MCID: ESP010
MIFTS: 36

Esophageal Basaloid Squamous Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards integrated aliases for Esophageal Basaloid Squamous Cell Carcinoma:

Name: Esophageal Basaloid Squamous Cell Carcinoma 12 14
Basaloid Squamous Carcinoma of Esophagus 12
Esophageal Basaloid Carcinoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7051
NCIt 46 C7032
UMLS 69 C1333443

Summaries for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards based summary : Esophageal Basaloid Squamous Cell Carcinoma, also known as basaloid squamous carcinoma of esophagus, is related to basaloid squamous cell carcinoma and brain ependymoma, and has symptoms including regurgitation and pain. An important gene associated with Esophageal Basaloid Squamous Cell Carcinoma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are Signaling by GPCR and Endometrial cancer. Affiliated tissues include neutrophil, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Esophageal Basaloid Squamous Cell Carcinoma

Diseases related to Esophageal Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 basaloid squamous cell carcinoma 31.1 EGFR KRT14 TP53
2 brain ependymoma 10.5 EGFR TP53
3 mucoepidermoid esophageal carcinoma 10.5 TP53 WWOX
4 squamous cell carcinoma of the larynx 10.4 EGFR TP53
5 benign breast adenomyoepithelioma 10.4 EGFR KRT14
6 esophagitis 10.4
7 squamous cell carcinoma 10.4
8 brain stem glioma 10.4 EGFR TP53
9 oncocytic breast carcinoma 10.4 EGFR KRT14
10 female reproductive endometrioid cancer 10.4 CTNNB1 TP53
11 lymph node cancer 10.4 TP53 WWOX
12 microglandular adenosis 10.3 EGFR TP53
13 breast squamous cell carcinoma 10.3 EGFR KRT14
14 pulmonary blastoma 10.3 EGFR TP53
15 hair follicle neoplasm 10.3 CTNNB1 KRT14
16 breast metaplastic carcinoma 10.3 EGFR KRT14 TP53
17 pre-malignant neoplasm 10.3 EGFR KRT14 TP53
18 in situ carcinoma 10.3 EGFR KRT14 TP53
19 ductal carcinoma in situ 10.3 EGFR KRT14 TP53
20 uterine carcinosarcoma 10.3 CTNNB1 EGFR TP53
21 pleomorphic carcinoma 10.3 EGFR TP53
22 cervical squamous cell carcinoma 10.3 CTNNB1 EGFR TP53
23 central nervous system organ benign neoplasm 10.3 CTNNB1 TP53
24 endometrial adenocarcinoma 10.2 CTNNB1 EGFR TP53
25 pancreas adenocarcinoma 10.2 CTNNB1 EGFR TP53
26 colorectal adenocarcinoma 10.2 CTNNB1 EGFR TP53
27 ovarian cancer 1 10.2 CTNNB1 EGFR TP53
28 female reproductive organ cancer 10.2 CTNNB1 EGFR TP53
29 intrahepatic cholangiocarcinoma 10.2 CTNNB1 EGFR TP53
30 squamous cell papilloma 10.2 SFRP4 TP53 WWOX
31 reproductive organ cancer 10.2 CTNNB1 EGFR TP53
32 pancreatic ductal adenocarcinoma 10.2 CTNNB1 EGFR TP53
33 breast ductal carcinoma 10.2 CTNNB1 EGFR TP53
34 oral squamous cell carcinoma 10.2 CTNNB1 EGFR TP53
35 brain cancer 10.2 CTNNB1 EGFR TP53
36 breast benign neoplasm 10.2 KRT14 TP53
37 thoracic benign neoplasm 10.1 KRT14 TP53
38 gastrointestinal system cancer 10.1 CTNNB1 EGFR TP53 WWOX
39 cell type cancer 10.1 CTNNB1 EGFR TP53 WWOX
40 adult hepatocellular carcinoma 10.0 AXIN1 CTNNB1 TP53
41 embryonal sarcoma 10.0 AXIN1 CTNNB1 TP53
42 esophageal cancer 9.9 CTNNB1 EGFR TP53 WWOX
43 familial adenomatous polyposis 9.6 AXIN1 AXIN2 CTNNB1 TP53
44 adenoma 9.5 AXIN2 CTNNB1 TP53

Graphical network of the top 20 diseases related to Esophageal Basaloid Squamous Cell Carcinoma:



Diseases related to Esophageal Basaloid Squamous Cell Carcinoma

Symptoms & Phenotypes for Esophageal Basaloid Squamous Cell Carcinoma

UMLS symptoms related to Esophageal Basaloid Squamous Cell Carcinoma:


regurgitation, pain

MGI Mouse Phenotypes related to Esophageal Basaloid Squamous Cell Carcinoma:

43 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.29 DACT1 EGFR KRT14 SFRP1 SFRP2 SFRP4
2 mortality/aging MP:0010768 10.27 AXIN1 AXIN2 CTNNB1 DACT1 EGFR KRT14
3 cardiovascular system MP:0005385 10.22 AXIN1 AXIN2 CTNNB1 DACT1 EGFR SFRP1
4 limbs/digits/tail MP:0005371 10.22 AXIN1 AXIN2 CTNNB1 DACT1 EGFR FRZB
5 embryo MP:0005380 10.19 AXIN1 AXIN2 CTNNB1 DACT1 EGFR SFRP1
6 endocrine/exocrine gland MP:0005379 10.18 AXIN2 CTNNB1 EGFR KRT14 SFRP1 SFRP2
7 craniofacial MP:0005382 10.16 AXIN1 AXIN2 CTNNB1 EGFR KRT14 SFRP1
8 nervous system MP:0003631 10.14 SFRP5 TP53 WWOX AXIN1 AXIN2 CTNNB1
9 digestive/alimentary MP:0005381 10.09 AXIN1 CTNNB1 DACT1 EGFR KRT14 SFRP4
10 no phenotypic analysis MP:0003012 9.97 AXIN2 CTNNB1 DACT1 EGFR SFRP1 SFRP2
11 reproductive system MP:0005389 9.93 WWOX AXIN1 AXIN2 CTNNB1 DACT1 EGFR
12 normal MP:0002873 9.92 AXIN1 AXIN2 CTNNB1 EGFR FRZB SFRP2
13 neoplasm MP:0002006 9.91 CTNNB1 EGFR KRT14 TP53 WIF1 WWOX
14 hearing/vestibular/ear MP:0005377 9.89 CTNNB1 EGFR KRT14 TP53 AXIN1
15 renal/urinary system MP:0005367 9.73 AXIN1 CTNNB1 DACT1 EGFR SFRP4 TP53
16 respiratory system MP:0005388 9.43 AXIN1 CTNNB1 EGFR KRT14 SFRP4 TP53
17 skeleton MP:0005390 9.36 AXIN1 AXIN2 CTNNB1 DACT1 EGFR FRZB

Drugs & Therapeutics for Esophageal Basaloid Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Esophageal Basaloid Squamous Cell Carcinoma

Genetic Tests for Esophageal Basaloid Squamous Cell Carcinoma

Anatomical Context for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards organs/tissues related to Esophageal Basaloid Squamous Cell Carcinoma:

38
Neutrophil

Publications for Esophageal Basaloid Squamous Cell Carcinoma

Articles related to Esophageal Basaloid Squamous Cell Carcinoma:

# Title Authors Year
1
A long-surviving patient with advanced esophageal basaloid squamous cell carcinoma treated only with radiotherapy: case report and literature review. ( 29216832 )
2017
2
The Preoperative Neutrophil-To-Lymphocyte Ratio Is a Novel Immune Parameter for the Prognosis of Esophageal Basaloid Squamous Cell Carcinoma. ( 27959959 )
2016
3
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma. ( 26045734 )
2015
4
Downregulation of sFRP-2 by epigenetic silencing activates the I^-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. ( 24464051 )
2014
5
Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas. ( 22607702 )
2012
6
An isolated digital metastasis of esophageal basaloid squamous cell carcinoma. ( 10885705 )
2000

Variations for Esophageal Basaloid Squamous Cell Carcinoma

Expression for Esophageal Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophageal Basaloid Squamous Cell Carcinoma.

Pathways for Esophageal Basaloid Squamous Cell Carcinoma

Pathways related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 AXIN1 AXIN2 CTNNB1 DACT1 EGFR SFRP1
2
Show member pathways
12.9 AXIN1 AXIN2 CTNNB1 EGFR TP53
3
Show member pathways
12.83 AXIN1 AXIN2 CTNNB1 EGFR TP53
4 12.7 AXIN1 AXIN2 CTNNB1 EGFR TP53
5
Show member pathways
12.61 AXIN1 AXIN2 CTNNB1 EGFR TP53
6
Show member pathways
12.46 AXIN1 AXIN2 CTNNB1 DACT1 SFRP1 SFRP2
7
Show member pathways
12.37 AXIN1 AXIN2 CTNNB1 SFRP1
8
Show member pathways
12.35 AXIN1 AXIN2 EGFR TP53
9 12.23 AXIN1 CTNNB1 FRZB TP53 WIF1
10
Show member pathways
12.22 AXIN1 AXIN2 CTNNB1 TP53
11
Show member pathways
12.12 AXIN1 AXIN2 CTNNB1 SFRP1 SFRP2 SFRP4
12 12.03 AXIN2 CTNNB1 EGFR TP53
13 12.01 AXIN1 AXIN2 CTNNB1
14 12.01 CTNNB1 EGFR TP53
15 11.96 AXIN1 AXIN2 CTNNB1
16 11.92 CTNNB1 FRZB SFRP4
17 11.91 AXIN1 AXIN2 CTNNB1 SFRP1 WIF1
18 11.85 AXIN1 CTNNB1 TP53
19 11.8 AXIN1 CTNNB1 EGFR TP53
20 11.79 AXIN1 AXIN2 CTNNB1
21 11.58 AXIN1 CTNNB1 EGFR
22
Show member pathways
11.51 AXIN1 AXIN2 CTNNB1 FRZB SFRP1 SFRP2
23 11.44 AXIN1 AXIN2 CTNNB1
24 11.36 AXIN1 CTNNB1 WIF1
25 11.19 CTNNB1 EGFR TP53
26 11.13 AXIN1 CTNNB1 EGFR
27 10.96 AXIN2 CTNNB1 WIF1
28
Show member pathways
10.87 SFRP1 SFRP2 WIF1
29 10.75 AXIN1 CTNNB1 SFRP4
30 10.71 CTNNB1 SFRP1

GO Terms for Esophageal Basaloid Squamous Cell Carcinoma

Cellular components related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 9.13 AXIN1 CTNNB1 KRT14
2 beta-catenin destruction complex GO:0030877 8.92 AXIN1 AXIN2 CTNNB1 DACT1

Biological processes related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.98 AXIN2 CTNNB1 EGFR TP53
2 response to drug GO:0042493 9.96 CTNNB1 SFRP1 SFRP2 TP53
3 positive regulation of apoptotic process GO:0043065 9.95 CTNNB1 FRZB SFRP1 SFRP2 SFRP4 TP53
4 negative regulation of cell proliferation GO:0008285 9.92 AXIN2 CTNNB1 FRZB SFRP1 SFRP2 SFRP4
5 response to organic cyclic compound GO:0014070 9.85 EGFR SFRP1 TP53
6 negative regulation of cell growth GO:0030308 9.84 FRZB SFRP1 SFRP2 TP53
7 positive regulation of canonical Wnt signaling pathway GO:0090263 9.83 AXIN1 AXIN2 SFRP1 SFRP2 SFRP4
8 canonical Wnt signaling pathway GO:0060070 9.81 AXIN1 CTNNB1 SFRP1
9 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.8 AXIN1 EGFR SFRP2
10 positive regulation of cell growth GO:0030307 9.8 EGFR SFRP1 SFRP2
11 cellular response to growth factor stimulus GO:0071363 9.79 CTNNB1 EGFR SFRP1
12 somitogenesis GO:0001756 9.78 AXIN2 SFRP1 SFRP2
13 neural tube development GO:0021915 9.77 DACT1 SFRP1 SFRP2
14 positive regulation of fat cell differentiation GO:0045600 9.76 FRZB SFRP1 SFRP2 WIF1
15 negative regulation of canonical Wnt signaling pathway GO:0090090 9.76 AXIN1 AXIN2 DACT1 FRZB SFRP1 SFRP2
16 regulation of Wnt signaling pathway GO:0030111 9.71 AXIN1 AXIN2 SFRP2 SFRP5
17 Wnt signaling pathway GO:0016055 9.7 AXIN1 AXIN2 CTNNB1 DACT1 FRZB SFRP1
18 digestive tract morphogenesis GO:0048546 9.69 EGFR SFRP1 SFRP2
19 negative regulation of osteoclast differentiation GO:0045671 9.68 CTNNB1 SFRP1
20 beta-catenin destruction complex disassembly GO:1904886 9.68 AXIN1 CTNNB1
21 negative regulation of JUN kinase activity GO:0043508 9.67 SFRP1 SFRP2
22 positive regulation of catenin import into nucleus GO:0035413 9.67 DACT1 EGFR SFRP2
23 non-canonical Wnt signaling pathway GO:0035567 9.67 FRZB SFRP2 SFRP4 SFRP5
24 planar cell polarity pathway involved in neural tube closure GO:0090179 9.66 SFRP1 SFRP2
25 negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 9.65 SFRP1 SFRP2
26 negative regulation of catenin import into nucleus GO:0035414 9.65 AXIN2 SFRP5
27 cellular response to X-ray GO:0071481 9.65 SFRP1 SFRP2
28 regulation of BMP signaling pathway GO:0030510 9.64 SFRP4 SFRP5
29 dorsal/ventral axis specification GO:0009950 9.62 CTNNB1 SFRP1
30 Wnt signaling pathway involved in somitogenesis GO:0090244 9.59 SFRP1 SFRP2
31 development of primary male sexual characteristics GO:0046546 9.58 SFRP1 SFRP2
32 regulation of establishment of planar polarity GO:0090175 9.58 SFRP1 SFRP2
33 regulation of centromeric sister chromatid cohesion GO:0070602 9.57 AXIN2 CTNNB1
34 regulation of midbrain dopaminergic neuron differentiation GO:1904956 9.56 SFRP1 SFRP2
35 negative regulation of planar cell polarity pathway involved in axis elongation GO:2000041 9.55 SFRP1 SFRP2
36 negative regulation of Wnt signaling pathway GO:0030178 9.28 AXIN1 DACT1 FRZB SFRP1 SFRP2 SFRP4
37 cell differentiation GO:0030154 10.07 CTNNB1 FRZB SFRP1 SFRP2 SFRP4 SFRP5
38 apoptotic process GO:0006915 10.06 AXIN1 SFRP2 SFRP5 TP53 WWOX
39 positive regulation of transcription, DNA-templated GO:0045893 10.04 AXIN1 CTNNB1 EGFR SFRP1 TP53
40 multicellular organism development GO:0007275 10 AXIN1 AXIN2 DACT1 EGFR FRZB SFRP1

Molecular functions related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.85 FRZB SFRP1 SFRP2 SFRP4 SFRP5
2 protein kinase binding GO:0019901 9.78 AXIN1 CTNNB1 EGFR TP53
3 ubiquitin protein ligase binding GO:0031625 9.73 AXIN1 AXIN2 EGFR TP53
4 enzyme binding GO:0019899 9.63 AXIN1 AXIN2 CTNNB1 EGFR TP53 WWOX
5 beta-catenin binding GO:0008013 9.58 AXIN1 AXIN2 DACT1
6 protein phosphatase binding GO:0019903 9.54 CTNNB1 EGFR TP53
7 RNA polymerase II transcription factor binding GO:0001085 9.5 CTNNB1 DACT1 TP53
8 I-SMAD binding GO:0070411 9.43 AXIN1 AXIN2 CTNNB1
9 Wnt-activated receptor activity GO:0042813 9.35 FRZB SFRP1 SFRP2 SFRP4 SFRP5
10 Wnt-protein binding GO:0017147 9.1 FRZB SFRP1 SFRP2 SFRP4 SFRP5 WIF1

Sources for Esophageal Basaloid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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