MCID: EPT011
MIFTS: 44

Epithelioid Leiomyosarcoma malady

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Summaries for Epithelioid Leiomyosarcoma

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MalaCards based summary: Epithelioid Leiomyosarcoma, also known as leiomyosarcoma, epithelioid, is related to leiomyosarcoma and paraganglioma. An important gene associated with Epithelioid Leiomyosarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Cytoskeletal Signaling. The compounds naphthol as-d chloroacetate and silver have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and liver, and related mouse phenotypes are respiratory system and homeostasis/metabolism.

Aliases & Classifications for Epithelioid Leiomyosarcoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt
See all sources

Epithelioid Leiomyosarcoma, Aliases & Descriptions:

Name: Epithelioid Leiomyosarcoma 8
Leiomyosarcoma, Epithelioid 62
 
Leiomyosarcoma Epithelioid 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:5264
MeSH34 D007890
SNOMED-CT57 42392001
NCIt39 C3700

Related Diseases for Epithelioid Leiomyosarcoma

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Diseases related to Epithelioid Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma31.3DES, VIM, ACTC1, ENO2
2paraganglioma30.6DES, VIM, ACTC1
3sarcoma29.4ENO2, ACTC1, VIM, PTPRC, DES
4infantile myofibromatosis10.5DES
5fasciitis10.5ACTC1
6chondroblastoma10.4PTHLH
7adenomatoid tumor10.4VIM
8epulis10.4ENO2
9cerebral primitive neuroectodermal tumor10.4ENO2
10neurilemmoma10.4ENO2
11uterine corpus epithelioid leiomyosarcoma10.4
12subependymal giant cell astrocytoma10.4ENO2
13peripheral primitive neuroectodermal tumor10.4ENO2
14ganglioglioma10.3ENO2
15desmoid tumor10.3ACTC1, DES
16cutaneous fibrous histiocytoma10.3ACTC1, DES
17adenosarcoma10.3ACTC1, DES
18chondroma10.3
19mesenchymal chondrosarcoma10.3DES, VIM
20sex cord-gonadal stromal tumor10.2DES, VIM
21myoepithelioma10.2ACTC1, VIM
22chordoma10.2DES, VIM
23malignant peripheral nerve sheath tumor10.2ACTC1, VIM
24alveolar rhabdomyosarcoma10.2DES, ENO2
25neurofibroma10.2VIM, ACTC1
26liposarcoma10.2DES, VIM
27synovial sarcoma10.2VIM, DES
28tubular adenocarcinoma10.2ACTC1, ENO2
29hemorrhage, intracerebral10.2SERPINA3, ENO2
30creutzfeldt-jakob disease10.1SERPINA3, ENO2
31malignant mesothelioma10.1VIM, DES
32inflammatory myofibroblastic tumor10.1PTPRC, DES
33tuberous sclerosis10.1
34pemphigus10.1
35neuronitis10.1
36lymphangioleiomyomatosis10.1
37peutz-jeghers syndrome10.1
38cervicitis10.1
39pericardial effusion10.1
40respiratory failure10.1
41paraneoplastic pemphigus10.1
42dilated cardiomyopathy10.1ACTC1, DES
43teratoma10.1ACTC1, ENO2
44pseudosarcomatous fibromatosis10.1DES, VIM, ACTC1
45spindle cell carcinoma10.1DES, VIM, ACTC1
46spindle cell sarcoma10.1DES, VIM, ACTC1
47large cell carcinoma10.1PTHLH, ENO2
48dermatofibrosarcoma protuberans10.1DES, VIM, ACTC1
49endometrial stromal sarcoma10.1ACTC1, VIM, DES
50hemangiopericytoma10.1DES, VIM, ACTC1

Graphical network of the top 20 diseases related to Epithelioid Leiomyosarcoma:



Diseases related to epithelioid leiomyosarcoma

Symptoms for Epithelioid Leiomyosarcoma

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Drugs & Therapeutics for Epithelioid Leiomyosarcoma

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Drug clinical trials:

Search ClinicalTrials for Epithelioid Leiomyosarcoma

Search NIH Clinical Center for Epithelioid Leiomyosarcoma

Genetic Tests for Epithelioid Leiomyosarcoma

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Anatomical Context for Epithelioid Leiomyosarcoma

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MalaCards organs/tissues related to Epithelioid Leiomyosarcoma:

32
Uterus, Cervix, Liver, Skin, Bone, Lymph node, Smooth muscle, Small intestine, Colon, Breast, Ovary

Animal Models for Epithelioid Leiomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Epithelioid Leiomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9ENO2, VIM, PTPRC, PTHLH
2MP:00053767.7ACTC1, VIM, PTPRC, PTHLH, DES
3MP:00053847.3PTHLH, PTPRC, VIM, ACTC1, ENO2

Publications for Epithelioid Leiomyosarcoma

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Articles related to Epithelioid Leiomyosarcoma:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
Epithelioid leiomyosarcoma of uterus. (22602833)
2012
2
A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. (21410837)
2011
3
A rare case of primitive epithelioid leiomyosarcoma of the conjunctiva. (21574810)
2011
4
Epithelioid leiomyosarcoma of the uterus containing sex cord-like elements. (19952934)
2010
5
Cardiac epithelioid leiomyosarcoma and the role of cardiac imaging in the differentiation of intracardiac masses. (20552587)
2010
6
Epithelioid leiomyosarcoma with rhabdoid features. (17943409)
2007
7
Epithelioid leiomyosarcoma in the visceral peritoneum of an American badger (Taxidea taxus). (15690961)
2005
8
Primary extradural epithelioid leiomyosarcoma of the cervical spine: case report and literature review. (16094142)
2005
9
Epithelioid leiomyosarcoma of the ovary. (15863185)
2005
10
Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa. (15043315)
2004
11
Primary paratesticular epithelioid leiomyosarcoma. (12740499)
2003
12
Epithelioid leiomyosarcoma of the gastrocolic ligament. (12658888)
2003
13
A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature. (12683897)
2003
14
Cytological diagnosis of metastatic epithelioid leiomyosarcoma to lymph node--a diagnostic dilemma. (14632734)
2003
15
Epithelioid leiomyosarcoma of the external deep soft tissue. (12683863)
2003
16
Rhabdoid epithelioid leiomyosarcoma of the uterine corpus: a case report and literature review. (12232582)
2002
17
Epithelioid leiomyosarcoma of the uterine cervix. (11531304)
2001
18
Epithelioid leiomyosarcoma in a non-immunocompromised infant: additional differential diagnosis of pediatric "round cell tumors". (11048812)
2000
19
Epithelioid leiomyosarcoma of the stomach: report of a case. (10714261)
2000
20
Paraneoplastic pemphigus caused by an epithelioid leiomyosarcoma and associated with fatal respiratory failure. (10899680)
2000
21
Epithelioid leiomyosarcoma with osteoclast-like giant cells in the rectum. (10705403)
2000
22
Uterine malignant leiomyoblastoma (epithelioid leiomyosarcoma) during pregnancy. (10053121)
1999
23
Cytological findings of abdominal malignant leiomyoblastoma (epithelioid leiomyosarcoma) in ascitic fluid; a case report. (10588354)
1999
24
Epithelioid lymphangioleiomyomatosis-like tumour of the uterus in a patient without tuberous sclerosis: a lesion mimicking epithelioid leiomyosarcoma. (9726062)
1998
25
Neuron-specific enolase-producing epithelioid leiomyosarcoma with gross vascular invasion and intracardiac involvement. (9870863)
1998
26
Epithelioid leiomyosarcoma of the uterine cervix. (9512340)
1998
27
Epithelioid leiomyosarcoma of the larynx. (9702545)
1998
28
Epithelioid leiomyosarcoma of the skin. (9563281)
1998
29
Fine needle aspiration cytology of gastric epithelioid leiomyosarcoma metastasized to the liver. A case report. (9390146)
1997
30
Uterine epithelioid leiomyosarcoma in a pig-tailed macaque. (9029402)
1996
31
Primary multiple epithelioid leiomyosarcoma of the liver. (8975973)
1996
32
Epithelioid leiomyosarcoma of retroperitoneum with granular cell change. (7959652)
1994
33
Differential alpha-smooth muscle actin expression in a gastric epithelioid leiomyosarcoma in a 14 year old girl. (8203266)
1994
34
Epithelioid leiomyosarcoma of the skin and subcutaneous tissue. Clinicopathologic, immunohistochemical, and ultrastructural study of five cases. (8116792)
1994
35
A case report of epithelioid leiomyosarcoma of transverse mesocolon: diagnosis and treatment. (8253608)
1993
36
Epithelioid leiomyosarcoma of the breast: report of a case. (8104588)
1993
37
Epithelioid leiomyosarcoma of the oral cavity: report of two cases and review of the literature. (8336232)
1993
38
Subungual epithelioid leiomyosarcoma. (1585213)
1992
39
Myxoid variant of epithelioid leiomyosarcoma of the uterus. (1812693)
1991
40
Indolent gastric epithelioid leiomyosarcoma in Carney's Triad. (2261725)
1990
41
Gastric epithelioid leiomyosarcoma. (3631047)
1987
42
Epithelioid leiomyosarcoma of the stomach. A case study of the intermediate filaments. (3300387)
1987
43
Epithelioid leiomyosarcoma of the uterus. (3943041)
1986
44
Giant nuclear bodies in epithelioid leiomyosarcoma. (3612018)
1986
45
Epithelioid leiomyosarcoma originating in a hamartomatous polyp from a patient with Peutz-Jeghers syndrome. (3972226)
1985
46
The triad of gastric epithelioid leiomyosarcoma, pulmonary chondroma, and functioning extra-adrenal paraganglioma: a five-year review. (6843355)
1983
47
Bizarre leiomyoblastoma (epithelioid leiomyosarcoma) of the uterus--a case with a malignant clinical course. (6864015)
1983
48
Epithelioid leiomyosarcoma (malignant leiomyoblastoma) of the colon. (6872794)
1983
49
The triad of gastric epithelioid leiomyosarcoma, functioning extra-adrenal paraganglioma, and pulmonary chondroma. (367573)
1979
50
Recurrent and metastasizing gastric leiomyoblastoma (epithelioid leiomyosarcoma) associated with multiple pulmonary chondro-hamartomas: long survival of a patient treated with repeated operations. (626934)
1978

Variations for Epithelioid Leiomyosarcoma

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Expression for genes affiliated with Epithelioid Leiomyosarcoma

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Expression patterns in normal tissues for genes affiliated with Epithelioid Leiomyosarcoma

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Pathways for genes affiliated with Epithelioid Leiomyosarcoma

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Pathways related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.3VIM, DES
28.9ACTC1, VIM, DES
3
Show member pathways
8.9ACTC1, VIM, DES

Compounds for genes affiliated with Epithelioid Leiomyosarcoma

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Compounds related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1naphthol as-d chloroacetate449.7PTPRC, SERPINA3
2silver449.5DES, SERPINA3, ENO2
3monochloroacetic acid449.3VIM, PTPRC
4orcein449.3ACTC1, VIM, DES
5reticulin449.3DES, ACTC1, VIM
6mucicarmine449.3VIM, DES, ACTC1
7procollagen449.2ACTC1, DES, VIM
8biotin44 24 1111.1ACTC1, VIM, DES
9sialic acid449.1ENO2, PTPRC, SERPINA3
10progestin449.1PTHLH, VIM, DES
11azathioprine44 2 50 1112.0VIM, DES, PTHLH
12ibmx44 61 2811.0PTPRC, ENO2, PTHLH
13dbc-amp448.9PTHLH, VIM, ENO2
142-methoxyethanol448.9ACTC1, VIM
15dihydrotestosterone44 28 24 1111.9DES, VIM, PTHLH
16ionomycin448.9PTHLH, PTPRC, SERPINA3
17heparan sulfate44 249.9DES, PTHLH, VIM
18s 100448.8ENO2, ACTC1, VIM, DES
19steroid448.8ACTC1, SERPINA3, PTHLH, DES
20b 723448.7ACTC1, PTPRC, DES, VIM
21estradiol44 24 1110.7VIM, SERPINA3, PTHLH, DES
22bromodeoxyuridine448.6DES, ENO2, VIM, PTHLH
23toluidine448.6VIM, ENO2, DES, PTPRC
24methionine448.6VIM, DES, PTPRC, SERPINA3
25oxygen44 249.6SERPINA3, PTHLH, DES, ACTC1, ENO2
26glucose448.6ENO2, ACTC1, SERPINA3, PTHLH, DES
27lactate448.5PTHLH, DES, VIM, ENO2
28ganglioside448.5DES, VIM, ENO2, PTPRC
29hyaluronic acid44 249.5ENO2, VIM, PTPRC, DES
3012-o-tetradecanoylphorbol 13-acetate448.5PTHLH, DES, VIM, PTPRC
31fmlp448.5PTPRC, VIM, SERPINA3
32adenylate448.5ENO2, VIM, DES, PTHLH
33iron44 249.3DES, VIM, ACTC1, SERPINA3, ENO2
34vegf448.2DES, ACTC1, ENO2, VIM, PTHLH
35acetylcholine44 50 28 24 1112.2PTHLH, SERPINA3, ENO2, VIM, DES
36hematoxylin448.2VIM, ACTC1, ENO2, DES, PTPRC
37formaldehyde44 249.2ACTC1, ENO2, PTPRC, DES, VIM
38tyrosine448.0DES, PTHLH, PTPRC, ACTC1, ENO2
39calcium44 50 24 1110.9ENO2, ACTC1, SERPINA3, PTPRC, PTHLH, DES
40serine447.8PTHLH, DES, SERPINA3, VIM, PTPRC
41lipid447.8PTHLH, PTPRC, SERPINA3, ENO2, VIM
42creatinine447.8DES, PTHLH, ENO2, ACTC1, SERPINA3, VIM
43retinoic acid44 248.8DES, PTHLH, ACTC1, SERPINA3, ENO2, VIM
44glycogen44 248.6ACTC1, VIM, ENO2, DES, PTHLH, PTPRC
45testosterone44 61 24 1110.6ACTC1, PTPRC, DES, PTHLH, VIM, ENO2
46heparin44 28 24 1110.6VIM, PTPRC, PTHLH, DES, ENO2, SERPINA3
47dexamethasone44 50 28 1110.5SERPINA3, PTPRC, PTHLH, VIM, ACTC1, ENO2
48paraffin447.2DES, PTPRC, SERPINA3, VIM, ACTC1, ENO2
49progesterone44 28 61 24 1111.2ACTC1, VIM, SERPINA3, PTHLH, DES, ENO2
50estrogen447.2DES, ACTC1, ENO2, PTHLH, PTPRC, SERPINA3

GO Terms for genes affiliated with Epithelioid Leiomyosarcoma

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Cellular components related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.3VIM, DES
2extracellular vesicular exosomeGO:0700627.3ENO2, ACTC1, VIM, SERPINA3, PTPRC

Biological processes related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300498.9ACTC1, VIM, DES

Molecular functions related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3VIM, DES

Products for genes affiliated with Epithelioid Leiomyosarcoma

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Sources for Epithelioid Leiomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet