MCID: EPD015
MIFTS: 43

Epidemic Typhus malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Epidemic Typhus

Aliases & Descriptions for Epidemic Typhus:

Name: Epidemic Typhus 12 50 56 3 14
Typhus 12 50 52 14 69
Endemic Flea-Borne Typhus 12 69
Brill-Zinsser Disease 50 69
Murine Typhus 12 50
Jail Fever 12 50
Epidemic Louse-Borne Typhus Fever Due to Rickettsia Prowazekii 12
Typhus Group Rickettsial Disease 69
Louse-Borne [epidemic] Typhus 12
Typhus, Epidemic Louse-Borne 69
Epidemic Louse-Borne Typhus 12
Typhus, Endemic Flea-Borne 42
Exanthematic Typhus Fever 12
Louse-Borne Rickettsiosis 12
Flea-Borne Rickettsiosis 12
Murine [endemic] Typhus 12
Typhus Exanthematique 12
Endemic Typhus Fever 12
Exanthematous Typhus 12
Louse-Borne Typhus 12
Epidemic Typhus 12
Flea-Borne Typhus 12
Classical Typhus 12
Sylvatic Typhus 12
European Typhus 12
Petechial Fever 12
Rat Flea Typhus 12
Relapsing Fever 69
Endemic Typhus 50
Hospital Fever 12
Mexican Typhus 12
Moscow Typhus 12
Urban Typhus 12
Famine Fever 12
Prison Fever 12
Typhus Fever 12
Shop Typhus 12
Flea Typhus 12
Ship Fever 12

Characteristics:

Orphanet epidemiological data:

56
epidemic typhus
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050480 DOID:11256
ICD9CM 35 080 081.0 081.9
Orphanet 56 ORPHA83314
MESH via Orphanet 43 D014438
UMLS via Orphanet 70 C0041473
ICD10 via Orphanet 34 A75.0

Summaries for Epidemic Typhus

Disease Ontology : 12 A typhus that has material basis in Rickettsia prowazekii, which is transmitted_by human body louse (Pediculus humanus corporis). The infection has symptom high fever, has symptom cough, has symptom rash, has symptom severe muscle pain, has symptom chills, has symptom falling blood pressure, has symptom stupor, has symptom sensitivity to light, and has symptom delirium.

MalaCards based summary : Epidemic Typhus, also known as typhus, is related to rocky mountain spotted fever and endemic typhus, and has symptoms including high fever, cough and rash. An important gene associated with Epidemic Typhus is AFF2 (AF4/FMR2 Family Member 2), and among its related pathways/superpathways is Selenium Metabolism and Selenoproteins. The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include bone.

Wikipedia : 71 Epidemic typhus is a form of typhus so named because the disease often causes epidemics following wars... more...

Related Diseases for Epidemic Typhus

Diseases related to Epidemic Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
id Related Disease Score Top Affiliating Genes
1 rocky mountain spotted fever 30.1 AFF2 CD40LG
2 endemic typhus 12.5
3 relapsing epidemic typhus 12.0
4 scrub typhus 11.4
5 brill-zinsser disease 11.4
6 pediculus humanus corporis infestation 11.0
7 rabies 10.3 AFF2 CD40LG
8 hemorrhagic fever with renal syndrome 10.3 AFF2 CD40LG
9 dermatophytosis 10.2 CD40LG TCN2
10 oropharyngeal anthrax 10.2 AFF2 CD40LG
11 central gyrate choroidal dystrophy 10.2 CD40LG TCN2
12 pestis minor 10.1 AFF2 CD40LG MRRF
13 maxillary sinusitis 10.1 CD40LG GPT
14 congenital intrinsic factor deficiency 10.1 GPT TCN2
15 hereditary alpha tryptasemia syndrome 10.1 CD40LG GPT
16 benign deep fibrous histiocytoma 10.0 CD40LG GPT
17 israeli tick typhus 10.0 CCL5 CD40LG
18 megaloblastic anemia 10.0 CD40LG GPT TCN2
19 chronic subinvolution of uterus 10.0 CCL5 CD40LG
20 mineral metabolism disease 10.0 CCL5 CD40LG
21 early yaws 9.9 CCL5 CD40LG
22 dentinogenesis imperfecta 9.9 CCL5 CD40LG
23 hyperimmunoglobulin syndrome 9.9 CCL5 CD40LG
24 trench fever 9.9
25 spotted fever 9.9
26 immunoglobulin g deficiency 9.9 CCL5 CD40LG
27 relapsing fever 9.8
28 stiff-person syndrome 9.8 CCL5 CD40LG
29 exophthalmos 9.8 CCL5 CD40LG GPT
30 pneumonia 9.7
31 salmonellosis 9.7
32 pasteurellosis 9.7
33 louse-borne relapsing fever 9.7
34 bacteremia 9.7
35 meningitis 9.7
36 encephalitis 9.7
37 transmitted_by 9.7
38 q fever 9.7
39 dysentery 9.7
40 pancytopenia 9.4
41 sennetsu fever 8.6 AFF2 ARRB2 CCL5 CD40LG GPT MRRF

Graphical network of the top 20 diseases related to Epidemic Typhus:



Diseases related to Epidemic Typhus

Symptoms & Phenotypes for Epidemic Typhus

Symptoms:

12
  • high fever
  • cough
  • rash
  • severe muscle pain
  • chills
  • falling blood pressure
  • stupor
  • sensitivity to light
  • delirium

UMLS symptoms related to Epidemic Typhus:


recurrent fevers

Drugs & Therapeutics for Epidemic Typhus

Drugs for Epidemic Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
3 Anti-Bacterial Agents Phase 4,Phase 3
4 Antibiotics, Antitubercular Phase 4
5 Anti-Infective Agents Phase 4,Phase 3
6 Antimalarials Phase 4,Phase 3
7 Antiparasitic Agents Phase 4,Phase 3
8 Antiprotozoal Agents Phase 4,Phase 3
9 Antitubercular Agents Phase 4
10
Telithromycin Approved Phase 3 191114-48-4 5462516
11
Rifampin Approved 13292-46-1 5458213 5381226
12 Cytochrome P-450 CYP3A Inducers
13 Nucleic Acid Synthesis Inhibitors
14 Vaccines

Interventional clinical trials:


id Name Status NCT ID Phase
1 Scrub Typhus Antibiotic Resistance Trial Not yet recruiting NCT03083197 Phase 4
2 Controlled Trial: 5-Day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00351182 Phase 3
3 Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00568711
4 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
5 Scrub Typhus Pediatric Immunology Study Recruiting NCT02398162
6 Causes of Fever in Bangladeshi Patients Recruiting NCT02339259
7 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Not yet recruiting NCT02876367
8 Eschar Investigations in Scrub Typhus Not yet recruiting NCT02915861

Search NIH Clinical Center for Epidemic Typhus

Cochrane evidence based reviews: typhus, endemic flea-borne

Genetic Tests for Epidemic Typhus

Anatomical Context for Epidemic Typhus

MalaCards organs/tissues related to Epidemic Typhus:

39
Bone

Publications for Epidemic Typhus

Articles related to Epidemic Typhus:

(show top 50) (show all 107)
id Title Authors Year
1
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012. ( 27352876 )
2016
2
An Overview of Epidemic Typhus in the World and Iran during the 19th and 20th Centuries. ( 27743443 )
2016
3
The History of Epidemic Typhus. ( 27726780 )
2016
4
Drought and epidemic typhus, central Mexico, 1655-1918. ( 24564928 )
2014
5
Genome Sequencing of Four Strains of Rickettsia prowazekii, the Causative Agent of Epidemic Typhus, Including One Flying Squirrel Isolate. ( 23814035 )
2013
6
Environmental risk factors for epidemic typhus in the United States: wintertime is typhus time. ( 22533108 )
2012
7
Brill-Zinsser disease in a patient following infection with sylvatic epidemic typhus associated with flying squirrels. ( 20687836 )
2010
8
Cluster of sylvatic epidemic typhus cases associated with flying squirrels, 2004-2006. ( 19624912 )
2009
9
Epidemic typhus. ( 18582834 )
2008
10
A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus. ( 17537665 )
2007
11
Multispacer typing of Rickettsia prowazekii enabling epidemiological studies of epidemic typhus. ( 16145131 )
2005
12
Autochthonous epidemic typhus associated with Bartonella quintana bacteremia in a homeless person. ( 15891141 )
2005
13
The history of epidemic typhus. ( 15081509 )
2004
14
Reemerging threat of epidemic typhus in Algeria. ( 15297561 )
2004
15
Epidemic typhus meningitis in the southwestern United States. ( 11247722 )
2001
16
Serological differentiation of murine typhus and epidemic typhus using cross-adsorption and Western blotting. ( 10882661 )
2000
17
Epidemic typhus imported from Algeria. ( 10511530 )
1999
18
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. ( 10476755 )
1999
19
Outbreak of epidemic typhus associated with trench fever in Burundi. ( 9717922 )
1998
20
Outbreak of epidemic typhus in Russia. ( 9798622 )
1998
21
Imported epidemic typhus. ( 9853468 )
1998
22
Epidemic typhus in a prison in Burundi. ( 9196749 )
1997
23
Jail fever (epidemic typhus) outbreak in Burundi. ( 9284381 )
1997
24
How Charles Nicolle of the Pasteur Institute discovered that epidemic typhus is transmitted by lice: reminiscences from my years at the Pasteur Institute in Paris. ( 8855211 )
1996
25
Epidemic typhus risk in Rwandan refugee camps. ( 7947074 )
1994
26
Epidemic typhus fever and hearing loss: a histological study (Hallpike collection of temporal bone sections). ( 8320509 )
1993
27
A clinico-epidemiological study of epidemic typhus in Africa. ( 1600020 )
1992
28
Cardiovascular and pulmonary complications of epidemic typhus. ( 2763350 )
1989
29
Decreased oxygen utilization in epidemic typhus infection: case report with sequential hemodynamic studies. ( 3177416 )
1988
30
Flying squirrels and their ectoparasites: disseminators of epidemic typhus. ( 15462918 )
1987
31
Rickettsial vaccines with emphasis on epidemic typhus. Initial report of an old vaccine trial. ( 3095934 )
1986
32
Flying squirrel-associated Rickettsia prowazekii (epidemic typhus rickettsiae) characterized by a specific DNA fragment produced by restriction endonuclease digestion. ( 3009528 )
1986
33
Epidemic typhus acquired in Wisconsin. ( 3976245 )
1985
34
Epidemic typhus--Georgia. ( 6436662 )
1984
35
Detection and characterization of mouse monoclonal antibodies to epidemic typhus rickettsiae. ( 6415092 )
1983
36
Epidemic typhus associated with flying squirrels--United States. ( 6817059 )
1982
37
Murine and epidemic typhus rickettsiae: how close is their relationship? ( 6817526 )
1982
38
Epidemic typhus in the United States associated with flying squirrels. ( 6785459 )
1981
39
Indigenous acquisition of epidemic typhus in the eastern United States. ( 6781073 )
1981
40
Epidemic typhus (Rickettsia prowazekii) in Massachusetts: evidence of infection. ( 6783902 )
1981
41
Suspected Rocky Mountain spotted fever in the winter--epidemic typhus? ( 7312012 )
1981
42
Epidemic typhus infection in cynomolgus monkeys (Macaca fascicularis). ( 7439974 )
1980
43
Prescription and devotion: the Reverend Doctor Donne and the learned Doctor Mayerne--two seventeenth-century records of epidemic typhus fever. ( 362088 )
1978
44
Epizootiology of epidemic typhus (Rickettsia prowazekii) in flying squirrels. ( 646026 )
1978
45
Serologic diagnosis of epidemic typhus fever. ( 403761 )
1977
46
John Donne's Devotions: an early record of epidemic typhus. ( 791999 )
1976
47
A reference, inactivated, epidemic typhus vaccine: clinical trials in man. ( 820697 )
1976
48
Epidemic typhus rickettsiae isolated from flying squirrels. ( 806809 )
1975
49
Single-dose doxycycline treatment of louse-borne relapsing fever and epidemic typhus. ( 4143011 )
1974
50
Single-dose treatment of epidemic typhus with doxycyline. ( 4580526 )
1973

Variations for Epidemic Typhus

Expression for Epidemic Typhus

Search GEO for disease gene expression data for Epidemic Typhus.

Pathways for Epidemic Typhus

Pathways related to Epidemic Typhus according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.29 SARS SARS2

GO Terms for Epidemic Typhus

Biological processes related to Epidemic Typhus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 translation GO:0006412 9.58 MRRF SARS SARS2
2 brain development GO:0007420 9.5 AFF2 ARRB2 POU3F3
3 positive regulation of T cell proliferation GO:0042102 9.43 CCL5 CD40LG
4 tRNA aminoacylation for protein translation GO:0006418 9.37 SARS SARS2
5 leukocyte cell-cell adhesion GO:0007159 9.26 CCL5 CD40LG
6 positive regulation of calcium ion transport GO:0051928 9.16 ARRB2 CCL5
7 selenocysteinyl-tRNA(Sec) biosynthetic process GO:0097056 8.96 SARS SARS2
8 seryl-tRNA aminoacylation GO:0006434 8.62 SARS SARS2

Molecular functions related to Epidemic Typhus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 aminoacyl-tRNA ligase activity GO:0004812 8.96 SARS SARS2
2 serine-tRNA ligase activity GO:0004828 8.62 SARS SARS2

Sources for Epidemic Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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