Esophageal Cancer malady

NIH Rare Diseases: Esophageal cancer is a cancer of the esophagus, the hollow tube that carries food and liquids from the throat to the stomach. As the cancer grows, symptoms may include painful or difficult swallowing, weight loss and coughing up blood. The exact cause is usually not known, but both environmental and genetic factors are throught to play a role in the development of this condition. In the United States, risk factors for developing esophageal cancer include smoking, heavy drinking, obesity, and damage from acid reflux. Treatments include surgery, radiation, chemotherapy, and laser therapy. Some patients may also need nutritional support, since the cancer or treatment may make it hard to swallow.³⁰

MalaCards: Esophageal Cancer, also known as malignant neoplasm of middle third of esophagus, is related to esophagitis and carcinoma. An important gene associated with Esophageal Cancer is DLEC1 (deleted in lung and esophageal cancer 1), and among its related pathways are Cell cycle and Pathways in cancer. The drugs cisplatin and methotrexate and the compounds calcium and estrogen have been mentioned in the context of this disorder. Affiliated tissues include the esophagus, bone marrow and whole blood, and related mouse phenotypes are mortality/aging and growth/size.

Disease Ontology: A gastrointestinal system cancer that is located in the esophagus.⁶

MedlinePlus: The esophagus is a hollow tube that carries food and liquids from your throat to your stomach. early esophageal cancer usually does not cause symptoms. however, as the cancer grows, symptoms may include painful or difficult swallowing, weight loss and coughing up blood. risk factors for developing esophageal cancer include smoking heavy drinking damage from acid reflux treatments include surgery, radiation, chemotherapy and laser therapy. you might also need nutritional support, since the cancer or treatment may make it hard to swallow. nih: national cancer institute²³

Wikipedia: Esophageal cancer (or oesophageal cancer) is malignancy of the esophagus. There are various subtypes,...⁴⁴ more...

OMIM: 133239

Aliases & Descriptions:

esophageal cancer 6 7 30 8 33 23 malignant neoplasm of middle third of esophagus 6 43 esophagus cancer 6 30 malignant tumor of middle third of esophagus (disorder) 6 malignant tumor of upper third of esophagus (disorder) 6 malignant tumor of lower third of esophagus (disorder) 6 malignant tumor of the middle third of the esophagus 6 malignant neoplasm of proximal third of esophagus 6 malignant neoplasm of middle third of oesophagus 6 malignant neoplasm of distal third of esophagus 6 malignant neoplasm of lower third of oesophagus 6 malignant neoplasm of upper third of esophagus 6 malignant neoplasm of lower third of esophagus 6

malignant tumor of proximal third of esophagus 6 malignant tumor of distal third of esophagus 6 malignant neoplasm of upper third esophagus 6 malignant neoplasm of abdominal oesophagus 6 malignant neoplasm of abdominal esophagus 6 malignant tumor of abdominal esophagus 6 ca middle third esophagus (disorder) 6 ca lower third esophagus (disorder) 6 malignant neoplasm of esophagus 43 ca middle third oesophagus 6 ca lower third oesophagus 6 esophageal neoplasms 43 malignant neoplasms 43

Diseases related to esophageal cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1160)

id	Related Disease	Score	Top Affiliating Genes
1	esophagitis	74.2	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD1LG2
2	carcinoma	62.0	ZNF135, PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5
3	prostatitis	44.2	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD4
4	adenocarcinoma	43.7	PIK3CB, PIK3CA, PIK3CG, KLF4, REG1A, CNR1
5	gastric cancer	43.3	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD4
6	leukemia	41.9	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD1LG2
7	pancreatitis	40.8	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD1LG2
8	cervicitis	39.5	PIK3CA, PIK3CG, PDCD1LG2, PDCD4, CNR1, KITLG
9	hepatocellular carcinoma	39.5	PIK3CB, PIK3CA, PIK3CG, PDCD1LG2, PDCD4, REG1A
10	esophageal squamous cell carcinoma	39.2	PIK3CA, PCNA, RB1, SERPINB3, BRCA2, VHL
11	esophageal carcinoma	36.1	PCNA, RB1, VEGFA, VEGFC, MYC, BMP6
12	alcoholism	35.9	CNR1, GSR, GRIN2B, IL1RN, GPT, HTR3A
13	oral squamous cell carcinoma	35.9	PIK3CA, PDCD1LG2, PDCD4, SFRP1, PCNA, RB1
14	squamous cell carcinoma	35.4	SERPINB3, PAK1, CDH1, MMP10, MMP7, MKI67
15	tongue cancer	35.3	PCNA, VHL, VEGFA, MYC, BIRC5, BCL2
16	nasopharynx carcinoma	35.0	VEGFA, RASSF1, CDKN2A, CDH1, MMP9, CCND1
17	liver cancer	34.8	PIK3CG, REG1A, RB1, NAT2, VEGFA, MYC
18	brain cancer	34.5	PIK3CA, PIK3CG, RB1, NAT2, VEGFA, RAD51
19	oral cavity cancer	34.4	NAT2, VEGFA, PARP1, BAX, MPO, GSTM1
20	cervical cancer	33.8	PIK3CA, PIK3CG, SFRP1, PCNA, RB1, RBL1
21	breast cancer	33.6	PIK3CA, BRCA2, MYC, BMP6, PAK1, MTA1
22	salivary gland cancer	33.4	BIRC2, BIRC5, MMP9, AR, MET, FAS
23	hypoxia	33.4	PIK3CB, PIK3CA, PIK3CG, KLF5, PDCD4, KITLG
24	skin cancer	33.2	PIK3CA, CNR1, PCNA, BRCA2, RARS, BIRC5
25	ovarian cancer	33.2	RB1, RBL1, BRCA2, CDKN1A, CDKN2B, CDKN1B
26	pancreatic cancer	32.7	BRCA2, VEGFA, RAN, BIRC5, KDR, MUC1
27	barrett's esophagus	32.6	CDKN2A, CDX2, MKI67, MGMT, FHIT, GSTP1
28	xeroderma pigmentosum	32.5	PCNA, RAD23B, PARP1, BCL2, BAX, MT2A
29	nasopharyngitis	32.5	PIK3CA, PIK3CG, KLF5, KITLG, PCNA, RB1
30	cardia cancer	32.2	PARP1, MTHFR, XRCC1, CDKN2A, GSTM1, GSTP1
31	non-hodgkin lymphoma	31.9	KITLG, RBL1, SELL, NAT2, MYC, BIRC2
32	pancreatic ductal carcinoma	31.9	PIK3CG, SEL1L, VEGFA, MUC1, CDKN2A, MMP9
33	lung carcinoma	31.5	PIK3CA, PIK3CG, KLF4, KITLG, PCNA, RB1
34	thyroid carcinoma	31.5	PIK3CA, PIK3CG, KITLG, PCNA, RB1, SELL
35	liver cirrhosis	31.2	CNR1, SERPINB3, SERPINA3, RASSF1, LEPR, CHKA
36	bronchogenic carcinoma	31.2	CEACAM5, CDKN1A, CDKN2A, GSTM3, IL10, IL1RN
37	urinary bladder cancer	31.1	SFRP1, RB1, NAT2, RASSF1, BIRC5, KDR
38	cervical carcinoma	31.0	PIK3CA, PIK3CG, PDCD1LG2, CNR1, KITLG, PCNA
39	acute lymphoblastic leukemia	30.8	KITLG, RB1, SELL, RAN, BIRC2, BCL2
40	seminoma	30.8	KLF4, REG1A, KITLG, RB1, BRAF, VEGFC
41	kidney cancer	30.8	PIK3CA, BRAF, VHL, VEGFA, RARB, RASSF1
42	stomach carcinoma	30.7	RASSF1, CEACAM5, CDKN2A, CDH1, MLH1, FAS
43	testicular cancer	30.7	NAT2, VEGFC, BMP6, XPC, ATM, CDKN1A
44	colorectal cancer	30.6	NAT2, MYCL1, MTHFR, MTR, XRCC5, MSH2
45	retinoblastoma	30.6	PIK3CB, PIK3CA, PIK3CG, CNTN1, KITLG, PCNA
46	glioblastoma	30.5	PIK3CA, PIK3CG, RB1, VHL, VEGFA, BIRC5
47	thoracic cancer	30.3	KDR, CDKN1A, CASP3, CASP6, CASP8, CASP9
48	malignant pleural mesothelioma	30.3	BIRC5, BCL2L1, MUC1, XIAP, CEACAM5, MET
49	laryngeal carcinoma	30.2	PDCD4, PCNA, RB1, NAT2, VEGFA, VEGFC
50	malignant peripheral nerve sheath tumor	30.2	MUC1, CDKN2B, CDKN2A, CDK4, MET, MDM2

Clinical features from OMIM: 133239

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carboplatin, cisplatin, cisplatin pwdr [va product], methotrexate, methotrexate sodium, profimer sodium

MalaCards organs/tissues related to esophageal cancer:

²²

FMA organs/tissues related to esophageal cancer:

¹¹

MGI Mouse Phenotypes related to esophageal cancer:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	19.8	PIK3CB, PIK3CA, KLF4, KLF5, PDCD1LG2, PDCD4
2	growth/size phenotype	MP:0005378	17.1	PIK3CB, PIK3CA, PIK3CG, KLF5, CNR1, CNTN1
3	hematopoietic system phenotype	MP:0005397	16.9	PDCD1LG2, SFRP1, PCNA, RBL1, BRAF, BRCA2
4	cellular phenotype	MP:0005384	16.3	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD1LG2
5	homeostasis/metabolism phenotype	MP:0005376	15.9	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, PDCD1LG2
6	embryogenesis phenotype	MP:0005380	15.6	PIK3CB, PIK3CA, KLF5, SFRP1, RBBP6, RBL1
7	integument phenotype	MP:0010771	15.1	PIK3CG, KLF4, CNR1, KITLG, RB1, RBL1
8	normal phenotype	MP:0002873	14.9	KLF4, KLF5, RBL1, NAIP, BRAF, BRCA2
9	nervous system phenotype	MP:0003631	14.9	REG1B, CNR1, CNTN1, KITLG, SFRP1, RB1
10	behavior/neurological phenotype	MP:0005386	13.6	PIK3CA, KLF4, REG1B, CNR1, CNTN1, RB1
11	immune system phenotype	MP:0005387	13.1	KLF5, PDCD4, SFRP1, RBL1, SELL, BRAF
12	no phenotypic analysis	MP:0003012	12.9	PDCD1LG2, CNR1, SFRP1, PCNA, RB1, RBL1
13	tumorigenesis	MP:0002006	12.7	PIK3CB, PIK3CA, KLF4, PDCD1LG2, PDCD4, KITLG
14	endocrine/exocrine gland phenotype	MP:0005379	12.5	KLF4, KLF5, PDCD4, REG1A, RBL1, SELL
15	renal/urinary system phenotype	MP:0005367	12.5	PDCD4, BRAF, VHL, RARB, BCL2, KCNQ1OT1
16	reproductive system phenotype	MP:0005389	12.3	PIK3CA, KLF4, PDCD4, REG1A, RBL1, BRCA2
17	digestive/alimentary phenotype	MP:0005381	12.2	KLF4, KLF5, KITLG, RB1, RBL1, BRAF
18	respiratory system phenotype	MP:0005388	11.9	KLF5, SELL, LPL, KCNQ1OT1, LEPR, MT2A
19	craniofacial phenotype	MP:0005382	11.8	KLF4, KITLG, RBL1, RAD23B, LATS2, XPA
20	cardiovascular system phenotype	MP:0005385	11.6	PIK3CB, PIK3CA, PIK3CG, KLF5, KITLG, SFRP1
21	limbs/digits/tail phenotype	MP:0005371	11.3	KITLG, SFRP1, RB1, RBL1, BRCA2, VHL
22	skeleton phenotype	MP:0005390	11.1	PIK3CG, CNR1, KITLG, SFRP1, RB1, RBL1
23	vision/eye phenotype	MP:0005391	11.0	PIK3CA, CNTN1, KITLG, RB1, RBL1, BRAF
24	hearing/vestibular/ear phenotype	MP:0005377	10.7	KITLG, RB1, MYC, RARB, PARP1, BCL2
25	pigmentation phenotype	MP:0001186	10.5	KITLG, RB1, BRAF, MYC, BCL2, LEP
26	liver/biliary system phenotype	MP:0005370	10.5	REG1B, RBL1, SEL1L, VHL, VEGFA, LPL
27	muscle phenotype	MP:0005369	9.6	PIK3CA, PIK3CG, KLF5, CNTN1, RB1, RBL1
28	adipose tissue phenotype	MP:0005375	9.5	PIK3CA, CNR1, SFRP1, RB1, RBL1, BRAF

Articles related to esophageal cancer:

(show top 50)    (show all 541)

id	Title	Authors	Year	Affiliating Genes
1	RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. (22265016)	Blaydon D.C.... Kelsell D.P.	2012	RHBDF2
2	The expression and activation of ERK/MAPK pathway in human esophageal cancer cell line EC9706. (20464500)	Zheng S.T.... Lu X.M.	2011	MAPK3, MAPK1
3	Hypermethylation-modulated downregulation of RASSF1A expression is associated with the progression of esophageal cancer. (21722812)	Mao W.M.... Ling Z.Q.	2011	RASSF1
4	Growth inhibition, morphology change, and cell cycle alterations in NFBD1-depleted human esophageal cancer cells. (20364298)	Yang Z.... Song F.	2010	MDC1
5	Contribution of germ line BRCA2 sequence alterations to risk of familial esophageal cancer in a high-risk area of India. (19473207)	Kaushal M.... Saxena S.	2010	BRCA2
6	The independent effects of cigarette smoking, alcohol consumption, and serum aspartate aminotransferase on the alanine aminotransfer ase ratio in korean men for the risk for esophageal cancer. (20376881)	Kimm H.... Jee S.H.	2010	GPT
7	DNA repair gene xeroderma pigmentosum group D 751 po lymorphism and the risk on esophageal cancer: a meta-analysis (19642387)	Wu X.B.... Zhang J.Y.	2009	ERCC2
8	Expression of esophageal cancer related gene 4 (ECRG4 ), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effec t on the tumor growth in vitro and in vivo. (19521989)	Li L.W.... Lu S.H.	2009	DNMT1, C2orf40
9	Polymorphism Arg290Arg in esophageal-cancer-related gene 1 (ECRG1) is a prognostic factor for survival in esophageal cancer. (19052822)	Bachmann K.... Strate T.	2009	TMPRSS11A
10	Association of human leukocyte antigen and esophageal cancer in North of Iran. (20334121)	Ajami A.... Hedayatizadeh-Omran A.	2009	HLA-A, HLA-C, HLA-B
11	Genetic and epigenetic changes of FHIT gene in patie nts with esophageal cancer (20458975)	Tsao I.... Atramentova L.A.	2009	FHIT
12	Identification of alpha-actinin 4 and 67 kDa laminin receptor as stage-specific markers in esophageal cancer via proteomic approaches. (17960614)	Fu L.... Guan X.Y.	2007	ACTN4, RPSA
13	Short tandem repeat polymorphism in exon 4 of esophageal cancer-related gene 2 detected in genomic DNA is a prognostic marker for esophageal cancer. (17693286)	Kaifi J.T.... Izbicki J.R.	2007	SPINK7
14	Immunological protection against HPV16 E7-expressing human esophageal cancer cell challenge by a novel HPV16-E6/E7 fusion protein based-vaccine in a Hu-PBL-SCID mouse model. (17202676)	Lu Y.... Zhao Q.	2007	GZMB
15	Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. (17912028)	Jain M.... Mittal B.	2007	EGFR, EGF, BCL2
16	Chenodeoxycholic acid stimulates the progression of human esophageal cancer cells: A possible mechanism of angiogenesis in patients with esophageal cancer. (16557574)	Soma T.... Shimada Y.	2006	EGFR, VEGFA, PTGS2
17	Expression and prognostic roles of PABPC1 in esophageal cancer: correlation with tumor progression and postoperative survival. (16465428)	Takashima N.... Fujii Y.	2006	PABPC1
18	MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer. (16702732)	Komoto C.... Okumura K.	2006	ABCB1
19	Effect of acid suppression on molecular predictors for esophageal cancer. (16492917)	Lao-Sirieix P.... Fitzgerald R.C.	2006	MYC, PTGS2
20	Alvocidib (Flavopiridol) suppresses tumor growth in SCID mice with human esophageal cancer xenografts without inducing apoptosis. (17097874)	Sato S.... Tsurumaru M.	2006	RB1, CCND1
21	Inhibitory effects of esophageal cancer related gene 2 on proliferation of human esophageal cancer cell EC9706 (16324322)	Li M.N.... Lu S.H.	2005	SPINK7
22	Inability of transforming growth factor-beta to cause SnoN degradation leads to resistance to transforming growth factor-beta-induced growth arrest in esophageal cancer cells. (15930298)	Edmiston J.S.... Lebman D.A.	2005	BMP6, SKIL
23	Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis. (15773840)	Makino H.... Gabrielson E.	2005	TCEAL1
24	Role for the double-stranded RNA-activated protein ki nase PKR in Ad-TNF-alpha gene therapy in esophageal cancer. (16153435)	von Holzen U.... Swisher S.G.	2005	EIF2AK2
25	Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan. (15790587)	Yang C.X.... Tajima K.	2005	MTR, MTHFR
26	Environmental exposure and p53 mutations in esophageal cancer patients in areas of low and high incidence of esophageal cancer in China. (16272802)	Sakaguchi S.... Nakajima T.	2005	TP53
27	Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2. (16299228)	Okawa T.... Tanaka N.	2005	CEBPB, HPSE
28	Plasma level of transforming growth factor beta1 measured from the azygos vein predicts prognosis in patients with esophageal cancer. (15102678)	Fukuchi M.... Kuwano H.	2004	TGFB1
29	Flavopiridol as a radio-sensitizer for esophageal cancer cell lines. (15569374)	Sato S.... Tsurumaru M.	2004	RB1, BCL2, CCND1
30	A study of correlation between early postoperative relapse with lymph node micrometastasis in patients with N0 esophageal cancer (15009981)	Wang Z.... Chen J.H.	2004	MUC1
31	Short tandem repeat polymorphism in a novel esophageal cancer-related gene (ECRG2) implicates susceptibility to esophageal cancer in Chinese population. (14639608)	Yue C.M.... Lu S.H.	2004	SPINK7
32	SULT1A1 polymorphism and esophageal cancer in males. (12455060)	Wu M.T.... Lee J.M.	2003	SULT1A1
33	Common genetic variants of TP53 and BRCA2 in esophageal cancer patients and healthy individuals from low and high risk areas of northern China. (12670525)	Hu N.... Taylor P.R.	2003	TP53, BRCA2
34	Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray. (12632483)	Wang H.T.... Liu Z.H.	2003	EMP1
35	Aldehyde dehydrogenase-2 genotypes and HLA haplotypes in Japanese patients with esophageal cancer. (12168074)	Watanabe S.... Kuriyama S.	2002	ALDH2, HLA-A, HLA-B
36	Connective tissue growth factor gene expression alters tumor progression in esophageal cancer. (11910473)	Koliopanos A.... BA1chler M.W.	2002	TGFBR2, TGFB1, CTGF
37	Down-regulation of gut-enriched Kruppel-like factor expression in esophageal cancer. (12439907)	Wang N.... Wu M.	2002	KLF4
38	Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer. (11223259)	Wang Q.... Liu Z.	2001	RPL15
39	The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer. (11297249)	Harpole D.H.... Allegra C.	2001	GSTP1, ABCB1
40	Tumor marker expression is predictive of survival in patients with esophageal cancer. (11565671)	Aloia T.A.... D'Amico T.A.	2001	GSTP1, EGFR, TGFA
41	Cisplatin induces fas expression in esophageal cancer cell lines and enhanced cytotoxicity in combination with LAK cells. (11096347)	Matsuzaki I.... Ogawa J.	2000	IL2, FAS
42	Genetic polymorphism in hOGG1 and susceptibility to esophageal cancer in Chinese (11110971)	Xing D.... Lin D.	2000	OGG1
43	Detection of micrometastases in histologically negative lymph nodes in esophageal cancer. (9875777)	Luketich J.D.... Siegfried J.M.	1998	CEACAM5
44	Overexpression of protein tyrosine kinases in human esophageal cancer. (9396043)	Nemoto T.... Hirokawa K.	1997	DDR1
45	Esophageal cancer and aldehyde dehydrogenase-2 genoty pes in Japanese males. (8850269)	Yokoyama A.... Ishii H.	1996	ALDH2
46	Possible predictive markers of immunotherapy in esophageal cancer: retrospective analysis of a randomized study. The Cooperative Study Group for Esophageal Cancer in Japan. (7627722)	Ogoshi K.... Sugita M.	1995	SERPINA3
47	Relation of epidermal growth factor receptor concentr ation to growth of human esophageal cancer cell lines. (8274053)	Shimada Y.... Akiyama T.	1993	EGF
48	Postoperative changes in acute phase protein in patients with esophageal cancer (1380633)	Shirao K.... Shimazu H.	1992	HP
49	Esophageal cancer and diet--a case-control study. (1408949)	Prasad M.P.... Quereshi M.A.	1992	ALB
50	Expression of c-myc and HER-1 genes in the development of human esophageal cancer (1786750)	Liang Y.Y.	1991	MYC

Genes related to esophageal cancer according to GeneCards:

(show top 50)    (show all 484)

id	Symbol	Description	Score	GeneCards Section Context
1	DLEC1	deleted in lung and esophageal cancer 1	11.1	Orthologs, Transcripts, Publications, Aliases & Descriptions (show all 5 sections) Proteins
2	C2orf40	chromosome 2 open reading frame 40	11.0	Publications, Aliases & Descriptions
3	LOC100421153	deleted in lung and esophageal cancer 1 pseudogene	11.0	Aliases & Descriptions
4	GAEC1	gene amplified in esophageal cancer 1	11.0	Aliases & Descriptions
5	LZTS1	leucine zipper, putative tumor suppressor 1	11.0	Aliases & Descriptions
6	TMPRSS11A	transmembrane protease, serine 11A	11.0	Publications, Aliases & Descriptions
7	RPS15	ribosomal protein S15	11.0	Summaries
8	DEC1	deleted in esophageal cancer 1	11.0	Aliases & Descriptions, Publications
9	ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	11.0	Publications
10	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	11.0	Publications
11	TOC	tylosis with oesophageal cancer	11.0
12	KLF4	Kruppel-like factor 4 (gut)	11.0	Publications
13	IFI27	interferon, alpha-inducible protein 27	10.9	Publications
14	GSTM1	glutathione S-transferase mu 1	10.9	Publications
15	CDK4	cyclin-dependent kinase 4	10.9	Publications
16	CCND1	cyclin D1	10.9	Publications
17	RARB	retinoic acid receptor, beta	10.9	Publications
18	BAX	BCL2-associated X protein	10.9	Publications
19	TOP1	topoisomerase (DNA) I	10.9
20	MIR608	microRNA 608	10.9	Publications
21	MIR631	microRNA 631	10.9	Publications
22	SPINK7	serine peptidase inhibitor, Kazal type 7 (putative)	10.9	Publications
23	MIR492	microRNA 492	10.9	Publications
24	MIR16-2	microRNA 16-2	10.9	Publications
25	MIR604	microRNA 604	10.9	Publications
26	MIR373	microRNA 373	10.9	Publications
27	MIR375	microRNA 375	10.9	Publications
28	MIR219-1	microRNA 219-1	10.9	Publications
29	MIR30C1	microRNA 30c-1	10.9	Publications
30	MIR423	microRNA 423	10.9	Publications
31	MIR30A	microRNA 30a	10.9	Publications
32	MIR100	microRNA 100	10.9	Publications
33	MIR30E	microRNA 30e	10.9	Publications
34	MIR26A1	microRNA 26a-1	10.9	Publications
35	MIR124-1	microRNA 124-1	10.9	Publications
36	MIR10B	microRNA 10b	10.9	Publications
37	MT1M	metallothionein 1M	10.9	Publications
38	CSAG3	CSAG family, member 3	10.9	Publications
39	MIR200C	microRNA 200c	10.9	Publications
40	MIR196A2	microRNA 196a-2	10.9	Publications
41	NPIP	nuclear pore complex interacting protein	10.9
42	CSAG2	CSAG family, member 2	10.9	Publications
43	SERTAD1	SERTA domain containing 1	10.9	Publications
44	REG1B	regenerating islet-derived 1 beta	10.9	Publications
45	KCNQ1OT1	KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)	10.9	Publications
46	CRNN	cornulin	10.9	Publications
47	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	10.9	Publications
48	ZNRD1	zinc ribbon domain containing 1	10.9	Publications
49	MYCL1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	10.9	Publications
50	CLDN6	claudin 6	10.9	Publications

Pathways related to esophageal cancer according to GeneDecks:

(show top 50)    (show all 248)

id	Pathway	Score	Top Affiliating Genes
1	Cell cycle20	12.2	PCNA, RB1, RBL1, MYC, ZBTB17, ATM
2	Pathways in cancer20	11.9	PIK3CB, PIK3CA, PIK3CG, RB1, BRCA2, VEGFA
3	DNA Repair Mechanisms36	11.7	PCNA, BRCA2, RAD51, RAD23B, XRCC1, XRCC5
4	Glioma Invasiveness36	11.5	KITLG, VEGFC, BMP6, ITGAE, ITGB2, FIGF
5	Breast Cancer Regulation by Stathmin136	11.4	PAK1, FIGF, FGF2, FGF4, FGF7, FGFR2
6	Paxillin Interactions36	11.3	KITLG, VEGFC, PAK1, KDR, ITGAE, ITGB2
7	Actin-Based Motility by Rho Family GTPases36	11.0	PAK1, ITGAE, FGF4, FGF7, IL2, IGF1
8	Angiogenesis3	10.9	VHL, VEGFC, KDR, MMP2, MMP7, MMP9
9	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.9	BCL2, CASP9, ERBB3, CYCS, NTRK1, NGF
10	Apoptosis Signaling Pathways37	10.9	NAIP, BIRC2, BIRC3, BIRC5, BCL2, BCL2L1
11	p53 Signaling36	10.8	BCL2, BAX, ATM, CDKN1A, CDK4, FOS
12	Colorectal cancer20	10.8	PIK3CB, PIK3CG, BRAF, MSH2, FOS, CASP9
13	Pancreatic Adenocarcinoma36	10.8	KITLG, RB1, BRAF, BRCA2, VEGFC, BMP6
14	Ras Pathway36	10.8	BRAF, VEGFC, KDR, JUN, ITGAE, FOS
15	Akt Signaling36	10.6	PIK3CG, VEGFC, ITGAE, ITGB2, FIGF, FGF4
16	Glioblastoma Multiforme36	10.6	RB1, BRAF, CDKN1A, CDKN1B, CDK4, MGMT
17	IP3 Pathway36	10.5	KITLG, VEGFC, BMP6, KDR, FLT1, FIGF
18	ErbB signaling pathway20	10.5	PIK3CB, PIK3CA, PIK3CG, BRAF, MYC, PAK1
19	PTEN Pathway36	10.5	KITLG, BRAF, VEGFC, KDR, ITGAE, ITGB2
20	Hepatitis C20	10.5	PIK3CB, PIK3CA, PIK3CG, BRAF, CLDN5, CLDN3
21	Measles20	10.4	PIK3CB, PIK3CA, PIK3CG, CDKN1B, CDK4, IRF3
22	Apoptosis20	10.4	PIK3CB, PIK3CA, PIK3CG, BIRC2, BIRC3, BCL2
23	Signal transduction AKT signaling10	10.4	PIK3CB, PDPK1
24	Rho Family GTPases36	10.3	KITLG, VEGFC, BMP6, PAK1, KDR, BCL2
25	14-3-3 Induced Intracellular Signaling36	10.2	KITLG, VEGFC, JUN, FLT1, FIGF, FGF2
26	p53 Mediated Apoptosis36	10.1	KITLG, VEGFC, BMP6, KDR, BCL2, BAX
27	mTOR signaling pathway20	10.1	PIK3CB, PIK3CA, PIK3CG, BRAF, VEGFA, VEGFC
28	GSK3 Signaling36	10.1	KITLG, VEGFC, BMP6, KDR, CDH13, CDH1
29	Non-small cell lung cancer20	10.0	PIK3CB, PIK3CA, PIK3CG, RB1, BRAF, RASSF1
30	Activation of PKC through GPCR36	9.9	KITLG, VEGFC, BMP6, KDR, FLT1, FIGF
31	PPAR Pathway36	9.9	KITLG, VEGFC, ITGAE, ITGB2, FLT1, FIGF
32	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.9	PIK3CB, PIK3CA, BCL2, BAX, JUN, CDK1
33	Activation of cAMP-Dependent PKA36	9.9	KITLG, VEGFC, KDR, FLT1, FIGF, FGF4
34	MAPK signaling pathway20	9.9	BRAF, MYC, PAK1, JUN, CD14, CDC25B
35	Rac1 Pathway36	9.8	KITLG, BMP6, PAK1, KDR, JUN, ITGAE
36	Transcription Receptor-mediated HIF regulation10	9.8	MAPK3, MAPK1, IGF1R, IGFBP3, IGF1, AKT2
37	Activation of PKA through GPCR36	9.7	KITLG, BRAF, VEGFC, BMP6, KDR, FLT1
38	p70S6K Signaling36	9.7	KITLG, VEGFC, BMP6, KDR, FLT1, FIGF
39	Apoptotic Pathways in Synovial Fibroblasts36	9.7	KITLG, VEGFC, BMP6, KDR, FLT1, FIGF
40	Cellular Apoptosis Pathway36	9.6	KITLG, VEGFC, VDAC1, BMP6, BIRC2, KDR
41	Apoptosis and survival_Caspase cascade41	9.6	PARP1, BAX, XIAP, FASLG, FAS, IGF1R
42	Development IGF-RI signaling10	9.6	PIK3CB, PIK3CA, MYC, BCL2L1, MTOR, MAPK3
43	Development_IGF-1 receptor signaling41	9.6	PIK3CB, PIK3CA, MYC, BCL2L1, MTOR, MAPK3
44	Toxoplasmosis20	9.6	PIK3CB, PIK3CA, PIK3CG, BIRC2, BIRC3, BCL2
45	Cytokine-cytokine receptor interaction20	9.5	KITLG, VEGFA, VEGFC, KDR, LEP, LEPR
46	GPCR Pathway36	9.5	KITLG, BRAF, VEGFC, BMP6, PAK1, KDR
47	MAPK Signaling36	9.4	KITLG, BRAF, VEGFC, MYC, BMP6, PAK1
48	Apoptosis and survival Caspase cascade10	9.3	PARP1, BAX, XIAP, FASLG, FAS, IGF1R
49	Influenza A20	9.3	PIK3CB, PIK3CA, PIK3CG, VDAC1, JUN, IRF3
50	TGF-beta Signaling Pathways37	9.2	PIK3CB, PIK3CG, BRAF, MYC, MTOR, JUN

Compounds related to esophageal cancer according to GeneDecks:

(show top 50)    (show all 485)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	17.5	REG1A, REG1B, CNR1, KITLG, RB1, RBL1
2	estrogen32	14.3	PIK3CB, KLF5, PCNA, SERPINA3, NAT2, BRCA2
3	lipid32	14.2	PIK3CB, PIK3CA, PIK3CG, CNR1, KITLG, PCK2
4	nitric oxide32 9 18 9	16.1	PIK3CB, KLF4, KITLG, RB1, NAT2, VHL
5	ethanol32 34 9 18 9	17.0	KITLG, RARB, LEPR, CHKA, MUC1, MTR
6	glucose32	13.0	BRAF, VHL, VEGFC, PAK1, MT2A, XIAP
7	retinoic acid32 42 18	14.4	PIK3CA, PIK3CG, KITLG, PCK2, RB1, SELL
8	bromodeoxyuridine32	11.7	PIK3CA, KITLG, PCNA, RB1, MYC, BMP6
9	cyclic amp32 18	12.6	CNR1, PCK2, RB1, BRAF, RARS, RARB
10	adpribose32	11.6	PIK3CA, PIK3CG, PCNA, RB1, BRCA2, BIRC5
11	bleomycin32 9 9	13.5	BRCA2, XRCC1, XRCC5, XRCC6, ATM, CDKN3
12	manganese superoxide32	11.3	BCL2L1, XRCC1, ATM, CD14, GSR, GSTM1
13	malondialdehyde32	11.3	CHKA, MPO, GSR, GSTM1, GSTT1, GPT
14	ribonucleic acid32	11.2	KITLG, VEGFC, MYC, BMP6, RARB, LEPR
15	formaldehyde32 18	12.2	PCNA, RB1, SELL, MUC1, MPO, CDKN1B
16	dmso32	11.2	KITLG, BMP6, S100A9, CD36, MMP7, F3
17	egcg32	11.1	PIK3CG, BCL2L1, XIAP, MAPK3, IGFBP3, CASP9
18	glycerol32 9 18 9	14.1	PCK2, PCNA, LPL, VDAC1, LEP, CD36
19	carbohydrates32	11.1	SELL, CEACAM5, CD14, CDH1, MKI67, MGAT5
20	irinotecan32 34 9 9	14.1	BRAF, VEGFA, PARP1, BCL2L1, UMPS, BAX
21	paclitaxel32 34 9 9	14.0	PIK3CA, PIK3CG, KITLG, PCNA, RB1, BRAF
22	glutamine32	11.0	PIK3CG, PCK2, PCNA, BRCA2, LPL, VDAC1
23	mannitol32 9 9	12.9	CDKN3, CDH1, FGF2, ANGPT1, MAPK3, IFNA2
24	dutp32	10.8	PCNA, BIRC5, PARP1, BCL2, BCL2L1, BAX
25	n acetylcysteine32	10.8	PCNA, BIRC5, KDR, CEBPB, ATM, CDKN1A
26	trastuzumab32 34 9 9	13.8	PIK3CA, PIK3CG, VEGFC, BIRC5, KDR, MUC1
27	gf 109203x32 42	11.8	PIK3CB, PIK3CG, KITLG, VEGFA, JUN, CDKN1A
28	tamoxifen32 34 9 9	13.8	PIK3CA, PCNA, BRCA2, VEGFA, LPL, MYC
29	sulforaphane32	10.7	PIK3CG, RB1, PARP1, JUN, CDKN1A, MGMT
30	acetylcholine32 9 18 9	13.7	CNR1, SERPINA3, LPL, BMP6, PAK1, LEP
31	daunorubicin32 9 9	12.5	KITLG, MYC, BIRC5, BCL2, BCL2L1, BAX
32	polysaccharide32	10.5	KITLG, SELL, SERPINA3, LPL, VDAC1, BMP6
33	sulindac sulfide32	10.5	PCNA, BMP6, BCL2, BCL2L1, BAX, JUN
34	progestin32	10.5	VEGFA, KDR, CDK4, CDH1, AR, CCND1
35	butyrate32	10.4	KLF4, KITLG, PCNA, RB1, MYC, BMP6
36	okadaic acid32 42	11.4	PIK3CA, RB1, MYC, BMP6, BCL2, BCL2L1
37	phosphotyrosine32	10.3	PIK3CB, PIK3CA, PIK3CG, KDR, CDKN3, CDK1
38	resveratrol32 9 18 9	13.3	PIK3CA, PIK3CG, PCNA, RB1, BRCA2, VEGFA
39	mg 13232 42	11.3	PIK3CG, PCK2, PCNA, MYC, BIRC3, BIRC5
40	anisomycin32 42 9 9	13.1	PIK3CG, MYC, MTOR, JUN, FOS, IL1B
41	4-hydroxynonenal32 18	11.1	MYC, PARP1, CHKA, BAX, MPO, JUN
42	silymarin32	10.0	PCNA, VEGFA, BMP6, BIRC5, PARP1, JUN
43	sodium bisulfite32	10.0	RARB, RASSF1, CDKN2B, CDKN2A, CDH1, MLH1
44	dihydrotestosterone32 9 18 9	13.0	LPL, BMP6, LEP, CHKA, CDK4, AR
45	genistein32 9 18 9	12.8	PIK3CA, PIK3CG, REG1A, KITLG, PCK2, PCNA
46	mitoxantrone32 9 9	11.8	BIRC5, BCL2, MTOR, ATM, MPO, FASLG
47	vitamin d32	9.7	LPL, BMP6, RARS, RARB, LEPR, CHKA
48	imatinib32 34 9 9	12.1	PIK3CA, PIK3CG, KITLG, SELL, BRAF, VEGFA
49	pdtc32	9.0	PIK3CA, PIK3CG, BIRC3, BIRC5, PARP1, BCL2
50	herbimycin a32 42	9.4	PIK3CG, KITLG, SELL, MYC, BMP6, JUN

Cellular components related to esophageal cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	18.0	RPS6KB1, DAP3, DDX20, SUPT7L, SUFU, TBX21
2	cytoplasm	GO:005737	16.9	HIF1A, SKIL, PDPK1, PDGFRA, RNF6, PIWIL1
3	cytosol	GO:005829	14.9	GEMIN4, GAPDH, EPRS, EPAS1, ADH6, DPYD
4	nucleoplasm	GO:005654	13.9	ATM, MYC, VHL, BRCA2, RBL1, RB1
5	extracellular region	GO:005576	11.5	CXCL2, CXCL12, CXCL1, CXADR, PSG2, DCN
6	cell surface	GO:009986	10.4	THBD, HBEGF, ELANE, ABCB1, SHH, RPS6KB1
7	plasma membrane	GO:005886	10.2	SPHK1, CTGF, CTNNA1, CTNNB1, NTRK1, PPL
8	platelet alpha granule lumen	GO:031093	10.0	TGFB2, TGFB1, TIMP1, ACTN4, EGF, PF4
9	extracellular space	GO:005615	8.6	FASLG, MMP9, MMP7, MMP2, MMP10, CDH13

Biological processes related to esophageal cancer according to GeneDecks:

(show top 50)    (show all 73)

id	Name	GO ID	Score	Top Affiliating Genes
1	gene expression	GO:010467	13.1	RBL1, MYC, RARS, RARB, RAN, PARP1
2	DNA repair	GO:006281	12.6	PCNA, BRCA2, RAD51, RAD23B, PARP1, XRCC1
3	cell proliferation	GO:008283	12.5	REG1B, KITLG, PCNA, BCL2L1, UCHL1, MT3
4	xenobiotic metabolic process	GO:006805	12.4	NAT2, MTR, GSTM1, GSTP1, ALDH2, PTGS2
5	G1/S transition of mitotic cell cycle	GO:000082	12.2	PCNA, RB1, BCL2, LATS2, CDKN1A, CDKN1B
6	signal transduction	GO:007165	11.8	PIK3CB, KITLG, VEGFC, RARB, RAN, CHKA
7	response to organic cyclic compound	GO:014070	11.6	SFRP1, MSH2, ATP12A, JUN, CDKN1A, CDK1
8	positive regulation of cell proliferation	GO:008284	11.5	KLF5, REG1A, SFRP1, SERTAD1, VEGFA, VEGFC
9	negative regulation of transcription from RNA polymerase II promoter	GO:000122	11.4	KLF4, VHL, MYC, RARB, PARP1, LEP
10	apoptotic process	GO:006915	11.3	PDCD4, VDAC1, BIRC2, BIRC3, BIRC5, PAK1
11	positive regulation of cell division	GO:051781	11.3	VEGFA, VEGFC, FIGF, FGF2, FGF3, FGF4
12	positive regulation of apoptotic process	GO:043065	11.3	CNR1, SFRP1, RARB, BAX, ATM, MMP9
13	virus-host interaction	GO:019048	11.3	RB1, RBL1, VDAC1, RAN, KDR, BAX
14	response to drug	GO:042493	11.3	SFRP1, VEGFC, LPL, MYC, BCL2, BAG1
15	cellular response to hypoxia	GO:071456	11.2	SFRP1, VHL, VEGFA, MT3, MTOR, MDM2
16	negative regulation of transcription, DNA-dependent	GO:045892	11.2	KLF4, PDCD4, SFRP1, RB1, BIRC5, MT3
17	angiogenesis	GO:001525	11.2	PIK3CA, PIK3CG, KLF5, VEGFA, VEGFC, KDR
18	negative regulation of cell proliferation	GO:008285	11.2	KLF4, SFRP1, VHL, RARB, JUN, CDKN1A
19	cell cycle arrest	GO:007050	11.1	RB1, MYC, RASSF1, MSH2, ATM, CDKN1A
20	response to lipopolysaccharide	GO:032496	11.0	CNR1, S100A9, CEBPB, JUN, MMP9, IL23R
21	response to ethanol	GO:045471	11.0	CNR1, BCL2, S100A9, CDK1, MMP9, MGMT
22	positive regulation of gene expression	GO:010628	11.0	CNTN1, BRAF, VEGFA, MT3, CDK1, MET
23	transforming growth factor beta receptor signaling pathway	GO:007179	11.0	RBL1, MYC, PARP1, JUN, CDKN2B, FOS
24	response to estrogen stimulus	GO:043627	11.0	BCL2, GSTM3, FAS, ANGPT1, CCND1, ESR1
25	cytokine-mediated signaling pathway	GO:019221	11.0	MT2A, ISG20, IRF1, IRF2, IRF3, IL1B
26	positive regulation of transcription, DNA-dependent	GO:045893	10.9	KLF4, KLF5, SFRP1, RB1, SERTAD1, BRCA2
27	induction of apoptosis	GO:006917	10.9	BAX, CEBPB, CDKN1B, CDKN2A, IRF1, IRF3
28	negative regulation of neuron apoptotic process	GO:043524	10.9	NAIP, BRAF, BCL2, BCL2L1, BAX, MT3
29	wound healing	GO:042060	10.9	PAK1, FGF2, FGF7, IL1B, ENG, ERBB3
30	response to estradiol stimulus	GO:032355	10.8	BRCA2, AURKA, MMP15, MMP9, IL1B, ANXA1
31	induction of apoptosis by intracellular signals	GO:008629	10.6	MYC, BCL2, BCL2L1, BAX, XIAP, CDKN1A
32	response to hypoxia	GO:001666	10.6	VEGFA, CLDN3, PAK1, BCL2, LEP, MT3
33	negative regulation of apoptotic process	GO:043066	10.6	PIK3CG, SFRP1, BRAF, VEGFA, MYC, BIRC2
34	response to heat	GO:009408	10.5	BCL2, CD14, MMP9, IRF1, IL1B, HSPA4
35	heart development	GO:007507	10.3	PCNA, ATM, ID1, CASP3, CASP8, ERBB3
36	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.3	KLF4, RB1, RBL1, VEGFA, MYC, BMP6
37	insulin receptor signaling pathway	GO:008286	10.3	PIK3CB, PIK3CA, MTOR, CDK1, FGF2, FGF3
38	blood coagulation	GO:007596	10.2	PIK3CB, PIK3CA, PIK3CG, SELL, VEGFA, VEGFC
39	positive regulation of DNA replication	GO:045740	10.2	KITLG, JUN, CDK1, MET, IGF1R, IGF1
40	positive regulation of cell migration	GO:030335	10.2	VEGFA, KDR, CDH13, FLT1, APC, IGF1R
41	Ras protein signal transduction	GO:007265	10.1	RB1, BRAP, RASSF1, CDKN1A, CDKN2A, CDK1
42	fibroblast growth factor receptor signaling pathway	GO:008543	10.0	PIK3CA, BRAF, MTOR, CDKN1B, CDK1, FGF2
43	positive regulation of protein phosphorylation	GO:001934	10.0	VEGFA, MT3, MTOR, IL1B, ENG, MAPK3
44	inflammatory response	GO:006954	10.0	PIK3CG, SERPINA3, BMP6, S100A9, CEBPB, CD14
45	anti-apoptosis	GO:006916	10.0	PIK3CA, NAIP, BRAF, VHL, BIRC2, BIRC3
46	platelet degranulation	GO:002576	9.9	VEGFA, VEGFC, CD36, FLNA, FIGF, IGF1
47	phosphatidylinositol-mediated signaling	GO:048015	9.8	PIK3CB, PIK3CA, PCNA, MTOR, AURKA, CDKN1B
48	epidermal growth factor receptor signaling pathway	GO:007173	9.3	PIK3CA, MTOR, CDKN1B, CDK1, MDM2, MAPK3
49	platelet activation	GO:030168	9.2	PIK3CB, PIK3CA, PIK3CG, VEGFA, VEGFC, CD36
50	positive regulation of smooth muscle cell proliferation	GO:048661	9.1	JUN, CDH13, FLT1, IL6, IL6R, IGF1

Molecular functions related to esophageal cancer according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	18.8	TOP1, WWOX, LZTS1, SKIL, PDPK1, PDIA3
2	ATP binding	GO:005524	11.6	PTK2, DICER1, DDR1, DDX20, DAPK1, SPHK1
3	protein homodimerization activity	GO:042803	11.5	CRP, SMAD4, SMAD3, NTRK1, SP1, PTS
4	transcription factor binding	GO:008134	11.4	SUFU, SP1, CTNNB1, SMAD3, HIF1A, DNAJA3
5	heparin binding	GO:008201	11.3	CTGF, RSPO1, RSPO4, PF4, ELANE, HBEGF
6	protein kinase binding	GO:019901	11.1	TP53, TP73, PTEN, PTK2, PTPN1, SUFU
7	transcription regulatory region DNA binding	GO:044212	10.9	WT1, NFKB1, SMAD4, SMAD3, PPARG, HIF1A
8	identical protein binding	GO:042802	10.8	PTS, TNF, TP73, TP53, ERBB2, ESR1
9	double-stranded DNA binding	GO:003690	10.7	CTNNB1, SMAD3, NFKB1, WT1, EGFR, EGR1
10	growth factor activity	GO:008083	10.5	HDGF, IL10, FGF7, FGF4, FGF3, FGF2
11	enzyme binding	GO:019899	10.1	PPARG, CTNNB1, CYP2E1, CYP2A6, CYP1A2, PLAUR