MCID: EPT011
MIFTS: 35

Epithelioid Leiomyosarcoma malady

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Epithelioid Leiomyosarcoma

Aliases & Descriptions for Epithelioid Leiomyosarcoma:

Name: Epithelioid Leiomyosarcoma 12 14
Leiomyosarcoma, Epithelioid 69
Leiomyosarcoma Epithelioid 52

Classifications:



External Ids:

Disease Ontology 12 DOID:5264
MeSH 42 D007890
NCIt 47 C3700
SNOMED-CT 64 42392001
UMLS 69 C0205815

Summaries for Epithelioid Leiomyosarcoma

MalaCards based summary : Epithelioid Leiomyosarcoma, also known as leiomyosarcoma, epithelioid, is related to uterine corpus epithelioid leiomyosarcoma and leiomyosarcoma. An important gene associated with Epithelioid Leiomyosarcoma is DES (Desmin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cytoskeleton remodeling Neurofilaments. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include uterus, cervix and skin.

Related Diseases for Epithelioid Leiomyosarcoma

Diseases related to Epithelioid Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 uterine corpus epithelioid leiomyosarcoma 12.0
2 leiomyosarcoma 10.6
3 inflammatory linear verrucous epidermal nevus 10.2 DES VIM
4 lymphomatous thyroiditis 10.2 DES VIM
5 malignant mixed mullerian tumor 10.2 DES ENO2
6 breast rhabdomyosarcoma 10.2 DES ENO2
7 marfanoid hypermobility syndrome 10.2 DES VIM
8 biliary papillomatosis 10.2 DES VIM
9 tanycytic ependymoma 10.2 DES VIM
10 liver angiosarcoma 10.2 DES VIM
11 cavernous sinus meningioma 10.2 DES VIM
12 male reproductive system disease 10.1 DES VIM
13 petrous apex meningioma 10.1 DES VIM
14 vulvar squamous papilloma 10.1 DES VIM
15 anal gland neoplasm 10.1 DES VIM
16 benign schwannoma 10.1 ENO2 VIM
17 autosomal recessive stickler syndrome 10.1 ENO2 VIM
18 nephrogenic adenoma of urinary bladder 10.1 ENO2 VIM
19 childhood medulloblastoma 10.1 DES ENO2
20 ossifying fibromyxoid tumor 10.1 ENO2 VIM
21 differentiating neuroblastoma 10.1 ENO2 VIM
22 childhood brain germinoma 10.1 ENO2 VIM
23 sengers syndrome 10.1 DES VIM
24 ovarian papillary neoplasm 10.1 ENO2 VIM
25 c-p angle neurinoma 10.1 DES VIM
26 breast squamous cell carcinoma 10.1 ENO2 VIM
27 mediastinum sarcoma 10.1 DES ENO2
28 central nervous system hemangioma 10.1 ENO2 VIM
29 anal squamous cell carcinoma 10.1 ENO2 SERPINA3
30 advanced sleep-phase syndrome, familial, 2 10.1 DES VIM
31 onychocytic matricoma 10.1 SERPINA3 VIM
32 rhabdomyosarcoma 2, alveolar 10.1 DES ENO2
33 central nervous system leiomyosarcoma 10.0 ENO2 SERPINA3
34 epimetaphyseal dysplasia cataract 10.0 ENO2 VIM
35 oral erosive lichen 10.0 ACTC1 DES
36 carbon monoxide-induced parkinsonism 10.0 ACTC1 DES
37 malignant adult ependymoma 10.0 SERPINA3 VIM
38 vagina leiomyosarcoma 10.0 ACTC1 DES
39 intestinal benign neoplasm 10.0 SERPINA3 VIM
40 episodic ataxia 10.0 ACTC1 DES
41 pustulosis palmaris et plantaris 10.0 ACTC1 DES
42 lymphomatoid papulosis 10.0 ACTC1 VIM
43 chest wall parachordoma 10.0 ACTC1 VIM
44 house allergic alveolitis 10.0 ACTC1 DES
45 tinea favosa 10.0 ACTC1 DES
46 conjunctival cancer 10.0 ACTC1 VIM
47 testicular granulosa cell tumor 10.0 ACTC1 VIM
48 palmoplantar keratosis 10.0 DES VIM
49 lymphangiosarcoma 10.0 ACTC1 VIM
50 gangliosidosis gm1 10.0 ACTC1 DES

Graphical network of the top 20 diseases related to Epithelioid Leiomyosarcoma:



Diseases related to Epithelioid Leiomyosarcoma

Symptoms & Phenotypes for Epithelioid Leiomyosarcoma

Drugs & Therapeutics for Epithelioid Leiomyosarcoma

Drugs for Epithelioid Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
3
Mechlorethamine Approved Phase 3,Phase 2,Phase 1 51-75-2 4033
4
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
5
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
6
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
8
Lenograstim Approved Phase 3,Phase 2 135968-09-1
9
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
10
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
11
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
12
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
13
Cyproheptadine Approved Phase 3 129-03-3 2913
14
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
15 Alkylating Agents Phase 3,Phase 2,Phase 1
16 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
17 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
18 Isophosphamide mustard Phase 3,Phase 2,Phase 1
19 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
20 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
21 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
22 Etoposide phosphate Phase 3,Phase 2
23 Anti-Infective Agents Phase 3,Phase 2
24 Immunosuppressive Agents Phase 3,Phase 2
25 Antimitotic Agents Phase 3,Phase 2
26 Antirheumatic Agents Phase 3,Phase 2
27 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
28
Histamine Phosphate Phase 3 51-74-1 65513
29
Serotonin Phase 3 50-67-9 5202
30 Serotonin Agents Phase 3
31 Serotonin Antagonists Phase 3
32 Gastrointestinal Agents Phase 3
33 Neurotransmitter Agents Phase 3
34 Histamine Antagonists Phase 3
35 Histamine H1 Antagonists Phase 3
36 Dermatologic Agents Phase 3
37 Anti-Allergic Agents Phase 3
38 Antipruritics Phase 3
39
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
40
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
41
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
42
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
43
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
44
Gemcitabine Approved Phase 2 95058-81-4 60750
45
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
46
Everolimus Approved Phase 2 159351-69-6 6442177
47
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
48
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
49
Nicotinamide Approved, Nutraceutical Phase 2 98-92-0 936
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037

Interventional clinical trials:

(show all 31)
id Name Status NCT ID Phase
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Unknown status NCT00346164 Phase 3
2 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3
3 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3
4 Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3
5 Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis Completed NCT00091351 Phase 3
6 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3
7 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3
8 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
9 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
10 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3
11 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2
12 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2
13 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
14 Sorafenib in Treating Patients With Metastatic, Locally Advanced, or Recurrent Sarcoma Completed NCT00245102 Phase 2
15 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2
16 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2
17 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2
18 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2
19 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2
20 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2
21 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2
22 Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma Subtypes Recruiting NCT02815995 Phase 2
23 Doxorubicin With Upfront Dexrazoxane Plus Olaratumab for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma Recruiting NCT02584309 Phase 2
24 Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma Active, not recruiting NCT01614795 Phase 2
25 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1
26 Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00030784 Phase 1
27 Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery Recruiting NCT03009201 Phase 1
28 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211
29 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
30 PET CT as Predictor of Response in Preoperative Chemotherapy for Soft Tissue Sarcoma Active, not recruiting NCT00346125
31 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984

Search NIH Clinical Center for Epithelioid Leiomyosarcoma

Genetic Tests for Epithelioid Leiomyosarcoma

Anatomical Context for Epithelioid Leiomyosarcoma

MalaCards organs/tissues related to Epithelioid Leiomyosarcoma:

39
Uterus, Cervix, Skin, Liver, Smooth Muscle, Lymph Node, Ovary

Publications for Epithelioid Leiomyosarcoma

Articles related to Epithelioid Leiomyosarcoma:

(show top 50) (show all 69)
id Title Authors Year
1
Epithelioid Leiomyosarcoma Arising in the Subcutis-A New Case Report of a Rare Variant. ( 23739249 )
2013
2
Cardiac epithelioid leiomyosarcoma as both intracardiac and pericardial mass with massive pericardial effusion: a rare presentation. ( 23916929 )
2013
3
Epithelioid leiomyosarcoma of uterus. ( 22602833 )
2012
4
A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. ( 21410837 )
2011
5
Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide. ( 21440979 )
2011
6
A rare case of primitive epithelioid leiomyosarcoma of the conjunctiva. ( 21574810 )
2011
7
Epithelioid leiomyosarcoma of the uterus: computed tomography findings. ( 20882890 )
2010
8
Cardiac epithelioid leiomyosarcoma and the role of cardiac imaging in the differentiation of intracardiac masses. ( 20552587 )
2010
9
Epithelioid leiomyosarcoma of the uterus containing sex cord-like elements. ( 19952934 )
2010
10
Epithelioid leiomyosarcoma with rhabdoid features. ( 17943409 )
2007
11
Primary extradural epithelioid leiomyosarcoma of the cervical spine: case report and literature review. ( 16094142 )
2005
12
Epithelioid leiomyosarcoma of the uterine cervix: a case report and review of the literature. ( 15890394 )
2005
13
Epithelioid leiomyosarcoma in the visceral peritoneum of an American badger (Taxidea taxus). ( 15690961 )
2005
14
Epithelioid leiomyosarcoma: case report and review of the literature. ( 16409271 )
2005
15
Epithelioid leiomyosarcoma of the ovary. ( 15863185 )
2005
16
Uterine epithelioid leiomyosarcomas with clear cells: reactivity with HMB-45 and the concept of PEComa. ( 15043315 )
2004
17
Epithelioid leiomyosarcoma of the external deep soft tissue. ( 12683863 )
2003
18
A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature. ( 12683897 )
2003
19
Primary paratesticular epithelioid leiomyosarcoma. ( 12740499 )
2003
20
Cytological diagnosis of metastatic epithelioid leiomyosarcoma to lymph node--a diagnostic dilemma. ( 14632734 )
2003
21
Epithelioid leiomyosarcoma of the gastrocolic ligament. ( 12658888 )
2003
22
Rhabdoid epithelioid leiomyosarcoma of the uterine corpus: a case report and literature review. ( 12232582 )
2002
23
Epithelioid leiomyosarcoma of the external deep soft tissue. ( 11900575 )
2002
24
Using thalidomide in a patient with epithelioid leiomyosarcoma and Osler-Weber-Rendu disease. ( 11831608 )
2002
25
Epithelioid leiomyosarcoma of the uterus with oncocytic change. ( 11569929 )
2001
26
Epithelioid leiomyosarcoma of the uterine cervix. ( 11531304 )
2001
27
Epithelioid leiomyosarcoma in a non-immunocompromised infant: additional differential diagnosis of pediatric "round cell tumors". ( 11048812 )
2000
28
Epithelioid leiomyosarcoma of the stomach: report of a case. ( 10714261 )
2000
29
Paraneoplastic pemphigus caused by an epithelioid leiomyosarcoma and associated with fatal respiratory failure. ( 10899680 )
2000
30
Epithelioid leiomyosarcoma with osteoclast-like giant cells in the rectum. ( 10705403 )
2000
31
Cytological findings of abdominal malignant leiomyoblastoma (epithelioid leiomyosarcoma) in ascitic fluid; a case report. ( 10588354 )
1999
32
Uterine malignant leiomyoblastoma (epithelioid leiomyosarcoma) during pregnancy. ( 10053121 )
1999
33
Primary epithelioid leiomyosarcoma of bone. Case report and literature review. ( 10335949 )
1999
34
Epithelioid leiomyosarcoma of the larynx. ( 9702545 )
1998
35
Epithelioid lymphangioleiomyomatosis-like tumour of the uterus in a patient without tuberous sclerosis: a lesion mimicking epithelioid leiomyosarcoma. ( 9726062 )
1998
36
Epithelioid leiomyosarcoma of the skin. ( 9563281 )
1998
37
Epithelioid leiomyosarcoma of the uterine cervix. ( 9512340 )
1998
38
Neuron-specific enolase-producing epithelioid leiomyosarcoma with gross vascular invasion and intracardiac involvement. ( 9870863 )
1998
39
Fine needle aspiration cytology of gastric epithelioid leiomyosarcoma metastasized to the liver. A case report. ( 9390146 )
1997
40
Primary multiple epithelioid leiomyosarcoma of the liver. ( 8975973 )
1996
41
Malignant plexiform tumor of the uterus: an unusual variant of epithelioid leiomyosarcoma. ( 8910640 )
1996
42
Uterine epithelioid leiomyosarcoma in a pig-tailed macaque. ( 9029402 )
1996
43
Gastric stump carcinoma occurring in a patient with Carney's triad 38 years after partial gastrectomy for epithelioid leiomyosarcoma. ( 7864713 )
1995
44
Differential alpha-smooth muscle actin expression in a gastric epithelioid leiomyosarcoma in a 14 year old girl. ( 8203266 )
1994
45
Epithelioid leiomyosarcoma of the skin and subcutaneous tissue. Clinicopathologic, immunohistochemical, and ultrastructural study of five cases. ( 8116792 )
1994
46
Epithelioid leiomyosarcoma of retroperitoneum with granular cell change. ( 7959652 )
1994
47
A case report of epithelioid leiomyosarcoma of transverse mesocolon: diagnosis and treatment. ( 8253608 )
1993
48
Epithelioid leiomyosarcoma of the breast: report of a case. ( 8104588 )
1993
49
Epithelioid leiomyosarcoma of the oral cavity: report of two cases and review of the literature. ( 8336232 )
1993
50
Subungual epithelioid leiomyosarcoma. ( 1585213 )
1992

Variations for Epithelioid Leiomyosarcoma

Expression for Epithelioid Leiomyosarcoma

Search GEO for disease gene expression data for Epithelioid Leiomyosarcoma.

Pathways for Epithelioid Leiomyosarcoma

Pathways related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.61 ACTC1 DES VIM
2
Show member pathways
11.29 DES VIM
3
Show member pathways
10.81 DES VIM
4 10.66 ACTC1 DES VIM

GO Terms for Epithelioid Leiomyosarcoma

Cellular components related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.02 ACTC1 DES ENO2 SERPINA3 VIM

Biological processes related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 8.96 DES VIM
2 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Epithelioid Leiomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 DES VIM

Sources for Epithelioid Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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