MCID: ERY004
MIFTS: 43

Erysipelas

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Erysipelas

MalaCards integrated aliases for Erysipelas:

Name: Erysipelas 12 72 49 28 51 41 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11330
ICD10 32 A46
ICD9CM 34 035
MeSH 41 D004886
UMLS 69 C0014733

Summaries for Erysipelas

MalaCards based summary : Erysipelas is related to elephantiasis and brucellosis, and has symptoms including exanthema An important gene associated with Erysipelas is PI3 (Peptidase Inhibitor 3), and among its related pathways/superpathways are Defensins and amb2 Integrin signaling. The drugs Penicillin V and Daptomycin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and colon.

Wikipedia : 72 Erysipelas is an acute infection typically with a skin rash, usually on any of the legs and toes, face,... more...

Related Diseases for Erysipelas

Diseases related to Erysipelas via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 elephantiasis 30.3 ELANE ELN
2 brucellosis 30.2 MEFV TNF
3 familial mediterranean fever 29.8 MEFV TNF
4 vasculitis 29.8 ELANE MEFV TNF
5 erysipeloid 29.7 LYZ MEFV
6 impetigo 29.5 CALCA ELANE PI3
7 pneumonia 29.5 ELANE PIK3C2A TNF
8 endocarditis 29.4 PIK3C2A TNF
9 arthus reaction 10.4 ELANE TNF
10 tympanosclerosis 10.4 CALCA TNF
11 pustulosis palmaris et plantaris 10.4 ELANE TNF
12 cellulitis 10.4
13 lichen sclerosus 10.4 ELN TNF
14 aseptic meningitis 10.4 CALCA TNF
15 cerebral aneurysms 10.4 ELANE ELN
16 mid-dermal elastolysis 10.4 ELANE ELN
17 irritant dermatitis 10.3 PI3 TNF
18 pasteurellosis 10.3 ELANE PI3
19 complex regional pain syndrome 10.3 CALCA TNF
20 impetigo herpetiformis 10.3 ELANE PI3
21 engraftment syndrome 10.3 CALCA PI3
22 headache 10.3 CALCA TNF
23 leukocyte disease 10.3 ELANE TNF
24 alpha-1-antitrypsin deficiency 10.3 ELANE ELN
25 crimean-congo hemorrhagic fever 10.3 PIK3C2A TNF
26 compartment syndrome 10.3 PIK3C2A TNF
27 status asthmaticus 10.3 ELANE PIK3C2A
28 chorioamnionitis 10.3 ELANE TNF
29 systemic onset juvenile idiopathic arthritis 10.2 MEFV TNF
30 autoinflammation, panniculitis, and dermatosis syndrome 10.2 MEFV TNF
31 extrinsic cardiomyopathy 10.2 PIK3C2A TNF
32 relapsing fever 10.2 MEFV TNF
33 legionellosis 10.2 PIK3C2A TNF
34 pulmonary emphysema 10.2 ELANE ELN
35 leptospirosis 10.2 PIK3C2A TNF
36 arthritis 10.2
37 blau syndrome 10.2 MEFV TNF
38 netherton syndrome 10.2 ELANE PI3
39 pyoderma gangrenosum 10.2 MEFV TNF
40 pyoderma 10.2 MEFV TNF
41 adult-onset still's disease 10.2 MEFV TNF
42 aphthous stomatitis 10.2 MEFV TNF
43 palindromic rheumatism 10.2 MEFV TNF
44 pulmonary disease, chronic obstructive 10.1 ELANE ELN TNF
45 adult respiratory distress syndrome 10.1 ELANE ELN TNF
46 pleurisy 10.1 MEFV TNF
47 wegener granulomatosis 10.1 ELANE ELN TNF
48 pericarditis 10.1 MEFV TNF
49 pustular psoriasis 10.1 ELANE PI3 TNF
50 farmer's lung 10.1 ELANE PI3 TNF

Graphical network of the top 20 diseases related to Erysipelas:



Diseases related to Erysipelas

Symptoms & Phenotypes for Erysipelas

UMLS symptoms related to Erysipelas:


exanthema

Drugs & Therapeutics for Erysipelas

Drugs for Erysipelas (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
2
Daptomycin Approved, Investigational Phase 4,Phase 2 103060-53-3 16129629
3
Vancomycin Approved Phase 4 1404-90-6 14969 441141
4
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
5 Anti-Bacterial Agents Phase 4,Phase 2
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4,Phase 2
8 penicillins Phase 4
9 Antitubercular Agents Phase 4
10 Floxacillin Phase 4
11
Menthol Approved Phase 3 2216-51-5 16666
12 Torezolid Phase 2
13 Torezolid phosphate Phase 2
14
Linezolid Approved, Investigational 165800-03-3 441401
15
Dimenhydrinate Approved 523-87-5 441281
16 methicillin
17 Dermatologic Agents

Interventional clinical trials:

(show all 13)

# Name Status NCT ID Phase Drugs
1 RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg Completed NCT00552799 Phase 4 Penicillin VK
2 Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelas Completed NCT00295178 Phase 4 Daptomycin;Vancomycin
3 Short Course of Amoxicillin for Erysipelas Terminated NCT01059123 Phase 4 Amoxicillin;Amoxicillin
4 Duration of ANtibiotic Therapy for CEllulitis Terminated NCT02032654 Phase 4 Flucloxacillin;Placebo (for flucloxacillin)
5 Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema Recruiting NCT03210311 Phase 3
6 A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study Completed NCT01519778 Phase 2 TR701 FA
7 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
8 Efficacy and Safety Study of Brilacidin to Treat Serious Skin Infections Completed NCT02052388 Phase 2 Daptomycin;Brilacidin
9 Fat Grafting Used for the Treatment of Breast Cancer Related Lymphedema in China Recruiting NCT02981485 Phase 2
10 The Use of Oral Steroids in the Treatment of Cellulitis Withdrawn NCT00893048 Phase 2 Prednisone;Placebo Oral Tablet
11 Sivextro in Acute Bacterial Skin and Skin Structure Infection (ABSSSI) in Hospitalized Patients. A Global Observational Study Recruiting NCT02991131 Tedizolid (Sivextro, BAY 11-70438);Linezolid
12 Effectiveness of Fluoroscopy-guided MLD for Treatment of BCRL Recruiting NCT02609724
13 Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo Active, not recruiting NCT02902822

Search NIH Clinical Center for Erysipelas

Cochrane evidence based reviews: erysipelas

Genetic Tests for Erysipelas

Genetic tests related to Erysipelas:

# Genetic test Affiliating Genes
1 Erysipelas 28

Anatomical Context for Erysipelas

MalaCards organs/tissues related to Erysipelas:

38
Skin, Testes, Colon, Monocytes, B Cells, Pituitary, Neutrophil

Publications for Erysipelas

Articles related to Erysipelas:

(show top 50) (show all 541)
# Title Authors Year
1
Pitfall of modern genetics: recurrent erysipelas masquerading as autoinflammatory disease. ( 28741584 )
2017
2
Bilateral Milian's Ear Sign of Erysipelas. ( 28794379 )
2017
3
Clonal Lineages of Erysipelothrix rhusiopathiae Responsible for Acute Swine Erysipelas in Japan Identified by Using Genome-Wide Single-Nucleotide Polymorphism Analysis. ( 28314730 )
2017
4
Pathogenic characterization of Erysipelothrix rhusiopathiae Met-203 type SpaA strains from chronic and subacute swine erysipelas in Japan. ( 27773881 )
2017
5
Benzathine penicillin G once-every-3-week prophylaxis for recurrent erysipelas a retrospective study of 132 patients. ( 28489486 )
2017
6
The Myth of Erysipelas-Fire, Water, and Blood. ( 28114522 )
2017
7
Interventions for the prevention of recurrent erysipelas and cellulitis. ( 28631307 )
2017
8
Risk factors associated with local complications of erysipelas: a retrospective study of 152 cases. ( 28451043 )
2017
9
Single nucleotide polymorphism genotyping of Erysipelothrix rhusiopathiae isolates from pigs affected with chronic erysipelas in Japan. ( 28250289 )
2017
10
Elephantiasis nostras verrucosa secondary to recurrent erysipelas. ( 28838924 )
2017
11
Identifying priority areas for research into the diagnosis, treatment and prevention of cellulitis (erysipelas): results of a James Lind Alliance Priority Setting Partnership. ( 28477399 )
2017
12
Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients. ( 28512644 )
2017
13
Meta-analysis of randomised trials comparing a penicillin or cephalosporin with a macrolide or lincosamide in the treatment of cellulitis or erysipelas. ( 27085865 )
2016
14
Pseudo-erysipelas: A new atypical cutaneous manifestation of parvovirus B19 primary infection. ( 26791960 )
2016
15
Low sensitivity of needle aspiration cultures in patients with cellulitis/erysipelas. ( 27652151 )
2016
16
The effects of amoxicillin, ceftiofur, doxycycline, tiamulin and tulathromycin on swine humoral immune response induced by erysipelas vaccination. ( 27072375 )
2016
17
Complete genome sequence of Erysipelothrix rhusiopathiae strain GXBY-1 isolated from acute swine erysipelas outbreaks in south China. ( 27222802 )
2016
18
How to treat a fulminant erysipelas and sepsis caused by Myroides odoratimimus: case report and literature review. ( 27765000 )
2016
19
Clinical and epidemiological assessment of patients hospitalized for primary and recurrent erysipelas ( 28221013 )
2016
20
Familial Mediterranean fever patients may have unmet need for treatment of erysipelas-like erythema. ( 27782864 )
2016
21
A Fatal Case of "Bullous Erysipelas-like" Pseudomonas Vasculitis. ( 26955132 )
2016
22
Impetigo, Erysipelas and Cellulitis ( 26866211 )
2016
23
Complicated Skin and Skin Structure Infection After Erysipelas: Urgent Need for Antibiosis and Surgery. ( 26933116 )
2016
24
Dermatologic Diseases in 8 of the Cantigas of Holy Mary of Alfonso X the Learned - Part 2: Genital Mutilation, Scrofuloderma, Scabies, Erysipelas, and the Ailments of the King. ( 27156179 )
2016
25
High Incidence of Erysipelas After Surgical Treatment for Vulvar Carcinoma: An Observational Study. ( 26807636 )
2016
26
Endogenous endophthalmitis secondary to erysipelas. ( 26123459 )
2015
27
Use of procalcitonin, C-reactive protein and white blood cell count to distinguish between lower limb erysipelas and deep vein thrombosis in the emergency department: A prospective observational study. ( 25982244 )
2015
28
Characterization of <i>Erysipelothrix rhusiopathiae</i> strains isolated from acute swine erysipelas outbreaks in Eastern China. ( 25649849 )
2015
29
Cellulitis and erysipelas: prevention. ( 26580894 )
2015
30
Risk factors associated with a reduced response in the treatment of erysipelas. ( 25706926 )
2015
31
Erysipelas in turkeys, sheep and pigs. ( 25792678 )
2015
32
Safety and efficacy of a new octavalent combined Erysipelas, Parvo and Leptospira vaccine in gilts against Leptospira interrogans serovar Pomona associated disease and foetal death. ( 26100922 )
2015
33
Synergic effect of erysipelas on aggression to the lymphatic system in patients submitted to the excision of a saphenous vein. ( 26344512 )
2015
34
Erysipelas Outbreaks in Flocks of Geese in Poland--Biochemical and Genetic Analyses of the Isolates. ( 26478164 )
2015
35
Pseudo-kaposi sarcoma (acroangiodermatitis): occurring after bullous erysipelas. ( 26295854 )
2015
36
Erysipelas, a large retrospective study of aetiology and clinical presentation. ( 26424182 )
2015
37
Risk factors associated with abscess formation among patient with leg erysipelas (cellulitis) in sub-Saharan Africa: a multicenter study. ( 26666633 )
2015
38
Diagnosis and management of cellulitis and erysipelas. ( 26255928 )
2015
39
Erysipelas in a free-range layer flock with conjunctival oedema as an unusual clinical sign. ( 24881267 )
2014
40
Microorganisms of the toe web and their importance for erysipelas of the leg. ( 24961650 )
2014
41
Erysipelas and myocarditis. ( 24502912 )
2014
42
Penicillin as a therapeutic option in the treatment of in-hospital erysipelas. ( 24566577 )
2014
43
Erysipelas as a superinfection of an oral lymphangioma. ( 24793202 )
2014
44
Recurrent erysipelas--risk factors and clinical presentation. ( 24884840 )
2014
45
Complete genome assembly and characterization of an outbreak strain of the causative agent of swine erysipelas--Erysipelothrix rhusiopathiae SY1027. ( 24993343 )
2014
46
Erysipelothrix rhusiopathiae contamination in the poultry house environment during erysipelas outbreaks in organic laying hen flocks. ( 24661145 )
2014
47
Unusual presentation of chikungunya virus infection with concomintant erysipelas in a returning traveler from the Caribbean: a case report. ( 25734165 )
2014
48
Pretibial erysipelas-like erythema as the primary manifestation of renal cell carcinoma, a paraneoplastic manifestation. ( 24556357 )
2014
49
Erysipelas-like Erythema in a Patient with Familial Mediterranean Fever. ( 25362709 )
2014
50
An unusual erysipelas-like presentation. ( 24456958 )
2014

Variations for Erysipelas

Expression for Erysipelas

Search GEO for disease gene expression data for Erysipelas.

Pathways for Erysipelas

GO Terms for Erysipelas

Cellular components related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 CALCA ELANE GUSB LYZ TNF
2 specific granule lumen GO:0035580 9.26 ELANE LYZ
3 extracellular region GO:0005576 9.17 CALCA ELANE ELN GUSB LYZ PI3
4 azurophil granule lumen GO:0035578 9.13 ELANE GUSB LYZ

Biological processes related to Erysipelas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.54 ELANE LYZ TNF
2 inflammatory response GO:0006954 9.46 CALCA LYZ MEFV TNF
3 positive regulation of MAP kinase activity GO:0043406 9.43 ELANE TNF
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.4 ELANE TNF
5 positive regulation of interleukin-8 production GO:0032757 9.32 CALCA TNF
6 negative regulation of growth of symbiont in host GO:0044130 9.26 ELANE TNF
7 positive regulation of interleukin-8 biosynthetic process GO:0045416 8.96 ELANE TNF
8 antimicrobial humoral response GO:0019730 8.8 ELANE LYZ PI3

Sources for Erysipelas

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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