MCID: ESP020
MIFTS: 46

Esophageal Atresia malady

Rare diseases, Fetal diseases, Gastrointestinal diseases categories

Aliases & Classifications for Esophageal Atresia

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 59SNOMED-CT, 42NCIt, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Esophageal Atresia:

Name: Esophageal Atresia 10 45 47 12 51 65 36
Congenital Imperforate Esophagus 10
Congenital Atresia of Esophagus 10
 
Imperforate Esophagus 10
Oesophageal Atresia 10


Classifications:



Characteristics (Orphanet epidemiological data):

51
esophageal atresia:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe),1-5/10000 (Austria),1-5/10000 (Belgium),1-5/10000 (Croatia),1-5/10000 (Denmark),1-5/10000 (France),1-5/10000 (Germany),1-5/10000 (Hungary),1-5/10000 (Ireland),1-5/10000 (Italy),1-5/10000 (Malta),1-5/10000 (Netherlands),1-5/10000 (Norway),1-9/100000 (Poland),1-5/10000 (Portugal),1-5/10000 (Spain),1-5/10000 (Switzerland),1-5/10000 (United Kingdom),1-5/10000 (Ukraine); Age of onset: Neonatal


External Ids:

Disease Ontology10 DOID:10485
NCIt42 C87072
MeSH36 D004933
Orphanet51 1199
ICD10 via Orphanet28 Q39.0, Q39.1
MESH via Orphanet37 D004933
UMLS via Orphanet66 C0014850

Summaries for Esophageal Atresia

About this section
Wikipedia:68 Esophageal atresia (or Oesophageal atresia) is a congenital medical condition (birth defect) which... more...

MalaCards based summary: Esophageal Atresia, also known as congenital imperforate esophagus, is related to intestinal atresia and esophagitis. An important gene associated with Esophageal Atresia is SOX2 (SRY (Sex Determining Region Y)-Box 2), and among its related pathways are Signaling events mediated by the Hedgehog family and Wnt / Hedgehog / Notch. Affiliated tissues include lung, colon and heart, and related mouse phenotypes are taste/olfaction and no phenotypic analysis.

Related Diseases for Esophageal Atresia

About this section

Diseases related to Esophageal Atresia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1intestinal atresia27.6CHD7, EFTUD2, FANCB, FOXF1, GLI2, GLI3
2esophagitis11.4
3tracheoesophageal fistula11.2
4esophageal atresia/tracheoesophageal fistula10.7
5gastroesophageal reflux10.6
6congenital diaphragmatic hernia10.6
7tracheomalacia10.6
8microphthalmia, syndromic 310.5
9duodenitis10.5
10vacterl association10.5
11duodenal atresia10.5
12hypertrophic pyloric stenosis10.4
13microphthalmia10.4
14imperforate anus10.4
15pyloric stenosis10.4
16dysphagia10.4
17right aortic arch10.4
18pharyngitis10.3
19situs inversus10.3
20laryngitis10.3
21anophthalmia esophageal atresia cryptorchidism10.3
22feingold syndrome10.3
23choanal atresia10.3
24tracheal stenosis10.3
25congenital heart disease10.3
26esophageal atresia coloboma talipes10.3
27lung agenesis10.3
28anophthalmia-esophageal atresia-genital abnormalities syndrome10.3
29swallowing disorders10.3
30charge syndrome10.2
31digeorge syndrome10.2
32dumping syndrome10.2
33cerebritis10.2
34microcephaly10.2
35omphalocele10.2
36cervicitis10.2
37esophageal disease10.2
38pneumonia10.2
39stomach disease10.2
40laryngeal cleft10.2
41sirenomelia10.2
42tricuspid atresia10.2
43anophthalmia/microphthalmia10.2
44dysautonomia10.2
45esophageal duplication cyst10.2
46goiter, multinodular 1, with or without sertoli-leydig cell tumors10.2MYCN, SHH
47fbln5-related cutis laxa10.1GLI3, LPP
48pelizaeus-merzbacher-like disease due to gjc2 mutation10.1GLI2, SHH
49cleft lip10.1
50meckel's diverticulum10.1

Graphical network of the top 20 diseases related to Esophageal Atresia:



Diseases related to esophageal atresia

Symptoms for Esophageal Atresia

About this section

Drugs & Therapeutics for Esophageal Atresia

About this section

Drugs for Esophageal Atresia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Omeprazoleapproved, investigationalPhase 329973590-58-64594
Synonyms:
( -)-Omeprazole
(-)-Omeprazole
(S)-(-)-Omeprazole
(S)-Omeprazole
119141-89-8
131959-78-9
172964-80-6
2,3,5-Trimethylpyridine/Omeprazole
2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole
2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
73590-58-6
AC-401
AC1L1IIJ
AGI-010
AKOS005066653
AULCER
Antra
Antra MUPS
Audazol
Aulcer
Axagon
BIDD:GT0189
BPBio1_000425
BRD-A55962179-001-04-9
BSPBio_000385
Being Well Omeprazole
Belmazol
Bio-0888
C07324
CAS-73590-58-6
CCRIS 7099
CHEBI:519601
CHEBI:7772
CHEMBL1503
CID4594
CPD000058847
Care One Omeprazole
Ceprandal
D00455
DB00338
DB00736
DM-3458
Danlox
Demeprazol
Desec
Dg Health Omeprazole
Dizprazol
Dudencer
Elgam
Emeproton
Emilok
Epirazole
Equaline Omeprazole
Equate Omeprazole Delayed Release acid reducer
Erbolin
Esomeprazole
Esomperazole
Esopral
Exchange Select Omeprazole
Exter
Family Wellness Omeprazole
Formu Care Omeprazole
Fulton Street Market Omeprazole
Gasec
Gastrimut
Gastroloc
Gibancer
Good Neighbor Pharmacy Omeprazole
Good Sense Omeprazole
H 168-68
H 168/68
H-168/68
H168/68
HMS1528I05
HMS1569D07
HMS2052G17
HMS2090E16
HMS2090F11
HSDB 3575
Harmon Face Values Omeprazole
Health Mart Omeprazole
Healthy Accents Omeprazole
I06-0705
IDI1_032523
Indurgan
Inhibitron
Inhipump
Kirkland Signature Omeprazole
LS-7629
Leader Omeprazole
Lensor
Logastric
Lomac
Losec
Losec, Omesec, Prilosec, Zegerid, Omeprazole
Lucen
MLS000069373
MLS001076112
MLS001424148
Maybridge4_002645
Members Mark Omeprazole
Mepral
Miol
Miracid
MolPort-003-666-741
MolPort-003-807-515
MolPort-003-849-702
Mopral
 
Morecon
NCGC00016925-01
NCGC00016925-02
NCGC00021522-03
NCGC00021522-04
NCGC00021522-05
Nexiam
Nexium
Nexium IV
Nilsec
Nopramin
Nuclosina
O0359
O104_SIGMA
OMEP
OMP
OMZ
Ocid
Olex
Olexin
Olit
Omapren
Omebeta
Omebeta 20
Omed
Omegast
Omepradex
Omepral
Omeprazol
Omeprazol [INN-Spanish]
Omeprazole
Omeprazole (JAN/USP/INN)
Omeprazole Delayed Release
Omeprazole Delayed-release
Omeprazole Magnesium
Omeprazole Pellets
Omeprazole [USAN:INN:BAN:JAN]
Omeprazole delayed-release
Omeprazole magnesium
Omeprazole sodium
Omeprazolum
Omeprazolum [INN-Latin]
Omeprazon
Omeprazone
Omeprol
Omesec
Omesek
Omez
Omezol
Omezolan
Omid
Omisec
Omizac
Ompanyt
Ortanol
Osiren
Ozoken
Paprazol
Parizac
Pepticum
Pepticus
Peptilcer
Prazentol
Prazidec
Prazolit
Preferred Plus Omeprazole
Prestwick0_000493
Prestwick1_000493
Prestwick2_000493
Prestwick3_000493
Prestwick_808
Prilosec
Prilosec (TN)
Prilosec OTC
Procelac
Proclor
Prysma
Quality Choice Omeprazole
Ramezol
Regulacid
Result
S1389_Selleck
SAM001246900
SAN-15
SMR000058847
SPBio_002306
STK623746
Sanamidol
Secrepina
Shoprite Omeprazole
Simply Right Omeprazole
Smart Sense Omeprazole
Sunmark Omeprazole
TL8005099
Tedec Ulceral
Topcare Omeprazole
UNII-KG60484QX9
UPCMLD-DP075
UPCMLD-DP075:001
Ulceral
Ulcesep
Ulcometion
Ulcozol
Ulcsep
Ulsen
Ultop
Ulzol
Victrix
Zefxon
Zegerid
Zepral
Zimor
Zoltum
esomeprazol
omeprazole
2
Nitric Oxideapproved54010102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
Inomax
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
3lysineNutraceutical70

Interventional clinical trials:

idNameStatusNCT IDPhase
1Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.RecruitingNCT00226044Phase 3
2Esophageal Atresia: Metaplasia, BarrettCompletedNCT02495051
3Study in Children With the Diagnosis of CDH and EACompletedNCT02466451
4Determination of Lysine Requirement in the Parenterally Fed NeonateCompletedNCT00779753
5Dumping Syndrome After Operation of Esophageal Atresia Type IIIRecruitingNCT02525705
6Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood GasesRecruitingNCT01467245
7Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic SurgeryEnrolling by invitationNCT02033772

Search NIH Clinical Center for Esophageal Atresia


Cochrane evidence based reviews: Esophageal Atresia

Genetic Tests for Esophageal Atresia

About this section

Anatomical Context for Esophageal Atresia

About this section

MalaCards organs/tissues related to Esophageal Atresia:

33
Lung, Colon, Heart, Trachea, Pancreas, Brain, Bone

Animal Models for Esophageal Atresia or affiliated genes

About this section

MGI Mouse Phenotypes related to Esophageal Atresia:

38 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.9GLI3, NOG, SHH, SOX2
2MP:00030129.0GLI2, GLI3, MYCN, SHH, SOX2
3MP:00053718.6CHD7, GLI2, GLI3, MYCN, NOG, SHH
4MP:00053698.6FOXF1, GLI2, MYCN, NOG, SHH, SOX2
5MP:00053778.1CHD7, GLI2, GLI3, NOG, SHH, SOX2
6MP:00053907.8CHD7, GLI2, GLI3, MYCN, NOG, SHH
7MP:00053827.8CHD7, GLI2, GLI3, MYCN, NOG, SHH
8MP:00053797.7CHD7, GLI2, GLI3, NOG, SHH, SOX2
9MP:00053917.6CHD7, GLI2, GLI3, MYCN, NOG, SHH
10MP:00053787.5CHD7, GLI2, GLI3, MYCN, NOG, SHH
11MP:00036317.4CHD7, GLI2, GLI3, MYCN, NOG, SHH
12MP:00053767.4CHD7, GLI2, GLI3, LPP, MYCN, NOG
13MP:00053817.3CHD7, FOXF1, GLI2, GLI3, MYCN, NOG
14MP:00053807.2CHD7, FOXF1, GLI2, GLI3, MYCN, NOG
15MP:00053847.2CHD7, GLI2, GLI3, LPP, MYCN, NOG
16MP:00053897.2CHD7, GLI2, GLI3, LPP, MYCN, NOG
17MP:00053887.0CHD7, FOXF1, GLI2, GLI3, MYCN, NOG
18MP:00107686.6CHD7, FOXF1, GLI2, GLI3, LPP, MYCN

Publications for Esophageal Atresia

About this section

Articles related to Esophageal Atresia:

(show top 50)    (show all 648)
idTitleAuthorsYear
1
EVALUATION OF RISK FACTORS AFFECTING ANASTOMOTIC LEAKAGE AFTER REPAIR OF ESOPHAGEAL ATRESIA. (26537137)
2015
2
A cross-sectional nationwide survey on esophageal atresia and tracheoesophageal fistula. (25783403)
2015
3
Physiological Studies at 7 Years of Age in Children Born with Esophageal Atresia. (25302538)
2014
4
Thoracoscopic repair of esophageal atresia with tracheoesophageal fistula: overcoming the learning curve. (25475795)
2014
5
Efficacy and histopathological esophageal wall damage of biodegradable esophageal stents for treatment of severe refractory esophageal anastomotic stricture in a child with long gap esophageal atresia. (25399341)
2014
6
The diagnosis of fetal esophageal atresia and its implications on perinatal outcome. (25056797)
2014
7
Esophageal atresia, small omphalocele and ileal prolapse through a patent omphalomesenteric duct: a methamizole embryopathy? (23845657)
2013
8
Long-gap esophageal atresia: traction-growth and anastomosis - before and beyond. (23679026)
2013
9
VACTERL (Vertebral Defects, Anal Atresia, Tracheoesophageal Fistula withA Esophageal Atresia, Cardiac Defects, Renal and Limb Anomalies) Association: Disease Spectrum in 25 Patients Ascertained for Their UpperA Limb Involvement. (24210691)
2013
10
Operative intercostal chest drain is not required following extrapleural or transpleural esophageal atresia repair. (23172565)
2013
11
Minimally invasive repair of esophageal atresia: an update. (23720207)
2013
12
A case series study of therapeutic implications of type IIIb4: a rare variant of esophageal atresia and distal tracheoesophageal fistula. (23895955)
2013
13
Mortality in esophageal atresia: Assessment of probable risk factors (10 years' experience). (23626630)
2012
14
A simple technique of oblique anastomosis can prevent stricture formation in primary repair of esophageal atresia. (22974622)
2012
15
Comparison of neonatal tolerance to thoracoscopic and open repair of esophageal atresia with tracheoesophageal fistula. (23044311)
2012
16
Re: Novel use of glycopyrrolate (Robinul) in the treatment of anastomotic leak after repair of esophageal atresia and trachea-esophageal fistula. (23084219)
2012
17
Contribution of LPP copy number and sequence changes to esophageal atresia, tracheoesophageal fistula, and VACTERL association. (22639458)
2012
18
A pilot study of laparoscopic gastric pull-up by using the natural orifice translumenal endoscopic surgery technique: a novel procedure for treating long-gap esophageal atresia (type a). (21859341)
2011
19
Increased incidence of esophageal atresia in northwest Tuscany: years 1994-2007. (21487371)
2011
20
Complete vs partial fundoplication in children with esophageal atresia. (21616240)
2011
21
Pre- and postnatal diagnosis and outcome of fetuses and neonates with esophageal atresia and tracheoesophageal fistula. (20112230)
2010
22
Esophageal atresia/tracheoesophageal fistula complicated by hypertrophic pyloric stenosis: a case report. (20113643)
2010
23
Diagnosis of esophageal atresia with tracheoesophageal fistula: is there a need for gastrointestinal contrast? (20056230)
2010
24
Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia. (20054858)
2010
25
Esophageal atresia/tracheoesophageal fistula in very low-birth-weight neonates: improved outcomes with staged repair. (20006009)
2009
26
The right-sided aortic arch in children with esophageal atresia and tracheo-esophageal fistula: a repair through the right thoracotomy. (19308429)
2009
27
Thoracoscopic repair of congenital esophageal atresia in infants. (19243269)
2009
28
The pitfalls of endotracheal intubation beyond the fistula in babies with type C esophageal atresia. (19349003)
2009
29
Longitudinal follow-up of bronchial inflammation, respiratory symptoms, and pulmonary function in adolescents after repair of esophageal atresia with tracheoesophageal fistula. (18534205)
2008
30
Long gap esophageal atresia and arterial circle of Willis variant leading to ischemic stroke during gastric transposition. (18437659)
2008
31
Respiratory and gastrointestinal symptoms in esophageal atresia. (19490655)
2008
32
MCRA of an anastomotic stenosis after esophagoesophagostomy for long gap esophageal atresia: a case report. (17502180)
2007
33
VACTERL anomalies in patients with esophageal atresia: an updated delineation of the spectrum and review of the literature. (17377826)
2007
34
Iatrogenic esophageal perforation that may sometimes masquerade as esophageal atresia. (15856590)
2005
35
Esophageal atresia with double tracheoesophageal fistula--a case report and review of the literature. (16254849)
2005
36
Reflux in esophageal atresia, tracheoesophageal cleft, and esophagocoloplasty: Bianchi's procedure as an alternative approach. (15852275)
2005
37
Absence of deletion at the SOX2 locus in a case of microphthalmia and esophageal atresia. (15487011)
2004
38
&quot;Thoracic gastrostomy&quot;--a new technique for feeding gastrostomy in wide-gap esophageal atresia and tracheo-esophageal fistula. (14551716)
2003
39
Lengthening technique for long gap esophageal atresia and early anastomosis. (12720183)
2003
40
The distal pouch in esophageal atresia -- to dissect or not to dissect, that is the question. (11967754)
2002
41
Esophageal atresia associated with tracheal stenosis and right lung agenesis: report of one case. (12632790)
2002
42
Wide-gap esophageal atresia. (11727069)
2001
43
Elective, postoperative ventilation in the management of esophageal atresia and tracheoesophageal fistula. (9099641)
1997
44
Abnormalities of neuropeptides and neural markers in the esophagus of fetal rats with adriamycin-induced esophageal atresia. (9349759)
1997
45
Coexisting left congenital diaphragmatic hernia and esophageal atresia with tracheoesophageal fistula: successful management in a premature neonate. (8811578)
1996
46
Simple technique for proximal pouch mobilization and circular myotomy in cases of esophageal atresia with tracheoesophageal fistula. (7807338)
1994
47
Esophageal atresia and tracheoesophageal fistula in children. (8374655)
1993
48
Maturational dysautonomia and facial anomalies associated with esophageal atresia: support for neural crest involvement. (8331506)
1993
49
Esophageal Atresia/Tracheoesophageal Fistula Overview (20301753)
1993
50
Esophageal atresia, coloboma, and clubfoot in two unrelated infants. (6469248)
1984

Variations for Esophageal Atresia

About this section

Expression for genes affiliated with Esophageal Atresia

About this section
Search GEO for disease gene expression data for Esophageal Atresia.

Pathways for genes affiliated with Esophageal Atresia

About this section

Pathways related to Esophageal Atresia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7GLI2, SHH
29.4GLI2, SHH, SOX2
3
Show member pathways
9.2GLI2, GLI3, SHH
49.2GLI2, GLI3, SHH
5
Show member pathways
9.2GLI2, GLI3, SHH

GO Terms for genes affiliated with Esophageal Atresia

About this section

Cellular components related to Esophageal Atresia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ciliary baseGO:009754610.2GLI2, GLI3
2ciliary tipGO:009754210.2GLI2, GLI3
3nuclear speckGO:00166079.2EFTUD2, GLI2, GLI3
4nucleusGO:00056346.3CHD7, EFTUD2, FOXF1, GLI2, GLI3, LPP

Biological processes related to Esophageal Atresia according to GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idNameGO IDScoreTop Affiliating Genes
1somite developmentGO:006105310.5NOG, SHH
2negative regulation of alpha-beta T cell differentiationGO:004663910.5GLI3, SHH
3prostatic bud formationGO:006051310.4GLI2, NOG
4respiratory tube developmentGO:003032310.4FOXF1, SHH
5embryonic foregut morphogenesisGO:004861710.4FOXF1, SHH
6trachea developmentGO:006043810.4FOXF1, SHH
7lung lobe morphogenesisGO:006046310.4FOXF1, SHH
8positive regulation of alpha-beta T cell differentiationGO:004663810.4GLI3, SHH
9ventral midline developmentGO:000741810.4GLI2, SHH
10smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:002193810.4GLI2, SHH
11artery developmentGO:006084010.3GLI3, SHH
12negative thymic T cell selectionGO:004506010.3GLI3, SHH
13positive regulation of T cell differentiation in thymusGO:003308910.3GLI2, SHH
14spinal cord dorsal/ventral patterningGO:002151310.2GLI2, GLI3
15smoothened signaling pathway involved in ventral spinal cord interneuron specificationGO:002177510.2GLI2, GLI3
16smoothened signaling pathway involved in spinal cord motor neuron cell fate specificationGO:002177610.2GLI2, GLI3
17tube developmentGO:003529510.2GLI2, GLI3
18smoothened signaling pathway involved in dorsal/ventral neural tube patterningGO:006083110.2GLI2, GLI3
19lung morphogenesisGO:006042510.0FOXF1, NOG, SHH
20negative regulation of cell differentiationGO:004559610.0GLI3, NOG, SHH
21hindgut morphogenesisGO:00074429.9GLI2, GLI3, SHH
22embryonic digestive tract morphogenesisGO:00485579.9FOXF1, GLI3, SHH
23pituitary gland developmentGO:00219839.9GLI2, NOG, SOX2
24neural tube developmentGO:00219159.9GLI2, GLI3, NOG
25camera-type eye developmentGO:00430109.8CHD7, GLI3, SHH
26anatomical structure developmentGO:00488569.8GLI2, GLI3, SHH
27branching morphogenesis of an epithelial tubeGO:00487549.8GLI2, GLI3, SHH
28osteoblast differentiationGO:00016499.8GLI2, NOG, SOX2
29spinal cord motor neuron differentiationGO:00215229.8GLI2, GLI3, SHH
30developmental growthGO:00485899.7GLI2, GLI3, SHH
31limb developmentGO:00601739.6CHD7, GLI3, NOG, SHH
32odontogenesis of dentin-containing toothGO:00424759.6GLI2, GLI3, SHH
33inner ear developmentGO:00488399.6GLI3, SHH, SOX2
34dorsal/ventral pattern formationGO:00099539.6GLI2, GLI3, NOG, SHH
35forebrain developmentGO:00309009.5GLI3, NOG, SHH, SOX2
36negative regulation of canonical Wnt signaling pathwayGO:00900909.5GLI3, NOG, SHH, SOX2
37anatomical structure formation involved in morphogenesisGO:00486469.5GLI2, GLI3, NOG, SHH
38embryonic digestive tract developmentGO:00485669.5FOXF1, GLI2, GLI3
39pattern specification processGO:00073899.5GLI2, GLI3, NOG, SHH
40palate developmentGO:00600219.5CHD7, GLI3, SHH
41embryonic digit morphogenesisGO:00427339.5GLI2, GLI3, NOG, SHH
42smoothened signaling pathwayGO:00072249.4FOXF1, GLI2, GLI3, SHH
43central nervous system developmentGO:00074179.3CHD7, GLI3, NOG, SHH
44lung developmentGO:00303249.1FOXF1, GLI2, GLI3, SHH
45in utero embryonic developmentGO:00017018.9CHD7, FOXF1, GLI2, GLI3, NOG
46skeletal system developmentGO:00015018.7CHD7, GLI2, NOG, TCOF1
47heart developmentGO:00075078.7FOXF1, GLI2, GLI3, SHH
48positive regulation of transcription, DNA-templatedGO:00458938.5FOXF1, GLI2, GLI3, MYCN, SHH, SOX2
49positive regulation of transcription from RNA polymerase II promoterGO:00459448.2FOXF1, GLI2, GLI3, NOG, SHH, SOX2
50negative regulation of transcription from RNA polymerase II promoterGO:00001227.9FOXF1, GLI2, GLI3, NOG, SHH, SOX2

Molecular functions related to Esophageal Atresia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010779.7GLI2, GLI3, SOX2
2transcription regulatory region DNA bindingGO:00442129.4FOXF1, GLI2, SOX2
3sequence-specific DNA bindingGO:00435658.8FOXF1, GLI2, GLI3, SOX2
4transcription factor activity, sequence-specific DNA bindingGO:00037008.1FOXF1, GLI2, GLI3, MYCN, SOX2

Sources for Esophageal Atresia

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet