Epididymitis malady

Wikipedia: Epididymitis (⁴⁴ more...

MalaCards: Epididymitis is related to cystadenoma and azoospermia. An important gene associated with Epididymitis is EDDM3B (epididymal protein 3B), and among its related pathways are Leukocyte transendothelial migration and Tight junction. The drugs ofloxacin and ceftriaxone sodium and the compounds percoll and glucose have been mentioned in the context of this disorder. Affiliated tissues include thyroid, prostate and testis, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

epididymitis 8 43

Diseases related to epididymitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 346)

id	Related Disease	Score	Top Affiliating Genes
1	cystadenoma	27.2	VHL, CLDN4, CLU, CLDN3, FSHR, AR
2	azoospermia	27.2	CGB5, CFTR, FSHR, AR, ESR1, ESR2
3	spermatocele	26.9	IL6, IL8, TNF
4	retinol binding protein	26.8	RBP4, CKM, HSP90B1, ESR1, TNF, PTGDS
5	male infertility	26.7	CFTR, FSHR, AR, CAT, ESR2, TXN
6	infertility	24.2	SERPINA5, SERPINA1, SERPING1, CLU, CKM, CGB5
7	prostate carcinoma	22.4	LPL, VDR, CLU, CEACAM1, FSHR, CDC25C
8	thyroiditis	19.9	RBP4, SERPINA1, VHL, LPL, VDR, CLDN4
9	prostatitis	19.4	BTRC, RBP4, SEMG2, SERPINA5, SERPINA1, VHL
10	adenocarcinoma	17.7	BTRC, RBP4, SERPINA1, VHL, LPL, VDR
11	carcinoma	17.5	ZNF77, PCTP, BTRC, RBP4, SEMG2, SERPINA5
12	renal tubular acidosis	13.9	CLCN5, ATP6V1B2, ATP6V0A1, CA2, TCIRG1, SLC9A3
13	osteopetrosis	13.6	CLCN3, CLCN4, CKB, ATP6V1B2, ATP6V0A1, CA2
14	transthyretin amyloidosis	13.5	RBP4, CLU, TTR
15	y chromosome infertility	13.4	CGB5, CFTR, FSHR, AR, ACR
16	cerebral hemorrhage	13.4	IL6, CTSD, SOD1, CST11, CST2, CST8
17	prostate cancer	13.4	AR, GSTP1, KLK3, ACPP
18	breast cyst	13.3	CGB5, CYP19A1, CTSD, KLK3
19	prostate disease	13.2	AR, CYP19A1, KLK3, ACPP
20	complete androgen insensitivity syndrome	13.2	AR, CYP19A1, NR1H2
21	hyperinsulinism	13.1	RBP4, LPL, KCNJ11, GLUD1, NR1H2, G6PC
22	li-fraumeni syndrome	13.1	ESR1, ESR2, SULT1E1, CYP19A1, CTSD
23	gender identity disorder	13.0	AR, ESR1, ESR2, CYP19A1
24	duchenne muscular dystrophy	13.0	CKB, CKM, P2RX4, AZU1, AR, HLA-B
25	perinatal necrotizing enterocolitis	13.0	CLDN3, IL6, TNF, LTF
26	fragile x-associated primary ovarian insufficiency	13.0	CGB5, FSHR, ESR1, ESR2, CYP19A1
27	endocarditis	13.0	SERPINA1, CKB, AQP9, ANXA5, GNB2L1, CAT
28	alcoholic pancreatitis	13.0	LPL, CFTR, GSTP1, CAT, LTF
29	lactic acidosis	13.0	CFTR, ATP5E, CAT, TNF, DLAT, G6PC
30	osteoporosis, postmenopausal	12.9	VDR, ESR1, ESR2, CYP19A1, CYP27B1
31	glycogen storage disease type ia	12.9	LPL, IL8, CAT, G6PC, SOD1
32	urinary bladder cancer	12.9	ZNF77, CLU, CEACAM1, GSTP1, CTSD, KLK3
33	rosacea	12.9	VDR, GSTP1, IL8, CAMP, SOD1
34	hereditary pancreatitis	12.9	SERPINA1, LPL, CLU, CFTR, CA2, LTF
35	urolithiasis	12.9	VDR, CKB, CKM, AR, IL6, CA2
36	clear cell adenocarcinoma	12.9	ESR1, ESR2, KLK3, ACPP, HIF1A, SLC22A16
37	autoimmune pancreatitis	12.8	CFTR, CA2, HLA-B, TNF, LTF
38	fabry disease	12.8	VDR, ATP6V0A1, FUCA1, IL6, M6PR, TNF
39	mayer-rokitansky-kuster-hauser syndrome	12.8	SERPINA1, VHL, LPL, VDR, CLCN5, CFTR
40	retinal disease	12.8	RBP4, VHL, LPL, CA2, NR1H2, LTF
41	prostatic hypertrophy	12.8	AR, GSTP1, ESR1, CYP19A1, KLK3, ACPP
42	male breast cancer	12.7	AR, ESR1, ESR2, CYP19A1, CTSD, KLK3
43	pancreatic ductal carcinoma	12.7	CLDN4, CLDN7, AR, GSTP1, ESR1, ESR2
44	aseptic meningitis	12.7	FLNA, IL8, CAT, TNF, SOD1
45	giant cell tumor	12.7	CLDN7, CLU, CKB, CEBPB, ANXA5, CA2
46	biliary tract cancer	12.7	SERPINA1, CLDN2, CLDN4, CLDN10, IL6, IL8
47	insulinoma	12.7	SERPINA1, KCNJ11, CGB5, FURIN, CAT, GLUD1
48	glycogen storage disease	12.7	RBP4, LPL, CKM, IL8, CAT, G6PC
49	cholecystitis	12.7	CLDN2, CLDN1, IL6, CAT, TNF, SOD1
50	ovarian cyst	12.7	CGB5, GSTP1, ESR1, ESR2, CYP19A1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 ceftriaxone, ceftriaxone sodium, ofloxacin

MalaCards organs/tissues related to epididymitis:

²²

MGI Mouse Phenotypes related to epididymitis:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.8	MFGE8, BTRC, VHL, CLDN7, FLNA, AQP9
2	endocrine/exocrine gland phenotype	MP:0005379	9.5	NTN1, PPP1CC, CRISP1, TCIRG1, SLC9A3, ZPBP
3	integument phenotype	MP:0010771	9.2	NTN1, NOTCH1, ACPP, OXT, POU5F1, SPAG9
4	renal/urinary system phenotype	MP:0005367	8.5	CUX1, NOTCH1, COL18A1, G6PC, HIF1A, OXT
5	liver/biliary system phenotype	MP:0005370	8.2	HIF1A, NR1H2, CYP19A1, PRKAG1, PRKAB1, SOD1
6	reproductive system phenotype	MP:0005389	8.0	ODF2, RSPH1, CRISP3, CRISP1, NR1H2, PPP1CC
7	skeleton phenotype	MP:0005390	8.0	ESR2, ESR1, IL6, AR, CEBPB, CLCN5
8	immune system phenotype	MP:0005387	8.0	ROCK1, P2RX2, CLU, CLCN3, VDR, BTRC
9	digestive/alimentary phenotype	MP:0005381	7.5	TNF, OFD1, ODF2, CTSD, ESR2, ESR1
10	tumorigenesis	MP:0002006	7.3	HIF1A, GSTP1, TNF, BTRC, VHL, PTGDS
11	growth/size phenotype	MP:0005378	7.2	PDIA3, ABCC9, LPL, ACE, RSPH1, G6PC
12	muscle phenotype	MP:0005369	6.6	CLU, NOTCH1, NR1H2, CYP19A1, TNF, ABCC9
13	cardiovascular system phenotype	MP:0005385	6.3	HIF1A, ESR2, TNF, CYP19A1, NR1H2, ROCK1
14	cellular phenotype	MP:0005384	5.9	HSP90B1, NTN1, CTSD, SPINK2, CUX1, ODF2
15	mortality/aging	MP:0010768	5.6	P2RX3, CTSD, NTN1, NR1H2, NOTCH1, PFN1
16	homeostasis/metabolism phenotype	MP:0005376	5.4	CLCN5, CLDN1, KCNJ11, CKM, P2RX2, CLU

Articles related to epididymitis:

(show top 50)    (show all 126)

id	Title	Authors	Year	Affiliating Genes
1	Alterations in the human blood-epididymis barrier in obstructive azoospermia and the development of novel epididymal cell lines from infertile men. (20505168)	Dube E.... Cyr D.G.	2010	EPPIN
2	Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa. (20400973)	Kameshwari D.B.... Shivaji S.	2010	HSP90B1, DLAT, PDIA3
3	Organic cation/carnitine transporter, OCTN2, transcri ptional activity is regulated by osmotic stress in epididymal cells. (19899138)	Cotton L.M.... Hinton B.T.	2010	SLC22A5
4	Testicular steroid hormone secretion in the boar and expression of testicular and epididymal steroid sulphatase and estrogen sulphot ransferase activity. (19795339)	Hoffmann B.... Goericke-Pesch S.	2010	SULT1E1
5	Assessing the role of claudins in maintaining the int egrity of epididymal tight junctions using novel human epididymal cell lines. (20164436)	DubAc E.... Cyr D.G.	2010	CLDN1, CLDN4, CLDN7
6	AMP-activated protein kinase inhibits alkaline pH- an d PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. (19211918)	Hallows K.R.... Pastor-Soler N.M.	2009	PRKAB1, PRKAA1, PRKAG1
7	Recombinant expression and affinity purification of a novel epididymal human sperm-binding protein, BSPH1. (19091820)	Lefebvre J.... Manjunath P.	2009	PCTP, BSPH1
8	Testicular and epididymal dual origin of hCAP-18/SOB3, a human sperm protein. (18258235)	Doussau M.... Finaz C.	2008	CAMP
9	KATP channel subunits are expressed in the epididymal epithelium in several mammalian species. (18434629)	Lybaert P.... Lebrun P.	2008	KCNJ11, ABCC9, AQP9
10	Vitamin D3 and androgen receptors in testis and epididymal region of roosters (Gallus domesticus) as affected by epididymal lithiasis. (18164879)	Oliveira A.G.... Oliveira C.A.	2008	VDR
11	Advances in the studies of epididymal protease inhibitor--Eppin (17345778)	Wang Z.J.... Zhang W.	2007	EPPIN
12	Rat epididymal epithelial cells and 17beta-estradiol synthesis under hCG stimulation in vitro. (17951176)	Awider-Al-Amawi M.... Wiszniewska B.	2007	CGB5
13	Epididymal P34H protein deficiency in men evaluated for infertility. (17434498)	Moskovtsev S.I.... Mullen J.B.	2007	DCXR
14	Distribution of vitamin D3 receptor in the epididymal region of roosters (Gallus domesticus) is cell and segment specific. (17156784)	Dornas R.A.... Oliveira C.A.	2007	CYP27B1
15	Effect of egg yolk and seminal plasma heparin binding protein interaction on the freezability of buffalo cauda epididymal spermatozoa. (17156949)	Singh L.P.... Ansari M.R.	2007	AZU1
16	Proteins of the cauda epididymal fluid associated with fertility of mature dairy bulls. (16582409)	Moura A.A.... Killian G.J.	2006	PTGDS, FUCA2
17	Comparison between different markers for sperm qualit y in the cat: Diff-Quik as a simple optical technique to assess changes in the DNA of feline epididymal sperm. (16256187)	Mota P.C.... Ramalho-Santos J.	2006	ANXA5
18	Epididymal cystadenomas and epithelial tumourlets: ef fects of VHL deficiency on the human epididymis. (16841375)	GlAosker S.... Vortmeyer A.O.	2006	VHL
19	Advances in the study of epididymal protease inhibitor (16333968)	Guo X.Q.... Wang R.J.	2005	EPPIN
20	A T3 allele in the CFTR gene exacerbates exon 9 skipping in vas deferens and epididymal cell lines and is associated with Congenital Bilateral Absence of Vas Deferens (CBAVD). (15580565)	Disset A.... Tuffery-Giraud S.	2005	CFTR
21	Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. (15367682)	Davies B.... Gottwald U.	2004	GPR64
22	Molecular evolution of epididymal lipocalin genes localized on mouse chromosome 2. (15363845)	Suzuki K.... Orgebin-Crist M.-C.	2004	LCN10, LCN12, LCN6
23	Cres2 and Cres3: new members of the cystatin-related epididymal spermatogenic subgroup of family 2 cystatins. (12586767)	Hsia N.... Cornwall G.A.	2003	CST2, CST8, CST9L
24	A putative 12-transmembrane domain cotransporter associated with apical membranes of the epididymal duct. (12826694)	Obermann H.... Kirchhoff C.	2003	SLC46A2
25	Comparison, characterization, and identification of p roteases and protease inhibitors in epididymal fluids of domestic mammals. Matr ix metalloproteinases are major fluid gelatinases. (11967181)	MActayer S.... Gatti J.L.	2002	ACR
26	Mannose-6-phosphate receptors as a molecular indicator of maturation of epididymal sperm. (11789684)	Belmonte S.A.... Sosa M.A.	2002	M6PR
27	Two-dimensional complementary deoxyribonucleic acid electrophoresis revealing up-regulated human epididymal protein-1 and down-regulated CL-100 in thyroid papillary carcinoma. (12399439)	Asakawa J.... Sugawara M.	2002	NPC2
28	Human epididymal proteins and sperm function during fertilization: un update. (11715855)	Lasserre A.... Vazquez-Levin M.H.	2001	EDDM3B, EDDM3A
29	Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg. (11566719)	Cohen D.J.... Cuasnicu P.S.	2001	CRISP1
30	Epididymal epithelium immortalized by simian virus 40 large T antigen: a model to study epididymal gene expression. (11574662)	Telgmann R.... Kirchhoff C.	2001	NPC2, WFDC2
31	Testase 1 (ADAM 24) a plasma membrane-anchored sperm protease implicated in sperm function during epididymal maturation or fertiliza tion. (11309208)	Zhu G.Z.... Primakoff P.	2001	ADAM1A
32	Identification of maturation-related wheat-germ lectin-binding proteins in the culture of human corpus epididymal epithelial cells. (10959503)	Sun G.H.... Chang S.Y.	2000	ADAM7
33	Stallion epididymal fluid proteome: qualitative and quantitative characterization; secretion and dynamic changes of major proteins. (10819784)	Fouchecourt S.... Dacheux J.L.	2000	PTGDS
34	Spatiotemporal patterns of expression of neurotrophins and neurotrophin receptors in mice suggest functional roles in testicular and epididymal morphogenesis. (10491653)	Russo M.A.... Siracusa G.	1999	CUX1
35	Glutathione-independent prostaglandin D2 synthase in ram and stallion epididymal fluids: origin and regulation. (10026099)	Fouchecourt S.... Dacheux J.L.	1999	PTGDS
36	Structure, alternative splicing and chromosomal localization of the cystatin-related epididymal spermatogenic gene. (10229662)	Cornwall G.A.... Sutton H.G.	1999	CST8
37	Cytoplasmic extrusion and the switch from creatine kinase B to M isoform are completed by the commencement of epididymal transport in human and stallion spermatozoa. (9537287)	Huszar G.... Johnson L.	1998	CKM, CKB
38	Localization of glucose-6-phosphatase activity and carbohydrates in boar caput epididymal principal cells. (9875161)	Geissbuhler D.M.... Stoffel M.H.	1998	G6PC
39	Function of human epididymal proteins in sperm maturation. (9739419)	Kirchhoff C.... Schroter S.	1998	GPX5, GPR64, CRISP1
40	Molecular characterization of epididymal proteins. (9685187)	Kirchhoff C.	1998	WFDC2, CRISP1, EDDM3B
41	Epididymal and sex accessory gland secretions in tran sfusion-dependent beta-thalassemic patients: evidence of an impaired prostatic function. (9228514)	Carpino A.... AndA^ S.	1997	KLK3
42	Interaction of the human epididymal protein CD52 (HE5) with epididymal spermatozoa from men and cynomolgus monkeys. (9291477)	Yeung C.H.... Cooper T.G.	1997	CD52
43	Transbilayer motion of spin-labelled phospholipids in the plasma membrane of epididymal and ejaculated ram spermatozoa. (9370971)	Muller K.... Herrmann A.	1997	ATP8A1
44	Transient appearance of CRES protein during spermatogenesis and caput epididymal sperm maturation. (7619504)	Cornwall G.A.... Hann S.R.	1995	CST8
45	Immunocytochemical localisation of some lysosomal hydrolases, their presence in luminal fluid and their directional secretion by human epididymal cells in culture. (7781038)	Raczek S.... Cooper T.G.	1995	CTSD
46	Purification and characterization of a novel acrosin-like enzyme from boar cauda epididymal sperm. (7822268)	Akama K.... Tobita T.	1994	ACR
47	Gene encoding a mammalian epididymal protein. (7696985)	Wang L.F.... Koide S.S.	1994	ZYX
48	A major mRNA of the human epididymal principal cells, HE5, encodes the leucocyte differentiation CDw52 antigen peptide backbone. (8418821)	Kirchhoff C.... Ivell R.	1993	CD52
49	Bovine proacrosin from cauda epididymal sperm: purification, characterization and partial sequencing at N-terminus. (1473607)	NagDas S.K.	1992	ACR
50	Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein. (1584792)	Lundwall A.... Lilja H.	1992	SEMG2

Genes related to epididymitis according to GeneCards:

(show top 50)    (show all 193)

id	Symbol	Description	Score	GeneCards Section Context
1	EDDM3B	epididymal protein 3B	11.1	Transcripts, Publications, Aliases & Descriptions, Proteins (show all 6 sections) Orthologs, Summaries
2	EDDM3A	epididymal protein 3A	11.1	Summaries, Proteins, Orthologs, Transcripts (show all 6 sections) Publications, Aliases & Descriptions
3	ELSPBP1	epididymal sperm binding protein 1	11.1	Summaries, Orthologs, Proteins, Aliases & Descriptions (show all 6 sections) Transcripts, Publications
4	DEFB126	defensin, beta 126	11.1	Publications, Aliases & Descriptions, Summaries
5	CRISP1	cysteine-rich secretory protein 1	11.1	Publications, Aliases & Descriptions, Summaries, Proteins (show all 5 sections) Orthologs
6	CST11	cystatin 11	11.1	Aliases & Descriptions, Summaries
7	EPPIN	epididymal peptidase inhibitor	11.0	Aliases & Descriptions, Summaries, Publications
8	CST8	cystatin 8 (cystatin-related epididymal specific)	11.0	Publications, Transcripts, Aliases & Descriptions, Orthologs
9	GPX5	glutathione peroxidase 5 (epididymal androgen-related protein)	11.0	Proteins, Aliases & Descriptions, Publications, Transcripts
10	TEDDM1	transmembrane epididymal protein 1	11.0	Proteins, Transcripts, Aliases & Descriptions, Orthologs
11	LCN6	lipocalin 6	11.0	Publications, Proteins, Aliases & Descriptions
12	NPC2	Niemann-Pick disease, type C2	11.0	Orthologs, Proteins, Publications, Aliases & Descriptions
13	WFDC2	WAP four-disulfide core domain 2	11.0	Aliases & Descriptions, Publications
14	LOC391600	transmembrane epididymal protein 1 pseudogene	11.0	Aliases & Descriptions
15	TEDDM1P1	transmembrane epididymal protein 1 pseudogene 1	11.0	Aliases & Descriptions
16	EDDM3DP	epididymal protein 3D, pseudogene	11.0	Aliases & Descriptions
17	EDDM3CP	epididymal protein 3C, pseudogene	11.0	Aliases & Descriptions
18	LCN9	lipocalin 9	11.0	Aliases & Descriptions, Publications, Proteins
19	LOC338963	epididymal protein pseudogene	11.0	Transcripts, Aliases & Descriptions
20	SPAG11B	sperm associated antigen 11B	11.0	Expressions, Aliases & Descriptions, Publications
21	LCN8	lipocalin 8	11.0	Proteins, Publications, Aliases & Descriptions
22	SPAG11A	sperm associated antigen 11A	11.0	Aliases & Descriptions
23	DEFB118	defensin, beta 118	11.0	Aliases & Descriptions, Publications
24	BSPH1	binder of sperm protein homolog 1	11.0	Aliases & Descriptions, Publications
25	GPR64	G protein-coupled receptor 64	11.0	Expressions, Aliases & Descriptions, Functions, Publications
26	ADAM7	ADAM metallopeptidase domain 7	11.0	Publications, Aliases & Descriptions
27	ODF1	outer dense fiber of sperm tails 1	11.0	Summaries
28	ODF2	outer dense fiber of sperm tails 2	11.0	Summaries
29	ZNF77	zinc finger protein 77	11.0
30	CD52	CD52 molecule	10.9	Publications
31	SPINT4	serine peptidase inhibitor, Kunitz type 4	10.9	Publications
32	LCN12	lipocalin 12	10.9	Publications, Proteins
33	RNASE9	ribonuclease, RNase A family, 9 (non-active)	10.9	Expressions
34	SPINT3	serine peptidase inhibitor, Kunitz type, 3	10.9	Publications
35	ACOT1	acyl-CoA thioesterase 1	10.9	Publications
36	LCN10	lipocalin 10	10.9	Publications, Proteins
37	CRISP2	cysteine-rich secretory protein 2	10.9	Orthologs, Publications
38	CLDN8	claudin 8	10.9	Publications
39	ROMO1	reactive oxygen species modulator 1	10.9	Publications
40	CST9L	cystatin 9-like	10.9	Publications
41	ACR	acrosin	10.9	Publications
42	SEMG2	semenogelin II	10.9	Publications
43	SPAG4	sperm associated antigen 4	10.9	Proteins
44	SPINK8	serine peptidase inhibitor, Kazal type 8 (putative)	10.9	Publications
45	UBE2NL	ubiquitin-conjugating enzyme E2N-like	10.9	Publications
46	DCXR	dicarbonyl/L-xylulose reductase	10.9	Publications
47	SLC46A2	solute carrier family 46, member 2	10.9	Publications
48	CLDN7	claudin 7	10.9	Publications
49	TPRA1	transmembrane protein, adipocyte asscociated 1	10.9	Publications
50	PRSS21	protease, serine, 21 (testisin)	10.9	Publications

Pathways related to epididymitis according to GeneDecks:

(show all 13)

id	Pathway	Score	Top Affiliating Genes
1	Leukocyte transendothelial migration20	10.7	CLDN2, CLDN4, CLDN7, CLDN1, CLDN10, CLDN3
2	Tight junction20	10.7	CLDN7, CLDN4, CLDN1, CLDN2, CLDN10, CLDN3
3	Cell adhesion molecules (CAMs)20	10.7	CLDN3, CLDN2, CLDN4, CLDN7, CLDN1, CLDN10
4	Cell adhesion Tight junctions10	10.6	CLDN8, CLDN3, CLDN7, CLDN4, CLDN2, CLDN1
5	Cell adhesion_Tight junctions41	10.5	CLDN8, CLDN3, CLDN1, CLDN4, CLDN2, CLDN7
6	Regulation of CFTR activity (norm and CF)41	10.2	FLNA, ANXA5, GNB2L1, SLC9A3R1, PRKAB1, PRKAG1
7	Hepatitis C20	10.2	CLDN1, TNF, IL8, CLDN8, CLDN2, CLDN4
8	Response to elevated platelet cytosolic Ca2+38	10.1	SOD1, PFN1, CLU, SERPING1, SERPINA1
9	Disease38	10.0	KLK3, PDIA6, TTR, CUX1, EXOC3, CAMP
10	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics34	9.8	ESR1, ESR2, CYP19A1
11	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.2	AR, CYP27B1, CYP19A1, TNF, CA2, IL6
12	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.2	VDR, TNF, IL6, CYP19A1, CYP27B1, AR
13	Tuberculosis20	9.1	TCIRG1, CTSD, CYP27B1, TNF, CAMP, IL6

Compounds related to epididymitis according to GeneDecks:

(show top 50)    (show all 160)

id	Compound	Score	Top Affiliating Genes
1	percoll32	10.6	CKB, CKM, CGB5, FUCA1, CAMP, M6PR
2	glucose32	10.5	VHL, KCNJ11, CKB, CKM, FUCA1, AQP9
3	gnrh32	9.6	CGB5, CFTR, FSHR, CDC25C, AR, GPBAR1
4	n acetylcysteine32	9.5	CLU, CFTR, CEBPB, AR, ANXA5, DUSP19
5	h2o232	9.4	SERPINA1, CLU, CLCN5, CGB5, CFTR, ATP8A1
6	tocopherol32	9.4	RBP4, LPL, GSTP1, CAT, TXN, NR1H2
7	polysaccharide32	9.4	SERPINA1, LPL, CLU, CGB5, AZU1, CEACAM1
8	alpha tocopherol32	9.3	RBP4, LPL, CKM, CAT, TXN, DUSP19
9	aspartate32	9.3	RBP4, VDR, KCNJ11, CKB, CFTR, FURIN
10	oxygen32 18	10.3	RBP4, SERPINA1, CLU, CKB, CKM, P2RX2
11	betacarotene32	9.1	RBP4, LPL, VDR, ANXA5, CAT, TXN
12	diethylstilbestrol32 9 9	11.0	CGB5, AR, ESR1, ESR2, SULT1E1, CYP19A1
13	bisphenol a32	9.0	LPL, AR, ESR1, ESR2, CYP19A1, NR1H2
14	ascorbic acid32 18	10.0	RBP4, VDR, CGB5, CFTR, AR, GSTP1
15	bicalutamide32 42 9 9	11.9	VDR, AR, ESR1, ESR2, CYP19A1, NR1H2
16	cysteine32	8.9	RBP4, SERPINA1, VDR, CLU, CKM, CFTR
17	calcium32 9 18 9	11.9	RBP4, VHL, CLCN3, CLDN2, CLDN4, CLCN5
18	atp32	8.9	CLU, KCNJ11, CKB, CKM, P2RX2, P2RX3
19	glutamine32	8.9	LPL, VDR, KCNJ11, CKB, CFTR, FURIN
20	dopamine32 9 18 9	11.7	RBP4, CLU, CGB5, CFTR, FLNA, GSTP1
21	progesterone32 42 9 18 9	12.7	RBP4, CLU, CKB, CGB5, CEBPB, FURIN
22	cholesterol32 9 18 9	11.7	RBP4, SERPINA1, LPL, CLU, CLDN3, ATP8A1
23	glutamate32	8.7	VDR, CLCN4, CLU, KCNJ11, CKM, AZU1
24	vitamin a32 9 18 9	11.6	RBP4, SERPINA1, LPL, VDR, CGB5, AR
25	resveratrol32 9 18 9	11.5	VDR, CDC25C, AR, ANXA5, ESR1, ESR2
26	fibrinogen32	8.2	SERPINA5, SERPINA1, CLU, CGB5, CEBPB, FURIN
27	butyrate32	8.2	VDR, CLU, CFTR, GSTP1, IL8, ANXA5
28	adenylate32	8.2	RBP4, LPL, VDR, CKM, CGB5, CFTR
29	superoxide32 18	9.2	CLCN3, CLU, CGB5, AZU1, FURIN, CDC25C
30	testosterone32 9 18 9	11.1	LPL, VDR, CLU, CGB5, CFTR, CEBPB
31	creatinine32	8.1	RBP4, SERPINA1, VDR, CLCN5, CKB, CKM
32	vitamin d32	8.0	LPL, VDR, CLU, CKB, CFTR, CEBPB
33	tyrosine32	8.0	SERPINA1, VHL, CLDN4, CLU, CGB5, AZU1
34	dihydrotestosterone32 9 18 9	11.0	LPL, VDR, CLU, CGB5, AR, ESR1
35	alanine32	7.9	RBP4, SERPING1, VDR, CKB, CFTR, CEACAM1
36	arginine32	7.8	VDR, KCNJ11, CKM, CGB5, AZU1, FURIN
37	doxorubicin32 34 9 9	10.7	CLU, CGB5, CFTR, CDC25C, AR, GSTP1
38	paraffin32	7.7	SERPINA1, CLU, CGB5, CFTR, AR, GSTP1
39	cyclosporin a32 42	8.5	LPL, VDR, CGB5, CFTR, IL6, IL8
40	pge232	7.3	LPL, VDR, CGB5, CFTR, CEBPB, FSHR
41	lipid32	7.3	PCTP, RBP4, SERPINA1, LPL, CLU, CKM
42	actinomycin d32	7.1	VHL, VDR, CLU, CGB5, CFTR, CEBPB
43	lactate32	7.1	RBP4, LPL, CLU, CKB, CKM, CGB5
44	vegf32	6.9	VHL, CLU, CLDN3, CGB5, AZU1, CEACAM1
45	cycloheximide32	6.8	LPL, VDR, CLU, CKB, CGB5, CEBPB
46	genistein32 9 18 9	9.7	LPL, VDR, CGB5, CFTR, CEBPB, CDC25C
47	dexamethasone32 42 34 9 9	10.5	RBP4, LPL, VDR, CLDN4, CLU, CGB5
48	retinoic acid32 42 18	8.4	RBP4, VDR, CLU, CGB5, AZU1, CFTR
49	estrogen32	6.3	RBP4, SERPINA1, VHL, LPL, VDR, CLDN4
50	serine32	5.4	BTRC, RBP4, SEMG2, SERPINA5, SERPINA1, SERPING1

Cellular components related to epididymitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	tight junction	GO:005923	10.6	CLDN8, CLDN10, CLDN1, CLDN7, CLDN4, CLDN2
2	melanosome	GO:042470	10.1	PDIA6, YWHAZ, ATP6V1B2, ATP6V0A1, HSP90B1, CTSD
3	cytosol	GO:005829	7.7	PPP1CC, RSPH1, ACOT1, HIF1A, DGKQ, PSMB7
4	extracellular space	GO:005615	7.4	ACE, EDDM3A, COL18A1, CRISP2, CRISP1, TTR
5	extracellular region	GO:005576	7.4	EPPIN, EDDM3B, KLK3, LTF, RNASE9, COL18A1

Biological processes related to epididymitis according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	single fertilization	GO:007338	10.9	ACR, SLC22A16, ELSPBP1, MFGE8, BSPH1, LCN6
2	calcium-independent cell-cell adhesion	GO:016338	10.8	CLDN2, CLDN8, CLDN3, CLDN10, CLDN1, CLDN7
3	purinergic nucleotide receptor signaling pathway	GO:035590	10.8	P2RX4, P2RX2, P2RX6, P2RX3
4	response to ATP	GO:033198	10.6	P2RX3, KCNJ11, DGKQ, P2RX4, P2RX2
5	defense response to bacterium	GO:042742	10.6	CAMP, DEFB118, EPPIN, ROMO1, CST11, DEFB126
6	transport	GO:006810	10.2	AQP9, TTR, CLCN3, CLCN4, CLCN5, LCN10
7	interaction with host	GO:051701	10.2	ATP6V1B2, CAMP, LTF, TCIRG1, ATP6V0A1
8	protein heterooligomerization	GO:051291	10.0	SEPT11, P2RX6, PRKAG1, PRKAB1, P2RX2, PRKAA1
9	phagosome maturation	GO:090382	10.0	ATP6V1B2, ATP6V0A1, CAMP, LTF, TCIRG1
10	fusion of sperm to egg plasma membrane	GO:007342	9.8	ADAM2, SERPINA5, SPAM1, CRISP1
11	platelet activation	GO:030168	9.5	SERPING1, SERPINA1, SOD1, DGKQ, PFN1, GNA15
12	spermatogenesis	GO:007283	9.4	SERPINA5, PRKAG1, DEFB118, NOTCH1, SPAG4, SPAG9
13	response to hypoxia	GO:001666	9.4	HSP90B1, P2RX3, P2RX2, CLDN3, CAT, SERPINA1

Molecular functions related to epididymitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:005198	10.7	CLDN7, CLDN1, CLDN10, CLDN3, CLDN8, COL18A1
2	extracellular ATP-gated cation channel activity	GO:004931	10.4	P2RX2, P2RX3, P2RX4, P2RX6
3	purinergic nucleotide receptor activity	GO:001614	10.2	P2RX2, P2RX6, P2RX4, P2RX3
4	serine-type endopeptidase inhibitor activity	GO:004867	9.8	EPPIN, WFDC2, PEBP1, SPINT3, SPINK8, SPINT4
5	identical protein binding	GO:042802	9.8	P2RX2, P2RX6, GLUD1, ESR1, TNF, CLDN8
6	protein binding	GO:005515	4.4	ACE, KLK3, ZYX, ACR, LTF, PDIA6