MCID: ESP021
MIFTS: 68

Esophageal Cancer malady

Cancer, Gastrointestinal categories

Summaries for Esophageal Cancer

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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NIH Rare Diseases:43 Esophageal cancer is a cancer of the esophagus, the hollow tube that carries food and liquids from the throat to the stomach. as the cancer grows, symptoms may include painful or difficult swallowing, weight loss and coughing up blood. the exact cause is usually not known, but both environmental and genetic factors are throught to play a role in the development of this condition. in the united states, risk factors for developing esophageal cancer include smoking, heavy drinking, obesity, and damage from acid reflux. treatments include surgery, radiation, chemotherapy, and laser therapy. some patients may also need nutritional support, since the cancer or treatment may make it hard to swallow. last updated: 1/12/2012

MalaCards: Esophageal Cancer, also known as esophageal carcinoma, is related to esophageal squamous cell carcinoma and nasopharynx carcinoma, and has symptoms including generalized obesity, nausea/vomiting/regurgitation/merycism/hyperemesis and feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia. An important gene associated with Esophageal Cancer is DLEC1 (deleted in lung and esophageal cancer 1), and among its related pathways are Pathways in cancer and Integrated Breast Cancer Pathway. The drugs cisplatin and methotrexate and the compounds thymidylate and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include the esophagus.

Disease Ontology:8 A gastrointestinal system cancer that is located in the esophagus.

MedlinePlus:34 The esophagus is a hollow tube that carries food and liquids from your throat to your stomach. early esophageal cancer usually does not cause symptoms. later, you may have symptoms such as painful or difficult swallowing weight loss a hoarse voice or cough that doesn't go away you're at greater risk for getting esophageal cancer if you smoke, drink heavily, or have acid reflux. your risk also goes up as you age your doctor uses imaging tests and a biopsy to diagnose esophageal cancer. treatments include surgery, radiation, and chemotherapy. you might also need nutritional support, since the cancer or treatment may make it hard to swallow. nih: national cancer institute

Wikipedia:64 Esophageal cancer (or oesophageal cancer) is malignancy of the esophagus. There are various subtypes,... more...

Description from OMIM:47 133239

Aliases & Classifications for Esophageal Cancer

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
esophageal cancer:
Prevalence: 1-9/100000; Age of onset: Adulthood
esophageal squamous cell carcinoma:
Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

esophageal cancer 8 9 43 47 10 49 34
esophageal carcinoma 8 45 49 61
malignant neoplasm of middle third of esophagus 8 61
esophagus cancer 8 43
malignant tumor of the middle third of the esophagus 8
malignant neoplasm of proximal third of esophagus 8
malignant neoplasm of middle third of oesophagus 8
malignant neoplasm of distal third of esophagus 8
malignant neoplasm of lower third of oesophagus 8
malignant neoplasm of lower third of esophagus 8
malignant neoplasm of upper third of esophagus 8
malignant tumor of proximal third of esophagus 8
malignant tumor of middle third of esophagus 8
malignant tumor of distal third of esophagus 8
malignant tumor of lower third of esophagus 8
malignant tumor of upper third of esophagus 8
malignant neoplasm of upper third esophagus 8
malignant neoplasm of abdominal oesophagus 8
malignant neoplasm of abdominal esophagus 8
malignant tumor of abdominal esophagus 8
squamous cell carcinoma of esophagus 61
esophageal squamous cell carcinoma 49
malignant neoplasm of esophagus 61
esophageal epidermoid carcinoma 49
ca middle third oesophagus 8
ca middle third esophagus 8
ca lower third oesophagus 8
ca lower third esophagus 8
carcinoma of oesophagus 8
carcinoma of esophagus 8
esophageal neoplasms 61
cancer of oesophagus 8
malignant neoplasms 61
cancer of esophagus 8


External Ids:

Disease Ontology8 DOID:5041, DOID:1107
MeSH35 D004938
NCIt40 C3028, C3513
OMIM47 133239
ICD10 via Orphanet26 C15
SNOMED-CT via Orphanet58 372138000
UMLS via Orphanet62 C0152018
ICD1025 C15, C15.4, C15.5

Related Diseases for Esophageal Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Esophageal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 389)
idRelated DiseaseScoreTop Affiliating Genes
1esophageal squamous cell carcinoma30.8LZTS1, DEC1
2nasopharynx carcinoma30.8BAX, CDK4, GSTM1, TGFBR2
3squamous cell carcinoma30.8KLF4, CCND1, IFI27, TOP1, BAX, CDK4
4adenocarcinoma30.7KLF4, CCND1, IFI27, TOP1, BAX, CDK4
5oral cancer30.6GSTM1, CDK4, BAX, IFI27, CCND1
6acute lymphoblastic leukemia, childhood30.4GSTM1, CDK4, BAX
7colorectal cancer30.3CCND1, IFI27, TOP1, BAX, CDK4, TGFBR2
8adenoma30.3KLF4, CCND1, IFI27, BAX, CDK4, GSTM1
9leukoplakia30.2GSTM1, IFI27
10oral leukoplakia30.2IFI27, GSTM1
11stomach cancer29.9CCND1, IFI27, BAX, TGFBR2
12acute leukemia29.9GSTM1, TOP1
13thyroid cancer29.9GSTM1, CCND1
14transitional cell carcinoma29.8IFI27, GSTM1, TGFBR2
15ductal carcinoma in situ29.8CCND1
16gastric squamous cell carcinoma11.0
17gastric cardia adenocarcinoma10.9
18squamous cell papilloma10.8
19thoracic cancer10.7
20tongue cancer10.6
21vascular cancer10.5
22tylosis with esophageal cancer10.5
23esophagus small cell carcinoma10.5
24small cell carcinoma10.5
25esophageal cancer, somatic10.4
26cardia cancer10.4
27dysphagia10.4
28atrophic gastritis10.4
29barrett's esophagus10.4
30epiglottis cancer10.3
31tracheoesophageal fistula10.3
32barrett esophagus/esophageal adenocarcinoma10.3
33intrahepatic gall duct cancer10.3
34achalasia10.2
35tracheal cancer10.2
36iritis10.2
37parathyroid carcinoma10.2
38acute t cell leukemia10.2
39eosinophilic esophagitis10.2
40gastric small cell carcinoma10.2
41pemphigus10.2
42alcoholic gastritis10.2
43gastroesophageal junction adenocarcinoma10.2
44large cell carcinoma10.2
45esophageal lipoma10.2
46t cell deficiency10.2
47t-cell leukemia10.2
48apo a-i deficiency10.2
49syncope10.2
50lung cancer susceptibility 510.2

Graphical network of the top 20 diseases related to Esophageal Cancer:



Diseases related to esophageal cancer

Clinical Features for Esophageal Cancer

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

133239

Symptoms:

49 (show all 14)
  • generalized obesity
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • chronic hiccup
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • abnormal cry/voice/phonation disorder/nasal speech
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • thoracic/chest pain
  • cough
  • intestinal/colonic anomaly
  • anomalies of the neck
  • lymphadenopathy/polyadenopathies
  • esophageal neoplasm/tumor/carcinoma/cancer
  • endobrachyesophagus/barrett esophagus

Drugs & Therapeutics for Esophageal Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Esophageal Cancer

Drug clinical trials:

Search ClinicalTrials for Esophageal Cancer

Search NIH Clinical Center for Esophageal Cancer

Search CenterWatch for Esophageal Cancer

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Esophageal Cancer

Anatomical Context for Esophageal Cancer

Sources:
14FMA
See all sources

FMA organs/tissues related to Esophageal Cancer:

14
The esophagus

Animal Models for Esophageal Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Esophageal Cancer

Sources:
51PubMed
See all sources

Articles related to Esophageal Cancer:

(show top 50)    (show all 1385)
idTitleAuthorsYear
1
Technical Improvement of Total Pharyngo-Laryngo-Esophagectomy for Esophageal Cancer and Head and Neck Cancer. (24390709)
2014
2
Modeling Pathologic Response of Esophageal Cancer to Chemoradiation Therapy Using Spatial-Temporal (18)F-FDG PET Features, Clinical Parameters, and Demographics. (24189128)
2014
3
Reply to Letter: "End-to-End Versus End-to-Side Esophagogastrostomy After Esophageal Cancer Resection: A Prospective Randomized Study". (23442777)
2014
4
Esophageal cancer awareness in Bomet district, Kenya. (23658578)
2013
5
Trihalomethanes in drinking water and the risk of death from esophageal cancer: does hardness in drinking water matter? (23294300)
2013
6
DNA polymerase beta promoter mutations affect gene transcription, translation and the sensitivity of esophageal cancer cells to cisplatin treatment. (23117284)
2013
7
Surgical resection for esophageal cancer synchronously or metachronously associated with head and neck cancer. (23358793)
2013
8
Prognostic Significance of Positive Circumferential Resection Margin in Esophageal Cancer: A Systematic Review and Meta-Analysis. (24365211)
2013
9
Radiation therapy and esophageal cancer. (23571700)
2013
10
Minimally invasive surgery for esophageal cancer. (23158082)
2013
11
Salivary microRNAs as promising biomarkers for detection of esophageal cancer. (23560033)
2013
12
Evolution in surgical management of esophageal cancer. (23797119)
2013
13
XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms in esophageal cancer risk: a meta-analysis. (23543084)
2013
14
A CD90(+) tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer. (23382045)
2013
15
Green tea consumption and risk of esophageal cancer: a meta-analysis of published epidemiological studies. (23909723)
2013
16
Dietary habits and esophageal cancer. (23795778)
2013
17
The role of endoscopy in the assessment and treatment of esophageal cancer. (23410694)
2013
18
Epidemiology of esophageal cancer. (24039351)
2013
19
Nonsynonymous polymorphisms in FAT4 gene are associated with the risk of esophageal cancer in an Eastern Chinese population. (23319386)
2013
20
Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype. (22767218)
2012
21
Nanog siRNA plus Cisplatin may enhance the sensitivity of chemotherapy in esophageal cancer. (22714588)
2012
22
RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. (22265016)
2012
23
Barrett's esophagus and esophageal cancer: an overview. (22615011)
2012
24
Combination of biodegradable stent placement and single-dose brachytherapy is associated with an unacceptably high complication rate in the treatment of dysphagia from esophageal cancer. (22695208)
2012
25
Role of survivin gene promoter polymorphism (-31G>C) in susceptibility and survival of esophageal cancer in northern India. (20957442)
2011
26
RAD001 offers a therapeutic intervention through inhibition of mTOR as a potential strategy for esophageal cancer. (20204306)
2010
27
Modulation of lymphocyte regulation for cancer therapy: a phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma. (20179239)
2010
28
shRNA interference for extracellular signal-regulated kinase 2 can inhibit the growth of esophageal cancer cell line Eca109. (20415541)
2010
29
High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy. (20657182)
2010
30
Effect of fractioned irradiation on HIF-1alpha and MDR1 expression in esophageal cancer cells]. (20501388)
2010
31
The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (19472401)
2009
32
Survivin expression in esophageal cancer: correlation with p53 mutations and promoter polymorphism. (19018856)
2009
33
Elevation of circulating interleukin-8 is related to lymph node and distant metastases in esophageal squamous cell carcinomas--implication for clinical evaluation of cancer patient. (18182303)
2008
34
Multipoint quantification of multimarker genes in peripheral blood and micrometastasis characteristic in peri-operative esophageal cancer patients. (18082938)
2008
35
TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. (19020730)
2008
36
Identification and functional characterization of JWA polymorphisms and their association with risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population. (17479402)
2007
37
Involvement of oxidative stress in experimentally induced reflux esophagitis and esophageal cancer. (17591057)
2007
38
Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer. (17171785)
2006
39
Negative implication of C-MYC as an amplification target in esophageal cancer. (16490593)
2006
40
Inhibitory effects of esophageal cancer related gene 2 on proliferation of human esophageal cancer cell EC9706]. (16324322)
2005
41
Induction of apoptosis of lung and esophageal cancer cells treated with the combination of histone deacetylase inhibitor (trichostatin A) and protein kinase C inhibitor (calphostin C). (15632825)
2005
42
A study of correlation between early postoperative relapse with lymph node micrometastasis in patients with N0 esophageal cancer]. (15009981)
2004
43
Connective tissue growth factor gene expression alters tumor progression in esophageal cancer. (11910473)
2002
44
Mutational spectrum induced by acetaldehyde in the HPRT gene of human T lymphocytes resembles that in the p53 gene of esophageal cancers. (11698345)
2001
45
Detection of human papillomavirus DNA and p53 gene mutations in esophageal cancer samples and adjacent normal mucosa. (11549832)
2001
46
p53, p21(Waf1/Cip1) and cyclin D1 protein expression and prognosis in esophageal cancer. (10466043)
1999
47
In vitro and in vivo studies on the biologic effects and molecular mechanism of recombinant RA538 and antisense C-myc adenovirus on human gastric, esophageal and cancer cell lines with high-expression of Bcl-2 gene]. (12532785)
1999
48
Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics. (10591585)
1999
49
Immunohistochemical study of p53, p27 and PCNA expression in esophageal cancer]. (9703805)
1998
50
Prognostic factors for esophageal cancer--from the viewpoint of molecular biology]. (8687232)
1996

Genetic Variations for Esophageal Cancer

Expression for genes affiliated with Esophageal Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Esophageal Cancer

Search GEO for disease gene expression data for Esophageal Cancer.

Pathways for genes affiliated with Esophageal Cancer

Sources:
30KEGG, 38NCBI BioSystems Database, 56SinoBiological, 52QIAGEN
See all sources

Pathways related to Esophageal Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0TGFBR2, CDK4, BAX, CCND1
211.0TGFBR2, CDK4, BAX, CCND1
311.0TGFBR2, CDK4, BAX, CCND1
411.0CCND1, TOP1, BAX, CDK4
5
Hide members
10.9TGFBR2, CDK4, CCND1
6
Hide members
10.9CCND1, BAX, CDK4
7
Hide members
10.9CCND1, BAX, CDK4
8
Hide members
10.9CDK4, BAX, CCND1

Compounds for genes affiliated with Esophageal Cancer

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
See all sources

Compounds related to Esophageal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1thymidylate4511.7TOP1, IFI27, CCND1, BAX, CDK4, GSTM1
2doxorubicin45 50 1113.7GSTM1, TOP1, IFI27, CCND1, BAX, CDK4
3cisplatin45 50 60 1114.7CDK4, GSTM1, IFI27, CCND1, BAX, TOP1
4eb 108945 6012.6CCND1, TGFBR2, CDK4, BAX, IFI27
5adpribose4511.6CDK4, CCND1, IFI27, TOP1, BAX
6paclitaxel45 50 1113.5CCND1, IFI27, BAX, TOP1, CDK4
7pd 98,0594511.5CDK4, CCND1, KLF4, BAX, IFI27
8ly2940024511.5CDK4, BAX, IFI27, CCND1, TGFBR2
9indole-3-carbinol4511.5CCND1, CDK4, BAX, IFI27
10n-(4-hydroxyphenyl)retinamide4511.5CCND1, BAX, TGFBR2, CDK4
11cycloheximide4511.5CCND1, TGFBR2, CDK4, BAX, TOP1
12flavopiridol45 1112.4BAX, CDK4, CCND1, TOP1
13gefitinib45 50 1113.4CCND1, IFI27, CDK4, TOP1
14vincristine45 50 1113.4BAX, CCND1, GSTM1, TOP1
15troglitazone45 29 60 1114.4CDK4, BAX, IFI27, CCND1
16quercetin45 60 11 2414.4CCND1, CDK4, BAX, IFI27
175fluorouracil4511.4GSTM1, TOP1, CDK4, BAX
18retinoid4511.4BAX, IFI27, CCND1, CDK4
19ursolic acid4511.3CCND1, BAX, TOP1
20norcantharidin4511.3IFI27, CCND1, BAX
21gossypol4511.3CCND1, BAX, CDK4
22n acetylcysteine4511.3IFI27, CDK4, CCND1, BAX
23apigenin45 2912.3BAX, CDK4, CCND1
24olomoucine45 1112.3BAX, CCND1, CDK4
25lycopene45 2412.3CCND1, CDK4, IFI27
26sulindac45 1112.3IFI27, CCND1, BAX
27sulforaphane4511.2CCND1, GSTM1, BAX
28roscovitine4511.2CDK4, IFI27, CCND1
29trastuzumab45 50 1113.2CCND1, IFI27, CDK4
30bortezomib45 1112.2CCND1, BAX, TOP1
31tamoxifen45 50 29 1114.2IFI27, TGFBR2, BAX, CCND1
32carboplatin45 50 1113.2GSTM1, TOP1, CDK4
33inostamycin4511.2BAX, CCND1
34dl 111it4511.2CDK4, CCND1
35optimax4511.1CCND1, IFI27
36vitamin d4511.1IFI27, GSTM1, CDK4, TGFBR2
37bleomycin45 1112.1TOP1, GSTM1, TGFBR2
38pga24511.1CDK4, CCND1
39pyrene4511.1GSTM1, CDK4
404,6-diamidino-2-phenylindole4511.0BAX, TOP1
41ag-1264511.0CDK4, CCND1
42berberine4511.0CDK4, CCND1
43depsipeptide4511.0CCND1
4410-hydroxycamptothecin4510.9BAX, TOP1
45gemcitabine45 50 1112.9CCND1, BAX, TOP1
46beta-lapachone4510.9BAX, TOP1
47lovastatin45 50 60 29 1114.8CDK4, IFI27, CCND1
48ginsenoside4510.7CCND1, BAX
49exisulind4510.7BAX, CCND1
50sp 60012545 6011.6CDK4, BAX, CCND1

GO Terms for genes affiliated with Esophageal Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Esophageal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00030710.7CDK4, CCND1

Biological processes related to Esophageal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249311.0TGFBR2, CDK4, TOP1, CCND1
2organ regenerationGO:03110010.8CCND1, CDK4, TGFBR2
3activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.6DLC1, IFI27, BAX

Products for genes affiliated with Esophageal Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophageal Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet