MCID: ERY017
MIFTS: 43

Erythema Elevatum Diutinum malady

Rare diseases, Skin diseases, Cardiovascular diseases, Bone diseases categories

Aliases & Classifications for Erythema Elevatum Diutinum

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Sources:
42NIH Rare Diseases, 48Orphanet, 61UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Aliases & Descriptions for Erythema Elevatum Diutinum:

Name: Erythema Elevatum Diutinum 42 48 61


Classifications:



Characteristics (Orphanet epidemiological data):

48
erythema elevatum diutinum:
Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Orphanet48 90000
MESH via Orphanet34 C535509
ICD10 via Orphanet26 L95.1
UMLS via Orphanet62 C0263398
ICD1025 L95.1

Summaries for Erythema Elevatum Diutinum

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NIH Rare Diseases:42 Erythema elevatum diutinum is a rare type of chronic cutaneous vasculitis characterized by red, purple, brown or yellow papules, plaques (thick, red patches of skin), or nodules.these lesions are located mainly on the knees, elbows, hands, feet, face, genitals and buttocks. although it is a chronic condition, most cases respond well to treatment with dapsone. the cause of this condition remains unknown.  last updated: 4/13/2010

MalaCards based summary: Erythema Elevatum Diutinum is related to vasculitis and arthritis, and has symptoms including skin rash, vasculitis and arthralgia. An important gene associated with Erythema Elevatum Diutinum is PECAM1 (platelet/endothelial cell adhesion molecule 1), and among its related pathways are Lymphocyte Signaling and Cell adhesion molecules (CAMs). The compounds 5 aminosalicylic acid and azithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and neutrophil, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:64 Erythema elevatum diutinum is a form of vasculitis. more...

Related Diseases for Erythema Elevatum Diutinum

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Graphical network of the top 20 diseases related to Erythema Elevatum Diutinum:



Diseases related to erythema elevatum diutinum

Symptoms for Erythema Elevatum Diutinum

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Symptoms:

 48 (show all 9)
  • cutaneous rash
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • follicular/erythematous/edematous papules/milium
  • vascularitis/vasculitides/arteritis
  • articular/joint pain/arthralgia
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • monoclonal immunoglobulins/gammapathy/dysglobulinemia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • myalgia/muscular pain

HPO human phenotypes related to Erythema Elevatum Diutinum:

(show all 6)
id Description Frequency HPO Source Accession
1 skin rash hallmark (90%) HP:0000988
2 vasculitis hallmark (90%) HP:0002633
3 arthralgia hallmark (90%) HP:0002829
4 abnormal blistering of the skin typical (50%) HP:0008066
5 abnormal immunoglobulin level typical (50%) HP:0010701
6 myalgia occasional (7.5%) HP:0003326

Drugs & Therapeutics for Erythema Elevatum Diutinum

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Drug clinical trials:

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Search NIH Clinical Center for Erythema Elevatum Diutinum

Genetic Tests for Erythema Elevatum Diutinum

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Anatomical Context for Erythema Elevatum Diutinum

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MalaCards organs/tissues related to Erythema Elevatum Diutinum:

31
Skin, Bone, Neutrophil, Liver, Thyroid, Breast, B cells

Animal Models for Erythema Elevatum Diutinum or affiliated genes

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MGI Mouse Phenotypes related to Erythema Elevatum Diutinum:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4CD79A, IL8, ITGB2, PECAM1
2MP:00053977.2CD79A, IL8, ITGB2, F13A1, PECAM1

Publications for Erythema Elevatum Diutinum

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Articles related to Erythema Elevatum Diutinum:

(show top 50)    (show all 173)
idTitleAuthorsYear
1
A case of mistaken identity: unilateral erythema elevatum diutinum associated with IgA paraproteinaemia. (25754401)
2015
2
Nodular Erythema Elevatum Diutinum Mimicking Kaposi's Sarcoma in a Human Immunodeficiency Virus Infected Patient. (25484391)
2014
3
Case of Erythema Elevatum Diutinum Associated With IgA Paraproteinemia Successfully Controlled With Thalidomide and Plasma Exchange. (25257541)
2014
4
Erythema elevatum diutinum. (23487831)
2013
5
Atypical erythema elevatum diutinum or extrafacial granuloma faciale? (23253514)
2013
6
Successful combination therapy with dapsone and cyclosporine for erythema elevatum diutinum with unusual appearance. (22132683)
2012
7
A case of erythema elevatum diutinum associated with peripheral ulcerative keratitis. (22309340)
2012
8
Erythema elevatum diutinum: an "idiopathic" case. (21810392)
2011
9
Erythema elevatum diutinum mimicking a vesiculobullous disease. (22126877)
2011
10
A case of extensive erosive and bullous erythema elevatum diutinum in a patient diagnosed with human immunodeficiency virus (HIV). (21781074)
2011
11
Is IgA antineutrophil cytoplasmic antibody a marker for patients with erythema elevatum diutinum? A further three cases demonstrating this association. (21143463)
2011
12
Erythema elevatum diutinum as a paraneoplastic syndrome in a patient with pulmonary lymphoepithelioma-like carcinoma. (18571759)
2009
13
Photoclinic. Erythema elevatum diutinum. (18759532)
2008
14
The development of erythema elevatum diutinum in a patient with juvenile idiopathic arthritis under treatment with abatacept. (17932616)
2008
15
Infantile erythema elevatum diutinum: report of a vesiculo-bullous case. (17229612)
2006
16
Erythema elevatum diutinum: clinical, histopathologic, and immunohistochemical characteristics of six patients. (16148408)
2005
17
Erythema elevatum diutinum in the setting of connective tissue disease and chronic bacterial infection. (16357711)
2005
18
Neutrophilic dermatosis of the dorsal hands: a variant of erythema elevatum diutinum? (12533183)
2003
19
Erythema elevatum diutinum. (14594610)
2003
20
Erythema elevatum diutinum in an HIV-positive patient. (12884465)
2003
21
A case of myasthenia gravis accompanied by erythema elevatum diutinum and rheumatoid arthritis. (11437173)
2001
22
Erythema elevatum diutinum/Sweet's syndrome overlap with gastrointestinal and oral involvement. (10583147)
1999
23
Erythema elevatum diutinum in a patient with human herpesvirus 6 infection. (10086876)
1999
24
Erythema elevatum diutinum complicated by rheumatoid arthritis. (10458086)
1999
25
Erythema elevatum diutinum and HIV infection: a report of five cases. (10468812)
1999
26
Erythema elevatum diutinum and AIDS: are they related? (9580188)
1997
27
Nodular erythema elevatum diutinum mimicking cutaneous neoplasms. (9253631)
1997
28
Erythema elevatum diutinum: a clinicopathological study of eight cases. (9185905)
1997
29
Erythema elevatum diutinum associated with pulmonary infiltrates. (9390354)
1997
30
Unusual erythema elevatum diutinum with fibrohistiocytic proliferation. (8763440)
1996
31
Erythema elevatum diutinum. (8002161)
1994
32
Simultaneous occurrence of two rare cutaneous markers of poor prognosis in myelodysplastic syndrome: erythema elevatum diutinum and specific lesions. (8043402)
1994
33
Erythema elevatum diutinum and chronic lymphocytic leukemia. (8050158)
1994
34
Ulcerated nodules on the elbows, fingers, and knees. Erythema elevatum diutinum (EED). (8352608)
1993
35
Ultrastructural study of chronic lesions of erythema elevatum diutinum: "extracellular cholesterosis" is a misnomer. (8340516)
1993
36
Pyoderma gangrenosum in association with erythema elevatum diutinum: report of two cases. (1572226)
1992
37
Erythema elevatum diutinum: a clinicopathological study. (1516248)
1992
38
Erythema elevatum diutinum--a case successfully treated with colchicine. (2605811)
1989
39
Erythema elevatum diutinum and pre-AIDS. (2426910)
1986
40
The evolution of lesions in erythema elevatum diutinum. (3777377)
1986
41
Erythema elevatum diutinum--a report of two unusual patients. (6641012)
1983
42
Erythema elevatum diutinum and IgA myeloma: an interesting association. (902003)
1977
43
ERYTHEMA ELEVATUM DIUTINUM? (14164982)
1964
44
ERYTHEMA ELEVATUM DIUTINUM. (14068149)
1963
45
Erythema elevatum diutinum. A type of allergic vasulitis. (14463051)
1962
46
Erythema elevatum diutinum; report of a case. (13616718)
1959
47
Erythema elevatum diutinum. (14363564)
1955
48
Erythema multiforme perstans (erythema elevatum diutinum). (15440777)
1950
49
Status of erythema elevatum diutinum. (18912481)
1948
50
Eosinophilic granuloma of the skin; its relation to erythema elevatum diutinum and eosinophilic granuloma of the bone; report of a case. (20286475)
1947

Variations for Erythema Elevatum Diutinum

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Expression for genes affiliated with Erythema Elevatum Diutinum

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Search GEO for disease gene expression data for Erythema Elevatum Diutinum.

Pathways for genes affiliated with Erythema Elevatum Diutinum

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Compounds for genes affiliated with Erythema Elevatum Diutinum

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Compounds related to Erythema Elevatum Diutinum according to GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
15 aminosalicylic acid449.9IL8, PECAM1
2azithromycin44 1110.9CD79A, IL8
3polyurethane449.8ITGB2, PECAM1
4clarithromycin44 1110.8CD79A, IL8
5sulfasalazine28 44 50 1112.8CD79A, IL8
6slex449.8ITGB2, PECAM1
7methacholine44 50 1111.8CD79A, IL8
8polycarbonate449.8ITGB2, IL8
9salmeterol44 50 28 1112.7ITGB2, IL8
10piroxicam44 1110.7CD79A, ITGB2
11silicone449.7ITGB2, CD79A
12polymyxin b449.7ITGB2, IL8
13cellulose acetate449.7CD79A, ITGB2
14okt3449.7ITGB2, CD79A
15calyculin a44 60 1111.7PECAM1, ITGB2
16con a449.7ITGB2, CD79A
17rolipram44 60 2811.7ITGB2, IL8
18neopterin449.6IL8, CD79A
19n-formylmethionyl-leucylphenylalanine449.6ITGB2, IL8
20ivig449.6CD79A, ITGB2
21erythromycin44 1 50 1112.6IL8, ITGB2
22pentoxifylline44 1110.6IL8, ITGB2
23reticulin449.5CD79A, F13A1
24fluconazole44 1110.5CD79A, F13A1
25nocodazole44 1110.5ITGB2, CD79A
26hematoxylin449.4PECAM1, F13A1
27leukotriene b444 60 2411.4IL8, ITGB2
28prednisolone44 28 1111.3ITGB2, CD79A
29cytochalasin d44 6010.3IL8, ITGB2, PECAM1
30rantes449.3IL8, ITGB2, PECAM1
31kininogen449.3F13A1, ITGB2
32salbutamol44 50 28 24 1113.3ITGB2, IL8, CD79A
33hyaluronic acid44 2410.2CD79A, IL8, ITGB2
34sodium dodecylsulfate449.2ITGB2, CD79A
35superoxide44 2410.2IL8, ITGB2, PECAM1
36cycloheximide449.2PECAM1, IL8, ITGB2
37lactate449.2CD79A, ITGB2, IL8
38dithiothreitol449.1ITGB2, F13A1
39aspirin44 50 28 2412.1PECAM1, F13A1, CD79A
40paraffin449.0CD79A, F13A1, PECAM1
41dexamethasone44 50 28 1112.0IL8, ITGB2, CD79A
42nitric oxide44 24 1110.9IL8, ITGB2, PECAM1
43histamine44 28 2410.8CD79A, PECAM1, ITGB2, IL8
44cyclosporin a44 28 6010.8CD79A, IL8, ITGB2, PECAM1
45h2o2448.8PECAM1, IL8, CD79A, ITGB2
46cysteine448.8ITGB2, PECAM1, IL8, CD79A
47fibrinogen448.5F13A1, PECAM1, ITGB2, CD79A
48adp44 28 2410.3PECAM1, F13A1, ITGB2
49heparin44 28 24 1111.0CD79A, IL8, ITGB2, F13A1, PECAM1
50vegf448.0PECAM1, F13A1, ITGB2, IL8, CD79A

GO Terms for genes affiliated with Erythema Elevatum Diutinum

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Biological processes related to Erythema Elevatum Diutinum according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1leukocyte migrationGO:00509009.4ITGB2, PECAM1
2neutrophil chemotaxisGO:00305939.3IL8, ITGB2
3platelet degranulationGO:00025768.9F13A1, PECAM1
4blood coagulationGO:00075968.5ITGB2, F13A1, PECAM1

Sources for Erythema Elevatum Diutinum

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet