MCID: ESP021
MIFTS: 81

Esophageal Cancer malady

Cancer diseases, Gastrointestinal diseases, Skin diseases categories

Summaries for Esophageal Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Esophageal cancer is a cancer of the esophagus, the hollow tube that carries food and liquids from the throat to the stomach. as the cancer grows, symptoms may include painful or difficult swallowing, weight loss and coughing up blood. the exact cause is usually not known, but both environmental and genetic factors are throught to play a role in the development of this condition. in the united states, risk factors for developing esophageal cancer include smoking, heavy drinking, obesity, and damage from acid reflux. treatments include surgery, radiation, chemotherapy, and laser therapy. some patients may also need nutritional support, since the cancer or treatment may make it hard to swallow. last updated: 1/12/2012

MalaCards: Esophageal Cancer, also known as esophageal carcinoma, is related to nasopharynx carcinoma and lung cancer, and has symptoms including lymphadenopathy/polyadenopathies, abnormal cry/voice/phonation disorder/nasal speech and abnormal cry/voice/phonation disorder/nasal speech. An important gene associated with Esophageal Cancer is TGFBR2 (transforming growth factor, beta receptor II (70/80kDa)), and among its related pathways are Pathways in cancer and Integrated Breast Cancer Pathway. The drugs cisplatin and methotrexate and the compounds thymidylate and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include the esophagus, lymph node and lung.

Disease Ontology:8 A gastrointestinal system cancer that is located in the esophagus.

MedlinePlus:33 The esophagus is a hollow tube that carries food and liquids from your throat to your stomach. early esophageal cancer usually does not cause symptoms. later, you may have symptoms such as painful or difficult swallowing weight loss a hoarse voice or cough that doesn't go away you're at greater risk for getting esophageal cancer if you smoke, drink heavily, or have acid reflux. your risk also goes up as you age your doctor uses imaging tests and a biopsy to diagnose esophageal cancer. treatments include surgery, radiation, and chemotherapy. you might also need nutritional support, since the cancer or treatment may make it hard to swallow. nih: national cancer institute

Wikipedia:63 Esophageal cancer (or oesophageal cancer) is malignancy of the esophagus. There are various subtypes,... more...

Description from OMIM:46 133239

Aliases & Classifications for Esophageal Cancer

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases, Skin diseases


Characteristics (Orphanet epidemiological data):

48
esophageal cancer:
Prevalence: 1-9/100000; Age of onset: Adulthood
esophageal squamous cell carcinoma:
Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

esophageal cancer 8 9 42 46 10 48 33
esophageal carcinoma 8 44 48 60
malignant neoplasm of middle third of esophagus 8 60
esophagus cancer 8 42
malignant tumor of the middle third of the esophagus 8
malignant neoplasm of proximal third of esophagus 8
malignant neoplasm of middle third of oesophagus 8
malignant neoplasm of distal third of esophagus 8
malignant neoplasm of lower third of oesophagus 8
malignant neoplasm of lower third of esophagus 8
malignant neoplasm of upper third of esophagus 8
malignant tumor of proximal third of esophagus 8
malignant tumor of middle third of esophagus 8
malignant tumor of distal third of esophagus 8
malignant tumor of lower third of esophagus 8
malignant tumor of upper third of esophagus 8
malignant neoplasm of upper third esophagus 8
malignant neoplasm of abdominal oesophagus 8
malignant neoplasm of abdominal esophagus 8
malignant tumor of abdominal esophagus 8
squamous cell carcinoma of esophagus 60
esophageal squamous cell carcinoma 48
malignant neoplasm of esophagus 60
esophageal epidermoid carcinoma 48
ca middle third oesophagus 8
ca middle third esophagus 8
ca lower third oesophagus 8
ca lower third esophagus 8
carcinoma of oesophagus 8
carcinoma of esophagus 8
esophageal neoplasms 60
cancer of oesophagus 8
malignant neoplasms 60
cancer of esophagus 8


External Ids:

Disease Ontology8 DOID:5041, DOID:1107
MeSH34 D004938
NCIt39 C3028, C3513
OMIM46 133239
ICD10 via Orphanet26 C15
SNOMED-CT via Orphanet57 372138000, 276804009
UMLS via Orphanet61 C0152018
ICD1025 C15, C15.4, C15.5

Related Diseases for Esophageal Cancer

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Esophageal Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 756)
idRelated DiseaseScoreTop Affiliating Genes
1nasopharynx carcinoma30.9BAX, CDK4, GSTM1, TGFBR2
2lung cancer30.8CCND1, IFI27, TOP1, BAX, CDK4, GSTM1
3squamous cell carcinoma30.7KLF4, CCND1, IFI27, TOP1, BAX, CDK4
4adenocarcinoma30.6KLF4, CCND1, IFI27, TOP1, BAX, CDK4
5non-small cell lung carcinoma30.5CCND1, IFI27, TOP1, BAX, CDK4, GSTM1
6lung small cell carcinoma30.5TOP1, BAX, GSTM1, TGFBR2
7cervical cancer30.4IFI27, BAX, GSTM1
8gallbladder cancer30.4TGFBR2
9colon cancer30.4CCND1, TOP1, BAX, CDK4, TGFBR2
10breast cancer30.3KLF4, CCND1, IFI27, TOP1, BAX, CDK4
11colorectal cancer30.3CCND1, IFI27, TOP1, BAX, CDK4, TGFBR2
12retinoblastoma30.3TGFBR2, CDK4, BAX, IFI27, CCND1
13laryngeal squamous cell carcinoma30.3CCND1, IFI27, BAX, GSTM1, TGFBR2
14leiomyoma30.3TGFBR2
15endometrial carcinoma30.1CCND1, IFI27, BAX, CDK4, TGFBR2
16myeloid leukemia30.1TOP1, BAX, CDK4
17rectal neoplasm30.1BAX, IFI27
18hepatoblastoma30.1TOP1
19pancreatic cancer30.1KLF4, CCND1, IFI27, TOP1, BAX, CDK4
20ovarian cancer30.0CCND1, IFI27, TOP1, BAX, CDK4, TGFBR2
21multiple myeloma30.0CCND1
22bladder carcinoma30.0BAX
23leiomyosarcoma30.0CDK4
24burkitt's lymphoma30.0CDK4, BAX, IFI27
25melanoma29.9CCND1, IFI27, TOP1, BAX, CDK4
26transitional cell carcinoma29.8IFI27, GSTM1, TGFBR2
27prostate cancer29.8BAX, TOP1, IFI27, CCND1, CDK4, DLC1
28leukemia29.8KLF4, CCND1, IFI27, TOP1, BAX, CDK4
29hepatocellular carcinoma29.8CCND1, IFI27, BAX, CDK4, DLC1, GSTM1
30lung adenocarcinoma29.8CCND1, TOP1, BAX, GSTM1, TGFBR2
31stomach cancer29.8CCND1, IFI27, BAX, TGFBR2
32esophageal squamous cell carcinoma29.8LZTS1, DEC1
33acute leukemia29.8GSTM1, TOP1
34thyroid cancer29.8GSTM1, CCND1
35gastric adenocarcinoma29.8GSTM1, BAX, KLF4
36sarcoma29.8GSTM1, CDK4, TOP1
37colon adenocarcinoma29.8BAX, TOP1
38medulloblastoma29.8CDK4, TOP1
39ductal carcinoma in situ29.8CCND1
40esophagitis11.4
41gastric squamous cell carcinoma11.0
42lymph node cancer10.7
43tongue cancer10.6
44thoracic cancer10.6
45gastric cardia adenocarcinoma10.6
46lip cancer10.6
47squamous cell papilloma10.5
48barrett's esophagus10.5
49lung squamous cell carcinoma10.5
50vascular cancer10.5

Graphical network of the top 20 diseases related to Esophageal Cancer:



Diseases related to esophageal cancer

Clinical Features for Esophageal Cancer

About this section
Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

133239

Symptoms:

48 (show all 14)
  • lymphadenopathy/polyadenopathies
  • abnormal cry/voice/phonation disorder/nasal speech
  • chronic hiccup
  • cough
  • thoracic/chest pain
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • anomalies of the neck
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • esophageal neoplasm/tumor/carcinoma/cancer
  • endobrachyesophagus/barrett esophagus
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • generalized obesity
  • intestinal/colonic anomaly

Drugs & Therapeutics for Esophageal Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Esophageal Cancer

Drug clinical trials:

Search ClinicalTrials for Esophageal Cancer

Search NIH Clinical Center for Esophageal Cancer

Search CenterWatch for Esophageal Cancer

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Esophageal Cancer

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Anatomical Context for Esophageal Cancer

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Esophageal Cancer:

32
Lymph node, Lung, Testes, Endothelial, Colon, Testis, T cells, Breast, Liver, Brain, Bone marrow, Bone, Prostate, Thyroid, Whole blood, Heart, Skeletal muscle, Pituitary

FMA organs/tissues related to Esophageal Cancer:

14
The esophagus

Animal Models for Esophageal Cancer or affiliated genes

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Publications for Esophageal Cancer

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Sources:
50PubMed
See all sources

Articles related to Esophageal Cancer:

(show top 50)    (show all 1400)
idTitleAuthorsYear
1
The feasibility of endoscopic submucosal dissection for superficial esophageal cancer in patients with cirrhosis (with video). (24388281)
2014
2
Salvage radiation therapy and chemoradiation therapy for postoperative locoregional recurrence of esophageal cancer. (23551708)
2014
3
Consumption of red and processed meat and esophageal cancer risk: meta-analysis. (23467465)
2013
4
MiR-196a2 rs11614913 T > C polymorphism and risk of esophageal cancer in a Chinese population. (23792053)
2013
5
Successful resection of esophageal cancer with right aortic arch by video-assisted thoracoscopic surgery: a case report. (23564808)
2013
6
Serum tissue inhibitor of metalloproteinase 1 (TIMP-1) and vascular endothelial growth factor A (VEGF-A) are associated with prognosis in esophageal cancer patients. (23773968)
2013
7
Characteristics of recurrence after radical esophagectomy with two-field lymph node dissection for thoracic esophageal cancer. (23255948)
2013
8
Racial disparities in esophageal cancer outcomes. (23263780)
2013
9
Early diagnosis and management of esophageal and gastric cancer. (24212354)
2013
10
Effects of cyclin E gene silencing on the proliferation of esophageal cancer cell lines, EC9706, Eca109 and KYSE30. (23338900)
2013
11
Reversal of multidrug resistance by the anti-malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line. (24179544)
2013
12
Management of gastric epithelial neoplasia in patients requiring esophagectomy for esophageal cancer. (23237403)
2013
13
Statins are associated with reduced risk of esophageal cancer, particularly in patients with Barrett's esophagus: a systematic review and meta-analysis. (23357487)
2013
14
Advances in esophageal surgery in elderly patients with thoracic esophageal cancer. (23564809)
2013
15
Nonsynonymous polymorphisms in FAT4 gene are associated with the risk of esophageal cancer in an Eastern Chinese population. (23319386)
2013
16
Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer. (22992863)
2012
17
Initial results of minimally invasive Ivor Lewis esophagectomy after induction chemoradiation (50.4 gy) for esophageal cancer. (23422805)
2012
18
The -938A/A genotype of BCL2 gene is associated with esophageal cancer. (22187149)
2012
19
Green tea consumption and risk of esophageal cancer: a meta-analysis of epidemiologic studies. (23170950)
2012
20
Expression of MICA/B protein in esophageal cancer and its clinical significance]. (23291067)
2012
21
The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer. (21340746)
2011
22
Expression of cystatin C in human esophageal cancer. (21617716)
2011
23
Overexpression of miR-200c induces chemoresistance in esophageal cancers mediated through activation of the Akt signaling pathway. (21248297)
2011
24
Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China. (21157980)
2010
25
OGG1 Ser326Cys polymorphism and susceptibility to esophageal cancer in low and high at-risk populations of northern India. (20069464)
2010
26
Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses. (19427967)
2009
27
Single nucleotide polymorphism in esophageal cancer related gene 1: an analysis in resected oral squamous cell carcinoma patients. (19394797)
2009
28
Selection of a novel drug-response predictor in esophageal cancer: a novel screening method using microarray and identification of IFITM1 as a potent marker gene of CDDP response. (18202764)
2008
29
Association of interleukin-6 (-174G>C) promoter polymorphism with risk of squamous cell esophageal cancer and tumor location: an exploratory study. (18502691)
2008
30
Impact of VEGF and VEGF receptor 1 (FLT1) expression on the prognosis of stage III esophageal cancer patients after radiochemotherapy. (18956519)
2008
31
Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. (17099870)
2007
32
Screening of differentially expressed proteins from human esophageal cancer and esophageal tissues by two-dimensional difference gel electrophoresis and mass spectrometry]. (17884789)
2007
33
Identification of EGFR mutations in esophageal cancer. (17142003)
2007
34
Glutathione-S-transferase M1 polymorphisms on the susceptibility to esophageal cancer among three Chinese minorities: Kazakh, Tajik and Uygur. (17203516)
2006
35
Genetic susceptibility and environmental factors of esophageal cancer in Xi'an. (15052670)
2004
36
Flow cytometric detection and significance of four cyclins in esophageal cancer]. (15634523)
2004
37
The expressions of p21 and pRB may be good indicators for the sensitivity of esophageal squamous cell cancers to CPT-11: Cell proliferation activity correlates with the effect of CPT-11. (15132777)
2004
38
p53 gene polymorphism with susceptibility to esophageal cancer and lung cancer in Chinese population]. (12921568)
2003
39
The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer]. (14669229)
2003
40
Genetic polymorphisms and susceptibility to esophageal cancer among Chinese population (review). (12883749)
2003
41
Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an. (11833070)
2002
42
Dietary protective and risk factors for esophageal and stomach cancers in a low-epidemic area for stomach cancer in Jiangsu Province, China: comparison with those in a high-epidemic area. (11714439)
2001
43
CPT-11 may provide therapeutic efficacy for esophageal squamous cell cancer and the effects correlate with the level of DNA topoisomerase I protein. (11749700)
2001
44
Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC. (11705871)
2001
45
Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer. (10955802)
2000
46
Expression of p53, bcl-2, and bax as predictors of response to radiotherapy in esophageal cancer. (11206630)
2000
47
Anti-p53 antibodies in patients with Barrett's esophagus or esophageal carcinoma can predate cancer diagnosis. (9649454)
1998
48
Prognostic factors of esophageal cancer]. (9838901)
1998
49
Up-regulation of Fas (APO-1/CD95) ligand and down-regulation of Fas expression in human esophageal cancer. (9605741)
1998
50
Effect of suramin on human esophageal cancer cells in vitro and in vivo. (9282976)
1997

Genetic Variations for Esophageal Cancer

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Esophageal Cancer:

62
id Symbol AA change Variation ID SNP ID
1TGFBR2p.Glu526GlnVAR_015816

Expression for genes affiliated with Esophageal Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Esophageal Cancer

Search GEO for disease gene expression data for Esophageal Cancer.

Pathways for genes affiliated with Esophageal Cancer

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Sources:
29KEGG, 37NCBI BioSystems Database, 55SinoBiological, 51QIAGEN
See all sources

Pathways related to Esophageal Cancer according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0TGFBR2, CDK4, BAX, CCND1
211.0TGFBR2, CDK4, BAX, CCND1
311.0TGFBR2, CDK4, BAX, CCND1
411.0CCND1, TOP1, BAX, CDK4
5
Hide members
10.9TGFBR2, CDK4, CCND1
6
Hide members
10.9CCND1, BAX, CDK4
7
Hide members
10.9CCND1, BAX, CDK4
8
Hide members
10.9CDK4, BAX, CCND1

Compounds for genes affiliated with Esophageal Cancer

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
See all sources

Compounds related to Esophageal Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1thymidylate4411.7TOP1, IFI27, CCND1, BAX, CDK4, GSTM1
2doxorubicin44 49 1113.7GSTM1, TOP1, IFI27, CCND1, BAX, CDK4
3cisplatin44 49 59 1114.7CDK4, GSTM1, IFI27, CCND1, BAX, TOP1
4eb 108944 5912.6CCND1, TGFBR2, CDK4, BAX, IFI27
5adpribose4411.6CDK4, CCND1, IFI27, TOP1, BAX
6paclitaxel44 49 1113.5CCND1, IFI27, BAX, TOP1, CDK4
7pd 98,0594411.5CDK4, CCND1, KLF4, BAX, IFI27
8ly2940024411.5CDK4, BAX, IFI27, CCND1, TGFBR2
9n-(4-hydroxyphenyl)retinamide4411.5CCND1, BAX, TGFBR2, CDK4
10indole-3-carbinol4411.5CCND1, CDK4, BAX, IFI27
11cycloheximide4411.5CCND1, TGFBR2, TOP1, BAX, CDK4
12flavopiridol44 1112.4BAX, CDK4, CCND1, TOP1
13gefitinib44 49 1113.4CCND1, IFI27, CDK4, TOP1
14vincristine44 49 1113.4BAX, CCND1, GSTM1, TOP1
15troglitazone44 28 59 1114.4CDK4, BAX, IFI27, CCND1
16quercetin44 59 11 2414.4CCND1, CDK4, BAX, IFI27
175fluorouracil4411.4GSTM1, CDK4, BAX, TOP1
18retinoid4411.4CDK4, BAX, IFI27, CCND1
19ursolic acid4411.3CCND1, BAX, TOP1
20norcantharidin4411.3IFI27, CCND1, BAX
21gossypol4411.3CCND1, BAX, CDK4
22n acetylcysteine4411.3BAX, CCND1, IFI27, CDK4
23apigenin44 2812.3BAX, CDK4, CCND1
24olomoucine44 1112.3BAX, CCND1, CDK4
25lycopene44 2412.3CCND1, CDK4, IFI27
26sulindac44 1112.3IFI27, CCND1, BAX
27sulforaphane4411.2CCND1, GSTM1, BAX
28roscovitine4411.2CDK4, IFI27, CCND1
29trastuzumab44 49 1113.2CDK4, CCND1, IFI27
30tamoxifen44 49 28 1114.2TGFBR2, CCND1, IFI27, BAX
31bortezomib44 1112.2CCND1, TOP1, BAX
32carboplatin44 49 1113.2TOP1, GSTM1, CDK4
33inostamycin4411.2BAX, CCND1
34dl 111it4411.2CDK4, CCND1
35optimax4411.1CCND1, IFI27
36vitamin d4411.1CDK4, TGFBR2, GSTM1, IFI27
37bleomycin44 1112.1GSTM1, TGFBR2, TOP1
38pga24411.1CDK4, CCND1
39pyrene4411.1CDK4, GSTM1
40ag-1264411.0CCND1, CDK4
414,6-diamidino-2-phenylindole4411.0TOP1, BAX
42berberine4411.0CCND1, CDK4
43depsipeptide4411.0CCND1
4410-hydroxycamptothecin4411.0TOP1, BAX
45gemcitabine44 49 1112.9TOP1, BAX, CCND1
46beta-lapachone4410.9BAX, TOP1
47lovastatin44 49 59 28 1114.8CCND1, CDK4, IFI27
48ginsenoside4410.7CCND1, BAX
49vitamin k24410.7BAX, CDK4
50sp 60012544 5911.6CCND1, BAX, CDK4

GO Terms for genes affiliated with Esophageal Cancer

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Sources:
16Gene Ontology
See all sources

Cellular components related to Esophageal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:00030710.7CDK4, CCND1

Biological processes related to Esophageal Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to drugGO:04249311.0TGFBR2, CDK4, TOP1, CCND1
2organ regenerationGO:03110010.8TGFBR2, CDK4, CCND1
3activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.6IFI27, BAX, DLC1

Products for genes affiliated with Esophageal Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophageal Cancer

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet