MCID: ESP024
MIFTS: 51

Esophagitis malady

Summaries for Esophagitis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Esophagitis (or oesophagitis) is inflammation of the esophagus. It may be acute or chronic. Acute... more...

MalaCards: Esophagitis, also known as acute esophagitis, is related to squamous cell carcinoma and esophageal squamous cell carcinoma. An important gene associated with Esophagitis is DEC1 (deleted in esophageal cancer 1), and among its related pathways are Signaling events mediated by the Hedgehog family and Glypican 3 network. The drugs omeprazole and sucralfate and the compound cyclopamine have been mentioned in the context of this disorder. Related mouse phenotypes are digestive/alimentary and integument.

Aliases & Classifications for Esophagitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Aliases & Descriptions:

esophagitis 8 10 45 61
acute esophagitis 8 61


External Ids:

Disease Ontology8 DOID:11963
ICD9CM27 530.1, 530.10
MeSH35 D004941
NCIt40 C9224

Related Diseases for Esophagitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Esophagitis family:

bacterial esophagitis viral esophagitis

Diseases related to Esophagitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 677)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma31.9FHIT, CTAG1B, CTSB, KDM4C, KRT4, PTCH1
2esophageal squamous cell carcinoma31.9DEC1, LZTS1
3adenocarcinoma31.7FHIT, CTAG1B, CTSB, KRT4, PTCH1
4stomach cancer30.2FHIT, CTAG1B, CTSB, PTCH1
5basal cell carcinoma29.9PTCH1, SHH
6pallister-hall syndrome29.7SHH
7bladder carcinoma29.5LZTS1, FHIT, CTAG1B, PTCH1
8esophageal atresia11.1
9eosinophilic esophagitis11.1
10tracheoesophageal fistula10.9
11esophageal atresia/tracheoesophageal fistula10.8
12achalasia10.8
13barrett esophagus/esophageal adenocarcinoma10.8
14esophageal candidiasis10.7
15peptic esophagitis10.7
16barrett's esophagus10.7
17gastroesophageal reflux disease10.7
18anal squamous cell carcinoma10.6
19esophageal duplication cyst10.6
20barrett's adenocarcinoma10.6
21dysphagia10.6
22esophageal tuberculosis10.6
23tuberculosis10.6
24esophageal varix10.5
25cardia cancer10.5
26gastric squamous cell carcinoma10.5
27gastric cardia adenocarcinoma10.5
28thoracic cancer10.4
29small cell carcinoma10.4
30duodenal atresia10.4
31tylosis with esophageal cancer10.4
32vacterl association10.3
33portal hypertension10.3
34hypoxia10.3
35squamous cell papilloma10.3
36duodenal ulcer10.3
37megaesophagus10.3
38congenital diaphragmatic hernia10.3
39esophageal lipoma10.3
40vascular cancer10.3
41bronchogenic cyst10.3
42bile reflux10.3
43h. pylori infection10.3
44idiopathic achalasia10.3
45gastric ulcer10.3
46granular cell tumor10.3
47recessive dystrophic epidermolysis bullosa10.3
48lichen planus10.3
49gastrointestinal stromal tumor10.3
50viral esophagitis10.3

Graphical network of the top 20 diseases related to Esophagitis:



Diseases related to esophagitis

Clinical Features for Esophagitis

Drugs & Therapeutics for Esophagitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Esophagitis

Drug clinical trials:

Search ClinicalTrials for Esophagitis

Search NIH Clinical Center for Esophagitis

Search CenterWatch for Esophagitis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Esophagitis

Anatomical Context for Esophagitis

Animal Models for Esophagitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Esophagitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538111.7FHIT, CTSB, ATP4A, SHH, KRT4, PTCH1
2MP:001077111.6FHIT, CTSB, SHH, CLDN6, KDM4C, KRT4

Publications for Esophagitis

Sources:
51PubMed
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Articles related to Esophagitis:

(show top 50)    (show all 986)
idTitleAuthorsYear
1
Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. (23872715)
2013
2
The association between celiac disease and eosinophilic esophagitis in children and adults. (23721294)
2013
3
A technique to use CT images for in vivo detection and quantification of the spatial distribution of radiation-induced esophagitis. (23652249)
2013
4
Esophagitis and Widespread Aphthous Ulcerations in Gastric Mucosa in An Infant with Familial Mediterranean Fever. (23492736)
2013
5
Emerging Therapeutic Strategies for Eosinophilic Esophagitis. (24370990)
2013
6
Herpes simplex virus and eosinophilic esophagitis. (22343907)
2013
7
A tailored vs empiric diet--which is best for eosinophilic esophagitis? (23623872)
2013
8
Eosinophilic esophagitis: review of nonsurgical treatment modalities. (23998238)
2013
9
Pulmonary embolism in a patient with eosinophilic esophagitis: causal or coincidental? (23626508)
2013
10
The first experience of eosinophilic esophagitis in Turkish children. (22505372)
2012
11
Endoscopic ablative therapy for Barrett's esophagus: a potential cause of eosinophilic esophagitis. (21668572)
2012
12
The early anti-inflammatory effect of Kefir in experimental corrosive esophagitis. (23013643)
2012
13
Eosinophilic esophagitis-endoscopic distinguishing findings. (22919257)
2012
14
Increased incidence of endoscopic erosive esophagitis in solid organ transplant recipients. (22844564)
2012
15
Efficacy of leukotriene receptor antagonist for erosive esophagitis: a preliminary retrospective comparative study. (22211520)
2012
16
Barrett's esophagus, reflux esophagitis, and eosinophilic esophagitis. (22855068)
2012
17
Montelukast and maintenance of steroid-induced remission in eosinophilic esophagitis. (21987280)
2012
18
Eosinophilic esophagitis: which role for food and inhalant allergens? (23130328)
2012
19
Nonerosive gastroesophageal reflux disease and mild degree of esophagitis: comparison of symptoms endoscopic, manometric and pH-metric patterns. (22591510)
2012
20
Medication-induced esophageal tattoo in a patient with eosinophilic esophagitis. (20619833)
2011
21
Microscopic esophagitis and Barrett's esophagus: the histology report. (21459338)
2011
22
Esophagitis and Barrett esophagus: unifying the definitions and diagnostic approaches, with special reference to esophageal atresia. (21499040)
2011
23
Allergy assessment in children with eosinophilic esophagitis. (21370725)
2011
24
Severe dysphagia in children with eosinophilic esophagitis and esophageal stricture: an indication for balloon dilation? (19934772)
2010
25
Eosinophilic esophagitis: clinical features, endoscopic findings and response to treatment. (21152459)
2010
26
An update on the immunopathogenesis of eosinophilic esophagitis. (20350261)
2010
27
Incidental gastric eosinophils in patients with eosinophilic esophagitis: do they matter? (20601904)
2010
28
Eosinophilic esophagitis: the newest esophageal inflammatory disease. (19404267)
2009
29
Eosinophilic esophagitis. (19115464)
2009
30
Eosinophilic esophagitis. (19554448)
2009
31
Eosinophilic esophagitis in adults. (18499024)
2008
32
Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis. (17592361)
2007
33
The elucidation of peptic esophagitis: from Hamperl to heartburn. (18027318)
2007
34
Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease. (17900656)
2007
35
Free radicals and antioxidant systems in reflux esophagitis and Barrett's esophagus. (15884106)
2005
36
Prevalence of reflux esophagitis in patients with duodenal ulcer and gastric ulcer. (12768398)
2003
37
Reflux esophagitis and hiatal hernia as concomitant abnormality in patients presenting with active duodenal or gastric ulcer: cross-sectional endoscopic study in consecutive patients. (12020629)
2002
38
No protective role of Helicobacter pylori in the pathogenesis of reflux esophagitis in patients with duodenal or benign gastric ulcer in Korea. (11768266)
2001
39
Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. (11742273)
2001
40
Effect of long-term, continuous versus alternate-day omeprazole therapy on serum gastrin in patients treated for reflux esophagitis. (11418787)
2001
41
Esophagitis in infants with hypertrophic pyloric stenosis: a source of hematemesis. (8429475)
1993
42
Esophageal motor abnormalities in children with gastroesophageal reflux and peptic esophagitis. (3712155)
1986
43
Squamous cell papilloma of the esophagus. Report of a case after peptic esophagitis and repeated bougienage with review of the literature. (640347)
1978
44
Stenosing non-peptic esophagitis. (5377467)
1969
45
Problems in the early diagnosis of peptic esophagitis. (6037461)
1967
46
Erosive ("peptic") esophagitis. (13860367)
1962
47
Peptic esophagitis and peptic ulceration of the esophagus. (13521128)
1958
48
Esophageal stenosis caused by peptic esophagitis or ulceration. (13154601)
1954
49
PEPTIC esophagitis. (13201417)
1954
50
Stenosing peptic esophagitis. With a report of the results of treatment in 22 cases. (14842134)
1951

Genetic Variations for Esophagitis

Expression for genes affiliated with Esophagitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Esophagitis

Search GEO for disease gene expression data for Esophagitis.

Pathways for genes affiliated with Esophagitis

Sources:
38NCBI BioSystems Database
See all sources

Pathways related to Esophagitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9PTCH1, SHH
210.9PTCH1, SHH

Compounds for genes affiliated with Esophagitis

Sources:
45Novoseek, 60Tocris Bioscience
See all sources

Compounds related to Esophagitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclopamine45 6011.9PTCH1, SHH

GO Terms for genes affiliated with Esophagitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somite developmentGO:06105310.9PTCH1, SHH
2spinal cord motor neuron differentiationGO:02152210.9PTCH1, SHH
3renal system developmentGO:07200110.8PTCH1, SHH
4negative regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243510.6SHH, FHIT

Molecular functions related to Esophagitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1patched bindingGO:00511310.9PTCH1, SHH

Products for genes affiliated with Esophagitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophagitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet