MCID: ESP021
MIFTS: 81

Esophageal Cancer malady

Cancer diseases, Gastrointestinal diseases, Skin diseases categories

Summaries for Esophageal Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Esophageal cancer is a cancer of the esophagus, the hollow tube that carries food and liquids from the throat to the stomach. as the cancer grows, symptoms may include painful or difficult swallowing, weight loss and coughing up blood. the exact cause is usually not known, but both environmental and genetic factors are throught to play a role in the development of this condition. in the united states, risk factors for developing esophageal cancer include smoking, heavy drinking, obesity, and damage from acid reflux. treatments include surgery, radiation, chemotherapy, and laser therapy. some patients may also need nutritional support, since the cancer or treatment may make it hard to swallow. last updated: 1/12/2012

MalaCards: Esophageal Cancer, also known as esophageal carcinoma, is related to nasopharynx carcinoma and lung cancer, and has symptoms including endobrachyesophagus/barrett esophagus, esophageal neoplasm/tumor/carcinoma/cancer and weight loss/loss of appetite/break in weight curve/general health alteration. An important gene associated with Esophageal Cancer is TGFBR2 (transforming growth factor, beta receptor II (70/80kDa)), and among its related pathways are Pathways in cancer and Integrated Breast Cancer Pathway. The drugs cisplatin and methotrexate and the compounds thymidylate and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include the esophagus, lymph node and lung.

Disease Ontology:8 A gastrointestinal system cancer that is located in the esophagus.

MedlinePlus:33 The esophagus is a hollow tube that carries food and liquids from your throat to your stomach. early esophageal cancer usually does not cause symptoms. later, you may have symptoms such as painful or difficult swallowing weight loss a hoarse voice or cough that doesn't go away you're at greater risk for getting esophageal cancer if you smoke, drink heavily, or have acid reflux. your risk also goes up as you age your doctor uses imaging tests and a biopsy to diagnose esophageal cancer. treatments include surgery, radiation, and chemotherapy. you might also need nutritional support, since the cancer or treatment may make it hard to swallow. nih: national cancer institute

Wikipedia:63 Esophageal cancer (or oesophageal cancer) is malignancy of the esophagus. There are various subtypes,... more...

Description from OMIM:46 133239

Aliases & Classifications for Esophageal Cancer

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 48Orphanet, 33MedlinePlus, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

48
esophageal cancer:
Prevalence: 1-9/100000; Age of onset: Adulthood
esophageal squamous cell carcinoma:
Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

esophageal cancer 8 9 42 46 10 48 33
esophageal carcinoma 8 44 48 60
malignant neoplasm of middle third of esophagus 8 60
esophagus cancer 8 42
malignant tumor of the middle third of the esophagus 8
malignant neoplasm of proximal third of esophagus 8
malignant neoplasm of middle third of oesophagus 8
malignant neoplasm of distal third of esophagus 8
malignant neoplasm of lower third of oesophagus 8
malignant neoplasm of lower third of esophagus 8
malignant neoplasm of upper third of esophagus 8
malignant tumor of proximal third of esophagus 8
malignant tumor of middle third of esophagus 8
malignant tumor of distal third of esophagus 8
malignant tumor of lower third of esophagus 8
malignant tumor of upper third of esophagus 8
malignant neoplasm of upper third esophagus 8
malignant neoplasm of abdominal oesophagus 8
malignant neoplasm of abdominal esophagus 8
malignant tumor of abdominal esophagus 8
squamous cell carcinoma of esophagus 60
esophageal squamous cell carcinoma 48
esophageal epidermoid carcinoma 48
malignant neoplasm of esophagus 60
ca middle third oesophagus 8
ca middle third esophagus 8
ca lower third oesophagus 8
ca lower third esophagus 8
carcinoma of oesophagus 8
carcinoma of esophagus 8
esophageal neoplasms 60
cancer of oesophagus 8
malignant neoplasms 60
cancer of esophagus 8


External Ids:

Disease Ontology8 DOID:5041, DOID:1107
MeSH34 D004938
NCIt39 C3028, C3513
OMIM46 133239
ICD10 via Orphanet26 C15
SNOMED-CT via Orphanet57 372138000, 276804009
UMLS via Orphanet61 C0152018
ICD1025 C15, C15.4, C15.5

Related Diseases for Esophageal Cancer

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Esophageal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 756)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharynx carcinoma30.9BAX, CDK4, GSTM1, TGFBR2
2lung cancer30.8CCND1, IFI27, TOP1, BAX, CDK4, GSTM1
3squamous cell carcinoma30.7KLF4, CCND1, IFI27, TOP1, BAX, CDK4
4adenocarcinoma30.6KLF4, CCND1, IFI27, TOP1, BAX, CDK4
5non-small cell lung carcinoma30.5CCND1, IFI27, TOP1, BAX, CDK4, GSTM1
6lung small cell carcinoma30.5TOP1, BAX, GSTM1, TGFBR2
7cervical cancer30.4IFI27, BAX, GSTM1
8gallbladder cancer30.4TGFBR2
9colon cancer30.4CCND1, TOP1, BAX, CDK4, TGFBR2
10breast cancer30.3KLF4, CCND1, IFI27, TOP1, BAX, CDK4
11colorectal cancer30.3CCND1, IFI27, TOP1, BAX, CDK4, TGFBR2
12retinoblastoma30.3TGFBR2, CDK4, BAX, IFI27, CCND1
13laryngeal squamous cell carcinoma30.3CCND1, IFI27, BAX, GSTM1, TGFBR2
14leiomyoma30.3TGFBR2
15endometrial carcinoma30.1CCND1, IFI27, BAX, CDK4, TGFBR2
16myeloid leukemia30.1TOP1, BAX, CDK4
17rectal neoplasm30.1BAX, IFI27
18hepatoblastoma30.1TOP1
19pancreatic cancer30.1KLF4, CCND1, IFI27, TOP1, BAX, CDK4
20ovarian cancer30.0CCND1, IFI27, TOP1, BAX, CDK4, TGFBR2
21multiple myeloma30.0CCND1
22bladder carcinoma30.0BAX
23leiomyosarcoma30.0CDK4
24burkitt's lymphoma30.0CDK4, BAX, IFI27
25melanoma29.9CCND1, IFI27, TOP1, BAX, CDK4
26transitional cell carcinoma29.8IFI27, GSTM1, TGFBR2
27prostate cancer29.8BAX, TOP1, IFI27, CCND1, CDK4, DLC1
28leukemia29.8KLF4, CCND1, IFI27, TOP1, BAX, CDK4
29hepatocellular carcinoma29.8CCND1, IFI27, BAX, CDK4, DLC1, GSTM1
30lung adenocarcinoma29.8CCND1, TOP1, BAX, GSTM1, TGFBR2
31stomach cancer29.8CCND1, IFI27, BAX, TGFBR2
32esophageal squamous cell carcinoma29.8LZTS1, DEC1
33acute leukemia29.8GSTM1, TOP1
34thyroid cancer29.8GSTM1, CCND1
35gastric adenocarcinoma29.8GSTM1, BAX, KLF4
36sarcoma29.8GSTM1, CDK4, TOP1
37colon adenocarcinoma29.8BAX, TOP1
38medulloblastoma29.8CDK4, TOP1
39ductal carcinoma in situ29.8CCND1
40esophagitis11.4
41gastric squamous cell carcinoma11.0
42lymph node cancer10.7
43tongue cancer10.6
44thoracic cancer10.6
45gastric cardia adenocarcinoma10.6
46lip cancer10.6
47squamous cell papilloma10.5
48barrett's esophagus10.5
49lung squamous cell carcinoma10.5
50vascular cancer10.5

Graphical network of the top 20 diseases related to Esophageal Cancer:



Diseases related to esophageal cancer

Clinical Features for Esophageal Cancer

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

133239

Symptoms:

48 (show all 14)
  • endobrachyesophagus/barrett esophagus
  • esophageal neoplasm/tumor/carcinoma/cancer
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • abnormal cry/voice/phonation disorder/nasal speech
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • chronic hiccup
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • thoracic/chest pain
  • lymphadenopathy/polyadenopathies
  • anomalies of the neck
  • intestinal/colonic anomaly
  • cough
  • generalized obesity

Drugs & Therapeutics for Esophageal Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Esophageal Cancer

Drug clinical trials:

Search ClinicalTrials for Esophageal Cancer

Search NIH Clinical Center for Esophageal Cancer

Search CenterWatch for Esophageal Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Esophageal Cancer

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Anatomical Context for Esophageal Cancer

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Esophageal Cancer:

32
Lymph node, Lung, Testes, Endothelial, Colon, Testis, T cells, Breast, Liver, Brain, Bone, Bone marrow, Thyroid, Prostate, Whole blood, Heart, Skeletal muscle, Pituitary

FMA organs/tissues related to Esophageal Cancer:

14
The esophagus

Animal Models for Esophageal Cancer or affiliated genes

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Publications for Esophageal Cancer

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Sources:
50PubMed
See all sources

Articles related to Esophageal Cancer:

(show top 50)    (show all 1400)
idTitleAuthorsYear
1
Clinical and oncological effects of triplet chemotherapy followed by radical esophagectomy for resectable esophageal cancer associated with unfavorable prognostic factors. (23963503)
2013
2
Overexpression of metastasis-associated in colon cancer-1 associated with poor prognosis in patients with esophageal cancer. (23737034)
2013
3
Statin use and the risk of esophageal cancer: a population-based case-control study. (23470154)
2013
4
Extended lymphadenectomy in esophageal cancer is crucial. (23625012)
2013
5
Definitive Radiotherapy for Cervical Esophageal Cancer. (24347470)
2013
6
MMP-2 and DcR3 expression in esophageal cancer tissue and correlation with patient survival. (24040480)
2013
7
Dosimetric and clinical predictors of acute esophagitis in lung cancer patients in Turkey treated with radiotherapy. (23991980)
2013
8
MicroRNA expression differentiates squamous epithelium from Barrett's esophagus and esophageal cancer. (23925817)
2013
9
Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin. (23582790)
2013
10
Clinicopathological and prognostic significance of chemokine receptor CXCR4 overexpression in patients with esophageal cancer: a meta-analysis. (24326770)
2013
11
Reduction in cardiac volume during chemoradiotherapy for patients with esophageal cancer. (24094627)
2013
12
Meta-analysis shows clinically relevant and long-lasting deterioration in health-related quality of life after esophageal cancer surgery. (24293086)
2013
13
Comparison of patient-specific internal gross tumor volume for radiation treatment of primary esophageal cancer based separately on three-dimensional and four-dimensional computed tomography images. (23796234)
2013
14
Induction chemotherapy or chemoradiotherapy followed by radical esophagectomy for T4 esophageal cancer: results of a prospective cohort study. (23649529)
2013
15
Esophageal cancer with esophageal duplication cyst. (23816110)
2013
16
Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice. (23291985)
2013
17
Fruit and vegetable consumption and risk of esophageal cancer: a case-control study in north-west China. (24148025)
2013
18
CRT combined with a sequential VMAT boost in the treatment of upper thoracic esophageal cancer. (24036867)
2013
19
Combining proteomics, serum biomarkers and bioinformatics to discriminate between esophageal squamous cell carcinoma and pre-cancerous lesion. (23225851)
2012
20
Thoracoscopic esophagectomy and hand-assisted laparoscopic gastric mobilization for esophageal cancer with situs inversus totalis. (22125175)
2012
21
Nanog siRNA plus Cisplatin may enhance the sensitivity of chemotherapy in esophageal cancer. (22714588)
2012
22
RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. (22265016)
2012
23
Small interfering RNA in silencing cox-2 expression enhances radiosensitivity of esophageal cancer EC9706 cell]. (22944132)
2012
24
Chyluria after ligation of the thoracic duct: a rare complication after thoracoscopic-assisted esophagectomy for esophageal cancer. (23229840)
2012
25
PLC-I/1 gene polymorphisms significantly enhance the risk of esophageal squamous cell carcinoma in individuals with a family history of upper gastrointestinal cancers. (23079034)
2012
26
Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer. (22676270)
2012
27
Mechanism of loss of human esophageal cancer-related gene 4 (ECRG4) gene expression in esophageal squamous cell carcinoma cell line EC9706]. (22325214)
2011
28
Potential role of minichromosome maintenance protein 2 as a screening biomarker in esophageal cancer high-risk population in China. (21237484)
2011
29
Polymorphism in epidermal growth factor receptor intron 1 predicts prognosis of patients with esophageal cancer after chemoradiation and surgery. (21298351)
2011
30
p53 Mutation status predicts pathological response to chemoradiotherapy in locally advanced esophageal cancer. (19885698)
2010
31
KrA1ppel-like factor 4 represses transcription of the survivin gene in esophageal cancer cell lines. (19361279)
2009
32
Achalasia combined with esophageal cancer treated by concurrent chemoradiation therapy. (20431771)
2009
33
Expression of matrix metalloproteinase-9 in the neoplastic and interstitial inflammatory infiltrate cells in the different histopathological types of esophageal cancer. (19141401)
2008
34
The pan-erbB tyrosine kinase inhibitor CI-1033 inhibits human esophageal cancer cells in vitro and in vivo. (17342332)
2007
35
Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium. (16865228)
2006
36
Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach. (16103445)
2005
37
Inability of transforming growth factor-beta to cause SnoN degradation leads to resistance to transforming growth factor-beta-induced growth arrest in esophageal cancer cells. (15930298)
2005
38
Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. (15151617)
2004
39
Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma. (12527901)
2003
40
Cyclooxygenase-2 expression in esophageal cancer cells and induction by mitomycin C]. (14633464)
2003
41
Tricorporal priapism in a patient with metastatic esophageal cancer. (12809922)
2003
42
Changes in the localization of heat shock protein 72 correlated with development of thermotolerance in human esophageal cancer cell line. (14981913)
2003
43
Connective tissue growth factor gene expression alters tumor progression in esophageal cancer. (11910473)
2002
44
A complete response after neoadjuvant chemotherapy for advanced gastric cancer with esophageal invasion]. (11816467)
2002
45
Arsenic trioxide induced human esophageal cancer Ec109 cell apoptosis with downregulation of c-myc gene expression]. (12903497)
2000
46
Antiemetic effect of ramosetron during hyperthermo-chemo-radiotherapy for esophageal cancer. (11268430)
2000
47
Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics. (10591585)
1999
48
Correlation studies on the alterations of multiple tumor suppressor genes in human esophageal cancer and in human and monkey esophageal epithelial cells treated with N-methyl-N-benzyl nitrosamine]. (7587888)
1995
49
Action of granulocyte-colony stimulating factor and cisplatin on two models of human digestive, esophageal and colonic, cancers]. (7537191)
1993-1994
50
Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers. (1913694)
1991

Genetic Variations for Esophageal Cancer

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Esophageal Cancer:

62
id Symbol AA change Variation ID SNP ID
1TGFBR2p.Glu526GlnVAR_015816

Expression for genes affiliated with Esophageal Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Esophageal Cancer

Search GEO for disease gene expression data for Esophageal Cancer.

Pathways for genes affiliated with Esophageal Cancer

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Sources:
29KEGG, 37NCBI BioSystems Database, 55SinoBiological, 51QIAGEN
See all sources

Pathways related to Esophageal Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0TGFBR2, CDK4, BAX, CCND1
211.0TGFBR2, CDK4, BAX, CCND1
311.0TGFBR2, CDK4, BAX, CCND1
411.0CCND1, TOP1, BAX, CDK4
5
Hide members
10.9TGFBR2, CDK4, CCND1
6
Hide members
10.9CCND1, BAX, CDK4
7
Hide members
10.9CCND1, BAX, CDK4
8
Hide members
10.9CDK4, BAX, CCND1

Compounds for genes affiliated with Esophageal Cancer

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
See all sources

Compounds related to Esophageal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1thymidylate4411.7CCND1, IFI27, TOP1, BAX, CDK4, GSTM1
2doxorubicin44 49 1113.7GSTM1, CDK4, BAX, TOP1, IFI27, CCND1
3cisplatin44 49 59 1114.7CCND1, IFI27, TOP1, BAX, CDK4, GSTM1
4eb 108944 5912.6TGFBR2, CDK4, BAX, IFI27, CCND1
5adpribose4411.6CCND1, IFI27, TOP1, BAX, CDK4
6paclitaxel44 49 1113.5CCND1, IFI27, TOP1, BAX, CDK4
7pd 98,0594411.5KLF4, CCND1, IFI27, BAX, CDK4
8ly2940024411.5TGFBR2, CDK4, BAX, IFI27, CCND1
9n-(4-hydroxyphenyl)retinamide4411.5CCND1, BAX, CDK4, TGFBR2
10indole-3-carbinol4411.5CDK4, BAX, IFI27, CCND1
11cycloheximide4411.5CCND1, TOP1, BAX, CDK4, TGFBR2
12flavopiridol44 1112.4CCND1, TOP1, BAX, CDK4
13gefitinib44 49 1113.4CCND1, IFI27, TOP1, CDK4
14vincristine44 49 1113.4CCND1, TOP1, BAX, GSTM1
15troglitazone44 28 59 1114.4CCND1, IFI27, BAX, CDK4
16quercetin44 59 11 2414.4CCND1, IFI27, BAX, CDK4
175fluorouracil4411.4GSTM1, CDK4, BAX, TOP1
18retinoid4411.4CCND1, IFI27, BAX, CDK4
19ursolic acid4411.3CCND1, TOP1, BAX
20norcantharidin4411.3BAX, IFI27, CCND1
21gossypol4411.3CDK4, BAX, CCND1
22n acetylcysteine4411.3CDK4, BAX, IFI27, CCND1
23apigenin44 2812.3CCND1, BAX, CDK4
24olomoucine44 1112.3CDK4, BAX, CCND1
25lycopene44 2412.3CDK4, IFI27, CCND1
26sulindac44 1112.3BAX, IFI27, CCND1
27sulforaphane4411.2CCND1, BAX, GSTM1
28roscovitine4411.2CCND1, IFI27, CDK4
29trastuzumab44 49 1113.2CCND1, IFI27, CDK4
30tamoxifen44 49 28 1114.2CCND1, IFI27, BAX, TGFBR2
31bortezomib44 1112.2BAX, TOP1, CCND1
32carboplatin44 49 1113.2TOP1, CDK4, GSTM1
33inostamycin4411.2CCND1, BAX
34dl 111it4411.2CCND1, CDK4
35optimax4411.1IFI27, CCND1
36vitamin d4411.1TGFBR2, GSTM1, CDK4, IFI27
37bleomycin44 1112.1TOP1, GSTM1, TGFBR2
38pga24411.1CCND1, CDK4
39pyrene4411.1CDK4, GSTM1
40ag-1264411.0CCND1, CDK4
414,6-diamidino-2-phenylindole4411.0TOP1, BAX
42berberine4411.0CCND1, CDK4
43depsipeptide4411.0CCND1
4410-hydroxycamptothecin4411.0TOP1, BAX
45gemcitabine44 49 1112.9CCND1, TOP1, BAX
46beta-lapachone4410.9BAX, TOP1
47lovastatin44 49 59 28 1114.8CCND1, IFI27, CDK4
48ginsenoside4410.7BAX, CCND1
49vitamin k24410.7CDK4, BAX
50sp 60012544 5911.6CDK4, BAX, CCND1

GO Terms for genes affiliated with Esophageal Cancer

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Sources:
16Gene Ontology
See all sources

Cellular components related to Esophageal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00030710.7CDK4, CCND1

Biological processes related to Esophageal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249311.0TGFBR2, CDK4, TOP1, CCND1
2organ regenerationGO:03110010.8TGFBR2, CDK4, CCND1
3activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.6IFI27, BAX, DLC1

Products for genes affiliated with Esophageal Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophageal Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet