Esophageal Carcinoma malady

Wikipedia: Esophageal cancer (or oesophageal cancer) is malignancy of the esophagus. There are various subtypes,...⁴⁴ more...

MalaCards: Esophageal Carcinoma, also known as carcinoma of esophagus (disorder), is related to renal cell carcinoma and basal cell carcinoma. An important gene associated with Esophageal Carcinoma is FZD7 (frizzled family receptor 7), and among its related pathways are Signal transduction_PTEN pathway and Cell Cycle / Checkpoint Control. The drugs carmustine and diethylstilbestrol diphosphate and the compounds lovastatin and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include the esophagus, bone marrow and lymph node, and related mouse phenotypes are hematopoietic system and respiratory system.

Disease Ontology: A esophageal cancer that is located in the esophagus.⁶

Aliases & Descriptions:

esophageal carcinoma 6 7 8 32 43 carcinoma of esophagus (disorder) 6 carcinoma of oesophagus 6 carcinoma of esophagus 6

cancer of oesophagus 6 malignant neoplasms 43 cancer of esophagus 6 carcinoma 43

Diseases related to esophageal carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1872)

id	Related Disease	Score	Top Affiliating Genes
1	renal cell carcinoma	39.0	KIT, PCNA, VEGFA, VEGFC, RARB, BIRC5
2	basal cell carcinoma	37.8	LGALS1, BAX, S100A2, JUP, CD34, CD44
3	papillary thyroid carcinoma	37.3	SERPINB5, VEGFC, RARB, MUC4, BAX, CD44
4	hepatitis	36.9	GSR, FASLG, FAS, IFNA1, IFNA2, HLA-A
5	neuroendocrine carcinoma	35.7	KIT, CEACAM5, FSCN1, CDH2, CDH1, MMP7
6	adenoid cystic carcinoma	35.6	KIT, PCNA, SERPINB5, CEACAM3, CDH1, MKI67
7	non-small cell lung carcinoma	35.3	PCNA, RB1, VEGFA, VEGFC, MYC, BIRC5
8	hepatitis b	34.9	MRPL28, IL18, IL2RA, IFNA1, IFNA2, CAT
9	esophagitis	34.9	ZNF207, RELN, KIT, VSIG1, PCNA, RB1
10	tongue cancer	34.8	VEGFC, BCL2L1, LGALS1, CDKN1A, CDH1, MMP2
11	mucoepidermoid carcinoma	34.8	PCNA, MUC4, CEACAM5, CDKN1B, MKI67, TP63
12	squamous cell carcinoma of the head and neck	34.2	RB1, VEGFA, VEGFC, MYC, RARB, BIRC5
13	clear cell renal cell carcinoma	34.0	KIT, VEGFA, VEGFC, MYC, BIRC5, MT1G
14	endometrial carcinoma	33.9	KIT, PCNA, RB1, SERPINB5, VEGFA, VEGFC
15	merkel cell carcinoma	33.9	KIT, PCNA, VEGFC, BIRC5, BAX, CEACAM3
16	chromophobe renal cell carcinoma	33.8	KIT, PCNA, RARB, MAGEA3, MAGEA4, CCND1
17	carcinoma	33.7	ZNF207, RELN, KIT, VSIG1, PCNA, RB1
18	papillary renal cell carcinoma	33.6	KIT, PCNA, VEGFA, VEGFC, CD44, MMP11
19	nasopharynx carcinoma	33.6	VEGFA, CD79A, CDKN2A, CDH1, MMP9, CCND1
20	adrenocortical carcinoma	33.5	RB1, CDH2, FGF2, FAS, MAPK3, ERCC1
21	oral squamous cell carcinoma	33.3	PCNA, RB1, RBL2, SERPINB5, VEGFA, VEGFC
22	renal oncocytoma	33.3	KIT, PCNA, MAGEA3, MAGEA4, CCND1, TP53
23	adenosquamous carcinoma	33.3	KIT, PCNA, CEACAM5, CDKN2A, MKI67, TP53
24	ovarian carcinoma	33.1	KIT, PCNA, RB1, RBL2, SERPINB5, VEGFA
25	laryngeal squamous cell carcinoma	33.1	PCNA, RB1, VEGFA, VEGFC, MYC, BIRC5
26	hepatitis c	33.1	MMP1, GSR, IL18, IL6R, FAS, IFNA1
27	breast carcinoma	32.9	KIT, PCNA, RB1, RBL2, SERPINB5, VEGFA
28	prostatitis	32.8	RELN, KIT, PCNA, RB1, RBL2, SERPINB5
29	liver cirrhosis	32.7	ATP7B, CD34, MMP3, MAGEA1, MAGEA4, IFNA1
30	colorectal adenoma and carcinoma	32.6	PCNA, VEGFA, CHEK2, BAX, CEACAM5, JUP
31	thymic carcinoma	32.6	KIT, VEGFC, CEACAM5, CEACAM3, TP63, PTGS2
32	pleomorphic carcinoma	32.4	FSCN1, CDKN1B, TP53, CRP, PDPN, KRT8
33	skin carcinoma	32.3	JUP, CDK4, CDH1, MMP2, GSTM1, GSTP1
34	collecting duct carcinoma	32.3	CEACAM3, CDKN1B, FHIT, KRT19, TOP1, AFP
35	ovarian cancer	32.3	RB1, RBL2, CHEK2, CDKN1A, CDKN2B, CDKN1B
36	keratoacanthoma	32.3	PCNA, BCL2L1, MSH2, JUP, CDKN1A, CD44
37	pleomorphic adenoma	32.3	PCNA, SERPINB5, CDKN1B, MDM2, ERBB2, TP63
38	keratosis	32.2	PCNA, RB1, MYC, S100A2, CEACAM5, JUP
39	colon carcinoma	32.2	KIT, VEGFA, MYC, BMP6, RARB, BIRC5
40	thyroiditis	32.2	RELN, KIT, PCNA, RB1, RBL2, SERPINB5
41	basaloid squamous cell carcinoma	32.2	PCNA, MYC, BIRC5, BCL2L1, BAX, CD79A
42	bile duct carcinoma	32.2	KIT, VEGFC, MYC, MUC4, FSCN1, CDKN2A
43	bladder carcinoma	32.1	PCNA, RB1, RBL2, SERPINB5, VEGFA, VEGFC
44	renal clear cell carcinoma	32.0	VEGFA, BMI1, BIRC5, CDKN1B, CD44, CDH1
45	salivary gland cancer	31.9	KIT, SERPINB5, BIRC5, MMP13, MMP9, FAS
46	colorectal cancer	31.9	CHEK2, MSH2, MLH1, GSTM1, GSTP1, GSTT1
47	cervical squamous cell carcinoma	31.8	MYC, BIRC5, BAX, CEACAM5, CDKN1A, CDKN1B
48	oral cavity cancer	31.7	VEGFA, BAX, GSTM1, GSTT1, IL18, MAPK14
49	actinic keratosis	31.7	PCNA, RB1, MYC, S100A2, CEACAM5, CDKN2B
50	trichoepithelioma	31.7	CDKN2B, CD34, CDH1, MMP11, MKI67, PDPN

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, nilutamide

MalaCards organs/tissues related to esophageal carcinoma:

²²

FMA organs/tissues related to esophageal carcinoma:

¹¹

MGI Mouse Phenotypes related to esophageal carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.2	KIT, PCNA, BMI1, BCL2L1, ZBTB17, CHEK2
2	respiratory system phenotype	MP:0005388	10.8	MT2A, CASK, TP63, PDGFB, ACVR2B, STAT5B
3	endocrine/exocrine gland phenotype	MP:0005379	10.8	RBL2, FZD4, FZD5, CDKN2B, CDKN1B, FGF8
4	craniofacial phenotype	MP:0005382	10.4	KIT, BMI1, FZD1, FZD2, INHBA, FGF8
5	embryogenesis phenotype	MP:0005380	10.3	KIT, RBL2, SERPINB5, MYC, BMI1, RARB
6	renal/urinary system phenotype	MP:0005367	10.0	KIT, MYLK, RARB, BAX, MT2A, FZD4
7	immune system phenotype	MP:0005387	10.0	KIT, MYLK, BMI1, LGALS1, ZBTB17, CHEK2
8	normal phenotype	MP:0002873	9.9	RBL2, VEGFA, MYC, MYLK, RARB, LGALS1
9	pigmentation phenotype	MP:0001186	9.9	KIT, RB1, MYC, ZBTB17, ATP7B, FZD4
10	integument phenotype	MP:0010771	9.9	RELN, KIT, RB1, RBL2, MYC, CLOCK
11	nervous system phenotype	MP:0003631	9.7	RELN, KIT, RB1, RBL2, VCP, MYC
12	other phenotype	MP:0005395	9.7	RARB, ATP7B, CDKN2A, ITGA6, MMP14, GJA1
13	no phenotypic analysis	MP:0003012	9.6	PCNA, RB1, RBL2, VEGFA, MYC, CLOCK
14	mortality/aging	MP:0010768	9.5	RELN, RB1, RBL2, SERPINB5, VEGFA, VEGFC
15	liver/biliary system phenotype	MP:0005370	9.5	KIT, VEGFA, CLOCK, MT2A, ATP7B, IL6
16	limbs/digits/tail phenotype	MP:0005371	9.4	KIT, RB1, RBL2, VEGFA, BMI1, RARB
17	behavior/neurological phenotype	MP:0005386	9.1	RELN, KIT, RB1, VCP, MYLK, BMI1
18	hearing/vestibular/ear phenotype	MP:0005377	8.7	KIT, RB1, MYC, RARB, BAX, FZD1
19	growth/size phenotype	MP:0005378	8.7	RELN, KIT, RB1, RBL2, MYC, MYLK
20	digestive/alimentary phenotype	MP:0005381	8.5	RELN, KIT, RB1, VEGFA, MYC, MYLK
21	reproductive system phenotype	MP:0005389	7.9	RBL2, VEGFA, RARB, CLOCK, CHEK1, MT2A
22	skeleton phenotype	MP:0005390	7.9	KIT, RB1, RBL2, VEGFA, VCP, MYC
23	vision/eye phenotype	MP:0005391	7.5	RELN, KIT, RB1, RBL2, VEGFA, BMI1
24	adipose tissue phenotype	MP:0005375	7.4	RB1, MYC, CLOCK, CDKN1A, CDKN1B, FIGF
25	tumorigenesis	MP:0002006	6.9	KIT, RB1, RBL2, MYC, BMI1, BCL2L1
26	homeostasis/metabolism phenotype	MP:0005376	6.5	KIT, RB1, RBL2, VEGFA, VEGFC, MYC
27	cellular phenotype	MP:0005384	6.1	RELN, KIT, PCNA, RB1, RBL2, SERPINB5
28	muscle phenotype	MP:0005369	6.0	RELN, KIT, RB1, RBL2, VEGFA, VCP
29	cardiovascular system phenotype	MP:0005385	5.8	KIT, RB1, RBL2, VEGFA, VEGFC, MYC

Articles related to esophageal carcinoma:

(show top 50)    (show all 237)

id	Title	Authors	Year	Affiliating Genes
1	Insulin-like growth factor 1 mediates 5-fluorouracil chemoresistance in esophageal carcinoma cells through increasing survivin stabi lity. (21082354)	Juan H.C.... Wong F.H.	2011	IGF1, BIRC5
2	The PTEN/PI3K/Akt pathway regulates stem-like cells i n primary esophageal carcinoma cells. (21467840)	Li H.... Lu S.H.	2011	PTEN
3	Notch1 signaling inhibits growth of EC109 esophageal carcinoma cells through downmodulation of HPV18 E6/E7 gene expression. (19122673)	Zhang K.J.... Liu W.L.	2009	NOTCH1
4	Detachment of esophageal carcinoma cells from extracellular matrix causes relocalization of death receptor 5 and apoptosis. (19230044)	Liu G.C.... Ma Y.F.	2009	TNFRSF10B
5	Dendritic cell-tumor cell fusion vaccine prevents gr owth of subcutaneous transplanted esophageal carcinomas (19799815)	Deng Y.J.... Xia J.C.	2009	MRPL28
6	In vivo antitumor effect of canstatin gene on human esophageal carcinoma xenografts in nude mice (19622292)	Zheng X.W.... Lu G.F.	2009	CASP3, COL4A2
7	Effects of Oxymatrine on the apoptosis of human esophageal carcinoma Eca109 cell line and its mechanism. (18563331)	Jin Y.... Chen Y.	2008	BAX
8	TM4SF3 promotes esophageal carcinoma metastasis via upregulating ADAM12m expression. (18365756)	Zhou Z.... Yang Z.H.	2008	ADAM12, TSPAN8
9	Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. (17943723)	Leung A.C.... Lung M.L.	2008	DEC1
10	Prognostic significance of RCAS1 expression in relation to the infiltration of dendritic cells and lymphocytes in patients with esophageal carcinoma. (17211709)	Tsujitani S.... Ikeguchi M.	2007	EBAG9
11	Expression level of hepatoma-derived growth factor correlates with tumor recurrence of esophageal carcinoma. (17473954)	Yamamoto S.... Monden M.	2007	HDGF
12	Relationship between biomarker expression and allelic alteration in esophageal carcinoma. (18031395)	Vegh I.... Moreno-GonzA!lez E.	2007	MMP1
13	ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells. (16380648)	Zhao N.... Lu S.H.	2006	ZBTB17
14	Inhibition of peroxisome proliferator-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties. (16805824)	Takahashi H.... Nakajima A.	2006	PPARG
15	Gefitinib-sensitizing mutations in esophageal carcinoma. (16707764)	Guo M.... Lu F.	2006	EGFR
16	Expression of CD80, CD86, TGF-beta1 and IL-10 mRNA in the esophageal carcinoma (17366789)	Yang W.F.... Wang S.Z.	2006	CD86, CD80
17	Correlation of p73 polymorphisms to genetic susceptibilities to esophageal carcinoma and gastric cardiac carcinoma (17094900)	Ge H.... Zhang J.H.	2006	TP73
18	Newly developed assay measuring cytokeratins 8, 18 and 19 in serum is correlated to survival and tumor volume in patients with esophageal carcinoma. (16197528)	Brattstrom D.... Bergqvist M.	2005	KRT8
19	Expressions of epithelial growth factor receptor and E-cadherin in esophageal carcinoma and their correlation (15694044)	Fu J.H.... Hu G.Q.	2005	EGFR, CDH1
20	Expression and significance of heat shock protein 70 and glucose-regulated protein 94 in human esophageal carcinoma. (15637761)	Wang X.P.... Liu Y.	2005	HSP90B1
21	p53 gene mutation and human papillomavirus (HPV) infection in esophageal carcinoma from three different endemic geographic regions of India. (15639342)	Katiyar S.... Das B.C.	2005	TP53
22	LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China. (15774487)	Cao B.... Ke Y.	2005	PSMB8, TAP2
23	Downregulation of survivin by RNAi inhibits the growt h of esophageal carcinoma cells. (16082195)	Wang Y.... Xu N.	2005	BIRC5
24	The ligands of peroxisome proliferator-activated rece ptor (PPAR) gamma inhibit growth of human esophageal carcinoma cells through in duction of apoptosis and cell cycle arrest. (15274302)	Fujii D.... Toge T.	2004	PPARG
25	Inhibition of adenovirus-mediated p27kip1 gene on growth of esophageal carcinoma cell strain. (14606065)	Wu Q.M.... Xie G.J.	2003	CDKN1B
26	Expression of copper-transporting P-type adenosine triphosphatase in human esophageal carcinoma. (12579336)	Higashimoto M.... Takebayashi Y.	2003	ATP7B
27	Functions of neutrophil gelatinase-associated lipocalin in the esophageal carcinoma cell line SHEEC (12621549)	Li E.M.... Zeng Y.	2003	LCN2
28	Cloning and identification of 5'-untranslated region (UTR) and 3'-untranslated region of neutrophil gelatinase-associated lipocalin (NGAL) gene from esophageal carcinoma cell line SHEEC (12600287)	Li E.M.... Shen Z.Y.	2003	LCN2
29	Expression and hypoxic regulation of vascular endothelial growth factor and matrix metalloproteinase-9 in esophageal carcinoma (11977637)	Guo W.... Yang Z.	2002	MMP9
30	Cyclin D1 expression is useful as a prognostic indicator for advanced esophageal carcinomas, but not for superficial tumors. (10795746)	Toyoda H.... Nakamura S.	2000	CCND1
31	A phase II trial of topotecan in esophageal carcinoma: a Southwest Oncology Group study (SWOG 9339). (10857998)	Macdonald J.S.... Conrad M.	2000	TOP1
32	Expression of p53 and p21 is useful for the prediction of preoperative chemotherapeutic effects in esophageal carcinoma. (10928129)	Nakashima S.... Aikou T.	2000	TP53
33	Clinical significance of matrix metalloproteinase-7 expression in esophageal carcinoma. (10741748)	Yamashita K.... Sugimachi K.	2000	MMP7
34	Prognostic significance of polo-like kinase expression in esophageal carcinoma. (10493949)	Tokumitsu Y.... Niho Y.	1999	PLK1, MYLK
35	Phase II clinical trial of 13-cis-retinoic acid and i nterferon-alpha-2a in patients with advanced esophageal carcinoma. (10189124)	Enzinger P.C.... Kelsen D.P.	1999	IFNA2, IFNA1
36	Analysis of macroscopic appearance and p53 expression in superficial esophageal carcinoma. (10522005)	Natsugoe S.... Aikou T.	1999	TP53
37	A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. (9707618)	Tanaka S.... Sugimachi K.	1998	APC, FZD9, FZD7
38	Expression of mdr-1 gene in cancer tissue and its association with morphological indexes of esophageal carcinoma (10923514)	Chen K.... Cheng B.	1998	ABCB1
39	p53 protein accumulation and p53 gene mutation in esophageal carcinoma. A molecular and immunohistochemical study with clinicopathologic correlations. (9028350)	Coggi G.... Peracchia A.	1997	TP53
40	Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. (8988034)	Tanaka S.... Sugimachi K.	1997	GRB7
41	Expression of E-cadherin, alpha-catenin, beta-catenin and plakoglobin in esophageal carcinomas and its prognostic significance: immunohistochemical analysis of 96 lesions. (9075789)	Nakanishi Y.... Hirohashi S.	1997	CTNNB1, JUP, CTNNA1
42	Effect of hyperthermia on proliferation and deviation of carcinoembryonic antigen and squamous cell carcinoma-related antigen of human esophageal carcinoma cells in culture. (9183632)	Saito M.... Saito H.	1996	PSG2
43	Expression of p53 protein related to human papillomavirus and DNA ploidy in superficial esophageal carcinoma. (7549269)	Nakamura T.... Maeda S.	1995	TP53
44	A phase II trial of interferon alpha-2A, 5-fluorouracil, and cisplatin in patients with advanced esophageal carcinoma. (7712428)	Ilson D.H.... Kelsen D.P.	1995	IFNA2, IFNA1
45	A unique p53 intragenic deletion flanked by short direct repeats results in loss of mRNA expression in a human esophageal carcinoma. (8055646)	Huang Y.... Meltzer S.J.	1994	TP53
46	Intratumoral heterogeneity of DNA ploidy and regional differences in epidermal growth factor and epidermal growth factor receptor of esophageal carcinoma. (8128479)	Deguchi S.... Toda T.	1993	EGF
47	Altered messenger RNA and unique mutational profiles of p53 and Rb in human esophageal carcinomas. (8467510)	Huang Y.... Zou Z.Q.	1993	TP53, RB1
48	Overexpression of p53 protein in human spontaneous esophageal carcinoma and fetal esophageal carcinoma induced by N-methyl-N-benzylnitrosamine (NMBzA) (1396069)	Guo Y.J.	1992	TP53
49	TAF test in primary esophageal carcinoma: comparison with other tumor markers. (1665164)	Taccone W.... Dei Poli M.	1991	SPINK1
50	EGF and TGF-alpha, the ligands of hyperproduced EGFR in human esophageal carcinoma cells, act as autocrine growth factors. (2298497)	Yoshida K.... Tahara E.	1990	EGF, TGFA

Genes related to esophageal carcinoma according to GeneCards:

(show top 50)    (show all 239)

id	Symbol	Description	Score	GeneCards Section Context
1	FZD7	frizzled family receptor 7	11.1	Publications, Expressions, Summaries
2	DCC	deleted in colorectal carcinoma	11.1	Summaries
3	RNF6	ring finger protein (C3H2C3 type) 6	11.0
4	SPINK7	serine peptidase inhibitor, Kazal type 7 (putative)	11.0	Publications
5	CTAG2	cancer/testis antigen 2	11.0	Publications
6	GRB7	growth factor receptor-bound protein 7	11.0	Functions, Publications
7	SPRR3	small proline-rich protein 3	11.0
8	MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	11.0	Publications
9	CTAG1B	cancer/testis antigen 1B	11.0	Publications
10	SPINK1	serine peptidase inhibitor, Kazal type 1	11.0	Publications
11	MAGEA4	melanoma antigen family A, 4	11.0	Publications
12	INHBA	inhibin, beta A	11.0	Publications
13	HPSE	heparanase	11.0	Publications
14	FGF4	fibroblast growth factor 4	11.0
15	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0	Publications
16	MMP11	matrix metallopeptidase 11 (stromelysin 3)	11.0	Publications
17	MAGEA3	melanoma antigen family A, 3	11.0	Publications
18	FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	11.0
19	LCN2	lipocalin 2	11.0	Publications
20	DSG1	desmoglein 1	11.0	Publications
21	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
22	IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	11.0	Publications
23	CD80	CD80 molecule	11.0	Publications
24	CD86	CD86 molecule	11.0	Publications
25	EGR1	early growth response 1	11.0	Publications
26	KRT14	keratin 14	11.0
27	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
28	JUP	junction plakoglobin	11.0	Publications
29	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
30	POLB	polymerase (DNA directed), beta	11.0	Publications
31	MTA1	metastasis associated 1	11.0
32	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
33	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
34	CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	11.0	Publications
35	CHEK1	checkpoint kinase 1	11.0	Publications
36	CHEK2	checkpoint kinase 2	11.0	Publications
37	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
38	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0
39	GJB2	gap junction protein, beta 2, 26kDa	11.0	Publications
40	MUC4	mucin 4, cell surface associated	11.0
41	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
42	CD46	CD46 molecule, complement regulatory protein	11.0
43	TP53	tumor protein p53	11.0	Publications
44	TP73	tumor protein p73	11.0	Publications
45	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
46	TYMP	thymidine phosphorylase	11.0	Publications
47	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	11.0	Publications
48	CCND1	cyclin D1	11.0	Publications
49	APC	adenomatous polyposis coli	11.0	Publications
50	PCNA	proliferating cell nuclear antigen	11.0	Publications

Pathways related to esophageal carcinoma according to GeneDecks:

(show top 50)    (show all 280)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	11.0	PCNA
2	Cell Cycle / Checkpoint Control3	11.0	PCNA, RB1, VCP, CHEK1, CHEK2, AURKA
3	Glioblastoma Multiforme36	10.9	RB1, FZD1, FZD10, FZD2, FZD4, FZD5
4	Glioma Invasiveness36	10.7	VEGFC, BMP6, CD44, ITGA6, FIGF, FGF2
5	Translation Non-genomic (rapid) action of Androgen Receptor10	10.6	FZD1, FZD10, FZD2, FZD4, FZD5, FZD7
6	Colorectal cancer20	10.5	MSH2, MSH3, MAP2K1, TGFB1, TGFBR2, DCC
7	Non-small cell lung cancer20	10.4	RB1, CDKN2A, CDK4, FHIT, MAP2K2, MAPK1
8	Chronic myeloid leukemia20	10.3	RB1, MYC, BCL2L1, CDKN1A, CDKN1B, CDKN2A
9	Akt Signaling36	10.2	KIT, VEGFC, CHEK1, CD80, ITGA6, FIGF
10	Breast Cancer Regulation by Stathmin136	10.1	FIGF, FGF2, FGF4, FGF8, FGFR2, GRB7
11	Glioma20	10.1	RB1, CDKN1A, CDKN2A, CDK4, MDM2, MAP2K2
12	Melanoma20	9.8	RB1, CDKN1A, CDKN2A, CDK4, CDH1, FGF2
13	Signal transduction PTEN pathway10	9.8	PCNA, CDKN1A, MAP2K2, MAPK3, MAPK1, MAP2K1
14	PTEN Pathway36	9.8	KIT, VEGFC, ITGA6, FIGF, FGF2, FGF4
15	ERK5 Signaling36	9.6	KIT, VEGFC, MYC, BMP6, FIGF, FGF4
16	Prostate cancer20	9.5	RB1, CDKN1A, CDKN1B, GSTP1, FGFR2, MDM2
17	JNK Pathway36	9.4	KIT, BMP6, BAX, CD80, FGF2, FGF4
18	Telomerase Components in Cell Signaling36	9.4	KIT, RB1, VEGFC, MYC, BMP6, FIGF
19	Bladder cancer20	9.1	RB1, VEGFA, VEGFC, MYC, CDKN1A, CDKN2A
20	ILK Signaling36	8.9	KIT, VEGFC, CDH2, CDH1, FIGF, FGF2
21	Transcription Androgen Receptor nuclear signaling10	8.9	FZD1, FZD10, FZD2, FZD4, FZD5, FZD7
22	Transcription_Androgen Receptor nuclear signaling41	8.8	FZD1, FZD10, FZD2, FZD4, FZD5, FZD7
23	p53 Mediated Apoptosis36	8.8	KIT, VEGFC, BMP6, CHEK1, CHEK2, BAX
24	Mitochondrial Apoptosis36	8.7	KIT, VEGFC, BMP6, BCL2L1, CHEK2, BAX
25	eIF2 Pathway36	8.7	KIT, VEGFC, BMP6, FIGF, FGF2, FGF4
26	Rho Family GTPases36	8.6	KIT, VEGFC, MYLK, BMP6, BAX, CDH2
27	Cytokine-cytokine receptor interaction20	8.6	KIT, VEGFA, VEGFC, FIGF, INHBA, IL18
28	Rac1 Pathway36	8.6	BMP6, ITGA6, FIGF, FGF2, FGF4, FGF8
29	ERK Signaling36	8.6	KIT, VEGFC, MYC, MYLK, BMP6, CD80
30	DHA Signaling36	8.5	KIT, VEGFC, BMP6, BCL2L1, BAX, FIGF
31	Pathways in cancer20	8.5	RB1, VEGFA, VEGFC, MYC, RARB, BIRC5
32	Activation of PKC through GPCR36	8.4	KIT, VEGFC, BMP6, FIGF, FGF2, FGF4
33	Apoptotic Pathways in Synovial Fibroblasts36	8.4	KIT, VEGFC, BMP6, FIGF, FGF2, FGF4
34	Cellular Apoptosis Pathway36	8.3	KIT, VEGFC, BMP6, BCL2L1, CHEK2, BAX
35	Nanog in Mammalian ESC Pluripotency36	8.2	KIT, VEGFC, BMP6, FZD1, FZD10, FZD2
36	GSK3 Signaling36	8.2	KIT, VEGFC, BMP6, FZD1, FZD10, FZD2
37	PPAR Pathway36	8.1	KIT, VEGFC, ITGA6, FIGF, FGF2, FGF4
38	Pancreatic Adenocarcinoma36	8.0	KIT, RB1, VEGFC, BMP6, BIRC5, BCL2L1
39	Colorectal Cancer Metastasis36	8.0	MYC, BIRC5, BCL2L1, BAX, MSH2, MSH3
40	p70S6K Signaling36	8.0	KIT, VEGFC, BMP6, FIGF, FGF2, FGF4
41	Estrogen Pathway36	8.0	KIT, VEGFC, BMP6, FIGF, FGF2, FGF4
42	Renin-Angiotensin Pathway36	7.9	KIT, VEGFC, BMP6, FIGF, FGF2, FGF4
43	Phospholipase-C Pathway36	7.9	KIT, VEGFC, BMP6, CD79A, ITGA6, FIGF
44	GPCR Pathway36	7.9	KIT, VEGFC, BMP6, FIGF, FGF2, FGF4
45	TGF-Beta Pathway36	7.8	VEGFC, BMP6, BAX, CD80, CDH1, FIGF
46	Tec Kinases Signaling36	7.8	VEGFC, BMP6, BAX, CD80, ITGA6, FIGF
47	Antioxidant Action of Vitamin-C36	7.7	KIT, VEGFC, BMP6, BAX, CD80, FIGF
48	NFAT in Immune Response36	7.6	KIT, VEGFC, BMP6, CD79A, CD86, CD80
49	Rap1 Pathway36	7.6	VEGFC, BMP6, ITGA6, FIGF, FGF2, FGF4
50	MAPK Signaling36	7.1	KIT, VEGFC, MYC, BMP6, ITGA6, FIGF

Compounds related to esophageal carcinoma according to GeneDecks:

(show top 50)    (show all 428)

id	Compound	Score	Top Affiliating Genes
1	lovastatin32 42 9 9	13.7	RB1, XIAP, CDKN1A, CDKN1B, CDKN2A, CDK4
2	hematoxylin32	10.5	KIT, PCNA, CEACAM5, CEACAM3, CDKN2A, CD34
3	nocodazole32 42 9 9	13.3	BIRC5, CHEK1, CHEK2, ATP7B, CD79A, CDKN1A
4	histamine32 18	11.3	KIT, PCNA, BMP6, CGA, JUP, CD79A
5	cysteine32	10.3	PCNA, RARB, BCL2L1, LGALS1, MT2A, XIAP
6	gp 13032	10.2	KIT, BMP6, BCL2L1, IL2RA, IL6R, IL6ST
7	vitamin a32 9 18 9	13.2	RB1, MYC, RARB, BIRC5, LCN2, CGA
8	progestin32	10.1	VEGFA, CGA, CDK4, CDH1, CCND1, GJA1
9	hyaluronic acid32 18	11.1	MYC, BMP6, CEACAM5, CD44, CDH1, MMP1
10	cytarabine32 34 9 9	13.0	KIT, PCNA, RB1, MYC, BCL2L1, CHEK1
11	epinephrine32 9 18 9	12.8	BMP6, CGA, CD79A, MMP1, MMP2, MMP9
12	retinoid32	9.8	MYC, BMP6, RARB, BCL2L1, LGALS1, BAX
13	temozolomide32 9 9	11.7	PCNA, VEGFA, CHEK1, CHEK2, MSH2, CDKN1A
14	indole-3-carbinol32	9.7	BIRC5, BCL2L1, BAX, XIAP, CDKN1A, CDKN1B
15	n acetylcysteine32	9.6	PCNA, BIRC5, CHEK1, CHEK2, CD79A, CDKN1A
16	aspartate32	9.6	PCNA, MYLK, BMP6, UMPS, CGA, AURKA
17	p00232	9.5	KIT, RB1, SERPINB5, BIRC5, CEACAM5, JUP
18	betacarotene32	9.5	PCNA, RB1, RARB, CD79A, MMP1, GSR
19	atp32	9.4	KIT, RB1, RBL2, VCP, MYLK, BIRC5
20	mg 13232 42	10.3	PCNA, MYC, BIRC5, BCL2L1, BAX, XIAP
21	arginine32	9.3	RARB, LGALS1, CGA, FZD4, CD79A, CDK4
22	topotecan32 9 9	11.3	BIRC5, BCL2L1, CHEK1, GSTP1, IGF1, ERBB2
23	thymidylate32	9.3	PCNA, RB1, VEGFA, BIRC5, BCL2L1, UMPS
24	prostaglandin32	9.2	VEGFC, CGA, CDK4, MMP1, MMP13, MMP3
25	phorbol32	9.2	MYC, CDKN1A, MMP1, MMP2, MMP3, MMP9
26	glutamate32	9.1	PCNA, BMP6, XIAP, MSH2, FZD4, CD79A
27	ndga32	9.0	MMP13, MMP3, IL2RA, CAT, TNF, PTGS2
28	cyclosporin a32 42	10.0	MYC, CGA, CD86, CD80, CDK4, CD44
29	12-o-tetradecanoylphorbol 13-acetate32	9.0	RB1, MYC, BMP6, RARB, FSCN1, CDKN1A
30	gemcitabine32 34 9 9	12.0	PCNA, VEGFA, MYC, BIRC5, BCL2L1, UMPS
31	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	9.0	PCNA, MYC, BCL2L1, BAX, MMP2, MMP9
32	cholesterol32 9 18 9	12.0	RELN, RB1, BIRC5, MUC4, CEACAM5, CEACAM3
33	ag 147832	8.9	CDKN1B, MMP14, MMP2, MMP7, MMP9, FASLG
34	irinotecan32 34 9 9	11.8	KIT, VEGFA, BCL2L1, UMPS, CHEK1, BAX
35	erlotinib32 34 9 9	11.8	KIT, VEGFA, BIRC5, CDKN1B, CDH1, MAPK1
36	folate32	8.8	MYC, MT2A, CGA, FTL, CD79A, CDKN2A
37	resveratrol32 9 18 9	11.6	PCNA, RB1, VEGFA, BIRC5, BCL2L1, BAX
38	etoposide32 42 9 9	11.6	PCNA, RB1, MYC, BIRC5, BCL2L1, LGALS1
39	adriamycin32	8.6	RB1, MYC, BIRC5, BCL2L1, CHEK1, CHEK2
40	thalidomide32 42 9 9	11.5	VEGFA, BIRC5, BCL2L1, XIAP, FGF2, FGFR2
41	gefitinib32 34 9 9	11.4	KIT, VEGFA, BIRC5, BCL2L1, CEACAM5, CDKN1A
42	bortezomib32 9 9	10.3	VEGFA, VCP, MYC, BIRC5, BCL2L1, BAX
43	alanine32	8.3	PCNA, RBL2, MYC, MYLK, BMP6, BIRC5
44	5fluorouracil32	8.2	KIT, PCNA, RB1, VEGFA, BIRC5, BIRC7
45	doxorubicin32 34 9 9	11.2	KIT, BMP6, BCL2L1, CHEK1, CHEK2, XIAP
46	cisplatin32 34 9 9	10.2	PCNA, RB1, SERPINB5, VEGFA, MYC, BMP6
47	methotrexate32 34 42 9 9	11.2	KIT, PCNA, RB1, BMP6, BIRC5, MT2A
48	paclitaxel32 34 9 9	10.1	KIT, PCNA, RB1, VEGFA, MYC, BMP6
49	herbimycin a32 42	8.1	MYC, BMP6, CDK4, CDH1, ITGA6, MMP1
50	dexamethasone32 42 34 9 9	9.8	PCNA, RB1, VEGFA, VEGFC, MYC, BMP6

Cellular components related to esophageal carcinoma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	catenin complex	GO:016342	10.4	CTNNB1, CTNNA1, CDH1, CDH2, JUP
2	cell-cell junction	GO:005911	10.2	SLC2A1, CXADR, DSG1, CTNNB1, CTNNA1, CASK
3	nucleoplasm	GO:005654	10.2	RB1, RBL2, MYC, RARB, ZBTB17, CHEK1
4	cytosol	GO:005829	10.1	KRT14, HDAC1, TYMP, DSG1, DFFA, DFFB
5	basolateral plasma membrane	GO:016323	10.1	PDGFB, EGFR, TGFA, CXADR, SLC2A1, ERBB2
6	proteinaceous extracellular matrix	GO:005578	9.7	MMP3, MMP7, MMP9, SPARC, TGFB1, TFPI2
7	platelet alpha granule lumen	GO:031093	9.5	TGFB1, TIMP1, EGF, PDGFB, SPARC, IGF1
8	external side of plasma membrane	GO:009897	9.5	FASLG, FAS, HLA-DRB1, TNF, IL6ST, ITGA6
9	perinuclear region of cytoplasm	GO:048471	9.4	HSP90B1, ERBB2, CTNNB1, NOS2, EGFR, TGFA
10	cell surface	GO:009986	9.3	FGFR2, TNF, NGFR, PDGFB, ABCB1, ACVR2B
11	extracellular region	GO:005576	8.6	NGFR, COL4A2, NOTCH1, CRP, SPARC, SPINK1
12	cytoplasm	GO:005737	8.5	PTGS2, PTGS1, PTHLH, SP1, SPRR3, SPHK1
13	plasma membrane	GO:005886	7.9	SPHK1, CTNNA1, CTNNB1, NOTCH1, NGFR, PDGFRB
14	nucleus	GO:005634	7.8	PTGS2, PTGS1, PTHLH, SRC, SP1, SPARC
15	extracellular space	GO:005615	7.4	SPARC, PTHLH, TNF, IFNA2, IGF1, FASLG

Biological processes related to esophageal carcinoma according to GeneDecks:

(show top 50)    (show all 71)

id	Name	GO ID	Score	Top Affiliating Genes
1	G1 phase of mitotic cell cycle	GO:000080	11.0	CCND1, RB1, RBL2, CDKN1A, CDKN2B, CDKN1B
2	canonical Wnt receptor signaling pathway	GO:060070	11.0	CTNNB1, PTEN, CCND1, APC, FGF8, FZD7
3	mitotic cell cycle	GO:000278	11.0	CDKN2A, CDK4, CCND1, PLK1, NINL, PSMB8
4	response to DNA damage stimulus	GO:006974	10.8	APC, MAPK3, CCND1, CASP3, TP53, TP73
5	cell-cell signaling	GO:007267	10.7	IL18, FASLG, IFNA2, GJA1, GJB2, PTHLH
6	extracellular matrix disassembly	GO:022617	10.7	TIMP1, MMP9, MMP7, MMP3, MMP2, MMP14
7	collagen catabolic process	GO:030574	10.7	MMP9, MMP7, MMP3, MMP2, MMP13, MMP11
8	cell cycle arrest	GO:007050	10.6	APC, MAP2K1, TP53, TP53INP1, TP73, TGFB1
9	apoptotic DNA fragmentation	GO:006309	10.6	DFFB, DFFA, CASP3, CDKN2A, BAX, BIRC7
10	regulation of apoptotic process	GO:042981	10.5	TP53, TNFRSF10B, DCC, PSMB8, CSTB, NME1
11	heart development	GO:007507	10.4	PDGFB, ACVR2B, TGFBR2, CXADR, EPOR, NOTCH1
12	positive regulation of cell migration	GO:030335	10.2	NOTCH1, PDGFB, PDGFRB, PDPN, EGFR, TGFB1
13	positive regulation of cell division	GO:051781	10.2	APC, CAT, PDGFB, TGFA, TGFB1, FGFR2
14	release of cytochrome c from mitochondria	GO:001836	10.2	SOD2, TP73, TP53, CASP3, BAX, BCL2L1
15	positive regulation of fibroblast proliferation	GO:048146	10.2	BMI1, CDKN1A, CDK4, IGF1, SPHK1, NGFR
16	cell proliferation	GO:008283	10.2	PTEN, SMAD4, PLK1, PDPN, EGFR, TGFA
17	negative regulation of cyclin-dependent protein kinase activity	GO:045736	10.2	PLK1, CASP3, APC, CDKN2A, CDKN1B, CDKN1A
18	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.1	PPARG, TNFRSF10B, TNF, IFI27, FAS, FASLG
19	negative regulation of cell growth	GO:030308	10.1	TGFB1, SMAD4, PPARG, TP53, FGF2, INHBA
20	regulation of stress-activated MAPK cascade	GO:032872	10.1	MAP2K1, MAPK1, MAPK3, MAP2K2, GSTP1
21	fibroblast growth factor receptor signaling pathway	GO:008543	10.1	SRC, PTEN, MAP2K1, MAPK1, MAPK3, MAP2K2
22	positive regulation of mitosis	GO:045840	10.0	TGFA, EGF, PDGFRB, PDGFB, TNF, IGF1
23	virus-host interaction	GO:019048	9.9	SRC, SP1, KRT8, KRT19, TOP1, TGFB1
24	extracellular matrix organization	GO:030198	9.9	TIMP1, COL4A2, TNF, MMP9, MMP7, MMP3
25	negative regulation of transcription, DNA-dependent	GO:045892	9.8	TNF, CTNNB1, PPARG, SMAD4, NOTCH1, PDGFB
26	anti-apoptosis	GO:006916	9.8	TNF, SPHK1, NGFR, TGFA, POLB, HDAC1
27	nerve growth factor receptor signaling pathway	GO:048011	9.7	STAT3, NGFR, SRC, PTEN, CASP3, MAP2K1
28	Ras protein signal transduction	GO:007265	9.7	SRC, TP53, IGF1, MAP2K1, MAPK1, MAPK14
29	cellular response to organic cyclic compound	GO:071407	9.7	TGFB1, PPARG, CTNNB1, TNF, IL18, ITGA6
30	induction of apoptosis	GO:006917	9.6	TP53INP1, TP63, TNF, PTEN, PPARG, TGFB1
31	platelet degranulation	GO:002576	9.6	TF, TGFB1, TIMP1, EGF, PDGFB, SPARC
32	cytokine-mediated signaling pathway	GO:019221	9.5	HLA-B, HLA-DRB1, EGR1, STAT3, STAT5A, STAT5B
33	epidermal growth factor receptor signaling pathway	GO:007173	9.5	SRC, EGF, EGFR, TGFA, TGFB1, ADAM12
34	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	PDGFB, TP53, IGF1, IL6R, IL6, CD44
35	positive regulation of smooth muscle cell proliferation	GO:048661	9.3	IL6R, IGF1, TNF, PTGS2, PDGFB, PDGFRB
36	positive regulation of epithelial cell proliferation	GO:050679	9.3	MYC, BMP6, FGFR2, IGF1, ERBB2, EGFR
37	positive regulation of MAP kinase activity	GO:043406	9.2	TGFB1, VEGFA, MAGED1, ERBB2, TNF, PDGFB
38	response to drug	GO:042493	9.2	GATA3, APC, MMP9, MMP7, CDH1, CDK4
39	signal transduction	GO:007165	9.2	PDGFRB, PPARG, SPHK1, SPARC, SRC, ERBB2
40	positive regulation of transcription, DNA-dependent	GO:045893	9.1	GATA3, TP73, TP63, TP53INP1, TP53, IGF1
41	MAPK cascade	GO:000165	9.1	TGFB1, TGFA, MYC, FGF8, IL18, MAP2K2
42	negative regulation of apoptotic process	GO:043066	9.1	HDAC1, SOD2, DFFA, TIMP1, FGF4, GSTP1
43	blood coagulation	GO:007596	9.0	NOS2, PDGFB, EGF, TIMP1, TGFB1, TF
44	apoptotic process	GO:006915	9.0	EBAG9, PSMB8, DCC, DFFB, DFFA, TGFBR2
45	response to hypoxia	GO:001666	9.0	SMAD4, CRP, NOS2, PDGFB, TGFB1, STAT5B
46	activation of MAPK activity	GO:000187	8.9	MAP2K1, TP73, TNF, TGFA, MAPK1, MAPK14
47	positive regulation of cell proliferation	GO:008284	8.8	HDAC1, TGFBR2, TGFB1, TIMP1, EGFR, FGF8
48	platelet activation	GO:030168	8.6	SPARC, PDGFB, EGF, TIMP1, TGFB1, TF
49	negative regulation of cell proliferation	GO:008285	8.3	DEC1, FGFR2, FGF2, INHBA, ING1, CDKN2A
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.9	IL6, RB1, VEGFA, MYC, FGFR2, FGF4

Molecular functions related to esophageal carcinoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:019901	10.7	APC, CCND1, TP53, TP73, PTEN, PLK1
2	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.5	CASP3, CDKN2A, CDKN1B, CDKN2B, CDKN1A
3	platelet-derived growth factor receptor binding	GO:005161	10.5	VEGFA, FIGF, PDGFB, PDGFRB, TYMP
4	gamma-catenin binding	GO:045295	10.4	DSG1, CTNNA1, APC, CDH1, CDH2
5	protein serine/threonine/tyrosine kinase activity	GO:004712	10.3	ACVR2B, MAP2K1, MAP2K2, AURKB, AURKA, RELN
6	protein phosphatase binding	GO:019903	10.1	EGFR, CTNNB1, ERBB2, HSP90B1, CDH1, CDKN1B
7	enzyme binding	GO:019899	9.8	CTNNB1, CTNNBL1, PPARG, NOTCH1, EGFR, TGFB1
8	identical protein binding	GO:042802	9.8	TP63, TP73, TNF, SMAD4, EGFR, DCC
9	growth factor activity	GO:008083	9.4	IGF1, PDGFB, EGF, TYMP, TGFA, TGFB1
10	protein heterodimerization activity	GO:046982	9.3	FZD9, INHBA, ERBB2, TP53, PDGFB, EGFR
11	protein homodimerization activity	GO:042803	8.9	PTGS2, CAT, IL6ST, IL6R, FGFR2, SP1
12	ATP binding	GO:005524	8.3	PLK1, SPHK1, SRC, TP53, ERBB2, CASK
13	protein binding	GO:005515	6.2	MAGEA4, TNF, TNFRSF10B, PTEN, SRC, SP1