MCID: ERD001
MIFTS: 67

Erdheim-Chester Disease malady

Rare diseases, Bone diseases, Skin diseases categories

Summaries for Erdheim-Chester Disease

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NIH Rare Diseases:43 Erdheim-chester disease is a rare condition that can affect many different organs of the body. this condition, which usually affects adults, is characterized by excessive production and accumulation of histiocytes (specific cells that normally play a role in responding to infection and injury) within multiple tissues and organs. as a result, these tissues and organs become thickened, dense and fibrotic. sites of involvement may include the long bones, skin, tissues behind the eyeballs, lungs, brain, and pituitary gland, among others. signs and symptoms, as well as disease course, depend on the specific location and extent of involvement. without successful treatment, organ failure can occur. last updated: 3/2/2010

MalaCards based summary: Erdheim-Chester Disease, also known as erdheim chester disease, is related to interstitial lung disease and periodontal disease, and has symptoms including abnormality of the genital system, proptosis and diabetes insipidus. An important gene associated with Erdheim-Chester Disease is CCR6 (chemokine (C-C motif) receptor 6), and among its related pathways are LDL Oxidation in Atherogenesis and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds ccl2 and [125i]ccl5 (human) have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and skin, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Wikipedia:65 Erdheim?Chester disease (also known as Erdheim?Chester syndrome or polyostotic sclerosing histiocytosis)... more...

Aliases & Classifications for Erdheim-Chester Disease

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 49Orphanet, 62UMLS, 40NCIt, 35MeSH, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Erdheim-Chester Disease, Aliases & Descriptions:

Name: Erdheim-Chester Disease 10 43 49 62
Erdheim Chester Disease 43
 
Lipoid Granulomatosis 43
Ecd 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

49
erdheim-chester disease:
Age of onset: Adult; Age of death: any age


External Ids:

Disease Ontology10 DOID:4329
NCIt40 C53972
MeSH35 D031249
Orphanet49 35687
MESH via Orphanet36 D031249
ICD10 via Orphanet28 D76.3
UMLS via Orphanet63 C0878675

Related Diseases for Erdheim-Chester Disease

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Diseases related to Erdheim-Chester Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1interstitial lung disease30.8IL1B, CCL2
2periodontal disease30.4CRP
3atopic dermatitis30.4CCL2, CCR3, CCL4
4hypopituitarism30.4SST, IGF1
5periodontitis30.4CCL2, CCR5, IL1B
6tuberculosis30.4CRP, IL1B, CCL4, CCR7
7leukemia30.4PRKG1, CCR7, CCR6, CCL4, IL1B
8adenoma30.3IGF1, BRAF, PRKG1, SST
9atherosclerosis30.3IGF1, CCL2, CCR5, CCR3, CCL4, IL1B
10breast cancer30.1IGF1, BRAF, CCR7, CCR5, CCR6, CCL4
11histiocytosis10.9
12langerhans-cell histiocytosis10.9
13cerebritis10.7
14pericardial effusion10.6
15diabetes insipidus10.6
16non-langerhans-cell histiocytosis10.6
17pericarditis10.4
18thyroiditis10.4
19ataxia10.4
20hashimoto thyroiditis10.3
21multiple system atrophy10.3
22migraine10.3
23cerebellar ataxia10.3
24end stage renal failure10.3
25hematopoietic stem cell transplantation10.3
26thrombocytopenia10.3
27ureteral obstruction10.3
28familial hemiplegic migraine10.3
29portal hypertension10.3
30exophthalmos10.3
31constrictive pericarditis10.3
32schnitzler syndrome10.3
33rhinoscleroma10.3
34hydronephrosis10.3
35empty sella syndrome10.3
36amyloidosis10.3
37arthropathy10.3
38dermatitis10.3
39dystonia10.3
40nephrotic syndrome10.3
41panniculitis10.3
42paraplegia10.3
43periostitis10.3
44pneumothorax10.3
45urinary tract obstruction10.3
46hemiplegic migraine10.3
47lipogranulomatosis10.3
48retroperitoneal fibrosis10.3
49dysphagia10.3
50neurosarcoidosis10.3

Graphical network of the top 20 diseases related to Erdheim-Chester Disease:



Diseases related to erdheim-chester disease

Symptoms for Erdheim-Chester Disease

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Symptoms:

 49 (show all 43)
  • proptosis/exophthalmos
  • hyperhidrosis/increased sweating
  • xanthomas/lipomas
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • diabetes insipidus
  • late puberty/hypogonadism/hypogenitalism
  • osteosclerosis/osteopetrosis/bone condensation
  • osteolysis/osteoclasia/bone destruction/erosions
  • osteomyelitis/osteitis/periostitis/spondylodisciitis
  • bone pain
  • metaphyseal anomaly
  • epiphyseal anomaly
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • thirst
  • asthenia/fatigue/weakness
  • acute abdominal pain/colic
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • renal/kidney anomalies
  • megaureter/hydronephrosis/pyeloureteral junction syndrome
  • functional anomalies of the kidney and the urinary tract
  • hydrarthrosis/articular/joint effusion
  • mild visual loss/impaired visual acuity
  • nystagmus
  • ptosis
  • cutaneous rash
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • ground-glass/reticular/alveolar/interstitial lung/pulmonary opacity
  • lung fibrosis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cough
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • heart/cardiac failure
  • renal failure
  • cerebellum/cerebellar vermis anomaly/agenesis/hypoplasia
  • ataxia/incoordination/trouble of the equilibrium
  • hypereflexia
  • elocution disorders/dysarthria/dysphonia
  • osteonecrosis/bone infarction
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • anaemia
  • early death/lethality

HPO human phenotypes related to Erdheim-Chester Disease:

(show all 34)
id Description Frequency HPO Source Accession
1 abnormality of the genital system hallmark (90%) HP:0000078
2 proptosis hallmark (90%) HP:0000520
3 diabetes insipidus hallmark (90%) HP:0000873
4 abnormality of the metaphyses hallmark (90%) HP:0000944
5 hyperhidrosis hallmark (90%) HP:0000975
6 multiple lipomas hallmark (90%) HP:0001012
7 weight loss hallmark (90%) HP:0001824
8 bone pain hallmark (90%) HP:0002653
9 osteomyelitis hallmark (90%) HP:0002754
10 osteolysis hallmark (90%) HP:0002797
11 abnormality of temperature regulation hallmark (90%) HP:0004370
12 abnormality of the epiphyses hallmark (90%) HP:0005930
13 increased bone mineral density hallmark (90%) HP:0011001
14 joint swelling typical (50%) HP:0001386
15 abnormality of the aortic valve typical (50%) HP:0001646
16 abdominal pain typical (50%) HP:0002027
17 renal insufficiency occasional (7.5%) HP:0000083
18 visual impairment occasional (7.5%) HP:0000505
19 ptosis occasional (7.5%) HP:0000508
20 nystagmus occasional (7.5%) HP:0000639
21 skin rash occasional (7.5%) HP:0000988
22 hyperreflexia occasional (7.5%) HP:0001347
23 congestive heart failure occasional (7.5%) HP:0001635
24 abnormality of the pericardium occasional (7.5%) HP:0001697
25 anemia occasional (7.5%) HP:0001903
26 nausea and vomiting occasional (7.5%) HP:0002017
27 respiratory insufficiency occasional (7.5%) HP:0002093
28 abnormality of the pleura occasional (7.5%) HP:0002103
29 neurological speech impairment occasional (7.5%) HP:0002167
30 pulmonary fibrosis occasional (7.5%) HP:0002206
31 incoordination occasional (7.5%) HP:0002311
32 aplasia/hypoplasia of the cerebellum occasional (7.5%) HP:0007360
33 aseptic necrosis occasional (7.5%) HP:0010885
34 abnormality of immune system physiology occasional (7.5%) HP:0010978

Drugs & Therapeutics for Erdheim-Chester Disease

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Drug clinical trials:

Search ClinicalTrials for Erdheim-Chester Disease

Search NIH Clinical Center for Erdheim-Chester Disease

Genetic Tests for Erdheim-Chester Disease

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Anatomical Context for Erdheim-Chester Disease

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MalaCards organs/tissues related to Erdheim-Chester Disease:

33
Bone, Lung, Skin, Brain, Pituitary, Bone marrow, Kidney, Cerebellum, Heart, Breast, Liver, Spinal cord, Lymph node, Thyroid, Testes, Endothelial

Animal Models for Erdheim-Chester Disease or affiliated genes

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MGI Mouse Phenotypes related to Erdheim-Chester Disease:

37 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3IGF1, BRAF, CCL2, CCR5, IL1B
2MP:00053818.1BRAF, PRKG1, SST, CCL2, CCR7, CCR5
3MP:00053757.9IGF1, BRAF, PRKG1, CCL2
4MP:00053867.9S100B, CCR5, CCL2, SST, PRKG1, BRAF
5MP:00053697.8IGF1, BRAF, PRKG1, CCL2, CCR5
6MP:00028737.5IGF1, BRAF, PRKG1, SST, CCL2, CCR6
7MP:00053847.4IGF1, BRAF, PRKG1, CCL2, CCR7, CCR5
8MP:00053857.1IGF1, BRAF, PRKG1, CCL2, CCR5, IL1B
9MP:00053976.8IGF1, BRAF, PRKG1, CCL2, CCR7, CCR5
10MP:00036316.7IGF1, BRAF, PRKG1, SST, CCL2, CCR7
11MP:00053876.1CRP, IGF1, BRAF, PRKG1, SST, CCL2
12MP:00053766.0SST, PRKG1, BRAF, IGF1, CCL2, CCR7

Publications for Erdheim-Chester Disease

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Articles related to Erdheim-Chester Disease:

(show top 50)    (show all 350)
idTitleAuthorsYear
1
Erdheim-Chester disease involving the breast--a rare but important differential diagnosis. (25454479)
2015
2
Hearing rehabilitation with a binaural cochlear implant in a patient with Erdheim-Chester disease. (25563401)
2015
3
Orbital MRI Pre- and Post-Vemurafenib Therapy for Erdheim-Chester Disease. (25886699)
2015
4
High-dose methotrexate for the treatment of relapsed central nervous system erdheim-chester disease. (25031876)
2014
5
Erdheim-Chester disease and knee pain in a dialysis patient. (25852919)
2014
6
Constrictive pericarditis in Erdheim-Chester disease: an integrated echocardiographic and magnetic resonance approach. (24768396)
2014
7
Gastrointestinal Erdheim-Chester disease. (24908861)
2014
8
Thoracic, abdominal and musculoskeletal involvement in Erdheim-Chester disease: CT, MR and PET imaging findings. (25017251)
2014
9
BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease. (25003820)
2014
10
Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to the BRAFV600E mutation. (24894769)
2014
11
Erdheim-Chester disease and Schnitzler syndrome: so near, and yet so far. (24046179)
2013
12
Erdheim-Chester disease: an uncommon cause of upper urinary tract obstruction. (24088590)
2013
13
Erdheim-Chester Disease With Prominent Pericardial Effusion: Cytologic Findings and Review of the Literature. (23447119)
2013
14
BRAF mutations in Erdheim-Chester disease. (23248255)
2013
15
Hand-SchA1ller-Christian disease and Erdheim-Chester disease: coexistence and discrepancy. (23299772)
2013
16
Paroxysmal exertion-induced dystonia secondary to Erdheim-Chester disease. (22980524)
2013
17
Erdheim-Chester disease. (23597965)
2013
18
Postoperative cardiac homograft involvement in Erdheim-Chester disease. (22808847)
2012
19
Histiocytosis for the neurologist: a case of Erdheim-Chester disease. (22976062)
2012
20
Pericardial effusion as a crucial presentation of Erdheim-Chester disease in a hemodialysis patient: an overlooked diagnosis. (22732342)
2012
21
Reply to commentary on "a case of erdheim-chester disease with asymptomatic renal involvement". (23341795)
2012
22
Erdheim-Chester disease with extensive coronary arterial involvement. (21566495)
2011
23
Erdheim-Chester disease: multisystem involvement and management with interferon-alpha. (19679354)
2010
24
Pulmonary involvement in Erdheim-Chester disease: a single-center study of thirty-four patients and a review of the literature. (20662053)
2010
25
A case of osteoarthropathy due to Erdheim-Chester disease with overlapping Langerhans' cell infiltration. (20558949)
2010
26
Non-Langerhans cell histiocytosis with isolated CNS involvement: an unusual variant of Erdheim-Chester disease. (20337948)
2010
27
Polyostotic sclerosing histiocytosis (Erdheim-Chester disease) treated with combined vertebroplasty and radiation therapy. (20968148)
2010
28
18F-fluorodeoxyglucose-positron emission tomography scanning is more useful in followup than in the initial assessment of patients with Erdheim-Chester disease. (19790052)
2009
29
A rare histiocytosis with severe cardiac involvement: Erdheim-Chester disease. (18717219)
2008
30
Unmasked diabetes insipidus after pericardial drainage and biopsy for pericardial effusion in association with Erdheim-Chester disease. (18603080)
2008
31
Intracranial lesion of Erdheim-Chester disease. (17509397)
2007
32
Tc-99m MDP bone scintigraphy and positron emission tomography/computed tomography (PET/CT) imaging in Erdheim-Chester disease. (17179801)
2007
33
Radiotherapy for Erdheim-Chester disease. (17566851)
2007
34
Laparoscopic biopsy and ureterolysis in Erdheim-Chester disease. (15819294)
2005
35
Diagnosis of Erdheim-Chester disease by using computerized tomography-guided stereotactic biopsy of a caudate lesion. Case report. (15352612)
2004
36
Erdheim-Chester disease mimicking a primary brain tumor. Case report. (15200134)
2004
37
Images in cardiovascular medicine. High resolution images obtained with ultrasound and magnetic resonance imaging of pericarotid fibrosis in Erdheim-Chester disease. (15477423)
2004
38
Erdheim-Chester disease. (12869045)
2003
39
Erdheim-Chester disease with early onset atherosclerosis and a pseudo-malignant phase. (12594120)
2003
40
Failure of radiation therapy for brain involvement in Erdheim Chester disease. (12241111)
2002
41
Interferon therapy for orbital infiltration secondary to Erdheim-Chester disease. (11730673)
2001
42
Erdheim-Chester disease. A case report. (11499297)
2001
43
Two enlarged kidneys: a manifestation of Erdheim-Chester disease. (11509804)
2001
44
Pulmonary involvement with Erdheim-Chester disease: radiographic and CT findings. (10789787)
2000
45
Erdheim-Chester disease with intramuscular lipogranuloma. (10855472)
2000
46
Erdheim-Chester disease: radiographic findings in five patients. (9554002)
1998
47
Erdheim-Chester disease: a case report with immunohistochemical and biochemical examination. (8543320)
1996
48
Erdheim-Chester disease with epiphyseal and systemic disease. (8320335)
1993
49
Langerhans cell histiocytosis with the radiographic findings of Erdheim-Chester disease. (3258103)
1988
50
Erdheim-Chester disease: computed tomography in two cases. (3923805)
1985

Variations for Erdheim-Chester Disease

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Expression for genes affiliated with Erdheim-Chester Disease

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Search GEO for disease gene expression data for Erdheim-Chester Disease.

Pathways for genes affiliated with Erdheim-Chester Disease

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Pathways related to Erdheim-Chester Disease according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL1B, CCL2
2
Show member pathways
Peptide GPCRs38
9.4CCR6, CCR3, CCR5, CCR7
3
Show member pathways
9.3BRAF, CCR5, IL1B
4
Show member pathways
9.1S100B, IL1B, CCL4
5
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.1CCR5, CCL4, IL1B
6
Show member pathways
thioredoxin pathway38
9.1CRP, IL1B, CCL2
7
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.0IL1B, CCL4, CCL2
89.0IGF1, BRAF, IL1B
98.7PRKG1, BRAF, IGF1
10
Show member pathways
8.4CCL4, CCL2, CCR7, CCR5, CCR3, CCR6
11
Show member pathways
8.1SST, CCL2, CCR7, CCR5, CCR3, CCR6
12
Show member pathways
8.0BRAF, CCL2, CCR7, CCR5, CCR3, CCR6
13
Show member pathways
8.0BRAF, CCL2, CCR7, CCR5, CCR3, CCR6
14
Show member pathways
8.0IGF1, BRAF, CCL2, CCL4, IL1B
15
Show member pathways
7.5BRAF, CCL2, CCR7, CCR5, CCR3, CCR6
16
Show member pathways
7.3CCL4, CCR6, CCR3, CCR5, CCR7, CCL2
17
Show member pathways
7.3IGF1, IL1B, CCL4, CCR6, CCR3, CCR5
18
Show member pathways
6.9IGF1, BRAF, CCL2, CCR7, CCR5, CCR3
19
Show member pathways
6.0IGF1, BRAF, PRKG1, SST, CCL2, CCR7

Compounds for genes affiliated with Erdheim-Chester Disease

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Compounds related to Erdheim-Chester Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 138)
idCompoundScoreTop Affiliating Genes
1ccl2309.9CCR3, CCR5
2[125i]ccl5 (human)309.9CCR3, CCR5
3mcp 1459.6CCL4, CCL2, CCR3
4turpentine459.5CRP, IL1B
5somatuline459.4IGF1, SST
6toxin-1459.4CCL4, IL1B, CCL2
7mdms459.4CCR5, CCL2, CCL4, S100B
8omeprazole45 51 30 26 1313.3SST, IL1B, CRP
9sulfasalazine30 45 51 1312.3CRP, IL1B, CCL2
10muramyl tripeptide459.2IL1B, CCL2
11triptolide459.2IL1B, CCR7, CCL2, CCL4
12larc459.1CCL4, CCL2, CCR7, CCR5, CCR6
13mip 1alpha459.1CCR5, IL1B, CCL2, CCL4
14groalpha459.1IL1B, CCL2, CCR5, CCL4
15il 10459.1CCR5, CCL4, CCL2, IL1B
16simvastatin45 51 61 30 26 1314.0CCL2, CCL4, CRP, CCR5
17ivig459.0CCL4, CRP, CCR5, IL1B
18norepinephrine45 26 1311.0S100B, CRP, CCR7, CCL2, SST
19nitroglycerin45 1310.0PRKG1, SST, CRP
20tarc458.9CCR6, CCR5, CCL2, CCR7, CCR3, CCL4
21acth458.8SST, IL1B, IGF1, S100B
22endotoxin458.8CCL2, CCL4, IL1B, CRP
23rapamycin458.7IGF1, BRAF, SST, CRP, CCR5
24glutamine458.7S100B, CRP, CCR5, CCL2, IGF1
25actinomycin d458.6IL1B, IGF1, CCL2, CCR5, CCR3
26genistein45 30 61 3 26 1313.6IL1B, CCL2, IGF1, SST, CCR3
27ccl345 309.6CCL2, CCR7, CCR5, CCR3, CCL4, IL1B
28ccl445 309.6CCR6, CCL2, CCR7, CCR5, CCR3, CCL4
29histamine45 30 2610.5IL1B, CCL4, CCR3, CCR5, CCL2, SST
30pge2458.5SST, CCL2, CCR5, CCL4, IL1B, CCR7
31ly294002458.4IL1B, CCL2, IGF1, CRP, BRAF
32arginine458.4CCR5, S100B, SST, BRAF, IGF1, CCL2
33creatinine458.4CCL2, CRP, CCL4, IGF1, S100B
34wortmannin458.4BRAF, CCL2, CCR3, CCL4, S100B, IGF1
35pd 98,059458.4BRAF, CCL2, CCL4, IL1B, IGF1
36alanine458.3CCR7, BRAF, CCL4, CCR5, CCR3, S100B
37rantes458.3CCL2, CCR7, CCR5, CCR3, CCR6, CCL4
38aspartate458.2CRP, BRAF, PRKG1, S100B, CCR5, CCL2
39thymidine45 269.2S100B, CCR3, PRKG1, IGF1, IL1B
40sb 20358045 619.0IGF1, BRAF, CCL2, CCL4, IL1B, CRP
41cycloheximide458.0CRP, IL1B, CCL4, CCL2, SST, IGF1
42testosterone45 61 26 1310.9S100B, CCL2, SST, PRKG1, CRP, IGF1
43lipid457.7BRAF, PRKG1, CCL2, CCR7, CCR3, CCR6
44retinoic acid45 268.6CCR5, CCL4, S100B, IL1B, IGF1, BRAF
45dexamethasone45 51 30 1310.6CCR3, S100B, SST, CCL2, CCR5, CCL4
46glucose457.5SST, PRKG1, BRAF, IGF1, S100B, CRP
47serine457.4IGF1, PRKG1, CCL2, CCR5, CCL4, S100B
48tyrosine457.3PRKG1, IGF1, S100B, CCR7, CCR5, CCR3
49calcium45 51 26 139.9PRKG1, CRP, CCR6, CCR3, CCR5, CCR7
50vegf456.3PRKG1, S100B, CRP, IL1B, CCL4, CCR6

GO Terms for genes affiliated with Erdheim-Chester Disease

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Cellular components related to Erdheim-Chester Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430259.4S100B, CCL2, SST
2extracellular spaceGO:00056157.3S100B, IGF1, SST, CCL2, CCL4, IL1B
3plasma membraneGO:00058867.2IGF1, BRAF, PRKG1, CCR7, CCR5, CCR3
4extracellular regionGO:00055767.2IGF1, SST, CCL2, CCL4, IL1B, CRP

Biological processes related to Erdheim-Chester Disease according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1dendritic cell chemotaxisGO:000240710.0CCR6, CCR5, CCR7
2response to amino acidGO:00432009.9SST, CCL2
3cellular defense responseGO:00069689.9CCR5, CCR3, CCR6
4cellular response to calcium ionGO:00712779.8CRP, BRAF
5lipopolysaccharide-mediated signaling pathwayGO:00316639.7IL1B, CCL2
6response to heatGO:00094089.7CCL2, SST
7protein kinase B signalingGO:00434919.7CCL2, IL1B
8positive regulation of cytosolic calcium ion concentrationGO:00072049.7CCR7, CCR5, CCR3, CCR6
9positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.6S100B, IL1B, CCR7
10cell surface receptor signaling pathwayGO:00071669.6CCR5, CCL2, SST
11cellular response to organic cyclic compoundGO:00714079.6CCL2, IL1B
12chemotaxisGO:00069359.5CCR6, CCR3, CCR5, CCL2
13blood vessel remodelingGO:00019749.5CCR5, IGF1
14MAPK cascadeGO:00001659.5IL1B, CCR5, CCL2
15positive regulation of mitosisGO:00458409.5IL1B, IGF1
16G-protein coupled receptor signaling pathwayGO:00071869.4CCR5, CCR7, CCL2, SST
17cellular component movementGO:00069289.3IGF1, CCR6, CCL4
18chemokine-mediated signaling pathwayGO:00700989.3CCR6, CCR3, CCR5, CCR7, CCL2
19neutrophil chemotaxisGO:00305939.2IL1B, CCL2
20extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.2IL1B, IGF1
21cell-cell signalingGO:00072679.1IL1B, CCL4, CCR5, SST
22immune responseGO:00069558.9CCR7, CCR5, CCR6, CCL4, IL1B
23inflammatory responseGO:00069548.0CCL2, CCR7, CCR5, CCR3, CCL4, IL1B
24signal transductionGO:00071657.6IGF1, PRKG1, CCL2, CCR6, CCL4, IL1B

Molecular functions related to Erdheim-Chester Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor activityGO:00049509.6CCR6, CCR3, CCR5
2C-C chemokine receptor activityGO:00164939.1CCR6, CCR3, CCR5, CCR7

Products for genes affiliated with Erdheim-Chester Disease

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Sources for Erdheim-Chester Disease

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet