MCID: ESP028
MIFTS: 41

Esophageal Squamous Cell Carcinoma malady

Genetic diseases (common), Cancer diseases categories
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Summaries for Esophageal Squamous Cell Carcinoma

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MalaCards based summary: Esophageal Squamous Cell Carcinoma, also known as squamous cell esophageal cancer, is related to esophagitis and adenocarcinoma. An important gene associated with Esophageal Squamous Cell Carcinoma is LZTS1 (leucine zipper, putative tumor suppressor 1), and among its related pathways is MicroRNAs in cancer. Affiliated tissues include lymph node, endothelial and t cells.

Description from OMIM:46 133239

Aliases & Classifications for Esophageal Squamous Cell Carcinoma

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Sources:
62UMLS, 46OMIM, 44Novoseek
See all sources

Esophageal Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Esophageal Squamous Cell Carcinoma 46
Squamous Cell Esophageal Cancer 44 62
 
Squamous Cell Carcinoma of Esophagus 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases


Related Diseases for Esophageal Squamous Cell Carcinoma

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Graphical network of the top 20 diseases related to Esophageal Squamous Cell Carcinoma:



Diseases related to esophageal squamous cell carcinoma

Symptoms for Esophageal Squamous Cell Carcinoma

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Clinical features from OMIM:

133239

Drugs & Therapeutics for Esophageal Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Esophageal Squamous Cell Carcinoma

Search NIH Clinical Center for Esophageal Squamous Cell Carcinoma

Genetic Tests for Esophageal Squamous Cell Carcinoma

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Anatomical Context for Esophageal Squamous Cell Carcinoma

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MalaCards organs/tissues related to Esophageal Squamous Cell Carcinoma:

32
Lymph node, Endothelial, T cells, Bone, Lung, Pituitary, Neutrophil, Bone marrow, Testis, Myeloid, Spleen, Liver, Monocytes, B cells

Animal Models for Esophageal Squamous Cell Carcinoma or affiliated genes

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Publications for Esophageal Squamous Cell Carcinoma

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Articles related to Esophageal Squamous Cell Carcinoma:

(show top 50)    (show all 1416)
idTitleAuthorsYear
1
Autoantibodies as potential biomarkers for the early detection of esophageal squamous cell carcinoma. (24296751)
2014
2
A meta-analysis of the association between the hOGG1 Ser326Cys polymorphism and the risk of esophageal squamous cell carcinoma. (23762419)
2013
3
Acquired factor V inhibitor developing in a patient with esophageal squamous cell carcinoma. (23080366)
2013
4
Co-expression of AQP3 and AQP5 in esophageal squamous cell carcinoma correlates with aggressive tumor progression and poor prognosis. (23797770)
2013
5
Prognostic significance of p21 expression in patients with esophageal squamous cell carcinoma. (24123000)
2013
6
Mast cells expressing interleukin 17 in the muscularis propria predict a favorable prognosis in esophageal squamous cell carcinoma. (23912243)
2013
7
Dissection of miRNA-miRNA interaction in esophageal squamous cell carcinoma. (24039884)
2013
8
Despite shared susceptibility loci, esophageal squamous cell carcinoma embraces more familial cancer than gastric cardia adenocarcinoma in the Taihang Mountains high-risk region of northern central China. (23286478)
2013
9
Tumor associated macrophage expressing CD204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma. (23648122)
2013
10
Expression and clinical significance of BRCA1 in human esophageal squamous cell carcinoma]. (23336376)
2012
11
Combining proteomics, serum biomarkers and bioinformatics to discriminate between esophageal squamous cell carcinoma and pre-cancerous lesion. (23225851)
2012
12
Reduced nuclear and ectopic cytoplasmic expression of lysyl oxidase-like 2 is associated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma. (22204712)
2012
13
Correlation between gp96 expression and the surgical outcome in patients with esophageal squamous cell carcinoma. (20839070)
2011
14
Expression and clinical significance of the DNA repair enzyme MYH in esophageal squamous cell carcinoma. (22977630)
2011
15
PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary surgery. (21240990)
2011
16
MiRNA profile in esophageal squamous cell carcinoma: downregulation of miR-143 and miR-145. (21218087)
2011
17
Mechanism of loss of human esophageal cancer-related gene 4 (ECRG4) gene expression in esophageal squamous cell carcinoma cell line EC9706]. (22325214)
2011
18
MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells. (21426561)
2011
19
Correlation of hedgehog signal activation with chemoradiotherapy sensitivity and survival in esophageal squamous cell carcinomas. (21127038)
2011
20
Elevated expression of Rad51 is correlated with decreased survival in resectable esophageal squamous cell carcinoma. (21744352)
2011
21
Overexpression of Pim-1 is associated with poor prognosis in patients with esophageal squamous cell carcinoma. (20544717)
2010
22
Expression of NDRG2 in esophageal squamous cell carcinoma. (20331630)
2010
23
Identification of galectin-7 as a potential biomarker for esophageal squamous cell carcinoma by proteomic analysis. (20546628)
2010
24
HOXA13 promotes cancer cell growth and predicts poor survival of patients with esophageal squamous cell carcinoma. (19491265)
2009
25
Suppression of anoikis by SKP2 amplification and overexpression promotes metastasis of esophageal squamous cell carcinoma. (19147533)
2009
26
Identification of aberrant promoter methylation of EDNRB gene in esophageal squamous cell carcinoma. (18564167)
2009
27
TGFB1 and TGFBR2 functional polymorphisms and risk of esophageal squamous cell carcinoma: a case-control analysis in a Chinese population. (17680270)
2008
28
Cortactin overexpression in the esophageal squamous cell carcinoma and its involvement in the carcinogenesis. (19125793)
2008
29
Increase of BIRC5 gene expression in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with expression of genes SMAC/DIABLO and PML encoding its inhibitors]. (18856066)
2008
30
Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma. (18451147)
2008
31
Quantitative detection of TIMP-3 promoter hypermethylation and its prognostic significance in esophageal squamous cell carcinoma. (19020732)
2008
32
Expression of phosphatase of regenerating liver 1 and 3 mRNA in esophageal squamous cell carcinoma. (18684031)
2008
33
Association of the variable number of tandem repeats polymorphism in the promoter region of the SMYD3 gene with risk of esophageal squamous cell carcinoma in relation to tobacco smoking. (18294291)
2008
34
Expression of ezrin and CD44-v6 in human esophageal squamous cell carcinoma and its clinical significance]. (18246799)
2007
35
Tumor-associated macrophages and CD3-zeta expression of tumor-infiltrating lymphocytes in human esophageal squamous-cell carcinoma. (17439593)
2007
36
Risk of p53 gene mutation in esophageal squamous cell carcinoma and habit of betel quid chewing in Taiwanese. (16271069)
2005
37
Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma. (15069682)
2004
38
Methylenetetrahydrofolate reductase C677T polymorphism and predisposition towards esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population. (15449187)
2004
39
Functional STK15 Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal squamous cell carcinoma. (15087379)
2004
40
Protein and gene expression of tumor-associated antigen RCAS1 in esophageal squamous cell carcinoma. (14534714)
2003
41
Clinicopathologic significance of cyclooxygenase-2 overexpression in esophageal squamous cell carcinoma. (12963227)
2003
42
Elevation of preoperative serum C-reactive protein level is related to poor prognosis in esophageal squamous cell carcinoma. (12884238)
2003
43
A new proliferation marker, minichromosome maintenance protein 2, is associated with tumor aggressiveness in esophageal squamous cell carcinoma. (12949987)
2003
44
Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. (12960129)
2003
45
Clinicopathological significance of human macrophage metalloelastase expression in esophageal squamous cell carcinoma. (12417793)
2002
46
Detection of multiple gene hypermethylation in the development of esophageal squamous cell carcinoma. (12376481)
2002
47
A novel gene, NMES1, downregulated in human esophageal squamous cell carcinoma. (12209954)
2002
48
Molecular detection of p16 promoter methylation in the serum of patients with esophageal squamous cell carcinoma. (11595706)
2001
49
Cellular distribution and clinical value of urokinase-type plasminogen activator, its receptor, and plasminogen activator inhibitor-2 in esophageal squamous cell carcinoma. (10666386)
2000
50
Prognostic implication of proliferative markers MIB-1 and PC10 in esophageal squamous cell carcinoma. (8630942)
1996

Variations for Esophageal Squamous Cell Carcinoma

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UniProtKB/Swiss-Prot genetic disease variations for Esophageal Squamous Cell Carcinoma:

64
id Symbol AA change Variation ID SNP ID
1TGFBR2p.Glu526GlnVAR_015816

Clinvar genetic disease variations for Esophageal Squamous Cell Carcinoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1TGFBR2NM_003242.5(TGFBR2): c.1576G> C (p.Glu526Gln)single nucleotide variantPathogenicrs121918714GRCh37Chr 3, 30732963: 30732963

Expression for genes affiliated with Esophageal Squamous Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Esophageal Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophageal Squamous Cell Carcinoma.

Pathways for genes affiliated with Esophageal Squamous Cell Carcinoma

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Pathways related to Esophageal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1MIR99A, MIR25, MIR375, MIR133A1

Compounds for genes affiliated with Esophageal Squamous Cell Carcinoma

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GO Terms for genes affiliated with Esophageal Squamous Cell Carcinoma

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Cellular components related to Esophageal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:00590110.3TGFBR2, PTCH1

Biological processes related to Esophageal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to mechanical stimulusGO:00961210.3TGFBR2, PTCH1
2smoothened signaling pathwayGO:00722410.0TGFBR2, PTCH1

Molecular functions related to Esophageal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen receptor bindingGO:05068110.3RNF6, KDM4C

Products for genes affiliated with Esophageal Squamous Cell Carcinoma

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  • Antibodies
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Sources for Esophageal Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet