MCID: ERY017
MIFTS: 37

Erythema Elevatum Diutinum malady

Skin diseases, Bone diseases categories

Summaries for Erythema Elevatum Diutinum

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Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Erythema elevatum diutinum is a rare type of chronic cutaneous vasculitis characterized by red, purple, brown or yellow papules, plaques (thick, red patches of skin), or nodules.these lesions are located mainly on the knees, elbows, hands, feet, face, genitals and buttocks. although it is a chronic condition, most cases respond well to treatment with dapsone. the cause of this condition remains unknown.  last updated: 4/13/2010

MalaCards: Erythema Elevatum Diutinum is related to vasculitis and arthritis, and has symptoms including myalgia/muscular pain, subcutaneous nodules/lipomas/tumefaction/swelling and monoclonal immunoglobulins/gammapathy/dysglobulinemia. An important gene associated with Erythema Elevatum Diutinum is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Malaria and Rheumatoid arthritis. The compounds reticulin and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include skin and bone, and related mouse phenotype hematopoietic system.

Wikipedia:63 Erythema elevatum diutinum is a form of vasculitis. more...

Aliases & Classifications for Erythema Elevatum Diutinum

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42NIH Rare Diseases, 48Orphanet, 60UMLS, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
erythema elevatum diutinum:
Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

erythema elevatum diutinum 42 48 60


External Ids:

UMLS via Orphanet61 C0263398
MESH via Orphanet35 C535509
ICD10 via Orphanet26 L95.1
SNOMED-CT via Orphanet57 254757003, 58872001
ICD1025 L95.1

Related Diseases for Erythema Elevatum Diutinum

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17GeneCards, 18GeneDecks
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Diseases related to Erythema Elevatum Diutinum via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis31.0CD79A, ITGB2
2arthritis31.0PECAM1, IL8, ITGB2
3rheumatoid arthritis30.9F13A1, CD79A, IL8, PECAM1, ITGB2
4lupus erythematosus30.7CD79A
5dermatitis30.6CD79A, F13A1, ITGB2
6urticaria30.4ITGB2
7measles30.4CD79A, ITGB2
8sarcoma30.4PECAM1, F13A1
9kaposi's sarcoma30.4PECAM1, F13A1
10diabetes mellitus30.4ITGB2, CD79A, PECAM1
11leukemia30.4PECAM1, CD79A, ITGB2
12ulcerative colitis30.4PECAM1, IL8, CD79A, F13A1, ITGB2
13keratitis10.6
14pyoderma gangrenosum10.6
15pyoderma10.6
16relapsing polychondritis10.5
17celiac disease10.5
18scleritis10.5
19crohn's disease10.3
20hand dermatosis10.3
21porphyria cutanea tarda10.3
22erythema multiforme10.3
23cutaneous lupus erythematosus10.3
24granulomatous dermatitis10.3
25systemic lupus erythematosus10.3
26lymphoepithelioma-like carcinoma10.3
27pseudopterygium10.3
28wegener's granulomatosis10.3
29acquired immunodeficiency syndrome10.3
30verrucous carcinoma10.3
31poems syndrome10.3
32chronic lymphocytic leukemia10.3
33connective tissue disease10.3
34dermatitis herpetiformis10.3
35dermatomyositis10.3
36hodgkin's lymphoma10.3
37laryngitis10.3
38myasthenia gravis10.3
39myeloma10.3
40panniculitis10.3
41panuveitis10.3
42porphyria10.3
43pulmonary fibrosis10.3
44squamous cell carcinoma10.3
45thyroiditis10.3
46coronary heart disease10.0PECAM1
47purpura10.0CD79A
48bronchiolitis10.0IL8
49vascular disease10.0IL8
50periodontitis10.0IL8

Graphical network of the top 20 diseases related to Erythema Elevatum Diutinum:



Diseases related to erythema elevatum diutinum

Clinical Features for Erythema Elevatum Diutinum

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Sources:
48Orphanet
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Symptoms:

48 (show all 9)
  • myalgia/muscular pain
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • monoclonal immunoglobulins/gammapathy/dysglobulinemia
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • articular/joint pain/arthralgia
  • vascularitis/vasculitides/arteritis
  • follicular/erythematous/edematous papules/milium
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • cutaneous rash

