MCID: ESP024
MIFTS: 60

Esophagitis malady

Summaries for Esophagitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Esophagitis (or oesophagitis) is inflammation of the esophagus. It may be acute or chronic. Acute... more...

MalaCards: Esophagitis, also known as acute esophagitis, is related to squamous cell carcinoma and esophageal cancer. An important gene associated with Esophagitis is DEC1 (deleted in esophageal cancer 1), and among its related pathways are Signaling events mediated by the Hedgehog family and Glypican 3 network. The drugs omeprazole and sucralfate and the compound cyclopamine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, lung and endothelial, and related mouse phenotypes are digestive/alimentary and integument.

Aliases & Classifications for Esophagitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 34MeSH, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

esophagitis 8 10 44 60
acute esophagitis 8 60


External Ids:

Disease Ontology8 DOID:11963
ICD9CM27 530.1, 530.10
MeSH34 D004941
NCIt39 C9224

Related Diseases for Esophagitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Esophagitis family:

Bacterial Esophagitis Viral Esophagitis

Diseases related to Esophagitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 694)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.9FHIT, CTAG1B, CTSB, KDM4C, KRT4, PTCH1
2esophageal cancer31.9DLEC1, C2orf40, ATP4A, FHIT
3adenocarcinoma31.6FHIT, CTAG1B, CTSB, KRT4, PTCH1
4lung cancer30.7DLEC1, FHIT
5stomach cancer30.2FHIT, CTAG1B, CTSB, PTCH1
6breast cancer30.0FHIT, CTAG1B, CTSB, DLEC1, PTCH1
7transitional cell carcinoma29.9FHIT, CTAG1B, CTSB, PTCH1
8esophageal squamous cell carcinoma29.8DEC1, LZTS1
9prostate cancer29.7CTAG1B, CTSB, DLEC1, TMPRSS11A
10pallister-hall syndrome29.7SHH
11bladder carcinoma29.5LZTS1, FHIT, CTAG1B, PTCH1
12esophageal atresia11.1
13eosinophilic esophagitis11.1
14esophageal disease11.0
15barrett's esophagus10.9
16barrett's adenocarcinoma10.8
17achalasia10.8
18esophagus adenocarcinoma10.8
19esophageal candidiasis10.7
20peptic esophagitis10.7
21candidiasis10.7
22gastroesophageal reflux disease10.7
23hiatus hernia10.7
24esophageal tuberculosis10.6
25gastric adenocarcinoma10.6
26tuberculosis10.6
27duodenitis10.5
28esophageal varix10.5
29lymph node cancer10.5
30eosinophilia10.4
31gastric squamous cell carcinoma10.4
32leiomyomatosis10.4
33epidermolysis bullosa10.4
34thoracic cancer10.4
35cardia cancer10.4
36leiomyoma10.4
37mediastinitis10.4
38obesity10.4
39hypertension10.4
40cervicitis10.4
41gastritis10.4
42peptic ulcer10.4
43small cell carcinoma10.3
44liver cirrhosis10.3
45papilloma10.3
46portal hypertension10.3
47esophageal atresia/tracheoesophageal fistula10.3
48tylosis with esophageal cancer10.3
49vacterl association10.3
50duodenal ulcer10.3

Graphical network of the top 20 diseases related to Esophagitis:



Diseases related to esophagitis

Clinical Features for Esophagitis

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Drugs & Therapeutics for Esophagitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Esophagitis

Drug clinical trials:

Search ClinicalTrials for Esophagitis

Search NIH Clinical Center for Esophagitis

Search CenterWatch for Esophagitis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Esophagitis

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Anatomical Context for Esophagitis

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32MalaCards
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MalaCards organs/tissues related to Esophagitis:

32
Lymph node, Lung, Endothelial, Liver, Colon, Testes, T cells, Smooth muscle, Breast, Bone, Spleen, Brain, Heart, Bone marrow, Thyroid, Testis, Skin, Pituitary, Trachea, Prostate, Tongue, B cells, Small intestine, Myeloid, Pancreas, Kidney, Whole blood, Monocytes, Nk cells, Skeletal muscle

Animal Models for Esophagitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Esophagitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538111.7PTCH1, KRT4, SHH, ATP4A, CTSB, FHIT
2MP:001077111.6PTCH1, FHIT, CTSB, SHH, CLDN6, KDM4C

Publications for Esophagitis

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50PubMed
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Articles related to Esophagitis:

(show top 50)    (show all 6937)
idTitleAuthorsYear
1
Continuing increased risk of oral/esophageal cancer after allogeneic hematopoietic stem cell transplantation in adults in association with chronic graft-versus-host disease. (24399081)
2014
2
Relevance of ineffective esophageal motility to secondary peristalsis in patients with gastroesophageal reflux disease. (23981079)
2014
3
Development and Characterization of a Surgical Mouse Model of Reflux Esophagitis and Barrett's Esophagus. (24190247)
2013
4
Development and validation of a registry-based definition of eosinophilic esophagitis in Denmark. (23382628)
2013
5
Personalizing therapy for esophageal cancer patients. (24199697)
2013
6
Theory of mind deficits in patients with esophageal cancer combined with depression. (23704831)
2013
7
Altered expression of endogenous soluble vascular endothelial growth factor receptor-2 is involved in the progression of esophageal squamous cell carcinoma. (23392734)
2013
8
Successful esophageal bypass surgery in a patient with a large tracheoesophageal fistula following endotracheal stenting and chemoradiotherapy for advanced esophageal cancer: case report. (23482402)
2013
9
Kinetics of transient hiatus hernia during transient lower esophageal sphincter relaxations and swallows in healthy subjects. (22680279)
2012
10
A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. (21551004)
2012
11
Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma. (22860235)
2012
12
Meta-analysis of Chinese medicines for prevention and treatment of radiation esophagitis. (22876434)
2012
13
Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination. (21413013)
2012
14
Current knowledge on esophageal atresia. (22851858)
2012
15
Analysis of XPD genetic polymorphisms of esophageal squamous cell carcinoma in a population of Yili Prefecture, in Xinjiang, China. (21553048)
2012
16
What is the optimal management of dysphagia in metastatic esophageal cancer? (22514498)
2012
17
Genomic alterations with impact on survival in esophageal squamous cell carcinoma identified by array comparative genomic hybridization. (21484929)
2011
18
miR-29c induces cell cycle arrest in esophageal squamous cell carcinoma by modulating cyclin E expression. (21551130)
2011
19
Acquired Tracheoesophageal Fistula through Esophageal Diverticulum in Patient Who Had a Prolonged Tracheostomy Tube - A Case Report -. (22506156)
2011
20
Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice. (20381491)
2010
21
Correlation between clinicopathological factors and enzymatic activity of orotate phosphoribosyl transferase (OPRT), dihydropyrimidine dehydrogenase (DPD) in esophageal cancer]. (20647710)
2010
22
The prognostic value of clinical and pathologic factors in esophageal adenocarcinoma: a mayo cohort of 796 patients with extended follow-up after surgical resection. (21123634)
2010
23
Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression. (18989634)
2009
24
Effect of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal adenocarcinoma formation in a rat surgical model. (19058177)
2009
25
Expression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma. (19698122)
2009
26
Eosinophilic esophagitis with severe GERD. (19174817)
2009
27
Use of transanastomotic feeding tubes during esophageal atresia repair. (19433166)
2009
28
Altered expression of CD44 and DKK1 in the progression of Barrett's esophagus to esophageal adenocarcinoma. (19396460)
2009
29
The expression of type IV collagen alpha6 chain is related to the prognosis in patients with esophageal squamous cell carcinoma. (17955302)
2008
30
Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression. (18199717)
2008
31
Reflections on current food allergy controversies: specific IgE test application, patch testing, eosinophilic esophagitis, and probiotics. (18926052)
2008
32
Chromogranin A-positive tumor cells in human esophageal squamous cell carcinomas. (18158567)
2007
33
IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms. (17457048)
2007
34
Correlation of XPC Ala499Val and Lys939Gln polymorphisms to risks of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (16965652)
2006
35
Gastric fluid level after overnight fast: Test to diagnose gastric outlet obstruction in corrosive esophageal stricture. (17090859)
2006
36
Factors predicting in-hospital mortality in patients with cirrhosis hospitalized with gastro-esophageal variceal hemorrhage. (17090841)
2006
37
Expression of p53 in esophageal carcinoma with multiple areas unstained by iodine. (16201092)
2005
38
Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma. (15205355)
2004
39
Coexpression of heparanase, basic fibroblast growth factor and vascular endothelial growth factor in human esophageal carcinomas. (15260846)
2004
40
Comments on "Investigation of intra-abdominal esophagus and hiatus in fetal rats with esophageal atresia and tracheo-esophageal fistula". (15243772)
2004
41
Terlipressin for acute esophageal variceal hemorrhage. (11279753)
2001
42
Clonal expansion and loss of heterozygosity at chromosomes 9p and 17p in premalignant esophageal (Barrett's) tissue. (10601379)
1999
43
Left-sided esophageal indentation in right aortic arch with aberrant left subclavian artery. (8153342)
1994
44
Hiatus hernia and reflux esophagitis. (7904609)
1994
45
Sclerodermalike esophageal disease in children breast-fed by mothers with silicone breast implants. (8277548)
1994
46
Increased plasma endothelin-1 levels in patients with cirrhosis and esophageal varices. (8228084)
1993
47
The association of esophageal hiatus hernia with Mallory-Weiss syndrome. (2744343)
1989
48
Adult esophageal candidiasis: a radiographic spectrum. (3448636)
1987
49
Esophageal duplication cyst containing a foreign body. (3971270)
1985
50
Esophageal duplication cyst. Case report. (7416128)
1980

Genetic Variations for Esophagitis

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Expression for genes affiliated with Esophagitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophagitis

Search GEO for disease gene expression data for Esophagitis.

Pathways for genes affiliated with Esophagitis

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37NCBI BioSystems Database
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Pathways related to Esophagitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9PTCH1, SHH
210.9PTCH1, SHH

Compounds for genes affiliated with Esophagitis

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44Novoseek, 59Tocris Bioscience
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Compounds related to Esophagitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclopamine44 5911.9PTCH1, SHH

GO Terms for genes affiliated with Esophagitis

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16Gene Ontology
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Biological processes related to Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somite developmentGO:06105310.9PTCH1, SHH
2spinal cord motor neuron differentiationGO:02152210.9PTCH1, SHH
3renal system developmentGO:07200110.8PTCH1, SHH
4negative regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243510.6SHH, FHIT

Molecular functions related to Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1patched bindingGO:00511310.9PTCH1, SHH

Products for genes affiliated with Esophagitis

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  • Antibodies
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  • Antibodies

Sources for Esophagitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet