MCID: EPD019
MIFTS: 32

Epidural Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Epidural Neoplasm

MalaCards integrated aliases for Epidural Neoplasm:

Name: Epidural Neoplasm 12 14
Epidural Neoplasms 41 69
Extradural Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3618
MeSH 41 D015174
NCIt 46 C3019
UMLS 69 C0014536

Summaries for Epidural Neoplasm

MalaCards based summary : Epidural Neoplasm, also known as epidural neoplasms, is related to spinal cancer and heart lymphoma. An important gene associated with Epidural Neoplasm is PTCHD3 (Patched Domain Containing 3), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and B Cell Development Pathways. The drugs Melphalan and Menthol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and bone, and related phenotypes are Increased proliferation and hematopoietic system

Related Diseases for Epidural Neoplasm

Diseases related to Epidural Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 spinal cancer 11.0
2 heart lymphoma 10.5 BCL6 PTPRC
3 breast lymphoma 10.5 BCL6 CD5
4 vulvar sarcoma 10.5 PTPRC SMARCB1
5 intravascular large b-cell lymphoma 10.4 BCL6 CD5
6 nodular lymphocyte predominant hodgkin lymphoma 10.4 BCL6 PTPRC
7 testicular lymphoma 10.4 BCL6 PTPRC
8 composite lymphoma 10.4 BCL6 CD5
9 malignant spiradenoma 10.4 KRT5 TP53
10 keratinizing squamous cell carcinoma 10.4 KRT5 TP53
11 cerebral ventricle cancer 10.4 SMARCB1 TP53
12 cerebrum cancer 10.4 SMARCB1 TP53
13 supratentorial cancer 10.4 SMARCB1 TP53
14 thymic epithelial tumor 10.4 CD5 CD99
15 plasmablastic lymphoma 10.3 BCL6 PTPRC
16 b cell prolymphocytic leukemia 10.3 CD5 TP53
17 breast adenomyoepithelioma 10.3 CD99 KRT5
18 breast myoepithelial neoplasm 10.3 CD99 KRT5
19 cloacogenic carcinoma 10.3 CD27 KRT5 PTPRC
20 pleomorphic xanthoastrocytoma 10.3 SMARCB1 TP53
21 cll/sll 10.3 CD5 TP53
22 t-cell/histiocyte rich large b cell lymphoma 10.3 BCL6 TNFRSF8
23 follicular lymphoma 10.3 BCL6 CD27 CD5
24 necrotizing sialometaplasia 10.2 CD5 KRT5 TP53
25 gastric lymphoma 10.2 BCL6 TP53
26 sarcomatoid squamous cell skin carcinoma 10.2 KRT5 PTPRC TP53
27 marek disease 10.2 TNFRSF8 TP53
28 conventional fibrosarcoma 10.2 PTPRC TNFRSF8
29 predominantly cortical thymoma 10.2 KRT19 PTPRC
30 mature b-cell neoplasm 10.2 BCL6 PTPRC TP53
31 adult lymphoma 10.2 CD5 TNFRSF8
32 kidney rhabdoid cancer 10.2 CD99 PTPRC SMARCB1
33 malignant biphasic mesothelioma 10.2 FUT4 KRT5
34 mantle cell lymphoma 10.2 BCL6 CD5 TP53
35 reticulum cell sarcoma 10.1 PTPRC TNFRSF8
36 odontoma 10.1 KRT19 KRT5
37 connective tissue cancer 10.1 CD99 SMARCB1 TP53
38 sternum cancer 10.1 FUT4 TNFRSF8
39 nervous system cancer 10.1 CD99 SMARCB1 TP53
40 bladder carcinoma in situ 10.1 KRT19 TP53
41 malignant epithelial mesothelioma 10.1 CD5 FUT4 KRT5
42 lung lymphoma 10.1 BCL6 CD5 TNFRSF8
43 reticulosarcoma 10.1 BCL6 PTPRC TNFRSF8
44 lymphoma, hodgkin, classic 10.1 BCL6 PTPRC TNFRSF8
45 glomangiosarcoma 10.0 DNTT TP53
46 extraskeletal ewing sarcoma 10.0 CD99 PTPRC
47 cervical clear cell adenocarcinoma 10.0 KRT19 KRT5
48 malignant leydig cell tumor 10.0 KRT19 TNFRSF8
49 cell type cancer 10.0 KRT19 KRT5 TP53
50 mediastinal malignant lymphoma 9.9 BCL6 FUT4 TNFRSF8

Graphical network of the top 20 diseases related to Epidural Neoplasm:



Diseases related to Epidural Neoplasm

Symptoms & Phenotypes for Epidural Neoplasm

GenomeRNAi Phenotypes related to Epidural Neoplasm according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 SMARCB1 TP53

MGI Mouse Phenotypes related to Epidural Neoplasm:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 ANKRD11 BCL6 CD27 CD5 CD6 DNTT
2 immune system MP:0005387 9.36 CD5 CD6 DNTT FUT4 PTPRC SMARCB1

Drugs & Therapeutics for Epidural Neoplasm

Drugs for Epidural Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 1 148-82-3 460612 4053
2
Menthol Approved Phase 1 2216-51-5 16666
3 Alkylating Agents Phase 1
4 Anesthetics Phase 1
5 Immunosuppressive Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intra-arterial Chemotherapy for Spinal Metastases Recruiting NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
2 Adaptive Staged Stereotactic Body Radiation Therapy in Treating Patients With Spinal Metastases That Cannot Be Removed by Surgery Unknown status NCT02527304
3 Optimal Timing of Postoperative Magnetic Resonance Imaging (MRI) in Patients With Extradural Spinal Recruiting NCT02790294

Search NIH Clinical Center for Epidural Neoplasm

Cochrane evidence based reviews: epidural neoplasms

Genetic Tests for Epidural Neoplasm

Anatomical Context for Epidural Neoplasm

MalaCards organs/tissues related to Epidural Neoplasm:

38
Spinal Cord, Bone

Publications for Epidural Neoplasm

Articles related to Epidural Neoplasm:

# Title Authors Year
1
Plain film clues to the diagnosis of spinal epidural neoplasm and infection. ( 8492898 )
1993
2
Evaluation of back pain caused by epidural neoplasm. ( 24573025 )
1993
3
Identification of epidural neoplasm. Radiography and bone scintigraphy in the symptomatic and asymptomatic spine. ( 2804911 )
1989
4
Circulatory disturbance of the spinal cord with epidural neoplasm in rats. ( 3926963 )
1985
5
Disturbance of the circulation in the spinal cord with epidural neoplasm. ( 4069060 )
1985
6
Experimental spinal cord compression by epidural neoplasm. ( 558545 )
1977

Variations for Epidural Neoplasm

Expression for Epidural Neoplasm

Search GEO for disease gene expression data for Epidural Neoplasm.

Pathways for Epidural Neoplasm

Pathways related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 CD6 CD99 PTPRC
2 10.75 BCL6 CD27 CD5 PTPRC TNFRSF8

GO Terms for Epidural Neoplasm

Cellular components related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replication fork GO:0005657 8.62 BCL6 TP53

Biological processes related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of histone deacetylation GO:0031065 8.62 BCL6 TP53

Molecular functions related to Epidural Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.62 CD27 TNFRSF8

Sources for Epidural Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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