MCID: ESP002
MIFTS: 41

Esophageal Varix malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Esophageal Varix

Aliases & Descriptions for Esophageal Varix:

Name: Esophageal Varix 12 29 14
Esophageal Varices 12 50 52 14
Bleeding Esophageal Varices 12 52 69
Esophageal Varices in Disease Classified Elsewhere, with Bleeding 12
Esophageal Varices with Bleeding in Disease Ec 12
Esophageal Varices Without Mention of Bleeding 12
Esophageal Varices Without Bleeding 12
Esophageal Varices with Bleeding 12
Bleeding Oesophageal Varices 12

Classifications:



External Ids:

Disease Ontology 12 DOID:112
ICD10 33 I85.01
ICD9CM 35 456.0 456.2 456.20
NCIt 47 C78282

Summaries for Esophageal Varix

MalaCards based summary : Esophageal Varix, also known as esophageal varices, is related to cerebroretinal microangiopathy with calcifications and cysts 2 and budd-chiari syndrome. An important gene associated with Esophageal Varix is SST (Somatostatin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Propranolol and Menthol have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Related Diseases for Esophageal Varix

Diseases related to Esophageal Varix via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
id Related Disease Score Top Affiliating Genes
1 cerebroretinal microangiopathy with calcifications and cysts 2 11.0
2 budd-chiari syndrome 11.0
3 caroli disease 11.0
4 esophagitis 10.5
5 nondystrophic myotonia 10.3 ALB F2
6 trichodysplasia-xeroderma 10.3 ALB SST
7 pharynx carcinoma in situ 10.3 ALB F2
8 secondary syphilis 10.3 ATP4A SST
9 brain edema 10.3 ATP4A SST
10 enamel erosion 10.3 ATP4A SST
11 female infertility of uterine origin 10.3 ALB F2
12 bile duct cystadenocarcinoma 10.3 ALB F2
13 coronary artery dissection, spontaneous 10.3 ALB SST
14 vascular disease 10.3 ALB ATP4A
15 duane retraction syndrome 10.3 ALB F2
16 synostosis 10.3 ATP4A F2
17 small intestinal l-cell glucagon-like peptide producing tumor 10.3 ATP4A F2
18 lethal congenital contracture syndrome 10.3 AFP ALB
19 pleomorphic rhabdomyosarcoma 10.3 ALB ATP4A
20 social phobia 10.3 AFP F2
21 adult botryoid rhabdomyosarcoma 10.3 AFP SST
22 rectum leiomyoma 10.3 AFP F2
23 porencephaly, cerebellar hypoplasia, and internal malformations 10.3 ALB ATP4A
24 chronic gonococcal salpingitis 10.3 ALB ATP4A
25 vascular erectile tumor 10.3 F2 SERPINC1
26 miller-dieker lissencephaly syndrome 10.2 F2 SERPINC1
27 influenza 10.2 F2 SERPINC1
28 pancreatic ductal carcinoma 10.2 F2 SERPINC1
29 mixed epithelial tumor of ovary 10.2 F2 SERPINC1
30 chorioretinal scar 10.2 F2 SERPINC1
31 mixed hepatoblastoma 10.2 F2 SERPINC1
32 peanut allergy 10.2 F2 SERPINC1
33 may-hegglin anomaly 10.2 F2 SERPINC1
34 left-right axis malformations 10.2 F2 SERPINC1
35 lymphocytic colitis 10.2 F2 SERPINC1
36 dmd-related dilated cardiomyopathy 10.2 F2 SERPINC1
37 mucositis 10.2 AFP ATP4A
38 intravascular fasciitis 10.2 ATP4A F2
39 cataract 10.2 ALB SERPINC1
40 kohler's disease 10.2 ALB F2
41 midline cystocele 10.2 F2 SERPINC1
42 klinefelter's syndrome 10.2 AFP ALB
43 schwannoma of jugular foramen 10.2 F2 SERPINC1
44 inhalation anthrax 10.2 ALB ATP4A
45 bullous skin disease 10.2 F2 SERPINC1
46 neuroaxonal dystrophy 10.2 F2 SERPINC1
47 cerebellar astrocytoma 10.2 F2 SERPINC1
48 myopia 10.2 ALB F2
49 periosteal chondrosarcoma 10.2 F2 SERPINC1
50 lynch syndrome 10.2 F2 SERPINC1

Comorbidity relations with Esophageal Varix via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Alcoholic Liver Cirrhosis Deficiency Anemia
Esophageal Disease Esophagitis
Heart Disease Hepatic Encephalopathy
Portal Hypertension

Graphical network of the top 20 diseases related to Esophageal Varix:



Diseases related to Esophageal Varix

Symptoms & Phenotypes for Esophageal Varix

MGI Mouse Phenotypes related to Esophageal Varix:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 ADAM17 ALB ATP4A F2 PKHD1 SST
2 homeostasis/metabolism MP:0005376 9.23 ADAM17 AFP ALB ATP4A EOGT F2

Drugs & Therapeutics for Esophageal Varix

Drugs for Esophageal Varix (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3 525-66-6 4946
2
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
3
Carvedilol Approved, Investigational Phase 4,Phase 3 72956-09-3 2585
4
Isosorbide Dinitrate Approved Phase 4 87-33-2 6883
5
Nadolol Approved Phase 4,Phase 3 42200-33-9 39147
6
Nitric Oxide Approved Phase 4,Phase 3 10102-43-9 145068
7
Prazosin Approved Phase 4 19216-56-9 4893
8
Octreotide Approved, Investigational Phase 4,Phase 1,Phase 2 83150-76-9 383414 6400441
9
Somatostatin Approved Phase 4,Phase 3,Phase 1,Phase 2 38916-34-6, 51110-01-1 53481605
10
Terlipressin Approved, Investigational Phase 4,Phase 3 14636-12-5 72081
11
Ethiodized oil Approved Phase 4,Phase 3 8008-53-5
12
Ethanolamine Oleate Approved Phase 4,Phase 3 2272-11-9 5282489
13
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
14
Pantoprazole Approved Phase 4 102625-70-7 4679
15
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
16
Polidocanol Approved Phase 4 9002-92-0
17
Tranexamic Acid Approved Phase 4 1197-18-8 5526
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
19 Adrenergic Agents Phase 4,Phase 2,Phase 3
20 Adrenergic Antagonists Phase 4,Phase 2,Phase 3
21 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 3
22 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3
23 Antihypertensive Agents Phase 4,Phase 2,Phase 3
24 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
25 Vasodilator Agents Phase 4,Phase 2,Phase 3,Phase 1
26
Proton pump inhibitors Phase 4
27 Adrenergic alpha-1 Receptor Antagonists Phase 4,Phase 3
28 Adrenergic alpha-Antagonists Phase 4,Phase 3
29 Autonomic Agents Phase 4
30 diuretics Phase 4
31 Isosorbide Phase 4
32 isosorbide-5-mononitrate Phase 4
33 Natriuretic Agents Phase 4
34 Nitric Oxide Donors Phase 4
35 Peripheral Nervous System Agents Phase 4,Phase 3
36 Sympatholytics Phase 4
37 Liver Extracts Phase 4,Phase 2,Phase 3,Phase 1
38 Antineoplastic Agents, Hormonal Phase 4,Phase 1,Phase 2
39 Coagulants Phase 4,Phase 3
40 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Hemostatics Phase 4,Phase 3
42 Hormone Antagonists Phase 4
43 Hormones Phase 4
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
45 Lypressin Phase 4
46 Vasoconstrictor Agents Phase 4
47 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
48 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
49 Antibiotics, Antitubercular Phase 4
50 Anti-Infective Agents Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 142)
id Name Status NCT ID Phase
1 Primary Prevention of Patients With Hepatocellular Carcinoma and Concomitant Esophageal Varices Unknown status NCT01970748 Phase 4
2 Endoscopic Band Ligation (EBL) Versus Endoscopic Band Ligation and Propranolol for the Prevention of Variceal Rebleeding in Pts With Previous Variceal Treatment Unknown status NCT00966082 Phase 4
3 Endoscopic Band Ligation (EBL) Versus Endoscopic Band Ligation and Propranolol for the Prevention of Variceal Rebleeding Unknown status NCT00966121 Phase 4
4 Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal Unknown status NCT01059396 Phase 4
5 Endoscopic Treatment Alone Versus Combined Propranolol and Endoscopic Treatment of Acute Variceal Hemorrhage in Patients With Hepatocellular Carcinoma Unknown status NCT01451658 Phase 4
6 Treatment for Prevention of Variceal Rebleeding Guided by the Hemodynamic Response Unknown status NCT00563602 Phase 4
7 Endoscopic Band Ligation (EBL) Versus Propranolol for Primary Prophylaxis of Variceal Bleeding Unknown status NCT00965900 Phase 4
8 RCT of Carvedilol Versus Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage Unknown status NCT01070641 Phase 4
9 Early Feeding Following Ligation of Acute Bleeding Varices Unknown status NCT01287702 Phase 4
10 Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding Unknown status NCT00966355 Phase 4
11 Primary Prevention of Gastric Variceal Bleeding : Endoscopic Treatment Versus Non-selective Beta-blocker Unknown status NCT01298271 Phase 4
12 PROPRANOLOL PLUS LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES? Completed NCT01893541 Phase 4
13 Time Interval for Endoscopic Variceal Ligation Completed NCT01291277 Phase 4
14 A Randomized Controlled Trial Comparing Band Ligation and Cyanoacrylate Injection for Esophageal Varices Completed NCT00799851 Phase 4
15 Hemodynamic Effects of Terlipressin and High Dose Octreotide Completed NCT02119884 Phase 4
16 The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed Completed NCT00534677 Phase 4
17 EVL (Endoscopic Variceal Ligation) Plus Vasoconstrictor vs.Ligation Plus PPI( Proton Pump Inhibitor) in the Control of Acute Esophageal Variceal Bleeding Completed NCT01112852 Phase 4
18 Short Course Terlipressin for Control of Acute Variceal Bleeding Completed NCT00369694 Phase 4
19 A Trial of Ligation Plus Nadolol Versus Nadolol Alone in the Prophylaxis of First Variceal Bleeding in Cirrhosis Completed NCT00921349 Phase 4
20 A Trial of Nadolol Plus Isosorbide Mononitrate Versus Carvedilol for the Prevention of Variceal Rebleeding Completed NCT01103154 Phase 4
21 Band Ligation Versus Transjugular Intrahepatic Portosystemic Stent Shunt (TIPS) in Cirrhotics With Recurrent Variceal Bleeding Non Responding to Medical Therapy Completed NCT00570973 Phase 4
22 Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis for Variceal Bleeding Completed NCT00838864 Phase 4
23 Vasoactive Drugs in Real World Practice Completed NCT02757703 Phase 4
24 Preventing Recurrent Bleeding After Eradication of Esophageal Varices Recruiting NCT02740166 Phase 4
25 Early Precise Diagnosis and Intervention of CPT Based on a Noninvasive 3D-vHPS Recruiting NCT02925975 Phase 4
26 Effect of Entecavir Treatment on Regression and Disease Outcome in HBV-induced Liver Fibrosis and Cirrhosis Patients Recruiting NCT02849132 Phase 4
27 PPI and Esophagogastric Variceal Bleeding in Cirrhotic Patients (PPI: Proton Pump Inhibitors) Recruiting NCT03175731 Phase 4
28 The Effect of Carvedilol VS Endoscopic Therapy in Primary Prophylaxis of High-risk Esophageal Gastric Variceal Bleeding Recruiting NCT02695732 Phase 4
29 Carvedilol as an Adjunct to Endoscopic Cyanoacrylate Injection for Secondary Prophylaxis of Gastric Variceal Bleeding Recruiting NCT02504723 Phase 4
30 The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding Recruiting NCT02385422 Phase 4
31 Effect of PEM Treatment of Superficial Axial and Tributary Vein Reflux on Improvement of Wound Healing in VLUs Recruiting NCT02988063 Phase 4
32 Efficacity and Safety of Tranexamic Acid in Cirrhotic Patients Presenting With Acute Upper Gastrointestinal Bleeding Not yet recruiting NCT03023189 Phase 4
33 Rifaximin and Propranolol Combination Therapy Versus Propranolol Monotherapy in Cirrhotic Patients Unknown status NCT01897051 Phase 2, Phase 3
34 Probiotics for Portal Hypertension Unknown status NCT01134692 Phase 3
35 ABMSC Infusion Through Hepatic Artery in Portal Hypertension Surgery for the Treatment of Liver Cirrhosis Unknown status NCT01560845 Phase 2, Phase 3
36 A Prospective, Randomized Trial of Histoacryl Injection Versus Thrombin in the Control of Acute Gastric Variceal Bleeding Unknown status NCT01717612 Phase 3
37 Efficacy and Safety of Endoscopic Injection of Fibrin Sealant Versus Endoscopic Ligature for Bleeding Esophageal Varices Completed NCT00161915 Phase 3
38 Prevention of Esophageal Varices by Beta-Adrenergic Blockers Completed NCT00006398 Phase 3
39 Danish Carvedilol Study in Portal Hypertension Completed NCT00493480 Phase 3
40 Comparison of Endoscopic Variceal Ligation (EVL) With Propranolol in Non Cirrhotic Portal Hypertension (NCPH) Completed NCT01000779 Phase 3
41 Simvastatin Effect on Portal Hypertension Completed NCT02134626 Phase 3
42 Self-expandable Esophageal Stent Versus Balloon Tamponade in Refractory Esophageal Variceal Bleeding. Completed NCT01242280 Phase 3
43 Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding Completed NCT00331188 Phase 3
44 Comparing Two Methods to Stop Vomiting of Blood Using the Endoscope Completed NCT01131962 Phase 3
45 Efficacy of Statin Association With Standard Treatment in Prevention of Recurrent Hemorrhage in Patient With Cirrhosis and Variceal Bleeding Completed NCT01095185 Phase 3
46 Decompression Intervention of Variceal Rebleeding Trial (DIVERT) Completed NCT00006161 Phase 3
47 Effect of Administration of Rifaximin on the Portal Pressure of Patients With Liver Cirrhosis and Esophageal Varices Recruiting NCT02508623 Phase 3
48 Hepatic Venous Pressure Gradient-guided Versus Standard Beta-blocker Therapy in Primary Prevention of Variceal Bleeding Recruiting NCT01618890 Phase 3
49 Scleroligation for Eradication of Gastroesophageal Varices. Recruiting NCT02646202 Phase 3
50 To Study the Effect of Nonselective Beta Blockers in Advanced Stage Liver Disease With Ascites Recruiting NCT02649335 Phase 3

Search NIH Clinical Center for Esophageal Varix

Genetic Tests for Esophageal Varix

Genetic tests related to Esophageal Varix:

id Genetic test Affiliating Genes
1 Esophageal Varix 29

Anatomical Context for Esophageal Varix

MalaCards organs/tissues related to Esophageal Varix:

39
Liver

Publications for Esophageal Varix

Articles related to Esophageal Varix:

(show all 31)
id Title Authors Year
1
Gastrointestinal: Hepatocellular carcinoma in an esophageal varix. ( 25404106 )
2014
2
Esophageal varix predictive performance of lower esophageal Doppler signals during the swallowing process. ( 24951299 )
2014
3
Emergency treatment of esophageal varix incarceration in the endoscope and ligation device during endoscopic variceal rubber band ligation. ( 25550983 )
2014
4
Extended hemangioma from pharynx to esophagus that could be misdiagnosed as an esophageal varix on endoscopy. ( 24164602 )
2013
5
Vascular lesion in an adult mimicking esophageal varix. ( 23159366 )
2013
6
Stroke after percutaneous transhepatic variceal obliteration of esophageal varix in Caroli syndrome. ( 24348664 )
2013
7
Variceal transection of esophageal varix using the ESD method: new treatment technique for esophageal varix (with video). ( 22365437 )
2012
8
Achalasia cardia with esophageal varix managed with endoscopic ultrasound-guided botulinum toxin injection. ( 22180005 )
2011
9
Hepatic veno-occlusive disease followed by esophageal varix rupture after hematopoietic stem cell transplantation in a 4-year-old boy with stage 4 neuroblastoma. ( 18176184 )
2008
10
Portal venous flow pattern as a useful tool for predicting esophageal varix bleeding in cirrhotic patients. ( 15986878 )
2005
11
The banding of an esophageal varix. ( 16151545 )
2005
12
Ultrasound system to measure esophageal varix pressure: an in vitro validation study. ( 15626729 )
2005
13
Three-dimensional esophageal varix model quantification of variceal volume by high-resolution endoluminal US. ( 10882970 )
2000
14
White ball sign after ligation of the esophageal varix bleeding point. ( 10625824 )
2000
15
Surgery for esophageal varix bleeding in cirrhotic patients during the era of liver transplants. ( 10500632 )
1999
16
Two cases of esophageal varix caused by local hyperdynamic state of gastric arteries. ( 10430342 )
1999
17
Post-inflammatory polyps of esophagus: a rare sequela of endoscopic injection sclerotherapy for esophageal varix. ( 8293932 )
1993
18
Results of experimental endoscopic esophageal varix ligation. ( 3341642 )
1988
19
Solitary esophageal varix simulating a neoplasm. ( 3248091 )
1988
20
Endoscopic esophageal varix ligation: preliminary clinical experience. ( 3259195 )
1988
21
Endoscopic esophageal varix ligation: technique and preliminary results in children. ( 3266244 )
1988
22
Critical evaluation of a pressure-sensitive capsule for measurement of esophageal varix pressure. Studies in vitro and in canine mesenteric vessels. ( 3557007 )
1987
23
Esophageal varix hemorrhage and sclerotherapy--animal studies. ( 3519190 )
1986
24
Idiopathic esophageal varix. ( 6602526 )
1983
25
THORACIC DUCT CANNULATION FOR CONTROL OF ESOPHAGEAL VARIX HEMORRHAGE. A PRELIMINARY REPORT. ( 14226387 )
1965
26
GASTRIC SECRETION IN LIVER DISEASE AND ESOPHAGEAL VARIX RUPTURE. ( 14052010 )
1963
27
PATHOGENESIS OF ESOPHAGEAL VARIX RUPTURE. A STUDY BASED ON GROSS AND MICROSCOPIC EXAMINATION OF THE ESOPHAGUS AT THE TIME OF BLEEDING. ( 14042680 )
1963
28
Pathogenesis of esophageal varix rupture. ( 13762024 )
1961
29
The use of surgical pituitrin in the control of esophageal varix bleeding; an experimental study and report of two cases. ( 13324606 )
1956
30
Severe bleeding of an esophageal varix controlled by oxycel. ( 18132775 )
1949
31
The esophageal varix; a report of 115 cases. ( 20266943 )
1947

Variations for Esophageal Varix

Expression for Esophageal Varix

Search GEO for disease gene expression data for Esophageal Varix.

Pathways for Esophageal Varix

Pathways related to Esophageal Varix according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.44 AFP ALB F2

GO Terms for Esophageal Varix

Cellular components related to Esophageal Varix according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 AFP ALB ATP4A F2 SERPINC1 SST
2 blood microparticle GO:0072562 9.33 ALB F2 SERPINC1
3 endoplasmic reticulum lumen GO:0005788 9.02 AFP ALB EOGT F2 SERPINC1

Biological processes related to Esophageal Varix according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of blood coagulation GO:0030193 8.96 F2 SERPINC1
2 cellular protein metabolic process GO:0044267 8.92 AFP ALB F2 SERPINC1

Sources for Esophageal Varix

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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