Esophageal Squamous Cell Carcinoma malady

MalaCards: Esophageal Squamous Cell Carcinoma, also known as squamous cell carcinoma of esophagus, is related to esophagitis and carcinoma. An important gene associated with Esophageal Squamous Cell Carcinoma is DEC1 (deleted in esophageal cancer 1), and among its related pathways are Cell Cycle / Checkpoint Control and Molecular Mechanisms of Cancer. The compounds calcium and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, liver and lung, and related mouse phenotypes are growth/size and mortality/aging.

OMIM: 133239

esophageal squamous cell carcinoma 7 33 squamous cell carcinoma of esophagus 43

Diseases related to esophageal squamous cell carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 876)

id	Related Disease	Score	Top Affiliating Genes
1	esophagitis	100.4	ZNF673, ZNF410, ZNF639, PIK3CA, PIN1, PIM1
2	carcinoma	97.7	ZNF673, ZNF410, ZNF639, PIK3CA, PIN1, PIM1
3	adenocarcinoma	71.2	PIK3CA, PIN1, PIM1, NCAM1, NCOA3, RECK
4	gastric cancer	62.5	PIK3CA, PIN1, PIM1, LRP1B, NCOA3, RECK
5	leukemia	59.4	ZNF673, PIK3CA, PIN1, PIM1, NCAM1, NCOA3
6	hypoxia	49.8	PIK3CA, PIM1, RECK, RELA, KIT, PCNA
7	lung carcinoma	49.7	PIK3CA, LRP1B, NCAM1, RECK, PCNA, RB1
8	squamous cell carcinoma	47.1	RBP1, SERPINB3, PAK1, LGALS3, CD44, CDH1
9	esophageal cancer	46.5	PIK3CA, PCNA, RB1, SERPINB3, BRCA2, VHL
10	retinoblastoma	39.2	PIK3CA, NCAM1, RECK, KIT, PCNA, RB1
11	gastric adenocarcinoma	36.4	PIK3CA, VEGFC, MYC, BIRC5, CLDN4, CLDN7
12	polyposis	36.1	PIN1, RELA, PCNA, RB1, SELE, SERPINE1
13	non-small cell lung carcinoma	35.9	NCAM1, PCNA, RB1, SETD2, VEGFA, VEGFC
14	prostatitis	35.4	ZNF673, PIK3CA, PIN1, PIM1, LRP1B, NCAM1
15	adenomatous polyposis coli	35.0	LMNA, MYC, BMP6, BIRC5, CLU, BCL2
16	gastric cardia adenocarcinoma	34.6	MYC, RASSF1, MTHFR, S100A8, MMP12, MMP13
17	pancreatitis	34.2	PIK3CA, PIN1, PIM1, NCAM1, NCOA3, RECK
18	xeroderma pigmentosum	33.8	PCNA, LMNA, PARP1, BCL2, BAX, XRCC1
19	pituitary tumor	33.2	NCAM1, RB1, PBX1, LGALS3, CHGA, CDKN1B
20	t-cell leukemia	33.1	RELA, MYC, BIRC5, BCL2, LGALS3, LBX1
21	duodenitis	33.0	KIT, PCNA, RARB, BCL2, LGALS3, CHGA
22	gastritis	32.3	S100A8, CDX2, MLH1, MGMT, GSTT1, IL8
23	atrophic gastritis	31.5	PCNA, CHGA, MUC1, MTHFR, S100A8, CEACAM3
24	hypercalcemia	30.7	BMP6, CHGA, CD36, FGF2, IL6, CCND1
25	hepatocellular carcinoma	30.7	PIK3CA, PIN1, NCAM1, NCOA3, RECK, RELA
26	hepatitis	30.1	PIK3CA, PIN1, PIM1, NCAM1, NCOA3, RELA
27	melanoma	29.5	PIK3CA, PIM1, NCAM1, NCOA3, RECK, RELA
28	cervicitis	28.5	PIK3CA, PIN1, RECK, RELA, KIT, SFN
29	breast carcinoma	28.0	PIK3CA, NCOA3, RECK, KIT, KISS1, KISS1R
30	thyroiditis	27.9	PIK3CA, PIN1, LRP1B, NCAM1, NCOA3, RECK
31	colon cancer	27.4	PIK3CA, NCAM1, RECK, RELA, SFN, PCNA
32	neuronitis	27.3	PIK3CA, PIN1, PIM1, NCAM1, RECK, RELA
33	neuroblastoma	24.5	PIK3CA, PIN1, NCAM1, RECK, RELA, RERE
34	cervical cancer	23.6	PIK3CA, PIN1, RELA, SFN, PCNA, RB1
35	ovarian carcinoma	23.6	PIK3CA, NCOA3, RECK, RELA, KIT, KISS1
36	adenoma	23.4	ZNF410, PIK3CA, NCAM1, NCOA3, RECK, KIT
37	oral squamous cell carcinoma	23.1	PIK3CA, PIN1, PIM1, LRP1B, RECK, SFN
38	sarcoma	22.1	PIK3CA, NCAM1, NCOA3, RECK, RELA, KIT
39	gonococcal synovitis	21.7	PIK3CA, NCAM1, RECK, RELA, RBP4, SELE
40	nasopharyngitis	21.5	PIK3CA, NCOA3, RECK, RELA, KIT, SFN
41	myeloid leukemia	20.7	ZNF673, PIK3CA, PIN1, PIM1, NCAM1, NCOA3
42	laryngitis	20.7	PIK3CA, PIM1, RELA, SFN, PCNA, PCDH17
43	bartter disease	20.3	PIK3CA, NCOA3, PCNA, RB1, RBP1, SERPINB3
44	fibrosis	20.3	PIK3CA, PIN1, NCOA3, RECK, RELA, KIT
45	cholangiocarcinoma	20.3	PIK3CA, NCAM1, RECK, KIT, SFN, PCNA
46	boomerang dysplasia	20.2	PIK3CA, PCNA, RB1, VHL, LMNA, MYC
47	arthritis	20.2	PIN1, RECK, RELA, KIT, VTCN1, PCNA
48	endometrial carcinoma	20.0	PIK3CA, NCOA3, RELA, KIT, KISS1, KISS1R
49	colon carcinoma	19.6	PIK3CA, NCAM1, KIT, SELE, SETD2, SERPINB2
50	astrocytoma	19.6	PIK3CA, NCAM1, RECK, RELA, KIT, PCNA

Clinical features from OMIM: 133239

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to esophageal squamous cell carcinoma:

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MGI Mouse Phenotypes related to esophageal squamous cell carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	24.4	PIK3CA, PIN1, PIM1, NCOA3, RECK, RELA
2	mortality/aging	MP:0010768	24.1	PIK3CA, NCAM1, RECK, RELA, RERE, KISS1
3	cellular phenotype	MP:0005384	23.4	PIK3CA, PIN1, PIM1, NCAM1, NCOA3, RELA
4	homeostasis/metabolism phenotype	MP:0005376	22.7	PIK3CA, NCOA3, RELA, KIT, KISS1, KISS1R
5	nervous system phenotype	MP:0003631	19.4	RECK, RELA, RERE, KIT, KISS1, KISS1R
6	integument phenotype	MP:0010771	18.9	PIN1, NCOA3, RECK, RELA, KIT, KISS1
7	immune system phenotype	MP:0005387	18.8	NCOA3, KIT, KISS1R, VTCN1, SFN, PCTP
8	hematopoietic system phenotype	MP:0005397	18.5	PIM1, KIT, KISS1R, VTCN1, SFN, PCNA
9	embryogenesis phenotype	MP:0005380	18.2	PIK3CA, NCOA3, RECK, RERE, KIT, KIF22
10	cardiovascular system phenotype	MP:0005385	17.6	PIK3CA, RECK, RELA, RERE, KIT, RB1
11	digestive/alimentary phenotype	MP:0005381	17.1	NCOA3, KIT, KISS1, KISS1R, SFN, RB1
12	behavior/neurological phenotype	MP:0005386	17.0	PIK3CA, NCAM1, NCOA3, KIT, KISS1R, RB1
13	tumorigenesis	MP:0002006	16.7	PIK3CA, NCOA3, KIT, SFN, RB1, SERPINE1
14	reproductive system phenotype	MP:0005389	16.3	PIK3CA, NCOA3, KISS1, KISS1R, SFN, RBP4
15	normal phenotype	MP:0002873	16.2	LRP1B, RELA, RERE, KISS1R, VTCN1, PCTP
16	skeleton phenotype	MP:0005390	15.8	RECK, RELA, KIT, SFN, RB1, BRCA2
17	renal/urinary system phenotype	MP:0005367	15.5	NCOA3, KIT, KISS1, KISS1R, VHL, LMNA
18	vision/eye phenotype	MP:0005391	15.3	PIK3CA, PIN1, NCAM1, RELA, RERE, KIT
19	muscle phenotype	MP:0005369	14.3	PIK3CA, NCOA3, RELA, KIT, RB1, RBP4
20	limbs/digits/tail phenotype	MP:0005371	14.3	RECK, RELA, KIT, SFN, RB1, BRCA2
21	endocrine/exocrine gland phenotype	MP:0005379	14.0	KISS1, KISS1R, SFN, BRCA2, XPA, ATF3
22	craniofacial phenotype	MP:0005382	13.6	NCOA3, RERE, KIT, BMI1, LIG3, PBX1
23	liver/biliary system phenotype	MP:0005370	12.8	NCOA3, RECK, KIT, SFN, PCTP, RBP1
24	pigmentation phenotype	MP:0001186	12.6	KIT, RB1, RBP1, LMNA, MYC, RAB27A
25	no phenotypic analysis	MP:0003012	12.2	KIF22, PCNA, RB1, SEMA5B, VEGFA, MYC
26	hearing/vestibular/ear phenotype	MP:0005377	11.9	NCOA3, KIT, SFN, RB1, RBP1, LMNA
27	other phenotype	MP:0005395	11.7	RECK, SERPINH1, RARB, CLU, PBX1, KDR
28	adipose tissue phenotype	MP:0005375	11.5	PIK3CA, NCOA3, RB1, SERPINE1, LMNA, MYC
29	respiratory system phenotype	MP:0005388	10.8	TP63

Articles related to esophageal squamous cell carcinoma:

(show top 50)    (show all 727)

id	Title	Authors	Year	Affiliating Genes
1	Association of matrix metalloproteinase-7 (-181A>G ) polymorphism with risk of esophageal squamous cell carcinoma in Kashmir Valle y. (21912055)	Malik M.A.... Mittal B.	2011	MMP7
2	High expression of Y-box-binding protein-1 is associa ted with poor survival in resectable esophageal squamous cell carcinoma. (21630125)	Li Y.... Jia W.H.	2011	YBX1
3	Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patien ts of Kashmir valley. (21385099)	Hussain S.... Das B.C.	2011	SOCS1
4	Correlation of hedgehog signal activation with chemor adiotherapy sensitivity and survival in esophageal squamous cell carcinomas. (21127038)	Zhu W.... Chen X.	2011	GLI1, PTCH1
5	Diet folate, DNA methylation and genetic polymorphism s of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma. (21375764)	Lu C.... Wang J.	2011	MLH1, CDKN2A, MGMT
6	Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells. (21249313)	Xie J.J.... Li E.M.	2011	CYR61
7	Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley: a high risk area. (21268129)	Hussain S.... Bharadwaj M.	2011	CCND1
8	The relationship between RACK1 expression and clinic opathologic information of esophageal squamous cell carcinoma]. (21756811)	Wang Z.Y.... Dai G.H.	2011	GNB2L1
9	Expression and prognostic relevance of Id1 in stage I II esophageal squamous cell carcinoma. (21896993)	Liu J.... Fu J.	2010-2011	ID1
10	Increased expression of prohibitin and its relationsh ip with poor prognosis in esophageal squamous cell carcinoma. (20069396)	Ren H.Z.... Shan X.Z.	2010	PHB
11	The onset of angiogenesis in a multistep process of esophageal squamous cell carcinoma. (19273317)	Kubota Y.... Imawari M.	2009	ENG
12	Chloroform extract of cigarette smoke induces prolife ration of human esophageal squamous-cell carcinoma cells: modulation by beta-ad renoceptors. (19538012)	Li P.... Cho C.H.	2009	PTGS2, ADRB2, ADRB1
13	Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma. (18451147)	Ito T.... Sato F.	2008	PTTG1
14	Germline BRCA2 mutations and the risk of esophageal squamous cell carcinoma. (17724471)	Akbari M.R.... Narod S.A.	2008	BRCA2
15	P53 gene codon 72 polymorphism and risk of esophageal squamous cell carcinoma: a case/control study in a Chinese population. (18269649)	Shao Y.... Zhang S.	2008	TP53
16	Esophageal squamous cell carcinomas and expression of p53, Bcl-2, and Bcl-X(L). (18998283)	Vlachos K.... Hakim N.	2008	BCL2
17	Overexpression of cyclooxygenase-2 is associated with chemoradiotherapy resistance and prognosis in esophageal squamous cell carcinoma patients. (18459994)	Huang W.Z.... Rong T.H.	2008	PTGS2
18	Correlation of aberrant methylation of MGMT gene to MTHFR C677T genetic polymorphisms in esophageal squamous cell carcinoma (19079989)	Xue H.C.... Gao J.	2008	MGMT, MTHFR
19	Tumor suppressor Prdx1 is a prognostic factor in esophageal squamous cell carcinoma patients. (17786348)	Hoshino I.... Ochiai T.	2007	PRDX1
20	Chromogranin A-positive tumor cells in human esophageal squamous cell carcinomas. (18158567)	Yuan A.... Cui G.	2007	CHGA
21	Up-regulated manganese superoxide dismutase expression increases apoptosis resistance in human esophageal squamous cell carcinomas. (18167182)	Hu H.... Wang M.R.	2007	SOD2
22	Correlation of 53BP1 and p53 polymorphisms to susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma (17927872)	Cao Y.Y.... Zhang J.H.	2007	TP53, TP53BP1
23	Correlations of XRCC5 polymorphisms to genetic susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in a high incidence region (17355791)	Dong X.J.... Li Y.	2007	XRCC5
24	p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma. (16759795)	Yokoyama A.... Hibi T.	2007	ALDH2, ADH1B
25	The association of XRCC2 gene polymorphism with susceptibility to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma in China (17922422)	Wang N.... Wang S.J.	2007	XRCC2
26	Improvement in radiosensitivity using small interfering RNA targeting p53R2 in esophageal squamous cell carcinoma. (17671702)	Yokomakura N.... Aikou T.	2007	RRM2B
27	Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma. (17094449)	Fukuoka T.... Nakao A.	2006	CDKN2A, CDH13, HLTF
28	Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma. (16639733)	Cai L.... Zhang Z.F.	2006	ALDH2, XRCC1, RERE
29	mRNA expression of RASSF1A in esophageal squamous cell carcinoma and clinical significance thereof (16854302)	Cong D.G.... Zhang T.W.	2006	RASSF1
30	Altered expression of ezrin in esophageal squamous cell carcinoma. (16585385)	Zeng H.... Li E.	2006	EZR
31	Overexpression of Ets-like protein 1 in human esophageal squamous cell carcinoma. (17203534)	Chen A.G.... Liu Z.H.	2006	ELK1
32	A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley. (16810754)	Murtaza I.... Bhat M.L.	2006	TP53
33	PIK3CA and TFRC located in 3q are new prognostic factors in esophageal squamous cell carcinoma. (16788758)	Wada S.... Kawahara K.	2006	PIK3CA, TFRC
34	S100A2 overexpression is frequently observed in esophageal squamous cell carcinoma. (15865073)	Imazawa M.... Nakao A.	2005	S100A2
35	Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway. (16007168)	Wang Y.... Xu N.	2005	MAPRE2, MAPRE1
36	Expression of hypoxia-inducible factor-1alpha in esophageal squamous cell carcinoma. (15771621)	Matsuyama T.... Maehara T.	2005	TP53, HIF1A, SETD2
37	Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressed. (15761962)	Yen C.C.... Lin C.H.	2005	TP63
38	Functional STK15 Phe31Ile polymorphism is associated with the occurrence and advanced disease status of esophageal squamous cell carcinoma. (15087379)	Miao X.... Lin D.	2004	AURKA
39	Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. (14647409)	Luo A.... Liu Z.	2004	CTSB, S100A9, KRT4
40	A selective cyclooxygenase-2 inhibitor, NS398, inhibits cell growth and induces cell cycle arrest in the G2/M phase in human esophageal squamous cell carcinoma cells. (15354416)	Kase S.... Ito H.	2004	PTGS2
41	Over-expression of gastrin-releasing peptide in human esophageal squamous cell carcinomas. (14764456)	Fang M.Z.... Yang C.S.	2004	GRP
42	p53 gene codon 72 polymorphism and susceptibility to esophageal squamous cell carcinoma in a Chinese population (11836677)	Zhang L.... Lin D.	2002	TP53
43	Clinical significance and prognostic value of apoptosis related proteins in superficial esophageal squamous cell carcinoma. (11508622)	Matsumoto M.... Aikou T.	2001	TP53, RB1, CDKN1A
44	Assessment of the predictive value of clinical and histopathological factors as well as the immunoexpression of p53 and bcl-2 proteins in response to preoperative chemotherapy for esophageal squamous cell carcinoma. (11206631)	Szumilo J.... D browski A.	2000	TP53, BCL2
45	Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomas. (10820340)	Ohashi K.... Nemori R.	2000	MMP7, MMP1, MMP14
46	Mutation and expression of the metastasis suppressor gene KAI1 in esophageal squamous cell carcinoma. (10964324)	Miyazaki T.... Kuwano H.	2000	CD82
47	Thymidine phosphorylase in human esophageal squamous cell carcinoma. (10023693)	Takebayashi Y.... Aikou T.	1999	TYMP
48	MAD-related genes on 18q21.1, Smad2 and Smad4, are altered infrequently in esophageal squamous cell carcinoma. (9197523)	Maesawa C.... Satodate R.	1997	SMAD2, SMAD4
49	Suppressed apoptotic induction in esophageal squamous cell carcinomas expressing extensive p53 protein. (9001343)	Hamada M.... Tanaka N.	1996	TP53
50	Immunohistologic detection of the epidermal growth factor receptor in human esophageal squamous cell carcinoma. (1702347)	Yano H.... Mori T.	1991	EGFR

Genes related to esophageal squamous cell carcinoma according to GeneCards:

(show top 50)    (show all 584)

id	Symbol	Description	Score	GeneCards Section Context
1	DEC1	deleted in esophageal cancer 1	11.1	Summaries, Publications
2	C15orf48	chromosome 15 open reading frame 48	11.1	Publications, Summaries, Expressions
3	RNF6	ring finger protein (C3H2C3 type) 6	11.1	Publications, Summaries
4	PTCH1	patched 1	11.1	Publications, Summaries
5	KDM4C	lysine (K)-specific demethylase 4C	11.1	Expressions, Summaries
6	ZNF639	zinc finger protein 639	11.1	Publications, Aliases & Descriptions
7	CTAG1B	cancer/testis antigen 1B	11.1	Publications, Aliases & Descriptions
8	GAEC1	gene amplified in esophageal cancer 1	11.0	Publications
9	MIR296	microRNA 296	11.0	Publications
10	MIR133B	microRNA 133b	11.0	Publications
11	MIR133A1	microRNA 133a-1	11.0	Publications
12	MIR10A	microRNA 10a	11.0	Publications
13	MIR205	microRNA 205	11.0	Publications
14	MIR203	microRNA 203	11.0	Publications
15	MIR196A1	microRNA 196a-1	11.0	Publications
16	MIR141	microRNA 141	11.0	Publications
17	MIR27A	microRNA 27a	11.0	Publications
18	MIR143	microRNA 143	11.0	Publications
19	BAGE	B melanoma antigen	11.0	Publications
20	MIR145	microRNA 145	11.0	Publications
21	MYEOV	myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)	11.0	Publications
22	SPRR2A	small proline-rich protein 2A	11.0	Publications
23	MT1G	metallothionein 1G	11.0	Publications
24	S100A14	S100 calcium binding protein A14	11.0	Publications
25	LYPD3	LY6/PLAUR domain containing 3	11.0	Publications
26	SPRR1A	small proline-rich protein 1A	11.0	Publications
27	HOXC6	homeobox C6	11.0	Publications
28	EMP3	epithelial membrane protein 3	11.0	Publications
29	FRAT1	frequently rearranged in advanced T-cell lymphomas	11.0	Publications
30	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0	Publications
31	HOXA13	homeobox A13	11.0	Publications
32	LZTS1	leucine zipper, putative tumor suppressor 1	11.0	Publications
33	C2orf40	chromosome 2 open reading frame 40	11.0	Publications
34	HOXA7	homeobox A7	11.0	Publications
35	FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	11.0	Publications
36	UPK1A	uroplakin 1A	11.0	Publications
37	HOXA5	homeobox A5	11.0	Publications
38	ZNRD1	zinc ribbon domain containing 1	11.0	Publications
39	HOXD9	homeobox D9	11.0	Publications
40	DPH1	DPH1 homolog (S. cerevisiae)	11.0	Publications
41	LGALS7	lectin, galactoside-binding, soluble, 7	11.0	Publications
42	STC2	stanniocalcin 2	11.0	Publications
43	LELP1	late cornified envelope-like proline-rich 1	11.0	Publications
44	HSCB	HscB iron-sulfur cluster co-chaperone homolog (E. coli)	11.0	Publications
45	CDK2AP1	cyclin-dependent kinase 2 associated protein 1	11.0	Publications
46	LBX1	ladybird homeobox 1	11.0	Publications
47	SPRR3	small proline-rich protein 3	11.0	Publications
48	MIR146A	microRNA 146a	11.0	Publications
49	CLDN6	claudin 6	11.0	Publications
50	MINA	MYC induced nuclear antigen	11.0	Publications, Expressions

Pathways related to esophageal squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 221)

id	Pathway	Score	Top Affiliating Genes
1	Cell Cycle / Checkpoint Control3	13.7	PIN1, PCNA, RB1, BRCA2, LMNA, RAD51
2	Molecular Mechanisms of Cancer36	13.0	RB1, VEGFC, MYC, BMP6, RARB, BIRC2
3	Epithelial Adherens Junctions36	12.3	VEGFC, BMP6, PARD3, JUP, CDH2, CDH1
4	Small cell lung cancer20	12.0	PIK3CA, RELA, RB1, MYC, RARB, BIRC2
5	Pancreatic Adenocarcinoma36	11.9	KIT, RB1, BRCA2, VEGFC, BMP6, BIRC5
6	Focal adhesion20	11.6	PIK3CA, VEGFC, BIRC2, PAK1, KDR, BCL2
7	Chronic myeloid leukemia20	11.6	PIK3CA, RELA, RB1, MYC, CDKN1A, CDKN1B
8	PTEN Pathway36	11.5	KIT, VEGFC, KDR, LAMB3, LAMC2, ITGA4
9	Glioblastoma Multiforme36	11.4	RB1, CDKN1A, CDKN1B, CDK4, MGMT, MDM2
10	Bladder cancer20	11.3	RB1, VEGFA, VEGFC, MYC, RASSF1, CDKN1A
11	Colorectal Cancer Metastasis36	11.3	MYC, BIRC5, BAX, MSH2, CDKN1A, CDH1
12	Breast Cancer Regulation by Stathmin136	11.2	PAK1, FIGF, FGF1, FGF10, FGF12, FGF2
13	Melanoma20	11.1	PIK3CA, RB1, CDKN1A, CDKN2A, CDK4, CDH1
14	Endocytosis20	11.1	KIT, PARD3, KDR, FLT1, MET, MDM2
15	ILK Signaling36	11.0	KIT, VEGFC, LIMS1, KDR, LAMB3, LAMC2
16	Prostate cancer20	11.0	PIK3CA, RELA, RB1, BCL2, MTOR, CDKN1A
17	Pancreatic cancer20	10.9	BRCA2
18	Mitochondrial Apoptosis36	10.8	KIT, VEGFC, BMP6, BIRC2, KDR, BCL2
19	Phospholipase-C Pathway36	10.8	KIT, VEGFC, BMP6, KDR, LAMB3, LAMC2
20	Cell adhesion ECM remodeling10	10.7	SERPINE1, SDC2, LAMB3, LAMC2, CD44, ITGB1
21	JNK Pathway36	10.7	KIT, BMP6, PAK1, KDR, BCL2, BAX
22	TGF-beta Signaling Pathways37	10.7	RELA, MYC, MTOR, JUN, FOS, FOXO3
23	Colorectal cancer20	10.7	MSH2, FOS, SMAD2, SMAD3, RHOA, TGFB1
24	Activation of PKC through GPCR36	10.7	KIT, VEGFC, BMP6, KDR, FLT1, FIGF
25	GSK3 Signaling36	10.7	KIT, VEGFC, BMP6, KDR, FRAT1, CDH2
26	Akt Signaling36	10.7	KIT, VEGFC, FIGF, FGF1, FGF10, FGF12
27	14-3-3 Induced Intracellular Signaling36	10.6	VEGFC, JUN, FLT1, FIGF, FGF1, FGF10
28	Cellular Apoptosis Pathway36	10.6	KIT, VEGFC, BMP6, BIRC2, KDR, BCL2
29	Paxillin Interactions36	10.6	KIT, VEGFC, PAK1, KDR, ITGA4, ITGB1
30	MAPK Signaling36	10.5	KIT, VEGFC, MYC, BMP6, PAK1, KDR
31	ERK5 Signaling36	10.5	KIT, VEGFC, MYC, BMP6, KDR, FOS
32	Telomerase Components in Cell Signaling36	10.4	KIT, RB1, VEGFC, MYC, BMP6, KDR
33	Ras Pathway36	10.4	KIT, VEGFC, KDR, JUN, ITGA4, ITGB1
34	Rac1 Pathway36	10.4	BMP6, PAK1, PARD3, KDR, JUN, ITGA4
35	NF-KappaB Family Pathway36	10.4	RELA, VEGFC, BMP6, KDR, FLT1, FIGF
36	DHA Signaling36	10.3	KIT, VEGFC, BMP6, KDR, BCL2, BAX
37	p38 Signaling36	10.3	KIT, VEGFC, BMP6, PAK1, KDR, BCL2
38	NF-KappaB (p50-p65) Pathway36	10.3	RELA, VEGFC, BMP6, KDR, FLT1, FIGF
39	Nuclear Receptor Activation by Vitamin-A36	10.3	NCOA3, KIT, VEGFC, BMP6, RARB, KDR
40	Nanog in Mammalian ESC Pluripotency36	10.2	KIT, VEGFC, BMP6, KDR, FLT1, FIGF
41	TGF-Beta Pathway36	10.2	VEGFC, BMP6, KDR, BCL2, BAX, JUN
42	Apoptotic Pathways in Synovial Fibroblasts36	10.2	KIT, VEGFC, BMP6, KDR, FLT1, FIGF
43	Renin-Angiotensin Pathway36	9.9	KIT, VEGFC, BMP6, PAK1, KDR, JUN
44	MAPK Family Pathway36	9.8	VEGFC, BMP6, PAK1, KDR, BCL2, BAX
45	Rho Family GTPases36	9.8	KIT, VEGFC, BMP6, PAK1, PARD3, KDR
46	PAK Pathway36	9.7	KIT, VEGFC, BMP6, PAK1, KDR, BCL2
47	GPCR Pathway36	9.7	KIT, VEGFC, BMP6, PAK1, KDR, JUN
48	PPAR Pathway36	9.6	KIT, VEGFC, ITGA4, ITGB1, FLT1, FIGF
49	JAK-STAT Pathway36	9.5	KIT, VEGFC, MYC, BMP6, KDR, BCL2
50	Tec Kinases Signaling36	9.2	VEGFC, BMP6, PAK1, BCL2, BAX, ITGA4

Compounds related to esophageal squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 469)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	23.6	PIN1, PIM1, RECK, RELA, KIT, KISS1
2	nitric oxide32 9 18 9	18.9	NCAM1, KIT, RB1, SELE, SERPINH1, SERPINB2
3	paraffin32	15.5	NCAM1, RELA, KIT, PCNA, RB1, RBP1
4	cysteine32	15.4	RECK, PCNA, RBP4, RARB, CLU, PARP1
5	atp32	15.1	PIK3CA, PIM1, NCAM1, RECK, KIT, KIF22
6	thymidine32 18	15.5	PIK3CA, KIT, PCNA, RB1, BRCA2, VEGFC
7	fatty acid32	14.1	RECK, SFN, RBP4, RBP1, CLU, LGALS3
8	cholesterol32 9 18 9	16.8	PIK3CA, RECK, RB1, RBP4, SELE, SERPINE1
9	proline32	13.5	PIN1, PIM1, KISS1R, SETD2, SERPINH1, BSG
10	glucose32	13.3	KIT, KISS1, SETD2, VHL, VEGFC, RAB27A
11	iron32 18	14.1	RECK, RBP4, SETD2, VHL, CDKN2A, CD59
12	polyacrylamide32	12.9	RECK, RB1, RBP4, SERPINH1, BRCA2, RAD51
13	methionine32	12.7	RECK, KIT, SERPINH1, SERPINB2, RASSF1, PARK7
14	arachidonic acid32 9 18 9	15.7	PIK3CA, NCAM1, RECK, KCNK2, MTOR, S100A8
15	aspartate32	12.5	PIN1, PCNA, RBP4, BMP6, UCP1, AURKA
16	arsenite32 18	13.5	PIK3CA, PCNA, SETD2, VEGFA, MYC, LIG3
17	gold32	12.4	RECK, KIT, RBP4, BRCA2, RAD51, CHGA
18	p00332	12.0	KIT, RB1, SERPINE1, BRCA2, RASSF1, CHGA
19	tgf beta132	11.9	SETD2, SERPINE1, BMP6, KDR, CDKN1A, CD36
20	calcitriol32 42 9 18 9	15.9	NCOA3, RB1, MYC, BMP6, RARB, CLU
21	hydroxyurea32 9 9	13.9	KIT, PCNA, BRCA2, MYC, RAD51, CHEK2
22	flavopiridol32 9 9	13.7	KIT, RB1, VEGFA, BIRC5, PARP1, BCL2
23	aspirin32 34 18	13.6	PCNA, SELE, SERPINE1, BMP6, BIRC5, LGALS3
24	tamoxifen32 34 9 9	14.6	PIK3CA, NCOA3, PCNA, SELE, BRCA2, VEGFA
25	nicotine32 34 9 9	14.5	RB1, BIRC5, GRP, ANXA1, CCKBR, CCR7
26	prostaglandin32	11.5	VEGFC, CGB5, CDK4, MMP1, MMP13, MMP3
27	adpribose32	11.5	PIK3CA, PCNA, RB1, BRCA2, LIG3, BIRC5
28	phorbol32	11.5	RBP4, SERPINB2, MYC, CHGA, JUN, CDKN1A
29	okadaic acid32 42	12.4	PIK3CA, RELA, RB1, SERPINB2, MYC, BMP6
30	tetracycline32 9 9	13.4	RB1, S100A8, CDKN2A, CDKN1C, MMP1, MMP13
31	sp 60012532 42	12.4	BIRC2, CDKN1A, MMP1, MMP13, CASP3, TP53
32	phosphatidylserine32 9 9	13.3	RECK, SELE, PARP1, BCL2, MIF, ANXA1
33	doxycycline32 9 9	13.3	CDKN2B, CDKN2A, CDKN1C, MMP1, MMP13, MMP2
34	trastuzumab32 34 9 9	14.1	PIK3CA, KIT, VEGFC, BIRC5, KDR, MUC1
35	depsipeptide32	11.1	RB1, MYC, PAK1, BCL2, BAX, CDKN1A
36	sulindac sulfide32	10.9	PCNA, BMP6, BCL2, BAX, ATF3, JUN
37	4-hydroxytamoxifen32	10.9	NCOA3, BRCA2, MYC, CLU, PARP1, JUN
38	phosphotyrosine32	10.9	PIK3CA, RECK, KIT, KDR, JUP, CDH2
39	dihydrotestosterone32 9 18 9	13.6	NCOA3, SETD2, SERPINE1, BMP6, CLU, CHKA
40	mifepristone32 42 9 9	13.4	BIRC5, MUC1, UCP1, BAX, CGB5, JUN
41	rantes32	10.4	SELE, BMP6, S100A8, JUN, CD44, CD46
42	bortezomib32 9 9	12.4	SETD2, VEGFA, MYC, BIRC5, PARP1, KDR
43	4-hydroxynonenal32 18	11.4	MYC, PARP1, CHKA, BAX, JUN, MMP1
44	thalidomide32 42 9 9	13.4	VEGFA, BIRC2, BIRC5, KDR, CD36, FGF2
45	c2ceramide32	10.3	BECN1, PARP1, BAX, CGB5, JUN, HSPB1
46	taxane32	10.3	VEGFA, BIRC5, KDR, BCL2, MTOR, MTHFR
47	imatinib32 34 9 9	13.2	PIK3CA, KIT, VEGFA, MYC, BMP6, RAD51
48	suramin32 9 9	12.1	NCAM1, RECK, PCNA, VEGFA, BMP6, KDR
49	15-deoxy-delta-12,14-prostaglandin j232	9.6	SERPINE1, VEGFA, MYC, BMP6, BIRC2, BIRC5
50	hydrocortisone32 9 9	11.3	BMP6, PBX1, KDR, MUC1, CD36, MMP1

Cellular components related to esophageal squamous cell carcinoma according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	24.2	ZNF410, ZNF639, PIN1, PIM1, NCOA3, RELA
2	cytosol	GO:005829	16.7	PIK3CA, RELA, KIF22, PCTP, VHL, LIMS1
3	plasma membrane	GO:005886	15.9	PIM1, NCAM1, RECK, KIT, KISS1R, VTCN1
4	nucleoplasm	GO:005654	15.8	PIN1, NCOA3, RELA, PCNA, RB1, BRCA2
5	extracellular region	GO:005576	14.3	NCAM1, KISS1, SERPINB2, SERPINE1, VEGFA, VEGFC
6	nucleolus	GO:005730	13.8	NCOA3, RERE, PCNA, BRCA2, MYC, BMI1
7	perinuclear region of cytoplasm	GO:048471	13.0	SELE, LMNA, RAD51, LIMS1, CLU, BAG1
8	integral to plasma membrane	GO:005887	12.6	CLDN4, CLDN1, CLDN3, KDR, SDC1, SDC2
9	proteinaceous extracellular matrix	GO:005578	12.3	VEGFA, LGALS3, MMP1, MMP10, MMP11, MMP12
10	transcription factor complex	GO:005667	12.0	RELA, CLOCK, PBX2, PARP1, LBX1, JUN
11	extracellular space	GO:005615	12.0	KIT, SFN, RBP4, SELE, SERPINB2, SERPINE1
12	melanosome	GO:042470	11.7	BSG, RAB27A, ITGB1, MMP14, ANXA2, HSPA5
13	midbody	GO:030496	11.7	PIN1, BIRC5, AURKA, AURKB, CENPF, CDK1
14	cell surface	GO:009986	11.6	NCAM1, KISS1R, VEGFA, CD24, CD36, CD59
15	spindle	GO:005819	11.5	KIF22, RB1, MYC, BIRC5, PARD3, MTUS1
16	cell-cell adherens junction	GO:005913	11.1	PARD3, JUP, CDH2, CDH1, APC, CTNNB1
17	membrane raft	GO:045121	10.8	SELE, BSG, CD24, CD36, CD55, ITGB1
18	platelet alpha granule lumen	GO:031093	10.6	SERPINE1, VEGFA, VEGFC, CLU, FIGF, IGF1
19	external side of plasma membrane	GO:009897	10.5	NCAM1, KIT, KDR, CD36, CD44, ITGA4
20	caveola	GO:005901	10.5	SELE, CDH13, FASLG, MAPK1, CAV2, CAV1
21	cytoplasm	GO:005737	INF	PIN1, PIM1, NCOA3, RELA, KIT, KIF22

Biological processes related to esophageal squamous cell carcinoma according to GeneDecks:

(show top 50)    (show all 78)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transcription from RNA polymerase II promoter	GO:000122	14.2	VHL, MYC, BMI1, RARB, PARP1, YBX1
2	mitotic cell cycle	GO:000278	13.5	PCNA, RB1, BIRC5, AURKA, AURKB, CENPF
3	positive regulation of transcription from RNA polymerase II promoter	GO:045944	13.3	NCOA3, RELA, RB1, SERPINE1, VEGFA, MYC
4	apoptotic process	GO:006915	13.1	PIM1, SFN, LMNA, BIRC2, BIRC5, PAK1
5	cell proliferation	GO:008283	12.9	PIM1, SFN, PCNA, XRCC5, CENPF, FSCN1
6	G1/S transition of mitotic cell cycle	GO:000082	12.7	PCNA, RB1, BCL2, LATS2, CDKN1A, CDKN1B
7	negative regulation of transcription, DNA-dependent	GO:045892	12.6	ZNF639, RELA, RB1, LIMS1, BIRC5, YBX1
8	positive regulation of transcription, DNA-dependent	GO:045893	12.3	NCOA3, RELA, RB1, BRCA2, VHL, MYC
9	angiogenesis	GO:001525	12.2	PIK3CA, SETD2, SERPINE1, VEGFA, VEGFC, KDR
10	virus-host interaction	GO:019048	12.1	RELA, RB1, CLDN1, BECN1, KDR, BAX
11	positive regulation of apoptotic process	GO:043065	12.0	RARB, CLU, BAX, ITGB1, MMP9, APC
12	cell cycle arrest	GO:007050	12.0	RB1, MYC, RASSF1, MSH2, KAT2B, CDKN1A
13	transforming growth factor beta receptor signaling pathway	GO:007179	12.0	SERPINE1, MYC, PARP1, PARD3, JUN, CDKN2B
14	cell surface receptor signaling pathway	GO:007166	12.0	BSG, BIRC2, BAG1, CD36, CD59, MIF
15	response to organic cyclic compound	GO:014070	11.9	MSH2, JUN, CDKN1A, CDK1, FGF10, MET
16	keratinocyte differentiation	GO:030216	11.8	SFN, SCEL, LATS2, ANXA1, CASP3, TP63
17	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	11.8	PIN1, MECOM, ENG, HSPA5, TP53, SMAD2
18	negative regulation of apoptotic process	GO:043066	11.8	PIM1, RELA, SERPINE1, VEGFA, MYC, BIRC2
19	response to lipopolysaccharide	GO:032496	11.8	SELE, S100A14, S100A8, S100A9, JUN, MMP9
20	response to drug	GO:042493	11.6	VEGFC, MYC, PARK7, BCL2, MVP, BAG1
21	positive regulation of cell proliferation	GO:008284	11.6	KIT, VEGFA, VEGFC, MYC, BIRC5, KDM4C
22	blood coagulation	GO:007596	11.6	PIK3CA, KIF22, SERPINB2, SERPINE1, BSG, VEGFA
23	transcription initiation from RNA polymerase II promoter	GO:006367	11.6	SERPINE1, MYC, RARB, PARP1, KAT2B, CDKN2B
24	signal transduction	GO:007165	11.5	KIT, SFN, VEGFC, RARB, CLOCK, UNC5CL
25	anti-apoptosis	GO:006916	11.5	PIK3CA, RELA, SERPINB2, VHL, BIRC2, BIRC5
26	cellular response to hypoxia	GO:071456	11.5	VHL, VEGFA, LMNA, MTOR, MDM2, ICAM1
27	positive regulation of fibroblast proliferation	GO:048146	11.5	MYC, BMI1, JUN, CDKN1A, CDK4, MIF
28	extracellular matrix organization	GO:030198	11.4	RECK, SERPINH1, LGALS3, MMP1, MMP10, MMP11
29	response to estradiol stimulus	GO:032355	11.3	BRCA2, AURKA, MMP15, MMP9, FOXA1, FGF10
30	wound healing	GO:042060	11.3	PAK1, SDC2, S100A8, FGF10, FGF2, ENG
31	response to hypoxia	GO:001666	11.2	VEGFA, CLDN3, PAK1, BCL2, SDC2, XRCC1
32	response to wounding	GO:009611	11.2	MET, MDK, CASP3, TNC, CTGF, CTSB
33	response to ethanol	GO:045471	11.2	RBP4, BCL2, S100A8, S100A9, CDK1, MMP9
34	positive regulation of cell migration	GO:030335	11.1	VEGFA, KDR, CDH13, ITGB1, MMP14, FLT1
35	release of cytochrome c from mitochondria	GO:001836	11.0	SFN, MYC, CLU, BCL2, BAX, JUN
36	platelet degranulation	GO:002576	11.0	SERPINE1, VEGFA, VEGFC, CLU, CD36, FIGF
37	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	11.0	MYC, BAX, CDKN1B, CDKN2A, FASLG, FADD
38	phosphatidylinositol-mediated signaling	GO:048015	11.0	PIK3CA, PCNA, MTOR, AURKA, CDKN1B, FOXO3
39	negative regulation of cyclin-dependent protein kinase activity	GO:045736	10.9	LATS2, KAT2B, CDKN1A, CDKN1B, CDKN2A, APC
40	inflammatory response	GO:006954	10.8	RELA, KIT, SELE, BMP6, PARK7, S100A8
41	response to estrogen stimulus	GO:043627	10.8	SERPINE1, BCL2, CD24, FAS, CCND1, CAV1
42	positive regulation of protein phosphorylation	GO:001934	10.7	PIN1, VEGFA, MTOR, FGF1, ENG, CCND1
43	induction of apoptosis	GO:006917	10.7	BAX, CDKN1B, CDKN2A, INHBA, FASLG, FAS
44	positive regulation of epithelial cell proliferation	GO:050679	10.5	VEGFC, MYC, BMP6, FGF1, FGF10, GRN
45	positive regulation of MAPK cascade	GO:043410	10.3	KIT, KDR, CD36, CDH2, ITGB1, FLT1
46	positive regulation of protein kinase B signaling cascade	GO:051897	10.3	MTDH, MTOR, CCR7, IGF2, IGF1, HPSE
47	positive regulation of MAP kinase activity	GO:043406	10.1	VEGFA, CD24, FLT1, FGFR1, ERBB2, TNF
48	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.5	NCOA3, KIT, JUP, FOXA1, IL10, IL6
49	positive regulation of smooth muscle cell proliferation	GO:048661	9.4	JUN, CDH13, FLT1, IL6, IGF1, HMOX1
50	negative regulation of cell proliferation	GO:008285	INF	KISS1R, SFN, VHL, RARB, BECN1, LBX1

Molecular functions related to esophageal squamous cell carcinoma according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	26.1	DKK1, POU5F1, PML, RUNX1, RUNX3, NME1
2	sequence-specific DNA binding transcription factor activity	GO:003700	14.8	LBX1, MTA1, ATF3, JUN, CDKN2A, CDX2
3	calcium ion binding	GO:005509	13.6	PLCD1, SULF1, TPM4, HSP90B1, HSPA5, MASP2
4	sequence-specific DNA binding	GO:043565	13.2	EGR1, RXRA, SMAD4, SMAD3, SNAI2, NR2F2
5	transcription factor binding	GO:008134	12.4	KAT2B, TWIST1, TFDP1, TCF7L2, STAT3, PSMD10
6	protein homodimerization activity	GO:042803	12.3	DPP4, DPYD, TAP1, PML, RUNX1, ADRB2
7	protein kinase binding	GO:019901	12.2	SMAD3, PTK2, PTEN, TP73, TP53, HSPB1
8	identical protein binding	GO:042802	11.9	CLDN7, CLDN1, CLDN3, CLDN6, BCL2, BAX
9	ubiquitin protein ligase binding	GO:031625	11.5	SMAD6, SMAD7, NGFR, PDE4D, SKI, HIF1A
10	transcription regulatory region DNA binding	GO:044212	11.5	ZNF639, RELA, XRCC5, JUN, FOS, SMAD4
11	protein heterodimerization activity	GO:046982	11.3	TGFB1, TOP2A, TWIST1, HIF1A, EGFR, TCF4
12	receptor binding	GO:005102	11.2	HLA-G, TNC, TNFSF10, CTNND1, NOS2, LTA
13	cyclin-dependent protein kinase inhibitor activity	GO:004861	11.0	CASP3, CDKN1C, CDKN2A, CDKN1B, CDKN2B, CDKN1A
14	enzyme binding	GO:019899	11.0	RXRA, NOTCH1, PLCE1, PLAUR, PPARG, CTNNB1
15	transmembrane signaling receptor activity	GO:004888	10.9	NGFR, EGFR, AGER, TLR4, THBD, DCC
16	gamma-catenin binding	GO:045295	10.8	DSG1, DSC3, CTNNA1, APC, CDH1, CDH2
17	growth factor activity	GO:008083	10.7	IGF2, IGF1, CTGF, PDGFA, EGF, HBEGF
18	double-stranded DNA binding	GO:003690	10.6	SMAD3, CREB1, RXRA, NFKB1, EGFR, EGR1
19	beta-catenin binding	GO:008013	10.6	CTNNBIP1, SMAD3, SMAD7, TCF7L2, EP300, CTNNA1
20	cytokine activity	GO:005125	10.1	TNF, TNFSF10, SPP1, LTA, EDN1, WNT1