MCID: ESP028
MIFTS: 39

Esophageal Squamous Cell Carcinoma malady

Cancer category

Summaries for Esophageal Squamous Cell Carcinoma

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47OMIM, 33MalaCards
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MalaCards: Esophageal Squamous Cell Carcinoma, also known as squamous cell carcinoma of esophagus, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Esophageal Squamous Cell Carcinoma is LZTS1 (leucine zipper, putative tumor suppressor 1), and among its related pathways are MicroRNAs in cancer and SRF and miRs in Smooth Muscle Differentiation and Proliferation. Affiliated tissues include liver, lymph node and lung.

Description from OMIM:47 133239

Aliases & Classifications for Esophageal Squamous Cell Carcinoma

Sources:
61UMLS, 47OMIM, 45Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

esophageal squamous cell carcinoma 47
squamous cell carcinoma of esophagus 61
squamous cell esophageal cancer 45


Related Diseases for Esophageal Squamous Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Esophageal Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma32.7WWOX, CTAG1B, BAGE, KDM4C, PTCH1, ALDH2
2adenocarcinoma31.4WWOX, CTAG1B, PTCH1, ALDH2
3anal squamous cell carcinoma11.1
4gastric squamous cell carcinoma11.0
5gastric cardia adenocarcinoma10.9
6squamous cell papilloma10.8
7hypoxia10.8
8small cell carcinoma10.6
9bone carcinoma10.5
10achalasia10.5
11atrophic gastritis10.4
12cardia cancer10.4
13esophageal cancer, somatic10.4
14paraneoplastic syndromes10.2
15iritis10.2
16parathyroid carcinoma10.2
17ataxia telangiectasia10.2
18xeroderma pigmentosum10.2
19acute t cell leukemia10.2
20eosinophilic esophagitis10.2
21gastric small cell carcinoma10.2
22pemphigus10.2
23barrett's esophagus10.2
24alcoholic gastritis10.2
25hypercalcemia10.2
26gastroesophageal junction adenocarcinoma10.2
27large cell carcinoma10.2
28acute leukemia10.2
29esophageal lipoma10.2
30adenoma10.2
31t cell deficiency10.2
32t-cell leukemia10.2
33apo a-i deficiency10.2
34tracheoesophageal fistula10.2
35oral squamous cell carcinoma10.2
36ataxia10.2
37syncope10.2
38xeroderma pigmentosum, group c10.2
39lung cancer susceptibility 510.2
40lung cancer susceptibility10.2
41xeroderma pigmentosum, group g10.2
42paraneoplastic pemphigus10.2
43invasive mole10.2
44stomach cancer10.0ALDH2, CTAG1B, PTCH1
45hepatocellular carcinoma10.0PTCH1, BAGE, CTAG1B, ALDH2
46esophageal cancer10.0ALDH2
47melanoma10.0PTCH1, BAGE, CTAG1B
48colorectal cancer10.0ALDH2
49prostate cancer10.0CTAG1B
50colon cancer10.0PTCH1

Graphical network of the top 20 diseases related to Esophageal Squamous Cell Carcinoma:



Diseases related to esophageal squamous cell carcinoma

Clinical Features for Esophageal Squamous Cell Carcinoma

Sources:
47OMIM
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Clinical features from OMIM:

133239

Drugs & Therapeutics for Esophageal Squamous Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Esophageal Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Esophageal Squamous Cell Carcinoma

Search NIH Clinical Center for Esophageal Squamous Cell Carcinoma

Search CenterWatch for Esophageal Squamous Cell Carcinoma

Genetic Tests for Esophageal Squamous Cell Carcinoma

Anatomical Context for Esophageal Squamous Cell Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Esophageal Squamous Cell Carcinoma:

33
Liver, Lymph node, Lung, Spleen, Bone marrow, Whole blood, Testis, Myeloid, Monocytes, T cells, B cells, Endothelial, Pituitary

Animal Models for Esophageal Squamous Cell Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Esophageal Squamous Cell Carcinoma

Sources:
51PubMed
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Articles related to Esophageal Squamous Cell Carcinoma:

(show top 50)    (show all 1464)
idTitleAuthorsYear
1
LINE-1 Hypomethylation, DNA Copy Number Alterations, and CDK6 Amplification in Esophageal Squamous Cell Carcinoma. (24423610)
2014
2
Early-stage esophageal squamous cell carcinoma treated with californium-252 neutron brachytherapy: clinical report on 16 cases. (23748810)
2013
3
S-1 monotherapy as second- or third-line chemotherapy for unresectable and recurrent esophageal squamous cell carcinoma. (23595163)
2013
4
Overexpression of Cdc25C predicts response to radiotherapy and survival in esophageal squamous cell carcinoma patients treated with radiotherapy followed by surgery. (23470146)
2013
5
Sex differences in the proportion of esophageal squamous cell carcinoma cases attributable to tobacco smoking and alcohol consumption. (23830137)
2013
6
Slug is a predictor of poor prognosis in esophageal squamous cell carcinoma patients. (24367561)
2013
7
Endoscopic ultrasound combined with submucosal saline injection for differentiation of T1a and T1b esophageal squamous cell carcinoma: a novel technique. (23807801)
2013
8
Association of PYGO2 and EGFR in esophageal squamous cell carcinoma. (23456637)
2013
9
The overexpression of DBC1 in esophageal squamous cell carcinoma correlates with poor prognosis. (22127596)
2012
10
Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma. (22844531)
2012
11
S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells. (22408350)
2012
12
Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): a case-control study in eastern Chinese populations. (22203178)
2012
13
Human papillomavirus type 16 infection may be involved in esophageal squamous cell carcinoma carcinogenesis in Chinese Kazakh patients. (23607265)
2012
14
CCN1 Induces I^-Catenin Translocation in Esophageal Squamous Cell Carcinoma through Integrin I+11. (22701179)
2012
15
S100A4 mediated cell invasion and metastasis of esophageal squamous cell carcinoma via the regulation of MMP-2 and E-cadherin activity. (21603862)
2012
16
DNA methylation status of RARI^2 and p16(INK4I+) in peripheral blood and tumor tissue in patients with esophageal squamous cell carcinoma]. (22967446)
2012
17
MiRNA profile in esophageal squamous cell carcinoma: downregulation of miR-143 and miR-145. (21218087)
2011
18
Deleted in Esophageal Cancer 1(DEC1) is down-regulated and contributes to migration in head and neck squamous cell carcinoma cell lines. (20975315)
2011
19
STC2: a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma. (20734150)
2011
20
The ECRG1 290Arg/Gln polymorphism is related to risk of esophageal squamous cell carcinoma in Kashmir. (21517269)
2011
21
Epigenetic inactivation of the SFRP1 gene in esophageal squamous cell carcinoma. (21567192)
2011
22
Clinical significance of abnormal expression of Aurora-A in human esophageal squamous cell carcinoma with or without lymph node metastasis]. (21163064)
2010
23
Expression and significance of tumor drug resistance related proteins and beta-catenin in esophageal squamous cell carcinoma. (20193114)
2010
24
Steroid and xenobiotic receptor in human esophageal squamous cell carcinoma: a potent prognostic factor. (19860844)
2010
25
Significance of Jab1 expression in human esophageal squamous cell carcinoma. (19349901)
2009
26
XRCC1 gene polymorphisms and esophageal squamous cell carcinoma risk in Chinese population: A meta-analysis of case-control studies. (19444915)
2009
27
Iritis and iris neoplasm as the presenting signs of esophageal squamous cell carcinoma. (19606176)
2009
28
Correlation between HLA-DRB1*0901 and 1501, HLA-DQB1*0301 and 0602 alleles and esophageal squamous cell carcinoma of Kazakh in Xinjiang, China]. (20193456)
2009
29
Quantitative detection of TIMP-3 promoter hypermethylation and its prognostic significance in esophageal squamous cell carcinoma. (19020732)
2008
30
Correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma. (18499069)
2008
31
Proteomics-based identification of autoantibody against CDC25B as a novel serum marker in esophageal squamous cell carcinoma. (18722351)
2008
32
Esophageal squamous cell carcinomas and expression of p53, Bcl-2, and Bcl-X(L). (18998283)
2008
33
Esophageal granular cell tumor covered by intramucosal squamous cell carcinoma: report of a case. (18612793)
2008
34
Expression and clinical significance of hypoxia inducible factor-1alpha, survivin and vascular endothelial growth factor in esophageal squamous cell carcinoma]. (18194604)
2007
35
Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma. (17318615)
2007
36
Inhibitory effects of Gleditsia sinensis fruit extract on telomerase activity and oncogenic expression in human esophageal squamous cell carcinoma. (17487429)
2007
37
pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus. (17461478)
2007
38
SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. (16458427)
2007
39
Co-expression of aFGF and FGFR-1 is predictive of a poor prognosis in patients with esophageal squamous cell carcinoma. (17273733)
2007
40
Dietary selenium intake and genetic polymorphisms of the GSTP1 and p53 genes on the risk of esophageal squamous cell carcinoma. (16492918)
2006
41
Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas. (16144920)
2005
42
Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. (15205355)
2004
43
Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China. (14669306)
2003
44
Cell culture in esophageal squamous cell carcinoma and the association with molecular markers. (12538476)
2003
45
Relationship between the expression of adhesion molecules in primary esophageal squamous cell carcinoma and metastatic lymph nodes. (14666731)
2003
46
Clinicopathological significance of human macrophage metalloelastase expression in esophageal squamous cell carcinoma. (12417793)
2002
47
Prognostic value of TP53 transcriptional activity on p21 and bax in patients with esophageal squamous cell carcinomas treated by definitive chemoradiotherapy. (12243811)
2002
48
Immunohistochemical characterization of p57KIP2 expression in human esophageal squamous cell carcinoma. (10928132)
2000
49
Clinical significance of dendritic cell infiltration in esophageal squamous cell carcinoma. (9683832)
1998
50
Characterization of p53 gene mutations in esophageal squamous cell carcinoma cell lines: increased frequency and different spectrum of mutations from primary tumors. (8575860)
1996

Genetic Variations for Esophageal Squamous Cell Carcinoma

Expression for genes affiliated with Esophageal Squamous Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Esophageal Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophageal Squamous Cell Carcinoma.

Pathways for genes affiliated with Esophageal Squamous Cell Carcinoma

Sources:
30KEGG, 38NCBI BioSystems Database
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Pathways related to Esophageal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.1MIR145, MIR143, MIR133A1, MIR203
210.9MIR143, MIR145, MIR133A1
310.9MIR143, MIR203, MIR145

Compounds for genes affiliated with Esophageal Squamous Cell Carcinoma

GO Terms for genes affiliated with Esophageal Squamous Cell Carcinoma

Sources:
16Gene Ontology
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Molecular functions related to Esophageal Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen receptor bindingGO:05068110.8KDM4C, RNF6

Products for genes affiliated with Esophageal Squamous Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophageal Squamous Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet