MCID: ESP028
MIFTS: 27

Esophageal Squamous Cell Carcinoma malady

Cancer diseases category

Summaries for Esophageal Squamous Cell Carcinoma

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46OMIM, 32MalaCards
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MalaCards: Esophageal Squamous Cell Carcinoma, also known as squamous cell carcinoma of esophagus, is related to squamous cell carcinoma and esophageal cancer. An important gene associated with Esophageal Squamous Cell Carcinoma is LZTS1 (leucine zipper, putative tumor suppressor 1), and among its related pathways are MicroRNAs in cancer and SRF and miRs in Smooth Muscle Differentiation and Proliferation. The compound 5-aza-2deoxycytidine have been mentioned in the context of this disorder. Related mouse phenotype tumorigenesis.

Description from OMIM:46 133239

Aliases & Classifications for Esophageal Squamous Cell Carcinoma

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Sources:
46OMIM, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

esophageal squamous cell carcinoma 46
squamous cell carcinoma of esophagus 60
squamous cell esophageal cancer 44


Related Diseases for Esophageal Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Esophageal Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma32.6KDM4C, TGFBR2, CTAG1B, PTCH1, ALDH2, WWOX
2esophageal cancer31.5TGFBR2, ALDH2, CTAG1B
3adenocarcinoma31.4CTAG1B, PTCH1, ALDH2, WWOX, TGFBR2
4transitional cell carcinoma30.6TGFBR2, PTCH1, CTAG1B
5esophagitis11.8
6gastric squamous cell carcinoma11.0
7gastric adenocarcinoma10.9
8esophageal disease10.6
9gastric cardia carcinoma10.6
10gastric cardia adenocarcinoma10.6
11squamous cell papilloma10.5
12small cell carcinoma10.5
13in situ carcinoma10.5
14lymph node cancer10.5
15papilloma10.5
16bone carcinoma10.5
17lung squamous cell carcinoma10.5
18retinoblastoma10.5
19achalasia10.4
20esophagus squamous cell carcinoma10.4
21atrophic gastritis10.3
22cardia cancer10.3
23cervical squamous cell carcinoma10.3
24cervicitis10.3
25gastritis10.3
26hepatitis10.3
27leukemia10.3
28lung cancer10.3
29lung small cell carcinoma10.3
30non-small cell lung carcinoma10.3
31pancreatitis10.3
32esophageal cancer, somatic10.3
33choriocarcinoma10.3
34iritis10.2
35parathyroid carcinoma10.2
36ataxia telangiectasia10.2
37xeroderma pigmentosum10.2
38eosinophilic esophagitis10.2
39gastric small cell carcinoma10.2
40pemphigus10.2
41barrett's esophagus10.2
42viral esophagitis10.2
43alcoholic gastritis10.2
44duodenitis10.2
45hypercalcemia10.2
46gastroesophageal junction adenocarcinoma10.2
47large cell carcinoma10.2
48acute leukemia10.2
49esophageal lipoma10.2
50anal squamous cell carcinoma10.2

Graphical network of the top 20 diseases related to Esophageal Squamous Cell Carcinoma:



Diseases related to esophageal squamous cell carcinoma

Clinical Features for Esophageal Squamous Cell Carcinoma

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46OMIM
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Clinical features from OMIM:

133239

Drugs & Therapeutics for Esophageal Squamous Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Esophageal Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Esophageal Squamous Cell Carcinoma

Search NIH Clinical Center for Esophageal Squamous Cell Carcinoma

Search CenterWatch for Esophageal Squamous Cell Carcinoma

Genetic Tests for Esophageal Squamous Cell Carcinoma

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Anatomical Context for Esophageal Squamous Cell Carcinoma

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Animal Models for Esophageal Squamous Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Esophageal Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200611.3TGFBR2, ALDH2, PTCH1, WWOX, LZTS1

Publications for Esophageal Squamous Cell Carcinoma

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Genetic Variations for Esophageal Squamous Cell Carcinoma

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Esophageal Squamous Cell Carcinoma:

62
id Symbol AA change Variation ID SNP ID
1TGFBR2p.Glu526GlnVAR_015816

Expression for genes affiliated with Esophageal Squamous Cell Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophageal Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophageal Squamous Cell Carcinoma.

Pathways for genes affiliated with Esophageal Squamous Cell Carcinoma

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Sources:
29KEGG, 37NCBI BioSystems Database
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Pathways related to Esophageal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.1MIR203, MIR133A1, MIR143, MIR145
210.9MIR133A1, MIR143, MIR145
310.9MIR145, MIR143, MIR203

Compounds for genes affiliated with Esophageal Squamous Cell Carcinoma

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44Novoseek
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Compounds related to Esophageal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
15-aza-2deoxycytidine4410.9TGFBR2, BAGE, CTAG1B

GO Terms for genes affiliated with Esophageal Squamous Cell Carcinoma

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Products for genes affiliated with Esophageal Squamous Cell Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophageal Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet