MCID: ESP024
MIFTS: 60

Esophagitis malady

Summaries for Esophagitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Esophagitis (or oesophagitis) is inflammation of the esophagus. It may be acute or chronic. Acute... more...

MalaCards: Esophagitis, also known as acute esophagitis, is related to squamous cell carcinoma and esophageal cancer. An important gene associated with Esophagitis is DEC1 (deleted in esophageal cancer 1), and among its related pathways are Signaling events mediated by the Hedgehog family and Glypican 3 network. The drugs omeprazole and sucralfate and the compound cyclopamine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and endothelial, and related mouse phenotypes are digestive/alimentary and integument.

Aliases & Classifications for Esophagitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

esophagitis 8 10 44 60
acute esophagitis 8 60


External Ids:

Disease Ontology8 DOID:11963
ICD9CM27 530.1, 530.10
MeSH34 D004941
NCIt39 C9224

Related Diseases for Esophagitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Esophagitis family:

Bacterial Esophagitis Viral Esophagitis

Diseases related to Esophagitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 694)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.9FHIT, CTAG1B, CTSB, KDM4C, KRT4, PTCH1
2esophageal cancer31.9DLEC1, C2orf40, ATP4A, FHIT
3adenocarcinoma31.6FHIT, CTAG1B, CTSB, KRT4, PTCH1
4lung cancer30.7DLEC1, FHIT
5stomach cancer30.2FHIT, CTAG1B, CTSB, PTCH1
6breast cancer30.0FHIT, CTAG1B, CTSB, DLEC1, PTCH1
7transitional cell carcinoma29.9FHIT, CTAG1B, CTSB, PTCH1
8esophageal squamous cell carcinoma29.8DEC1, LZTS1
9prostate cancer29.7CTAG1B, CTSB, DLEC1, TMPRSS11A
10pallister-hall syndrome29.7SHH
11bladder carcinoma29.5LZTS1, FHIT, CTAG1B, PTCH1
12esophageal atresia11.1
13eosinophilic esophagitis11.1
14esophageal disease11.0
15barrett's esophagus10.9
16barrett's adenocarcinoma10.8
17achalasia10.8
18esophagus adenocarcinoma10.8
19esophageal candidiasis10.7
20peptic esophagitis10.7
21candidiasis10.7
22gastroesophageal reflux disease10.7
23hiatus hernia10.7
24esophageal tuberculosis10.6
25gastric adenocarcinoma10.6
26tuberculosis10.6
27duodenitis10.5
28esophageal varix10.5
29lymph node cancer10.5
30eosinophilia10.4
31gastric squamous cell carcinoma10.4
32leiomyomatosis10.4
33epidermolysis bullosa10.4
34thoracic cancer10.4
35cardia cancer10.4
36leiomyoma10.4
37mediastinitis10.4
38obesity10.4
39hypertension10.4
40cervicitis10.4
41gastritis10.4
42peptic ulcer10.4
43small cell carcinoma10.3
44liver cirrhosis10.3
45papilloma10.3
46portal hypertension10.3
47esophageal atresia/tracheoesophageal fistula10.3
48tylosis with esophageal cancer10.3
49vacterl association10.3
50duodenal ulcer10.3

Graphical network of the top 20 diseases related to Esophagitis:



Diseases related to esophagitis

Clinical Features for Esophagitis

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Drugs & Therapeutics for Esophagitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Esophagitis

Drug clinical trials:

Search ClinicalTrials for Esophagitis

Search NIH Clinical Center for Esophagitis

Search CenterWatch for Esophagitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Esophagitis

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Anatomical Context for Esophagitis

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32MalaCards
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MalaCards organs/tissues related to Esophagitis:

32
Lymph node, Lung, Endothelial, Liver, Colon, Testes, T cells, Smooth muscle, Breast, Bone, Spleen, Brain, Heart, Bone marrow, Thyroid, Testis, Skin, Pituitary, Trachea, Prostate, Tongue, B cells, Small intestine, Myeloid, Pancreas, Kidney, Whole blood, Monocytes, Nk cells, Skeletal muscle

Animal Models for Esophagitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Esophagitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538111.7PTCH1, KRT4, SHH, ATP4A, CTSB, FHIT
2MP:001077111.6PTCH1, FHIT, CTSB, SHH, CLDN6, KDM4C

Publications for Esophagitis

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50PubMed
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Articles related to Esophagitis:

(show top 50)    (show all 6937)
idTitleAuthorsYear
1
Clinicopathological and prognostic significance of hypoxia-inducible factor-1I+ in esophageal squamous cell carcinoma: a meta-analysis. (24425106)
2014
2
SLC39A6 affects esophageal squamous cell carcinoma survival. (23847371)
2013
3
Esophageal adenocarcinoma with solitary renal metastasis. (23196387)
2013
4
Dietary intake of lignans and risk of esophageal and gastric adenocarcinoma: a cohort study in Sweden. (23195991)
2013
5
The significance of the HER-2 status in esophageal adenocarcinoma for survival: an immunohistochemical and an in situ hybridization study. (23334118)
2013
6
A case of esophageal squamous cell carcinoma with positive HPV 11. (23195756)
2013
7
Extended lymphadenectomy in esophageal cancer is debatable. (23553174)
2013
8
Three-arm phase III trial comparing cisplatin plus 5-FU (CF) versus docetaxel, cisplatin plus 5-FU (DCF) versus radiotherapy with CF (CF-RT) as preoperative therapy for locally advanced esophageal cancer (JCOG1109, NExT study). (23625063)
2013
9
Esophageal cancer recurrence patterns and implications for surveillance. (24389438)
2013
10
Poor oral hygiene and risk of esophageal squamous cell carcinoma in Kashmir. (23900216)
2013
11
Esophageal cancer alters the expression of nuclear pore complex binding protein Hsc70 and eIF5A-1. (23539416)
2013
12
Foscarnet-resistant cytomegalovirus esophagitis with stricturing. (23466529)
2013
13
Surgical advances in the fetus and neonate: esophageal atresia. (22682384)
2012
14
Comparison of 2 expandable stents for malignant esophageal disease: a randomized controlled trial. (22726466)
2012
15
Eosinophilic esophagitis: dilate or medicate? A cost analysis model of the choice of initial therapy. (22947137)
2012
16
Eosinophilic esophagitis with pseudodiverticulosis: a rare coincidence. (22396287)
2012
17
Prognostic significance of phosphorylated RON in esophageal squamous cell carcinoma. (22086736)
2012
18
A pilot study of laparoscopic gastric pull-up by using the natural orifice translumenal endoscopic surgery technique: a novel procedure for treating long-gap esophageal atresia (type a). (21859341)
2011
19
Clinical significance of Wnt-induced secreted protein-1 (WISP-1/CCN4) in esophageal squamous cell carcinoma. (21498727)
2011
20
Purulent pericarditis in patient with esophageal cancer presenting with cardiac tamponade. (19272728)
2011
21
Fully covered self-expandable metal stents for benign esophageal disease: a multicenter retrospective case series of 31 patients. (21549373)
2011
22
Chronic cough and eosinophilic esophagitis: an uncommon association. (21960955)
2011
23
A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous esophageal/gastric cardia cancer in a Chinese high-risk area. (20603233)
2010
24
Shunting and nonshunting procedures for the treatment of esophageal varices in patients with idiopathic portal hypertension. (21410046)
2010
25
The benefit of stay sutures during thoracoscopic esophagoesophagostomy in patients with esophageal atresia: a technical report. (20182751)
2010
26
Esophageal dilation: simple and effective treatment for adults with eosinophilic esophagitis and esophageal rings and narrowing. (20353444)
2010
27
Extrathoracic esophageal elongation (Kimura's technique): a feasible option for the treatment of patients with complex esophageal atresia. (20006042)
2009
28
The risk of esophageal resection after esophagomyotomy for achalasia. (19379905)
2009
29
Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma. (18831746)
2008
30
Expression of HLA-G is associated with prognosis in esophageal squamous cell carcinoma. (18024326)
2007
31
EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I. (16210470)
2006
32
HER-2 overexpression (3+) in patients with squamous cell esophageal carcinoma correlates with poorer survival. (16866851)
2006
33
Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma. (16186806)
2006
34
Proposal of a novel method to evaluate anastomotic tension in esophageal atresia with a distal tracheoesophageal fistula. (16177921)
2005
35
Flavopiridol reduces malignant transformation of the esophageal mucosa in p27 knockout mice. (15674336)
2005
36
Common single nucleotide polymorphism of hypoxia-inducible factor-1alpha and its impact on the clinicopathological features of esophageal squamous cell carcinoma. (16246222)
2005
37
A case-control study on the polymorphisms of methylenetetrahydrofolate reductase 1298A-->C and susceptibility of esophageal cancer]. (15231206)
2004
38
In situ analysis of p16/INK4 promoter hypermethylation in esophageal carcinoma and gastric carcinoma. (15612883)
2004
39
E-cadherin expression in patients with esophageal squamous cell carcinoma: promoter hypermethylation, Snail overexpression, and clinicopathologic implications. (15272533)
2004
40
Association of the thymidylate synthase polymorphisms with esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma. (15284183)
2004
41
Increased expression of c-Ski as a co-repressor in transforming growth factor-beta signaling correlates with progression of esophageal squamous cell carcinoma. (14712482)
2004
42
Treatment of a patient with advanced esophageal cancer with a combination of mitomycin C and capecitabine: activation of the thymidine phosphorylase as active principle? (12771525)
2003
43
A case of primary esophageal tuberculosis diagnosed by identification of Mycobacteria in paraffin-embedded esophageal biopsy specimens by polymerase chain reaction. (12560925)
2003
44
Clinicopathological significance of human macrophage metalloelastase expression in esophageal squamous cell carcinoma. (12417793)
2002
45
Effect of long-term, continuous versus alternate-day omeprazole therapy on serum gastrin in patients treated for reflux esophagitis. (11418787)
2001
46
Esophageal tuberculosis: a rare presentation with massive hematemesis. (10617037)
1999
47
Positive correlation between p27Kip1 expression and progression of human esophageal squamous cell carcinoma. (9699540)
1998
48
Overexpression of cyclin D1 in rat esophageal carcinogenesis model. (9045891)
1997
49
Expression of growth factors and their receptors in human esophageal carcinomas: regulation of expression by epidermal growth factor and transforming growth factor alpha. (8491760)
1993
50
Stenosing peptic esophagitis; with a report of the results of treatment in 22 cases. (13015614)
1951

Genetic Variations for Esophagitis

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Expression for genes affiliated with Esophagitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophagitis

Search GEO for disease gene expression data for Esophagitis.

Pathways for genes affiliated with Esophagitis

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37NCBI BioSystems Database
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Pathways related to Esophagitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9PTCH1, SHH
210.9PTCH1, SHH

Compounds for genes affiliated with Esophagitis

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44Novoseek, 59Tocris Bioscience
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Compounds related to Esophagitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclopamine44 5911.9PTCH1, SHH

GO Terms for genes affiliated with Esophagitis

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16Gene Ontology
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Biological processes related to Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somite developmentGO:06105310.9PTCH1, SHH
2spinal cord motor neuron differentiationGO:02152210.9PTCH1, SHH
3renal system developmentGO:07200110.8PTCH1, SHH
4negative regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243510.6SHH, FHIT

Molecular functions related to Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1patched bindingGO:00511310.9PTCH1, SHH

Products for genes affiliated with Esophagitis

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Esophagitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet