MCID: EPT011
MIFTS: 39

Epithelioid Leiomyosarcoma malady

Summaries for Epithelioid Leiomyosarcoma

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32MalaCards
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MalaCards: Epithelioid Leiomyosarcoma, also known as leiomyosarcoma, epithelioid, is related to leiomyosarcoma and paraganglioma. An important gene associated with Epithelioid Leiomyosarcoma is DES (desmin), and among its related pathways are Aurora B signaling and Cytoskeletal Signaling. The compounds naphthol as-d chloroacetate and prostaglandin have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and liver, and related mouse phenotype respiratory system.

Aliases & Classifications for Epithelioid Leiomyosarcoma

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

epithelioid leiomyosarcoma 8
leiomyosarcoma, epithelioid 60
leiomyosarcoma epithelioid 44


External Ids:

Disease Ontology8 DOID:5264
MeSH34 D007890
SNOMED-CT56 42392001
NCIt39 C3700

Related Diseases for Epithelioid Leiomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Epithelioid Leiomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma31.4ENO2, ACTC1, DES, VIM
2paraganglioma30.3ENO2
3lymphangioleiomyomatosis30.1DES
4sarcoma30.0ENO2, PTPRC, ACTC1, DES, VIM
5gastric leiomyosarcoma10.6
6uterus leiomyosarcoma10.5
7uterine corpus epithelioid leiomyosarcoma10.4
8liver leiomyosarcoma10.2
9chondroma10.2
10tuberous sclerosis10.1
11bone leiomyosarcoma10.1
12pemphigus10.1
13neuronitis10.1
14small intestine leiomyosarcoma10.1
15larynx leiomyosarcoma10.1
16breast leiomyosarcoma10.1
17granular cell leiomyosarcoma10.1
18colon leiomyosarcoma10.1
19myxoid leiomyosarcoma10.1
20ovary leiomyosarcoma10.1
21rectum leiomyosarcoma10.1
22peutz-jeghers syndrome10.1
23cervicitis10.1
24pericardial effusion10.1
25respiratory failure10.1
26infantile myofibromatosis10.0DES
27hemangioma10.0ACTC1
28lipoma10.0DES
29fasciitis10.0ACTC1
30myopathy10.0DES
31endometriosis10.0ACTC1
32meningioma10.0VIM
33epulis10.0ENO2
34rhabdoid cancer10.0ENO2
35neurilemmoma10.0ENO2
36cerebral primitive neuroectodermal tumor10.0ENO2
37peripheral primitive neuroectodermal tumor10.0ENO2
38seminoma10.0ENO2
39hemangioblastoma10.0ENO2
40malignant histiocytosis10.0SERPINA3
41merkel cell carcinoma10.0ENO2
42epidermolysis bullosa simplex10.0DES
43arthritis10.0SERPINA3
44thymoma10.0PTPRC
45neuroblastoma10.0ENO2
46subependymal giant cell astrocytoma10.0ENO2
47adenomatoid tumor10.0VIM
48perineurioma10.0VIM
49stomach cancer10.0SERPINA3
50leydig cell tumor10.0PTHLH

Graphical network of the top 20 diseases related to Epithelioid Leiomyosarcoma:



Diseases related to epithelioid leiomyosarcoma

Clinical Features for Epithelioid Leiomyosarcoma

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Drugs & Therapeutics for Epithelioid Leiomyosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Epithelioid Leiomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Epithelioid Leiomyosarcoma

Search NIH Clinical Center for Epithelioid Leiomyosarcoma

Search CenterWatch for Epithelioid Leiomyosarcoma

Genetic Tests for Epithelioid Leiomyosarcoma

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Anatomical Context for Epithelioid Leiomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Epithelioid Leiomyosarcoma:

32
Uterus, Cervix, Liver, Bone, Skin, Lymph node, Ovary, Breast, Smooth muscle, Small intestine, Colon

Animal Models for Epithelioid Leiomyosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Epithelioid Leiomyosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.0ENO2, PTPRC, PTHLH, VIM

Publications for Epithelioid Leiomyosarcoma

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50PubMed
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Articles related to Epithelioid Leiomyosarcoma:

(show top 50)    (show all 72)
idTitleAuthorsYear
1
Effects of TRAIL and taurolidine on apoptosis and proliferation in human rhabdomyosarcoma, leiomyosarcoma and epithelioid cell sarcoma. (23338823)
2013
2
Epithelioid Leiomyosarcoma Arising in the Subcutis-A New Case Report of a Rare Variant. (23739249)
2013
3
A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. (21410837)
2011
4
Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide. (21440979)
2011
5
Epithelioid leiomyosarcoma of the uterus containing sex cord-like elements. (19952934)
2010
6
Cardiac epithelioid leiomyosarcoma and the role of cardiac imaging in the differentiation of intracardiac masses. (20552587)
2010
7
Epithelioid leiomyosarcoma of the uterus: computed tomography findings. (20882890)
2010
8
Coexistence of two rare sarcomas: primary leiomyosarcoma of bone and epithelioid hemangioendothelioma of the liver. (18382610)
2008
9
Epithelioid leiomyosarcoma with rhabdoid features. (17943409)
2007
10
Epithelioid leiomyosarcoma: case report and review of the literature. (16409271)
2005
11
Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature. (15890394)
2005
12
A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature. (12683897)
2003
13
Epithelioid leiomyosarcoma of the external deep soft tissue. (12683863)
2003
14
Rhabdoid epithelioid leiomyosarcoma of the uterine corpus: a case report and literature review. (12232582)
2002
15
Using thalidomide in a patient with epithelioid leiomyosarcoma and Osler-Weber-Rendu disease. (11831608)
2002
16
Epithelioid leiomyosarcoma of the external deep soft tissue. (11900575)
2002
17
Epithelioid leiomyosarcoma of the uterine cervix. (11531304)
2001
18
Epithelioid leiomyosarcoma of the uterus with oncocytic change. (11569929)
2001
19
Epithelioid leiomyosarcoma in a non-immunocompromised infant: additional differential diagnosis of pediatric "round cell tumors". (11048812)
2000
20
Epithelioid leiomyosarcoma of the stomach: report of a case. (10714261)
2000
21
Paraneoplastic pemphigus caused by an epithelioid leiomyosarcoma and associated with fatal respiratory failure. (10899680)
2000
22
Epithelioid leiomyosarcoma with osteoclast-like giant cells in the rectum. (10705403)
2000
23
Cytological findings of abdominal malignant leiomyoblastoma (epithelioid leiomyosarcoma) in ascitic fluid; a case report. (10588354)
1999
24
Epithelioid lymphangioleiomyomatosis-like tumour of the uterus in a patient without tuberous sclerosis: a lesion mimicking epithelioid leiomyosarcoma. (9726062)
1998
25
Neuron-specific enolase-producing epithelioid leiomyosarcoma with gross vascular invasion and intracardiac involvement. (9870863)
1998
26
Epithelioid leiomyosarcoma of the uterine cervix. (9512340)
1998
27
Epithelioid leiomyosarcoma of the skin. (9563281)
1998
28
Fine needle aspiration cytology of gastric epithelioid leiomyosarcoma metastasized to the liver. A case report. (9390146)
1997
29
Uterine epithelioid leiomyosarcoma in a pig-tailed macaque. (9029402)
1996
30
Primary multiple epithelioid leiomyosarcoma of the liver. (8975973)
1996
31
Malignant plexiform tumor of the uterus: an unusual variant of epithelioid leiomyosarcoma. (8910640)
1996
32
Epithelioid leiomyosarcoma of retroperitoneum with granular cell change. (7959652)
1994
33
Epithelioid leiomyosarcoma of the skin and subcutaneous tissue. Clinicopathologic, immunohistochemical, and ultrastructural study of five cases. (8116792)
1994
34
A case report of epithelioid leiomyosarcoma of transverse mesocolon: diagnosis and treatment. (8253608)
1993
35
Epithelioid leiomyosarcoma of the breast: report of a case. (8104588)
1993
36
Epithelioid leiomyosarcoma of the oral cavity: report of two cases and review of the literature. (8336232)
1993
37
Subungual epithelioid leiomyosarcoma. (1585213)
1992
38
Combined therapy in the treatment of gastric epithelioid leiomyosarcoma. (2314523)
1990
39
Epithelioid leiomyosarcoma of gastrointestinal tract. (2125911)
1990
40
Epithelioid leiomyosarcoma of the left atrium: immunohistochemical and ultrastructural findings. (2483752)
1989
41
Gastric epithelioid leiomyosarcoma. (3631047)
1987
42
Epithelioid leiomyosarcoma of the stomach. A case study of the intermediate filaments. (3300387)
1987
43
Gastric epithelioid leiomyosarcoma: a curable gastric neoplasm. (3799586)
1987
44
Epithelioid leiomyosarcoma of the uterus. (3943041)
1986
45
Giant nuclear bodies in epithelioid leiomyosarcoma. (3612018)
1986
46
Malignant leiomyoblastoma (epithelioid leiomyosarcoma) of the duodenum. (6722679)
1984
47
The triad of gastric epithelioid leiomyosarcoma, pulmonary chondroma, and functioning extra-adrenal paraganglioma: a five-year review. (6843355)
1983
48
Bizarre leiomyoblastoma (epithelioid leiomyosarcoma) of the uterus--a case with a malignant clinical course. (6864015)
1983
49
The triad of gastric epithelioid leiomyosarcoma, functioning extra-adrenal paraganglioma, and pulmonary chondroma. (367573)
1979
50
Recurrent and metastasizing gastric leiomyoblastoma (epithelioid leiomyosarcoma) associated with multiple pulmonary chondro-hamartomas: long survival of a patient treated with repeated operations. (626934)
1978

Genetic Variations for Epithelioid Leiomyosarcoma

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Expression for genes affiliated with Epithelioid Leiomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Epithelioid Leiomyosarcoma

Search GEO for disease gene expression data for Epithelioid Leiomyosarcoma.

Pathways for genes affiliated with Epithelioid Leiomyosarcoma

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37NCBI BioSystems Database, 4Cell Signaling Technology, 53Reactome
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Pathways related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3DES, VIM
28.9ACTC1, DES, VIM
3
Hide members
8.9ACTC1, DES, VIM

Compounds for genes affiliated with Epithelioid Leiomyosarcoma

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1naphthol as-d chloroacetate449.8PTPRC, SERPINA3
2prostaglandin449.7VIM
3heparin44 28 11 2412.6SERPINA3, DES, PTPRC
4monochloroacetic acid449.5VIM, PTPRC
5silver449.5SERPINA3, DES, ENO2
62-methoxyethanol449.4VIM, ACTC1
7creatinine449.4ACTC1, PTHLH, SERPINA3
8orcein449.3ACTC1, VIM, DES
9acetylcholine44 49 28 11 2413.3ENO2, SERPINA3, PTHLH
10reticulin449.3ACTC1, DES, VIM
11mucicarmine449.3VIM, ACTC1, DES
12sialic acid449.2ENO2, SERPINA3, PTPRC
13biotin44 11 2411.2VIM, ACTC1, DES
14tartrate449.1PTHLH, VIM
15ibmx44 28 5911.0ENO2, PTPRC, PTHLH
16ionomycin449.0PTHLH, SERPINA3, PTPRC
17progestin449.0DES, VIM, PTHLH
18azathioprine44 49 2 1112.0PTHLH, DES, VIM
19dihydrotestosterone44 28 11 2411.9DES, VIM, PTHLH
20dbc-amp448.9PTHLH, VIM, ENO2
21heparan sulfate44 249.8DES, PTHLH, VIM
22s 100448.8VIM, DES, ACTC1, ENO2
23b 723448.8DES, PTPRC, VIM, ACTC1
24fmlp448.7VIM, PTPRC, SERPINA3
25methionine448.7VIM, DES, PTPRC, SERPINA3
26toluidine448.7VIM, DES, PTPRC, ENO2
27ganglioside448.7VIM, ENO2, DES, PTPRC
28hyaluronic acid44 249.6VIM, DES, PTPRC, ENO2
29dmso448.6PTPRC, VIM, ENO2
30estradiol44 11 2410.6SERPINA3, PTHLH, VIM, DES
31bromodeoxyuridine448.5ENO2, VIM, PTHLH, DES
3212-o-tetradecanoylphorbol 13-acetate448.5VIM, PTHLH, DES, PTPRC
33valine448.5SERPINA3, VIM, PTHLH
34oxygen44 249.5SERPINA3, PTHLH, ENO2, DES, ACTC1
35glucose448.4DES, ACTC1, PTHLH, ENO2, SERPINA3
36lactate448.4ENO2, VIM, DES, PTHLH
37adenylate448.4DES, ENO2, PTHLH, VIM
38steroid448.3PTHLH, SERPINA3, DES, ACTC1
39iron44 249.3ENO2, SERPINA3, ACTC1, DES, VIM
40hematoxylin448.3VIM, DES, ACTC1, PTPRC, ENO2
41formaldehyde44 249.3DES, VIM, ENO2, PTPRC, ACTC1
42vegf448.1ACTC1, PTHLH, ENO2, VIM, DES
43calcium44 49 11 2410.9DES, ENO2, SERPINA3, PTPRC, PTHLH, ACTC1
44lipid447.8PTHLH, VIM, PTPRC, SERPINA3, ENO2
45retinoic acid44 248.7SERPINA3, DES, ENO2, VIM, PTHLH, ACTC1
46glycogen44 248.6VIM, ENO2, PTPRC, PTHLH, DES, ACTC1
47testosterone44 59 11 2410.6PTHLH, PTPRC, ENO2, DES, VIM, ACTC1
48dexamethasone44 49 28 1110.5VIM, SERPINA3, ENO2, PTPRC, PTHLH, ACTC1
49paraffin447.2SERPINA3, ENO2, VIM, PTHLH, ACTC1, DES
50progesterone44 59 28 11 2411.2ENO2, SERPINA3, PTPRC, PTHLH, ACTC1, DES

GO Terms for genes affiliated with Epithelioid Leiomyosarcoma

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16Gene Ontology
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Biological processes related to Epithelioid Leiomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300498.9ACTC1, DES, VIM

Products for genes affiliated with Epithelioid Leiomyosarcoma

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Sources for Epithelioid Leiomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet