MCID: EPD015
MIFTS: 45

Epidemic Typhus

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Epidemic Typhus

MalaCards integrated aliases for Epidemic Typhus:

Name: Epidemic Typhus 12 49 55 3 14
Typhus 12 72 49 51 14 69
Endemic Flea-Borne Typhus 12 69
Brill-Zinsser Disease 49 69
Murine Typhus 12 49
Jail Fever 12 49
Epidemic Louse-Borne Typhus Fever Due to Rickettsia Prowazekii 12
Typhus Group Rickettsial Disease 69
Louse-Borne [epidemic] Typhus 12
Typhus, Epidemic Louse-Borne 69
Epidemic Louse-Borne Typhus 12
Typhus, Endemic Flea-Borne 41
Exanthematic Typhus Fever 12
Louse-Borne Rickettsiosis 12
Flea-Borne Rickettsiosis 12
Murine [endemic] Typhus 12
Typhus Exanthematique 12
Endemic Typhus Fever 12
Exanthematous Typhus 12
Louse-Borne Typhus 12
Epidemic Typhus 12
Flea-Borne Typhus 12
Classical Typhus 12
Sylvatic Typhus 12
European Typhus 12
Petechial Fever 12
Rat Flea Typhus 12
Relapsing Fever 69
Endemic Typhus 49
Hospital Fever 12
Mexican Typhus 12
Moscow Typhus 12
Urban Typhus 12
Famine Fever 12
Prison Fever 12
Typhus Fever 12
Shop Typhus 12
Flea Typhus 12
Ship Fever 12

Characteristics:

Orphanet epidemiological data:

55
epidemic typhus
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050480 DOID:11256
ICD9CM 34 080 081.0 081.9
Orphanet 55 ORPHA83314
MESH via Orphanet 42 D014438
UMLS via Orphanet 70 C0041473
ICD10 via Orphanet 33 A75.0

Summaries for Epidemic Typhus

CDC : 3 Typhus fevers are a group of diseases caused by bacteria that are spread to humans by fleas, lice, and chiggers. Typhus fevers include scrub typhus, murine typhus, and epidemic typhus. Chiggers spread scrub typhus, fleas spread murine typhus, and body lice spread epidemic typhus. The most common symptoms are fever, headaches, and sometimes rash.

MalaCards based summary : Epidemic Typhus, also known as typhus, is related to brill-zinsser disease and scrub typhus, and has symptoms including recurrent fevers An important gene associated with Epidemic Typhus is AFF2 (AF4/FMR2 Family Member 2), and among its related pathways/superpathways is Selenium Metabolism and Selenoproteins. The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include endothelial cells of the small venous, endothelial and testes.

Disease Ontology : 12 A primary bacterial infectious disease that refers to a group of diseases, located in endothelial cells of the small venous, arterial, and capillary vessels, has material basis in Rickettsia bacteria, which are transmitted_by lice, transmitted_by fleas, and transmitted_by mites.

Wikipedia : 72 Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus,... more...

Related Diseases for Epidemic Typhus

Diseases related to Epidemic Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 brill-zinsser disease 32.9 AFF2 CD40LG
2 scrub typhus 32.0 CD40LG GPT TCN2
3 spotted fever 30.2 AFF2 CCL5
4 rocky mountain spotted fever 30.2 AFF2 CD40LG MRRF
5 relapsing epidemic typhus 12.2
6 endemic typhus 11.6
7 pediculus humanus corporis infestation 11.1
8 flinders island spotted fever 10.4 AFF2 CD40LG
9 ornithosis 10.4 AFF2 CD40LG
10 fasciolopsiasis 10.4 CD40LG TCN2
11 japanese spotted fever 10.4 AFF2 CD40LG
12 toxocariasis 10.4 CD40LG TCN2
13 hepatitis d 10.2 CD40LG GPT
14 hemorrhagic fever 10.2 CD40LG GPT
15 vitamin b12 deficiency 10.2 GPT TCN2
16 hepatitis e 10.2 CD40LG GPT
17 african tick-bite fever 10.2 CCL5 CD40LG
18 inclusion conjunctivitis 10.1 CCL5 CD40LG
19 chikungunya 10.1 CCL5 CD40LG
20 parasitic protozoa infectious disease 10.1 CD40LG TCN2
21 trench fever 10.1
22 meningoencephalitis 10.1 CCL5 CD40LG
23 dengue disease 10.0 CCL5 CD40LG
24 idiopathic neutropenia 10.0 CCL5 CD40LG
25 severe acute respiratory syndrome 10.0 CCL5 CD40LG
26 human immunodeficiency virus infectious disease 10.0 CCL5 CD40LG
27 norwegian scabies 10.0 CD40LG NKX2-1
28 relapsing fever 9.9
29 ring chromosome y syndrome 9.9
30 temporal arteritis 9.9 CCL5 CD40LG
31 salmonellosis 9.8
32 pasteurellosis 9.8
33 pneumonia 9.8
34 viral infectious disease 9.8 CCL5 CD40LG GPT
35 blood group, i system 9.8
36 bacteremia 2 9.8
37 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
38 q fever 9.8
39 dysentery 9.8
40 louse-borne relapsing fever 9.8
41 parasitic ectoparasitic infectious disease 9.8
42 meningitis 9.8
43 encephalitis 9.8
44 transmitted_by 9.8
45 rabies 9.7 CCL5 CD40LG

Graphical network of the top 20 diseases related to Epidemic Typhus:



Diseases related to Epidemic Typhus

Symptoms & Phenotypes for Epidemic Typhus

UMLS symptoms related to Epidemic Typhus:


recurrent fevers

Drugs & Therapeutics for Epidemic Typhus

Drugs for Epidemic Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
3 Anti-Bacterial Agents Phase 4,Phase 3
4 Antibiotics, Antitubercular Phase 4
5 Anti-Infective Agents Phase 4,Phase 3
6 Antimalarials Phase 4,Phase 3
7 Antiparasitic Agents Phase 4,Phase 3
8 Antiprotozoal Agents Phase 4,Phase 3
9 Antitubercular Agents Phase 4
10
Telithromycin Approved Phase 3 191114-48-4 0 5462516
11
Rifampin Approved 13292-46-1 5381226 5458213
12
Ethanol Approved 64-17-5 702
13 Cytochrome P-450 CYP3A Inducers
14 Nucleic Acid Synthesis Inhibitors
15 Antibodies
16 Immunoglobulin A
17 Immunoglobulin M
18 Immunoglobulins
19 Vaccines

Interventional clinical trials:

(show all 11)

# Name Status NCT ID Phase Drugs
1 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Controlled Trial: 5-Day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00568711 doxycycline;rifampin
4 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
5 Scrub Typhus RDT Study Recruiting NCT03269266
6 Scrub Typhus Infection Induced Cardiovascular Disease Recruiting NCT03274869
7 Scrub Typhus Pediatric Immunology Study Recruiting NCT02398162
8 Causes of Fever in Bangladeshi Patients Recruiting NCT02339259
9 Lyme Test Indication Combinations (LyTIC) Study Recruiting NCT03201042
10 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Not yet recruiting NCT02876367
11 Eschar Investigations in Scrub Typhus Not yet recruiting NCT02915861

Search NIH Clinical Center for Epidemic Typhus

Cochrane evidence based reviews: typhus, endemic flea-borne

Genetic Tests for Epidemic Typhus

Anatomical Context for Epidemic Typhus

The Foundational Model of Anatomy Ontology organs/tissues related to Epidemic Typhus:

18
Endothelial Cells Of The Small Venous

MalaCards organs/tissues related to Epidemic Typhus:

38
Endothelial, Testes, Bone

Publications for Epidemic Typhus

Articles related to Epidemic Typhus:

(show top 50) (show all 109)
# Title Authors Year
1
The epidemic typhus and trench fever are risk for public health due to increased migration in southeast of Turkey. ( 29126839 )
2018
2
Rickettsia Prowazekii (Epidemic Typhus) ( 28846313 )
2017
3
The History of Epidemic Typhus. ( 27726780 )
2016
4
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012. ( 27352876 )
2016
5
An Overview of Epidemic Typhus in the World and Iran during the 19th and 20th Centuries. ( 27743443 )
2016
6
Drought and epidemic typhus, central Mexico, 1655-1918. ( 24564928 )
2014
7
Genome Sequencing of Four Strains of Rickettsia prowazekii, the Causative Agent of Epidemic Typhus, Including One Flying Squirrel Isolate. ( 23814035 )
2013
8
Environmental risk factors for epidemic typhus in the United States: wintertime is typhus time. ( 22533108 )
2012
9
Brill-Zinsser disease in a patient following infection with sylvatic epidemic typhus associated with flying squirrels. ( 20687836 )
2010
10
Cluster of sylvatic epidemic typhus cases associated with flying squirrels, 2004-2006. ( 19624912 )
2009
11
Epidemic typhus. ( 18582834 )
2008
12
A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus. ( 17537665 )
2007
13
Autochthonous epidemic typhus associated with Bartonella quintana bacteremia in a homeless person. ( 15891141 )
2005
14
Multispacer typing of Rickettsia prowazekii enabling epidemiological studies of epidemic typhus. ( 16145131 )
2005
15
The history of epidemic typhus. ( 15081509 )
2004
16
Reemerging threat of epidemic typhus in Algeria. ( 15297561 )
2004
17
Epidemic typhus meningitis in the southwestern United States. ( 11247722 )
2001
18
Serological differentiation of murine typhus and epidemic typhus using cross-adsorption and Western blotting. ( 10882661 )
2000
19
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. ( 10476755 )
1999
20
Epidemic typhus imported from Algeria. ( 10511530 )
1999
21
Outbreak of epidemic typhus associated with trench fever in Burundi. ( 9717922 )
1998
22
Imported epidemic typhus. ( 9853468 )
1998
23
Outbreak of epidemic typhus in Russia. ( 9798622 )
1998
24
Epidemic typhus in a prison in Burundi. ( 9196749 )
1997
25
Jail fever (epidemic typhus) outbreak in Burundi. ( 9284381 )
1997
26
How Charles Nicolle of the Pasteur Institute discovered that epidemic typhus is transmitted by lice: reminiscences from my years at the Pasteur Institute in Paris. ( 8855211 )
1996
27
Epidemic typhus risk in Rwandan refugee camps. ( 7947074 )
1994
28
Epidemic typhus fever and hearing loss: a histological study (Hallpike collection of temporal bone sections). ( 8320509 )
1993
29
A clinico-epidemiological study of epidemic typhus in Africa. ( 1600020 )
1992
30
Cardiovascular and pulmonary complications of epidemic typhus. ( 2763350 )
1989
31
Decreased oxygen utilization in epidemic typhus infection: case report with sequential hemodynamic studies. ( 3177416 )
1988
32
Flying squirrels and their ectoparasites: disseminators of epidemic typhus. ( 15462918 )
1987
33
Rickettsial vaccines with emphasis on epidemic typhus. Initial report of an old vaccine trial. ( 3095934 )
1986
34
Flying squirrel-associated Rickettsia prowazekii (epidemic typhus rickettsiae) characterized by a specific DNA fragment produced by restriction endonuclease digestion. ( 3009528 )
1986
35
Epidemic typhus acquired in Wisconsin. ( 3976245 )
1985
36
Epidemic typhus--Georgia. ( 6436662 )
1984
37
Detection and characterization of mouse monoclonal antibodies to epidemic typhus rickettsiae. ( 6415092 )
1983
38
Murine and epidemic typhus rickettsiae: how close is their relationship? ( 6817526 )
1982
39
Epidemic typhus associated with flying squirrels--United States. ( 6817059 )
1982
40
Suspected Rocky Mountain spotted fever in the winter--epidemic typhus? ( 7312012 )
1981
41
Epidemic typhus (Rickettsia prowazekii) in Massachusetts: evidence of infection. ( 6783902 )
1981
42
Epidemic typhus in the United States associated with flying squirrels. ( 6785459 )
1981
43
Indigenous acquisition of epidemic typhus in the eastern United States. ( 6781073 )
1981
44
Epidemic typhus infection in cynomolgus monkeys (Macaca fascicularis). ( 7439974 )
1980
45
Epizootiology of epidemic typhus (Rickettsia prowazekii) in flying squirrels. ( 646026 )
1978
46
Prescription and devotion: the Reverend Doctor Donne and the learned Doctor Mayerne--two seventeenth-century records of epidemic typhus fever. ( 362088 )
1978
47
Serologic diagnosis of epidemic typhus fever. ( 403761 )
1977
48
John Donne's Devotions: an early record of epidemic typhus. ( 791999 )
1976
49
A reference, inactivated, epidemic typhus vaccine: clinical trials in man. ( 820697 )
1976
50
Epidemic typhus rickettsiae isolated from flying squirrels. ( 806809 )
1975

Variations for Epidemic Typhus

Expression for Epidemic Typhus

Search GEO for disease gene expression data for Epidemic Typhus.

Pathways for Epidemic Typhus

Pathways related to Epidemic Typhus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.29 SARS SARS2

GO Terms for Epidemic Typhus

Biological processes related to Epidemic Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.43 AFF2 NKX2-1 POU3F3
2 tRNA aminoacylation for protein translation GO:0006418 9.32 SARS SARS2
3 leukocyte cell-cell adhesion GO:0007159 9.16 CCL5 CD40LG
4 selenocysteinyl-tRNA(Sec) biosynthetic process GO:0097056 8.96 SARS SARS2
5 seryl-tRNA aminoacylation GO:0006434 8.62 SARS SARS2

Molecular functions related to Epidemic Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aminoacyl-tRNA ligase activity GO:0004812 8.96 SARS SARS2
2 serine-tRNA ligase activity GO:0004828 8.62 SARS SARS2

Sources for Epidemic Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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