Erythrocytosis malady

Wikipedia: Polycythemia (also known as polycythaemia or polyglobulia) is a disease state in which the proportion of...⁴⁴ more...

MalaCards: Erythrocytosis is related to primary polycythemia and paraganglioma. An important gene associated with Erythrocytosis is EPOR (erythropoietin receptor), and among its related pathways are Akt Signaling and Development Leptin signaling via JAK/STAT and MAPK cascades. The compounds glucose and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and bone marrow, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

erythrocytosis 7 33 32 43

Diseases related to erythrocytosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 452)

id	Related Disease	Score	Top Affiliating Genes
1	primary polycythemia	33.4	EGLN1, EPAS1, EPO, EPOR
2	paraganglioma	29.3	REN, VHL, EGLN1, HIF1A, EPAS1, EPO
3	myelofibrosis	28.1	JAK2, CD177, EPO
4	hypertension	27.7	REN, NOS3, ACE, AGT, AGTR1, EPOR
5	hydronephrosis	27.6	HIF1A, AGTR2, EPO
6	polycystic kidney disease	27.6	VHL, HBA2, EPO
7	erythremia	27.4	HBB, EPO
8	hemangioblastoma	27.0	VHL, HIF1A, TIMP1, EPO, EPOR
9	von hippel-lindau disease	26.9	REN, SETD2, VHL, HIF1A, EPAS1, EPO
10	pheochromocytoma	26.3	REN, SETD2, VHL, ACE, HIF1A, AGTR2
11	polycythemia vera	25.2	KITLG, SELP, BCL2L1, MPL, JAK2, CD177
12	leiomyoma	25.2	IGF1, NOS3, ACE, HIF1A, AGTR2, THBD
13	hypoglycemia	24.9	SETD2, IGFBP3, IGF1, F5, ACE, HBA2
14	renal cell carcinoma	24.8	SELP, SETD2, VHL, BCL2L1, IFNA1, F2RL1
15	polycythemia	24.6	KITLG, SELP, VHL, BCL2L1, MPL, JAK2
16	end stage renal failure	24.6	SELP, IGF1, NOS3, ACE, AGT, AGTR1
17	thalassemia	24.4	JAK2, IL3, IGFBP3, IGF1, IFNA1, F5
18	chronic obstructive pulmonary disease	24.1	REN, SELP, IL11, NOS3, ACE, HIF1A
19	thrombocytosis	24.1	KITLG, SELP, MPL, JAK2, CD177, IL11
20	adenoma	23.2	REN, KITLG, SETD2, VHL, BCL2L1, IL11
21	pulmonary disease	23.0	REN, SELP, SETD2, IL11, IL3, IGFBP3
22	meningioma	21.9	SELP, SETD2, VHL, IL3, IGF1, IFNA1
23	hepatocellular carcinoma	21.0	SELP, SETD2, VHL, BCL2L1, MPL, JAK2
24	neuroblastoma	20.3	KITLG, SELP, SETD2, VHL, BCL2L1, JAK2
25	anemia	20.1	REN, KITLG, SELP, SETD2, VHL, BPGM
26	thrombosis	19.7	REN, SELP, SETD2, VHL, P2RX1, P2RY1
27	hypoxia	19.7	REN, KITLG, SELP, SETD2, VHL, BCL2L1
28	carcinoma	19.1	REN, KITLG, SELP, SETD2, VHL, BCL2L1
29	cerebritis	18.6	REN, KITLG, SELP, SETD2, VHL, BCL2L1
30	hepatitis	18.5	SH2B3, REN, KITLG, SELP, SETD2, VHL
31	neuronitis	16.1	REN, KITLG, SELP, SETD2, VHL, BCL2L1
32	acquired polycythemia	13.7	JAK2, EPO
33	transient erythroblastopenia of childhood	13.7	KITLG, EPO
34	hemorrhagic thrombocythemia	13.7	MPL, JAK2, CD177
35	essential thrombocythemia	13.7	MPL, JAK2
36	sm-ahnmd	13.6	KITLG, JAK2, STAT5A
37	hemoglobin constant spring	13.6	HBA2, HBB
38	congenital hemolytic anemia	13.6	IL3, HBB, EPO
39	sprinting performance	13.6	ACE, HIF1A
40	diamond-blackfan anemia	13.6	IL3, EPO
41	severe congenital neutropenia	13.6	KITLG, JAK2, IL3
42	neonatal anemia	13.6	HBA2, EPO
43	hemoglobinopathy	13.6	HBA2, HBB, EPO
44	chronic myelomonocytic leukemia	13.5	KITLG, MPL, JAK2, STAT5A
45	hereditary spherocytosis	13.5	HBA2, HBB
46	retinal ischemia	13.5	SETD2, BCL2L1, HIF1A
47	endolymphatic sac tumor	13.5	SETD2, VHL, HIF1A, EPO, EPOR
48	beta thalassemia	13.5	HBA2, HBB, EPO
49	posterior urethral valves	13.5	ACE, AGT, AGTR1
50	megakaryocytic leukemia	13.5	KITLG, JAK2, IL11, IL3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to erythrocytosis:

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MGI Mouse Phenotypes related to erythrocytosis:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.4	AFP
2	respiratory system phenotype	MP:0005388	10.0	SELP, EPAS1
3	embryogenesis phenotype	MP:0005380	9.9	EPOR, EPAS1, EGLN1, MPL, VHL, SETD2
4	liver/biliary system phenotype	MP:0005370	9.1	EPO, EPAS1, STAT5A, AGT, HIF1A, HBB
5	hematopoietic system phenotype	MP:0005397	9.0	EPOR, SH2B3, VHL, BCL2L1, EPO, EPAS1
6	immune system phenotype	MP:0005387	8.6	EPOR, EPAS1, HAMP, SLC3A1, STAT5A, AGTR1
7	integument phenotype	MP:0010771	8.5	STAT5A, HBB, HBA2, EGLN1, F2RL1, F5
8	reproductive system phenotype	MP:0005389	8.5	AFP, STAT5A, TIMP1, AGT, HBB, P2RX1
9	skeleton phenotype	MP:0005390	8.4	HIF1A, AGTR2, SLC3A1, EPAS1, HBB, F2RL1
10	normal phenotype	MP:0002873	8.0	EPO, STAT5A, THBD, HIF1A, HBB, IGF1
11	tumorigenesis	MP:0002006	7.8	HIF1A, AGTR2, TIMP1, STAT5A, AFP, ACE
12	adipose tissue phenotype	MP:0005375	7.8	SLC3A1, STAT5A, AGTR2, AGT, ACE, NOS3
13	renal/urinary system phenotype	MP:0005367	7.4	HIF1A, AGT, AGTR1, AGTR2, SLC3A1, HBB
14	muscle phenotype	MP:0005369	7.4	HIF1A, AGT, AGTR2, EPAS1, HBA2, EGLN1
15	cellular phenotype	MP:0005384	6.2	EGLN1, ACE, HBA2, HIF1A, AGTR2, THBD
16	growth/size phenotype	MP:0005378	6.1	HBB, HIF1A, AGT, AGTR1, THBD, STAT5A
17	nervous system phenotype	MP:0003631	5.7	HBB, HIF1A, AGT, AGTR2, THBD, EPAS1
18	mortality/aging	MP:0010768	5.7	HBA2, AGT, AGTR1, AGTR2, THBD, STAT5A
19	cardiovascular system phenotype	MP:0005385	5.0	HBB, HIF1A, AGT, AGTR1, AGTR2, TIMP1
20	homeostasis/metabolism phenotype	MP:0005376	3.6	AFP, EPOR, EPO, EPAS1, HAMP, SLC3A1

Articles related to erythrocytosis:

(show top 50)    (show all 151)

id	Title	Authors	Year	Affiliating Genes
1	A nonsynonymous LNK polymorphism associated with idio pathic erythrocytosis. (21990094)	McMullin M.F.... Tong W.	2011	SH2B3
2	Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis. (20660052)	Bachman E.... Bhasin S.	2010	HAMP
3	Erythrocytosis caused by erythropoietin-producing thy mic carcinoma. (20179983)	Munakata W.... Sakamaki H.	2010	EPO
4	Idiopathic erythrocytosis: a disappearing entity. (20008248)	McMullin M.F.	2009	EPO
5	Mutations in hypoxia-inducible factor and its regula tory molecules in familial erythrocytosis (19915370)	Komatsu N.	2009	HIF1A, VHL, EGLN1
6	Blood p50 evaluation enhances diagnostic definition of isolated erythrocytosis. (18793248)	Rumi E.... Lazzarino M.	2009	JAK2, EPO
7	Erythropoietin production by a hepatic adenoma in a patient with severe erythrocytosis. (19339771)	Vik A.... Hansen J.B.	2009	EPO
8	Spontaneous erythrocytosis in a patient on chronic he modialysis. (19775422)	Adeniyi M.... Tzamaloukas A.H.	2009	EPO
9	Influence of angiotensin I-converting enzyme polymorphism on development of post-transplant erythrocytosis in renal graft recipients. (18339134)	Kedzierska K.... Ciechanowski K.	2008	ACE
10	Genetic causes of erythrocytosis and the oxygen-sensing pathway. (18538455)	Lee F.S.	2008	EPO
11	Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis. (18378852)	Percy M.J.... Lee F.S.	2008	EPAS1, EPO
12	A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis. (18508787)	Martini M.... Larocca L.M.	2008	EPAS1
13	Disturbance in the HIF-1alpha pathway associated with erythrocytosis: further evidences brought by frameshift and nonsense mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene. (17933562)	Al-Sheikh M.... Prehu C.	2008	HIF1A, EGLN1
14	Loss of the JAK2 intramolecular auto-inhibition mechanism is predicted by structural modelling of a novel exon 12 insertion mutation in a case of idiopathic erythrocytosis. (18671703)	Albiero E.... Rodeghiero F.	2008	JAK2
15	Production of erythropoietin and multiple cytokines by metanephric adenoma results in erythrocytosis. (17610479)	Yoshioka K.... Tachibana M.	2007	EPO
16	Application of PRV-1 mRNA expression level and JAK2V617F mutation for the differentiating between polycytemia vera and secondary erythrocytosis and assessment of treatment by interferon or hydroxyurea. (17852451)	Tutaeva V.... Khoroshko N.D.	2007	IFNA1, CD177
17	Human erythropoietin induces lung failure and erythrocytosis in transgenic mice. (17464207)	Kim M.O.... Ryoo Z.Y.	2007	EPO
18	Pathophysiology of anemia and erythrocytosis. (17656101)	Hodges V.M.... Maxwell A.P.	2007	EPO
19	Usefulness of JAK2V617F mutation in distinguishing idiopathic erythrocytosis from polycythemia vera. (16620973)	Rossi D.... Gaidano G.	2007	JAK2
20	Somatic mutations of JAK2 exon 12 as a molecular basis of erythrocytosis. (18055979)	Cazzola M.	2007	JAK2
21	A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove. (17579185)	Percy M.J.... Lee F.S.	2007	VHL, EGLN1
22	JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis. (18056003)	Martinez-Aviles L.... Bellosillo B.	2007	JAK2
23	The JAK2 V617F mutation is absent in patients with erythrocytosis due to high oxygen affinity hemoglobin variants. (16987804)	McClure R.F.... Mai M.	2006	JAK2
24	Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular degeneration. (16690772)	Heinicke K.... Djonov V.	2006	TIMP1, EPO
25	Hb zoeterwoude [beta23(B5)Val-->Ala)]: a new beta-globin variant found in association with erythrocytosis. (15768551)	Harteveld C.L.... Giordano P.C.	2005	HBB
