MCID: ESP002
MIFTS: 42

Esophageal Varix malady

Rare diseases, Cardiovascular diseases categories

Summaries for Esophageal Varix

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34MalaCards
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MalaCards: Esophageal Varix, also known as esophageal varices, is related to hypertension and portal hypertension. An important gene associated with Esophageal Varix is SST (somatostatin), and among its related pathways are Selenium Pathway and FOXA2 and FOXA3 transcription factor networks. The compounds amphetamine and gelofusine have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are digestive/alimentary and normal.

Aliases & Classifications for Esophageal Varix

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

esophageal varix 9 11
esophageal varices 9 44 46 63
bleeding esophageal varices 9 46 63
esophageal varices in disease classified elsewhere, with bleeding 9
esophageal varices with bleeding in disease ec 9
esophageal varices without mention of bleeding 9
esophageal varices without bleeding 9
esophageal varices with bleeding 9
bleeding oesophageal varices 9


External Ids:

Disease Ontology9 DOID:112
NCIt41 C78282
ICD9CM28 456.0

Related Diseases for Esophageal Varix

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Esophageal Varix:



Diseases related to esophageal varix

Symptoms for Esophageal Varix

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Drugs & Therapeutics for Esophageal Varix

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Esophageal Varix

Drug clinical trials:

Search ClinicalTrials for Esophageal Varix

Search NIH Clinical Center for Esophageal Varix

Search CenterWatch for Esophageal Varix

Genetic Tests for Esophageal Varix

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Anatomical Context for Esophageal Varix

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34MalaCards
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MalaCards organs/tissues related to Esophageal Varix:

34
Liver

Animal Models for Esophageal Varix or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Esophageal Varix:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5ALB, SST, F2
2MP:00028737.9EVL, ALB, SST, F2
3MP:00053767.7F2, SST, ALB, EVL

Publications for Esophageal Varix

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Sources:
53PubMed
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Articles related to Esophageal Varix:

(show all 28)
idTitleAuthorsYear
1
Stroke after percutaneous transhepatic variceal obliteration of esophageal varix in Caroli syndrome. (24348664)
2013
2
Extended hemangioma from pharynx to esophagus that could be misdiagnosed as an esophageal varix on endoscopy. (24164602)
2013
3
Vascular lesion in an adult mimicking esophageal varix. (23159366)
2013
4
Variceal transection of esophageal varix using the ESD method: new treatment technique for esophageal varix (with video). (22365437)
2012
5
Achalasia cardia with esophageal varix managed with endoscopic ultrasound-guided botulinum toxin injection. (22180005)
2011
6
Hepatic veno-occlusive disease followed by esophageal varix rupture after hematopoietic stem cell transplantation in a 4-year-old boy with stage 4 neuroblastoma. (18176184)
2008
7
Ultrasound system to measure esophageal varix pressure: an in vitro validation study. (15626729)
2005
8
Portal venous flow pattern as a useful tool for predicting esophageal varix bleeding in cirrhotic patients. (15986878)
2005
9
The banding of an esophageal varix. (16151545)
2005
10
Three-dimensional esophageal varix model quantification of variceal volume by high-resolution endoluminal US. (10882970)
2000
11
White ball sign after ligation of the esophageal varix bleeding point. (10625824)
2000
12
Surgery for esophageal varix bleeding in cirrhotic patients during the era of liver transplants. (10500632)
1999
13
Two cases of esophageal varix caused by local hyperdynamic state of gastric arteries. (10430342)
1999
14
Post-inflammatory polyps of esophagus: a rare sequela of endoscopic injection sclerotherapy for esophageal varix. (8293932)
1993
15
Results of experimental endoscopic esophageal varix ligation. (3341642)
1988
16
Solitary esophageal varix simulating a neoplasm. (3248091)
1988
17
Endoscopic esophageal varix ligation: preliminary clinical experience. (3259195)
1988
18
Endoscopic esophageal varix ligation: technique and preliminary results in children. (3266244)
1988
19
Critical evaluation of a pressure-sensitive capsule for measurement of esophageal varix pressure. Studies in vitro and in canine mesenteric vessels. (3557007)
1987
20
Esophageal varix hemorrhage and sclerotherapy--animal studies. (3519190)
1986
21
Idiopathic esophageal varix. (6602526)
1983
22
THORACIC DUCT CANNULATION FOR CONTROL OF ESOPHAGEAL VARIX HEMORRHAGE. A PRELIMINARY REPORT. (14226387)
1965
23
GASTRIC SECRETION IN LIVER DISEASE AND ESOPHAGEAL VARIX RUPTURE. (14052010)
1963
24
PATHOGENESIS OF ESOPHAGEAL VARIX RUPTURE. A STUDY BASED ON GROSS AND MICROSCOPIC EXAMINATION OF THE ESOPHAGUS AT THE TIME OF BLEEDING. (14042680)
1963
25
Pathogenesis of esophageal varix rupture. (13762024)
1961
26
The use of surgical pituitrin in the control of esophageal varix bleeding; an experimental study and report of two cases. (13324606)
1956
27
Severe bleeding of an esophageal varix controlled by oxycel. (18132775)
1949
28
The esophageal varix; a report of 115 cases. (20266943)
1947

Variations for Esophageal Varix

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Expression for genes affiliated with Esophageal Varix

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophageal Varix

Search GEO for disease gene expression data for Esophageal Varix.

Pathways for genes affiliated with Esophageal Varix

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Sources:
51PathCards, 39NCBI BioSystems Database
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Pathways related to Esophageal Varix according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
thioredoxin pathway39
9.0ALB, F2
29.0ALB, F2

Compounds for genes affiliated with Esophageal Varix

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Esophageal Varix according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1amphetamine46 52 1211.6SST, F2
2gelofusine469.5SST, ALB
35-hydroxytryptamine469.5F2, SST
4dtpa469.5SST, ALB
5captopril46 62 52 30 1213.4ALB, SST
6naloxone46 30 52 1212.4SST, ALB
7cefotetan46 1210.4F2, ALB
8dextran 70469.4ALB, F2
9hepaplastin469.4F2, ALB
10cefoperazone46 1210.4ALB, F2
11acenocoumarol46 52 1211.4ALB, F2
12phenprocoumon46 52 1211.4F2, ALB
13phenylbutazone46 1210.4F2, ALB
14hydroxyethyl starch469.4F2, ALB
15antipyrine46 1210.4ALB, F2
16warfarin46 52 25 1212.3ALB, F2
17kininogen469.3ALB, F2
18thyroxine46 2510.3ALB, SST
19polyethylene glycol469.3F2, ALB
20homocysteine46 2510.3ALB, F2
21epinephrine46 25 1211.2SST, F2
22citrate469.2ALB, F2
23hyaluronic acid46 2510.1ALB, F2
24histamine46 30 2511.1ALB, SST
25calcitriol46 62 25 1212.1ALB, F2
26methotrexate52 46 1211.0F2, ALB
27terlipressin46 129.9ALB, SST, F2
28lactate468.8ALB, SST, F2
29fibrinogen468.7ALB, F2

GO Terms for genes affiliated with Esophageal Varix

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17Gene Ontology
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Cellular components related to Esophageal Varix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.9ALB, F2
2extracellular regionGO:0055768.5ALB, SST, F2
3extracellular spaceGO:0056158.2ALB, SST, F2

Biological processes related to Esophageal Varix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet activationGO:0301689.0ALB, F2
2response to nutrientGO:0075848.8ALB, SST
3cell surface receptor signaling pathwayGO:0071668.7EVL, SST, F2

Products for genes affiliated with Esophageal Varix

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophageal Varix

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet