MCID: EPD019
MIFTS: 34

Epidural Neoplasm

Categories: Neuronal diseases, Cancer diseases

Aliases & Classifications for Epidural Neoplasm

MalaCards integrated aliases for Epidural Neoplasm:

Name: Epidural Neoplasm 12 14
Epidural Neoplasms 42 69
Extradural Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3618
MeSH 42 D015174
NCIt 47 C3019
UMLS 69 C0014536

Summaries for Epidural Neoplasm

MalaCards based summary : Epidural Neoplasm, also known as epidural neoplasms, is related to cervical endometrioid adenocarcinoma and blake pouch cyst. An important gene associated with Epidural Neoplasm is PTCHD3 (Patched Domain Containing 3), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and B Cell Development Pathways. The drugs Bupivacaine and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and lung, and related phenotypes are hematopoietic system and immune system

Related Diseases for Epidural Neoplasm

Diseases related to Epidural Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
id Related Disease Score Top Affiliating Genes
1 cervical endometrioid adenocarcinoma 10.7 BCL6 CD5
2 blake pouch cyst 10.7 BCL6 CD5
3 gastric small cell carcinoma 10.7 BCL6 PTPRC
4 pediatric lymphoma 10.7 BCL6 CD5
5 thrombocytopenia 10.7 BCL6 PTPRC
6 lipid-cell variant infiltrating bladder urothelial carcinoma 10.7 KRT5 TP53
7 hypochondriasis 10.7 ANKRD11 CD6
8 small intestine leiomyoma 10.7 KRT5 TP53
9 anal squamous cell carcinoma 10.7 KRT5 TP53
10 plummer vinson syndrome 10.7 BCL6 PTPRC
11 cribriform carcinoma 10.6 KRT5 PTPRC
12 bagatelle cassidy syndrome 10.6 CD5 TP53
13 thyroid cancer, anaplastic 10.6 CD5 CD99
14 colon squamous cell carcinoma 10.6 ANKRD11 KRT5
15 pylorus cancer 10.6 BCL6 TP53
16 hepatic osteogenic sarcoma 10.6 CD5 TP53
17 female breast axillary tail cancer 10.6 CD99 KRT5
18 familial lipoprotein lipase deficiency 10.6 CD6 KRT5
19 lobular neoplasia 10.6 CD99 KRT5
20 endodermal sinus tumor 10.6 PTPRC TP53
21 multiple carboxylase deficiency 10.6 CD6 TP53
22 paraneoplastic polyneuropathy 10.5 BCL6 PTPRC
23 lung benign neoplasm 10.5 CD99 PTPRC
24 hypersensitivity reaction type iii disease 10.5 KRT5 TP53
25 malignant giant cell tumor 10.5 PTPRC TP53
26 tang hsi ryu syndrome 10.5 BCL6 TNFRSF8
27 malignant peritoneal solitary fibrous tumor 10.5 FUT4 KRT5
28 duodenal ulcer 10.5 CD5 TP53
29 estrogen-receptor positive breast cancer 10.4 BCL6 CD5 PTPRC
30 spondyloepimetaphyseal dysplasia, isidor type 10.4 CD99 PTPRC
31 brain stem infarction 10.4 PTPRC TNFRSF8
32 marinesco-sjogren-like syndrome 10.4 TNFRSF8 TP53
33 plasmodium ovale malaria 10.4 CD5 KRT5 TP53
34 hip subluxation 10.4 KRT5 TP53
35 fallopian tube squamous cell carcinoma 10.4 KRT5 PTPRC TP53
36 short-rib thoracic dysplasia 12 10.4 PTPRC TNFRSF8
37 cd3delta deficiency 10.4 CD5 PTPRC
38 urinary bladder inverted papilloma 10.4 KRT19 PTPRC
39 olivopontocerebellar atrophy deafness 10.4 KRT19 KRT5
40 urethra clear cell adenocarcinoma 10.4 KRT19 KRT5
41 megakaryocytic leukemia 10.3 BCL6 CD5 TP53
42 delta chain disease 10.3 FUT4 PTPRC
43 vaginal adenoma 10.3 KRT19 KRT5
44 ritter's disease 10.3 KRT19 TP53
45 childhood oligodendroglioma 10.3 KRT5 TP53
46 juxtacortical osteosarcoma 10.3 CD99 PTPRC
47 inner ear cancer 10.3 FUT4 TNFRSF8
48 avian influenza 10.2 CD5 FUT4 KRT5
49 villoglandular endometrial endometrioid adenocarcinoma 10.2 BCL6 CD5 TNFRSF8
50 vestibular disease 10.2 KRT5 TP53

Graphical network of the top 20 diseases related to Epidural Neoplasm:



Diseases related to Epidural Neoplasm

Symptoms & Phenotypes for Epidural Neoplasm

MGI Mouse Phenotypes related to Epidural Neoplasm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 ANKRD11 BCL6 CD5 CD6 DNTT FUT4
2 immune system MP:0005387 9.61 FUT4 PTPRC TNFRSF8 TP53 ANKRD11 BCL6
3 no phenotypic analysis MP:0003012 9.1 BCL6 CD5 KRT19 KRT5 PTPRC TP53

Drugs & Therapeutics for Epidural Neoplasm

Drugs for Epidural Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 151)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2180-92-9, 38396-39-3 2474
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 437-38-7 3345
3
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 57-27-2 5288826
4
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
5
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
6
Ketorolac Approved Phase 4,Phase 2,Phase 1 74103-06-3, 66635-83-4 3826
7
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
8
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2 51-43-4 5816
9 Racepinephrine Approved Phase 4,Phase 3,Phase 2
10
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
11
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
12
Sevoflurane Approved, Vet_approved Phase 4,Phase 3 28523-86-6 5206
13
Sufentanil Approved, Investigational Phase 4,Phase 3 56030-54-7 41693
14
Levobupivacaine Approved Phase 4 27262-47-1 92253
15
Lidocaine Approved, Vet_approved Phase 4,Phase 2 137-58-6 3676
16
Clonidine Approved Phase 4 4205-90-7 2803
17
Peppermint Approved, Nutraceutical Phase 4
18 tannic acid Approved, Nutraceutical Phase 4
19 Adjuvants, Anesthesia Phase 4,Phase 3
20 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Analgesics, Opioid Phase 4,Phase 3,Phase 2
22 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Anesthetics, General Phase 4,Phase 3,Phase 2
24 Anesthetics, Intravenous Phase 4,Phase 3,Phase 2
25 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1
26 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Narcotics Phase 4,Phase 3,Phase 2,Early Phase 1
28 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Ketorolac Tromethamine Phase 4,Phase 2
32 Epinephryl borate Phase 4,Phase 3,Phase 2
33 Defensins Phase 4
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 1,Phase 2,Early Phase 1
35 Antirheumatic Agents Phase 4,Phase 1,Phase 2,Early Phase 1
36 Cyclooxygenase Inhibitors Phase 4
37 Liver Extracts Phase 4,Phase 3
38 Pirinitramide Phase 4
39 Antipyretics Phase 4
40 Cola Nutraceutical Phase 4,Phase 1,Phase 2
41
Hydromorphone Approved, Illicit Phase 3,Phase 2 466-99-9 5284570
42 Ramosetron Approved Phase 3 132036-88-5
43
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
44
Ketamine Approved, Vet_approved Phase 2, Phase 3 6740-88-1 3821
45
Pancrelipase Approved Phase 3 53608-75-6
46 Nefopam Investigational Phase 3 13669-70-0
47 Hypnotics and Sedatives Phase 3,Phase 2
48 Anesthetics, Inhalation Phase 3,Phase 2
49 Antiemetics Phase 3
50 Autonomic Agents Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 114)

id Name Status NCT ID Phase Drugs
1 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4 gum
2 Cardiac Arrhythmias in Patients Undergoing Kidney Cancer Surgery Depending on the Anaesthesia Method Completed NCT02988219 Phase 4 Bupivacaine-fentanyl
3 Comparison of the Effects of Continuous Epidural Analgesia and Continuous Intravenous Analgesia on Postoperative Bowel Movement in Patients Undergoing Laparoscopic Gastrectomy Completed NCT02458573 Phase 4
4 Comparison of the Analgesic Effect Between Intrathecal Morphine and IV-fentanyl Patient Controlled Analgesia (ITM-IVPCA) and Epidural PCA (PCEA) in Patients Undergoing Gastrectomy -Randomized Allocation Study- Completed NCT01234272 Phase 4 morphine;Ropivacaine
5 The Effect of Combined General/Epidural Anesthesia Versus General Anesthesia on Diaphragmatic Function Completed NCT01547416 Phase 4 epidural 250mL of 0.2% ropivacaine and 2 μg/mL of fentanyl, 5 mL/hr continuous infusion and 0.5 mL bolus dose;no epidural drug administered
6 Oxidative Stress Markers in Open and Laparoscopic Colectomy for Cancer Completed NCT00928928 Phase 4
7 Inflammatory Response in Laparoscopic and Open Colectomy Completed NCT00942461 Phase 4
8 Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression Completed NCT00634426 Phase 4
9 Antinociceptive Modalities on Ischemia Reperfusion Injury Completed NCT01932918 Phase 4 Patient controlled analgesia
10 Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery Recruiting NCT02314871 Phase 4 Piritramide;Morphine
11 Supplementary Epidural Analgesia in Video-Assisted Thoracic Surgery (VATS) - The SEAVATS Study Recruiting NCT02359175 Phase 4 Bupivacaine in epidural catheter;Fentanyl in epidural catheter;Placebo (for Bupivacain and Fentanyl i epidural catheter);Oral Paracetamol;Oral NSAID;Oral opioids;Placebo (for oral opioids)
12 Postoperative Pain Management After Minimally Invasive Esophagectomy Recruiting NCT02042313 Phase 4
13 Programmed Intermittent Bolus Dosing Versus Continuous Epidural Infusion for Epidural Analgesia in Abdominal Surgery. Recruiting NCT03307174 Phase 4 Bupivacaine;Fentanyl
14 Recovery and Analgesia After Surgery for Gynecological Cancer Active, not recruiting NCT02026687 Phase 4
15 Doppler Ultrasonography Assessed Vascular Changes During Anesthesia Induction Not yet recruiting NCT03302221 Phase 4 0.5% ropivacaine paravertebral block;1% lidocaine epidural block;Dexmedetomidine Group infusion
16 RANDOMISED STUDY OF EPIDURAL VS MPCA MORPHINE VS TAPP IN LAPAROSCOPIC SIGMOIDECTOMY Unknown status NCT01825993 Phase 3 L-BUPIVACAINE ; MORPHINE;MORPHINE
17 Epidural Hydromorphone Compared With Hydromorphone Infusion in Treating Patients With Prostate Cancer Undergoing Radical Prostatectomy Completed NCT00003115 Phase 3 hydromorphone hydrochloride
18 Patient-Controlled Epidural Analgesia (PCEA) for Patients Who Have Had Major Open Gynecologic Surgery Completed NCT00136682 Phase 3 patient-controlled epidural analgesia (PCEA);patient-controlled intravenous analgesia (PCA)
19 The Comparison Between Epidural and Intravenous Patient-controlled Analgesia for Laparoscopic Gastrectomy Completed NCT02444897 Phase 3 Epidural PCA Ropivacaine;IV PCA Fentanyl+nefopam+Ramosetron
20 Effects of Anesthetic Technique on Immune and Inflammatory Systems Following Radical Prostatectomy Completed NCT01367418 Phase 3 Patient controlled analgesia (PCA);Thoracic Epidural Analgesia (TEA)
21 Acupuncture for Post-Thoracotomy Pain Completed NCT00142532 Phase 3
22 Restricted Intravenous Fluid Regime Effects on Immunological Indicators of Elderly Patients Operated for Abdominal Cancer Completed NCT01399814 Phase 3
23 Epidural Versus Patient-controlled Analgesia for Reduction in Long-term Mortality Following Colorectal Cancer Surgery Recruiting NCT01318161 Phase 3 Ropivacaine + opioid epidurally;Morphine
24 Epidural Anesthesia Within an Enhanced Recovery Pathway in Reducing Pain in Patients Undergoing Gynecologic Surgery Recruiting NCT02423876 Phase 3 Epidural analgesia
25 Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection Recruiting NCT02523443 Phase 3
26 Regional Anesthesia and Breast Cancer Recurrence Recruiting NCT00418457 Phase 3 General anesthesia and opioids;Regional analgesia and propofol
27 Trial of Thoracic Epidural Analgesia Versus Four-Quadrant Transversus Abdominus Plane Block in Oncologic Open Liver Surgery Recruiting NCT03214510 Phase 3 Bupivacaine;Liposomal Bupivacaine;Hydromorphone
28 Dexmedetomidine,Ketamine and Their Combination to Bupivicaine on Thoracic Epidural Analgesia Recruiting NCT03063671 Phase 2, Phase 3 Ketamine, bupivacine,dexmedetomidine
29 Postoperative Thoracic Epidural Analgesia Versus Intravenous Patient-Controlled Analgesia For Liver and/or Pancreas Active, not recruiting NCT01438476 Phase 3
30 Regional Anesthesia and Endometrial Cancer Recurrence Withdrawn NCT00531349 Phase 3 Sevoflurane
31 Thoracoscopic Lobectomy Using Nonintubated Anesthesia Versus Intubated General Anesthesia for Lung Cancer Patients Unknown status NCT01533233 Phase 1, Phase 2
32 Spine Stereotactic Body Radiation Therapy for Metastatic Epidural Spinal Cord Compression Unknown status NCT01826058 Phase 2
33 Peri-Operative Management of Patients Undergoing Laparoscopic Colorectal Surgery Unknown status NCT00747292 Phase 1, Phase 2
34 Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection. Unknown status NCT02086123 Phase 2
35 A Randomized Study of the Efficacy of Low Venous Pressure General Anesthesia Versus Combined Spinal-Epidural Anesthesia in Decreasing Blood Loss During Prostate Surgery Completed NCT00200187 Phase 2
36 Xenon Combined With Intraoperative Thoracic Epidural Analgesia Completed NCT01696630 Phase 2 Xenon;Desflurane
37 Comparison of Efficacy of Paravertebral and Epidural Analgesia After Videothoracoscopic Lung Lobectomy Completed NCT02040662 Phase 2
38 Efficacy of Epidural Etanercept in the Treatment of Sciatica Completed NCT00364572 Phase 1, Phase 2 epidural injection of etanercept;placebo (control procedure)
39 Epidural Analgesia Vs Rectus Sheath Block: Postoperative Analgesia and Proinflammatory Cytokines Completed NCT03074097 Phase 2 Bupivacaine 0.125%;Bupivacaine 0.25%
40 Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine Completed NCT01155440 Phase 2 Lidocaine
41 Comparison of Thoracoscopic Talc Pleurodesis by Thoracic Epidural or General Anesthesia Completed NCT01469728 Phase 2
42 Safety and Efficacy of Intrathecal Morphine in Children Completed NCT03120403 Phase 2
43 Early Recovery After Surgery (ERAS) Versus Conventional Protocol After Laparoscopic Gastrectomy Completed NCT01938313 Phase 2
44 Thermal Ablation and Stereotactic Spine Radiosurgery (SSRS) Recruiting NCT02713269 Phase 2
45 Enhanced Recovery After Surgery (ERAS) on Laparoscopy-assisted Distal Gastrectomy Recruiting NCT03016026 Phase 2
46 Clinical Trial Comparing Dose-intensified SBRT With Conventional Radiation Therapy for Spinal Metastases Recruiting NCT02800551 Phase 2
47 HDR Brachytherapy vs. LDR Brachytherapy Monotherapy in Localized Prostate Cancer Active, not recruiting NCT02628041 Phase 2
48 Ultrasound-guided PVB Terminated NCT01842698 Phase 2
49 Intra-arterial Chemotherapy for Spinal Metastases Recruiting NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
50 Study to Evaluate Safety and MTD of Epidural Resiniferatoxin Injection for Treatment of Intractable Cancer Pain Recruiting NCT03226574 Phase 1 Resiniferatoxin

Search NIH Clinical Center for Epidural Neoplasm

Cochrane evidence based reviews: epidural neoplasms

Genetic Tests for Epidural Neoplasm

Anatomical Context for Epidural Neoplasm

MalaCards organs/tissues related to Epidural Neoplasm:

39
Colon, Liver, Lung, Spinal Cord, Prostate, Breast, Nk Cells

Publications for Epidural Neoplasm

Articles related to Epidural Neoplasm:

id Title Authors Year
1
Evaluation of back pain caused by epidural neoplasm. ( 24573025 )
1993
2
Plain film clues to the diagnosis of spinal epidural neoplasm and infection. ( 8492898 )
1993
3
Identification of epidural neoplasm. Radiography and bone scintigraphy in the symptomatic and asymptomatic spine. ( 2804911 )
1989
4
Disturbance of the circulation in the spinal cord with epidural neoplasm. ( 4069060 )
1985
5
Circulatory disturbance of the spinal cord with epidural neoplasm in rats. ( 3926963 )
1985
6
Experimental spinal cord compression by epidural neoplasm. ( 558545 )
1977

Variations for Epidural Neoplasm

Expression for Epidural Neoplasm

Search GEO for disease gene expression data for Epidural Neoplasm.

Pathways for Epidural Neoplasm

Pathways related to Epidural Neoplasm according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.29 CD6 CD99 PTPRC
2 10.65 BCL6 CD5 PTPRC TNFRSF8

GO Terms for Epidural Neoplasm

Cellular components related to Epidural Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 replication fork GO:0005657 8.62 BCL6 TP53

Biological processes related to Epidural Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of histone deacetylation GO:0031065 8.62 BCL6 TP53

Sources for Epidural Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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