MCID: ERY017
MIFTS: 41

Erythema Elevatum Diutinum malady

Skin, Bone categories

Summaries for Erythema Elevatum Diutinum

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Erythema elevatum diutinum is a rare type of chronic cutaneous vasculitis characterized by red, purple, brown or yellow papules, plaques (thick, red patches of skin), or nodules.these lesions are located mainly on the knees, elbows, hands, feet, face, genitals and buttocks. although it is a chronic condition, most cases respond well to treatment with dapsone. the cause of this condition remains unknown.  last updated: 4/13/2010

MalaCards: Erythema Elevatum Diutinum is related to vasculitis and arthritis, and has symptoms including cutaneous rash, erythema/erythematous lesions/erythroderma/polymorphous erythema and follicular/erythematous/edematous papules/milium. An important gene associated with Erythema Elevatum Diutinum is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Malaria and Rheumatoid arthritis. The compounds reticulin and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include liver, thyroid and breast, and related mouse phenotype hematopoietic system.

Wikipedia:64 Erythema elevatum diutinum is a form of vasculitis. more...

Aliases & Classifications for Erythema Elevatum Diutinum

Sources:
43NIH Rare Diseases, 49Orphanet, 61UMLS, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin, Bone


Characteristics (Orphanet epidemiological data):

49
erythema elevatum diutinum:
Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

erythema elevatum diutinum 43 49 61


External Ids:

UMLS via Orphanet62 C0263398
MESH via Orphanet36 C535509
ICD10 via Orphanet26 L95.1
SNOMED-CT via Orphanet58 254757003, 58872001
ICD1025 L95.1

Related Diseases for Erythema Elevatum Diutinum

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Erythema Elevatum Diutinum:



Diseases related to erythema elevatum diutinum

Clinical Features for Erythema Elevatum Diutinum

Sources:
49Orphanet
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Symptoms:

49 (show all 9)
  • cutaneous rash
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • follicular/erythematous/edematous papules/milium
  • vascularitis/vasculitides/arteritis
  • articular/joint pain/arthralgia
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • monoclonal immunoglobulins/gammapathy/dysglobulinemia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • myalgia/muscular pain

Drugs & Therapeutics for Erythema Elevatum Diutinum

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Erythema Elevatum Diutinum

Anatomical Context for Erythema Elevatum Diutinum

Sources:
33MalaCards
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MalaCards organs/tissues related to Erythema Elevatum Diutinum:

33
Liver, Thyroid, Breast, Skin, B cells

Animal Models for Erythema Elevatum Diutinum or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Erythema Elevatum Diutinum:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.5PECAM1, IL8, CD79A, F13A1, ITGB2

Publications for Erythema Elevatum Diutinum

Sources:
51PubMed
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Articles related to Erythema Elevatum Diutinum:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Erythema elevatum diutinum. (23442466)
2013
2
Novel use of topical dapsone 5% gel for erythema elevatum diutinum: safer and effective. (23652900)
2013
3
Erythema elevatum diutinum with oral ulceration. (22284024)
2012
4
Erythema elevatum diutinum: an "idiopathic" case. (21810392)
2011
5
A case of extensive erosive and bullous erythema elevatum diutinum in a patient diagnosed with human immunodeficiency virus (HIV). (21781074)
2011
6
Progressive keratolysis with pseudopterygium associated with erythema elevatum diutinum. (21211842)
2011
7
Erythema elevatum diutinum associated with scleritis. (23130212)
2011
8
Erythema elevatum diutinum associated with dermatomyositis. (21496713)
2011
9
Acceleration of pulmonary interstitial fibrosis in a patient with myeloperoxidase-antineutrophil cytoplasmic antibody-positive erythema elevatum diutinum. (21839335)
2011
10
Erythema elevatum diutinum presenting with a giant annular pattern. (19261019)
2009
11
An atypical presentation of erythema elevatum diutinum involving palms and soles. (19126056)
2009
12
Photoclinic. Erythema elevatum diutinum. (18759532)
2008
13
The development of erythema elevatum diutinum in a patient with juvenile idiopathic arthritis under treatment with abatacept. (17932616)
2008
14
Erythema elevatum diutinum associated with lupus panniculitis in a patient with discoid lesions of chronic cutaneous lupus erythematosus. (15034527)
2004
15
Late-stage nodular erythema elevatum diutinum. (14512939)
2003
16
A case of myasthenia gravis accompanied by erythema elevatum diutinum and rheumatoid arthritis. (11437173)
2001
17
Erythema elevatum diutinum, a clinical entity to be considered in patients infected with HIV-1. (11722464)
2001
18
Relapsing polychondritis and erythema elevatum diutinum: an unusual association refractory to dapsone. (11296973)
2001
19
Erythema elevatum diutinum. (10856661)
2000
20
Erythema elevatum diutinum--evidence for disease-dependent leucocyte alterations and response to dapsone. (10951156)
2000
21
Erythema elevatum diutinum/Sweet's syndrome overlap with gastrointestinal and oral involvement. (10583147)
1999
22
Erythema elevatum diutinum complicated by rheumatoid arthritis. (10458086)
1999
23
Erythema elevatum diutinum in an HIV+ hemophilic patient. (10608257)
1999
24
Nodular erythema elevatum diutinum in an HIV-1 infected woman: response to dapsone and antiretroviral therapy. (9640395)
1998
25
Peripheral ulcerative keratitis associated with erythema elevatum diutinum and a positive rheumatoid factor: a report of three cases. (9666842)
1998
26
Nodular erythema elevatum diutinum mimicking cutaneous neoplasms. (9253631)
1997
27
Erythema elevatum diutinum associated with pulmonary infiltrates. (9390354)
1997
28
Localized chronic fibrosing vasculitis of the skin: an inflammatory reaction that occurs in settings other than erythema elevatum diutinum and granuloma faciale. (9199648)
1997
29
Pyoderma gangrenosum, erythema elevatum diutinum and IgA monoclonal gammopathy. (7763217)
1995
30
Simultaneous occurrence of two rare cutaneous markers of poor prognosis in myelodysplastic syndrome: erythema elevatum diutinum and specific lesions. (8043402)
1994
31
Ulcerated nodules on the elbows, fingers, and knees. Erythema elevatum diutinum (EED). (8352608)
1993
32
Ultrastructural study of chronic lesions of erythema elevatum diutinum: "extracellular cholesterosis" is a misnomer. (8340516)
1993
33
Nodular lesions of erythema elevatum diutinum in patients infected with the human immunodeficiency virus. (8496454)
1993
34
Erythema elevatum diutinum: a clinical and histopathologic study of 13 patients. (1732334)
1992
35
Erythema elevatum diutinum mimicking porphyria cutanea tarda. (1993150)
1991
36
Erythema elevatum diutinum--a solitary lesion in a patient with rheumatoid arthritis. (2225548)
1990
37
Erythema elevatum diutinum--a case successfully treated with colchicine. (2605811)
1989
38
Erythema elevatum diutinum: unusual eruption during antituberculosis chemotherapy. (3391724)
1988
39
Erythema elevatum diutinum--an unusual case. (4092361)
1985
40
Unique aspects of a lesion of erythema elevatum diutinum. (6507812)
1984
41
Erythema elevatum diutinum. (646410)
1978
42
Erythema elevatum diutinum and IgA myeloma: an interesting association. (902003)
1977
43
Erythema elevatum diutinum. (4694177)
1973
44
Erythema elevatum diutinum. (4296609)
1968
45
Erythema elevatum diutinum. (5741772)
1968
46
Erythema elevatum diutinum. Presentation of a case and evaluation of laboratory and immunological status. (4166920)
1967
47
Erythema elevatum diutinum; a case report. (12981693)
1952
48
Eosinophilic granuloma of the skin; its relation to erythema elevatum diutinum and eosinophilic granuloma of the bone; report of a case. (20286475)
1947
49
Erythema Elevatum Diutinum. (19988984)
1932
50
Erythema Elevatum Diutinum (Crocker). (19984955)
1926

Genetic Variations for Erythema Elevatum Diutinum

Expression for genes affiliated with Erythema Elevatum Diutinum

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Erythema Elevatum Diutinum

Search GEO for disease gene expression data for Erythema Elevatum Diutinum.

Pathways for genes affiliated with Erythema Elevatum Diutinum

Sources:
30KEGG, 54Reactome, 12EMD Millipore, 52QIAGEN
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Compounds for genes affiliated with Erythema Elevatum Diutinum

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Erythema Elevatum Diutinum according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1reticulin4510.3CD79A
2pentoxifylline45 1111.0ITGB2
35 aminosalicylic acid459.8IL8, PECAM1
4azithromycin45 1110.8CD79A, IL8
5polyurethane459.8ITGB2, PECAM1
6clarithromycin45 1110.8CD79A, IL8
7rantes459.8PECAM1, ITGB2
8slex459.7ITGB2, PECAM1
9polycarbonate459.7ITGB2, IL8
10sulfasalazine45 29 50 1112.7IL8, CD79A
11salmeterol45 50 29 1112.7ITGB2, IL8
12piroxicam45 1110.7CD79A, ITGB2
13silicone459.7CD79A, ITGB2
14methacholine45 1110.7CD79A, IL8
15polymyxin b459.7IL8, ITGB2
16cellulose acetate459.6CD79A, ITGB2
17okt3459.6ITGB2, CD79A
18con a459.6CD79A, ITGB2
19calyculin a45 60 1111.6ITGB2, PECAM1
20n-formylmethionyl-leucylphenylalanine459.6IL8, ITGB2
21ivig459.5ITGB2, CD79A
22erythromycin45 50 2 1112.5ITGB2, IL8
23fluconazole45 1110.5CD79A, F13A1
24neopterin459.3IL8, CD79A
25h2o2459.3PECAM1, CD79A, ITGB2
26cytochalasin d45 6010.3ITGB2, IL8, PECAM1
27salbutamol45 50 29 11 2413.2IL8, CD79A, ITGB2
28hyaluronic acid45 2410.2IL8, CD79A, ITGB2
29hematoxylin459.2F13A1, PECAM1
30kininogen459.1F13A1, ITGB2
31lactate459.1IL8, CD79A, ITGB2
32aspirin45 50 29 2412.1PECAM1, CD79A, F13A1
33nocodazole45 1110.0CD79A, ITGB2
34dithiothreitol459.0F13A1, ITGB2
35paraffin458.9F13A1, CD79A, PECAM1
36histamine45 29 2410.8ITGB2, CD79A, IL8, PECAM1
37cyclosporin a45 29 6010.8PECAM1, IL8, CD79A, ITGB2
38cysteine458.7ITGB2, CD79A, IL8, PECAM1
39fibrinogen458.5ITGB2, F13A1, CD79A, PECAM1
40heparin45 29 11 2411.0PECAM1, IL8, CD79A, F13A1, ITGB2
41vegf458.0ITGB2, F13A1, CD79A, IL8, PECAM1

GO Terms for genes affiliated with Erythema Elevatum Diutinum

Sources:
16Gene Ontology
See all sources

Biological processes related to Erythema Elevatum Diutinum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neutrophil chemotaxisGO:0305939.2IL8, ITGB2
2platelet degranulationGO:0025769.2PECAM1, F13A1
3blood coagulationGO:0075968.3PECAM1, F13A1, ITGB2

Products for genes affiliated with Erythema Elevatum Diutinum

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Erythema Elevatum Diutinum

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet