MCID: EPT011
MIFTS: 44

Epithelioid Leiomyosarcoma malady

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Summaries for Epithelioid Leiomyosarcoma

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MalaCards: Epithelioid Leiomyosarcoma, also known as leiomyosarcoma, epithelioid, is related to leiomyosarcoma and sarcoma. An important gene associated with Epithelioid Leiomyosarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Cytoskeletal Signaling. The compounds naphthol as-d chloroacetate and silver have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and skin, and related mouse phenotypes are respiratory system and homeostasis/metabolism.

Aliases & Classifications for Epithelioid Leiomyosarcoma

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8Disease Ontology, 45Novoseek, 62UMLS, 35MeSH, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

epithelioid leiomyosarcoma 8
leiomyosarcoma, epithelioid 62
leiomyosarcoma epithelioid 45


External Ids:

Disease Ontology8 DOID:5264
MeSH35 D007890
SNOMED-CT58 42392001
NCIt40 C3700

Related Diseases for Epithelioid Leiomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Epithelioid Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma31.5DES, VIM, ACTC1, ENO2
2sarcoma30.0ENO2, ACTC1, VIM, PTPRC, DES
3uterine corpus epithelioid leiomyosarcoma10.4
4paraganglioma10.3
5chondroma10.3
6pemphigus10.1
7neuronitis10.1
8tuberous sclerosis10.1
9lymphangioleiomyomatosis10.1
10peutz-jeghers syndrome10.1
11cervicitis10.1
12pericardial effusion10.1
13respiratory failure10.1
14paraneoplastic pemphigus10.1
15infantile myofibromatosis10.1DES
16fasciitis10.1ACTC1
17chondroblastoma10.1PTHLH
18adenomatoid tumor10.1VIM
19epulis10.1ENO2
20cerebral primitive neuroectodermal tumor10.1ENO2
21neurilemmoma10.1ENO2
22subependymal giant cell astrocytoma10.1ENO2
23peripheral primitive neuroectodermal tumor10.1ENO2
24ganglioglioma10.1ENO2
25desmoid tumor10.1ACTC1, DES
26cutaneous fibrous histiocytoma10.1ACTC1, DES
27adenosarcoma10.1ACTC1, DES
28mesenchymal chondrosarcoma10.1DES, VIM
29sex cord-gonadal stromal tumor10.1DES, VIM
30myoepithelioma10.1ACTC1, VIM
31chordoma10.1DES, VIM
32malignant peripheral nerve sheath tumor10.0ACTC1, VIM
33alveolar rhabdomyosarcoma10.0DES, ENO2
34neurofibroma10.0VIM, ACTC1
35liposarcoma10.0DES, VIM
36synovial sarcoma10.0VIM, DES
37tubular adenocarcinoma10.0ACTC1, ENO2
38hemorrhage, intracerebral10.0SERPINA3, ENO2
39creutzfeldt-jakob disease10.0SERPINA3, ENO2
40malignant mesothelioma10.0VIM, DES
41inflammatory myofibroblastic tumor10.0PTPRC, DES
42dilated cardiomyopathy10.0ACTC1, DES
43teratoma10.0ACTC1, ENO2
44pseudosarcomatous fibromatosis10.0DES, VIM, ACTC1
45spindle cell carcinoma10.0DES, VIM, ACTC1
46spindle cell sarcoma10.0DES, VIM, ACTC1
47large cell carcinoma10.0PTHLH, ENO2
48dermatofibrosarcoma protuberans10.0DES, VIM, ACTC1
49endometrial stromal sarcoma10.0ACTC1, VIM, DES
50hemangiopericytoma10.0DES, VIM, ACTC1

Graphical network of the top 20 diseases related to Epithelioid Leiomyosarcoma:



Diseases related to epithelioid leiomyosarcoma

Symptoms for Epithelioid Leiomyosarcoma

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Drugs & Therapeutics for Epithelioid Leiomyosarcoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Epithelioid Leiomyosarcoma

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Genetic Tests for Epithelioid Leiomyosarcoma

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Anatomical Context for Epithelioid Leiomyosarcoma

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33MalaCards
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MalaCards organs/tissues related to Epithelioid Leiomyosarcoma:

33
Uterus, Cervix, Skin, Liver, Ovary, Bone, Smooth muscle, Colon, Breast, Small intestine, Lymph node

Animal Models for Epithelioid Leiomyosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Epithelioid Leiomyosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053887.9ENO2, VIM, PTPRC, PTHLH
2MP:00053767.7ACTC1, VIM, PTPRC, PTHLH, DES
3MP:00053847.3PTHLH, PTPRC, VIM, ACTC1, ENO2

Publications for Epithelioid Leiomyosarcoma

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52PubMed
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Articles related to Epithelioid Leiomyosarcoma:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Epithelioid leiomyosarcoma of uterus. (22602833)
2012
2
A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. (21410837)
2011
3
Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide. (21440979)
2011
4
A rare case of primitive epithelioid leiomyosarcoma of the conjunctiva. (21574810)
2011
5
Epithelioid leiomyosarcoma of the uterus containing sex cord-like elements. (19952934)
2010
6
Cardiac epithelioid leiomyosarcoma and the role of cardiac imaging in the differentiation of intracardiac masses. (20552587)
2010
7
Epithelioid leiomyosarcoma with rhabdoid features. (17943409)
2007
8
Epithelioid leiomyosarcoma in the visceral peritoneum of an American badger (Taxidea taxus). (15690961)
2005
9
Primary extradural epithelioid leiomyosarcoma of the cervical spine: case report and literature review. (16094142)
2005
10
Epithelioid leiomyosarcoma of the ovary. (15863185)
2005
11
Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa. (15043315)
2004
12
Primary paratesticular epithelioid leiomyosarcoma. (12740499)
2003
13
Epithelioid leiomyosarcoma of the gastrocolic ligament. (12658888)
2003
14
A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature. (12683897)
2003
15
Cytological diagnosis of metastatic epithelioid leiomyosarcoma to lymph node--a diagnostic dilemma. (14632734)
2003
16
Epithelioid leiomyosarcoma of the external deep soft tissue. (12683863)
2003
17
Rhabdoid epithelioid leiomyosarcoma of the uterine corpus: a case report and literature review. (12232582)
2002
18
Epithelioid leiomyosarcoma of the uterine cervix. (11531304)
2001
19
Epithelioid leiomyosarcoma in a non-immunocompromised infant: additional differential diagnosis of pediatric "round cell tumors". (11048812)
2000
20
Epithelioid leiomyosarcoma of the stomach: report of a case. (10714261)
2000
21
Paraneoplastic pemphigus caused by an epithelioid leiomyosarcoma and associated with fatal respiratory failure. (10899680)
2000
22
Epithelioid leiomyosarcoma with osteoclast-like giant cells in the rectum. (10705403)
2000
23
Uterine malignant leiomyoblastoma (epithelioid leiomyosarcoma) during pregnancy. (10053121)
1999
24
Cytological findings of abdominal malignant leiomyoblastoma (epithelioid leiomyosarcoma) in ascitic fluid; a case report. (10588354)
1999
25
Epithelioid lymphangioleiomyomatosis-like tumour of the uterus in a patient without tuberous sclerosis: a lesion mimicking epithelioid leiomyosarcoma. (9726062)
1998
26
Neuron-specific enolase-producing epithelioid leiomyosarcoma with gross vascular invasion and intracardiac involvement. (9870863)
1998
27
Epithelioid leiomyosarcoma of the uterine cervix. (9512340)
1998
28
Epithelioid leiomyosarcoma of the larynx. (9702545)
1998
29
Fine needle aspiration cytology of gastric epithelioid leiomyosarcoma metastasized to the liver. A case report. (9390146)
1997
30
Uterine epithelioid leiomyosarcoma in a pig-tailed macaque. (9029402)
1996
31
Primary multiple epithelioid leiomyosarcoma of the liver. (8975973)
1996
32
Epithelioid leiomyosarcoma of retroperitoneum with granular cell change. (7959652)
1994
33
Differential alpha-smooth muscle actin expression in a gastric epithelioid leiomyosarcoma in a 14 year old girl. (8203266)
1994
34
Epithelioid leiomyosarcoma of the skin and subcutaneous tissue. Clinicopathologic, immunohistochemical, and ultrastructural study of five cases. (8116792)
1994
35
A case report of epithelioid leiomyosarcoma of transverse mesocolon: diagnosis and treatment. (8253608)
1993
36
Epithelioid leiomyosarcoma of the breast: report of a case. (8104588)
1993
37
Subungual epithelioid leiomyosarcoma. (1585213)
1992
38
Myxoid variant of epithelioid leiomyosarcoma of the uterus. (1812693)
1991
39
Combined therapy in the treatment of gastric epithelioid leiomyosarcoma. (2314523)
1990
40
Indolent gastric epithelioid leiomyosarcoma in Carney's Triad. (2261725)
1990
41
Gastric epithelioid leiomyosarcoma. (3631047)
1987
42
Epithelioid leiomyosarcoma of the stomach. A case study of the intermediate filaments. (3300387)
1987
43
Epithelioid leiomyosarcoma of the uterus. (3943041)
1986
44
Giant nuclear bodies in epithelioid leiomyosarcoma. (3612018)
1986
45
Epithelioid leiomyosarcoma originating in a hamartomatous polyp from a patient with Peutz-Jeghers syndrome. (3972226)
1985
46
The triad of gastric epithelioid leiomyosarcoma, pulmonary chondroma, and functioning extra-adrenal paraganglioma: a five-year review. (6843355)
1983
47
Bizarre leiomyoblastoma (epithelioid leiomyosarcoma) of the uterus--a case with a malignant clinical course. (6864015)
1983
48
Epithelioid leiomyosarcoma (malignant leiomyoblastoma) of the colon. (6872794)
1983
49
The triad of gastric epithelioid leiomyosarcoma, functioning extra-adrenal paraganglioma, and pulmonary chondroma. (367573)
1979
50
Recurrent and metastasizing gastric leiomyoblastoma (epithelioid leiomyosarcoma) associated with multiple pulmonary chondro-hamartomas: long survival of a patient treated with repeated operations. (626934)
1978

Variations for Epithelioid Leiomyosarcoma

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Expression for genes affiliated with Epithelioid Leiomyosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Epithelioid Leiomyosarcoma

Search GEO for disease gene expression data for Epithelioid Leiomyosarcoma.

Pathways for genes affiliated with Epithelioid Leiomyosarcoma

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50PathCards, 38NCBI BioSystems Database, 5Cell Signaling Technology, 55Reactome
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Pathways related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases38
Aurora C signaling38
9.3VIM, DES
28.9ACTC1, VIM, DES
3
Show member pathways
8.9ACTC1, VIM, DES

Compounds for genes affiliated with Epithelioid Leiomyosarcoma

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45Novoseek, 24HMDB, 11DrugBank, 3BitterDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1naphthol as-d chloroacetate459.7PTPRC, SERPINA3
2silver459.5DES, SERPINA3, ENO2
3monochloroacetic acid459.3VIM, PTPRC
4orcein459.3ACTC1, VIM, DES
5reticulin459.3DES, ACTC1, VIM
6mucicarmine459.3VIM, DES, ACTC1
7procollagen459.2ACTC1, DES, VIM
8biotin45 24 1111.1ACTC1, VIM, DES
9sialic acid459.1ENO2, PTPRC, SERPINA3
10progestin459.1PTHLH, VIM, DES
11azathioprine45 3 51 1112.0VIM, DES, PTHLH
12ibmx45 61 2911.0PTPRC, ENO2, PTHLH
13dbc-amp458.9PTHLH, VIM, ENO2
142-methoxyethanol458.9ACTC1, VIM
15dihydrotestosterone45 29 24 1111.9DES, VIM, PTHLH
16ionomycin458.9PTHLH, PTPRC, SERPINA3
17heparan sulfate45 249.9DES, PTHLH, VIM
18s 100458.8ENO2, ACTC1, VIM, DES
19steroid458.8ACTC1, SERPINA3, PTHLH, DES
20b 723458.7ACTC1, PTPRC, DES, VIM
21estradiol45 24 1110.7VIM, SERPINA3, PTHLH, DES
22bromodeoxyuridine458.6DES, ENO2, VIM, PTHLH
23toluidine458.6VIM, ENO2, DES, PTPRC
24methionine458.6VIM, DES, PTPRC, SERPINA3
25oxygen45 249.6SERPINA3, PTHLH, DES, ACTC1, ENO2
26glucose458.6ENO2, ACTC1, SERPINA3, PTHLH, DES
27lactate458.5PTHLH, DES, VIM, ENO2
28ganglioside458.5DES, VIM, ENO2, PTPRC
29hyaluronic acid45 249.5ENO2, VIM, PTPRC, DES
3012-o-tetradecanoylphorbol 13-acetate458.5PTHLH, DES, VIM, PTPRC
31fmlp458.5PTPRC, VIM, SERPINA3
32adenylate458.5ENO2, VIM, DES, PTHLH
33iron45 249.3DES, VIM, ACTC1, SERPINA3, ENO2
34vegf458.2DES, ACTC1, ENO2, VIM, PTHLH
35acetylcholine45 51 29 24 1112.2PTHLH, SERPINA3, ENO2, VIM, DES
36hematoxylin458.2VIM, ACTC1, ENO2, DES, PTPRC
37formaldehyde45 249.2ACTC1, ENO2, PTPRC, DES, VIM
38tyrosine458.0DES, PTHLH, PTPRC, ACTC1, ENO2
39calcium45 51 24 1110.9ENO2, ACTC1, SERPINA3, PTPRC, PTHLH, DES
40serine457.8PTHLH, DES, SERPINA3, VIM, PTPRC
41lipid457.8PTHLH, PTPRC, SERPINA3, ENO2, VIM
42creatinine457.8DES, PTHLH, ENO2, ACTC1, SERPINA3, VIM
43retinoic acid45 248.8DES, PTHLH, ACTC1, SERPINA3, ENO2, VIM
44glycogen45 248.6ACTC1, VIM, ENO2, DES, PTHLH, PTPRC
45testosterone45 61 24 1110.6ACTC1, PTPRC, DES, PTHLH, VIM, ENO2
46heparin45 29 24 1110.6VIM, PTPRC, PTHLH, DES, ENO2, SERPINA3
47dexamethasone45 51 29 1110.5SERPINA3, PTPRC, PTHLH, VIM, ACTC1, ENO2
48paraffin457.2DES, PTPRC, SERPINA3, VIM, ACTC1, ENO2
49progesterone45 29 61 24 1111.2ACTC1, VIM, SERPINA3, PTHLH, DES, ENO2
50estrogen457.2DES, ACTC1, ENO2, PTHLH, PTPRC, SERPINA3

GO Terms for genes affiliated with Epithelioid Leiomyosarcoma

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16Gene Ontology
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Cellular components related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.3VIM, DES
2extracellular vesicular exosomeGO:0700627.3ENO2, ACTC1, VIM, SERPINA3, PTPRC

Biological processes related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300498.9ACTC1, VIM, DES

Molecular functions related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3VIM, DES

Products for genes affiliated with Epithelioid Leiomyosarcoma

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Sources for Epithelioid Leiomyosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet