MCID: ERD001
MIFTS: 58

Erdheim-Chester Disease malady

Rare diseases, Bone diseases, Skin diseases categories

Aliases & Classifications for Erdheim-Chester Disease

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 47Orphanet, 60UMLS, 38NCIt, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Erdheim-Chester Disease, Aliases & Descriptions:

Name: Erdheim-Chester Disease 9 41 47 60
Erdheim Chester Disease 41
 
Lipoid Granulomatosis 41
Ecd 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

47
erdheim-chester disease:
Age of onset: Adult; Age of death: any age


External Ids:

Disease Ontology9 DOID:4329
NCIt38 C53972
MeSH33 D031249
Orphanet47 35687
MESH via Orphanet34 D031249
ICD10 via Orphanet26 D76.3
UMLS via Orphanet61 C0878675

Summaries for Erdheim-Chester Disease

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NIH Rare Diseases:41 Erdheim-chester disease is a rare condition that can affect many different organs of the body. this condition, which usually affects adults, is characterized by excessive production and accumulation of histiocytes (specific cells that normally play a role in responding to infection and injury) within multiple tissues and organs. as a result, these tissues and organs become thickened, dense and fibrotic. sites of involvement may include the long bones, skin, tissues behind the eyeballs, lungs, brain, and pituitary gland, among others. signs and symptoms, as well as disease course, depend on the specific location and extent of involvement. without successful treatment, organ failure can occur. last updated: 3/2/2010

MalaCards based summary: Erdheim-Chester Disease, also known as erdheim chester disease, is related to interstitial lung disease and periodontal disease, and has symptoms including abnormality of the genital system, proptosis and diabetes insipidus. An important gene associated with Erdheim-Chester Disease is CCR6 (chemokine (C-C motif) receptor 6), and among its related pathways are LDL Oxidation in Atherogenesis and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds ccl2 and [125i]ccl5 (human) have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and skin, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:63 Erdheim?Chester disease (also known as Erdheim?Chester syndrome or polyostotic sclerosing histiocytosis)... more...

Related Diseases for Erdheim-Chester Disease

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Diseases related to Erdheim-Chester Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1interstitial lung disease31.0IL1B, CCL2
2periodontal disease30.8CRP
3atopic dermatitis30.7CCL2, CCR3, CCL4
4hypopituitarism30.5SST, IGF1
5periodontitis30.5CCL2, CCR5, IL1B
6tuberculosis30.3CRP, IL1B, CCL4, CCR7
7leukemia30.1PRKG1, CCR7, CCR6, CCL4, IL1B
8adenoma30.0IGF1, BRAF, PRKG1, SST
9breast cancer29.6IGF1, BRAF, CCR7, CCR5, CCR6, CCL4
10atherosclerosis29.2IGF1, CCL2, CCR5, CCR3, CCL4, IL1B
11histiocytosis10.9
12langerhans-cell histiocytosis10.9
13cerebritis10.7
14pericardial effusion10.6
15diabetes insipidus10.6
16non-langerhans-cell histiocytosis10.6
17rosai-dorfman disease10.5S100B
18perineurioma10.5S100B
19malaria10.5PRKG1
20pericarditis10.4
21thyroiditis10.4
22ataxia10.4
23pilocytic astrocytoma10.4S100B
24bronchitis10.4CRP
25muckle-wells syndrome10.4IL1B
26clear cell sarcoma10.3S100B, BRAF
27precursor b-cell acute lymphoblastic leukemia10.3CCR7, CCR5, CCR6
28membranous glomerulonephritis, antenatal10.3CCR5, CCL2
29craniopharyngioma10.3IGF1
30hashimoto thyroiditis10.3
31multiple system atrophy10.3
32migraine10.3
33cerebellar ataxia10.3
34end stage renal failure10.3
35hematopoietic stem cell transplantation10.3
36thrombocytopenia10.3
37ureteral obstruction10.3
38familial hemiplegic migraine10.3
39portal hypertension10.3
40exophthalmos10.3
41constrictive pericarditis10.3
42schnitzler syndrome10.3
43rhinoscleroma10.3
44hydronephrosis10.3
45empty sella syndrome10.3
46amyloidosis10.3
47arthropathy10.3
48dermatitis10.3
49dystonia10.3
50nephrotic syndrome10.3

Graphical network of the top 20 diseases related to Erdheim-Chester Disease:



Diseases related to erdheim-chester disease

Symptoms for Erdheim-Chester Disease

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Symptoms:

 47 (show all 43)
  • proptosis/exophthalmos
  • hyperhidrosis/increased sweating
  • xanthomas/lipomas
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • diabetes insipidus
  • late puberty/hypogonadism/hypogenitalism
  • osteosclerosis/osteopetrosis/bone condensation
  • osteolysis/osteoclasia/bone destruction/erosions
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • bone pain
  • metaphyseal anomaly
  • epiphyseal anomaly
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • thirst
  • asthenia/fatigue/weakness
  • acute abdominal pain/colic
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • renal/kidney anomalies
  • megaureter/hydronephrosis/pyeloureteral junction syndrome
  • functional anomalies of the kidney and the urinary tract
  • hydrarthrosis/articular/joint effusion
  • mild visual loss/impaired visual acuity
  • nystagmus
  • ptosis
  • cutaneous rash
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • lung fibrosis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • heart/cardiac failure
  • renal failure
  • cerebellum/cerebellar vermis anomaly/agenesis/hypoplasia
  • ataxia/incoordination/trouble of the equilibrium
  • hypereflexia
  • elocution disorders/dysarthria/dysphonia
  • osteonecrosis/bone infarction
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • anaemia
  • early death/lethality

HPO human phenotypes related to Erdheim-Chester Disease:

(show all 34)
id Description Frequency HPO Source Accession
1 abnormality of the genital system hallmark (90%) HP:0000078
2 proptosis hallmark (90%) HP:0000520
3 diabetes insipidus hallmark (90%) HP:0000873
4 abnormality of the metaphyses hallmark (90%) HP:0000944
5 hyperhidrosis hallmark (90%) HP:0000975
6 multiple lipomas hallmark (90%) HP:0001012
7 weight loss hallmark (90%) HP:0001824
8 bone pain hallmark (90%) HP:0002653
9 osteomyelitis hallmark (90%) HP:0002754
10 osteolysis hallmark (90%) HP:0002797
11 abnormality of temperature regulation hallmark (90%) HP:0004370
12 abnormality of the epiphyses hallmark (90%) HP:0005930
13 increased bone mineral density hallmark (90%) HP:0011001
14 joint swelling typical (50%) HP:0001386
15 abnormality of the aortic valve typical (50%) HP:0001646
16 abdominal pain typical (50%) HP:0002027
17 renal insufficiency occasional (7.5%) HP:0000083
18 visual impairment occasional (7.5%) HP:0000505
19 ptosis occasional (7.5%) HP:0000508
20 nystagmus occasional (7.5%) HP:0000639
21 skin rash occasional (7.5%) HP:0000988
22 hyperreflexia occasional (7.5%) HP:0001347
23 congestive heart failure occasional (7.5%) HP:0001635
24 abnormality of the pericardium occasional (7.5%) HP:0001697
25 anemia occasional (7.5%) HP:0001903
26 nausea and vomiting occasional (7.5%) HP:0002017
27 respiratory insufficiency occasional (7.5%) HP:0002093
28 abnormality of the pleura occasional (7.5%) HP:0002103
29 neurological speech impairment occasional (7.5%) HP:0002167
30 pulmonary fibrosis occasional (7.5%) HP:0002206
31 incoordination occasional (7.5%) HP:0002311
32 aplasia/hypoplasia of the cerebellum occasional (7.5%) HP:0007360
33 aseptic necrosis occasional (7.5%) HP:0010885
34 abnormality of immune system physiology occasional (7.5%) HP:0010978

Drugs & Therapeutics for Erdheim-Chester Disease

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Drug clinical trials:

Search ClinicalTrials for Erdheim-Chester Disease

Search NIH Clinical Center for Erdheim-Chester Disease

Genetic Tests for Erdheim-Chester Disease

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Anatomical Context for Erdheim-Chester Disease

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MalaCards organs/tissues related to Erdheim-Chester Disease:

31
Bone, Lung, Skin, Brain, Pituitary, Bone marrow, Kidney, Cerebellum, Heart, Breast, Liver, Spinal cord, Lymph node, Thyroid, Testes, Endothelial

Animal Models for Erdheim-Chester Disease or affiliated genes

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MGI Mouse Phenotypes related to Erdheim-Chester Disease:

35 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3IGF1, BRAF, CCL2, CCR5, IL1B
2MP:00053818.1BRAF, PRKG1, SST, CCL2, CCR7, CCR5
3MP:00053757.9IGF1, BRAF, PRKG1, CCL2
4MP:00053867.9S100B, CCR5, CCL2, SST, PRKG1, BRAF
5MP:00053697.8IGF1, BRAF, PRKG1, CCL2, CCR5
6MP:00028737.5IGF1, BRAF, PRKG1, SST, CCL2, CCR6
7MP:00053847.4IGF1, BRAF, PRKG1, CCL2, CCR7, CCR5
8MP:00053857.1IGF1, BRAF, PRKG1, CCL2, CCR5, IL1B
9MP:00053976.8IGF1, BRAF, PRKG1, CCL2, CCR7, CCR5
10MP:00036316.7IGF1, BRAF, PRKG1, SST, CCL2, CCR7
11MP:00053876.1CRP, IGF1, BRAF, PRKG1, SST, CCL2
12MP:00053766.0SST, PRKG1, BRAF, IGF1, CCL2, CCR7

Publications for Erdheim-Chester Disease

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Articles related to Erdheim-Chester Disease:

(show top 50)    (show all 350)
idTitleAuthorsYear
1
Erdheim-Chester disease involving the breast--a rare but important differential diagnosis. (25454479)
2015
2
Hearing rehabilitation with a binaural cochlear implant in a patient with Erdheim-Chester disease. (25563401)
2015
3
Orbital MRI Pre- and Post-Vemurafenib Therapy for Erdheim-Chester Disease. (25886699)
2015
4
High-dose methotrexate for the treatment of relapsed central nervous system erdheim-chester disease. (25031876)
2014
5
Erdheim-Chester disease and knee pain in a dialysis patient. (25852919)
2014
6
Constrictive pericarditis in Erdheim-Chester disease: an integrated echocardiographic and magnetic resonance approach. (24768396)
2014
7
Gastrointestinal Erdheim-Chester disease. (24908861)
2014
8
Thoracic, abdominal and musculoskeletal involvement in Erdheim-Chester disease: CT, MR and PET imaging findings. (25017251)
2014
9
BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease. (25003820)
2014
10
Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to the BRAFV600E mutation. (24894769)
2014
11
Erdheim-Chester disease and Schnitzler syndrome: so near, and yet so far. (24046179)
2013
12
Erdheim-Chester disease: an uncommon cause of upper urinary tract obstruction. (24088590)
2013
13
Erdheim-Chester Disease With Prominent Pericardial Effusion: Cytologic Findings and Review of the Literature. (23447119)
2013
14
BRAF mutations in Erdheim-Chester disease. (23248255)
2013
15
Hand-SchA1ller-Christian disease and Erdheim-Chester disease: coexistence and discrepancy. (23299772)
2013
16
Paroxysmal exertion-induced dystonia secondary to Erdheim-Chester disease. (22980524)
2013
17
Erdheim-Chester disease. (23597965)
2013
18
Postoperative cardiac homograft involvement in Erdheim-Chester disease. (22808847)
2012
19
Histiocytosis for the neurologist: a case of Erdheim-Chester disease. (22976062)
2012
20
Pericardial effusion as a crucial presentation of Erdheim-Chester disease in a hemodialysis patient: an overlooked diagnosis. (22732342)
2012
21
Reply to commentary on "a case of erdheim-chester disease with asymptomatic renal involvement". (23341795)
2012
22
Erdheim-Chester disease with extensive coronary arterial involvement. (21566495)
2011
23
Erdheim-Chester disease: multisystem involvement and management with interferon-alpha. (19679354)
2010
24
Pulmonary involvement in Erdheim-Chester disease: a single-center study of thirty-four patients and a review of the literature. (20662053)
2010
25
A case of osteoarthropathy due to Erdheim-Chester disease with overlapping Langerhans' cell infiltration. (20558949)
2010
26
Non-Langerhans cell histiocytosis with isolated CNS involvement: an unusual variant of Erdheim-Chester disease. (20337948)
2010
27
Polyostotic sclerosing histiocytosis (Erdheim-Chester disease) treated with combined vertebroplasty and radiation therapy. (20968148)
2010
28
18F-fluorodeoxyglucose-positron emission tomography scanning is more useful in followup than in the initial assessment of patients with Erdheim-Chester disease. (19790052)
2009
29
A rare histiocytosis with severe cardiac involvement: Erdheim-Chester disease. (18717219)
2008
30
Unmasked diabetes insipidus after pericardial drainage and biopsy for pericardial effusion in association with Erdheim-Chester disease. (18603080)
2008
31
Intracranial lesion of Erdheim-Chester disease. (17509397)
2007
32
Tc-99m MDP bone scintigraphy and positron emission tomography/computed tomography (PET/CT) imaging in Erdheim-Chester disease. (17179801)
2007
33
Radiotherapy for Erdheim-Chester disease. (17566851)
2007
34
Laparoscopic biopsy and ureterolysis in Erdheim-Chester disease. (15819294)
2005
35
Diagnosis of Erdheim-Chester disease by using computerized tomography-guided stereotactic biopsy of a caudate lesion. Case report. (15352612)
2004
36
Erdheim-Chester disease mimicking a primary brain tumor. Case report. (15200134)
2004
37
Images in cardiovascular medicine. High resolution images obtained with ultrasound and magnetic resonance imaging of pericarotid fibrosis in Erdheim-Chester disease. (15477423)
2004
38
Erdheim-Chester disease. (12869045)
2003
39
Erdheim-Chester disease with early onset atherosclerosis and a pseudo-malignant phase. (12594120)
2003
40
Failure of radiation therapy for brain involvement in Erdheim Chester disease. (12241111)
2002
41
Interferon therapy for orbital infiltration secondary to Erdheim-Chester disease. (11730673)
2001
42
Erdheim-Chester disease. A case report. (11499297)
2001
43
Two enlarged kidneys: a manifestation of Erdheim-Chester disease. (11509804)
2001
44
Pulmonary involvement with Erdheim-Chester disease: radiographic and CT findings. (10789787)
2000
45
Erdheim-Chester disease with intramuscular lipogranuloma. (10855472)
2000
46
Erdheim-Chester disease: radiographic findings in five patients. (9554002)
1998
47
Erdheim-Chester disease: a case report with immunohistochemical and biochemical examination. (8543320)
1996
48
Erdheim-Chester disease with epiphyseal and systemic disease. (8320335)
1993
49
Langerhans cell histiocytosis with the radiographic findings of Erdheim-Chester disease. (3258103)
1988
50
Erdheim-Chester disease: computed tomography in two cases. (3923805)
1985

Variations for Erdheim-Chester Disease

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Expression for genes affiliated with Erdheim-Chester Disease

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Search GEO for disease gene expression data for Erdheim-Chester Disease.

Pathways for genes affiliated with Erdheim-Chester Disease

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Pathways related to Erdheim-Chester Disease according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL1B, CCL2
2
Show member pathways
9.3BRAF, CCR5, IL1B
3
Show member pathways
9.1S100B, IL1B, CCL4
4
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.1CCR5, CCL4, IL1B
5
Show member pathways
thioredoxin pathway36
9.1CRP, IL1B, CCL2
6
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.0IL1B, CCL4, CCL2
79.0IGF1, BRAF, IL1B
88.7PRKG1, BRAF, IGF1
9
Show member pathways
8.4CCL4, CCL2, CCR7, CCR5, CCR3, CCR6
10
Show member pathways
8.1SST, CCL2, CCR7, CCR5, CCR3, CCR6
11
Show member pathways
8.0BRAF, CCL2, CCR7, CCR5, CCR3, CCR6
12
Show member pathways
8.0BRAF, CCL2, CCR7, CCR5, CCR3, CCR6
13
Show member pathways
8.0IGF1, BRAF, CCL2, CCL4, IL1B
14
Show member pathways
7.5BRAF, CCL2, CCR7, CCR5, CCR3, CCR6
15
Show member pathways
7.3CCL4, CCR6, CCR3, CCR5, CCR7, CCL2
16
Show member pathways
7.3IGF1, IL1B, CCL4, CCR6, CCR3, CCR5
17
Show member pathways
6.9IGF1, BRAF, CCL2, CCR7, CCR5, CCR3
18
Show member pathways
6.0IGF1, BRAF, PRKG1, SST, CCL2, CCR7

Compounds for genes affiliated with Erdheim-Chester Disease

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Compounds related to Erdheim-Chester Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1ccl2289.9CCR3, CCR5
2[125i]ccl5 (human)289.9CCR3, CCR5
3mcp 1439.6CCL4, CCL2, CCR3
4turpentine439.5CRP, IL1B
5somatuline439.4IGF1, SST
6toxin-1439.4CCL4, IL1B, CCL2
7mdms439.4CCR5, CCL2, CCL4, S100B
8omeprazole43 49 28 24 1213.3SST, IL1B, CRP
9sulfasalazine28 43 49 1212.3CRP, IL1B, CCL2
10muramyl tripeptide439.2IL1B, CCL2
11triptolide439.2IL1B, CCR7, CCL2, CCL4
12larc439.1CCL4, CCL2, CCR7, CCR5, CCR6
13mip 1alpha439.1CCR5, IL1B, CCL2, CCL4
14groalpha439.1IL1B, CCL2, CCR5, CCL4
15il 10439.1CCR5, CCL4, CCL2, IL1B
16simvastatin43 49 59 28 24 1214.0CCL2, CCL4, CRP, CCR5
17ivig439.0CCL4, CRP, CCR5, IL1B
18norepinephrine43 24 1211.0S100B, CRP, CCR7, CCL2, SST
19nitroglycerin43 1210.0PRKG1, SST, CRP
20tarc438.9CCR6, CCR5, CCL2, CCR7, CCR3, CCL4
21acth438.8SST, IL1B, IGF1, S100B
22endotoxin438.8CCL2, CCL4, IL1B, CRP
23rapamycin438.7IGF1, BRAF, SST, CRP, CCR5
24glutamine438.7S100B, CRP, CCR5, CCL2, IGF1
25actinomycin d438.6IL1B, IGF1, CCL2, CCR5, CCR3
26genistein43 28 59 2 24 1213.6IL1B, CCL2, IGF1, SST, CCR3
27ccl343 289.6CCL2, CCR7, CCR5, CCR3, CCL4, IL1B
28ccl443 289.6CCR6, CCL2, CCR7, CCR5, CCR3, CCL4
29histamine43 28 2410.5IL1B, CCL4, CCR3, CCR5, CCL2, SST
30pge2438.5SST, CCL2, CCR5, CCL4, IL1B, CCR7
31ly294002438.4IL1B, CCL2, IGF1, CRP, BRAF
32arginine438.4CCR5, S100B, SST, BRAF, IGF1, CCL2
33creatinine438.4CCL2, CRP, CCL4, IGF1, S100B
34wortmannin438.4BRAF, CCL2, CCR3, CCL4, S100B, IGF1
35pd 98,059438.4BRAF, CCL2, CCL4, IL1B, IGF1
36alanine438.3CCR7, BRAF, CCL4, CCR5, CCR3, S100B
37rantes438.3CCL2, CCR7, CCR5, CCR3, CCR6, CCL4
38aspartate438.2CRP, BRAF, PRKG1, S100B, CCR5, CCL2
39thymidine43 249.2S100B, CCR3, PRKG1, IGF1, IL1B
40sb 20358043 599.0IGF1, BRAF, CCL2, CCL4, IL1B, CRP
41cycloheximide438.0CRP, IL1B, CCL4, CCL2, SST, IGF1
42testosterone43 59 24 1210.9S100B, CCL2, SST, PRKG1, CRP, IGF1
43lipid437.7BRAF, PRKG1, CCL2, CCR7, CCR3, CCR6
44retinoic acid43 248.6CCR5, CCL4, S100B, IL1B, IGF1, BRAF
45dexamethasone43 49 28 1210.6CCR3, S100B, SST, CCL2, CCR5, CCL4
46glucose437.5SST, PRKG1, BRAF, IGF1, S100B, CRP
47serine437.4IGF1, PRKG1, CCL2, CCR5, CCL4, S100B
48tyrosine437.3PRKG1, IGF1, S100B, CCR7, CCR5, CCR3
49calcium43 49 24 129.9PRKG1, CRP, CCR6, CCR3, CCR5, CCR7
50vegf436.3PRKG1, S100B, CRP, IL1B, CCL4, CCR6

GO Terms for genes affiliated with Erdheim-Chester Disease

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Cellular components related to Erdheim-Chester Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430259.4S100B, CCL2, SST
2extracellular spaceGO:00056157.3S100B, IGF1, SST, CCL2, CCL4, IL1B
3plasma membraneGO:00058867.2IGF1, BRAF, PRKG1, CCR7, CCR5, CCR3
4extracellular regionGO:00055767.2IGF1, SST, CCL2, CCL4, IL1B, CRP

Biological processes related to Erdheim-Chester Disease according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1dendritic cell chemotaxisGO:000240710.0CCR6, CCR5, CCR7
2response to amino acidGO:00432009.9SST, CCL2
3cellular defense responseGO:00069689.9CCR5, CCR3, CCR6
4cellular response to calcium ionGO:00712779.8CRP, BRAF
5lipopolysaccharide-mediated signaling pathwayGO:00316639.7IL1B, CCL2
6response to heatGO:00094089.7CCL2, SST
7protein kinase B signalingGO:00434919.7CCL2, IL1B
8positive regulation of cytosolic calcium ion concentrationGO:00072049.7CCR7, CCR5, CCR3, CCR6
9positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.6S100B, IL1B, CCR7
10cell surface receptor signaling pathwayGO:00071669.6CCR5, CCL2, SST
11cellular response to organic cyclic compoundGO:00714079.6CCL2, IL1B
12chemotaxisGO:00069359.5CCR6, CCR3, CCR5, CCL2
13blood vessel remodelingGO:00019749.5CCR5, IGF1
14MAPK cascadeGO:00001659.5IL1B, CCR5, CCL2
15positive regulation of mitosisGO:00458409.5IL1B, IGF1
16G-protein coupled receptor signaling pathwayGO:00071869.4CCR5, CCR7, CCL2, SST
17cellular component movementGO:00069289.3IGF1, CCR6, CCL4
18chemokine-mediated signaling pathwayGO:00700989.3CCR6, CCR3, CCR5, CCR7, CCL2
19neutrophil chemotaxisGO:00305939.2IL1B, CCL2
20extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.2IL1B, IGF1
21cell-cell signalingGO:00072679.1IL1B, CCL4, CCR5, SST
22immune responseGO:00069558.9CCR7, CCR5, CCR6, CCL4, IL1B
23inflammatory responseGO:00069548.0CCL2, CCR7, CCR5, CCR3, CCL4, IL1B
24signal transductionGO:00071657.6IGF1, PRKG1, CCL2, CCR6, CCL4, IL1B

Molecular functions related to Erdheim-Chester Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00049509.6CCR6, CCR3, CCR5
2C-C chemokine receptor activityGO:00164939.1CCR6, CCR3, CCR5, CCR7

Products for genes affiliated with Erdheim-Chester Disease

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Sources for Erdheim-Chester Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet