MCID: EPT011
MIFTS: 44

Epithelioid Leiomyosarcoma malady

Cancer diseases category

Summaries for Epithelioid Leiomyosarcoma

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34MalaCards
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MalaCards: Epithelioid Leiomyosarcoma, also known as leiomyosarcoma, epithelioid, is related to leiomyosarcoma and sarcoma. An important gene associated with Epithelioid Leiomyosarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Cytoskeletal Signaling. The compounds naphthol as-d chloroacetate and silver have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and skin, and related mouse phenotypes are respiratory system and homeostasis/metabolism.

Aliases & Classifications for Epithelioid Leiomyosarcoma

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9Disease Ontology, 46Novoseek, 63UMLS, 36MeSH, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

epithelioid leiomyosarcoma 9
leiomyosarcoma, epithelioid 63
leiomyosarcoma epithelioid 46


External Ids:

Disease Ontology9 DOID:5264
MeSH36 D007890
SNOMED-CT59 42392001
NCIt41 C3700

Related Diseases for Epithelioid Leiomyosarcoma

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18GeneCards, 19GeneDecks
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Diseases related to Epithelioid Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma31.5DES, VIM, ACTC1, ENO2
2sarcoma30.0ENO2, ACTC1, VIM, PTPRC, DES
3uterine corpus epithelioid leiomyosarcoma10.4
4paraganglioma10.3
5chondroma10.3
6pemphigus10.1
7neuronitis10.1
8tuberous sclerosis10.1
9lymphangioleiomyomatosis10.1
10peutz-jeghers syndrome10.1
11cervicitis10.1
12pericardial effusion10.1
13respiratory failure10.1
14paraneoplastic pemphigus10.1
15infantile myofibromatosis10.1DES
16fasciitis10.1ACTC1
17chondroblastoma10.1PTHLH
18adenomatoid tumor10.1VIM
19epulis10.1ENO2
20cerebral primitive neuroectodermal tumor10.1ENO2
21neurilemmoma10.1ENO2
22subependymal giant cell astrocytoma10.1ENO2
23peripheral primitive neuroectodermal tumor10.1ENO2
24ganglioglioma10.1ENO2
25desmoid tumor10.1ACTC1, DES
26cutaneous fibrous histiocytoma10.1ACTC1, DES
27adenosarcoma10.1ACTC1, DES
28mesenchymal chondrosarcoma10.1DES, VIM
29sex cord-gonadal stromal tumor10.1DES, VIM
30myoepithelioma10.1ACTC1, VIM
31chordoma10.1DES, VIM
32malignant peripheral nerve sheath tumor10.0ACTC1, VIM
33alveolar rhabdomyosarcoma10.0DES, ENO2
34neurofibroma10.0VIM, ACTC1
35liposarcoma10.0DES, VIM
36synovial sarcoma10.0VIM, DES
37tubular adenocarcinoma10.0ACTC1, ENO2
38hemorrhage, intracerebral10.0SERPINA3, ENO2
39creutzfeldt-jakob disease10.0SERPINA3, ENO2
40malignant mesothelioma10.0VIM, DES
41inflammatory myofibroblastic tumor10.0PTPRC, DES
42dilated cardiomyopathy10.0ACTC1, DES
43teratoma10.0ACTC1, ENO2
44pseudosarcomatous fibromatosis10.0DES, VIM, ACTC1
45spindle cell carcinoma10.0DES, VIM, ACTC1
46spindle cell sarcoma10.0DES, VIM, ACTC1
47large cell carcinoma10.0PTHLH, ENO2
48dermatofibrosarcoma protuberans10.0DES, VIM, ACTC1
49endometrial stromal sarcoma10.0ACTC1, VIM, DES
50hemangiopericytoma10.0DES, VIM, ACTC1

Graphical network of the top 20 diseases related to Epithelioid Leiomyosarcoma:



Diseases related to epithelioid leiomyosarcoma

Symptoms for Epithelioid Leiomyosarcoma

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Drugs & Therapeutics for Epithelioid Leiomyosarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Epithelioid Leiomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Epithelioid Leiomyosarcoma

Search NIH Clinical Center for Epithelioid Leiomyosarcoma

Search CenterWatch for Epithelioid Leiomyosarcoma

Genetic Tests for Epithelioid Leiomyosarcoma

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Anatomical Context for Epithelioid Leiomyosarcoma

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34MalaCards
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MalaCards organs/tissues related to Epithelioid Leiomyosarcoma:

34
Uterus, Cervix, Skin, Liver, Ovary, Bone, Smooth muscle, Colon, Breast, Small intestine, Lymph node

Animal Models for Epithelioid Leiomyosarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Epithelioid Leiomyosarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9ENO2, VIM, PTPRC, PTHLH
2MP:00053767.7ACTC1, VIM, PTPRC, PTHLH, DES
3MP:00053847.3PTHLH, PTPRC, VIM, ACTC1, ENO2

Publications for Epithelioid Leiomyosarcoma

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53PubMed
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Articles related to Epithelioid Leiomyosarcoma:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Epithelioid leiomyosarcoma of uterus. (22602833)
2012
2
A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. (21410837)
2011
3
Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide. (21440979)
2011
4
A rare case of primitive epithelioid leiomyosarcoma of the conjunctiva. (21574810)
2011
5
Epithelioid leiomyosarcoma of the uterus containing sex cord-like elements. (19952934)
2010
6
Cardiac epithelioid leiomyosarcoma and the role of cardiac imaging in the differentiation of intracardiac masses. (20552587)
2010
7
Epithelioid leiomyosarcoma with rhabdoid features. (17943409)
2007
8
Epithelioid leiomyosarcoma in the visceral peritoneum of an American badger (Taxidea taxus). (15690961)
2005
9
Primary extradural epithelioid leiomyosarcoma of the cervical spine: case report and literature review. (16094142)
2005
10
Epithelioid leiomyosarcoma of the ovary. (15863185)
2005
11
Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa. (15043315)
2004
12
Primary paratesticular epithelioid leiomyosarcoma. (12740499)
2003
13
Epithelioid leiomyosarcoma of the gastrocolic ligament. (12658888)
2003
14
A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature. (12683897)
2003
15
Cytological diagnosis of metastatic epithelioid leiomyosarcoma to lymph node--a diagnostic dilemma. (14632734)
2003
16
Epithelioid leiomyosarcoma of the external deep soft tissue. (12683863)
2003
17
Rhabdoid epithelioid leiomyosarcoma of the uterine corpus: a case report and literature review. (12232582)
2002
18
Epithelioid leiomyosarcoma of the uterine cervix. (11531304)
2001
19
Epithelioid leiomyosarcoma in a non-immunocompromised infant: additional differential diagnosis of pediatric "round cell tumors". (11048812)
2000
20
Epithelioid leiomyosarcoma of the stomach: report of a case. (10714261)
2000
21
Paraneoplastic pemphigus caused by an epithelioid leiomyosarcoma and associated with fatal respiratory failure. (10899680)
2000
22
Epithelioid leiomyosarcoma with osteoclast-like giant cells in the rectum. (10705403)
2000
23
Uterine malignant leiomyoblastoma (epithelioid leiomyosarcoma) during pregnancy. (10053121)
1999
24
Cytological findings of abdominal malignant leiomyoblastoma (epithelioid leiomyosarcoma) in ascitic fluid; a case report. (10588354)
1999
25
Epithelioid lymphangioleiomyomatosis-like tumour of the uterus in a patient without tuberous sclerosis: a lesion mimicking epithelioid leiomyosarcoma. (9726062)
1998
26
Neuron-specific enolase-producing epithelioid leiomyosarcoma with gross vascular invasion and intracardiac involvement. (9870863)
1998
27
Epithelioid leiomyosarcoma of the uterine cervix. (9512340)
1998
28
Epithelioid leiomyosarcoma of the larynx. (9702545)
1998
29
Fine needle aspiration cytology of gastric epithelioid leiomyosarcoma metastasized to the liver. A case report. (9390146)
1997
30
Uterine epithelioid leiomyosarcoma in a pig-tailed macaque. (9029402)
1996
31
Primary multiple epithelioid leiomyosarcoma of the liver. (8975973)
1996
32
Epithelioid leiomyosarcoma of retroperitoneum with granular cell change. (7959652)
1994
33
Differential alpha-smooth muscle actin expression in a gastric epithelioid leiomyosarcoma in a 14 year old girl. (8203266)
1994
34
Epithelioid leiomyosarcoma of the skin and subcutaneous tissue. Clinicopathologic, immunohistochemical, and ultrastructural study of five cases. (8116792)
1994
35
A case report of epithelioid leiomyosarcoma of transverse mesocolon: diagnosis and treatment. (8253608)
1993
36
Epithelioid leiomyosarcoma of the breast: report of a case. (8104588)
1993
37
Subungual epithelioid leiomyosarcoma. (1585213)
1992
38
Myxoid variant of epithelioid leiomyosarcoma of the uterus. (1812693)
1991
39
Combined therapy in the treatment of gastric epithelioid leiomyosarcoma. (2314523)
1990
40
Indolent gastric epithelioid leiomyosarcoma in Carney's Triad. (2261725)
1990
41
Gastric epithelioid leiomyosarcoma. (3631047)
1987
42
Epithelioid leiomyosarcoma of the stomach. A case study of the intermediate filaments. (3300387)
1987
43
Epithelioid leiomyosarcoma of the uterus. (3943041)
1986
44
Giant nuclear bodies in epithelioid leiomyosarcoma. (3612018)
1986
45
Epithelioid leiomyosarcoma originating in a hamartomatous polyp from a patient with Peutz-Jeghers syndrome. (3972226)
1985
46
The triad of gastric epithelioid leiomyosarcoma, pulmonary chondroma, and functioning extra-adrenal paraganglioma: a five-year review. (6843355)
1983
47
Bizarre leiomyoblastoma (epithelioid leiomyosarcoma) of the uterus--a case with a malignant clinical course. (6864015)
1983
48
Epithelioid leiomyosarcoma (malignant leiomyoblastoma) of the colon. (6872794)
1983
49
The triad of gastric epithelioid leiomyosarcoma, functioning extra-adrenal paraganglioma, and pulmonary chondroma. (367573)
1979
50
Recurrent and metastasizing gastric leiomyoblastoma (epithelioid leiomyosarcoma) associated with multiple pulmonary chondro-hamartomas: long survival of a patient treated with repeated operations. (626934)
1978

Variations for Epithelioid Leiomyosarcoma

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Expression for genes affiliated with Epithelioid Leiomyosarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Epithelioid Leiomyosarcoma

Search GEO for disease gene expression data for Epithelioid Leiomyosarcoma.

Pathways for genes affiliated with Epithelioid Leiomyosarcoma

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51PathCards, 39NCBI BioSystems Database, 5Cell Signaling Technology, 56Reactome
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Pathways related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases39
Aurora C signaling39
9.3VIM, DES
28.9ACTC1, VIM, DES
3
Show member pathways
8.9ACTC1, VIM, DES

Compounds for genes affiliated with Epithelioid Leiomyosarcoma

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46Novoseek, 25HMDB, 12DrugBank, 3BitterDB, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1naphthol as-d chloroacetate469.7PTPRC, SERPINA3
2silver469.5DES, SERPINA3, ENO2
3monochloroacetic acid469.3VIM, PTPRC
4orcein469.3ACTC1, VIM, DES
5reticulin469.3DES, ACTC1, VIM
6mucicarmine469.3VIM, DES, ACTC1
7procollagen469.2ACTC1, DES, VIM
8biotin46 25 1211.1ACTC1, VIM, DES
9sialic acid469.1ENO2, PTPRC, SERPINA3
10progestin469.1PTHLH, VIM, DES
11azathioprine46 3 52 1212.0VIM, DES, PTHLH
12ibmx46 62 3011.0PTPRC, ENO2, PTHLH
13dbc-amp468.9PTHLH, VIM, ENO2
142-methoxyethanol468.9ACTC1, VIM
15dihydrotestosterone46 30 25 1211.9DES, VIM, PTHLH
16ionomycin468.9PTHLH, PTPRC, SERPINA3
17heparan sulfate46 259.9DES, PTHLH, VIM
18s 100468.8ENO2, ACTC1, VIM, DES
19steroid468.8ACTC1, SERPINA3, PTHLH, DES
20b 723468.7ACTC1, PTPRC, DES, VIM
21estradiol46 25 1210.7VIM, SERPINA3, PTHLH, DES
22bromodeoxyuridine468.6DES, ENO2, VIM, PTHLH
23toluidine468.6VIM, ENO2, DES, PTPRC
24methionine468.6VIM, DES, PTPRC, SERPINA3
25oxygen46 259.6SERPINA3, PTHLH, DES, ACTC1, ENO2
26glucose468.6ENO2, ACTC1, SERPINA3, PTHLH, DES
27lactate468.5PTHLH, DES, VIM, ENO2
28ganglioside468.5DES, VIM, ENO2, PTPRC
29hyaluronic acid46 259.5ENO2, VIM, PTPRC, DES
3012-o-tetradecanoylphorbol 13-acetate468.5PTHLH, DES, VIM, PTPRC
31fmlp468.5PTPRC, VIM, SERPINA3
32adenylate468.5ENO2, VIM, DES, PTHLH
33iron46 259.3DES, VIM, ACTC1, SERPINA3, ENO2
34vegf468.2DES, ACTC1, ENO2, VIM, PTHLH
35acetylcholine46 52 30 25 1212.2PTHLH, SERPINA3, ENO2, VIM, DES
36hematoxylin468.2VIM, ACTC1, ENO2, DES, PTPRC
37formaldehyde46 259.2ACTC1, ENO2, PTPRC, DES, VIM
38tyrosine468.0DES, PTHLH, PTPRC, ACTC1, ENO2
39calcium46 52 25 1210.9ENO2, ACTC1, SERPINA3, PTPRC, PTHLH, DES
40serine467.8PTHLH, DES, SERPINA3, VIM, PTPRC
41lipid467.8PTHLH, PTPRC, SERPINA3, ENO2, VIM
42creatinine467.8DES, PTHLH, ENO2, ACTC1, SERPINA3, VIM
43retinoic acid46 258.8DES, PTHLH, ACTC1, SERPINA3, ENO2, VIM
44glycogen46 258.6ACTC1, VIM, ENO2, DES, PTHLH, PTPRC
45testosterone46 62 25 1210.6ACTC1, PTPRC, DES, PTHLH, VIM, ENO2
46heparin46 30 25 1210.6VIM, PTPRC, PTHLH, DES, ENO2, SERPINA3
47dexamethasone46 52 30 1210.5SERPINA3, PTPRC, PTHLH, VIM, ACTC1, ENO2
48paraffin467.2DES, PTPRC, SERPINA3, VIM, ACTC1, ENO2
49progesterone46 30 62 25 1211.2ACTC1, VIM, SERPINA3, PTHLH, DES, ENO2
50estrogen467.2DES, ACTC1, ENO2, PTHLH, PTPRC, SERPINA3

GO Terms for genes affiliated with Epithelioid Leiomyosarcoma

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17Gene Ontology
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Cellular components related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.3VIM, DES
2extracellular vesicular exosomeGO:0700627.3ENO2, ACTC1, VIM, SERPINA3, PTPRC

Biological processes related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300498.9ACTC1, VIM, DES

Molecular functions related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3VIM, DES

Products for genes affiliated with Epithelioid Leiomyosarcoma

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Sources for Epithelioid Leiomyosarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet