MCID: ERY017
MIFTS: 49

Erythema Elevatum Diutinum malady

Rare diseases, Skin diseases, Bone diseases categories

Summaries for Erythema Elevatum Diutinum

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Erythema elevatum diutinum is a rare type of chronic cutaneous vasculitis characterized by red, purple, brown or yellow papules, plaques (thick, red patches of skin), or nodules.these lesions are located mainly on the knees, elbows, hands, feet, face, genitals and buttocks. although it is a chronic condition, most cases respond well to treatment with dapsone. the cause of this condition remains unknown.  last updated: 4/13/2010

MalaCards: Erythema Elevatum Diutinum is related to vasculitis and arthritis, and has symptoms including myalgia/muscular pain, subcutaneous nodules/lipomas/tumefaction/swelling and monoclonal immunoglobulins/gammapathy/dysglobulinemia. An important gene associated with Erythema Elevatum Diutinum is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Lymphocyte Signaling and Cell adhesion molecules (CAMs). The compounds 5 aminosalicylic acid and azithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and b cells, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:66 Erythema elevatum diutinum is a form of vasculitis. more...

Aliases & Classifications for Erythema Elevatum Diutinum

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44NIH Rare Diseases, 50Orphanet, 63UMLS, 64UMLS via Orphanet, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

50
erythema elevatum diutinum:
Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

erythema elevatum diutinum 44 50 63


External Ids:

UMLS via Orphanet64 C0263398
MESH via Orphanet37 C535509
ICD10 via Orphanet27 L95.1
SNOMED-CT via Orphanet60 254757003, 58872001
ICD1026 L95.1

Related Diseases for Erythema Elevatum Diutinum

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Erythema Elevatum Diutinum:



Diseases related to erythema elevatum diutinum

Symptoms for Erythema Elevatum Diutinum

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50Orphanet
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Symptoms:

50 (show all 9)
  • myalgia/muscular pain
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • monoclonal immunoglobulins/gammapathy/dysglobulinemia
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • articular/joint pain/arthralgia
  • vascularitis/vasculitides/arteritis
  • follicular/erythematous/edematous papules/milium
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • cutaneous rash

Drugs & Therapeutics for Erythema Elevatum Diutinum

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Genetic Tests for Erythema Elevatum Diutinum

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Anatomical Context for Erythema Elevatum Diutinum

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34MalaCards
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MalaCards organs/tissues related to Erythema Elevatum Diutinum:

34
Skin, Bone, B cells, Breast, Thyroid, Liver

Animal Models for Erythema Elevatum Diutinum or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Erythema Elevatum Diutinum:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4CD79A, IL8, ITGB2, PECAM1
2MP:00053977.2CD79A, IL8, ITGB2, F13A1, PECAM1

Publications for Erythema Elevatum Diutinum

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53PubMed
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Articles related to Erythema Elevatum Diutinum:

(show top 50)    (show all 165)
idTitleAuthorsYear
1
Erythema elevatum diutinum. (23487831)
2013
2
Atypical erythema elevatum diutinum or extrafacial granuloma faciale? (23253514)
2013
3
Successful combination therapy with dapsone and cyclosporine for erythema elevatum diutinum with unusual appearance. (22132683)
2012
4
A case of erythema elevatum diutinum associated with peripheral ulcerative keratitis. (22309340)
2012
5
Erythema elevatum diutinum: an "idiopathic" case. (21810392)
2011
6
Erythema elevatum diutinum mimicking a vesiculobullous disease. (22126877)
2011
7
A case of extensive erosive and bullous erythema elevatum diutinum in a patient diagnosed with human immunodeficiency virus (HIV). (21781074)
2011
8
Is IgA antineutrophil cytoplasmic antibody a marker for patients with erythema elevatum diutinum? A further three cases demonstrating this association. (21143463)
2011
9
Erythema elevatum diutinum as a paraneoplastic syndrome in a patient with pulmonary lymphoepithelioma-like carcinoma. (18571759)
2009
10
Photoclinic. Erythema elevatum diutinum. (18759532)
2008
11
The development of erythema elevatum diutinum in a patient with juvenile idiopathic arthritis under treatment with abatacept. (17932616)
2008
12
Infantile erythema elevatum diutinum: report of a vesiculo-bullous case. (17229612)
2006
13
Erythema elevatum diutinum: clinical, histopathologic, and immunohistochemical characteristics of six patients. (16148408)
2005
14
Erythema elevatum diutinum in the setting of connective tissue disease and chronic bacterial infection. (16357711)
2005
15
Neutrophilic dermatosis of the dorsal hands: a variant of erythema elevatum diutinum? (12533183)
2003
16
Erythema elevatum diutinum. (14594610)
2003
17
Erythema elevatum diutinum in an HIV-positive patient. (12884465)
2003
18
A case of myasthenia gravis accompanied by erythema elevatum diutinum and rheumatoid arthritis. (11437173)
2001
19
Erythema elevatum diutinum/Sweet's syndrome overlap with gastrointestinal and oral involvement. (10583147)
1999
20
Erythema elevatum diutinum in a patient with human herpesvirus 6 infection. (10086876)
1999
21
Erythema elevatum diutinum complicated by rheumatoid arthritis. (10458086)
1999
22
Erythema elevatum diutinum and HIV infection: a report of five cases. (10468812)
1999
23
Erythema elevatum diutinum and AIDS: are they related? (9580188)
1997
24
Nodular erythema elevatum diutinum mimicking cutaneous neoplasms. (9253631)
1997
25
Erythema elevatum diutinum: a clinicopathological study of eight cases. (9185905)
1997
26
Erythema elevatum diutinum associated with pulmonary infiltrates. (9390354)
1997
27
Unusual erythema elevatum diutinum with fibrohistiocytic proliferation. (8763440)
1996
28
Erythema elevatum diutinum. (8002161)
1994
29
Simultaneous occurrence of two rare cutaneous markers of poor prognosis in myelodysplastic syndrome: erythema elevatum diutinum and specific lesions. (8043402)
1994
30
Erythema elevatum diutinum and chronic lymphocytic leukemia. (8050158)
1994
31
Ulcerated nodules on the elbows, fingers, and knees. Erythema elevatum diutinum (EED). (8352608)
1993
32
Ultrastructural study of chronic lesions of erythema elevatum diutinum: "extracellular cholesterosis" is a misnomer. (8340516)
1993
33
Pyoderma gangrenosum in association with erythema elevatum diutinum: report of two cases. (1572226)
1992
34
Erythema elevatum diutinum: a clinicopathological study. (1516248)
1992
35
Erythema elevatum diutinum--a case successfully treated with colchicine. (2605811)
1989
36
Erythema elevatum diutinum and pre-AIDS. (2426910)
1986
37
The evolution of lesions in erythema elevatum diutinum. (3777377)
1986
38
Erythema elevatum diutinum--a report of two unusual patients. (6641012)
1983
39
Erythema elevatum diutinum. A case report. (6642569)
1983
40
Erythema elevatum diutinum treated with niacinamide and tetracycline. (6445715)
1980
41
Erythema elevatum diutinum and IgA myeloma: an interesting association. (902003)
1977
42
ERYTHEMA ELEVATUM DIUTINUM? (14164982)
1964
43
ERYTHEMA ELEVATUM DIUTINUM. (14068149)
1963
44
Erythema elevatum diutinum. A type of allergic vasulitis. (14463051)
1962
45
Erythema elevatum diutinum; report of a case. (13616718)
1959
46
Erythema elevatum diutinum. (14363564)
1955
47
Erythema multiforme perstans (erythema elevatum diutinum). (15440777)
1950
48
Status of erythema elevatum diutinum. (18912481)
1948
49
Eosinophilic granuloma of the skin; its relation to erythema elevatum diutinum and eosinophilic granuloma of the bone; report of a case. (20286475)
1947
50
Erythema Elevatum Diutinum (Case Previously Shown). (19985753)
1927

Variations for Erythema Elevatum Diutinum

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Expression for genes affiliated with Erythema Elevatum Diutinum

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Erythema Elevatum Diutinum

Search GEO for disease gene expression data for Erythema Elevatum Diutinum.

Pathways for genes affiliated with Erythema Elevatum Diutinum

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51PathCards, 5Cell Signaling Technology, 31KEGG, 56Reactome, 61Thomson Reuters, 54QIAGEN
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Compounds for genes affiliated with Erythema Elevatum Diutinum

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46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 3BitterDB, 25HMDB
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Compounds related to Erythema Elevatum Diutinum according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
15 aminosalicylic acid469.9PECAM1, IL8
2azithromycin46 1210.9IL8, CD79A
3polyurethane469.8ITGB2, PECAM1
4clarithromycin46 1210.8IL8, CD79A
5sulfasalazine30 46 52 1212.8CD79A, IL8
6slex469.8ITGB2, PECAM1
7methacholine46 52 1211.8CD79A, IL8
8polycarbonate469.8ITGB2, IL8
9salmeterol46 52 30 1212.7IL8, ITGB2
10piroxicam46 1210.7CD79A, ITGB2
11silicone469.7CD79A, ITGB2
12polymyxin b469.7IL8, ITGB2
13cellulose acetate469.7CD79A, ITGB2
14okt3469.7CD79A, ITGB2
15calyculin a46 62 1211.7PECAM1, ITGB2
16con a469.7CD79A, ITGB2
17rolipram46 62 3011.7IL8, ITGB2
18neopterin469.6CD79A, IL8
19n-formylmethionyl-leucylphenylalanine469.6IL8, ITGB2
20ivig469.6ITGB2, CD79A
21erythromycin46 3 52 1212.6ITGB2, IL8
22pentoxifylline46 1210.6IL8, ITGB2
23reticulin469.5CD79A, F13A1
24fluconazole46 1210.5F13A1, CD79A
25nocodazole46 1210.5ITGB2, CD79A
26hematoxylin469.4PECAM1, F13A1
27leukotriene b446 62 2511.4IL8, ITGB2
28prednisolone46 30 1211.3CD79A, ITGB2
29cytochalasin d46 6210.3PECAM1, ITGB2, IL8
30rantes469.3PECAM1, ITGB2, IL8
31kininogen469.3ITGB2, F13A1
32salbutamol46 52 30 25 1213.3CD79A, IL8, ITGB2
33hyaluronic acid46 2510.2CD79A, IL8, ITGB2
34sodium dodecylsulfate469.2ITGB2, CD79A
35superoxide46 2510.2IL8, ITGB2, PECAM1
36cycloheximide469.2PECAM1, ITGB2, IL8
37lactate469.2ITGB2, IL8, CD79A
38dithiothreitol469.1F13A1, ITGB2
39aspirin46 52 30 2512.1CD79A, F13A1, PECAM1
40paraffin469.0PECAM1, F13A1, CD79A
41dexamethasone46 52 30 1212.0CD79A, IL8, ITGB2
42nitric oxide46 25 1210.9IL8, ITGB2, PECAM1
43histamine46 30 2510.8CD79A, IL8, ITGB2, PECAM1
44cyclosporin a46 30 6210.8PECAM1, ITGB2, IL8, CD79A
45h2o2468.8CD79A, IL8, ITGB2, PECAM1
46cysteine468.8CD79A, IL8, ITGB2, PECAM1
47fibrinogen468.5PECAM1, F13A1, ITGB2, CD79A
48adp46 30 2510.3ITGB2, F13A1, PECAM1
49heparin46 30 25 1211.0CD79A, IL8, ITGB2, F13A1, PECAM1
50vegf468.0PECAM1, F13A1, ITGB2, IL8, CD79A

GO Terms for genes affiliated with Erythema Elevatum Diutinum

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17Gene Ontology
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Biological processes related to Erythema Elevatum Diutinum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1leukocyte migrationGO:0509009.4ITGB2, PECAM1
2neutrophil chemotaxisGO:0305939.3IL8, ITGB2
3platelet degranulationGO:0025768.9F13A1, PECAM1
4blood coagulationGO:0075968.5ITGB2, F13A1, PECAM1

Products for genes affiliated with Erythema Elevatum Diutinum

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Sources for Erythema Elevatum Diutinum

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet