MCID: EPD018
MIFTS: 30

Epididymo-Orchitis

Categories: Reproductive diseases

Aliases & Classifications for Epididymo-Orchitis

MalaCards integrated aliases for Epididymo-Orchitis:

Name: Epididymo-Orchitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9401
ICD10 33 N45 N45.3
ICD9CM 35 604 604.90
UMLS 69 C0149881

Summaries for Epididymo-Orchitis

MalaCards based summary : Epididymo-Orchitis is related to acute gonococcal epididymo-orchitis and orchitis. An important gene associated with Epididymo-Orchitis is PDCD11 (Programmed Cell Death 11), and among its related pathways/superpathways are DNA Damage/Telomere Stress Induced Senescence and Signaling pathways regulating pluripotency of stem cells. Affiliated tissues include prostate, testis and kidney.

Related Diseases for Epididymo-Orchitis

Diseases related to Epididymo-Orchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
id Related Disease Score Top Affiliating Genes
1 acute gonococcal epididymo-orchitis 12.2
2 orchitis 11.1
3 mumps 10.4
4 brucellosis 10.4
5 prostatitis 10.4
6 tuberculosis 10.3
7 urethritis 10.2
8 testicular infarct 10.2
9 influenza 10.2
10 tuberculous epididymitis 10.1
11 posterior urethral valves 10.1
12 bacteremia 10.0
13 leukemia 10.0
14 scrub typhus 10.0
15 relapsing polychondritis 10.0
16 adenocarcinoma 10.0
17 melioidosis 9.9
18 prostate cancer 9.9
19 kawasaki disease 9.9
20 neutropenia 9.9
21 severe congenital neutropenia 9.9
22 inguinal hernia 9.9
23 salmonellosis 9.9
24 parotitis 9.9
25 lymphoblastic leukemia 9.9
26 imperforate anus 9.9
27 choroiditis 9.9
28 choledocholithiasis 9.9
29 dementia 9.9
30 histoplasmosis 9.9
31 leiomyosarcoma 9.9
32 nocardiosis 9.9
33 prostate adenocarcinoma 9.9
34 acute pancreatitis 9.9
35 teratoma 9.9
36 purpura 9.9
37 seminoma 9.9
38 pancreatitis 9.9
39 herpes simplex 9.9
40 meningitis 9.9
41 hydrocele 9.9
42 candida glabrata 9.9
43 duplication of urethra 9.9
44 haemophilus influenzae 9.9
45 syndrome of inappropriate antidiuretic hormone 9.9
46 aneurysm 9.9
47 diabetes insipidus 6.7 ACVR1B ACVR2B CCT5 CRP INHBB PDCD11

Comorbidity relations with Epididymo-Orchitis via Phenotypic Disease Network (PDN):


Acute Cystitis Bladder Neck Obstruction
Ischemic Heart Disease Prostate Cancer
Prostatic Hypertrophy Prostatitis
Urethral Stricture

Graphical network of the top 20 diseases related to Epididymo-Orchitis:



Diseases related to Epididymo-Orchitis

Symptoms & Phenotypes for Epididymo-Orchitis

Drugs & Therapeutics for Epididymo-Orchitis

Search Clinical Trials , NIH Clinical Center for Epididymo-Orchitis

Genetic Tests for Epididymo-Orchitis

Anatomical Context for Epididymo-Orchitis

MalaCards organs/tissues related to Epididymo-Orchitis:

39
Prostate, Testis, Kidney, Testes, Bone, Monocytes, T Cells

Publications for Epididymo-Orchitis

Articles related to Epididymo-Orchitis:

(show top 50) (show all 260)
id Title Authors Year
1
Granulomatous epididymo-orchitis: diagnosis by fine needle aspiration. ( 28534708 )
2017
2
Coexistent duplication of urethra and a refluxing ectopic ureter presenting as recurrent epididymo-orchitis in a child. ( 28928250 )
2017
3
Retrospective review of the management of epididymo-orchitis in a London-based level 3 sexual health clinic: an audit of clinical practice. ( 28201951 )
2017
4
Testicular Metastasis From Prostatic Adenocarcinoma Presenting as Recurrent Epididymo-orchitis. ( 28760557 )
2017
5
The 2016 European guideline on the management of epididymo-orchitis. ( 28632112 )
2017
6
Severe Acute Epididymo-Orchitis Complicated with Abscess and Testicular Necrosis - Case Report. ( 28246649 )
2017
7
Inferno sign in epididymo-orchitis. ( 28647767 )
2017
8
Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. ( 28205525 )
2017
9
Patients with Epididymo-Orchitis and Meteorological Impact in Taiwan: A Nationwide Population-Based Study. ( 28316630 )
2017
10
First description of herpes simplex virus type 1 epididymo-orchitis: A new clinical form of herpes simplex virus infection during septic shock? ( 27672563 )
2016
11
Unmasking immune reconstitution inflammatory syndrome: a report of tuberculous epididymo-orchitis mimicking a testicular tumour in a Caucasian AIDS patient. ( 27222288 )
2016
12
Co-administration of ginseng and ciprofloxacin ameliorates epididymo-orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats. ( 27246506 )
2016
13
Testicular infarction and rupture: an uncommon complication of epididymo-orchitis. ( 27165751 )
2016
14
Tuberculous epididymo-orchitis masquerading as acute scrotum. ( 26847806 )
2016
15
A case of a male presenting with fever, parotitis, epididymo-orchitis, and kidney injury. ( 27012169 )
2016
16
Acute Epididymo-orchitis-Related Global Testicular Infarction: Clinical and Ultrasound Findings With an Emphasis on the Juxta-epididymal String-of-Bead Sign. ( 27556195 )
2016
17
ASSOCIATION OF MEAN PLATELET VOLUME AND THE MONOCYTE/LYMPHOCYTE RATIO WITH BRUCELLA-CAUSED EPIDIDYMO-ORCHITIS. ( 27405128 )
2016
18
Emphysematous epididymo-orchitis as a camouflage of prostate invasion secondary to rectum cancer: A case report. ( 27472731 )
2016
19
The clinical and laboratory characteristics, treatments, and outcomes of patients with Brucella epididymo-orchitis (BEO) compared to those without BEO. ( 27966338 )
2016
20
A Case of Epididymo-orchitis after intravesical bacille Calmette-GuAcrin therapy for superficial bladder carcinoma in a patient with latent tuberculosis infection. ( 27257433 )
2016
21
Ameliorating Effect of Ginseng on Epididymo-Orchitis Inducing Alterations in Sperm Quality and Spermatogenic Cells Apoptosis following Infection by Uropathogenic Escherichia coli in Rats. ( 27602327 )
2016
22
Surgically Confirmed Intra- and Extratesticular Hematoma Clinically Mimicing Epididymo-Orchitis and Radiologically Mimicing Traumatic Torsion. ( 26600877 )
2015
23
BehAset's Disease Detecting by Attacks of Recurrent Epididymo-Orchitis: Case Reports. ( 26571326 )
2015
24
Distribution of Epididymal Involvement in Mumps Epididymo-orchitis. ( 26014328 )
2015
25
Testicular loss following bacterial epididymo-orchitis: Case report and literature review. ( 25844104 )
2015
26
Unilateral Tuberculous Epididymo- Orchitis with Scrotal Fistula: a Case Report. ( 26351479 )
2015
27
Intratesticular and scrotal wall air: Emphysematous epididymo-orchitis or Fournier's gangrene: A dilemma. ( 25709172 )
2015
28
Emphysematous epididymo-orchitis. ( 25709173 )
2015
29
Tuberculous epididymo-orchitis: A difficult diagnosis. ( 25626956 )
2015
30
IgG4-related epididymo-orchitis associated with bladder cancer: possible involvement of BAFF/BAFF-R interaction in IgG4-related urogenital disease. ( 24261777 )
2014
31
A case of childhood Brucellosis with neurological involvement and epididymo-orchitis. ( 25500664 )
2014
32
FDG PET/CT Images Demonstrating Epididymo-Orchitis in a Patient With HIV, Acute Kidney Injury and Known Epididymo-Orchitis on Scrotal Ultrasound. ( 25247269 )
2014
33
Isolation of Actinobacillus seminis from a goat with clinical epididymo-orchitis in Brazil. ( 24948932 )
2014
34
Spermatic cord abscess: a rare complication of epididymo-orchitis, the diagnosis and management. ( 25096656 )
2014
35
Epididymo-orchitis: a rare manifestation of scrub typhus in a child. ( 24717207 )
2014
36
Synchronous infection of the aorta and the testis: emphysematous epididymo-orchitis, abdominal aortic mycotic aneurysm, and testicular artery pseudoaneurysm diagnosed by use of MDCT. ( 24737146 )
2014
37
Brucellar epididymo-orchitis: a retrospective multicenter study of 28 cases and review of the literature. ( 25457303 )
2014
38
Imaging in emphysematous epididymo-orchitis: A rare cause of acute scrotum. ( 25114397 )
2014
39
Midline Intraprostatic Cyst: An Unusual Aetiology of Urinary Tract Infection and Epididymo-orchitis. ( 24254245 )
2013
40
Necrosis is the dominant cell death pathway in uropathogenic Escherichia coli elicited epididymo-orchitis and is responsible for damage of rat testis. ( 23301002 )
2013
41
Neurovascular sparing vas clipping: last option for recurrent epididymo-orchitis in urethrovasal reflux due to urethral injury. ( 24265039 )
2013
42
Managing epididymo-orchitis in general practice. ( 23724748 )
2013
43
Post-intravesical BCG epididymo-orchitis: Case report and a review of the literature. ( 23856256 )
2013
44
Epididymo-Orchitis: An Unusual Manifestation of Scrub Typhus. ( 23389349 )
2013
45
Early regression of spermatogenesis in boars of an inbred Duroc strain caused by incident orchitis/epididymo-orchitis. ( 23428633 )
2013
46
Epididymo-orchitis: an unusual manifestation of salmonellosis. ( 22138654 )
2012
47
Post-prostate biopsy infection with Escherichia coli ST131 leading to epididymo-orchitis and meningitis caused by Gram-negative bacilli. ( 23015671 )
2012
48
"BCGitis": A rare case of tuberculous epididymo-orchitis following intravesical Bacillus Calmette-GuAcrin therapy. ( 23372864 )
2012
49
Exceptionally high titres in atypical presentation of occult epididymo-orchitis due to brucellosis. ( 22194340 )
2012
50
Isolated tuberculous epididymo-orchitis: an unusual presentation of tuberculosis. ( 22240436 )
2012

Variations for Epididymo-Orchitis

Expression for Epididymo-Orchitis

Search GEO for disease gene expression data for Epididymo-Orchitis.

Pathways for Epididymo-Orchitis

GO Terms for Epididymo-Orchitis

Cellular components related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.16 CCT5 TCP1
2 chaperonin-containing T-complex GO:0005832 8.96 CCT5 TCP1
3 zona pellucida receptor complex GO:0002199 8.62 CCT5 TCP1

Biological processes related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 signal transduction by protein phosphorylation GO:0023014 9.54 ACVR1B ACVR2B
2 chaperone-mediated protein folding GO:0061077 9.52 CCT5 TCP1
3 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.51 ACVR1B INHBB
4 regulation of signal transduction GO:0009966 9.49 ACVR1B ACVR2B
5 binding of sperm to zona pellucida GO:0007339 9.48 CCT5 TCP1
6 toxin transport GO:1901998 9.46 CCT5 TCP1
7 positive regulation of telomere maintenance via telomerase GO:0032212 9.43 CCT5 TCP1
8 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.4 ACVR1B ACVR2B
9 de novo protein folding GO:0006458 9.37 CCT5 TCP1
10 positive regulation of telomerase RNA localization to Cajal body GO:1904874 9.32 CCT5 TCP1
11 positive regulation of establishment of protein localization to telomere GO:1904851 9.26 CCT5 TCP1
12 positive regulation of protein localization to Cajal body GO:1904871 9.16 CCT5 TCP1
13 positive regulation of activin receptor signaling pathway GO:0032927 8.96 ACVR1B ACVR2B
14 activin receptor signaling pathway GO:0032924 8.8 ACVR1B ACVR2B INHBB

Molecular functions related to Epididymo-Orchitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 9.32 ACVR1B ACVR2B
2 protein binding involved in protein folding GO:0044183 9.26 CCT5 TCP1
3 signal transducer, downstream of receptor, with serine/threonine kinase activity GO:0004702 9.16 ACVR1B ACVR2B
4 activin binding GO:0048185 8.96 ACVR1B ACVR2B
5 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.62 ACVR1B ACVR2B

Sources for Epididymo-Orchitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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