Drugs & Therapeutics for Erythema Elevatum Diutinum

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Erythema Elevatum Diutinum

Drug clinical trials:

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Search CenterWatch for Erythema Elevatum Diutinum

Genetic Tests for Erythema Elevatum Diutinum

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Anatomical Context for Erythema Elevatum Diutinum

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32MalaCards
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MalaCards organs/tissues related to Erythema Elevatum Diutinum:

32
Skin, Bone

Animal Models for Erythema Elevatum Diutinum or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Erythema Elevatum Diutinum:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.5PECAM1, IL8, CD79A, F13A1, ITGB2

Publications for Erythema Elevatum Diutinum

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Genetic Variations for Erythema Elevatum Diutinum

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Expression for genes affiliated with Erythema Elevatum Diutinum

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Erythema Elevatum Diutinum

Search GEO for disease gene expression data for Erythema Elevatum Diutinum.

Pathways for genes affiliated with Erythema Elevatum Diutinum

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Sources:
29KEGG, 53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Erythema Elevatum Diutinum

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Erythema Elevatum Diutinum according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1reticulin4410.3CD79A
2pentoxifylline44 1111.0ITGB2
35 aminosalicylic acid449.8IL8, PECAM1
4azithromycin44 1110.8CD79A, IL8
5polyurethane449.8ITGB2, PECAM1
6clarithromycin44 1110.8CD79A, IL8
7rantes449.8PECAM1, ITGB2
8slex449.7ITGB2, PECAM1
9polycarbonate449.7ITGB2, IL8
10sulfasalazine44 28 49 1112.7IL8, CD79A
11salmeterol44 49 28 1112.7ITGB2, IL8
12piroxicam44 1110.7CD79A, ITGB2
13silicone449.7CD79A, ITGB2
14methacholine44 1110.7CD79A, IL8
15polymyxin b449.7IL8, ITGB2
16cellulose acetate449.6CD79A, ITGB2
17okt3449.6ITGB2, CD79A
18con a449.6CD79A, ITGB2
19calyculin a44 59 1111.6ITGB2, PECAM1
20n-formylmethionyl-leucylphenylalanine449.6IL8, ITGB2
21ivig449.5ITGB2, CD79A
22erythromycin44 49 2 1112.5ITGB2, IL8
23fluconazole44 1110.5CD79A, F13A1
24neopterin449.3IL8, CD79A
25h2o2449.3PECAM1, CD79A, ITGB2
26cytochalasin d44 5910.3ITGB2, IL8, PECAM1
27salbutamol44 49 28 11 2413.2IL8, CD79A, ITGB2
28hyaluronic acid44 2410.2IL8, CD79A, ITGB2
29hematoxylin449.2F13A1, PECAM1
30kininogen449.1F13A1, ITGB2
31lactate449.1IL8, CD79A, ITGB2
32aspirin44 49 28 2412.1PECAM1, CD79A, F13A1
33nocodazole44 1110.0CD79A, ITGB2
34dithiothreitol449.0F13A1, ITGB2
35paraffin448.9F13A1, CD79A, PECAM1
36histamine44 28 2410.8ITGB2, CD79A, IL8, PECAM1
37cyclosporin a44 28 5910.8PECAM1, IL8, CD79A, ITGB2
38cysteine448.7ITGB2, CD79A, IL8, PECAM1
39fibrinogen448.5ITGB2, F13A1, CD79A, PECAM1
40heparin44 28 11 2411.0PECAM1, IL8, CD79A, F13A1, ITGB2
41vegf448.0ITGB2, F13A1, CD79A, IL8, PECAM1

GO Terms for genes affiliated with Erythema Elevatum Diutinum

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16Gene Ontology
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Biological processes related to Erythema Elevatum Diutinum according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neutrophil chemotaxisGO:0305939.2IL8, ITGB2
2platelet degranulationGO:0025769.2PECAM1, F13A1
3blood coagulationGO:0075968.3PECAM1, F13A1, ITGB2

Products for genes affiliated with Erythema Elevatum Diutinum

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Erythema Elevatum Diutinum

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet