MCID: ESP020
MIFTS: 49

Esophageal Atresia malady

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Esophageal Atresia

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Aliases & Descriptions for Esophageal Atresia:

Name: Esophageal Atresia 11 47 26 49 38 13 67
Congenital Imperforate Esophagus 11
Congenital Atresia of Esophagus 11
 
Imperforate Esophagus 11
Oesophageal Atresia 11

Classifications:



External Ids:

Disease Ontology11 DOID:10485
ICD1029 Q39.0
MeSH38 D004933
NCIt44 C87072

Summaries for Esophageal Atresia

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Wikipedia:70 Esophageal atresia (or Oesophageal atresia) is a congenital medical condition (birth defect) which... more...

MalaCards based summary: Esophageal Atresia, also known as congenital imperforate esophagus, is related to imperforate anus and esophageal atresia/tracheoesophageal fistula. An important gene associated with Esophageal Atresia is SOX2 (SRY-Box 2), and among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Signaling events mediated by the Hedgehog family. Affiliated tissues include lung, colon and heart, and related mouse phenotypes are taste/olfaction and hearing/vestibular/ear.

Related Diseases for Esophageal Atresia

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Diseases related to Esophageal Atresia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1imperforate anus24.7CHD7, EFTUD2, FANCB, FOXF1, GAL, GLI2
2esophageal atresia/tracheoesophageal fistula12.3
3tracheoesophageal fistula with or without esophageal atresia12.0
4anophthalmia esophageal atresia cryptorchidism11.9
5esophageal atresia coloboma talipes11.9
6anophthalmia-esophageal atresia-genital abnormalities syndrome11.9
7microphthalmia, syndromic 311.8
8tracheoesophageal fistula11.4
9vater/vacterl association11.4
10esophagitis11.0
11fanconi anemia, complementation group b10.9
12arroyo garcia cimadevilla syndrome10.9
13renal agenesis, unilateral10.4GLI3, SHH
14pelizaeus-merzbacher disease in female carriers10.3GLI2, SHH
15x-linked dominant intellectual disability-epilepsy syndrome10.3GLI2, SHH
16x-linked intellectual disability, golabi-ito-hall type10.3GLI2, SHH
17adenosine monophosphate deaminase deficiency erythrocyte type10.3GLI2, GLI3
18x-linked intellectual disability, porteous type10.3GLI2, SHH
19syphilitic myelopathy10.3GLI3, NOG
20homocystinuria without methylmalonic aciduria10.2GLI2, SHH
21fgfr-related craniosynostosis syndromes10.2GLI3, LPP
22malignant neoplasm of acoustic nerve10.2FOXF1, SHH
23tempi syndrome10.2CHD7, MYCN, SHH
24pallister-hall syndrome10.2GLI2, GLI3
25microphthalmia with coloboma 510.2GLI2, SHH
26congenital diaphragmatic hernia10.2
27gastroesophageal reflux10.2
28tracheomalacia10.1
29venezuelan equine encephalitis10.1CHD7, EFTUD2
30melanotic medulloblastoma10.1MYCN, SHH
31dysautonomia, familial10.1GLI2, SHH
32duodenitis10.1
33nodular medulloblastoma10.1GLI2, MYCN
34polydactyly, preaxial, type iv10.1GLI2, GLI3, SHH
35intracranial structure hemangioma10.0GLI2, GLI3, SHH
36hemopericardium10.0GLI2, GLI3, SHH
37duodenal atresia10.0
38agnathia-otocephaly complex10.0GLI2, SHH
39microphthalmia10.0
40hypertrophic pyloric stenosis10.0
41pyloric stenosis10.0
42right aortic arch10.0
43schizencephaly10.0SHH, SOX2
44colorectal cancer, hereditary nonpolyposis, type 19.9FANCB, MYCN
45heart disease9.9
46pharyngitis9.9
47laryngitis9.9
48dysphagia9.9
49digeorge syndrome9.8
50lung agenesis9.8

Graphical network of the top 20 diseases related to Esophageal Atresia:



Diseases related to esophageal atresia

Symptoms for Esophageal Atresia

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Drugs & Therapeutics for Esophageal Atresia

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Drugs for Esophageal Atresia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Omeprazoleapproved, investigational, vet_approvedPhase 333773590-58-64594
Synonyms:
( -)-Omeprazole
(-)-Omeprazole
(S)-(-)-Omeprazole
(S)-Omeprazole
119141-89-8
131959-78-9
172964-80-6
2,3,5-Trimethylpyridine/Omeprazole
2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole
2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
73590-58-6
AC-401
AC1L1IIJ
AGI-010
AKOS005066653
AULCER
Antra
Antra MUPS
Audazol
Aulcer
Axagon
BIDD:GT0189
BPBio1_000425
BRD-A55962179-001-04-9
BSPBio_000385
Belmazol
Bio-0888
C07324
CAS-73590-58-6
CCRIS 7099
CHEBI:519601
CHEBI:7772
CHEMBL1503
CID4594
CPD000058847
Ceprandal
D00455
DB00338
DB00736
DM-3458
Danlox
Demeprazol
Desec
Dizprazol
Dudencer
Elgam
Emeproton
Emilok
Epirazole
Erbolin
Esomeprazole
Esomperazole
Esopral
Exter
Gasec
Gastrimut
Gastroloc
Gibancer
H 168-68
H 168/68
H-168/68
H168/68
HMS1528I05
HMS1569D07
HMS2052G17
HMS2090E16
HMS2090F11
HSDB 3575
I06-0705
IDI1_032523
Indurgan
Inhibitron
Inhipump
LS-7629
Lensor
Logastric
Lomac
Losec
Losec, Omesec, Prilosec, Zegerid, Omeprazole
Lucen
MLS000069373
MLS001076112
MLS001424148
Maybridge4_002645
Mepral
Miol
Miracid
MolPort-003-666-741
MolPort-003-807-515
MolPort-003-849-702
Mopral
Morecon
NCGC00016925-01
 
NCGC00016925-02
NCGC00021522-03
NCGC00021522-04
NCGC00021522-05
Nexiam
Nexium
Nexium IV
Nilsec
Nopramin
Nuclosina
O0359
O104_SIGMA
OMEP
OMP
OMZ
Ocid
Olexin
Olit
Omapren
Omebeta
Omebeta 20
Omed
Omegast
Omepradex
Omepral
Omeprazol
Omeprazol [INN-Spanish]
Omeprazole
Omeprazole (JAN/USP/INN)
Omeprazole Pellets
Omeprazole [USAN:INN:BAN:JAN]
Omeprazole delayed-release
Omeprazole magnesium
Omeprazolum
Omeprazolum [INN-Latin]
Omeprazon
Omeprazone
Omeprol
Omesek
Omez
Omezol
Omezolan
Omid
Omisec
Omizac
Ompanyt
Ortanol
Osiren
Ozoken
Paprazol
Parizac
Pepticum
Pepticus
Peptilcer
Prazentol
Prazidec
Prazolit
Prestwick0_000493
Prestwick1_000493
Prestwick2_000493
Prestwick3_000493
Prestwick_808
Prilosec
Prilosec (TN)
Prilosec OTC
Procelac
Proclor
Prysma
Ramezol
Regulacid
Result
S1389_Selleck
SAM001246900
SAN-15
SMR000058847
SPBio_002306
STK623746
Sanamidol
Secrepina
TL8005099
Tedec Ulceral
UNII-KG60484QX9
UPCMLD-DP075
UPCMLD-DP075:001
Ulceral
Ulcesep
Ulcometion
Ulcozol
Ulcsep
Ulsen
Ultop
Ulzol
Victrix
Zefxon
Zegerid
Zepral
Zimor
Zoltum
esomeprazol
omeprazole
2
RopivacaineapprovedPhase 374184057-95-471273, 175805
Synonyms:
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
(S)-(−)-1-propyl-2',6'-pipecoloxylidide
(S)-ropivacaine
84057-95-4
98717-15-8
AC1L41QM
AC1L41QN
BIDD:GT0203
C07532
C17H26N2O.HCl
CHEBI:8890
CHEMBL1077896
CID175804
CID175805
CPD000469137
D08490
I14-176
L-N-n-propylpipecolic acid-2,6-xylidide
LS-113954
 
MLS001401363
MolPort-003-983-292
NCGC00164597-01
Naropin
Naropin (TN)
ROPIVACAINE HCl
Ropivacaina
Ropivacaina [INN-Spanish]
Ropivacaina [Spanish]
Ropivacaine
Ropivacaine [INN]
Ropivacaine hydrochloride
Ropivacaine monohydrochloride
Ropivacainum
Ropivacainum [INN-Latin]
S-Ropivacaine
SAM001246524
SMR000469137
ST51051452
ropivacaine monohydrochloride,
ropivacaine monohydrochloride, (S)-isomer
3
Proton pump inhibitorsPhase 31080
Synonyms:
 
PPIs
4AntacidsPhase 31767
5Anti-Ulcer AgentsPhase 31767
6Gastrointestinal AgentsPhase 38109
7Peripheral Nervous System AgentsPhase 322776
8Central Nervous System DepressantsPhase 312806
9AnestheticsPhase 39001
10Anesthetics, LocalPhase 33272
11
Nitric Oxideapproved59910102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
12Trace Elements5802
13Pharmaceutical Solutions7793
14Micronutrients5802
15Vitamins5095
16lysineNutraceutical90

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.Unknown statusNCT00226044Phase 3
2Blood Ropivacaine Concentrations Following Nerve Block in Infants and Toddlers Undergoing Esophageal Atresia RepairNot yet recruitingNCT02860091Phase 3
3Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood GasesUnknown statusNCT01467245
4Esophageal Atresia: Metaplasia, BarrettCompletedNCT02495051
5Study in Children With the Diagnosis of Congenital Diaphragmatic Hernia (CDH) and Oesophageal Atresia (EA)CompletedNCT02466451
6Determination of Lysine Requirement in the Parenterally Fed NeonateCompletedNCT00779753
7National Register of Oesophageal AtresiaRecruitingNCT02883725
8Dumping Syndrome After Operation of Esophageal Atresia Type IIIRecruitingNCT02525705
9Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic SurgeryEnrolling by invitationNCT02033772
10Individualized Management for Long Gap Esophageal AtresiaNot yet recruitingNCT03023865
11Chewing in Children With Repaired Esophageal Atresia-tracheoesophageal FistulaNot yet recruitingNCT03026491

Search NIH Clinical Center for Esophageal Atresia


Cochrane evidence based reviews: esophageal atresia

Genetic Tests for Esophageal Atresia

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Genetic tests related to Esophageal Atresia:

id Genetic test Affiliating Genes
1 Esophageal Atresia26

Anatomical Context for Esophageal Atresia

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MalaCards organs/tissues related to Esophageal Atresia:

35
Lung, Colon, Heart, Trachea, Brain, Pancreas, Bone

Animal Models for Esophageal Atresia or affiliated genes

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MGI Mouse Phenotypes related to Esophageal Atresia:

40 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.9GLI3, NOG, SHH, SOX2
2MP:00053779.2CHD7, GLI2, GLI3, NOG, SHH, SOX2
3MP:00107719.0GAL, GLI2, GLI3, NOG, SHH, SOX2
4MP:00053719.0CHD7, GLI2, GLI3, MYCN, NOG, SHH
5MP:00053828.8CHD7, GLI2, GLI3, MYCN, NOG, SHH
6MP:00053698.8CHD7, FOXF1, GLI2, MYCN, NOG, SHH
7MP:00053908.6CHD7, GLI2, GLI3, MYCN, NOG, SHH
8MP:00053818.4CHD7, FOXF1, GLI2, GLI3, MYCN, NOG
9MP:00053808.4CHD7, FOXF1, GLI2, GLI3, MYCN, NOG
10MP:00053888.3CHD7, FOXF1, GLI2, GLI3, MYCN, NOG
11MP:00036318.2CHD7, GAL, GLI2, GLI3, MYCN, NOG
12MP:00053917.9CHD7, GLI2, GLI3, MYCN, NOG, SHH
13MP:00053797.9CHD7, FANCB, GAL, GLI2, GLI3, NOG
14MP:00053787.4CHD7, FANCB, GAL, GLI2, GLI3, MYCN
15MP:00107687.4CHD7, EFTUD2, FOXF1, GLI2, GLI3, LPP
16MP:00053846.8CHD7, FANCB, GAL, GLI2, GLI3, LPP
17MP:00053766.8CHD7, FANCB, GAL, GLI2, GLI3, LPP
18MP:00053896.7CHD7, FANCB, GAL, GLI2, GLI3, LPP

Publications for Esophageal Atresia

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Articles related to Esophageal Atresia:

(show top 50)    (show all 717)
idTitleAuthorsYear
1
Preliminary Study of Video-Based Pediatric Endoscopic Surgical Skill Assessment Using a Neonatal Esophageal Atresia/Tracheoesophageal Fistula Model. (27858521)
2017
2
Pure Esophageal Atresia without a Gap: An Unusual Variant. (27123408)
2016
3
Thoracoscopic Esophageal Atresia with Tracheoesophageal Fistula Repair: The First Iranian Group Report, Passing the Learning Curve. (27471677)
2016
4
EVALUATION OF RISK FACTORS AFFECTING ANASTOMOTIC LEAKAGE AFTER REPAIR OF ESOPHAGEAL ATRESIA. (26537137)
2015
5
Dysphagia among adult patients who underwent surgery for esophageal atresia. (25803019)
2015
6
Long-term esophageal and respiratory outcomes in children with esophageal atresia and tracheoesophageal fistula. (26475129)
2015
7
Thoracoscopic repair of esophageal atresia with tracheoesophageal fistula: overcoming the learning curve. (25475795)
2014
8
Efficacy and histopathological esophageal wall damage of biodegradable esophageal stents for treatment of severe refractory esophageal anastomotic stricture in a child with long gap esophageal atresia. (25399341)
2014
9
The diagnosis of fetal esophageal atresia and its implications on perinatal outcome. (25056797)
2014
10
Early experience of thoracoscopic aortopexy for severe tracheomalacia in infants after esophageal atresia and tracheo-esophageal fistula repair. (24987844)
2014
11
Long-gap esophageal atresia: traction-growth and anastomosis - before and beyond. (23679026)
2013
12
Operative intercostal chest drain is not required following extrapleural or transpleural esophageal atresia repair. (23172565)
2013
13
Minimally invasive repair of esophageal atresia: an update. (23720207)
2013
14
Evaluation of gastroesophageal function and mechanisms underlying gastroesophageal reflux in infants and adults born with esophageal atresia. (24314193)
2013
15
Oto-facial syndrome and esophageal atresia, intellectual disability and zygomatic anomalies - expanding the phenotypes associated with EFTUD2 mutations. (23879989)
2013
16
Mortality in esophageal atresia: Assessment of probable risk factors (10 years' experience). (23626630)
2012
17
Comparison of neonatal tolerance to thoracoscopic and open repair of esophageal atresia with tracheoesophageal fistula. (23044311)
2012
18
Re: Novel use of glycopyrrolate (Robinul) in the treatment of anastomotic leak after repair of esophageal atresia and trachea-esophageal fistula. (23084219)
2012
19
Delayed primary anastomosis for management of long-gap esophageal atresia: a meta-analysis of complications and long-term outcome. (22875461)
2012
20
Incidence, diagnosis, and outcomes of vocal fold immobility after esophageal atresia (EA) and/or tracheoesophageal fistula (TEF) repair. (22169990)
2011
21
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
22
Anastomotic stricture after surgical repair of esophageal atresia: frequency, risk factors, and efficacy of esophageal bougie dilatations. (20638524)
2010
23
Association of gastric heterotopic pancreas and esophageal atresia in children. (19841595)
2010
24
Thoracoscopic repair of congenital esophageal atresia in infants. (19243269)
2009
25
Repair of long-gap esophageal atresia: gastric conduits may improve outcome-a 20-year single center experience. (19707773)
2009
26
Esophageal Atresia: Migration of the gastrostomy tube into the bronchus. (20011489)
2008
27
Long gap esophageal atresia and arterial circle of Willis variant leading to ischemic stroke during gastric transposition. (18437659)
2008
28
Respiratory and gastrointestinal symptoms in esophageal atresia. (19490655)
2008
29
MCRA of an anastomotic stenosis after esophagoesophagostomy for long gap esophageal atresia: a case report. (17502180)
2007
30
Membranous diaphragm presenting as esophageal atresia in a neonate. (17965801)
2007
31
Faulty bone morphogenetic protein signaling in esophageal atresia with tracheoesophageal fistula. (16818050)
2006
32
Bone morphogenetic protein expression patterns in human esophageal atresia with tracheoesophageal fistula. (16315037)
2006
33
Efficacy of postoperative elective ventilatory support for leakage protection in primary anastomosis of congenital esophageal atresia. (16736216)
2006
34
Esophageal atresia with double tracheoesophageal fistula--a case report and review of the literature. (16254849)
2005
35
Reflux in esophageal atresia, tracheoesophageal cleft, and esophagocoloplasty: Bianchi's procedure as an alternative approach. (15852275)
2005
36
Benefits of the thoracoscopic approach for short- or long-gap esophageal atresia. (16366882)
2005
37
Appendiceal mass in a neonate after surgery for esophageal atresia and tracheoesophageal fistula: report of a case. (15622470)
2005
38
Absence of deletion at the SOX2 locus in a case of microphthalmia and esophageal atresia. (15487011)
2004
39
Long gap esophageal atresia and esophageal replacement: moving toward a separation? (15213904)
2004
40
Lengthening technique for long gap esophageal atresia and early anastomosis. (12720183)
2003
41
Endoscopic follow-up in esophageal atresia-for how long is it necessary? (12720174)
2003
42
Thoracoscopic repair of esophageal atresia with distal fistula. (12632124)
2003
43
The distal pouch in esophageal atresia -- to dissect or not to dissect, that is the question. (11967754)
2002
44
A technique to facilitate nursing care in patients with long-gap esophageal atresia. (12598982)
2002
45
Preoperative tracheoscopy in neonates with esophageal atresia. (12456480)
2002
46
Wide-gap esophageal atresia. (11727069)
2001
47
Elective, postoperative ventilation in the management of esophageal atresia and tracheoesophageal fistula. (9099641)
1997
48
Coexisting left congenital diaphragmatic hernia and esophageal atresia with tracheoesophageal fistula: successful management in a premature neonate. (8811578)
1996
49
Esophageal atresia, coloboma, and clubfoot in two unrelated infants. (6469248)
1984
50
Imperforate anus combined with esophageal atresia and agenesis of the right kidney. A case report. (4812382)
1974

Variations for Esophageal Atresia

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Expression for genes affiliated with Esophageal Atresia

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Search GEO for disease gene expression data for Esophageal Atresia.

Pathways for genes affiliated with Esophageal Atresia

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GO Terms for genes affiliated with Esophageal Atresia

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Cellular components related to Esophageal Atresia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ciliary baseGO:00975469.2GLI2, GLI3
2nuclear speckGO:00166079.2EFTUD2, GLI2, GLI3

Biological processes related to Esophageal Atresia according to GeneCards Suite gene sharing:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1lung lobe morphogenesisGO:006046310.5FOXF1, SHH
2respiratory tube developmentGO:003032310.5FOXF1, SHH
3negative regulation of alpha-beta T cell differentiationGO:004663910.5GLI3, SHH
4trachea developmentGO:006043810.5FOXF1, SHH
5positive regulation of alpha-beta T cell differentiationGO:004663810.4GLI3, SHH
6artery developmentGO:006084010.4GLI3, SHH
7prostatic bud formationGO:006051310.4GLI2, NOG
8smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:002193810.4GLI2, SHH
9ventral midline developmentGO:000741810.4GLI2, SHH
10positive regulation of T cell differentiation in thymusGO:003308910.3GLI2, SHH
11embryonic foregut morphogenesisGO:004861710.3FOXF1, SHH
12tube developmentGO:003529510.3GLI2, GLI3
13smoothened signaling pathway involved in spinal cord motor neuron cell fate specificationGO:002177610.3GLI2, GLI3
14smoothened signaling pathway involved in ventral spinal cord interneuron specificationGO:002177510.3GLI2, GLI3
15smoothened signaling pathway involved in dorsal/ventral neural tube patterningGO:006083110.2GLI2, GLI3
16lung morphogenesisGO:006042510.2FOXF1, NOG, SHH
17negative thymic T cell selectionGO:004506010.1GLI3, SHH
18embryonic digestive tract morphogenesisGO:004855710.1FOXF1, GLI3, SHH
19pituitary gland developmentGO:002198310.0GLI2, NOG, SOX2
20spinal cord dorsal/ventral patterningGO:002151310.0GLI2, GLI3, SHH
21camera-type eye developmentGO:00430109.9CHD7, GLI3, SHH
22hindgut morphogenesisGO:00074429.9GLI2, GLI3, SHH
23anatomical structure developmentGO:00488569.9GLI2, GLI3, SHH
24inner ear developmentGO:00488399.9GLI3, SHH, SOX2
25spinal cord motor neuron differentiationGO:00215229.9GLI2, GLI3, SHH
26positive regulation of mesenchymal cell proliferationGO:00020539.9FOXF1, MYCN, SHH
27palate developmentGO:00600219.8CHD7, GLI3, SHH
28neural tube developmentGO:00219159.8GLI2, GLI3, NOG
29anterior/posterior pattern specificationGO:00099529.8GLI2, GLI3, SHH
30osteoblast differentiationGO:00016499.8GLI2, NOG, SOX2
31odontogenesis of dentin-containing toothGO:00424759.7GLI2, GLI3, SHH
32embryonic digestive tract developmentGO:00485669.7FOXF1, GLI2, GLI3
33limb developmentGO:00601739.7CHD7, GLI3, NOG, SHH
34developmental growthGO:00485899.6GLI2, GLI3, SHH
35forebrain developmentGO:00309009.5GLI3, SHH, SOX2
36negative regulation of canonical Wnt signaling pathwayGO:00900909.5GLI3, NOG, SHH, SOX2
37dorsal/ventral pattern formationGO:00099539.5GLI2, GLI3, NOG, SHH
38pattern specification processGO:00073899.5GLI2, GLI3, NOG, SHH
39anatomical structure formation involved in morphogenesisGO:00486469.4GLI2, GLI3, NOG, SHH
40branching morphogenesis of an epithelial tubeGO:00487549.4GLI2, GLI3, MYCN, SHH
41smoothened signaling pathwayGO:00072249.4FOXF1, GLI2, GLI3, SHH
42central nervous system developmentGO:00074179.2CHD7, GLI3, NOG, SHH
43heart developmentGO:00075079.1FOXF1, GLI2, GLI3, SHH
44axon guidanceGO:00074119.1GLI2, GLI3, NOG, SHH
45in utero embryonic developmentGO:00017019.1CHD7, FOXF1, GLI2, GLI3, NOG
46embryonic digit morphogenesisGO:00427339.0GLI2, GLI3, MYCN, NOG, SHH
47lung developmentGO:00303248.8FOXF1, GLI2, GLI3, MYCN, SHH
48positive regulation of transcription, DNA-templatedGO:00458938.5FOXF1, GLI2, GLI3, MYCN, SHH, SOX2
49negative regulation of transcription from RNA polymerase II promoterGO:00001228.0FOXF1, GLI2, GLI3, NOG, SHH, SOX2
50positive regulation of transcription from RNA polymerase II promoterGO:00459447.0CHD7, FOXF1, GAL, GLI2, GLI3, MYCN

Molecular functions related to Esophageal Atresia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010779.6GLI2, GLI3, SOX2
2transcription regulatory region DNA bindingGO:00442129.2FOXF1, GLI2, SOX2
3sequence-specific DNA bindingGO:00435658.9FOXF1, GLI2, GLI3, SOX2

Sources for Esophageal Atresia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet