MCID: ESP024
MIFTS: 63

Esophagitis malady

Gastrointestinal diseases category
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Summaries for Esophagitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Esophagitis (or oesophagitis) is inflammation of the esophagus. It may be acute or chronic. Acute... more...

MalaCards: Esophagitis, also known as acute esophagitis, is related to eosinophilic esophagitis and eosinophilia. An important gene associated with Esophagitis is CCL26 (chemokine (C-C motif) ligand 26), and among its related pathways are Selected targets of GCR alpha and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drugs omeprazole and sucralfate and the compounds unicap and omalizumab have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and endothelial, and related mouse phenotypes are digestive/alimentary and respiratory system.

Aliases & Classifications for Esophagitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

esophagitis 8 10 45 62
acute esophagitis 8 62


External Ids:

Disease Ontology8 DOID:11963
NCIt40 C9224
ICD9CM27 530.1, 530.10
MeSH35 D004941

Related Diseases for Esophagitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Esophagitis family:

Viral Esophagitis Bacterial Esophagitis

Diseases related to Esophagitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 773)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilic esophagitis31.6IL5, CCL26, CCL11, TSLP
2eosinophilia30.6CCL11, IL5, IL13, CCL26, CCR3, PRG2
3eosinophilic gastroenteritis30.4CCL11, IL5
4food allergy30.3CCL11, IL5, IL13
5pneumonia30.2IL13, IL5, HRH2, CCL11
6respiratory failure30.2CCL11, IL13, CCR3
7asthma30.1IL5, IL13
8schistosomiasis29.8IL13, IL5
9churg-strauss syndrome29.7IL5
10hypereosinophilic syndrome29.6CCL11, IL5, PRG2
11sinusitis29.6IL5, CCL11, PRG2
12keratoconjunctivitis29.6IL13, CCL11, IL5
13bullous pemphigoid29.6IL5, IL13, PRG2, CCL11
14mycosis fungoides29.5CCR3, IL5
15rheumatoid arthritis29.5PRG2, CCL11, CCR3, IL13
16arthritis29.5CCR3, IL13, HRH2
17atopy29.4IL13, IL5, TSLP, CCL11, CCR3, PRG2
18esophageal squamous cell carcinoma11.3
19esophageal cancer11.3
20adenocarcinoma11.1
21esophageal atresia11.1
22barrett's esophagus10.9
23tracheoesophageal fistula10.9
24esophageal disease10.8
25achalasia10.8
26esophageal candidiasis10.8
27candidiasis10.7
28peptic esophagitis10.7
29gastroesophageal reflux disease10.7
30hiatus hernia10.7
31esophageal duplication cyst10.7
32dysphagia10.6
33tuberculosis10.6
34esophageal tuberculosis10.6
35endotheliitis10.6
36duodenitis10.6
37esophageal varix10.5
38leiomyomatosis10.5
39epidermolysis bullosa10.5
40leiomyoma10.5
41mediastinitis10.5
42obesity10.5
43lung cancer10.4
44hypertension10.4
45cardia cancer10.4
46cervicitis10.4
47gastritis10.4
48right aortic arch10.4
49gastric adenocarcinoma10.4
50papilloma10.4

Graphical network of the top 20 diseases related to Esophagitis:



Diseases related to esophagitis

Symptoms for Esophagitis

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Drugs & Therapeutics for Esophagitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Esophagitis

Search NIH Clinical Center for Esophagitis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Esophagitis

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Anatomical Context for Esophagitis

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33MalaCards
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MalaCards organs/tissues related to Esophagitis:

33
Lymph node, Lung, Endothelial, Liver, Colon, Testes, T cells, Smooth muscle, Breast, Bone, Heart, Bone marrow, Brain, Testis, Thyroid, Skin, Spleen, Pituitary, Trachea, Tongue, Prostate, Pancreas, Small intestine, Myeloid, B cells, Kidney, Whole blood, Nk cells, Monocytes, Skeletal muscle

Animal Models for Esophagitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Esophagitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9HRH2, IL13, IL5, TSLP
2MP:00053888.1IL13, IL5, CCL11, CCR3, PRG2, TSLP
3MP:00053978.0TSLP, PRG2, CCR3, CCL11, IL5, IL13
4MP:00053877.8TSLP, PRG2, CCR3, CCL11, IL5, IL13

Publications for Esophagitis

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Sources:
52PubMed
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Articles related to Esophagitis:

(show top 50)    (show all 6867)
idTitleAuthorsYear
1
Randomized study of antiinflammatory and immune-modulatory effects of enteral immunonutrition during concurrent chemoradiotherapy for esophageal cancer. (24274379)
2014
2
A meta-analysis of the association between the hOGG1 Ser326Cys polymorphism and the risk of esophageal squamous cell carcinoma. (23762419)
2013
3
Nomogram for predicting the benefit of neoadjuvant chemoradiotherapy for patients with esophageal cancer: A SEER-Medicare analysis. (24194477)
2013
4
Acquired factor V inhibitor developing in a patient with esophageal squamous cell carcinoma. (23080366)
2013
5
Co-expression of AQP3 and AQP5 in esophageal squamous cell carcinoma correlates with aggressive tumor progression and poor prognosis. (23797770)
2013
6
Metallic expandable stents in the management of malignant tracheal stenosis due to esophageal cancer with lymph node metastasis. (24179541)
2013
7
Are major basic protein, eotaxin-3 and leukotriene enzyme staining useful for diagnosing eosinophilic esophagitis? (Am j gastroenterol 2012;107:1503-1511). (23350059)
2013
8
Prognostic significance of p21 expression in patients with esophageal squamous cell carcinoma. (24123000)
2013
9
Treatment and outcome of young patients with esophageal cancer in the Netherlands. (24338660)
2013
10
Esophageal atresia, small omphalocele and ileal prolapse through a patent omphalomesenteric duct: a methamizole embryopathy? (23845657)
2013
11
Expression and clinical significance of BRCA1 in human esophageal squamous cell carcinoma]. (23336376)
2012
12
Relationship between HLA-G gene polymorphism and the susceptibility of esophageal cancer in Kazakh and Han nationality in Xinjiang. (22080860)
2012
13
Combining proteomics, serum biomarkers and bioinformatics to discriminate between esophageal squamous cell carcinoma and pre-cancerous lesion. (23225851)
2012
14
A pilot study of laparoscopic gastric pull-up by using the natural orifice translumenal endoscopic surgery technique: a novel procedure for treating long-gap esophageal atresia (type a). (21859341)
2011
15
Phorbol 12,13 dibutyrate behaves in a tumor-inhibitory manner in esophageal adenocarcinoma cell lines. (21595773)
2011
16
Correlation between gp96 expression and the surgical outcome in patients with esophageal squamous cell carcinoma. (20839070)
2011
17
Esophagitis dissecans superficialis. (21549372)
2011
18
Expression and clinical significance of the DNA repair enzyme MYH in esophageal squamous cell carcinoma. (22977630)
2011
19
Overexpression of Pim-1 is associated with poor prognosis in patients with esophageal squamous cell carcinoma. (20544717)
2010
20
Metastatic esophageal adenocarcinoma presenting as an external auditory canal mass. (20115997)
2010
21
RAD001 offers a therapeutic intervention through inhibition of mTOR as a potential strategy for esophageal cancer. (20204306)
2010
22
Primary localized cutaneous nodular amyloidosis associated with CREST (calcinosis, Raynaud's phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia) syndrome. (20465653)
2010
23
Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis. (20647328)
2010
24
Severe dysphagia in children with eosinophilic esophagitis and esophageal stricture: an indication for balloon dilation? (19934772)
2010
25
Genome-wide catalogue of chromosomal aberrations in barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis. (20651033)
2010
26
Esophageal atresia/tracheoesophageal fistula in very low-birth-weight neonates: improved outcomes with staged repair. (20006009)
2009
27
A case-control study of sociodemographic and geographic characteristics of 335 children with eosinophilic esophagitis. (19118642)
2009
28
HOXA13 promotes cancer cell growth and predicts poor survival of patients with esophageal squamous cell carcinoma. (19491265)
2009
29
TGFB1 and TGFBR2 functional polymorphisms and risk of esophageal squamous cell carcinoma: a case-control analysis in a Chinese population. (17680270)
2008
30
Esophageal schwannoma: report of a case. (17522770)
2007
31
High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model. (17868414)
2007
32
Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma. (17099870)
2007
33
Expression of ezrin and CD44-v6 in human esophageal squamous cell carcinoma and its clinical significance]. (18246799)
2007
34
Esophageal duplication cyst--a guest case in robotic and computer-assisted surgery from the University of Nebraska Medical Center. (17415307)
2006
35
DNA methylation in esophageal diseases including cancer: special reference to hMLH1 gene promoter status. (16724696)
2006
36
Iatrogenic esophageal perforation that may sometimes masquerade as esophageal atresia. (15856590)
2005
37
Role for the double-stranded RNA-activated protein kinase PKR in Ad-TNF-alpha gene therapy in esophageal cancer. (16153435)
2005
38
Prevalence and predictors of esophageal varices in patients with primary sclerosing cholangitis. (14752839)
2004
39
A case-control study on the polymorphisms of methylenetetrahydrofolate reductase 1298A-->C and susceptibility of esophageal cancer]. (15231206)
2004
40
Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma. (15069682)
2004
41
Clinicopathological significance of human macrophage metalloelastase expression in esophageal squamous cell carcinoma. (12417793)
2002
42
Effect of somatostatin on lower esophageal sphincter characteristics in man. (11063148)
2000
43
Down-regulation of nerve growth factor in poorly differentiated and advanced human esophageal cancer. (10769644)
2000
44
Prevalence of benign esophageal disease in the Danish population, with special reference to pulmonary disease and risk factors. (8813455)
1996
45
Esophageal duplication cyst with esophageal web and tracheoesophageal fistula. (8811570)
1996
46
Simple technique for proximal pouch mobilization and circular myotomy in cases of esophageal atresia with tracheoesophageal fistula. (7807338)
1994
47
Refractory esophageal candidiasis associated with a low molecular weight plasma inhibitor of T-lymphocyte function. (3487248)
1986
48
Transient esophageal dysfunction mimicking megaesophagus in three dogs. (6477681)
1984
49
Persistent right aortic arch with associated esophageal dilatation in dogs. (14365183)
1955
50
Chronic peptic esophagitis. (13267570)
1955

Variations for Esophagitis

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Expression for genes affiliated with Esophagitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophagitis

Search GEO for disease gene expression data for Esophagitis.

Pathways for genes affiliated with Esophagitis

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Sources:
50PathCards, 12EMD Millipore, 54R&D Systems, 53QIAGEN, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 60Thomson Reuters
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Pathways related to Esophagitis according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IL5, CCL11
29.8IL5, IL13
39.8IL13, IL5
49.8IL5, IL13
59.8IL13, IL5
69.6CCL11, TSLP
79.6CCL26, CCL11, IL5
8
Show member pathways
9.5CCR3, CCL26, CCL11
9
Show member pathways
9.5CCL11, CCL26, CCR3
10
Show member pathways
9.5CCL11, CCL26, CCR3
11
Show member pathways
9.5CCL11, CCL26, CCR3
12
Show member pathways
Type III interferon signaling38
9.3TSLP, IL5, IL13
13
Show member pathways
9.2IL13, IL5, CCL11, CCL26
14
Show member pathways
9.0PRG2, CCL11, IL5, IL13
15
Show member pathways
9.0CCL11, CCL26, CCR3, PRG2
16
Show member pathways
8.9CCR3, CCL26, CCL11, IL5, IL13
17
Show member pathways
8.9CCR3, CCL26, CCL11, IL5, IL13
18
Show member pathways
8.3IL13, IL5, CCL11, CCL26, CCR3, TSLP
19
Show member pathways
8.3PRG2, CCR3, CCL26, CCL11, IL5, IL13

Compounds for genes affiliated with Esophagitis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 51PharmGKB, 3BitterDB
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Compounds related to Esophagitis according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1unicap4510.2CCL11, IL5
2omalizumab45 1111.2IL5, IL13
3sodium cromoglycate4510.1CCL11, IL5
4ovomucoid4510.1IL13, IL5
5lte44510.1CCL11, IL5
65-oxoete4510.1CCL11, IL5
7cetirizine45 29 24 1113.1CCL11, IL5
8roxithromycin45 29 1112.1CCL11, IL5
9epinastine45 1111.0IL5, HRH2
10mcp 14510.0CCR3, IL5
114-ipp619.9IL5, IL13
12salmeterol45 51 29 1112.9IL13, IL5, CCL11
13montelukast45 51 29 1112.9IL13, IL5, CCL11
14budesonide45 51 1111.9IL13, IL5, CCL11
15fluticasone propionate45 51 61 1112.9CCL11, IL5, IL13
16rolipram45 61 2911.9IL13, IL5, CCL11
17git 27619.9IL5, IL13
18ltd4459.9CCR3, IL5, IL13
19leukotriene b445 61 2411.8IL13, IL5, CCL11
20ccl445 2910.8CCR3, CCL11, IL13
21clarithromycin45 1110.8HRH2, IL5, CCL11
22prednisolone45 29 1111.8IL13, IL5, CCL11
23diclofenac45 29 51 1112.8IL5, IL13, HRH2
24pranlukast45 29 1111.8CCL11, IL5
25theophylline45 29 24 1112.8HRH2, IL13, IL5
26ccl345 2910.6CCR3, CCL26, CCL11, IL13
27glatiramer acetate45 1110.5IL13, IL5
28salbutamol45 51 29 24 1113.5CCL11, IL5, IL13, HRH2
29herbimycin a45 6110.5IL5, CCL11, CCR3
30ltc4459.4IL13, IL5, CCL11, PRG2
31methacholine45 51 1111.4IL13, IL5, CCL11, PRG2
32fmlp459.4PRG2, CCL11, IL5, IL13
33indomethacin45 29 61 1112.4IL13, IL5, CCL11, PRG2
34pge2459.4CCL11, IL5, IL13, HRH2
35endotoxin459.4HRH2, IL13, CCL11
36genistein45 29 61 3 24 1114.3IL5, CCL11, CCR3, PRG2
37rantes459.3CCR3, CCL26, CCL11, IL5, IL13
38actinomycin d459.3IL13, CCL11, CCR3, PRG2
39superoxide45 2410.2PRG2, CCL26, CCL11, HRH2
40adenylate459.2HRH2, IL13, IL5, CCR3
41thymidine45 2410.1CCR3, CCL11, IL5, IL13, HRH2
42pgd2459.1PRG2, CCR3, CCL11, IL5, IL13
43heparin45 29 24 1112.0IL13, IL5, CCL11, CCR3, PRG2
44cysteine459.0PRG2, CCR3, CCL26, IL5, IL13
45allergens458.9TSLP, PRG2, CCL11, IL5, IL13
46oxygen45 249.9PRG2, CCR3, CCL26, CCL11, HRH2
47tarc458.8IL13, IL5, CCL11, CCL26, CCR3, TSLP
48histamine45 29 2410.6PRG2, CCR3, CCL11, IL5, IL13, HRH2
49tyrosine458.4TSLP, PRG2, CCR3, CCL11, IL5, IL13
50retinoic acid45 249.2SPRR3, PRG2, CCR3, CCL11, IL5, IL13

GO Terms for genes affiliated with Esophagitis

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Sources:
16Gene Ontology
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Cellular components related to Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7IL13, IL5, CCL11, CCL26, TSLP

Biological processes related to Esophagitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of actin filament polymerizationGO:0308389.9CCL11, CCL26
2positive regulation of Rac GTPase activityGO:0328559.8CCL26, CCL11
3positive regulation of endothelial cell proliferationGO:0019389.6CCR3, CCL26, CCL11
4positive regulation of B cell proliferationGO:0308909.5IL13, IL5
5chemotaxisGO:0069359.5CCL11, CCL26, CCR3
6inflammatory responseGO:0069549.0CCR3, CCL26, CCL11, IL5, IL13
7immune responseGO:0069558.4HRH2, IL13, IL5, CCL11, CCL26, PRG2

Molecular functions related to Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.9CCL11, CCL26
2cytokine activityGO:0051259.0IL13, IL5, TSLP

Products for genes affiliated with Esophagitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophagitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet