Esophagitis malady

Wikipedia: Esophagitis (or oesophagitis) is inflammation of the esophagus. It may be acute or chronic. Acute...⁴⁴ more...

MalaCards: Esophagitis, also known as acute esophagitis, is related to carcinoma and adenocarcinoma. An important gene associated with Esophagitis is DEC1 (deleted in esophageal cancer 1), and among its related pathways are Pathways in cancer and Antioxidant Action of Vitamin-C. The drugs sucralfate and lansoprazole and the compounds atp and progesterone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are homeostasis/metabolism and digestive/alimentary.

Aliases & Descriptions:

esophagitis 6 8 32 43 acute esophagitis 6 43

acute esophagitis (disorder) 6

Diseases related to esophagitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 941)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	290.4	ZNF673, ZNF410, ZNF135, ZNF639, ZNF207, PIK3CB
2	adenocarcinoma	216.2	ZNF24, ZNF624, PIK3CB, PIK3CA, PIK3C2A, PIK3CG
3	prostatitis	206.7	ZNF673, PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIN1
4	leukemia	195.3	ZNF673, PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIN1
5	pancreatitis	192.6	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIN1, PIM1
6	esophageal squamous cell carcinoma	190.5	ZNF673, ZNF410, ZNF639, PIK3CA, PIN1, PIK3C3
7	gastric cancer	183.5	PIK3CB, PIK3CA, PIK3CG, PIN1, PIM1, LRP1B
8	hepatocellular carcinoma	174.3	PIK3CB, PIK3CA, PIK3CG, PIN1, KLF6, NCAM1
9	melanoma	167.5	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIM1, KLF5
10	esophageal cancer	164.7	ZNF135, PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5
11	cervicitis	160.0	PIK3CA, PIK3CG, PIN1, PDCD1LG2, PDCD4, PDE4A
12	colon cancer	155.5	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, KLF6
13	hypoxia	133.8	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIM1, KLF5
14	sarcoma	123.9	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIK3C3, NCAM1
15	ovarian carcinoma	123.1	PIK3CA, PIK3CG, NCOA3, PDCD4, PDCD5, RECK
16	cervical cancer	121.4	PIK3CA, PIK3CG, PIN1, RELA, SFN, SFRP1
17	fibrosis	118.5	PIK3CA, PIK3CG, PIN1, KLF6, NCOA3, PDE4A
18	lung carcinoma	116.7	PIK3CA, PIK3CG, LRP1B, KLF6, NCAM1, RECK
19	oral squamous cell carcinoma	112.8	PIK3CA, PIK3C2A, PIN1, PIM1, LRP1B, PDCD1LG2
20	nasopharyngitis	109.7	PIK3CA, PIK3CG, KLF5, KLF6, NCOA3, RECK
21	neuronitis	108.6	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIN1, PIK3C3
22	thyroiditis	103.6	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIN1, LRP1B
23	esophageal carcinoma	103.1	ZNF207, RELN, KIT, VSIG1, PCNA, RB1
24	laryngitis	98.1	PIK3CA, PIM1, PDCD4, RELA, SFN, PCNA
25	hypertension	98.1	PIK3CB, PIK3C2A, PIK3CG, PIM1, KLF5, KLF6
26	cervical carcinoma	92.4	PIK3CA, PIK3CG, PDCD1LG2, RECK, RELA, REV1
27	breast carcinoma	91.2	PIK3CA, PIK3CG, NCOA3, RECK, WASL, KIT
28	obesity	90.1	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, NCOA3, RECK
29	retinoblastoma	86.9	PIK3CB, PIK3CA, PIK3CG, KLF6, NCAM1, RECK
30	meningioma	86.5	PIK3CG, WDHD1, NCAM1, NCOA3, RET, REV1
31	adenoma	83.2	ZNF410, PIK3CA, LRMP, KLF4, NCAM1, NCOA3
32	neuroblastoma	80.5	PIK3CB, PIK3CA, PIK3CG, PIN1, KLF4, KLF6
33	arthritis	80.5	PIK3CG, PIN1, KLF5, PDCD1LG2, PDCD5, PDE4A
34	polyposis	74.5	PIK3CG, PIN1, KLF4, KLF6, RELA, RET
35	gingivitis	74.3	PIK3CG, CNR1, PCNA, SELE, SELL, SETD2
36	gonococcal synovitis	74.3	PIK3CB, PIK3CA, PIK3CG, KLF4, NCAM1, PDE4A
37	rheumatoid arthritis	74.2	PIK3CG, PIN1, KLF5, PDCD1LG2, PDCD5, PDE4A
38	myeloid leukemia	73.2	ZNF673, PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIN1
39	liver cancer	72.1	PIK3CG, PIN1, REG1A, RELN, SFRP2, RB1
40	barrett's esophagus	71.7	PIK3CB, PIK3CA, REG1A, SFRP1, SFRP2, SFRP4
41	bladder carcinoma	69.6	PIK3CA, PIK3CG, SFN, PCNA, RB1, RBL2
42	alzheimer's disease	69.4	PIK3CB, PIK3CA, PIK3CG, PIN1, PIK3C3, LRP1B
43	kaposi's sarcoma	68.1	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIK3C3, PDE4A
44	colon carcinoma	67.5	PIK3CB, PIK3CA, PIK3CG, KLF4, KLF5, NCAM1
45	myeloma	66.0	PIK3CA, PIK3CG, NCAM1, PDCD5, PDE4A, RECK
46	leiomyoma	65.3	KIT, SFRP1, PCNA, RBP1, SERPINB3, SELENBP1
47	duodenitis	65.3	PIK3CG, KIT, KITLG, PCNA, GCG, VIP
48	ataxia	64.9	ZNF639, PIK3CA, PIK3CG, PIN1, RERE, SGCG
49	cholesterol	64.2	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIK3C3, LRP1B
50	cerebritis	63.2	PIK3C2A, PIK3CG, KLF4, KLF6, NCAM1, PDE4A

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 esomeprazole, esomeprazole magnesium, esomeprazole sodium, lansoprazole, omeprazole, omeprazole magnesium, pantoprazole, pantoprazole sodium, sucralfate

MalaCards organs/tissues related to esophagitis:

²²

MGI Mouse Phenotypes related to esophagitis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIK3C3, KLF4
2	digestive/alimentary phenotype	MP:0005381	INF	KLF4, KLF5, NCOA3, RELN, RET, WASL
3	behavior/neurological phenotype	MP:0005386	INF	ZNF24, PIK3CA, PIK3C3, KLF4, NCAM1, NCOA3
4	normal phenotype	MP:0002873	INF	PIK3C3, LRP1B, KLF4, KLF5, RELA, RERE
5	growth/size phenotype	MP:0005378	INF	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIN1, PIK3C3
6	nervous system phenotype	MP:0003631	INF	ZNF24, PDE4A, RECK, REG1B, RELA, RELN
7	mortality/aging	MP:0010768	INF	ZNF24, PIK3CB, PIK3CA, PIK3C2A, PIK3C3, KLF4
8	cardiovascular system phenotype	MP:0005385	67.3	PIK3CB, PIK3CA, PIK3CG, PIK3C3, KLF5, KLF6
9	tumorigenesis	MP:0002006	53.7	PIK3CB, PIK3CA, KLF4, NCOA3, PDCD1LG2, PDCD4
10	hematopoietic system phenotype	MP:0005397	49.3	PIM1, KLF6, PDCD1LG2, REV1, REV3L, KIT
11	vision/eye phenotype	MP:0005391	43.3	PIK3CA, PIN1, NCAM1, RELA, RELN, RERE
12	skeleton phenotype	MP:0005390	42.6	PIK3CG, RECK, RELA, SGCG, CNR1, KIT
13	no phenotypic analysis	MP:0003012	30.9	PDCD1LG2, RET, CNR1, KIF22, SFRP1, SFRP2
14	limbs/digits/tail phenotype	MP:0005371	29.8	RECK, RELA, RET, KIT, KITLG, SFN
15	adipose tissue phenotype	MP:0005375	26.1	PIK3CA, PIK3C2A, NCOA3, CNR1, SFRP1, BUB1B
16	craniofacial phenotype	MP:0005382	24.9	KLF4, NCOA3, RERE, REV3L, KIT, KITLG
17	hearing/vestibular/ear phenotype	MP:0005377	24.9	NCOA3, KIT, KITLG, SFN, RB1, RBP1
18	liver/biliary system phenotype	MP:0005370	24.1	PIK3C3, KLF6, NCOA3, RECK, REG1B, KIT
19	pigmentation phenotype	MP:0001186	20.2	KIT, KITLG, RB1, RBP1, SERPINC1, BRAF
20	other phenotype	MP:0005395	17.5	RECK, CNR1, SERPINH1, RARA, RARB, CLU
21	respiratory system phenotype	MP:0005388	17.5	KLF5, RET, SFRP4, SFTPD, SELL, BRCA1
22	integument phenotype	MP:0010771	INF	PIK3CG, PIN1, KLF4, KLF6, NCOA3, RECK
23	immune system phenotype	MP:0005387	INF	PIK3C3, KLF5, NCOA3, PDCD4, PDE4A, REV1
24	reproductive system phenotype	MP:0005389	INF	PIK3CA, KLF4, KLF6, NCOA3, PDCD4, REG1A
25	renal/urinary system phenotype	MP:0005367	INF	NCOA3, PDCD4, RET, KIT, KISS1, KISS1R
26	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3CG, PIK3C3, KLF5, NCOA3, RELA
27	embryogenesis phenotype	MP:0005380	INF	ZNF24, PIK3CB, PIK3CA, PIK3C3, KLF5, KLF6
28	cellular phenotype	MP:0005384	INF	ZNF24, PIK3CB, PIK3CA, PIK3CG, PIN1, PIK3C3
29	endocrine/exocrine gland phenotype	MP:0005379	INF	KLF4, KLF5, PDCD4, REG1A, RET, WASL

Articles related to esophagitis:

(show top 50)    (show all 2310)

id	Title	Authors	Year	Affiliating Genes
1	Gene mutations and polymorphisms of TP53 and FHIT in chronic esophagitis and esophageal carcinoma. (21617227)	Silveira A.P.... Silva A.E.	2011	TP53, FHIT
2	DNA copy number profile discriminates between esophag eal adenocarcinoma and squamous cell carcinoma and represents an independent pr ognostic parameter in esophageal adenocarcinoma. (21757289)	Rumiato E.... Saggioro D.	2011	CDKN2A, CDKN2B
3	The effect of oral buspirone, pyridostigmine, and bet hanechol on esophageal function evaluated with combined multichannel esophageal impedance-manometry in healthy volunteers. (18987553)	Blonski W.... Castell D.O.	2009	ACHE
4	The presence of aberrant DNA methylation in noncancer ous esophageal mucosae in association with smoking history: a target for risk d iagnosis and prevention of esophageal cancers. (19472401)	Oka D.... Ushijima T.	2009	UCHL1, PKP1, CLDN6
5	Increased esophageal regulatory T cells and eosinophil characteristics in children with eosinophilic esophagitis and gastroesophageal reflux disease. (19429794)	Tantibhaedhyangkul U.... Davis C.M.	2009	CCL26
6	Expression of esophageal cancer related gene 4 (ECRG4 ), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effec t on the tumor growth in vitro and in vivo. (19521989)	Li L.W.... Lu S.H.	2009	DNMT1, C2orf40
7	Polymorphism Arg290Arg in esophageal-cancer-related gene 1 (ECRG1) is a prognostic factor for survival in esophageal cancer. (19052822)	Bachmann K.... Strate T.	2009	TMPRSS11A
8	Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression. (18989634)	Figueroa J.D.... Chow W.H.	2009	TP53
9	A comparative analysis by SAGE of gene expression profiles of esophageal adenocarcinoma and esophageal squamous cell carcinoma. (18219111)	van Baal J.W.... Krishnadath K.K.	2008	ANXA10
10	No association between hOGG1, XRCC1, and XPD polymorphisms and risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma: results from the factors influencing the Barrett's adenocarcinoma relationship case-control study. (18349297)	Ferguson H.R.... Hardie L.J.	2008	ERCC2, OGG1, XRCC1
11	Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone. (18628484)	Sims S.M.... Preiksaitis H.G.	2008	RHOA
12	Cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphisms and risk of reflux esophagitis, Barrett's esophagus, and esophageal adenocarcinoma. (18349295)	Ferguson H.R.... Hardie L.J.	2008	PTGS2, NOS2
13	Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma. (19137073)	Adams L.... Woodson K.	2008	CDKN2A, CLDN3, AHRR
14	Impact of gastro-esophageal reflux on mucin mRNA expression in the esophageal mucosa. (18452049)	van Roon A.H.... Hussey D.J.	2008	MUC3A
15	XIAP is highly expressed in esophageal cancer and its downregulation by RNAi sensitizes esophageal carcinoma cell lines to chemotherapeutics. (17611394)	Zhang S.... Zhang L.	2007	XIAP
16	Involvement of oxidative stress in experimentally induced reflux esophagitis and esophageal cancer. (17591057)	Inayama M.... Shiozaki H.	2007	PCNA
17	Alterations in manganese superoxide dismutase expression in the progression from reflux esophagitis to esophageal adenocarcinoma. (17473952)	Li Y.... Martin R.C.	2007	SOD2
18	Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells. (17570215)	Milano F.... Krishnadath K.K.	2007	BMP4
19	Chenodeoxycholic acid stimulates the progression of human esophageal cancer cells: A possible mechanism of angiogenesis in patients with esophageal cancer. (16557574)	Soma T.... Shimada Y.	2006	EGFR, VEGFA, PTGS2
20	Identification of a novel polymorphism Arg290Gln of esophageal cancer related gene 1 (ECRG1) and its related risk to esophageal squamous cell carcinoma. (16267096)	Li Y.... Lu S.-H.	2006	TMPRSS11A
21	Cytokine expression in normal and inflamed esophageal mucosa: a study into the pathogenesis of allergic eosinophilic esophagitis. (16385249)	Gupta S.K.... HogenEsch H.	2006	IL13, IL5, CCL26
22	The expression of p53, p16, cyclin D1 in esophageal squamous cell carcinoma and esophageal dysplasia (17060721)	Kim S.G.... Kim B.S.	2006	TP53, CCND1, CDKN2A
23	mRNA expression of inducible nitric oxide synthase, endothelial nitric oxide synthase and vascular endothelial growth factor in esophageal mucosa biopsy specimens from patients with reflux esophagitis. (16795973)	Inamori M.... Tominaga S.	2006	NOS3, NOS2
24	Inhibitory effects of esophageal cancer related gene 2 on proliferation of human esophageal cancer cell EC9706 (16324322)	Li M.N.... Lu S.H.	2005	SPINK7
25	Expression of CXC receptor 1 and 2 in esophageal mucosa of patients with reflux esophagitis. (15793866)	Isomoto H.... Kohno S.	2005	CXCR1, CXCR2
26	Expression of aldehyde dehydrogenase 2 in the normal esophageal epithelium and alcohol consumption in patients with esophageal cancer. (15970497)	Morita M.... Yasumoto K.	2005	ALDH2
27	Environmental exposure and p53 mutations in esophageal cancer patients in areas of low and high incidence of esophageal cancer in China. (16272802)	Sakaguchi S.... Nakajima T.	2005	TP53
28	Inhibitory effects of transfected Bcl-XL antisense oligodeoxynucleotide on proliferation of esophageal cancer cells and growth of human esophageal carcinoma in nude mice (16251044)	Zhang L.... Zhang Y.H.	2005	BCL2L1
29	The relationship between the esophageal tissue content of neurotensin and the presence or absence of esophageal inflammation. (14992433)	Dekel R.... Fass R.	2004	NTS
30	Evaluation of p53 mutations in premalignant esophageal lesions and esophageal adenocarcinoma using laser capture microdissection. (15257314)	Djalilvand A.... Kocher O.	2004	TP53
31	Short tandem repeat polymorphism in a novel esophageal cancer-related gene (ECRG2) implicates susceptibility to esophageal cancer in Chinese population. (14639608)	Yue C.M.... Lu S.H.	2004	SPINK7
32	Analysis of p53 mutational spectra of esophageal squamous cell carcinomas from Linzhou, comparison with esophageal and other cancers from other areas (12816712)	Wang L.D.... Zheng S.	2003	TP53
33	Expressions of PCNA, p53, p21(WAF-1) and cell proliferation in fetal esophageal epithelia: comparative study with adult esophageal lesions from subjects at high-incidence area for esophageal cancer in Henan, North China. (12854173)	Xing Y.... Wang L.D.	2003	PCNA
34	Expression of ECRG4, a novel esophageal cancer-related gene, downregulated by CpG island hypermethylation in human esophageal squamous cell carcinoma. (12800218)	Yue C.M.... Lu S.H.	2003	C2orf40
35	Elevated levels of chemokines in esophageal mucosa of patients with reflux esophagitis. (12650786)	Isomoto H.... Kohno S.	2003	CCL2, IL8
36	COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer. (14552327)	Piazuelo E.... Lanas A.	2003	PTGS2
37	Three isoforms of annexin I are preferentially expressed in normal esophageal epithelia but down-regulated in esophageal squamous cell carcinomas. (12242662)	Xia S.H.... Wang M.R.	2002	ANXA1
38	S100P expression in human esophageal epithelial cells: Human esophageal epithelial cells sequentially produce different S100 proteins in the process of differentiation. (11984793)	Sato N.... Hitomi J.	2002	S100A2, S100A12
39	Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy. (11121210)	Epperly M.W.... Koe G.	2001	SOD2
40	Esophageal stromal tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 17 cases and comparison with esophageal leiomyomas and leiomyosarcomas. (10680889)	Miettinen M.... Lasota J.	2000	KIT, DES
41	Cyclin D1 overexpression in esophageal dysplasia: a possible biomarker for carcinogenesis of esophageal squamous cell carcinoma. (10639568)	Shamma A.... Monden M.	2000	CCND1, CDKN1B, CDKN2A
42	Signal transduction pathways in esophageal and lower esophageal sphincter circular muscle. (9422618)	Biancani P.... Behar J.	1997	DYT10
43	Expression of PCNA and p53 in esophageal dysplasia and esophageal carcinoma. (9306559)	Murakami S.... Shimoda H.	1997	TP53, PCNA
44	Leukotrienes in acetylcholine-induced contraction of esophageal circular smooth muscle in experimental esophagitis. (9136833)	Kim N.... Biancani P.	1997	PLA2G6
45	p53 protein accumulation and gene mutations in multifocal esophageal precancerous lesions from symptom free subjects in a high incidence area for esophageal carcinoma in Henan, China. (8608498)	Wang L.D.... Yang C.S.	1996	TP53
46	Correlation studies on the alterations of multiple tumor suppressor genes in human esophageal cancer and in human and monkey esophageal epithelial cells treated with N-methyl-N-benzyl nitrosamine (7587888)	Li H.... Cui X.	1995	APC
47	Possible predictive markers of immunotherapy in esophageal cancer: retrospective analysis of a randomized study. The Cooperative Study Group for Esophageal Cancer in Japan. (7627722)	Ogoshi K.... Sugita M.	1995	SERPINA3
48	Multiple tumor suppressor genes in esophageal carcinoma induced in human fetus esophageal epithelium by NMBzA (7656818)	Li H.... Cui X.	1995	TP53, APC
49	Distinct muscarinic receptors, G proteins and phospho lipases in esophageal and lower esophageal sphincter circular muscle. (8263781)	Sohn U.D.... Biancani P.	1993	HSPG2, PLCG1
50	Overexpression of p53 protein in human spontaneous esophageal carcinoma and fetal esophageal carcinoma induced by N-methyl-N-benzylnitrosamine (NMBzA) (1396069)	Guo Y.J.	1992	TP53

Genes related to esophagitis according to GeneCards:

(show top 50)    (show all 1425)

id	Symbol	Description	Score	GeneCards Section Context
1	DEC1	deleted in esophageal cancer 1	11.1	Summaries, Publications, Aliases & Descriptions
2	DLEC1	deleted in lung and esophageal cancer 1	11.0	Transcripts, Publications, Aliases & Descriptions, Proteins (show all 5 sections) Orthologs
3	KRT4	keratin 4	11.0	Expressions, Summaries, Publications, Functions
4	C2orf40	chromosome 2 open reading frame 40	11.0	Publications, Aliases & Descriptions
5	RNF6	ring finger protein (C3H2C3 type) 6	11.0	Publications, Summaries
6	FHIT	fragile histidine triad	11.0	Publications, Summaries
7	CLDN6	claudin 6	11.0	Publications, Summaries
8	PTCH1	patched 1	11.0	Publications, Summaries
9	SHH	sonic hedgehog	11.0	Publications, Summaries
10	KDM4C	lysine (K)-specific demethylase 4C	11.0	Expressions, Publications, Summaries
11	DCC	deleted in colorectal carcinoma	11.0	Publications, Summaries
12	CTAG1B	cancer/testis antigen 1B	11.0	Publications, Aliases & Descriptions
13	C15orf48	chromosome 15 open reading frame 48	11.0	Publications, Expressions, Summaries
14	TMPRSS11A	transmembrane protease, serine 11A	11.0	Publications, Aliases & Descriptions
15	FZD7	frizzled family receptor 7	11.0	Publications, Expressions, Summaries
16	RPL15	ribosomal protein L15	11.0	Publications, Summaries
17	VSIG1	V-set and immunoglobulin domain containing 1	11.0	Expressions, Summaries
18	ATP4A	ATPase, H+/K+ exchanging, alpha polypeptide	11.0	Summaries
19	CTSB	cathepsin B	11.0	Publications, Summaries
20	EE	Esophagitis, eosinophilic	11.0	Aliases & Descriptions
21	EOE2	Esophagitis, eosinophilic, 2	11.0	Aliases & Descriptions
22	GAEC1	gene amplified in esophageal cancer 1	11.0	Publications, Aliases & Descriptions
23	LZTS1	leucine zipper, putative tumor suppressor 1	11.0	Publications, Aliases & Descriptions
24	CTHRC1	collagen triple helix repeat containing 1	11.0	Publications, Summaries
25	ASCC1	activating signal cointegrator 1 complex subunit 1	11.0	Publications, Summaries
26	LOC100421153	deleted in lung and esophageal cancer 1 pseudogene	11.0	Aliases & Descriptions
27	ZNF639	zinc finger protein 639	11.0	Publications, Aliases & Descriptions
28	RPS15	ribosomal protein S15	11.0	Summaries
29	ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	11.0	Publications
30	GSTP1	glutathione S-transferase pi 1	11.0	Publications
31	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	11.0	Publications
32	SPRR3	small proline-rich protein 3	11.0	Publications
33	HPSE	heparanase	11.0	Publications
34	CCND1	cyclin D1	11.0	Publications
35	CEACAM5	carcinoembryonic antigen-related cell adhesion molecule 5	11.0	Publications
36	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
37	GSTM1	glutathione S-transferase mu 1	11.0	Publications
38	RARB	retinoic acid receptor, beta	11.0	Publications
39	CDK4	cyclin-dependent kinase 4	11.0	Publications
40	FIGF	c-fos induced growth factor (vascular endothelial growth factor D)	11.0	Publications
41	MAGEA3	melanoma antigen family A, 3	11.0	Publications
42	MMP11	matrix metallopeptidase 11 (stromelysin 3)	11.0	Publications
43	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
44	DSG1	desmoglein 1	11.0	Publications
45	KRT14	keratin 14	11.0	Publications
46	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications
47	MTA1	metastasis associated 1	11.0	Publications
48	NME1	NME/NM23 nucleoside diphosphate kinase 1	11.0	Publications
49	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
50	VEGFC	vascular endothelial growth factor C	11.0	Publications

Pathways related to esophagitis according to GeneDecks:

(show top 50)    (show all 262)

id	Pathway	Score	Top Affiliating Genes
1	Pathways in cancer20	31.3	PIK3CB, PIK3CA, PIK3CG, RELA, RET, RB1
2	Antioxidant Action of Vitamin-C36	26.4	KIT, KITLG, VEGFC, BMP4, BMP6, BMP7
3	Tec Kinases Signaling36	26.2	KITLG, VEGFC, BMP4, BMP6, BMP7, RAC1
4	ERK Signaling36	25.0	KIT, KITLG, BRAF, VEGFC, MYC, MYLK
5	GSK3 Signaling36	23.9	KIT, KITLG, VEGFC, BMP4, BMP6, BMP7
6	TGF-Beta Pathway36	23.3	KITLG, VEGFC, BMP4, BMP6, BMP7, KDR
7	Nanog in Mammalian ESC Pluripotency36	22.3	KIT, KITLG, BRAF, VEGFC, BMP4, BMP6
8	cAMP Pathway36	22.3	KIT, KITLG, GCG, BRAF, VEGFC, BMP4
9	Cellular Apoptosis Pathway36	22.3	KIT, KITLG, VEGFC, VDAC1, BMP4, BMP6
10	NFAT in Immune Response36	22.2	KIT, KITLG, VEGFC, BMP4, BMP6, BMP7
11	GPCR Pathway36	22.1	KIT, KITLG, BRAF, VEGFC, BMP4, BMP6
12	p53 Mediated Apoptosis36	21.5	KIT, KITLG, VEGFC, BMP4, BMP6, BMP7
13	Transendothelial Migration of Leukocytes36	21.3	VCAM1, MYLK, RAC1, CLDN2, CLDN4, CLDN5
14	Intracellular Calcium Signaling36	21.3	KIT, KITLG, VEGFC, BMP4, BMP6, BMP7
15	Apoptotic Pathways in Synovial Fibroblasts36	19.8	KIT, KITLG, VEGFC, BMP4, BMP6, BMP7
16	Apoptosis and Autophagy3	18.7	PIK3C3, PIM1, PDCD4, SERPINB5, LMNA, MYC
17	ERK5 Signaling36	18.5	KIT, KITLG, VEGFC, MYC, BMP4, BMP6
18	P2Y Receptor Signaling36	18.2	KIT, BRAF, VEGFC, MYC, RAF1, KDR
19	Endothelin-1 Signaling Pathway36	17.9	KIT, BRAF, MYC, BMP4, BMP6, BMP7
20	Breast Cancer Regulation by Stathmin136	17.9	RB1CC1, BMP4, BMP7, RAF1, RAC1, PAK1
21	Influenza A20	17.3	PIK3CB, PIK3CA, PIK3CG, RELA, VDAC1, RAF1
22	CDC42 Pathway36	17.2	WASL, KIT, MYLK, RAF1, PAK1, PARD3
23	Angiogenesis3	17.2	RECK, SERPINB5, VHL, VEGFC, KDR, ITGA6
24	Glioblastoma Multiforme36	16.9	RB1, BRAF, RAF1, RAC1, FZD1, FZD10
25	Glioma Invasiveness36	16.6	KITLG, VEGFC, BMP4, BMP6, BMP7, CD44
26	Chemokine signaling pathway20	16.5	PIK3CB, PIK3CA, PIK3CG, RELA, WASL, BRAF
27	SOCS Pathway36	16.5	VEGFC, BMP4, BMP6, BMP7, BCL2, UBE2C
28	Apoptosis20	16.3	PIK3CB, PIK3CA, PIK3CG, RELA, BID, BIRC2
29	Wnt signaling pathway20	16.0	SFRP1, SFRP2, SFRP4, MYC, RAC1, AXIN2
30	all-trans-Retinoic Acid Signaling in Brain36	15.8	BMP4, BMP6, BMP7, RARA, RARB, BCL2
31	Bladder cancer20	15.7	RB1, BRAF, VEGFA, VEGFC, MYC, RAF1
32	ErbB signaling pathway20	15.6	PIK3CB, PIK3CA, PIK3CG, BRAF, MYC, RAF1
33	Sertoli-Sertoli Cell Junction Dynamics36	15.5	BRAF, RAF1, RAC1, CLDN2, CLDN4, CLDN5
34	Lymphocyte Signaling3	15.3	PIM1, NCAM1, KIT, KITLG, BMI1, RAG1
35	Development TGF-beta receptor signaling10	14.8	RELA, SERPINE1, RAF1, CHUK, XIAP, CDKN1A
36	Signal transduction_AKT signaling41	14.6	PIK3CB, PIK3CA, RELA, PCNA, MYC, BCL2L1
37	Development_Prolactin receptor signaling41	14.6	PIK3CB, PIK3CA, RELA, MYC, RAF1, RAC1
38	DNA Damage3	14.4	RBBP8, NBN, BRCA1, BRCA2, VCP, RAD52
39	Development_IGF-1 receptor signaling41	14.3	PIK3CB, PIK3CA, RELA, MYC, RAF1, BCL2L1
40	Actin-Based Motility by Rho Family GTPases36	14.0	WASL, MYLK, BMP4, BMP7, PAK1, PAK6
41	Apoptosis through Death Receptors36	14.0	BID, BIRC2, BIRC3, BCL2, CHUK, BAX
42	Development_VEGF signaling and activation41	13.9	PIK3CB, PIK3CA, RELA, SELE, BRCA1, VEGFA
43	Renal cell carcinoma20	13.9	PIK3CB, VHL, RAF1, RAC1, PAK1, PAK6
44	Signal transduction PTEN pathway10	13.8	PIK3CB, PIK3CA, PCNA, RAF1, BAD, MTOR
45	Apoptosis and survival Apoptotic TNF-family pathways10	13.7	BID, BIRC2, BCL2, BCL2L1, BAX, XIAP
46	Apoptosis and survival TNFR1 signaling pathway10	13.6	RELA, BRE, BID, BIRC2, BIRC3, CHUK
47	Colorectal cancer20	13.4	PIK3CB, PIK3CG, BRAF, RAC1, BAD, AXIN2
48	Development Thrombopoietin-regulated cell processes10	13.1	PIK3CB, PIK3CA, BRAF, MYC, RAF1, RAC1
49	Development_FGF-family signaling41	12.7	PIK3CB, PIK3CA, RAF1, RAC1, FGF1, FGF10
50	Apoptosis and survival Role of CDK5 in neuronal death and survival10	12.0	BCL2, BAD, CDK5, APAF1, CASP9, ERBB3

Compounds related to esophagitis according to GeneDecks:

(show top 50)    (show all 474)

id	Compound	Score	Top Affiliating Genes
1	atp32	40.6	PIK3CB, PIK3CA, PIK3C2A, PIM1, NCAM1, PDE4A
2	progesterone32 42 9 18 9	43.8	PIK3CA, NCAM1, NCOA3, PDE4A, KIT, KISS1
3	paclitaxel32 34 9 9	40.1	PIK3CA, PIK3CG, PIN1, KIT, KITLG, PCNA
4	cholesterol32 9 18 9	39.8	PIK3CB, PIK3CA, PIK3C2A, RECK, RELN, KITLG
5	glucose32	25.3	PDE4A, KIT, KISS1, GCG, SETD2, BRAF
6	ethanol32 34 9 18 9	28.8	NCAM1, KITLG, RBP1, BMP7, RARB, BID
7	cyclic amp32 18	25.4	KLF6, PDE4A, RET, CNR1, SFTPD, PCK2
8	folate32	24.4	RECK, RBP4, SELE, SERPINC1, SERPINA3, VIM
9	resveratrol32 9 18 9	27.1	PIK3CA, PIK3CG, PCNA, RB1, BSG, BRCA1
10	hydrogen32 18	24.6	PIN1, PIM1, PDE4A, RBP1, SERPINB2, BRCA1
11	camptothecin32 42 9 9	26.5	PIK3CG, PCNA, RB1, NBN, SETD2, BRCA1
12	norepinephrine32 9 18 9	25.7	PIK3C2A, PDE4A, CNR1, KITLG, GCG, SELE
13	p00232	22.4	KIT, RB1, RBP4, SERPINB5, BRAF, BRCA1
14	bromodeoxyuridine32	22.1	PIK3CA, NCAM1, NCOA3, KITLG, PCNA, RB1
15	polysaccharide32	21.4	NCAM1, NCOA3, RECK, KITLG, SFTPD, SELE
16	cytochalasin d32 42	21.8	PIK3CG, KITLG, SELE, SELL, VIM, LPL
17	gtp32	20.2	PIK3CA, PIK3C2A, RECK, PCK2, VIP, BRAF
18	pdtc32	19.4	PIK3CA, PIK3CG, SELE, SETD2, SERPINB5, VCAM1
19	potassium32 9 18 9	21.6	PIK3CA, PIK3C2A, NCAM1, PDE4A, KITLG, VIP
20	thalidomide32 42 9 9	21.4	PDE4A, SELL, VEGFA, BIRC2, BIRC3, BIRC5
21	sucrose32 9 18 9	21.1	RECK, GCG, RBP4, BSG, VDAC1, RAD51
22	latex32	17.7	WASL, KITLG, RBP4, VDAC1, LGALS3, CHEK2
23	4-hydroxynonenal32 18	18.0	MYC, PARP1, CHKA, CHAT, CHUK, BAX
24	trastuzumab32 34 9 9	19.8	PIK3CA, PIK3CG, KIT, VEGFC, RAF1, BIRC5
25	doxycycline32 9 9	18.7	CD79A, CDKN2B, CDKN2A, CDKN1C, MMP1, MMP13
26	daunorubicin32 9 9	18.4	RELA, KITLG, MYC, RAF1, BIRC5, BCL2
27	n-(4-hydroxyphenyl)retinamide32	16.3	RB1, RBP4, RBP1, VIM, MYC, BMP6
28	silymarin32	16.3	PCNA, VEGFA, BMP6, BIRC5, PARP1, CHUK
29	sodium dodecylsulfate32	16.2	SERPINF2, SERPINE1, LPL, VDAC1, MYC, BMP6
30	procollagen32	15.6	PCNA, SERPINH1, VIM, BMP6, LGALS1, CFP
31	melphalan32 9 9	17.6	PIK3C2A, RAD51, BIRC5, BCL2L1, MVP, MUC16
32	allergens32	15.5	SFTPD, LGALS3, S100A8, CD79A, CD86, CD14
33	leukotriene b432 42 18	17.3	PDE4A, SELL, RAC1, LCN2, MPO, ITGB2
34	rifampicin32	15.1	NAT2, UGT1A6, FASLG, GPT, HP, HNF4A
35	rotenone32	14.8	PIK3CG, PARP1, PARK7, BCL2, BCL2L1, UCP1
36	ionomycin32	14.8	PIK3CB, PIM1, SETD2, SERPINA3, RAG1, KCNMA1
37	colchicine32 9 9	16.7	PIK3C2A, VIM, BRCA1, CLU, CHKA, CHAT
38	b 72332	14.6	PCNA, VIM, CHKA, CHGA, MUC1, MUC16
39	cytosine32 18	15.5	RELN, SERPINB5, SERPINB2, BRCA1, RAD51, RASSF1
40	8-isoprostane32	14.5	SELE, SERPINE1, VCAM1, LEP, XDH, MPO
41	uric acid32 18	15.3	PIK3C2A, RBP4, SERPINE1, LGALS1, LEP, CHKA
42	pgd232	14.0	KITLG, IL13, IL5, CCL11, CCR3, IGHE
43	raloxifene32 9 9	16.0	NCOA3, SERPINC1, SERPINE1, VDR, JUN, CD36
44	neomycin32	13.6	KITLG, PCK2, VIM, CEACAM5, CDKN2A, FGF4
45	cerivastatin32 9 9	15.6	PIK3C2A, SERPINE1, RAC1, MMP1, CCL2, CCL5
46	polyinosinic-polycytidylic acid32	13.3	SELE, VCAM1, IRF1, IRF3, IL10, IL12B
47	il 1032	13.1	VDR, BMP6, IL10, IL10RA, IL12B, IL13
48	tpck32	13.0	PIK3CG, PARP1, BCL2L1, BAK1, JUN, IL1B
49	bisindolylmaleimide32	12.6	PIK3CB, RAF1, RAC1, S100B, CFLAR, ITGA2
50	Adenosine triphosphate9 18 9	INF	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIK3C3, PIM1

Cellular components related to esophagitis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	INF	ZNF410, ZNF135, ZNF24, ZNF639, ZNF207, ZNF624
2	plasma membrane	GO:005886	51.3	PIK3C2A, PIK3CG, PIM1, NCAM1, PDCD1LG2, RECK
3	extracellular region	GO:005576	39.9	NCAM1, PDCD1LG2, REG1A, REG1B, KISS1, KITLG
4	nucleoplasm	GO:005654	36.0	PIN1, WDHD1, NCOA3, RELA, REV1, PCNA
5	extracellular space	GO:005615	35.1	RELN, KIT, KITLG, SFN, SFRP1, SFRP2
6	integral to plasma membrane	GO:005887	27.9	LRMP, RET, CNR1, SELL, CLDN4, CLDN1
7	cell surface	GO:009986	21.3	NCAM1, KISS1R, SFRP1, SFRP4, VEGFA, LPL
8	perinuclear region of cytoplasm	GO:048471	19.1	PDE4A, BUB1B, SELE, LMNA, RAD51, LIMS1
9	external side of plasma membrane	GO:009897	16.2	NCAM1, KIT, SELL, VCAM1, KDR, CD79A
10	caveola	GO:005901	13.6	SELE, KCNMA1, ATP1B1, CDH13, IRS1, FASLG
11	cytosol	GO:005829	INF	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIK3C3, PDCD4
12	cytoplasm	GO:005737	INF	PIK3C2A, PIK3CG, PIN1, PIM1, WDHD1, KLF6

Biological processes related to esophagitis according to GeneDecks:

(show top 50)    (show all 68)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription from RNA polymerase II promoter	GO:045944	31.0	KLF4, KLF6, NCOA3, RELA, SFRP2, RB1
2	signal transduction	GO:007165	30.5	PIK3CB, PDE4A, RET, KIT, KITLG, SFN
3	apoptotic process	GO:006915	30.0	PIM1, PDCD4, PDCD5, SFN, BUB1B, NBN
4	positive regulation of transcription, DNA-dependent	GO:045893	27.4	KLF4, KLF5, KLF6, NCOA3, RELA, RET
5	negative regulation of transcription from RNA polymerase II promoter	GO:000122	26.1	KLF4, RBBP8, VHL, VDR, MYC, BMI1
6	positive regulation of cell proliferation	GO:008284	26.0	KLF5, REG1A, KIT, SFRP1, SFRP2, NBN
7	negative regulation of apoptotic process	GO:043066	24.4	PIK3CG, PIM1, RELA, SFRP1, GCG, RB1CC1
8	negative regulation of cell proliferation	GO:008285	24.4	KLF4, KISS1R, SFN, SFRP1, SFRP2, SFRP4
9	response to drug	GO:042493	24.4	PDE4A, SFRP1, SFRP2, NBN, VEGFC, LPL
10	blood coagulation	GO:007596	21.9	PIK3CB, PIK3CA, PIK3CG, KIF22, SELL, SERPINC1
11	cell proliferation	GO:008283	21.5	PIM1, REG1B, KITLG, SFN, PCNA, BUB1B
12	anti-apoptosis	GO:006916	20.7	PIK3CA, RELA, SERPINB2, NAIP, BRAF, VHL
13	negative regulation of transcription, DNA-dependent	GO:045892	20.4	ZNF24, ZNF639, KLF4, PDCD4, RELA, SFRP1
14	virus-host interaction	GO:019048	20.3	RELA, RB1, RBL1, VIM, VDAC1, VCAM1
15	inflammatory response	GO:006954	20.2	PIK3CG, RELA, KIT, SELE, SERPINA3, BMP6
16	response to hypoxia	GO:001666	19.4	VEGFA, VCAM1, RAF1, CLDN3, PAK1, BCL2
17	induction of apoptosis	GO:006917	19.3	PDCD5, NAIF1, ZMAT3, BAD, BAX, CEBPB
18	DNA repair	GO:006281	19.0	REV1, KIF22, PCNA, RBBP8, NBN, BRCA1
19	cell-cell signaling	GO:007267	18.7	SFRP2, S100A9, CGA, FZD1, FZD2, CD86
20	angiogenesis	GO:001525	18.5	PIK3CA, PIK3CG, KLF5, SETD2, SERPINE1, VEGFA
21	positive regulation of apoptotic process	GO:043065	18.3	CNR1, SFRP1, SFRP2, SFRP4, BMP4, RARB
22	positive regulation of cell migration	GO:030335	17.9	RET, VEGFA, MYLK, KDR, CGA, CDH13
23	cell surface receptor signaling pathway	GO:007166	17.7	BSG, BIRC2, BIRC3, LEPR, BAG1, CD36
24	response to lipopolysaccharide	GO:032496	16.7	CNR1, SELE, S100A14, S100A8, S100A9, CEBPB
25	transcription initiation from RNA polymerase II promoter	GO:006367	16.7	RBL1, SERPINE1, VDR, MYC, RARA, RARB
26	cell cycle arrest	GO:007050	16.5	RB1, NBN, MYC, RASSF1, BARD1, MSH2
27	xenobiotic metabolic process	GO:006805	16.3	NAT1, NAT2, UGT1A4, UGT1A6, MTR, S100A12
28	platelet activation	GO:030168	16.3	PIK3CB, PIK3CA, PIK3CG, SERPINF2, SERPINE1, VEGFA
29	heart development	GO:007507	16.2	PCNA, RBP4, RB1CC1, VCAM1, RAF1, ATM
30	response to organic cyclic compound	GO:014070	15.7	SFRP1, BMP4, BAK1, MSH2, ATF1, ATP12A
31	response to ethanol	GO:045471	15.6	CNR1, RBP4, BCL2, CHAT, BAK1, S100A8
32	positive regulation of gene expression	GO:010628	15.6	NCOA3, CNTN1, KIT, SFRP4, BRAF, VEGFA
33	positive regulation of protein phosphorylation	GO:001934	15.1	PIN1, RB1CC1, VEGFA, BMP4, MT3, MTOR
34	nerve growth factor receptor signaling pathway	GO:048011	15.1	PIK3CB, PIK3CA, RELA, BRAF, RAF1, RAC1
35	negative regulation of neuron apoptotic process	GO:043524	15.0	NAIP, BRAF, LIG4, PARK7, BCL2, BCL2L1
36	response to estradiol stimulus	GO:032355	14.8	SFRP4, BRCA2, VDR, BMP4, RARA, BID
37	fibroblast growth factor receptor signaling pathway	GO:008543	14.7	PIK3CA, BRAF, RAF1, CHUK, BAD, MTOR
38	positive regulation of angiogenesis	GO:045766	14.7	SFRP2, SERPINE1, VEGFA, KDR, MTDH, CD34
39	response to estrogen stimulus	GO:043627	14.6	SERPINE1, BRCA1, BCL2, CD24, GSTM3, FAS
40	positive regulation of ERK1 and ERK2 cascade	GO:070374	14.5	GCG, SERPINF2, BRAF, BMP4, KDR, MT3
41	wound healing	GO:042060	14.4	KLF6, RAF1, PAK1, SDC2, S100A8, FGF10
42	phosphatidylinositol-mediated signaling	GO:048015	14.3	PIK3CB, PIK3CA, PIK3C2A, PIK3C3, PCNA, BUB1B
43	positive regulation of cell division	GO:051781	14.2	VEGFA, VEGFC, YBX1, FIGF, FGF1, FGF2
44	aging	GO:007568	14.1	CNR1, VDR, VCAM1, BAK1, JUN, IL15
45	response to glucocorticoid stimulus	GO:051384	13.9	SFRP4, PCK2, SERPINE1, IL10, IL1B, IL1RN
46	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	13.9	RELN, KIT, KDR, FLT1, FGFR1, ANGPT1
47	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	13.8	RELN, KITLG, VEGFA, MTOR, CD36, CD80
48	positive regulation of smooth muscle cell proliferation	GO:048661	13.6	SERPINF2, BMP4, JUN, CDH13, FLT1, IL13
49	small molecule metabolic process	GO:044281	INF	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIK3C3, NCOA3
50	cytokine-mediated signaling pathway	GO:019221	INF	PIN1, KLF6, NCAM1, RELA, KIT, VCAM1

Molecular functions related to esophagitis according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	99.7	ZNF24, ZNF639, PIK3CB, PIK3CA, PIK3CG, PIN1
2	ATP binding	GO:005524	30.3	PIK3CB, PIK3CA, PIK3C2A, PIK3CG, PIK3C3, PIM1
3	sequence-specific DNA binding transcription factor activity	GO:003700	28.7	ZNF135, ZNF24, ZNF639, ZNF207, KLF4, KLF5
4	protein homodimerization activity	GO:042803	26.2	KIT, SERPINF2, VEGFA, BMP4, RAG1, BIRC5
5	identical protein binding	GO:042802	20.4	RELA, SFRP1, PCNA, VIM, VCP, RAD51
6	transcription factor binding	GO:008134	19.1	PIM1, RELA, RB1, RBL1, NBN, VHL
7	growth factor activity	GO:008083	18.4	REG1A, KITLG, VEGFA, VEGFC, BMP4, BMP6
8	receptor binding	GO:005102	18.4	GCG, SERPINE1, LPL, VCP, RARA, PANX1
9	transcription regulatory region DNA binding	GO:044212	18.3	ZNF639, KLF4, RELA, BRCA1, YAP1, XRCC5
10	protein heterodimerization activity	GO:046982	18.3	BRAF, VEGFA, MYC, BMP6, RARA, RAF1
11	enzyme binding	GO:019899	17.8	BRCA1, VHL, RARA, RAC1, BIRC5, BIRC7
12	protein kinase binding	GO:019901	17.4	RELA, RB1CC1, VIM, PAK1, BCL2L1, ULK1
13	cytokine activity	GO:005125	15.3	KITLG, VEGFA, BMP4, BMP6, BMP7, SCGB3A1
14	heparin binding	GO:008201	14.7	SFRP1, SELL, SERPINC1, VEGFA, LPL, BMP4
15	drug binding	GO:008144	13.4	CNR1, SFRP1, CHKA, CHRM2, CHRM3, UGT1A8
16	sequence-specific DNA binding	GO:043565	INF	ZNF24, RERE, VDR, MYC, RAG1, RARA