26	Sleep-related hypoxaemia and excessive erythrocytosis in Andean high-altitude natives. (14738229)	Spicuzza L.... Bernardi L.	2004	EPO
27	Post transplant erythrocytosis in hypercalcemic renal transplant recipients. (12814479)	Kurella M.... Smith S.R.	2003	EPO
28	Effects of losartan or enalapril on hemoglobin, circulating erythropoietin, and insulin-like growth factor-1 in patients with and without posttransplant erythrocytosis. (11877580)	Wang A.Y.... Lui S.F.	2002	IGF1, EPO
29	Erythropoietin synthesis by tumour tissues in a patient with uterine myoma and erythrocytosis. (11328280)	Suzuki M.... Sato I.	2001	EPO
30	Comparison of the effects of enalapril and losartan on posttransplantation erythrocytosis in renal transplant recipients: prospective randomized study. (11502994)	Yildiz A.... Sever M.S.	2001	ACE
31	Long-term therapy for postrenal transplant erythrocytosis with ACE inhibitors: efficacy, safety and action mechanisms. (10809436)	Montanaro D.... Mioni G.	2000	ACE, EPO
32	Erythrocytosis and hydronephrosis in a horseshoe kidney (10589125)	Valero Puerta J.A.... LA^pez RodrA-guez L.	1999	EPO
33	A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. (9923445)	Arcasoy M.O.... Forget B.G.	1999	JAK2, STAT5A, EPOR
34	Losartan, an angiotensin II type 1 receptor antagonist, lowers hematocrit in posttransplant erythrocytosis. (9621296)	Julian B.A.... Prchal J.T.	1998	AGTR1
35	Erythrocytosis due to a mutation in the erythropoietin receptor gene. (9488636)	Percy M.J.... Pearson T.C.	1998	EPOR, EPO
36	Effect of the angiotensin-converting enzyme inhibitor enalapril on post-transplant erythrocytosis. (9810784)	Marubayashi S.... Dohi K.	1998	EPO
37	Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. (9192789)	Arcasoy M.O.... Forget B.G.	1997	EPOR
38	Postrenal transplant erythrocytosis, ACE inhibitors and a hypothetical local renin-angiotensin system in the bone marrow. (9247784)	HaznedaroA9lu I.C.	1997	ACE
39	Effect of theophylline on erythrocytosis in chronic o bstructive pulmonary disease. (9224226)	Oren R.... Matzner Y.	1997	EPO
40	Post-renal transplant erythrocytosis. (8921641)	Chien H.C.... Lai M.K.	1996	EPO
41	The myomatous erythrocytosis syndrome: a review. (7501327)	LevGur M.... Levie M.D.	1995	EPO
42	Enalapril treatment of posttransplant erythrocytosis: efficacy independent of circulating erythropoietin levels. (7645558)	Perazella M.... Bia M.J.	1995	ACE, EPO
43	Erythrocytosis complicated by multiple paraganglioma. (8023652)	Terada N.... Furuta S.	1994	EPO
44	A second case of Hb Hanamaki [alpha 2 139(HC1)Lys->Glu beta 2] in an American family with erythrocytosis. (7928378)	Rahbar S.... Ranney H.M.	1994	HBA2
45	Regulation of erythropoietin production in a case of congenital erythropoietin-dependent pure erythrocytosis. (8037189)	Borgna-Pignatti C.... Barosi G.	1994	EPO
46	Erythrocytosis in a 4 year-old child: diagnostic, prognostic, therapeutical problems (7987446)	Zelinsky-Gurung A.... Reinert P.	1994	EPO
47	Hb TrollhAottan [beta 20(B2)Val-->Glu]--a new haemoglobin variant with increased oxygen affinity causing erythrocytosis. (7914875)	Landin B.... Lindoff B.	1994	HBB
48	Erythropoietin synthesis by tumor cells in a case of meningioma associated with erythrocytosis. (8453106)	Bruneval P.... Lacombe C.	1993	EPO
49	Erythrocytosis in patients with renal failure on hemodialysis: study of underlying mechanism by in vitro erythroid culture assay. (8330648)	SHIH L.Y.... Leu M.L.	1993	EPO
50	Post-transplant erythrocytosis: role of erythropoietin and male sex hormones. (1314974)	Chan P.C.... Cheng I.K.	1992	EPO

Genes related to erythrocytosis according to GeneCards:

(show all 40)

id	Symbol	Description	Score	GeneCards Section Context
1	EPOR	erythropoietin receptor	11.1	Publications, Summaries
2	EGLN1	egl nine homolog 1 (C. elegans)	11.1	Summaries, Publications
3	EPAS1	endothelial PAS domain protein 1	11.1	Publications, Summaries
4	ECB2	erythrocytosis, autosomal recessive benign 2	11.0	Aliases & Descriptions
5	JAK2	Janus kinase 2	11.0	Publications
6	EPO	erythropoietin	11.0	Publications
7	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
8	CD177	CD177 molecule	11.0	Publications
9	MPL	myeloproliferative leukemia virus oncogene	11.0	Publications
10	IL11	interleukin 11	11.0	Publications
11	STAT5A	signal transducer and activator of transcription 5A	11.0	Publications
12	HBB	hemoglobin, beta	11.0	Publications
13	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
14	AGTR1	angiotensin II receptor, type 1	11.0	Publications
15	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
16	SETD2	SET domain containing 2	11.0	Publications
17	KITLG	KIT ligand	11.0
18	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
19	BCL2L1	BCL2-like 1	11.0
20	IGFBP3	insulin-like growth factor binding protein 3	11.0
21	BPGM	2,3-bisphosphoglycerate mutase	11.0	Publications
22	SH2B3	SH2B adaptor protein 3	11.0	Publications
23	P2RY1	purinergic receptor P2Y, G-protein coupled, 1	11.0	Publications
24	P2RY12	purinergic receptor P2Y, G-protein coupled, 12	11.0	Publications
25	P2RX1	purinergic receptor P2X, ligand-gated ion channel, 1	11.0	Publications
26	HAMP	hepcidin antimicrobial peptide	11.0	Publications
27	HBA2	hemoglobin, alpha 2	11.0	Publications
28	AGTR2	angiotensin II receptor, type 2	11.0	Publications
29	SLC3A1	solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1	11.0	Publications
30	F2RL1	coagulation factor II (thrombin) receptor-like 1	11.0	Publications
31	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
32	AFP	alpha-fetoprotein	11.0	Publications
33	THBD	thrombomodulin	11.0	Publications
34	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
35	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
36	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
37	REN	renin	11.0	Publications
38	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
39	IFNA1	interferon, alpha 1	11.0	Publications
40	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications

Pathways related to erythrocytosis according to GeneDecks:

(show all 43)

id	Pathway	Score	Top Affiliating Genes
1	Akt Signaling36	10.6	EPOR, IL11
2	Development Leptin signaling via JAK/STAT and MAPK cascades10	10.5	JAK2
3	ACE Inhibitor Pathway, Pharmacodynamics34	10.5	AGTR2, AGTR1
4	Cellular responses to stress38	10.5	EPO, EPAS1, EGLN1, VHL
5	Development_EPO-induced MAPK pathway41	10.3	EPOR, EPO, JAK2, KITLG
6	Development EPO-induced MAPK pathway10	10.3	EPOR, EPO, JAK2, KITLG
7	Development_Thrombopoetin signaling via JAK-STAT pathway41	10.3	STAT5A, JAK2, MPL, BCL2L1
8	Development Thrombopoetin signaling via JAK-STAT pathway10	10.3	STAT5A, JAK2, MPL, BCL2L1
9	Renal cell carcinoma20	10.3	VHL, EGLN1, HIF1A, EPAS1
10	Pathways in cancer20	10.3	EPAS1, STAT5A, HIF1A, BCL2L1
11	Development_EPO-induced Jak-STAT pathway41	10.3	EPOR, EPO, STAT5A, JAK2, BCL2L1
12	Development EPO-induced Jak-STAT pathway10	10.3	EPOR, EPO, STAT5A, JAK2, BCL2L1
13	IL-3 Pathway36	10.3	BCL2L1, JAK2, IL3, STAT5A
14	Signaling by ERBB438	10.2	JAK2, STAT5A
15	Erythropoietin Pathway36	10.2	JAK2, STAT5A, EPO, EPOR
16	Hematopoietic cell lineage20	10.2	EPOR, EPO, IL3, IL11, KITLG
17	Immune response_Oncostatin M signaling via JAK-Stat in human cells41	10.2	STAT5A, TIMP1, JAK2
18	Immune response Oncostatin M signaling via JAK-Stat in human cells10	10.2	STAT5A, TIMP1, JAK2
19	Development_Leptin signaling via JAK/STAT and MAPK cascades41	10.1	TIMP1, JAK2
20	Immune response IL-12 signaling pathway10	10.1	SELP, JAK2, STAT5A
21	Immune response_IL-12 signaling pathway41	10.0	SELP, JAK2, STAT5A
22	Immune response IL-10 signaling pathway10	9.9	BCL2L1, TIMP1, STAT5A
23	Immune response_IL-10 signaling pathway41	9.8	BCL2L1, TIMP1, STAT5A
24	HIF1Alpha Pathway36	9.8	EPO, HIF1A, EGLN1, NOS3, VHL
25	Molecular Mechanisms of Cancer36	9.6	EPOR, TIMP1, HIF1A, IL3, IL11, BCL2L1
26	Renin-angiotensin system20	9.5	AGTR2, AGTR1, AGT, ACE, REN
27	eNOS Signaling36	9.3	EPOR, TIMP1, NOS3, IL3, KITLG
28	Mitochondrial Apoptosis36	9.3	TIMP1, IGF1, IL3, BCL2L1, KITLG
29	DHA Signaling36	9.3	TIMP1, IGF1, IL3, BCL2L1, KITLG
30	GPCR Pathway36	9.3	EPOR, STAT5A, TIMP1, IGF1, IL3, KITLG
31	Cytokine-cytokine receptor interaction20	9.2	EPOR, EPO, IFNA1, IL3, IL11, MPL
32	p70S6K Signaling36	9.2	TIMP1, F2RL1, IGF1, IL3, JAK2, KITLG
33	Tec Kinases Signaling36	9.1	EPOR, STAT5A, TIMP1, IGF1, IL3, IL11
34	Pancreatic Adenocarcinoma36	9.1	EPOR, STAT5A, TIMP1, IGF1, IL3, JAK2
35	mTOR Pathway36	9.1	TIMP1, HIF1A, IGF1, IL3, KITLG
36	Jak-STAT signaling pathway20	9.0	EPOR, EPO, STAT5A, IFNA1, IL3, IL11
37	Cellular Apoptosis Pathway36	8.9	TIMP1, IGF1, IL3, BCL2L1, KITLG
38	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	8.9	AGTR2, AGTR1, AGT, ACE, NOS3, REN
39	Nanog in Mammalian ESC Pluripotency36	8.8	KITLG, IL3, IGF1, TIMP1, EPOR
40	Estrogen Pathway36	8.8	EPOR, TIMP1, NOS3, IGF1, IL3, KITLG
41	Angiogenesis3	8.7	TIMP1, HIF1A, EGLN1, NOS3, F2RL1, VHL
42	Renin-Angiotensin Pathway36	8.2	TIMP1, AGTR2, AGTR1, AGT, ACE, IGF1
43	JAK-STAT Pathway36	7.4	KITLG, EPOR, EPO, STAT5A, TIMP1, AGTR2

Compounds related to erythrocytosis according to GeneDecks:

(show top 50)    (show all 274)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.2	EPAS1, IL11, VHL, SETD2, EPOR
2	rapamycin32 42	11.0	STAT5A, AGT, JAK2, VHL, KITLG
3	h2o232	9.6	AGT, IL3, JAK2, KITLG, AGTR1
4	gp 13032	9.5	EPO, STAT5A, TIMP1, EPOR, JAK2, MPL
5	etoposide32 42 9 9	12.4	BCL2L1, TIMP1, HIF1A, AFP, IL3, SETD2
6	ly29400232	9.4	P2RY12, F2RL1, AGT, STAT5A, EPOR, TIMP1
7	saralasin32 42	10.1	AGTR2, AGTR1, AGT, ACE, REN
8	iron32 18	9.7	VHL, EPOR, EPO, MPL, SETD2, HAMP
9	valsartan32 42 9 9	11.6	AGTR1, AGT, ACE, SELP, AGTR2, TIMP1
10	aprotinin32 9 9	10.6	IGF1, F5, SELP, THBD, AGT
11	perindopril32 34 9 9	11.6	AGTR1, REN, NOS3, ACE, AGT, THBD
12	heparin32 9 18 9	11.5	AFP, KITLG, F2RL1, AGTR1, IL3, TIMP1
13	ang ii32	8.4	AGTR2, AGTR1, AGT, ACE, NOS3, JAK2
14	butyrate32	8.4	JAK2, IGFBP3, TIMP1, EPO, AFP, HBB
15	azathioprine32 34 9 9	11.4	EPO, AFP, IGFBP3, IL11, THBD, TIMP1
16	mycophenolate mofetil32 9 9	10.3	IL11, SELP, THBD, F5, EPO, IL3
17	arachidonic acid32 9 18 9	11.0	AGTR2, F2RL1, IL11, JAK2, P2RY12, P2RY1
18	losartan32 34 9 9	11.0	THBD, AGTR2, AGTR1, AGT, IGF1, REN
19	oligonucleotide32	7.9	HBA2, HBB, IL11, HIF1A, JAK2, AGT
20	candesartan32 9 9	9.9	TIMP1, AGTR2, AGTR1, AGT, HIF1A, ACE
21	paclitaxel32 34 9 9	10.8	IL3, IGFBP3, F5, NOS3, HIF1A, TIMP1
22	cysteine32	7.8	AGTR1, SLC3A1, HBB, TIMP1, SELP, BCL2L1
23	aspirin32 34 18	9.8	TIMP1, JAK2, MPL, P2RY12, P2RY1, P2RX1
24	cisplatin32 34 9 9	10.8	SETD2, IGFBP3, IFNA1, HIF1A, AGTR1, TIMP1
25	wortmannin32 42	8.7	IL3, IL11, JAK2, AGT, IGF1, NOS3
26	sb 20358032 42	8.7	JAK2, NOS3, STAT5A, AGTR1, TIMP1, HIF1A
27	epinephrine32 9 18 9	10.7	AGT, AGTR1, IL11, AFP, REN, KITLG
28	pd 98,05932	7.6	EPAS1, STAT5A, AGT, HIF1A, NOS3, F2RL1
29	norepinephrine32 9 18 9	10.6	AGTR2, AGT, ACE, F2RL1, KITLG, IGFBP3
30	oxygen32 18	8.5	HBA2, KITLG, AGTR2, STAT5A, HAMP, EPOR
31	lactate32	7.4	TIMP1, THBD, EPO, IGFBP3, AFP, SETD2
32	estrogen32	7.2	AFP, IGF1, NOS3, EGLN1, HBB, HIF1A
33	doxorubicin32 34 9 9	10.2	KITLG, SETD2, BCL2L1, IL11, IGFBP3, IFNA1
34	phosphatidylinositol32	7.1	KITLG, SETD2, VHL, BCL2L1, P2RY1, P2RY12
35	genistein32 9 18 9	10.1	BCL2L1, F2RL1, IGF1, NOS3, IL3, AGT
36	thymidine32 18	8.0	HBB, HBA2, F2RL1, IFNA1, IGF1, IGFBP3
37	arginine32	7.0	TIMP1, AGTR2, AGTR1, AGT, P2RX1, HBB
38	prostacyclin32	6.9	AGTR2, AGTR1, AGT, ACE, NOS3, F2RL1
39	cyclosporin a32 42	7.8	IFNA1, F2RL1, HIF1A, AGT, AGTR1, AGTR2
40	cycloheximide32	6.6	KITLG, AGTR1, AGTR2, TIMP1, THBD, STAT5A
41	cholesterol32 9 18 9	9.4	IGFBP3, SELP, AFP, THBD, TIMP1, AGTR1
42	actinomycin d32	6.0	HIF1A, NOS3, F2RL1, IFNA1, IGF1, IL3
43	creatinine32	6.0	KITLG, SELP, IL3, P2RY12, P2RY1, REN
44	alanine32	5.9	P2RX1, MPL, JAK2, IL11, IL3, IGFBP3
45	dexamethasone32 42 34 9 9	9.6	AFP, STAT5A, THBD, TIMP1, AGTR1, AGT
46	retinoic acid32 42 18	7.6	IL11, IL3, IGFBP3, IFNA1, NOS3, HIF1A
47	nitric oxide32 9 18 9	8.4	SELP, SETD2, VHL, P2RY1, JAK2, IL11
48	serine32	4.7	THBD, STAT5A, SLC3A1, EPOR, AFP, TIMP1
49	tyrosine32	4.2	EPO, THBD, IL3, IL11, CD177, JAK2
50	vegf32	4.0	JAK2, IL11, IGFBP3, IGF1, IFNA1, F5

Cellular components related to erythrocytosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	haptoglobin-hemoglobin complex	GO:031838	10.1	HBA2, HBB
2	insulin-like growth factor binding protein complex	GO:016942	9.5	IGFBP3, IGF1
3	integral to plasma membrane	GO:005887	8.0	EPOR, SLC3A1, THBD, AGTR2, AGTR1, F2RL1
4	extracellular region	GO:005576	7.5	AGTR2, TIMP1, HAMP, EPO, EPOR, AGT
5	extracellular space	GO:005615	6.8	REN, AFP, EPO, THBD, AGT, ACE

Biological processes related to erythrocytosis according to GeneDecks:

(show all 40)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of mast cell proliferation	GO:070668	10.4	STAT5A, KITLG
2	negative regulation of mast cell apoptotic process	GO:033026	10.4	STAT5A, KITLG
3	regulation of vasodilation	GO:042312	10.4	P2RY1, ACE, AGTR1
4	positive regulation of NAD(P)H oxidase activity	GO:033864	10.3	AGTR1, AGT
5	regulation of renal output by angiotensin	GO:002019	10.3	AGT, ACE
6	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	10.3	EPO, EPAS1, HIF1A, EGLN1, VHL
7	cellular response to stress	GO:033554	10.3	EPO, EPAS1, HIF1A, EGLN1, VHL
8	cellular response to hypoxia	GO:071456	10.3	EPO, EPAS1, HIF1A, EGLN1, VHL
9	positive regulation of ion transport	GO:043270	10.2	P2RX1, P2RY1, P2RY12
10	regulation of vasoconstriction	GO:019229	10.2	AGTR1, AGT, ACE
11	regulation of blood vessel size by renin-angiotensin	GO:002034	10.2	AGTR1, AGT
12	embryonic hemopoiesis	GO:035162	10.2	HIF1A, IL3, KITLG, SH2B3
13	regulation of systemic arterial blood pressure by renin-angiotensin	GO:003081	10.2	AGTR1, ACE
14	positive regulation of inflammatory response	GO:050729	10.1	STAT5A, AGTR1, AGT, JAK2
15	positive regulation of nitric oxide biosynthetic process	GO:045429	10.1	AGTR2, HBB, JAK2
16	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	GO:007199	10.1	AGTR2, AGT
17	positive regulation of Ras protein signal transduction	GO:046579	10.0	EPO, IGF1, KITLG
18	elevation of cytosolic calcium ion concentration	GO:007204	10.0	P2RY1, JAK2, F2RL1, AGTR1, EPOR
19	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.0	EPO, IGF1, IL3, JAK2
20	renin-angiotensin regulation of aldosterone production	GO:002018	9.9	REN, AGT, AGTR1
21	positive regulation of DNA replication	GO:045740	9.9	EPO, IGF1, IL3, KITLG
22	phospholipase C-activating G-protein coupled receptor signaling pathway	GO:007200	9.8	P2RY1, AGT, AGTR1
23	negative regulation of nerve growth factor receptor signaling pathway	GO:051387	9.8	AGT, AGTR2
24	regulation of renal sodium excretion	GO:035813	9.7	AGTR1, AGT
25	positive regulation of MAPK cascade	GO:043410	9.7	AGT, IGF1, IGFBP3, IL11
26	kidney development	GO:001822	9.7	REN, ACE, AGT, AGTR1
27	positive regulation of vasodilation	GO:045909	9.6	F2RL1, NOS3, AGTR2
28	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	AGT, IGF1, IL3, IL11, JAK2, KITLG
29	G-protein coupled receptor signaling pathway	GO:007186	9.5	AGTR2, AGTR1, AGT, F2RL1, JAK2, P2RY1
30	positive regulation of apoptotic process	GO:043065	9.3	AGTR2, AGT, NOS3, IGFBP3, JAK2
31	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.2	AGT, F2RL1, IGF1, JAK2, SELP
32	positive regulation of cell proliferation	GO:008284	9.2	EPO, TIMP1, IGF1, IL3, IL11, JAK2
33	aging	GO:007568	9.2	EPO, TIMP1, AGT, NOS3, P2RY1
34	regulation of blood pressure	GO:008217	9.0	AGTR2, HBB, ACE, NOS3, P2RX1, REN
35	anti-apoptosis	GO:006916	9.0	EPO, NOS3, IGF1, BCL2L1, VHL
36	platelet degranulation	GO:002576	9.0	SELP, IGF1, F5, TIMP1
37	blood vessel remodeling	GO:001974	9.0	EPAS1, AGTR2, AGT, ACE, NOS3, IGF1
38	negative regulation of cell proliferation	GO:008285	8.7	VHL, JAK2, IGFBP3, IGF1, NOS3, AGT
39	platelet activation	GO:030168	8.2	TIMP1, F5, IGF1, IL11, MPL, P2RY12
40	blood coagulation	GO:007596	6.6	SH2B3, THBD, TIMP1, HBB, NOS3, F2RL1

Molecular functions related to erythrocytosis according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	bradykinin receptor binding	GO:031711	10.2	AGTR1, ACE
2	haptoglobin binding	GO:031720	10.2	HBB, HBA2
3	acetyltransferase activator activity	GO:010698	9.9	AGTR1, AGT
4	protein heterodimerization activity	GO:046982	9.5	EPAS1, SLC3A1, AGTR1, HIF1A, P2RY1, BCL2L1
5	hormone activity	GO:005179	9.3	IGF1, AGT, HAMP, EPO
6	growth factor activity	GO:008083	8.9	AGT, IGF1, IL3, IL11, KITLG
7	protein binding	GO:005515	5.1	EPOR, HBA2, HBB, HIF1A, AGTR1, AGTR2