MCID: ESP002
MIFTS: 37

Esophageal Varix malady

Summaries for Esophageal Varix

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32MalaCards
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MalaCards: Esophageal Varix, also known as esophageal varices, is related to liver cirrhosis and hypertension. An important gene associated with Esophageal Varix is TUBGCP4 (tubulin, gamma complex associated protein 4), and among its related pathways is FOXA2 and FOXA3 transcription factor networks. The compounds gelofusine and cefotetan have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are normal and homeostasis/metabolism.

Aliases & Classifications for Esophageal Varix

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8Disease Ontology, 10DISEASES, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

esophageal varix 8 10
esophageal varices 8 42 44 60
bleeding esophageal varices 8 44 60
esophageal varices in disease classified elsewhere, with bleeding 8
esophageal varices with bleeding in disease ec 8
esophageal varices without mention of bleeding 8
esophageal varices without bleeding 8
esophageal varices with bleeding 8
bleeding oesophageal varices 8


External Ids:

Disease Ontology8 DOID:112
NCIt39 C78282
ICD9CM27 456.0

Related Diseases for Esophageal Varix

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Esophageal Varix:



Diseases related to esophageal varix

Clinical Features for Esophageal Varix

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Drugs & Therapeutics for Esophageal Varix

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Esophageal Varix

Drug clinical trials:

Search ClinicalTrials for Esophageal Varix

Search NIH Clinical Center for Esophageal Varix

Search CenterWatch for Esophageal Varix

Genetic Tests for Esophageal Varix

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Anatomical Context for Esophageal Varix

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32MalaCards
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MalaCards organs/tissues related to Esophageal Varix:

32
Liver

Animal Models for Esophageal Varix or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Esophageal Varix:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028737.3SST, F2, RAB3D, EVL, ALB
2MP:00053767.3AFP, SST, F2, RAB3D, EVL, ALB

Publications for Esophageal Varix

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50PubMed
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Articles related to Esophageal Varix:

(show all 28)
idTitleAuthorsYear
1
Stroke after percutaneous transhepatic variceal obliteration of esophageal varix in Caroli syndrome. (24348664)
2013
2
Extended hemangioma from pharynx to esophagus that could be misdiagnosed as an esophageal varix on endoscopy. (24164602)
2013
3
Vascular lesion in an adult mimicking esophageal varix. (23159366)
2013
4
Variceal transection of esophageal varix using the ESD method: new treatment technique for esophageal varix (with video). (22365437)
2012
5
Achalasia cardia with esophageal varix managed with endoscopic ultrasound-guided botulinum toxin injection. (22180005)
2011
6
Hepatic veno-occlusive disease followed by esophageal varix rupture after hematopoietic stem cell transplantation in a 4-year-old boy with stage 4 neuroblastoma. (18176184)
2008
7
Ultrasound system to measure esophageal varix pressure: an in vitro validation study. (15626729)
2005
8
Portal venous flow pattern as a useful tool for predicting esophageal varix bleeding in cirrhotic patients. (15986878)
2005
9
The banding of an esophageal varix. (16151545)
2005
10
Three-dimensional esophageal varix model quantification of variceal volume by high-resolution endoluminal US. (10882970)
2000
11
White ball sign after ligation of the esophageal varix bleeding point. (10625824)
2000
12
Surgery for esophageal varix bleeding in cirrhotic patients during the era of liver transplants. (10500632)
1999
13
Two cases of esophageal varix caused by local hyperdynamic state of gastric arteries. (10430342)
1999
14
Post-inflammatory polyps of esophagus: a rare sequela of endoscopic injection sclerotherapy for esophageal varix. (8293932)
1993
15
Results of experimental endoscopic esophageal varix ligation. (3341642)
1988
16
Solitary esophageal varix simulating a neoplasm. (3248091)
1988
17
Endoscopic esophageal varix ligation: preliminary clinical experience. (3259195)
1988
18
Endoscopic esophageal varix ligation: technique and preliminary results in children. (3266244)
1988
19
Critical evaluation of a pressure-sensitive capsule for measurement of esophageal varix pressure. Studies in vitro and in canine mesenteric vessels. (3557007)
1987
20
Esophageal varix hemorrhage and sclerotherapy--animal studies. (3519190)
1986
21
Idiopathic esophageal varix. (6602526)
1983
22
THORACIC DUCT CANNULATION FOR CONTROL OF ESOPHAGEAL VARIX HEMORRHAGE. A PRELIMINARY REPORT. (14226387)
1965
23
GASTRIC SECRETION IN LIVER DISEASE AND ESOPHAGEAL VARIX RUPTURE. (14052010)
1963
24
PATHOGENESIS OF ESOPHAGEAL VARIX RUPTURE. A STUDY BASED ON GROSS AND MICROSCOPIC EXAMINATION OF THE ESOPHAGUS AT THE TIME OF BLEEDING. (14042680)
1963
25
Pathogenesis of esophageal varix rupture. (13762024)
1961
26
The use of surgical pituitrin in the control of esophageal varix bleeding; an experimental study and report of two cases. (13324606)
1956
27
Severe bleeding of an esophageal varix controlled by oxycel. (18132775)
1949
28
The esophageal varix; a report of 115 cases. (20266943)
1947

Genetic Variations for Esophageal Varix

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Expression for genes affiliated with Esophageal Varix

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophageal Varix

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Pathways for genes affiliated with Esophageal Varix

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37NCBI BioSystems Database
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Pathways related to Esophageal Varix according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ALB, F2, AFP

Compounds for genes affiliated with Esophageal Varix

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Esophageal Varix according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1gelofusine449.9SST, ALB
2cefotetan44 1110.8F2, ALB
3dextran 70449.8ALB, F2
4hepaplastin449.8ALB, F2
5cefoperazone44 1110.8ALB, F2
6acenocoumarol44 49 1111.8ALB, F2
7phenprocoumon44 49 1111.8F2, ALB
8spec-t449.8SST, AFP
9phenylbutazone44 1110.8F2, ALB
10hydroxyethyl starch449.7F2, ALB
11antipyrine44 1110.7F2, ALB
12dtpa449.7ALB, SST
13amphetamine44 1110.6F2, SST
14captopril44 28 49 59 1113.4SST, ALB
15terlipressin44 1110.4ALB, F2, SST
16polyethylene glycol449.4AFP, F2, ALB
17thyroxine44 2410.4ALB, SST, AFP
18epinephrine44 11 2411.3AFP, SST, F2
19methotrexate44 49 1111.3ALB, F2, AFP
20naloxone44 49 28 1112.2ALB, SST
21fibrinogen449.1ALB, F2, AFP
22lactate449.0AFP, SST, F2, ALB

GO Terms for genes affiliated with Esophageal Varix

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16Gene Ontology
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Cellular components related to Esophageal Varix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7ALB, F2, SST, AFP

Biological processes related to Esophageal Varix according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surface receptor signaling pathwayGO:0071668.8EVL, F2, SST

Products for genes affiliated with Esophageal Varix

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophageal Varix

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet