MCID: EPD019
MIFTS: 33

Epidural Neoplasm malady

Categories: Neuronal diseases, Cancer diseases

Aliases & Classifications for Epidural Neoplasm

Aliases & Descriptions for Epidural Neoplasm:

Name: Epidural Neoplasm 12 14
Epidural Neoplasms 42 69
Extradural Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3618
MeSH 42 D015174
NCIt 47 C3019
UMLS 69 C0014536

Summaries for Epidural Neoplasm

MalaCards based summary : Epidural Neoplasm, also known as epidural neoplasms, is related to small intestine leiomyoma and tibial aplasia ectrodactyly hydrocephalus. An important gene associated with Epidural Neoplasm is PTCHD3 (Patched Domain Containing 3), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and B Cell Development Pathways. The drugs Bupivacaine and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Epidural Neoplasm

Diseases related to Epidural Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 small intestine leiomyoma 10.2 KRT5 TP53
2 tibial aplasia ectrodactyly hydrocephalus 10.2 CD5 CD99
3 sclerosing breast papilloma 10.2 KRT5 TP53
4 hemangioma of liver 10.2 PTPRC TP53
5 ethmoid sinus inverted papilloma 10.2 BCL6 PTPRC
6 plexopathy 10.2 CD99 PTPRC
7 coloboma of eyelid 10.2 BCL6 CD5
8 choriocarcinoma of ovary 10.2 KRT5 PTPRC TP53
9 plasmodium ovale malaria 10.2 CD5 KRT5 TP53
10 female breast axillary tail cancer 10.2 CD99 KRT5
11 chronic monocytic leukemia 10.2 ANKRD11 CD6 TP53
12 breast granular cell tumor 10.2 CD99 KRT5
13 marsden nyhan sakati syndrome 10.2 TNFRSF8 TP53
14 pediatric intraocular retinoblastoma 10.1 KRT19 PTPRC
15 myotonic disease 10.1 CD5 FUT4 KRT5
16 barnicoat baraitser syndrome 10.1 CD5 TP53
17 nutritional deficiency disease 10.1 FUT4 TNFRSF8
18 peripheral osteosarcoma 10.1 CD99 PTPRC
19 polydactyly cleft lip palate psychomotor retardation 10.1 BCL6 PTPRC
20 ovarian clear cell malignant adenofibroma 10.1 CD5 KRT19 PTPRC
21 central nervous system vasculitis 10.0 DNTT TP53
22 teebi naguib al awadi syndrome 10.0 BCL6 TNFRSF8
23 melanoma metastasis 10.0 BCL6 CD5 TP53
24 anal carcinoma in situ 10.0 KRT19 TP53
25 subacute delirium 10.0 FUT4 PTPRC TNFRSF8
26 fallopian tube leiomyoma 10.0 FUT4 PTPRC TNFRSF8
27 neuromuscular disease 10.0 FUT4 PTPRC TNFRSF8
28 paranasal sinus cancer 10.0 KRT19 TNFRSF8
29 cerebral arterial disease 10.0 PTPRC TNFRSF8
30 basal ganglia disease 10.0 BCL6 CD5 TNFRSF8
31 malignant pleural solitary fibrous tumor 10.0 KRT19 KRT5 TP53
32 lip cancer 10.0 BCL6 PTPRC TNFRSF8
33 mixed type thymoma 9.9 CD5 DNTT PTPRC
34 ureter transitional cell carcinoma 9.9 BCL6 FUT4 TNFRSF8
35 carnitine-acylcarnitine translocase deficiency 9.9 BCL6 PTPRC TNFRSF8
36 ureter small cell carcinoma 9.9 BCL6 FUT4 TNFRSF8
37 pyloric antrum cancer 9.9 BCL6 TP53
38 penile disease 9.9 BCL6 CD5 PTPRC TNFRSF8
39 ectodermal dysplasia 9.9 BCL6 CD5 TNFRSF8 TP53
40 bladder disease 9.9 BCL6 CD5 TNFRSF8 TP53
41 combined thymoma 9.9 CD5 DNTT KRT5 TP53
42 sensory organ benign neoplasm 9.9 CD5 KRT19 PTPRC TNFRSF8
43 rectum lymphoma 9.9 CD5 KRT19 PTPRC TNFRSF8
44 cranioectodermal dysplasia 1 9.6 CD5 DNTT FUT4 PTPRC TP53
45 chronic venous leg ulcers 9.6 BCL6 CD5 DNTT PTPRC TP53
46 back pain 9.5
47 klippel-trenaunay-weber syndrome 9.5
48 histiocytoma 9.5
49 fibrous histiocytoma 9.5
50 weber syndrome 9.5

Graphical network of the top 20 diseases related to Epidural Neoplasm:



Diseases related to Epidural Neoplasm

Symptoms & Phenotypes for Epidural Neoplasm

MGI Mouse Phenotypes related to Epidural Neoplasm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 TNFRSF8 TP53 ANKRD11 BCL6 CD5 CD6
2 immune system MP:0005387 9.61 ANKRD11 BCL6 CD5 CD6 DNTT FUT4
3 no phenotypic analysis MP:0003012 9.1 BCL6 CD5 KRT19 KRT5 PTPRC TP53

Drugs & Therapeutics for Epidural Neoplasm

Drugs for Epidural Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 151)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2180-92-9, 38396-39-3 2474
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 437-38-7 3345
3
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-27-2 5288826
4
Ropivacaine Approved Phase 4,Phase 3 84057-95-4 71273 175805
5
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
6
Ketorolac Approved Phase 4,Phase 2,Phase 1 74103-06-3, 66635-83-4 3826
7
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
8
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
9
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
10
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
11
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
12
Sevoflurane Approved, Vet_approved Phase 4,Phase 3 28523-86-6 5206
13
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
14
Sufentanil Approved, Investigational Phase 4,Phase 3,Phase 2 56030-54-7 41693
15
Levobupivacaine Approved Phase 4,Phase 2 27262-47-1 92253
16
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 1 137-58-6 3676
17
Clonidine Approved Phase 4,Phase 2,Phase 3 4205-90-7 2803
18
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
19 tannic acid Approved, Nutraceutical Phase 4
20 Adjuvants, Anesthesia Phase 4,Phase 3,Phase 2
21 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Analgesics, Opioid Phase 4,Phase 3,Phase 2,Phase 1
23 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Anesthetics, General Phase 4,Phase 3,Phase 2
25 Anesthetics, Intravenous Phase 4,Phase 3,Phase 2
26 Anesthetics, Local Phase 4,Phase 3,Phase 2,Phase 1
27 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Narcotics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
29 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
31 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Ketorolac Tromethamine Phase 4,Phase 2,Phase 1
33 Hypnotics and Sedatives Phase 4,Phase 3,Phase 2
34 Anti-Anxiety Agents Phase 4
35 Anticonvulsants Phase 4
36 calcium channel blockers Phase 4
37 Calcium, Dietary Phase 4
38 Psychotropic Drugs Phase 4
39 Tranquilizing Agents Phase 4
40 Epinephryl borate Phase 4,Phase 3,Phase 2,Phase 1
41 Racepinephrine Phase 4,Phase 3,Phase 2,Phase 1
42 Defensins Phase 4
43 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 1,Phase 2,Early Phase 1
44 Antirheumatic Agents Phase 4,Phase 1,Phase 2,Early Phase 1
45 Cyclooxygenase Inhibitors Phase 4
46 Liver Extracts Phase 4,Phase 3
47 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1
48 Adrenergic Agonists Phase 4,Phase 2,Phase 3,Phase 1
49 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Phase 3
50 Adrenergic alpha-Agonists Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 122)
id Name Status NCT ID Phase
1 Influence of Gum Chewing on Postoperative Bowel Activity After Complete Staging Surgery for Gynecological Malignancies Unknown status NCT01835119 Phase 4
2 Cardiac Arrhythmias in Patients Undergoing Kidney Cancer Surgery Depending on the Anaesthesia Method Completed NCT02988219 Phase 4
3 Comparison of the Effects of Continuous Epidural Analgesia and Continuous Intravenous Analgesia on Postoperative Bowel Movement in Patients Undergoing Laparoscopic Gastrectomy Completed NCT02458573 Phase 4
4 Comparison of the Analgesic Effect Between Intrathecal Morphine and IV-fentanyl Patient Controlled Analgesia (ITM-IVPCA) and Epidural PCA (PCEA) in Patients Undergoing Gastrectomy -Randomized Allocation Study- Completed NCT01234272 Phase 4
5 The Effect of Combined General/Epidural Anesthesia Versus General Anesthesia on Diaphragmatic Function Completed NCT01547416 Phase 4
6 Oxidative Stress Markers in Open and Laparoscopic Colectomy for Cancer Completed NCT00928928 Phase 4
7 Inflammatory Response in Laparoscopic and Open Colectomy Completed NCT00942461 Phase 4
8 Surgical Versus Nonoperative Treatment of Metastatic Epidural Spinal Cord Compression Completed NCT00634426 Phase 4
9 Antinociceptive Modalities on Ischemia Reperfusion Injury Completed NCT01932918 Phase 4
10 Effects of Dexmedetomidine Used in Continuous Thoracic Paravertebral Blocks Completed NCT02619513 Phase 4
11 Effects of Different Types of Perioperative Analgesia on Minimal Residual Disease Development After Colon Cancer Surgery Recruiting NCT02314871 Phase 4
12 Supplementary Epidural Analgesia in Video-Assisted Thoracic Surgery (VATS) - The SEAVATS Study Recruiting NCT02359175 Phase 4
13 Postoperative Pain Management After Minimally Invasive Esophagectomy Recruiting NCT02042313 Phase 4
14 Recovery and Analgesia After Surgery for Gynecological Cancer Active, not recruiting NCT02026687 Phase 4
15 The Effect of Dexmedetomidine as an Adjuvant for Lower Limb Nerve Blocks Not yet recruiting NCT03118076 Phase 4
16 Preemptive Analgesia Following Uterine Artery Embolization Terminated NCT01555073 Phase 4
17 RANDOMISED STUDY OF EPIDURAL VS MPCA MORPHINE VS TAPP IN LAPAROSCOPIC SIGMOIDECTOMY Unknown status NCT01825993 Phase 3
18 Epidural Hydromorphone Compared With Hydromorphone Infusion in Treating Patients With Prostate Cancer Undergoing Radical Prostatectomy Completed NCT00003115 Phase 3
19 Patient-Controlled Epidural Analgesia (PCEA) for Patients Who Have Had Major Open Gynecologic Surgery Completed NCT00136682 Phase 3
20 The Comparison Between Epidural and Intravenous Patient-controlled Analgesia for Laparoscopic Gastrectomy Completed NCT02444897 Phase 3
21 Effects of Anesthetic Technique on Immune and Inflammatory Systems Following Radical Prostatectomy Completed NCT01367418 Phase 3
22 Acupuncture for Post-Thoracotomy Pain Completed NCT00142532 Phase 3
23 Radiotherapy of Motor Deficits From Metastatic Epidural Spinal Cord Compression Completed NCT02189473 Phase 3
24 Restricted Intravenous Fluid Regime Effects on Immunological Indicators of Elderly Patients Operated for Abdominal Cancer Completed NCT01399814 Phase 3
25 Randomized Study of Spinal Anesthesia Compared With Traditional Epidural Anesthesia Concerning Peroperative and Postoperative Pain After Open Nephrectomy in Patients With Renal Cell Carcinoma Completed NCT02030717 Phase 2, Phase 3
26 Epidural Versus Patient-controlled Analgesia for Reduction in Long-term Mortality Following Colorectal Cancer Surgery Recruiting NCT01318161 Phase 3
27 Epidural Anesthesia Within an Enhanced Recovery Pathway in Reducing Pain in Patients Undergoing Gynecologic Surgery Recruiting NCT02423876 Phase 3
28 Patient Controlled Epidural Analgesia Versus Intravenous Patient Controlled Analgesia for Post-Operative Pain Control in Patients Undergoing Elective Liver Resection Recruiting NCT02523443 Phase 3
29 Regional Anesthesia and Breast Cancer Recurrence Recruiting NCT00418457 Phase 3
30 Dexmedetomidine,Ketamine and Their Combination to Bupivicaine on Thoracic Epidural Analgesia Recruiting NCT03063671 Phase 2, Phase 3
31 Zoledronic Acid Compared to Percutaneous Treatment in Osteoid Osteoma Recruiting NCT02739555 Phase 3
32 Intra-Peritoneal Local Anaesthesia After Cytoreductive Surgery Recruiting NCT02256228 Phase 3
33 Postoperative Thoracic Epidural Analgesia Versus Intravenous Patient-Controlled Analgesia For Liver and/or Pancreas Active, not recruiting NCT01438476 Phase 3
34 Study of Volume Reduction of Uterine Fibroids After Embolization or Microwave Treatment Not yet recruiting NCT02942537 Phase 2, Phase 3
35 Regional Anesthesia and Endometrial Cancer Recurrence Withdrawn NCT00531349 Phase 3
36 Thoracoscopic Lobectomy Using Nonintubated Anesthesia Versus Intubated General Anesthesia for Lung Cancer Patients Unknown status NCT01533233 Phase 1, Phase 2
37 Spine Stereotactic Body Radiation Therapy for Metastatic Epidural Spinal Cord Compression Unknown status NCT01826058 Phase 2
38 Peri-Operative Management of Patients Undergoing Laparoscopic Colorectal Surgery Unknown status NCT00747292 Phase 1, Phase 2
39 Randomized Study Comparing the Use of Epidural Analgesia to Intravenous Narcotics for Laparoscopic Colorectal Resection. Unknown status NCT02086123 Phase 2
40 Patient-Controlled Thoracic Paravertebral Block After Video-Assisted Thoracoscopic Surgery Unknown status NCT02237664 Phase 1, Phase 2
41 Study of REN-1654 in Patients With Sciatica Pain Unknown status NCT00107055 Phase 2
42 A Randomized Study of the Efficacy of Low Venous Pressure General Anesthesia Versus Combined Spinal-Epidural Anesthesia in Decreasing Blood Loss During Prostate Surgery Completed NCT00200187 Phase 2
43 Xenon Combined With Intraoperative Thoracic Epidural Analgesia Completed NCT01696630 Phase 2
44 Efficacy of Epidural Etanercept in the Treatment of Sciatica Completed NCT00364572 Phase 1, Phase 2
45 Epidural Analgesia Vs Rectus Sheath Block: Postoperative Analgesia and Proinflammatory Cytokines Completed NCT03074097 Phase 2
46 Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine Completed NCT01155440 Phase 2
47 Comparison of Thoracoscopic Talc Pleurodesis by Thoracic Epidural or General Anesthesia Completed NCT01469728 Phase 2
48 Safety and Efficacy of Intrathecal Morphine in Children Completed NCT03120403 Phase 2
49 Early Recovery After Surgery (ERAS) Versus Conventional Protocol After Laparoscopic Gastrectomy Completed NCT01938313 Phase 2
50 Comparison of Intratechal Levobupivacaine and Adding With Sufetanil and Fentanyl in Ceserean Section Completed NCT02430090 Phase 2

Search NIH Clinical Center for Epidural Neoplasm

Cochrane evidence based reviews: epidural neoplasms

Genetic Tests for Epidural Neoplasm

Anatomical Context for Epidural Neoplasm

MalaCards organs/tissues related to Epidural Neoplasm:

39
Spinal Cord, Bone

Publications for Epidural Neoplasm

Articles related to Epidural Neoplasm:

id Title Authors Year
1
Plain film clues to the diagnosis of spinal epidural neoplasm and infection. ( 8492898 )
1993
2
Evaluation of back pain caused by epidural neoplasm. ( 24573025 )
1993
3
Identification of epidural neoplasm. Radiography and bone scintigraphy in the symptomatic and asymptomatic spine. ( 2804911 )
1989
4
Circulatory disturbance of the spinal cord with epidural neoplasm in rats. ( 3926963 )
1985
5
Disturbance of the circulation in the spinal cord with epidural neoplasm. ( 4069060 )
1985
6
Experimental spinal cord compression by epidural neoplasm. ( 558545 )
1977

Variations for Epidural Neoplasm

Expression for Epidural Neoplasm

Search GEO for disease gene expression data for Epidural Neoplasm.

Pathways for Epidural Neoplasm

Pathways related to Epidural Neoplasm according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.29 CD6 CD99 PTPRC
2 10.65 BCL6 CD5 PTPRC TNFRSF8

GO Terms for Epidural Neoplasm

Cellular components related to Epidural Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 replication fork GO:0005657 8.62 BCL6 TP53

Biological processes related to Epidural Neoplasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of histone deacetylation GO:0031065 8.62 BCL6 TP53

Sources for Epidural Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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