MCID: ERY017
MIFTS: 50

Erythema Elevatum Diutinum malady

Rare diseases, Skin diseases, Cardiovascular diseases, Bone diseases categories
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Summaries for Erythema Elevatum Diutinum

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NIH Rare Diseases:42 Erythema elevatum diutinum is a rare type of chronic cutaneous vasculitis characterized by red, purple, brown or yellow papules, plaques (thick, red patches of skin), or nodules.these lesions are located mainly on the knees, elbows, hands, feet, face, genitals and buttocks. although it is a chronic condition, most cases respond well to treatment with dapsone. the cause of this condition remains unknown.  last updated: 4/13/2010

MalaCards based summary: Erythema Elevatum Diutinum is related to vasculitis and arthritis, and has symptoms including cutaneous rash, erythema/erythematous lesions/erythroderma/polymorphous erythema and follicular/erythematous/edematous papules/milium. An important gene associated with Erythema Elevatum Diutinum is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Lymphocyte Signaling and Cell adhesion molecules (CAMs). The compounds 5 aminosalicylic acid and azithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and neutrophil, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:65 Erythema elevatum diutinum is a form of vasculitis. more...

Aliases & Classifications for Erythema Elevatum Diutinum

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Sources:
42NIH Rare Diseases, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Erythema Elevatum Diutinum, Aliases & Descriptions:

Name: Erythema Elevatum Diutinum 42 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Cardiovascular diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
erythema elevatum diutinum:
Age of onset: Variable; Age of death: Normal


External Ids:

MESH via Orphanet35 C535509
ICD10 via Orphanet26 L95.1
UMLS via Orphanet63 C0263398
ICD1025 L95.1

Related Diseases for Erythema Elevatum Diutinum

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Graphical network of the top 20 diseases related to Erythema Elevatum Diutinum:



Diseases related to erythema elevatum diutinum

Symptoms for Erythema Elevatum Diutinum

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Symptoms:

48 (show all 9)
  • cutaneous rash
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • follicular/erythematous/edematous papules/milium
  • vascularitis/vasculitides/arteritis
  • articular/joint pain/arthralgia
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • monoclonal immunoglobulins/gammapathy/dysglobulinemia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • myalgia/muscular pain

HPO human phenotypes related to Erythema Elevatum Diutinum:

(show all 6)
id Description Frequency HPO Source Accession
1 skin rash hallmark (90%) HP:0000988
2 vasculitis hallmark (90%) HP:0002633
3 arthralgia hallmark (90%) HP:0002829
4 abnormal blistering of the skin typical (50%) HP:0008066
5 abnormal immunoglobulin level typical (50%) HP:0010701
6 myalgia occasional (7.5%) HP:0003326

Drugs & Therapeutics for Erythema Elevatum Diutinum

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Drug clinical trials:

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Genetic Tests for Erythema Elevatum Diutinum

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Anatomical Context for Erythema Elevatum Diutinum

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MalaCards organs/tissues related to Erythema Elevatum Diutinum:

32
Skin, Bone, Neutrophil, Liver, Thyroid, Breast, B cells

Animal Models for Erythema Elevatum Diutinum or affiliated genes

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MGI Mouse Phenotypes related to Erythema Elevatum Diutinum:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4CD79A, IL8, ITGB2, PECAM1
2MP:00053977.2CD79A, IL8, ITGB2, F13A1, PECAM1

Publications for Erythema Elevatum Diutinum

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Articles related to Erythema Elevatum Diutinum:

(show top 50)    (show all 169)
idTitleAuthorsYear
1
Case of Erythema Elevatum Diutinum Associated With IgA Paraproteinemia Successfully Controlled With Thalidomide and Plasma Exchange. (25257541)
2014
2
Erythema elevatum diutinum. (23487831)
2013
3
Atypical erythema elevatum diutinum or extrafacial granuloma faciale? (23253514)
2013
4
Successful combination therapy with dapsone and cyclosporine for erythema elevatum diutinum with unusual appearance. (22132683)
2012
5
A case of erythema elevatum diutinum associated with peripheral ulcerative keratitis. (22309340)
2012
6
Erythema elevatum diutinum: an "idiopathic" case. (21810392)
2011
7
Erythema elevatum diutinum mimicking a vesiculobullous disease. (22126877)
2011
8
A case of extensive erosive and bullous erythema elevatum diutinum in a patient diagnosed with human immunodeficiency virus (HIV). (21781074)
2011
9
Is IgA antineutrophil cytoplasmic antibody a marker for patients with erythema elevatum diutinum? A further three cases demonstrating this association. (21143463)
2011
10
Erythema elevatum diutinum as a paraneoplastic syndrome in a patient with pulmonary lymphoepithelioma-like carcinoma. (18571759)
2009
11
Photoclinic. Erythema elevatum diutinum. (18759532)
2008
12
The development of erythema elevatum diutinum in a patient with juvenile idiopathic arthritis under treatment with abatacept. (17932616)
2008
13
Infantile erythema elevatum diutinum: report of a vesiculo-bullous case. (17229612)
2006
14
Erythema elevatum diutinum: clinical, histopathologic, and immunohistochemical characteristics of six patients. (16148408)
2005
15
Erythema elevatum diutinum in the setting of connective tissue disease and chronic bacterial infection. (16357711)
2005
16
Neutrophilic dermatosis of the dorsal hands: a variant of erythema elevatum diutinum? (12533183)
2003
17
Erythema elevatum diutinum. (14594610)
2003
18
Erythema elevatum diutinum in an HIV-positive patient. (12884465)
2003
19
A case of myasthenia gravis accompanied by erythema elevatum diutinum and rheumatoid arthritis. (11437173)
2001
20
Erythema elevatum diutinum/Sweet's syndrome overlap with gastrointestinal and oral involvement. (10583147)
1999
21
Erythema elevatum diutinum in a patient with human herpesvirus 6 infection. (10086876)
1999
22
Erythema elevatum diutinum complicated by rheumatoid arthritis. (10458086)
1999
23
Erythema elevatum diutinum and HIV infection: a report of five cases. (10468812)
1999
24
Erythema elevatum diutinum and AIDS: are they related? (9580188)
1997
25
Nodular erythema elevatum diutinum mimicking cutaneous neoplasms. (9253631)
1997
26
Erythema elevatum diutinum: a clinicopathological study of eight cases. (9185905)
1997
27
Erythema elevatum diutinum associated with pulmonary infiltrates. (9390354)
1997
28
Unusual erythema elevatum diutinum with fibrohistiocytic proliferation. (8763440)
1996
29
Erythema elevatum diutinum. (8002161)
1994
30
Simultaneous occurrence of two rare cutaneous markers of poor prognosis in myelodysplastic syndrome: erythema elevatum diutinum and specific lesions. (8043402)
1994
31
Erythema elevatum diutinum and chronic lymphocytic leukemia. (8050158)
1994
32
Ulcerated nodules on the elbows, fingers, and knees. Erythema elevatum diutinum (EED). (8352608)
1993
33
Ultrastructural study of chronic lesions of erythema elevatum diutinum: "extracellular cholesterosis" is a misnomer. (8340516)
1993
34
Pyoderma gangrenosum in association with erythema elevatum diutinum: report of two cases. (1572226)
1992
35
Erythema elevatum diutinum: a clinicopathological study. (1516248)
1992
36
Erythema elevatum diutinum--a case successfully treated with colchicine. (2605811)
1989
37
Erythema elevatum diutinum and pre-AIDS. (2426910)
1986
38
The evolution of lesions in erythema elevatum diutinum. (3777377)
1986
39
Erythema elevatum diutinum--a report of two unusual patients. (6641012)
1983
40
Erythema elevatum diutinum treated with niacinamide and tetracycline. (6445715)
1980
41
Erythema elevatum diutinum and IgA myeloma: an interesting association. (902003)
1977
42
ERYTHEMA ELEVATUM DIUTINUM? (14164982)
1964
43
ERYTHEMA ELEVATUM DIUTINUM. (14068149)
1963
44
Erythema elevatum diutinum. A type of allergic vasulitis. (14463051)
1962
45
Erythema elevatum diutinum; report of a case. (13616718)
1959
46
Erythema elevatum diutinum. (14363564)
1955
47
Erythema multiforme perstans (erythema elevatum diutinum). (15440777)
1950
48
Status of erythema elevatum diutinum. (18912481)
1948
49
Eosinophilic granuloma of the skin; its relation to erythema elevatum diutinum and eosinophilic granuloma of the bone; report of a case. (20286475)
1947
50
Erythema Elevatum Diutinum (Case Previously Shown). (19985753)
1927

Variations for Erythema Elevatum Diutinum

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Expression for genes affiliated with Erythema Elevatum Diutinum

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Expression patterns in normal tissues for genes affiliated with Erythema Elevatum Diutinum

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Pathways for genes affiliated with Erythema Elevatum Diutinum

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Compounds for genes affiliated with Erythema Elevatum Diutinum

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Compounds related to Erythema Elevatum Diutinum according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
15 aminosalicylic acid449.9PECAM1, IL8
2azithromycin44 1110.9IL8, CD79A
3polyurethane449.8ITGB2, PECAM1
4clarithromycin44 1110.8IL8, CD79A
5sulfasalazine28 44 50 1112.8CD79A, IL8
6slex449.8ITGB2, PECAM1
7methacholine44 50 1111.8CD79A, IL8
8polycarbonate449.8ITGB2, IL8
9salmeterol44 50 28 1112.7IL8, ITGB2
10piroxicam44 1110.7CD79A, ITGB2
11silicone449.7CD79A, ITGB2
12polymyxin b449.7IL8, ITGB2
13cellulose acetate449.7CD79A, ITGB2
14okt3449.7CD79A, ITGB2
15calyculin a44 61 1111.7PECAM1, ITGB2
16con a449.7CD79A, ITGB2
17rolipram44 61 2811.7IL8, ITGB2
18neopterin449.6CD79A, IL8
19n-formylmethionyl-leucylphenylalanine449.6IL8, ITGB2
20ivig449.6ITGB2, CD79A
21erythromycin44 2 50 1112.6ITGB2, IL8
22pentoxifylline44 1110.6IL8, ITGB2
23reticulin449.5CD79A, F13A1
24fluconazole44 1110.5F13A1, CD79A
25nocodazole44 1110.5ITGB2, CD79A
26hematoxylin449.4PECAM1, F13A1
27leukotriene b444 61 2411.4IL8, ITGB2
28prednisolone44 28 1111.3CD79A, ITGB2
29cytochalasin d44 6110.3PECAM1, ITGB2, IL8
30rantes449.3PECAM1, ITGB2, IL8
31kininogen449.3ITGB2, F13A1
32salbutamol44 50 28 24 1113.3CD79A, IL8, ITGB2
33hyaluronic acid44 2410.2CD79A, IL8, ITGB2
34sodium dodecylsulfate449.2ITGB2, CD79A
35superoxide44 2410.2IL8, ITGB2, PECAM1
36cycloheximide449.2PECAM1, ITGB2, IL8
37lactate449.2ITGB2, IL8, CD79A
38dithiothreitol449.1F13A1, ITGB2
39aspirin44 50 28 2412.1CD79A, F13A1, PECAM1
40paraffin449.0PECAM1, F13A1, CD79A
41dexamethasone44 50 28 1112.0CD79A, IL8, ITGB2
42nitric oxide44 24 1110.9IL8, ITGB2, PECAM1
43histamine44 28 2410.8CD79A, IL8, ITGB2, PECAM1
44cyclosporin a44 28 6110.8PECAM1, ITGB2, IL8, CD79A
45h2o2448.8CD79A, IL8, ITGB2, PECAM1
46cysteine448.8CD79A, IL8, ITGB2, PECAM1
47fibrinogen448.5PECAM1, F13A1, ITGB2, CD79A
48adp44 28 2410.3ITGB2, F13A1, PECAM1
49heparin44 28 24 1111.0CD79A, IL8, ITGB2, F13A1, PECAM1
50vegf448.0PECAM1, F13A1, ITGB2, IL8, CD79A

GO Terms for genes affiliated with Erythema Elevatum Diutinum

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Biological processes related to Erythema Elevatum Diutinum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1leukocyte migrationGO:0509009.4ITGB2, PECAM1
2neutrophil chemotaxisGO:0305939.3IL8, ITGB2
3platelet degranulationGO:0025768.9F13A1, PECAM1
4blood coagulationGO:0075968.5ITGB2, F13A1, PECAM1

Products for genes affiliated with Erythema Elevatum Diutinum

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Sources for Erythema Elevatum Diutinum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet