MCID: EPT011
MIFTS: 39

Epithelioid Leiomyosarcoma malady

Summaries for Epithelioid Leiomyosarcoma

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32MalaCards
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MalaCards: Epithelioid Leiomyosarcoma, also known as leiomyosarcoma, epithelioid, is related to leiomyosarcoma and paraganglioma. An important gene associated with Epithelioid Leiomyosarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Cytoskeletal Signaling. The compounds naphthol as-d chloroacetate and prostaglandin have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and liver, and related mouse phenotype respiratory system.

Aliases & Classifications for Epithelioid Leiomyosarcoma

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

epithelioid leiomyosarcoma 8
leiomyosarcoma, epithelioid 60
leiomyosarcoma epithelioid 44


External Ids:

Disease Ontology8 DOID:5264
MeSH34 D007890
SNOMED-CT56 42392001
NCIt39 C3700

Related Diseases for Epithelioid Leiomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Epithelioid Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma31.4ENO2, ACTC1, DES, VIM
2paraganglioma30.3ENO2
3lymphangioleiomyomatosis30.1DES
4sarcoma30.0ENO2, PTPRC, ACTC1, DES, VIM
5gastric leiomyosarcoma10.6
6uterus leiomyosarcoma10.5
7uterine corpus epithelioid leiomyosarcoma10.4
8liver leiomyosarcoma10.2
9chondroma10.2
10tuberous sclerosis10.1
11bone leiomyosarcoma10.1
12pemphigus10.1
13neuronitis10.1
14small intestine leiomyosarcoma10.1
15larynx leiomyosarcoma10.1
16breast leiomyosarcoma10.1
17granular cell leiomyosarcoma10.1
18colon leiomyosarcoma10.1
19myxoid leiomyosarcoma10.1
20ovary leiomyosarcoma10.1
21rectum leiomyosarcoma10.1
22peutz-jeghers syndrome10.1
23cervicitis10.1
24pericardial effusion10.1
25respiratory failure10.1
26infantile myofibromatosis10.0DES
27hemangioma10.0ACTC1
28lipoma10.0DES
29fasciitis10.0ACTC1
30myopathy10.0DES
31endometriosis10.0ACTC1
32meningioma10.0VIM
33epulis10.0ENO2
34rhabdoid cancer10.0ENO2
35neurilemmoma10.0ENO2
36cerebral primitive neuroectodermal tumor10.0ENO2
37peripheral primitive neuroectodermal tumor10.0ENO2
38seminoma10.0ENO2
39hemangioblastoma10.0ENO2
40malignant histiocytosis10.0SERPINA3
41merkel cell carcinoma10.0ENO2
42epidermolysis bullosa simplex10.0DES
43arthritis10.0SERPINA3
44thymoma10.0PTPRC
45neuroblastoma10.0ENO2
46subependymal giant cell astrocytoma10.0ENO2
47adenomatoid tumor10.0VIM
48perineurioma10.0VIM
49stomach cancer10.0SERPINA3
50leydig cell tumor10.0PTHLH

Graphical network of the top 20 diseases related to Epithelioid Leiomyosarcoma:



Diseases related to epithelioid leiomyosarcoma

Clinical Features for Epithelioid Leiomyosarcoma

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Drugs & Therapeutics for Epithelioid Leiomyosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Epithelioid Leiomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Epithelioid Leiomyosarcoma

Search NIH Clinical Center for Epithelioid Leiomyosarcoma

Search CenterWatch for Epithelioid Leiomyosarcoma

Genetic Tests for Epithelioid Leiomyosarcoma

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Anatomical Context for Epithelioid Leiomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Epithelioid Leiomyosarcoma:

32
Uterus, Cervix, Liver, Bone, Skin, Lymph node, Ovary, Breast, Smooth muscle, Small intestine, Colon

Animal Models for Epithelioid Leiomyosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Epithelioid Leiomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.0ENO2, PTPRC, PTHLH, VIM

Publications for Epithelioid Leiomyosarcoma

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50PubMed
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Articles related to Epithelioid Leiomyosarcoma:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Epithelioid Leiomyosarcoma Arising in the Subcutis-A New Case Report of a Rare Variant. (23739249)
2013
2
Cardiac epithelioid leiomyosarcoma as both intracardiac and pericardial mass with massive pericardial effusion: a rare presentation. (23916929)
2013
3
Epithelioid leiomyosarcoma of uterus. (22602833)
2012
4
A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. (21410837)
2011
5
Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide. (21440979)
2011
6
A rare case of primitive epithelioid leiomyosarcoma of the conjunctiva. (21574810)
2011
7
Cardiac epithelioid leiomyosarcoma and the role of cardiac imaging in the differentiation of intracardiac masses. (20552587)
2010
8
Epithelioid leiomyosarcoma of the uterus: computed tomography findings. (20882890)
2010
9
Epithelioid leiomyosarcoma with rhabdoid features. (17943409)
2007
10
Pleomorphic epithelioid/clear cell malignant tumor of the uterus exhibiting both myoid and melanocytic differentiation--leiomyosarcoma or PEComa? A case report and a review of the literature]. (17821838)
2007
11
Epithelioid leiomyosarcoma in the visceral peritoneum of an American badger (Taxidea taxus). (15690961)
2005
12
Primary extradural epithelioid leiomyosarcoma of the cervical spine: case report and literature review. (16094142)
2005
13
Epithelioid leiomyosarcoma of the ovary. (15863185)
2005
14
Epithelioid leiomyosarcoma: case report and review of the literature. (16409271)
2005
15
Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature. (15890394)
2005
16
Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa. (15043315)
2004
17
Primary paratesticular epithelioid leiomyosarcoma. (12740499)
2003
18
Epithelioid leiomyosarcoma of the gastrocolic ligament. (12658888)
2003
19
Cytological diagnosis of metastatic epithelioid leiomyosarcoma to lymph node--a diagnostic dilemma. (14632734)
2003
20
Epithelioid leiomyosarcoma of the external deep soft tissue. (12683863)
2003
21
Epithelioid leiomyosarcoma of the external deep soft tissue. (11900575)
2002
22
Epithelioid leiomyosarcoma of the uterine cervix. (11531304)
2001
23
Epithelioid leiomyosarcoma in a non-immunocompromised infant: additional differential diagnosis of pediatric "round cell tumors". (11048812)
2000
24
Paraneoplastic pemphigus caused by an epithelioid leiomyosarcoma and associated with fatal respiratory failure. (10899680)
2000
25
Epithelioid leiomyosarcoma with osteoclast-like giant cells in the rectum. (10705403)
2000
26
Uterine malignant leiomyoblastoma (epithelioid leiomyosarcoma) during pregnancy. (10053121)
1999
27
Primary epithelioid leiomyosarcoma of bone. Case report and literature review. (10335949)
1999
28
Neuron-specific enolase-producing epithelioid leiomyosarcoma with gross vascular invasion and intracardiac involvement. (9870863)
1998
29
Epithelioid leiomyosarcoma of the uterine cervix. (9512340)
1998
30
Epithelioid leiomyosarcoma of the larynx. (9702545)
1998
31
Epithelioid leiomyosarcoma of the skin. (9563281)
1998
32
Primary multiple epithelioid leiomyosarcoma of the liver. (8975973)
1996
33
Gastric stump carcinoma occurring in a patient with Carney's triad 38 years after partial gastrectomy for epithelioid leiomyosarcoma. (7864713)
1995
34
Differential alpha-smooth muscle actin expression in a gastric epithelioid leiomyosarcoma in a 14 year old girl. (8203266)
1994
35
A case report of epithelioid leiomyosarcoma of transverse mesocolon: diagnosis and treatment. (8253608)
1993
36
Epithelioid leiomyosarcoma of the breast: report of a case. (8104588)
1993
37
Epithelioid leiomyosarcoma of the oral cavity: report of two cases and review of the literature. (8336232)
1993
38
Myxoid variant of epithelioid leiomyosarcoma of the uterus. (1812693)
1991
39
A case of leiomyoblastoma (epithelioid leiomyosarcoma) of the greater omentum. (1832406)
1991
40
Combined therapy in the treatment of gastric epithelioid leiomyosarcoma. (2314523)
1990
41
Indolent gastric epithelioid leiomyosarcoma in Carney's Triad. (2261725)
1990
42
Epithelioid leiomyosarcoma of the left atrium: immunohistochemical and ultrastructural findings. (2483752)
1989
43
Epithelioid leiomyosarcoma of the stomach. A case study of the intermediate filaments. (3300387)
1987
44
Epithelioid leiomyosarcoma of the small intestine with oncocytic change. (3675157)
1987
45
Epithelioid leiomyosarcoma of the uterus. (3943041)
1986
46
Giant nuclear bodies in epithelioid leiomyosarcoma. (3612018)
1986
47
Epithelioid leiomyosarcoma originating in a hamartomatous polyp from a patient with Peutz-Jeghers syndrome. (3972226)
1985
48
The triad of gastric epithelioid leiomyosarcoma, pulmonary chondroma, and functioning extra-adrenal paraganglioma: a five-year review. (6843355)
1983
49
Bizarre leiomyoblastoma (epithelioid leiomyosarcoma) of the uterus--a case with a malignant clinical course. (6864015)
1983
50
Epithelioid leiomyosarcoma (malignant leiomyoblastoma) of the colon. (6872794)
1983

Genetic Variations for Epithelioid Leiomyosarcoma

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Expression for genes affiliated with Epithelioid Leiomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Epithelioid Leiomyosarcoma

Search GEO for disease gene expression data for Epithelioid Leiomyosarcoma.

Pathways for genes affiliated with Epithelioid Leiomyosarcoma

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37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome
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Pathways related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3DES, VIM
28.9ACTC1, DES, VIM
3
Hide members
8.9ACTC1, DES, VIM

Compounds for genes affiliated with Epithelioid Leiomyosarcoma

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1naphthol as-d chloroacetate449.8PTPRC, SERPINA3
2prostaglandin449.7VIM
3heparin44 28 11 2412.6SERPINA3, DES, PTPRC
4monochloroacetic acid449.5VIM, PTPRC
5silver449.5SERPINA3, DES, ENO2
62-methoxyethanol449.4VIM, ACTC1
7creatinine449.4ACTC1, PTHLH, SERPINA3
8orcein449.3ACTC1, VIM, DES
9acetylcholine44 49 28 11 2413.3ENO2, SERPINA3, PTHLH
10reticulin449.3ACTC1, DES, VIM
11mucicarmine449.3VIM, ACTC1, DES
12sialic acid449.2ENO2, SERPINA3, PTPRC
13biotin44 11 2411.2VIM, ACTC1, DES
14tartrate449.1PTHLH, VIM
15ibmx44 28 5911.0ENO2, PTPRC, PTHLH
16ionomycin449.0PTHLH, SERPINA3, PTPRC
17progestin449.0DES, VIM, PTHLH
18azathioprine44 49 2 1112.0PTHLH, DES, VIM
19dihydrotestosterone44 28 11 2411.9DES, VIM, PTHLH
20dbc-amp448.9PTHLH, VIM, ENO2
21heparan sulfate44 249.8DES, PTHLH, VIM
22s 100448.8VIM, DES, ACTC1, ENO2
23b 723448.8DES, PTPRC, VIM, ACTC1
24fmlp448.7VIM, PTPRC, SERPINA3
25methionine448.7VIM, DES, PTPRC, SERPINA3
26toluidine448.7VIM, DES, PTPRC, ENO2
27ganglioside448.7VIM, ENO2, DES, PTPRC
28hyaluronic acid44 249.6VIM, DES, PTPRC, ENO2
29dmso448.6PTPRC, VIM, ENO2
30estradiol44 11 2410.6SERPINA3, PTHLH, VIM, DES
31bromodeoxyuridine448.5ENO2, VIM, PTHLH, DES
3212-o-tetradecanoylphorbol 13-acetate448.5VIM, PTHLH, DES, PTPRC
33valine448.5SERPINA3, VIM, PTHLH
34oxygen44 249.5SERPINA3, PTHLH, ENO2, DES, ACTC1
35glucose448.4DES, ACTC1, PTHLH, ENO2, SERPINA3
36lactate448.4ENO2, VIM, DES, PTHLH
37adenylate448.4DES, ENO2, PTHLH, VIM
38steroid448.3PTHLH, SERPINA3, DES, ACTC1
39iron44 249.3ENO2, SERPINA3, ACTC1, DES, VIM
40hematoxylin448.3VIM, DES, ACTC1, PTPRC, ENO2
41formaldehyde44 249.3DES, VIM, ENO2, PTPRC, ACTC1
42vegf448.1ACTC1, PTHLH, ENO2, VIM, DES
43calcium44 49 11 2410.9DES, ENO2, SERPINA3, PTPRC, PTHLH, ACTC1
44lipid447.8PTHLH, VIM, PTPRC, SERPINA3, ENO2
45retinoic acid44 248.7SERPINA3, DES, ENO2, VIM, PTHLH, ACTC1
46glycogen44 248.6VIM, ENO2, PTPRC, PTHLH, DES, ACTC1
47testosterone44 59 11 2410.6PTHLH, PTPRC, ENO2, DES, VIM, ACTC1
48dexamethasone44 49 28 1110.5VIM, SERPINA3, ENO2, PTPRC, PTHLH, ACTC1
49paraffin447.2SERPINA3, ENO2, VIM, PTHLH, ACTC1, DES
50progesterone44 59 28 11 2411.2ENO2, SERPINA3, PTPRC, PTHLH, ACTC1, DES

GO Terms for genes affiliated with Epithelioid Leiomyosarcoma

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16Gene Ontology
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Biological processes related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300498.9ACTC1, DES, VIM

Products for genes affiliated with Epithelioid Leiomyosarcoma

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Sources for Epithelioid Leiomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet