MCID: ESP010
MIFTS: 34

Esophageal Basaloid Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards integrated aliases for Esophageal Basaloid Squamous Cell Carcinoma:

Name: Esophageal Basaloid Squamous Cell Carcinoma 12 14
Basaloid Squamous Carcinoma of Esophagus 12
Esophageal Basaloid Carcinoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:7051
NCIt 47 C7032
UMLS 69 C1333443

Summaries for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards based summary : Esophageal Basaloid Squamous Cell Carcinoma, also known as basaloid squamous carcinoma of esophagus, is related to pediatric infratentorial ependymoma and deep angioma, and has symptoms including pain and regurgitation. An important gene associated with Esophageal Basaloid Squamous Cell Carcinoma is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are Signaling by GPCR and PI3K-Akt signaling pathway. Affiliated tissues include neutrophil, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Esophageal Basaloid Squamous Cell Carcinoma

Diseases related to Esophageal Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
id Related Disease Score Top Affiliating Genes
1 pediatric infratentorial ependymoma 10.8 EGFR TP53
2 deep angioma 10.7 TP53 WWOX
3 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.6 EGFR TP53
4 gastric tubular adenocarcinoma 10.6 EGFR KRT14
5 breast myoepithelial neoplasm 10.6 CTNNB1 TP53
6 middle ear squamous cell carcinoma 10.5 EGFR KRT14 TP53
7 lacrimal gland mucoepidermoid carcinoma 10.5 EGFR KRT14 TP53
8 ductal carcinoma in situ 10.5 EGFR KRT14 TP53
9 anaerobic pneumonia 10.5 EGFR KRT14 TP53
10 childhood infratentorial neoplasm 10.5 EGFR TP53
11 rectum kaposi's sarcoma 10.5 CTNNB1 EGFR TP53
12 pancreatic somatostatinoma 10.5 CTNNB1 EGFR TP53
13 estrogen-receptor negative breast cancer 10.5 EGFR KRT14 TP53
14 endometriosis of uterus 10.5 CTNNB1 EGFR TP53
15 nominal aphasia 10.5 EGFR KRT14 TP53
16 arteritic anterior ischemic optic neuropathy 10.5 CTNNB1 EGFR TP53
17 hemoglobin e disease 10.5 CTNNB1 KRT14
18 molluscum contagiosum 10.5 EGFR TP53 WWOX
19 trachea squamous cell carcinoma 10.5 CTNNB1 EGFR TP53
20 apocrine adenocarcinoma 10.4 CTNNB1 EGFR TP53
21 paroxysmal nocturnal hemoglobinuria 10.4 CTNNB1 EGFR TP53
22 bardet-biedl syndrome 10.4 CTNNB1 EGFR TP53
23 penis squamous cell carcinoma 10.4 EGFR KRT14
24 breast granular cell tumor 10.4 CTNNB1 EGFR TP53
25 nail disorder, nonsyndromic congenital, 1 10.4 CTNNB1 EGFR TP53
26 villous adenoma 10.4 CTNNB1 EGFR TP53
27 breast fibrosarcoma 10.4 EGFR TP53
28 acute porphyria 10.4 CTNNB1 EGFR TP53
29 red color blindness 10.4 SFRP4 TP53 WWOX
30 nodular goiter 10.3 CTNNB1 EGFR TP53
31 gastric cancer, somatic 10.3 CTNNB1 EGFR TP53
32 autonomic nervous system neoplasm 10.3 EGFR KRT14 TP53
33 esophagitis 10.3
34 squamous cell carcinoma 10.3
35 basaloid squamous cell carcinoma 10.3
36 glycogen storage disease due to lactate dehydrogenase deficiency 10.2 AXIN1 CTNNB1 TP53
37 enamel hypoplasia cataract hydrocephaly 10.2 AXIN1 CTNNB1 TP53
38 gallbladder cancer 10.2 CTNNB1 EGFR TP53 WWOX
39 primary optic atrophy 10.2 TP53 WWOX
40 brown-vialetto-van laere syndrome 10.2 CTNNB1 EGFR TP53 WWOX
41 hartnup disorder 10.1 CTNNB1 EGFR TP53
42 trichoepithelioma, multiple familial, 1 10.0 KRT14 TP53
43 desmoid disease, hereditary 10.0 AXIN1 AXIN2 CTNNB1
44 nail disorder, nonsyndromic congenital, 3, 9.9 CTNNB1 EGFR TP53 WWOX
45 arrhythmogenic right ventricular cardiomyopathy 9.8 AXIN1 AXIN2 CTNNB1 TP53
46 glioblastoma 3 9.3 AXIN1 CTNNB1 DKK1 TP53
47 spinal cord dermoid cyst 5.3 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR

Graphical network of the top 20 diseases related to Esophageal Basaloid Squamous Cell Carcinoma:



Diseases related to Esophageal Basaloid Squamous Cell Carcinoma

Symptoms & Phenotypes for Esophageal Basaloid Squamous Cell Carcinoma

UMLS symptoms related to Esophageal Basaloid Squamous Cell Carcinoma:


pain, regurgitation

MGI Mouse Phenotypes related to Esophageal Basaloid Squamous Cell Carcinoma:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.32 KRT14 SFRP1 SFRP2 SFRP4 SFRP5 TP53
2 mortality/aging MP:0010768 10.3 SFRP1 SFRP2 SFRP4 SFRP5 TP53 WIF1
3 limbs/digits/tail MP:0005371 10.26 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR
4 embryo MP:0005380 10.24 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR
5 cardiovascular system MP:0005385 10.23 EGFR SFRP1 SFRP2 SFRP4 TP53 AXIN1
6 cellular MP:0005384 10.22 AXIN1 AXIN2 CTNNB1 DKK1 EGFR KRT14
7 craniofacial MP:0005382 10.21 AXIN1 AXIN2 CTNNB1 DKK1 EGFR KRT14
8 homeostasis/metabolism MP:0005376 10.19 KRT14 SFRP1 SFRP2 SFRP4 TP53 WWOX
9 endocrine/exocrine gland MP:0005379 10.18 AXIN2 CTNNB1 EGFR KRT14 SFRP1 SFRP2
10 nervous system MP:0003631 10.18 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR
11 digestive/alimentary MP:0005381 10.09 AXIN1 CTNNB1 DACT1 EGFR KRT14 SFRP4
12 no phenotypic analysis MP:0003012 9.97 AXIN2 CTNNB1 DACT1 EGFR SFRP1 SFRP2
13 reproductive system MP:0005389 9.93 CTNNB1 DACT1 EGFR KRT14 SFRP1 SFRP2
14 normal MP:0002873 9.92 AXIN1 AXIN2 CTNNB1 EGFR FRZB SFRP2
15 neoplasm MP:0002006 9.91 EGFR KRT14 TP53 WIF1 WWOX CTNNB1
16 renal/urinary system MP:0005367 9.8 AXIN1 CTNNB1 DACT1 DKK1 EGFR SFRP4
17 respiratory system MP:0005388 9.5 AXIN1 CTNNB1 DKK1 EGFR KRT14 SFRP4
18 skeleton MP:0005390 9.4 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR

Drugs & Therapeutics for Esophageal Basaloid Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Esophageal Basaloid Squamous Cell Carcinoma

Genetic Tests for Esophageal Basaloid Squamous Cell Carcinoma

Anatomical Context for Esophageal Basaloid Squamous Cell Carcinoma

MalaCards organs/tissues related to Esophageal Basaloid Squamous Cell Carcinoma:

39
Neutrophil

Publications for Esophageal Basaloid Squamous Cell Carcinoma

Articles related to Esophageal Basaloid Squamous Cell Carcinoma:

id Title Authors Year
1
The Preoperative Neutrophil-To-Lymphocyte Ratio Is a Novel Immune Parameter for the Prognosis of Esophageal Basaloid Squamous Cell Carcinoma. ( 27959959 )
2016
2
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma. ( 26045734 )
2015
3
Downregulation of sFRP-2 by epigenetic silencing activates the I^-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. ( 24464051 )
2014
4
Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas. ( 22607702 )
2012
5
An isolated digital metastasis of esophageal basaloid squamous cell carcinoma. ( 10885705 )
2000

Variations for Esophageal Basaloid Squamous Cell Carcinoma

Expression for Esophageal Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophageal Basaloid Squamous Cell Carcinoma.

Pathways for Esophageal Basaloid Squamous Cell Carcinoma

Pathways related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 EGFR
2 12.55 AXIN1 AXIN2 CTNNB1 EGFR TP53
3 12.55 AXIN1 AXIN2 CTNNB1 EGFR TP53
4
Show member pathways
12.52 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 SFRP1
5
Show member pathways
12.4 AXIN1 AXIN2 CTNNB1 DKK1 SFRP1
6
Show member pathways
12.37 AXIN1 AXIN2 EGFR TP53
7 12.28 AXIN1 CTNNB1 DKK1 FRZB TP53 WIF1
8
Show member pathways
12.24 AXIN1 AXIN2 CTNNB1 TP53
9
Show member pathways
12.16 AXIN1 AXIN2 CTNNB1 DKK1 SFRP1 SFRP2
10 12.07 AXIN2 CTNNB1 EGFR TP53
11 12.06 AXIN1 AXIN2 CTNNB1 DKK1 SFRP1 WIF1
12 11.96 AXIN1 AXIN2 CTNNB1
13 11.93 CTNNB1 FRZB SFRP4
14 11.92 DKK1 EGFR TP53
15 11.86 AXIN1 CTNNB1 TP53
16 11.84 AXIN1 CTNNB1 EGFR TP53
17 11.8 AXIN1 AXIN2 CTNNB1
18 11.67 AXIN2 CTNNB1 DKK1
19 11.58 AXIN1 CTNNB1 EGFR
20
Show member pathways
11.55 AXIN1 AXIN2 CTNNB1 DKK1 FRZB SFRP1
21 11.47 AXIN1 AXIN2 CTNNB1
22 11.4 AXIN1 CTNNB1 DKK1 WIF1
23 11.23 CTNNB1 EGFR TP53
24 11.16 AXIN1 CTNNB1 EGFR
25 11.05 AXIN2 CTNNB1 DKK1 WIF1
26 10.91 AXIN1 CTNNB1 SFRP4
27
Show member pathways
10.88 DKK1 SFRP1 SFRP2 WIF1
28 10.75 CTNNB1 DKK1 SFRP1

GO Terms for Esophageal Basaloid Squamous Cell Carcinoma

Cellular components related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 DKK1 EGFR FRZB SFRP1 SFRP2 SFRP4
2 extracellular region GO:0005576 9.7 DKK1 EGFR FRZB SFRP1 SFRP2 SFRP4
3 cell periphery GO:0071944 9.13 AXIN1 CTNNB1 KRT14
4 beta-catenin destruction complex GO:0030877 8.92 AXIN1 AXIN2 CTNNB1 DACT1

Biological processes related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 44)
id Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.98 AXIN2 CTNNB1 EGFR TP53
2 positive regulation of gene expression GO:0010628 9.98 CTNNB1 DKK1 SFRP4 TP53
3 positive regulation of apoptotic process GO:0043065 9.97 CTNNB1 FRZB SFRP1 SFRP2 SFRP4 TP53
4 negative regulation of cell proliferation GO:0008285 9.97 AXIN2 CTNNB1 FRZB SFRP1 SFRP2 SFRP4
5 negative regulation of cell growth GO:0030308 9.86 FRZB SFRP1 SFRP2 TP53
6 positive regulation of canonical Wnt signaling pathway GO:0090263 9.83 AXIN1 AXIN2 SFRP1 SFRP2 SFRP4
7 canonical Wnt signaling pathway GO:0060070 9.82 AXIN1 CTNNB1 SFRP1
8 positive regulation of cell growth GO:0030307 9.81 EGFR SFRP1 SFRP2
9 negative regulation of canonical Wnt signaling pathway GO:0090090 9.81 AXIN1 AXIN2 DACT1 DKK1 FRZB SFRP1
10 cellular response to growth factor stimulus GO:0071363 9.8 CTNNB1 EGFR SFRP1
11 somitogenesis GO:0001756 9.79 AXIN2 SFRP1 SFRP2
12 negative regulation of BMP signaling pathway GO:0030514 9.78 DKK1 SFRP1 SFRP2
13 neural tube development GO:0021915 9.77 DACT1 SFRP1 SFRP2
14 positive regulation of fat cell differentiation GO:0045600 9.76 FRZB SFRP1 SFRP2 WIF1
15 Wnt signaling pathway GO:0016055 9.73 AXIN1 AXIN2 CTNNB1 DACT1 DKK1 FRZB
16 negative regulation of osteoclast differentiation GO:0045671 9.69 CTNNB1 SFRP1
17 beta-catenin destruction complex disassembly GO:1904886 9.69 AXIN1 CTNNB1
18 digestive tract morphogenesis GO:0048546 9.69 EGFR SFRP1 SFRP2
19 negative regulation of ossification GO:0030279 9.68 DKK1 SFRP1
20 negative regulation of JUN kinase activity GO:0043508 9.67 SFRP1 SFRP2
21 endoderm formation GO:0001706 9.67 CTNNB1 DKK1
22 planar cell polarity pathway involved in neural tube closure GO:0090179 9.66 SFRP1 SFRP2
23 negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 9.66 SFRP1 SFRP2
24 negative regulation of catenin import into nucleus GO:0035414 9.65 AXIN2 SFRP5
25 cellular response to X-ray GO:0071481 9.65 SFRP1 SFRP2
26 positive regulation of catenin import into nucleus GO:0035413 9.65 DACT1 EGFR SFRP2
27 regulation of BMP signaling pathway GO:0030510 9.64 SFRP4 SFRP5
28 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.64 AXIN1 SFRP2
29 dorsal/ventral axis specification GO:0009950 9.63 CTNNB1 SFRP1
30 cell morphogenesis involved in differentiation GO:0000904 9.62 CTNNB1 DKK1
31 negative regulation of mesodermal cell fate specification GO:0042662 9.59 DKK1 SFRP2
32 development of primary male sexual characteristics GO:0046546 9.58 SFRP1 SFRP2
33 regulation of establishment of planar polarity GO:0090175 9.58 SFRP1 SFRP2
34 Wnt signaling pathway involved in somitogenesis GO:0090244 9.58 DKK1 SFRP1 SFRP2
35 regulation of centromeric sister chromatid cohesion GO:0070602 9.57 AXIN2 CTNNB1
36 negative regulation of planar cell polarity pathway involved in axis elongation GO:2000041 9.55 SFRP1 SFRP2
37 regulation of midbrain dopaminergic neuron differentiation GO:1904956 9.54 SFRP1 SFRP2
38 regulation of Wnt signaling pathway GO:0030111 9.5 AXIN2 DKK1 SFRP2
39 negative regulation of Wnt signaling pathway GO:0030178 9.32 AXIN1 DACT1 DKK1 FRZB SFRP1 SFRP2
40 negative regulation of transcription from RNA polymerase II promoter GO:0000122 10.09 CTNNB1 DACT1 DKK1 TP53 WWOX
41 apoptotic process GO:0006915 10.07 AXIN1 SFRP2 SFRP5 TP53 WWOX
42 cell differentiation GO:0030154 10.07 CTNNB1 FRZB SFRP1 SFRP2 SFRP4 SFRP5
43 positive regulation of transcription, DNA-templated GO:0045893 10.06 AXIN1 CTNNB1 EGFR SFRP1 TP53
44 multicellular organism development GO:0007275 10.03 AXIN1 AXIN2 DACT1 DKK1 EGFR FRZB

Molecular functions related to Esophageal Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 9.71 AXIN1 AXIN2 EGFR TP53
2 enzyme binding GO:0019899 9.63 AXIN1 AXIN2 CTNNB1 EGFR TP53 WWOX
3 beta-catenin binding GO:0008013 9.54 AXIN1 AXIN2 DACT1
4 protein phosphatase binding GO:0019903 9.5 CTNNB1 EGFR TP53
5 RNA polymerase II transcription factor binding GO:0001085 9.43 CTNNB1 DACT1 TP53
6 I-SMAD binding GO:0070411 9.13 AXIN1 AXIN2 CTNNB1
7 Wnt-protein binding GO:0017147 9.1 FRZB SFRP1 SFRP2 SFRP4 SFRP5 WIF1

Sources for Esophageal Basaloid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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