31	platelet degranulation	GO:002576	9.2	VEGFA, PLEK, PDGFA, PDGFB, EGF, TGFB2
32	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.2	NGF, PPARG, PTEN, IL5, IL4, IL1B
33	anti-apoptosis	GO:006916	9.2	IL1A, GDNF, BNIP3, BIRC5, MUC1, IL10
34	inflammatory response	GO:006954	9.1	IL1A, PDPN, IL1B, NGF, TP73, IL5
35	response to hypoxia	GO:001666	9.1	VEGFA, FLT1, TGFB2, BNIP3, IL1A, IL1B
36	positive regulation of angiogenesis	GO:045766	9.1	IL1A, IL1B, NTRK1, FLT1, VEGFA, HIF1A
37	positive regulation of apoptotic process	GO:043065	9.0	SOX4, TP53, IL1B, MEN1, PTGS2, CTNNB1
38	cellular response to hypoxia	GO:071456	9.0	PTGS2, TP53, CA9, VEGFA, BNIP3, MDM2
39	angiogenesis	GO:001525	8.7	NCL, VEGFA, HOXB13, PTEN, PDGFA, EGF
40	cell cycle arrest	GO:007050	8.7	TP53, TP73, TSC1, TSC2, RB1, TGFB2
41	negative regulation of transcription, DNA-dependent	GO:045892	8.6	IL4, MEN1, SOX9, BIRC5, NOTCH1, RB1
42	negative regulation of apoptotic process	GO:043066	8.5	NES, KRT18, IL4, MDM2, APC, TP53
43	positive regulation of cell proliferation	GO:008284	8.4	MDM2, CSF2, SOX9, CDK4, PTEN, IL2
44	negative regulation of cell proliferation	GO:008285	8.0	NF2, CDKN2B, CDKN2A, MEN1, IL1A, IL1B
45	apoptotic process	GO:006915	8.0	PTEN, TP53, IFNG, DAPK1, VIM, CTNNB1
46	response to drug	GO:042493	7.8	ENO2, APC, IL4, CDK4, IL10, MGMT
47	positive regulation of transcription, DNA-dependent	GO:045893	6.9	IL10, NOTCH1, SOX4, HIF1A, EGF, WT1
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	6.0	PAX5, RARB, VEGFA, SOX4, RB1, CDKN2B
49	positive regulation of epithelial cell differentiation	GO:030858	INF	, SOX9, APC
50	virus-host interaction	GO:019048	INF	BNIP3, RB1, KRT18, TP53, , PDGFRA

Molecular functions related to ependymoma according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.9	FLT1, ERBB2, PDGFRA, EGFR, NTRK1
2	platelet-derived growth factor receptor binding	GO:005161	9.8	VEGFA, PDGFA, PDGFRA, PDGFB
3	identical protein binding	GO:042802	9.4	SYP, BNIP3, VIM, RASSF1, BIRC5, SCHIP1
4	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive	GO:001077	9.0	TP53, SOX4, SOX9, HIF1A, WT1
5	protein homodimerization activity	GO:042803	8.9	IDH1, ENO2, TERT, S100B, GDNF, TGFB2
6	protein kinase binding	GO:019901	8.8	CDKN2A, VIM, CDKN2B, APC, TP53, DCX
7	transcription regulatory region DNA binding	GO:044212	8.8	HIF1A, MEN1, TP53, TP73, CTNNB1, PPARG
8	enzyme binding	GO:019899	8.6	PPARG, NOTCH1, CTNNB1, PTGS2, PTEN, TP53
9	protein heterodimerization activity	GO:046982	8.3	VEGFA, TGFB2, HIF1A, EGFR, PDGFB, PDGFA
10	growth factor activity	GO:008083	7.7	TGFB2, CSF2, EGF, PDGFB, PDGFA, NGF
11	cytokine activity	GO:005125	7.5	IL1A, IL2, IL10, VEGFA, IL5, IFNG
12	protein binding	GO:005515	INF	IL1A, TPR, TERT, PTEN, , DAPK1