Esophageal Cancer malady
Categories: Genetic diseases, Rare diseases, Cancer diseases, Gastrointestinal diseases, Skin diseases
50OMIM, 33LifeMap Discovery®, 11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 68UniProtKB/Swiss-Prot, 12diseasecard, 36MedlinePlus, 52Orphanet, 25GTR, 48Novoseek, 66UMLS, 37MeSH, 43NCIt, 28ICD10, 30ICD9CM, 29ICD10 via Orphanet, 35MedGen, 60SNOMED-CT, 62The Human Phenotype Ontology
See all MalaCards sources
Aliases & Descriptions for Esophageal Cancer:
Orphanet epidemiological data:52
esophageal squamous cell carcinoma:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/100000 (Worldwide); Age of onset: Adult; Age of death: adult
Inheritance: autosomal dominant inheritance
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Gastrointestinal diseases, Skin diseases
ICD10: 29 28
Rare gastroenterological diseases
OMIM:50 Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is one of the most common cancers worldwide.... (133239) more...
MalaCards based summary: Esophageal Cancer, also known as esophageal carcinoma, is related to gastric cancer and lung cancer, and has symptoms including weight loss, feeding difficulties in infancy and esophageal neoplasm. An important gene associated with Esophageal Cancer is TGFBR2 (Transforming Growth Factor Beta Receptor 2), and among its related pathways are Colorectal Cancer Metastasis and Endometrial cancer. The drugs cisplatin and methotrexate have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and testes, and related mouse phenotypes are liver/biliary system and pigmentation.
Disease Ontology:11 A esophageal cancer that has material basis in abnormally proliferating cells derives from epithelial cells.
NIH Rare Diseases:46 Esophageal cancer is a cancer of the esophagus, the hollow tube that carries food and liquids from the throat to the stomach. as the cancer grows, symptoms may include painful or difficult swallowing, weight loss and coughing up blood. the exact cause is usually not known, but both environmental and genetic factors are throught to play a role in the development of this condition. in the united states, risk factors for developing esophageal cancer include smoking, heavy drinking, obesity, and damage from acid reflux. treatments include surgery, radiation, chemotherapy, and laser therapy. some patients may also need nutritional support, since the cancer or treatment may make it hard to swallow. last updated: 1/12/2012
UniProtKB/Swiss-Prot:68 Esophageal cancer: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
MedlinePlus:36 The esophagus is a hollow tube that carries food and liquids from your throat to your stomach. early esophageal cancer usually does not cause symptoms. later, you may have symptoms such as painful or difficult swallowing weight loss a hoarse voice or cough that doesn't go away you're at greater risk for getting esophageal cancer if you smoke, drink heavily, or have acid reflux. your risk also goes up as you age your doctor uses imaging tests and a biopsy to diagnose esophageal cancer. treatments include surgery, radiation, and chemotherapy. you might also need nutritional support, since the cancer or treatment may make it hard to swallow. nih: national cancer institute
Wikipedia:69 Esophageal cancer (or oesophageal cancer) is cancer arising from the esophagus—the food pipe that runs... more...
Symptoms by clinical synopsis from OMIM:133239
Clinical features from OMIM:133239
Symptoms:52 (show all 8)
HPO human phenotypes related to Esophageal Cancer:(show all 14)
UMLS symptoms related to Esophageal Cancer:abdominal pain, constipation, coughing, diarrhea, dyspepsia, heartburn, nausea and vomiting, snoring, sore throat, vertigo/dizziness, equilibration disorder, gastrointestinal gas
FDA approved drugs:
Drugs for Esophageal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 266)
Interventional clinical trials:(show top 50) (show all 1317)
Search NIH Clinical Center for Esophageal Cancer
Inferred drug relations via UMLS66/NDF-RT44:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Esophageal Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Esophageal Cancer:
Embryonic/Adult Cultured Cells Related to Esophageal Cancer:
Genetic tests related to Esophageal Cancer:
MalaCards organs/tissues related to Esophageal Cancer:34
Lung, Lymph node, Testes, Liver, Breast, Prostate, T cells
MGI Mouse Phenotypes related to Esophageal Cancer:39
Articles related to Esophageal Cancer:(show top 50) (show all 1460)
UniProtKB/Swiss-Prot genetic disease variations for Esophageal Cancer:68
Clinvar genetic disease variations for Esophageal Cancer:5
Cosmic variations for Esophageal Cancer:8 (show top 50) (show all 3996)
Copy number variations for Esophageal Cancer from CNVD:6 (show top 50) (show all 64)
Search GEO for disease gene expression data for Esophageal Cancer.
Pathways related to Esophageal Cancer according to GeneCards Suite gene sharing:(show all 23)
Cellular components related to Esophageal Cancer according to GeneCards Suite gene sharing:
Biological processes related to Esophageal Cancer according to GeneCards Suite gene sharing:(show all 8)
Molecular functions related to Esophageal Cancer according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet