MCID: ESP002
MIFTS: 42

Esophageal Varix malady

Rare diseases, Cardiovascular diseases categories
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Summaries for Esophageal Varix

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33MalaCards
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MalaCards: Esophageal Varix, also known as esophageal varices, is related to hypertension and portal hypertension. An important gene associated with Esophageal Varix is SST (somatostatin), and among its related pathways are Selenium Pathway and FOXA2 and FOXA3 transcription factor networks. The compounds amphetamine and gelofusine have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are digestive/alimentary and normal.

Aliases & Classifications for Esophageal Varix

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

esophageal varix 8 10
esophageal varices 8 43 45 62
bleeding esophageal varices 8 45 62
esophageal varices in disease classified elsewhere, with bleeding 8
esophageal varices with bleeding in disease ec 8
esophageal varices without mention of bleeding 8
esophageal varices without bleeding 8
esophageal varices with bleeding 8
bleeding oesophageal varices 8


External Ids:

Disease Ontology8 DOID:112
NCIt40 C78282
ICD9CM27 456.0

Related Diseases for Esophageal Varix

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Esophageal Varix:



Diseases related to esophageal varix

Symptoms for Esophageal Varix

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Drugs & Therapeutics for Esophageal Varix

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Esophageal Varix

Search NIH Clinical Center for Esophageal Varix

Genetic Tests for Esophageal Varix

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Anatomical Context for Esophageal Varix

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33MalaCards
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MalaCards organs/tissues related to Esophageal Varix:

33
Liver

Animal Models for Esophageal Varix or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Esophageal Varix:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5ALB, SST, F2
2MP:00028737.9EVL, ALB, SST, F2
3MP:00053767.7F2, SST, ALB, EVL

Publications for Esophageal Varix

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Sources:
52PubMed
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Articles related to Esophageal Varix:

(show all 28)
idTitleAuthorsYear
1
Stroke after percutaneous transhepatic variceal obliteration of esophageal varix in Caroli syndrome. (24348664)
2013
2
Extended hemangioma from pharynx to esophagus that could be misdiagnosed as an esophageal varix on endoscopy. (24164602)
2013
3
Vascular lesion in an adult mimicking esophageal varix. (23159366)
2013
4
Variceal transection of esophageal varix using the ESD method: new treatment technique for esophageal varix (with video). (22365437)
2012
5
Achalasia cardia with esophageal varix managed with endoscopic ultrasound-guided botulinum toxin injection. (22180005)
2011
6
Hepatic veno-occlusive disease followed by esophageal varix rupture after hematopoietic stem cell transplantation in a 4-year-old boy with stage 4 neuroblastoma. (18176184)
2008
7
Ultrasound system to measure esophageal varix pressure: an in vitro validation study. (15626729)
2005
8
Portal venous flow pattern as a useful tool for predicting esophageal varix bleeding in cirrhotic patients. (15986878)
2005
9
The banding of an esophageal varix. (16151545)
2005
10
Three-dimensional esophageal varix model quantification of variceal volume by high-resolution endoluminal US. (10882970)
2000
11
White ball sign after ligation of the esophageal varix bleeding point. (10625824)
2000
12
Surgery for esophageal varix bleeding in cirrhotic patients during the era of liver transplants. (10500632)
1999
13
Two cases of esophageal varix caused by local hyperdynamic state of gastric arteries. (10430342)
1999
14
Post-inflammatory polyps of esophagus: a rare sequela of endoscopic injection sclerotherapy for esophageal varix. (8293932)
1993
15
Results of experimental endoscopic esophageal varix ligation. (3341642)
1988
16
Solitary esophageal varix simulating a neoplasm. (3248091)
1988
17
Endoscopic esophageal varix ligation: preliminary clinical experience. (3259195)
1988
18
Endoscopic esophageal varix ligation: technique and preliminary results in children. (3266244)
1988
19
Critical evaluation of a pressure-sensitive capsule for measurement of esophageal varix pressure. Studies in vitro and in canine mesenteric vessels. (3557007)
1987
20
Esophageal varix hemorrhage and sclerotherapy--animal studies. (3519190)
1986
21
Idiopathic esophageal varix. (6602526)
1983
22
THORACIC DUCT CANNULATION FOR CONTROL OF ESOPHAGEAL VARIX HEMORRHAGE. A PRELIMINARY REPORT. (14226387)
1965
23
GASTRIC SECRETION IN LIVER DISEASE AND ESOPHAGEAL VARIX RUPTURE. (14052010)
1963
24
PATHOGENESIS OF ESOPHAGEAL VARIX RUPTURE. A STUDY BASED ON GROSS AND MICROSCOPIC EXAMINATION OF THE ESOPHAGUS AT THE TIME OF BLEEDING. (14042680)
1963
25
Pathogenesis of esophageal varix rupture. (13762024)
1961
26
The use of surgical pituitrin in the control of esophageal varix bleeding; an experimental study and report of two cases. (13324606)
1956
27
Severe bleeding of an esophageal varix controlled by oxycel. (18132775)
1949
28
The esophageal varix; a report of 115 cases. (20266943)
1947

Variations for Esophageal Varix

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Expression for genes affiliated with Esophageal Varix

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophageal Varix

Search GEO for disease gene expression data for Esophageal Varix.

Pathways for genes affiliated with Esophageal Varix

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Esophageal Varix according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway38
9.0ALB, F2
29.0ALB, F2

Compounds for genes affiliated with Esophageal Varix

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Esophageal Varix according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1amphetamine45 51 1111.6SST, F2
2gelofusine459.5SST, ALB
35-hydroxytryptamine459.5F2, SST
4dtpa459.5SST, ALB
5captopril45 61 51 29 1113.4ALB, SST
6naloxone45 29 51 1112.4SST, ALB
7cefotetan45 1110.4F2, ALB
8dextran 70459.4ALB, F2
9hepaplastin459.4F2, ALB
10cefoperazone45 1110.4ALB, F2
11acenocoumarol45 51 1111.4ALB, F2
12phenprocoumon45 51 1111.4F2, ALB
13phenylbutazone45 1110.4F2, ALB
14hydroxyethyl starch459.4F2, ALB
15antipyrine45 1110.4ALB, F2
16warfarin45 51 24 1112.3ALB, F2
17kininogen459.3ALB, F2
18thyroxine45 2410.3ALB, SST
19polyethylene glycol459.3F2, ALB
20homocysteine45 2410.3ALB, F2
21epinephrine45 24 1111.2SST, F2
22citrate459.2ALB, F2
23hyaluronic acid45 2410.1ALB, F2
24histamine45 29 2411.1ALB, SST
25calcitriol45 61 24 1112.1ALB, F2
26methotrexate51 45 1111.0F2, ALB
27terlipressin45 119.9ALB, SST, F2
28lactate458.8ALB, SST, F2
29fibrinogen458.7ALB, F2

GO Terms for genes affiliated with Esophageal Varix

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16Gene Ontology
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Cellular components related to Esophageal Varix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.9ALB, F2
2extracellular regionGO:0055768.5ALB, SST, F2
3extracellular spaceGO:0056158.2ALB, SST, F2

Biological processes related to Esophageal Varix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.0ALB, F2
2response to nutrientGO:0075848.8ALB, SST
3cell surface receptor signaling pathwayGO:0071668.7EVL, SST, F2

Products for genes affiliated with Esophageal Varix

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophageal Varix

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet