MCID: ESP002
MIFTS: 37

Esophageal Varix malady

Summaries for Esophageal Varix

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33MalaCards
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MalaCards: Esophageal Varix, also known as esophageal varices, is related to portal hypertension and alcoholic liver cirrhosis. An important gene associated with Esophageal Varix is TUBGCP4 (tubulin, gamma complex associated protein 4), and among its related pathways is FOXA2 and FOXA3 transcription factor networks. The compounds gelofusine and cefotetan have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are normal and homeostasis/metabolism.

Aliases & Classifications for Esophageal Varix

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM
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Aliases & Descriptions:

esophageal varix 8 10
esophageal varices 8 43 45 61
bleeding esophageal varices 8 45 61
esophageal varices in disease classified elsewhere, with bleeding 8
esophageal varices with bleeding in disease ec 8
esophageal varices without mention of bleeding 8
esophageal varices without bleeding 8
esophageal varices with bleeding 8
bleeding oesophageal varices 8


External Ids:

Disease Ontology8 DOID:112
NCIt40 C78282
ICD9CM27 456.0

Related Diseases for Esophageal Varix

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Esophageal Varix via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1portal hypertension31.0SST, F2, ALB
2alcoholic liver cirrhosis30.5F2, ALB
3hepatitis a30.4F2
4hypersplenism30.3F2, EVL
5hepatitis b30.3AFP, F2, ALB
6portal vein thrombosis30.1F2, AFP
7hepatorenal syndrome30.1ALB, F2
8alcoholic hepatitis30.1F2, ALB
9esophageal atresia10.4
10biliary atresia10.4
11hepatitis c10.3
12hepatitis e10.3
13splenic artery aneurysm10.3
14primary pulmonary hypertension10.2
15primary biliary cirrhosis10.2
16felty's syndrome10.2
17hepatitis d10.2
18down syndrome10.2
19hepatic coma10.2
20superior vena cava syndrome10.2
21somatostatin analog10.2
22achalasia10.1
23hematopoietic stem cell transplantation10.1
24hereditary hemorrhagic telangiectasia10.1
25klippel-trenaunay syndrome10.1
26duodenal ulcer10.1
27adult respiratory distress syndrome10.1
28gastric ulcer10.1
29angiodysplasia10.1
30scimitar syndrome10.1
31polycystic kidney disease10.1
32duodenitis10.1
33adult syndrome10.1
34behcet's disease10.1
35wolman disease10.1
36dieulafoy lesion10.1
37sclerosing cholangitis10.1
38n syndrome10.1
39hepatic vein thrombosis10.1
40constrictive pericarditis10.1
41aortic disease10.1
42phacomatosis pigmentovascularis10.1
43primary sclerosing cholangitis10.1
44fibrosing mediastinitis10.1
45nodular regenerative hyperplasia10.1
46pediatric hypertension10.1
47adams-oliver syndrome 110.1
48image syndrome10.1
49hepatitis c virus10.1
50septic shock10.1

Graphical network of the top 20 diseases related to Esophageal Varix:



Diseases related to esophageal varix

Clinical Features for Esophageal Varix

Drugs & Therapeutics for Esophageal Varix

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Esophageal Varix

Drug clinical trials:

Search ClinicalTrials for Esophageal Varix

Search NIH Clinical Center for Esophageal Varix

Search CenterWatch for Esophageal Varix

Genetic Tests for Esophageal Varix

Anatomical Context for Esophageal Varix

Sources:
33MalaCards
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MalaCards organs/tissues related to Esophageal Varix:

33
Liver

Animal Models for Esophageal Varix or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Esophageal Varix:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.3SST, F2, RAB3D, EVL, ALB
2MP:00053767.3AFP, SST, F2, RAB3D, EVL, ALB

Publications for Esophageal Varix

Sources:
51PubMed
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Articles related to Esophageal Varix:

(show all 28)
idTitleAuthorsYear
1
Stroke after percutaneous transhepatic variceal obliteration of esophageal varix in Caroli syndrome. (24348664)
2013
2
Extended hemangioma from pharynx to esophagus that could be misdiagnosed as an esophageal varix on endoscopy. (24164602)
2013
3
Vascular lesion in an adult mimicking esophageal varix. (23159366)
2013
4
Variceal transection of esophageal varix using the ESD method: new treatment technique for esophageal varix (with video). (22365437)
2012
5
Achalasia cardia with esophageal varix managed with endoscopic ultrasound-guided botulinum toxin injection. (22180005)
2011
6
Hepatic veno-occlusive disease followed by esophageal varix rupture after hematopoietic stem cell transplantation in a 4-year-old boy with stage 4 neuroblastoma. (18176184)
2008
7
Ultrasound system to measure esophageal varix pressure: an in vitro validation study. (15626729)
2005
8
Portal venous flow pattern as a useful tool for predicting esophageal varix bleeding in cirrhotic patients. (15986878)
2005
9
The banding of an esophageal varix. (16151545)
2005
10
Three-dimensional esophageal varix model quantification of variceal volume by high-resolution endoluminal US. (10882970)
2000
11
White ball sign after ligation of the esophageal varix bleeding point. (10625824)
2000
12
Surgery for esophageal varix bleeding in cirrhotic patients during the era of liver transplants. (10500632)
1999
13
Two cases of esophageal varix caused by local hyperdynamic state of gastric arteries. (10430342)
1999
14
Post-inflammatory polyps of esophagus: a rare sequela of endoscopic injection sclerotherapy for esophageal varix. (8293932)
1993
15
Results of experimental endoscopic esophageal varix ligation. (3341642)
1988
16
Solitary esophageal varix simulating a neoplasm. (3248091)
1988
17
Endoscopic esophageal varix ligation: preliminary clinical experience. (3259195)
1988
18
Endoscopic esophageal varix ligation: technique and preliminary results in children. (3266244)
1988
19
Critical evaluation of a pressure-sensitive capsule for measurement of esophageal varix pressure. Studies in vitro and in canine mesenteric vessels. (3557007)
1987
20
Esophageal varix hemorrhage and sclerotherapy--animal studies. (3519190)
1986
21
Idiopathic esophageal varix. (6602526)
1983
22
THORACIC DUCT CANNULATION FOR CONTROL OF ESOPHAGEAL VARIX HEMORRHAGE. A PRELIMINARY REPORT. (14226387)
1965
23
GASTRIC SECRETION IN LIVER DISEASE AND ESOPHAGEAL VARIX RUPTURE. (14052010)
1963
24
PATHOGENESIS OF ESOPHAGEAL VARIX RUPTURE. A STUDY BASED ON GROSS AND MICROSCOPIC EXAMINATION OF THE ESOPHAGUS AT THE TIME OF BLEEDING. (14042680)
1963
25
Pathogenesis of esophageal varix rupture. (13762024)
1961
26
The use of surgical pituitrin in the control of esophageal varix bleeding; an experimental study and report of two cases. (13324606)
1956
27
Severe bleeding of an esophageal varix controlled by oxycel. (18132775)
1949
28
The esophageal varix; a report of 115 cases. (20266943)
1947

Genetic Variations for Esophageal Varix

Expression for genes affiliated with Esophageal Varix

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophageal Varix

Search GEO for disease gene expression data for Esophageal Varix.

Pathways for genes affiliated with Esophageal Varix

Sources:
38NCBI BioSystems Database
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Pathways related to Esophageal Varix according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ALB, F2, AFP

Compounds for genes affiliated with Esophageal Varix

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 24HMDB
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Compounds related to Esophageal Varix according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1gelofusine459.9SST, ALB
2cefotetan45 1110.8F2, ALB
3dextran 70459.8ALB, F2
4hepaplastin459.8ALB, F2
5cefoperazone45 1110.8ALB, F2
6acenocoumarol45 50 1111.8ALB, F2
7phenprocoumon45 50 1111.8F2, ALB
8spec-t459.8SST, AFP
9phenylbutazone45 1110.8F2, ALB
10hydroxyethyl starch459.7F2, ALB
11antipyrine45 1110.7F2, ALB
12dtpa459.7ALB, SST
13amphetamine45 1110.6F2, SST
14captopril45 29 50 60 1113.4SST, ALB
15terlipressin45 1110.4ALB, F2, SST
16polyethylene glycol459.4AFP, F2, ALB
17thyroxine45 2410.4ALB, SST, AFP
18epinephrine45 11 2411.3AFP, SST, F2
19methotrexate45 50 1111.3ALB, F2, AFP
20naloxone45 50 29 1112.2ALB, SST
21fibrinogen459.1ALB, F2, AFP
22lactate459.0AFP, SST, F2, ALB

GO Terms for genes affiliated with Esophageal Varix

Sources:
16Gene Ontology
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Cellular components related to Esophageal Varix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7ALB, F2, SST, AFP

Biological processes related to Esophageal Varix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surface receptor signaling pathwayGO:0071668.8EVL, F2, SST

Products for genes affiliated with Esophageal Varix

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophageal Varix

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet