MCID: ESP024
MIFTS: 61

Esophagitis malady

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Esophagitis

Aliases & Descriptions for Esophagitis:

Name: Esophagitis 12 29 52 42 14 69
Acute Esophagitis 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11963
ICD10 33 K20 K20.9
ICD9CM 35 530.1 530.10
MeSH 42 D004941
NCIt 47 C9224
UMLS 69 C0014868

Summaries for Esophagitis

MalaCards based summary : Esophagitis, also known as acute esophagitis, is related to esophagus lymphoma and tuberculosis, and has symptoms including pain in esophagus (finding) An important gene associated with Esophagitis is CCL26 (C-C Motif Chemokine Ligand 26), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Budesonide and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and endothelial, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 71 Esophagitis (or oesophagitis) is inflammation of the esophagus. It may be acute or chronic. Acute... more...

Related Diseases for Esophagitis

Diseases in the Esophagitis family:

Bacterial Esophagitis Viral Esophagitis

Diseases related to Esophagitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 796)
id Related Disease Score Top Affiliating Genes
1 esophagus lymphoma 31.2 CXCL8 IL6 TNF
2 tuberculosis 30.6 IL1B IL6 TNF
3 burns 29.9 CXCL8 IL6 TNF
4 nasopharyngitis 29.9 CXCL8 IL1B IL6 TNF
5 epidermolysis bullosa 29.7 CCL11 IL13 IL5 TNF TSLP
6 neuropathy 29.6 CXCL8 IL1B IL6 TNF
7 oral squamous cell carcinoma 29.5 EGFR PTGS2 TP53
8 smooth muscle tumor 29.4 IL13 IL5 IL6
9 alcoholic hepatitis 29.3 CXCL8 IL6 TNF
10 intussusception 29.3 IL1B TNF
11 choroiditis 29.3 CXCL8 IL1B IL6 TNF
12 dextrocardia 29.2 IL1B IL6 TNF
13 lymphoblastic leukemia 29.0 CCL11 IL13 IL5
14 crohn's colitis 28.8 CCR3 IL6 TNF
15 birth defects 28.8 CCL11 CXCL8 IL13 IL5
16 rheumatoid arthritis 28.6 CXCL8 IL1B IL6 PTGS2 TNF
17 colon adenocarcinoma 28.5 CCL11 CXCL8 IL1B IL5 IL6 TNF
18 collagenous colitis 28.5 CCR3 CXCL8 IL1B IL6 PTGS2 TNF
19 esophageal cancer 12.4
20 tylosis with esophageal cancer 12.2
21 esophageal candidiasis 12.2
22 esophageal atresia 12.2
23 barrett esophagus/esophageal adenocarcinoma 12.1
24 esophageal disease 12.1
25 esophageal atresia/tracheoesophageal fistula 12.1
26 esophagitis, eosinophilic, 1 12.0
27 esophageal adenosquamous carcinoma 12.0
28 esophageal adenoid cystic carcinoma 12.0
29 esophageal varix 12.0
30 peptic esophagitis 11.9
31 achalasia, familial esophageal 11.9
32 viral esophagitis 11.8
33 esophageal diverticulosis 11.8
34 fungal esophagitis 11.8
35 esophageal basaloid squamous cell carcinoma 11.8
36 bacterial esophagitis 11.8
37 esophageal tuberculosis 11.8
38 proton-pump inhibitor-responsive esophageal eosinophilia 11.8
39 esophageal lipoma 11.8
40 esophageal duplication cyst 11.8
41 esophageal neuroendocrine tumor 11.8
42 feingold syndrome 11.8
43 esophageal leukoplakia 11.7
44 achalasia 11.7
45 congenital esophageal diverticulum 11.7
46 tracheoesophageal fistula with or without esophageal atresia 11.7
47 mucoepidermoid esophageal carcinoma 11.7
48 leiomyomatosis, esophageal and vulval, with nephropathy 11.7
49 anophthalmia-esophageal atresia-genital abnormalities syndrome 11.7
50 gastroesophageal reflux 11.7

Comorbidity relations with Esophagitis via Phenotypic Disease Network (PDN): (show top 50) (show all 111)


Active Peptic Ulcer Disease Acute Cystitis
Acute Maxillary Sinusitis Acute Pancreatitis
Adrenal Cortical Hypofunction Alcoholic Gastritis
Allergic Rhinitis Anxiety Disorder
Atrophic Gastritis Basilar Artery Insufficiency
Benign Essential Hypertension Benign Paroxysmal Positional Nystagmus
Bronchiectasis Bronchitis
Bronchopneumonia Cerebrovascular Disease
Cholecystitis Cholestasis
Chronic Kidney Failure Chronic Maxillary Sinusitis
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Chronic Rhinitis Chylomicron Retention Disease
Conversion Disorder Cystitis
Deficiency Anemia Dependent Personality Disorder
Dermatomycosis Diabetic Polyneuropathy
Duodenitis Dyskinesia of Esophagus
Dysthymic Disorder Esophageal Cancer
Esophageal Candidiasis Esophageal Disease
Esophageal Varix First-Degree Atrioventricular Block
Gallbladder Disease Gastrin Secretion Abnormality
Gastritis, Familial Giant Hypertrophic Gastroesophageal Reflux
Generalized Anxiety Disorder Generalized Atherosclerosis
Heart Disease Hepatitis
Hyperlipidemia, Familial Combined Hyperlipoproteinemia Type Iv
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis

Graphical network of the top 20 diseases related to Esophagitis:



Diseases related to Esophagitis

Symptoms & Phenotypes for Esophagitis

UMLS symptoms related to Esophagitis:


pain in esophagus (finding)

MGI Mouse Phenotypes related to Esophagitis:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.27 CCL11 CCR3 EGFR IL13 IL1B IL5
2 homeostasis/metabolism MP:0005376 10.25 CCR3 EGFR HRH2 IL13 IL1B IL5
3 immune system MP:0005387 10.22 IL13 IL1B IL5 IL6 PTGS2 SOD2
4 digestive/alimentary MP:0005381 10.15 TSLP EGFR HRH2 IL13 IL5 IL6
5 endocrine/exocrine gland MP:0005379 10.08 EGFR HRH2 IL13 IL6 PTGS2 STAT6
6 integument MP:0010771 10.07 EGFR IL13 IL1B IL6 PTGS2 SOD2
7 adipose tissue MP:0005375 9.99 EGFR IL6 PTGS2 SOD2 TNF TP53
8 liver/biliary system MP:0005370 9.92 EGFR IL5 IL6 PTGS2 SOD2 STAT6
9 neoplasm MP:0002006 9.81 EGFR IL1B IL5 IL6 PTGS2 SOD2
10 muscle MP:0005369 9.8 EGFR IL13 IL6 PTGS2 SOD2 TNF
11 reproductive system MP:0005389 9.61 TNF TP53 EGFR IL13 IL5 IL6
12 respiratory system MP:0005388 9.36 TNF TP53 TSLP CCL11 CCR3 EGFR

Drugs & Therapeutics for Esophagitis

Drugs for Esophagitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 261)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 4,Phase 3,Phase 2 51333-22-3 63006 5281004
2
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 73590-58-6 4594
3
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Pantoprazole Approved Phase 4,Phase 3,Phase 2 102625-70-7 4679
6
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 103577-45-3 3883
7
Rabeprazole Approved, Investigational Phase 4,Phase 3,Phase 2 117976-89-3 5029
8
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 119141-88-7 4594 9579578
9
Pemetrexed Approved, Investigational Phase 4,Phase 3,Phase 2 150399-23-8, 137281-23-3 446556 60843
10
Ranitidine Approved Phase 4,Phase 1 66357-59-3, 66357-35-5 3001055
11 Trimebutine Approved Phase 4 39133-31-8
12
Verapamil Approved Phase 4 52-53-9 2520
13
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
15
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 54575, 6560146 143
16
Maleic acid Experimental Phase 4 110-16-7 444266
17 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1
18 Cromolyn Sodium Phase 4
19 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
20 Anti-Allergic Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Autonomic Agents Phase 4,Phase 3,Phase 2
23 Bronchodilator Agents Phase 4,Phase 3,Phase 2
24 Dermatologic Agents Phase 4,Phase 3,Phase 2
25
Fluticasone Phase 4,Phase 3,Phase 2 90566-53-3, 80474-14-2 62924 22833648
26 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
27 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
28 Hormones Phase 4,Phase 3,Phase 2,Phase 1
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
30 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
31 Antacids Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
32 Antiemetics Phase 4
33 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Dopamine Agents Phase 4
35 Dopamine Antagonists Phase 4
36 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
38
Proton pump inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39
Dexlansoprazole Phase 4,Phase 3,Phase 1,Phase 2 138530-94-6, 103577-45-3 9578005
40 Protective Agents Phase 4,Phase 2,Phase 1
41 Omeprazole, sodium bicarbonate drug combination Phase 4
42 Antioxidants Phase 4,Phase 2,Phase 1
43 Rebamipide Phase 4 90098-04-7
44 Pepsin A Phase 4
45
Bilirubin Phase 4 635-65-4 5280352
46 Folic Acid Antagonists Phase 4,Phase 3,Phase 2
47 N-Methylaspartate Phase 4
48 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
49 Vitamin B Complex Phase 4,Phase 3,Phase 2
50 Ranitidine bismuth citrate Phase 4,Phase 1

Interventional clinical trials:

(show top 50) (show all 353)
id Name Status NCT ID Phase
1 Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis Unknown status NCT02371941 Phase 4
2 Dietetic Versus Topical Steroids for Pediatric Eosinophilic Esophagitis Unknown status NCT01846962 Phase 4
3 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
4 Research of Efficient Use of Omeprazole in Combination With Domperidone in Gastroesophageal Reflux Disease of Mild to Moderate Severity Unknown status NCT02140073 Phase 4
5 Intravenous (IV) Pantoprazole in Erosive Esophagitis Completed NCT00133770 Phase 4
6 An Efficacy Study to Compare the Treatment Effects of Rabeprazole and Lansoprazole Depending on the Genotyping of CYP2C19 in Treating Reflux Esophagitis Completed NCT01008696 Phase 4
7 A Multicenter, Randomized, Double Blind, Double Dummy, Parallel-Group Efficacy Study Comparing 8 Weeks of Treatment With Esomeprazole Magnesium (40mg qd) to Lansoprazole (30mg qd) for the Healing of Erosive Esophagitis in Patients With Moderate or Severe Completed NCT00641602 Phase 4
8 Rate of Complete Symptom Relief, Prevention of Symptom Relapse: Grades A and B Esophagitis of Esomeprazole Therapy Completed NCT01874535 Phase 4
9 Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot Study Completed NCT00693225 Phase 4
10 NEXIUM® in the Treatment of Moderate and Severe Erosive Esophagitis Completed NCT00206180 Phase 4
11 The Study to Evaluate Efficacy and Safety of Newrabell® Tab.(Rabeprazole Sodium) 10mg b.i.d in Refractory GERD Completed NCT01860482 Phase 4
12 A Study to Evaluate REbamiPide as an Adjuvant Regimen to Heal erosIve Reflux Esophagitis Completed NCT02755753 Phase 4
13 Esomeprazole for Treatment of GERD in Pediatric Patients Completed NCT00228527 Phase 4
14 Multicenter, Randomized, Double-Blind, Double-Dummy, Parallel-Group Comparison of the Remission Rates of Once Daily Treatment With Esomeprazole 20mg and Lansoprazole 15mg for 6 Months in Patients Whose EE Has Been Healed Completed NCT00644735 Phase 4
15 An Open-Label Study of Once-Daily Oral Administration of Esomeprazole 40 mg in Patients With Symptoms of Gastroesophageal Reflux Disease (GERD) Completed NCT00242736 Phase 4
16 Role of Pepsin Assay in Wheezy Infants Completed NCT02685436 Phase 4
17 Dexlansoprazole in Asian Participants With Gastroesophageal Reflux Disease Completed NCT02351960 Phase 4
18 To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole Completed NCT01397084 Phase 4
19 The Prospective Study on the Effect of Ilaprazole in Non-erosive Reflux Disease Patients; Focused on Histologic Findings and Inflammatory Biomarker Completed NCT02666976 Phase 4
20 Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected Patients Completed NCT00574925 Phase 4
21 A Study of Rabeprazole and Pantoprazole on Stomach Acid and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease (GERD) and a History of Nighttime Heartburn Completed NCT00237367 Phase 4
22 Do Laryngeal Tissue Changes in Patients Suspected of Having Laryngopharyngeal Reflux Predict Response to Treatment? Completed NCT00444145 Phase 4
23 Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD) Completed NCT00872755 Phase 4
24 Chemotherapy for Patients With Non-Small Cell Lung Cancer Completed NCT00380718 Phase 4
25 Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole Recruiting NCT02986685 Phase 4
26 Vonoprazan Study of Investigating the Effect on Sleep Disturbance Associated With Reflux Esophagitis- Exploratory Evaluation Recruiting NCT03116841 Phase 4
27 An Open-Label Trial of Dexlansoprazole 60mg for the Relief of Heartburn During the Fasting Month of Ramadan Recruiting NCT03079050 Phase 4
28 Prevention of Silent Cerebral Thromboembolism by Oral Anticoagulation With Dabigatran After Pulmonary Vein Isolation for Atrial Fibrillation Recruiting NCT02067182 Phase 4
29 Vonoprazan Study in Patients With Erosive Esophagitis to Evaluate Long-term Safety Active, not recruiting NCT02679508 Phase 4
30 Transoral Incisionless Fundoplication (TIF) Versus Sham for Treatment of Gastroesophageal Reflux Disease (GERD) Active, not recruiting NCT01110811 Phase 4
31 Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagitis Enrolling by invitation NCT02759393 Phase 4
32 The Frequency of Eosinophilic Esophagitis in Patients With Heartburn That is Refractory to Proton Pump Inhibitors Terminated NCT01404832 Phase 4
33 Lansoprazole Preventing Gastroduodenal Stress Ulcerations Terminated NCT00220909 Phase 4
34 Dexilant Treatment in Gastrointestinal Reflux Disease (GERD Related Non Cardiac Chest Pain Withdrawn NCT01637571 Phase 4
35 A Trial of Reconstruction After Distal Gastrectomy for Gastric Cancer Unknown status NCT01065688 Phase 3
36 Endoscopic Fundoplication Versus Proton Pump Inhibitors for GERD Treatment Unknown status NCT00857597 Phase 3
37 Reflux Esophagitis Phase III Study (Initial Treatment) Completed NCT00633932 Phase 3
38 Reflux Esophagitis Phase III Study (Maintenance Treatment) Completed NCT00634114 Phase 3
39 Efficacy and Safety of Dexlansoprazole MR and Lansoprazole on Healing of Erosive Esophagitis Completed NCT00251719 Phase 3
40 Efficacy and Safety of Dexlansoprazole MR and Lansoprazole on Healing of Erosive Esophagitis Completed NCT00251693 Phase 3
41 Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Erosive Esophagitis Completed NCT02456935 Phase 3
42 Efficacy and Safety of Dexlansoprazole MR on Maintaining Healing in Subjects With Healed Erosive Esophagitis Completed NCT00255164 Phase 3
43 Comparison of Dexlansoprazole MR to Placebo on the Ability to Maintain Healing in Subjects With Healed Erosive Esophagitis Completed NCT00255151 Phase 3
44 Efficacy and Safety of Dexlansoprazole MR Compared to Placebo on Maintaining Healing in Subjects With Healed Erosive Esophagitis Completed NCT00321737 Phase 3
45 Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Erosive Esophagitis Completed NCT01452698 Phase 3
46 Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Maintenance Treatment of Healed Erosive Esophagitis Completed NCT01459367 Phase 3
47 A Multi-center, Randomized, Double-blind Phase III Clinical Trial to Assess and Compare to the Efficacy and Safety of Lafutidine, Famotidine and Omeprazole-referenced in Korean Erosive Esophagitis Patients Completed NCT01499368 Phase 3
48 Open-Label Extension Study of Reslizumab in Pediatric Subjects With Eosinophilic Esophagitis Completed NCT00635089 Phase 3
49 Double-blind Comparative Study of E3810 Tablets (10 or 20 mg b.i.d.) to Evaluate Efficacy and Safety in Patients With Refractory Reflux Esophagitis Completed NCT00770913 Phase 2, Phase 3
50 Long-Term Safety Study of TAK-438 in the Maintenance Treatment of Healed Erosive Esophagitis Completed NCT01452776 Phase 3

Search NIH Clinical Center for Esophagitis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: esophagitis

Genetic Tests for Esophagitis

Genetic tests related to Esophagitis:

id Genetic test Affiliating Genes
1 Esophagitis 29

Anatomical Context for Esophagitis

MalaCards organs/tissues related to Esophagitis:

39
Lymph Node, Lung, Endothelial, Liver, Colon, Testes, T Cells

Publications for Esophagitis

Articles related to Esophagitis:

(show top 50) (show all 8598)
id Title Authors Year
1
Diagnostic Value of Autoantibodies against Ezrin in Esophageal Squamous Cell Carcinoma. ( 28298808 )
2017
2
Partition-Defective 3 (PARD3) Regulates Proliferation, Apoptosis, Migration, and Invasion in Esophageal Squamous Cell Carcinoma Cells. ( 28526815 )
2017
3
Enhanced cancer stem cell properties of a mitotically quiescent subpopulation of p75NTR-positive cells in esophageal squamous cell carcinoma. ( 28534989 )
2017
4
Esophageal Cancer Diagnosed by Thyroid Scintigraphy. ( 28525453 )
2017
5
Comparative evaluation of target volumes defined by deformable and rigid registration of diagnostic PET/CT to planning CT in primary esophageal cancer. ( 28072693 )
2017
6
Association between ALDH2 Glu487Lys polymorphism and the risk of esophageal cancer. ( 28422823 )
2017
7
Brain Oxygenation During Thoracoscopic Repair of Long Gap Esophageal Atresia. ( 28058473 )
2017
8
Leukocytosis and neutrophilia predict outcome in locally advanced esophageal cancer treated with definitive chemoradiation. ( 28086222 )
2017
9
Effect of SATB1 silencing on the proliferation, invasion and apoptosis of TE-1 esophageal cancer cells. ( 28521398 )
2017
10
Eosinophilic Esophagitis vs Proton Pump Inhibitor-Responsive Esophageal Eosinophilia: Transcriptome Analysis. ( 28063872 )
2017
11
Intramural esophageal bronchogenic cyst mimicking achalasia in a toddler. ( 27822780 )
2017
12
Future Directions in Improving Outcomes for Patients with Gastric and Esophageal Cancer. ( 28501093 )
2017
13
Dumping syndrome after esophageal, gastric or bariatric surgery: pathophysiology, diagnosis, and management. ( 27749997 )
2017
14
Azidothymidine inhibits cell growth and telomerase activity and induces DNA damage in human esophageal cancer. ( 28487971 )
2017
15
Lymphocytic esophagitis: A rare finding in adult patients with dysphagia and food impaction. ( 28089355 )
2017
16
Recent advances in intensity modulated radiotherapy and proton therapy for esophageal cancer. ( 28503964 )
2017
17
A ligand-based and enediyne-energized bispecific fusion protein targeting epidermal growth factor receptor and insulin-like growth factor-1 receptor shows potent antitumor efficacy against esophageal cancer. ( 28498434 )
2017
18
Pseudogene PHBP1 promotes esophageal squamous cell carcinoma proliferation by increasing its cognate gene PHB expression. ( 28404970 )
2017
19
Protective Effect of Dietary Calcium Intake on Esophageal Cancer Risk: A Meta-Analysis of Observational Studies. ( 28524093 )
2017
20
Update on dietary therapy for eosinophilic esophagitis in children and adults. ( 27998193 )
2017
21
Thoracoscopic surgery for esophageal atresia. ( 28064362 )
2017
22
Influence of XRCC4 expression in esophageal cancer cellsA on the response to radiotherapy. ( 27338590 )
2017
23
Impact of Radiofrequency Ablation Treatment of Barrett's Esophagus on Esophageal Adenocarcinoma: A Comparative Modeling Analysis. ( 28089850 )
2017
24
Loss of PAR-3 protein expression is associated with invasion, lymph node metastasis, and poor survival in esophageal squamous cell carcinoma. ( 28188749 )
2017
25
RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer. ( 28533408 )
2017
26
Erratum: Effects of food insecurity on the women esophageal cancer in the Zanjan Province. ( 28508854 )
2017
27
LUGOL'S IODINE CHROMOENDOSCOPY VERSUS NARROW BAND IMAGE ENHANCED ENDOSCOPY FOR THE DETECTION OF ESOPHAGEAL CANCER IN PATIENTS WITH STENOSIS SECONDARY TO CAUSTIC/CORROSIVE AGENT INGESTION. ( 28492712 )
2017
28
Impaired bolus clearance in combined high-resolution esophageal manometry and impedance measurement helps to differentiate between esophagogastric junction outflow obstruction and achalasia. ( 28068730 )
2017
29
Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development. ( 28035351 )
2017
30
Knockdown of Ubiquitin-Specific Protease 14 (USP14) Inhibits the Proliferation and Tumorigenesis in Esophageal Squamous Cell Carcinoma Cells. ( 27629392 )
2017
31
Early adulthood body mass index, cumulative smoking, and esophageal adenocarcinoma survival. ( 28088657 )
2017
32
Noninvasive assessment of portal hypertension and detection of esophageal varices in cirrhosis: state-of-the-art. ( 28079668 )
2017
33
MiR-498 in esophageal squamous cell carcinoma: clinicopathological impacts and functional interactions. ( 28188753 )
2017
34
Folate intake, serum folate levels and esophageal cancer risk: an overall and dose-response meta-analysis. ( 28060731 )
2017
35
The effects of air pollution on mortality and clinicopathological features of esophageal cancer. ( 28489588 )
2017
36
The expression and significance of HOX transcript antisense RNA and epithelial-mesenchymal transition-related factors in esophageal squamous cell carcinoma. ( 28260072 )
2017
37
Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer. ( 28060765 )
2017
38
The Relationship of the Post-reflux Swallow-induced Peristaltic Wave Index and Esophageal Baseline Impedance with Gastroesophageal Reflux Disease Symptoms. ( 28044052 )
2017
39
miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2. ( 28277193 )
2017
40
Postoperative fluid overload is a risk factor for adverse surgical outcome in patients undergoing esophagectomy for esophageal cancer: a retrospective study in 335 patients. ( 28086855 )
2017
41
Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma. ( 27026568 )
2017
42
NFAT1 promotes cell motility through MMP-3 in esophageal squamous cell carcinoma. ( 28024290 )
2017
43
Special AT-rich sequence binding protein 1 promotes tumor growth and metastasis of esophageal squamous cell carcinoma. ( 28345457 )
2017
44
Esophageal Cancer. ( 28075104 )
2017
45
Expression profiles of cancer stem cell markers: CD133, CD44, Musashi-1 and EpCAM in the cardiac mucosa-Barrett's esophagus-early esophageal adenocarcinoma-advanced esophageal adenocarcinoma sequence. ( 28216140 )
2017
46
Risk Factors for Anastomotic Strictures after Esophageal Atresia Repair: Prophylactic Proton Pump Inhibitors Do Not Reduce the Incidence of Strictures. ( 27769086 )
2017
47
New Variant of Esophageal Atresia. ( 28083495 )
2017
48
Peroral endoscopic myotomy for an achalasia patient with multiple esophageal diverticula. ( 27967203 )
2017
49
Transient Receptor Potential Melastatin 7 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma. ( 28314277 )
2017
50
Esophageal Atresia with or without Tracheoesophageal Fistula (EA/TEF): Association of Different EA/TEF Subtypes with Specific Co-occurring Congenital Anomalies and Implications for Diagnostic Workup. ( 28061520 )
2017

Variations for Esophagitis

Expression for Esophagitis

Search GEO for disease gene expression data for Esophagitis.

Pathways for Esophagitis

Pathways related to Esophagitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 CCL11 CXCL8 EGFR IL13 IL1B IL5
2
Show member pathways
13.87 CCL11 CCL26 CCR3 CXCL8 EGFR IL13
3
Show member pathways
13.58 CCL11 CCL26 CXCL8 EGFR IL13 IL1B
4
Show member pathways
13.5 CCL11 CCL26 CCR3 CXCL8 EGFR IL13
5
Show member pathways
13.38 CCL11 CCL26 CCR3 CXCL8 EGFR IL13
6
Show member pathways
13.35 CCL11 CXCL8 EGFR IL13 IL1B IL5
7
Show member pathways
13.32 CCL11 CCL26 CCR3 CXCL8 EGFR IL13
8
Show member pathways
13.04 CXCL8 EGFR IL1B IL6 PTGS2 TNF
9
Show member pathways
12.97 CXCL8 IL1B IL6 STAT6 TNF TP53
10
Show member pathways
12.91 CCL11 CXCL8 IL13 IL1B IL5 IL6
11
Show member pathways
12.86 CXCL8 IL13 IL1B IL6 TNF TP53
12 12.72 CXCL8 EGFR IL6 PTGS2 TP53
13
Show member pathways
12.68 IL13 IL1B IL5 IL6 STAT6 TNF
14
Show member pathways
12.67 EGFR IL1B IL6 STAT6 TNF TP53
15
Show member pathways
12.52 EGFR IL13 IL1B IL5 TP53
16
Show member pathways
12.45 IL1B IL5 IL6 TNF
17
Show member pathways
12.41 IL1B IL6 PTGS2 SOD2 TNF TP53
18
Show member pathways
12.38 CCL11 CCL26 CCR3 CXCL8
19
Show member pathways
12.34 CXCL8 IL1B IL6 PTGS2 TNF TP53
20
Show member pathways
12.34 CCL11 CXCL8 IL13 IL1B IL5 IL6
21
Show member pathways
12.31 IL13 IL5 IL6 STAT6 TSLP
22
Show member pathways
12.27 CCL11 CXCL8 IL1B IL6 TNF
23 12.27 EGFR IL6 PTGS2 TNF TP53
24 12.26 CXCL8 IL13 IL1B IL6 TNF
25
Show member pathways
12.2 CXCL8 IL13 IL1B IL5 IL6 TNF
26 12.13 CXCL8 EGFR TNF TP53
27
Show member pathways
12.1 CCL11 CCL26 CCR3 CXCL8
28
Show member pathways
12.1 EGFR IL13 IL1B IL5 TP53
29 12.07 CCR3 IL5 IL6 TNF
30 12.06 CXCL8 EGFR IL1B IL6 PTGS2 TNF
31 12.03 IL1B IL6 PTGS2 TNF
32 12.02 CXCL8 IL1B IL6 TP53
33 11.99 CXCL8 IL1B IL6 TNF
34 11.98 IL1B IL5 IL6 TNF
35 11.97 CXCL8 IL1B IL6 TNF
36 11.96 CXCL8 IL1B PTGS2 TNF
37 11.93 CXCL8 IL1B IL6 TNF
38 11.9 CXCL8 IL13 IL5 IL6 TP53
39 11.88 IL13 IL1B IL5 TNF TSLP
40
Show member pathways
11.86 CXCL8 IL5 PTGS2 TNF
41 11.85 CXCL8 IL1B IL6
42 11.85 CXCL8 IL1B IL6 TNF
43 11.8 IL1B IL6 TNF
44 11.78 CXCL8 EGFR TP53
45 11.77 CCL11 CCL26 IL5 STAT6
46 11.76 IL5 IL6 TNF
47 11.73 EGFR IL6 STAT6
48
Show member pathways
11.73 CXCL8 IL1B IL6 PTGS2 TNF
49 11.72 CXCL8 EGFR IL6
50 11.68 CXCL8 IL1B IL6 TNF

GO Terms for Esophagitis

Cellular components related to Esophagitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CCL11 CCL26 CXCL8 EGFR IL13 IL1B
2 extracellular space GO:0005615 9.32 CCL11 CCL26 CXCL8 EGFR IL13 IL1B

Biological processes related to Esophagitis according to GeneCards Suite gene sharing:

(show all 48)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.99 CXCL8 IL1B IL6 PTGS2 SOD2 TP53
2 positive regulation of cell migration GO:0030335 9.94 CCL11 CCL26 EGFR SOD2
3 chemotaxis GO:0006935 9.94 CCL11 CCL26 CCR3 CXCL8
4 regulation of cell proliferation GO:0042127 9.93 EGFR IL6 PTGS2 STAT6 TNF
5 cytokine-mediated signaling pathway GO:0019221 9.92 IL1B IL5 IL6 STAT6
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.87 IL5 IL6 TP53
7 cellular response to tumor necrosis factor GO:0071356 9.87 CCL11 CCL26 CXCL8 IL6
8 movement of cell or subcellular component GO:0006928 9.86 CXCL8 IL13 PTGS2
9 positive regulation of protein kinase B signaling GO:0051897 9.86 EGFR IL6 TNF
10 positive regulation of angiogenesis GO:0045766 9.86 CCL11 CCR3 CXCL8 IL1B
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 IL6 PTGS2 TNF
12 response to glucocorticoid GO:0051384 9.85 IL6 PTGS2 TNF
13 positive regulation of endothelial cell proliferation GO:0001938 9.85 CCL11 CCL26 CCR3
14 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.85 IL1B IL5 IL6 TNF
15 response to lipopolysaccharide GO:0032496 9.85 IL13 IL1B IL6 PTGS2 SOD2
16 cellular response to drug GO:0035690 9.84 EGFR IL1B TP53
17 response to cytokine GO:0034097 9.83 IL6 PTGS2 STAT6
18 negative regulation of fat cell differentiation GO:0045599 9.81 IL6 SOD2 TNF
19 immune response GO:0006955 9.81 CCL11 CCL26 CXCL8 HRH2 IL13 IL1B
20 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 TNF
21 cellular response to mechanical stimulus GO:0071260 9.8 EGFR IL13 IL1B PTGS2
22 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.8 CCL11 CCL26 EGFR IL6 TNF
23 monocyte chemotaxis GO:0002548 9.78 CCL11 CCL26 IL6
24 cellular response to interleukin-1 GO:0071347 9.78 CCL11 CCL26 CXCL8 IL6
25 response to radiation GO:0009314 9.77 CCL11 PTGS2 SOD2
26 positive regulation of vasoconstriction GO:0045907 9.75 EGFR HRH2 PTGS2
27 chemokine-mediated signaling pathway GO:0070098 9.73 CCL11 CCL26 CCR3 CXCL8
28 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL1B TNF
30 positive regulation of NF-kappaB import into nucleus GO:0042346 9.7 IL1B PTGS2 TNF
31 positive regulation of podosome assembly GO:0071803 9.69 IL5 TNF
32 positive regulation of immunoglobulin secretion GO:0051024 9.69 IL5 IL6
33 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
34 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
35 neutrophil chemotaxis GO:0030593 9.67 CCL11 CCL26 CXCL8 IL1B
36 response to manganese ion GO:0010042 9.66 PTGS2 SOD2
37 hydrogen peroxide metabolic process GO:0042743 9.66 EGFR SOD2
38 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
39 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.65 IL6 TNF
40 positive regulation of smooth muscle cell proliferation GO:0048661 9.65 EGFR IL13 IL6 PTGS2 TNF
41 sequestering of triglyceride GO:0030730 9.62 IL1B TNF
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IL1B TNF
43 positive regulation of fever generation GO:0031622 9.5 IL1B PTGS2 TNF
44 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 EGFR IL1B IL6 PTGS2 SOD2 TNF
45 inflammatory response GO:0006954 9.32 CCL11 CCL26 CCR3 CXCL8 IL13 IL1B
46 signal transduction GO:0007165 10.26 CCL11 CCL26 CCR3 CXCL8 EGFR HRH2
47 positive regulation of transcription, DNA-templated GO:0045893 10.08 EGFR IL1B IL5 IL6 TNF TP53
48 MAPK cascade GO:0000165 10 EGFR IL1B IL5 TNF

Molecular functions related to Esophagitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.55 CYP2C19 EGFR PTGS2 SOD2 TP53
2 protein phosphatase binding GO:0019903 9.5 EGFR STAT6 TP53
3 chemokine activity GO:0008009 9.43 CCL11 CCL26 CXCL8
4 cytokine activity GO:0005125 9.28 CCL11 CCL26 CXCL8 IL13 IL1B IL5
5 CCR3 chemokine receptor binding GO:0031728 8.96 CCL11 CCL26

Sources for Esophagitis

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10 dbSNP
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16 ExPASy
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