MCID: ESP025
MIFTS: 51

Esophagus Adenocarcinoma malady

Summaries for Esophagus Adenocarcinoma

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32MalaCards
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MalaCards: Esophagus Adenocarcinoma, also known as adenocarcinoma of esophagus, is related to barrett's esophagus and adenocarcinoma. An important gene associated with Esophagus Adenocarcinoma is MTMR9 (myotubularin related protein 9), and among its related pathways are GPCR Pathway and Colorectal Cancer Metastasis. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include bone, colon and liver, and related mouse phenotypes are embryogenesis and adipose tissue.

Aliases & Classifications for Esophagus Adenocarcinoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

esophagus adenocarcinoma 8
adenocarcinoma of esophagus 8 60
oesophageal adenocarcinoma nos 8


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Disease Ontology8 DOID:4914
SNOMED-CT56 276803003
NCIt39 C4025

Related Diseases for Esophagus Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Esophagus Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1barrett's esophagus30.5TGFA, TP53, PTGS2, SI, CDKN2A, MKI67
2adenocarcinoma30.4CCND1, S100A8, EGFR, MKI67, CDKN2A, CDKN1A
3esophagitis30.2S100A8
4esophageal cancer30.2CCND1, CDKN2A, TP53, TGFA
5squamous cell carcinoma30.0CCND1, EGFR, MKI67, TGFA
6barrett's adenocarcinoma10.4
7gastroesophageal junction adenocarcinoma10.0
8esophagus squamous cell carcinoma10.0
9meningitis10.0
10barrett esophagus/esophageal adenocarcinoma10.0
11gingivitis10.0SI
12duodenitis10.0S100A8
13gastroesophageal reflux disease10.0S100A8
14gastric lymphoma10.0S100A8
15diabetes mellitus10.0SI
16pituitary tumors10.0TGFA
17malignant mesothelioma10.0CDKN2A
18parathyroid adenoma10.0CCND1
19gastrointestinal stromal tumor10.0MKI67
20pulmonary fibrosis10.0TGFA
21leiomyoma10.0MKI67
22pituitary adenoma10.0MKI67
23leukoplakia10.0MKI67
24smooth muscle tumor10.0MKI67
25hemangioblastoma10.0TGFA
26uterine carcinosarcoma10.0PTGS2
27endometriosis10.0PTGS2
28asthma10.0S100A8
29hypercalcemia10.0TGFA
30duodenal ulcer10.0S100A8
31tongue cancer10.0CDKN1A
32benign meningioma10.0MKI67
33primary hyperoxaluria10.0PTGS2
34fibrosarcoma10.0CDKN1A
35biliary tract neoplasm10.0EGFR
36atherosclerosis10.0PTGS2
37gastrointestinal system disease10.0PTGS2
38cholesteatoma10.0S100A8, TGFA
39psoriasis10.0S100A8, TGFA
40myocardial infarction10.0PTGS2
41cervical intraepithelial neoplasia10.0CDKN2A, MKI67
42giant cell glioblastoma10.0EGFR
43meningioma10.0TGFA, MKI67
44thoracic cancer10.0CDKN1A
45leiomyosarcoma10.0TP53
46ulcerative colitis10.0TP53
47arthritis10.0PTGS2, S100A8
48medulloblastoma10.0TP53
49dermatomyositis10.0S100A8
50gallbladder cancer10.0TP53

Graphical network of the top 20 diseases related to Esophagus Adenocarcinoma:



Diseases related to esophagus adenocarcinoma

Clinical Features for Esophagus Adenocarcinoma

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Drugs & Therapeutics for Esophagus Adenocarcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Esophagus Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Esophagus Adenocarcinoma

Search NIH Clinical Center for Esophagus Adenocarcinoma

Search CenterWatch for Esophagus Adenocarcinoma

Genetic Tests for Esophagus Adenocarcinoma

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Anatomical Context for Esophagus Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Esophagus Adenocarcinoma:

32
Bone, Colon, Liver, Pancreas, Endothelial

Animal Models for Esophagus Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Esophagus Adenocarcinoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.0S100A8
2MP:00053759.9TGFA
3MP:00053679.9EGFR
4MP:00053919.5TGFA, EGFR
5MP:00036319.4CDKN1A, BCL2
6MP:00053909.2TGFA, CDKN1A, CCND1
7MP:00053798.9CCND1, CDKN2A, CDKN1A, BCL2, TP53
8MP:00053698.8CDKN2A, CDKN1A, TP53, TGFA
9MP:00053708.5EGFR, CDKN2A, CDKN1A, PTGS2, TP53
10MP:00030128.5TP53, PTGS2, CDKN1A, CDKN2A, EGFR
11MP:00053888.3CCND1, EGFR, CDKN1A, PTGS2, BCL2, TP53
12MP:00020068.1CCND1, EGFR, CDKN2A, CDKN1A, PTGS2, BCL2
13MP:00053977.9CCND1, EGFR, CDKN2A, CDKN1A, PTGS2, BCL2
14MP:00053827.8CCND1, EGFR, CDKN1A, BCL2, TP53, TGFA
15MP:00107717.8CCND1, CDKN2A, CDKN1A, PTGS2, BCL2, TP53
16MP:00053857.4CCND1, EGFR, CDKN1A, PTGS2, BCL2, TP53
17MP:00053817.3TGFA, CCND1, EGFR, CDKN2A, CDKN1A, PTGS2
18MP:00053897.2CCND1, EGFR, CDKN2A, CDKN1A, PTGS2, BCL2
19MP:00053877.1CCND1, EGFR, CDKN2A, CDKN1A, PTGS2, BCL2
20MP:00107687.1CCND1, S100A8, EGFR, CDKN2A, CDKN1A, PTGS2
21MP:00053787.1CCND1, EGFR, CDKN2A, CDKN1A, PTGS2, BCL2

Publications for Esophagus Adenocarcinoma

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50PubMed
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Articles related to Esophagus Adenocarcinoma:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
Association between markers of obesity and progression from Barrett's esophagus to esophageal adenocarcinoma. (23466711)
2013
2
Small Barrett's adenocarcinoma, 3 mm in size, in long-segment Barrett's esophagus detected after 4 years of follow up. (23617677)
2013
3
Long-term Efficacy and Safety of Endoscopic Resection for Patients With Mucosal Adenocarcinoma of the Esophagus. (24269290)
2013
4
High-grade dysplasia and intramucosal adenocarcinoma in Barrett's esophagus: the role of esophagectomy in the era of endoscopic eradication therapy. (22517568)
2012
5
NcoI TNF-I^ gene polymorphism and TNF expression are associated with an increased risk of developing Barrett's esophagus and esophageal adenocarcinoma. (22243485)
2012
6
Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett Esophagus? (22261707)
2012
7
Cigarette smoking increases risk of Barrett's esophagus: an analysis of the Barrett's and Esophageal Adenocarcinoma Consortium. (22245667)
2012
8
Use of statin medications and risk of esophageal adenocarcinoma in persons with Barrett's esophagus. (22241250)
2012
9
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. (21951971)
2012
10
Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon. (22542127)
2012
11
Myo9B is associated with an increased risk of Barrett's esophagus and esophageal adenocarcinoma. (22954106)
2012
12
Barrett's esophagus: treatments of adenocarcinomas II. (21950818)
2011
13
Prevalence of Barrett esophagus in first-degree relatives of patients with esophageal adenocarcinoma. (21617543)
2011
14
Barrett's esophagus: progression to adenocarcinoma and markers. (21950815)
2011
15
Patients with nondysplastic Barrett's esophagus have low risks for developing dysplasia or esophageal adenocarcinoma. (21115133)
2011
16
Primary pure signet ring cell adenocarcinoma of non-Barrett's esophagus. (22275019)
2011
17
Incidence of adenocarcinoma among patients with Barrett's esophagus. (21995385)
2011
18
Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma. (21977915)
2011
19
Enhanced PPAR-gamma expression may correlate with the development of Barrett's esophagus and esophageal adenocarcinoma. (21473290)
2011
20
MicroRNA alterations in Barrett's esophagus, esophageal adenocarcinoma, and esophageal adenocarcinoma cell lines following cranberry extract treatment: Insights for chemoprevention. (22279419)
2011
21
Genetic variations in angiogenesis pathway genes predict tumor recurrence in localized adenocarcinoma of the esophagus. (20101173)
2010
22
Gene amplification of ERBB2 and EGFR in adenocarcinoma in situ and intramucosal adenocarcinoma of Barrett's esophagus. (20518902)
2010
23
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma. (20128019)
2010
24
Esophageal adenocarcinoma after Nissen's fundoplication for Barrett's esophagus: report of a case. (21110164)
2010
25
Oral bisphosphonate prescriptions and the risk of esophageal adenocarcinoma in patients with Barrett's esophagus. (20397052)
2010
26
Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma. (19670330)
2009
27
Barrett's Esophagus and esophageal adenocarcinoma. (18783330)
2009
28
Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. (17849424)
2008
29
Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus. (18331622)
2008
30
The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma. (17575500)
2007
31
Reflux injury of esophageal mucosa: experimental studies in animal models of esophagitis, Barrett's esophagus and esophageal adenocarcinoma. (17760649)
2007
32
Molecular prognostic factors in adenocarcinoma of the esophagus and gastroesophageal junction. (17122988)
2007
33
Proinflammatory cytokine and nuclear factor kappa-B expression along the inflammation-metaplasia-dysplasia-adenocarcinoma sequence in the esophagus. (15929754)
2005
34
Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas. (15967118)
2005
35
p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations. (15617840)
2005
36
Overexpression of decoy receptor 3 in precancerous lesions and adenocarcinoma of the esophagus. (16040301)
2005
37
Surface expression of minichromosome maintenance proteins provides a novel method for detecting patients at risk for developing adenocarcinoma in Barrett's esophagus. (12855631)
2003
38
Parathyroid hormone-related protein production by adenocarcinoma in Barrett's esophagus patient with dermatomyositis. (11478513)
2001
39
Barrett's adenocarcinoma of the esophagus with lymphoid stroma. (11468442)
2001
40
Composite tumor with papillary adenocarcinoma and squamous cell carcinoma of the esophagus: report of a case. (10795870)
2000
41
HER-2/neu gene amplification by FISH predicts poor survival in Barrett's esophagus-associated adenocarcinoma. (10665910)
2000
42
Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure. (10702199)
2000
43
P53 mutational status improves estimation of prognosis in patients with curatively resected adenocarcinoma in Barrett's esophagus. (10955797)
2000
44
Expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) and p53 tumor suppressor in dysplastic progression and adenocarcinoma in Barrett esophagus. (10463972)
1999
45
Meningeal carcinomatosis in patient with esophagus adenocarcinoma. (9105327)
1997
46
Is Barrett's esophagus the precursor of most adenocarcinomas of the esophagus and cardia? A biochemical study. (9409571)
1997
47
Barrett's esophagus: metaplastic cells with loss of heterozygosity at the APC gene locus are clonal precursors to invasive adenocarcinoma. (8616831)
1996
48
Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. (7742727)
1995
49
Chemopreventive studies in Barrett's esophagus: a model premalignant lesion for esophageal adenocarcinoma. (1389696)
1992
50
Adenocarcinoma in situ of Barrett's esophagus diagnosed by endoscopic cytology. (4411868)
1974

Genetic Variations for Esophagus Adenocarcinoma

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Expression for genes affiliated with Esophagus Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophagus Adenocarcinoma

Search GEO for disease gene expression data for Esophagus Adenocarcinoma.

Pathways for genes affiliated with Esophagus Adenocarcinoma

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Sources:
51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore, 55SinoBiological, 52R&D Systems, 53Reactome, 4Cell Signaling Technology, 49PharmGKB
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Pathways related to Esophagus Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0TP53
210.0EGFR
39.8CDKN1A, CCND1
4
Hide members
9.6BCL2, TP53
59.5BCL2, EGFR
6
Cell cycle Cell cycle (generic schema)
Hide members
9.5CDKN1A, CDKN2A, CCND1
7
Hide members
9.4BCL2, CDKN1A, CCND1
89.4CCND1, CDKN1A, BCL2
9
Hide members
9.3TP53, CDKN1A, CCND1
109.3CCND1, CDKN1A, TP53
119.3CDKN1A, CCND1, TP53
12
Hide members
9.3CDKN2A, TP53, CDKN1A
13
Hide members
9.3CCND1, BCL2, TP53
14
Transcription Androgen Receptor nuclear signaling
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9.3CDKN1A, EGFR, CCND1
159.3CDKN1A, EGFR, CCND1
16
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
9.2CDKN1A, BCL2, TP53
179.2CDKN1A, BCL2, TP53
189.2TP53, CCND1, EGFR
199.1TP53, EGFR, CDKN1A
209.1EGFR, TP53, CDKN1A
219.0CDKN1A, PTGS2, BCL2, CCND1
229.0TP53, CDKN1A, CDKN2A, CCND1
23
Hide members
9.0TP53, CDKN2A, CCND1, CDKN1A
249.0CDKN2A, CDKN1A, CCND1, TP53
25
Hide members
9.0CDKN1A, CCND1, CDKN2A, TP53
269.0BCL2, TP53, CCND1, PTGS2
27
Hide members
9.0CCND1, CDKN2A, MKI67, CDKN1A
28
Hide members
8.9CCND1, CDKN1A, TP53, BCL2
298.9TP53, CDKN2A, BCL2, CDKN1A
30
Transcription P53 signaling pathway
Hide members
8.9CDKN1A, TP53, CDKN2A, BCL2
318.9BCL2, CDKN1A, CDKN2A, TP53
32
Hide members
8.9EGFR, CCND1, BCL2, PTGS2
33
Hide members
8.8CDKN1A, TP53, TGFA
348.8CDKN1A, CCND1, EGFR, TP53
358.8TP53, CCND1, BCL2, EGFR
36
Hide members
8.7EGFR, PTGS2, TP53, BCL2
37
Hide members
8.6CCND1, BCL2, TP53, CDKN2A, CDKN1A
388.5TP53, EGFR, CDKN2A, CDKN1A, CCND1
398.4TP53, CDKN1A, EGFR, CCND1, BCL2
40
Hide members
8.4TP53, BCL2, CDKN1A, CCND1, EGFR
41
Hide members
8.4PTGS2, TP53, EGFR, BCL2, CDKN1A
428.1CDKN1A, PTGS2, BCL2, CCND1, TP53, EGFR
43
Hide members
8.0CDKN1A, TP53, CCND1, EGFR, TGFA
44
Hide members
7.9CDKN2A, EGFR, BCL2, TGFA, TP53
457.9CDKN1A, TP53, TGFA, EGFR, BCL2
467.7CCND1, EGFR, CDKN2A, CDKN1A, PTGS2, BCL2
47
Hide members
7.7TGFA, TP53, CDKN2A, EGFR, CCND1, CDKN1A
48
Hide members
7.6EGFR, TP53, CCND1, TGFA, CDKN1A, BCL2
49
Hide members
6.9TGFA, TP53, BCL2, PTGS2, CDKN1A, CDKN2A
506.9PTGS2, CCND1, EGFR, CDKN2A, CDKN1A, TGFA

Compounds for genes affiliated with Esophagus Adenocarcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Esophagus Adenocarcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6SI
2butyrate4410.6SI
3resveratrol44 59 11 2413.1TGFA
4vincristine44 49 1111.9CCND1, MKI67
5depsipeptide449.8TP53, CDKN2A, CCND1
6sulindac sulfide449.3TP53, BCL2, PTGS2, CCND1
7serine449.3S100A8, MKI67, CCND1
8temozolomide44 1110.1EGFR, CDKN2A, TP53, CDKN1A
9olomoucine44 1110.1TP53, BCL2, CDKN1A, CDKN2A, CCND1
10sulindac44 1110.0CCND1, CDKN1A, PTGS2, BCL2, TP53
11taxane449.0CDKN1A, EGFR, TP53, BCL2
12roscovitine449.0CDKN1A, CCND1, CDKN2A, BCL2, TP53
13indole-3-carbinol448.9BCL2, CDKN1A, CCND1, TP53
14p00001448.9CCND1, MKI67, S100A8, CDKN2A
15acyclic retinoid448.9CCND1, EGFR, CDKN1A, TGFA
16crcs448.8TP53, CDKN2A, S100A8, CCND1
17suberoylanilide hydroxamic acid448.8BCL2, TP53, CCND1, CDKN1A, EGFR
18adriamycin448.8CDKN1A, BCL2, CCND1, CDKN2A, TP53
19bortezomib44 119.7BCL2, CDKN1A, EGFR, CCND1, TP53
20irinotecan44 49 1110.7MKI67, CDKN2A, CDKN1A, TP53, EGFR
21adpribose448.7CCND1, CDKN1A, BCL2, TP53, EGFR
22flavopiridol44 119.5CDKN2A, EGFR, CDKN1A, CCND1, BCL2, TP53
23docetaxel44 49 59 1111.5EGFR, CDKN2A, CDKN1A, BCL2, TP53
24gemcitabine44 49 1110.5TP53, BCL2, PTGS2, CDKN1A, EGFR, CCND1
25n-(4-hydroxyphenyl)retinamide448.5TGFA, TP53, BCL2, CDKN1A, CCND1
26mg 13244 599.5BCL2, CDKN1A, CDKN2A, EGFR, CCND1, TP53
27celecoxib44 59 28 49 11 2413.4MKI67, EGFR, CCND1, CDKN1A, PTGS2, BCL2
28gefitinib44 49 1110.4CCND1, TGFA, PTGS2, CDKN1A, EGFR
29curcumin448.4PTGS2, TP53, CCND1, BCL2, EGFR, CDKN1A
30sb 20358044 599.3BCL2, CDKN1A, TP53, CCND1, EGFR, PTGS2
31gf 109203x44 599.3EGFR, CCND1, TGFA, PTGS2, CDKN1A
32n acetylcysteine448.2TP53, BCL2, PTGS2, CDKN1A, CDKN2A, EGFR
33retinoid448.1TP53, BCL2, CDKN1A, S100A8, EGFR, CCND1
34thymidylate448.0TP53, MKI67, EGFR, CCND1, CDKN1A, CDKN2A
35methotrexate44 49 119.9SI, CDKN2A, MKI67, TGFA, S100A8, CCND1
36genistein44 28 59 2 11 2412.7CDKN1A, CDKN2A, PTGS2, BCL2, TGFA, EGFR
37paclitaxel44 49 119.7CDKN1A, TGFA, CDKN2A, TP53, CCND1, BCL2
38pd 98,059447.7CCND1, PTGS2, CDKN1A, EGFR, BCL2, TGFA
39agar447.7SI, TGFA, CDKN1A, CDKN2A, EGFR, S100A8
40actinomycin d447.6PTGS2, CDKN2A, CDKN1A, BCL2, TGFA, TP53
41cisplatin44 49 59 1110.6EGFR, CCND1, PTGS2, MKI67, CDKN2A, CDKN1A
42ly294002447.6CCND1, EGFR, PTGS2, BCL2, TP53, TGFA
43tamoxifen44 49 28 1110.5EGFR, MKI67, BCL2, TP53, TGFA, CDKN1A
445fluorouracil447.5CDKN1A, CDKN2A, MKI67, EGFR, TGFA, BCL2
45paraffin447.4SI, TGFA, BCL2, CDKN1A, MKI67, EGFR
46doxorubicin44 49 119.2TGFA, EGFR, CCND1, BCL2, MKI67, CDKN2A
47progesterone44 59 28 11 2411.1EGFR, TGFA, TP53, CDKN1A, CCND1, BCL2
48oligonucleotide446.9CCND1, S100A8, TGFA, TP53, BCL2, CDKN1A
49vegf446.8CCND1, TGFA, TP53, BCL2, PTGS2, CDKN1A
50retinoic acid44 247.5TP53, BCL2, CDKN1A, CDKN2A, EGFR, MKI67

GO Terms for genes affiliated with Esophagus Adenocarcinoma

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16Gene Ontology
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Cellular components related to Esophagus Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003079.5CDKN1A, CCND1
2nucleusGO:0056346.4EGFR, MKI67, CDKN2A, CDKN1A, PTGS2, BCL2

Biological processes related to Esophagus Adenocarcinoma according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1response to iron ionGO:01003910.0CCND1, BCL2
2response to organonitrogen compoundGO:01024310.0CDKN1A, CCND1
3mitotic G1 DNA damage checkpointGO:03157110.0TP53, CCND1
4response to UV-AGO:07014110.0EGFR, CCND1
5replicative senescenceGO:09039910.0CDKN2A, TP53
6mitotic cell cycle arrestGO:07185010.0TP53, CDKN1A
7B cell lineage commitmentGO:0023269.9BCL2, TP53
8response to corticosterone stimulusGO:0514129.9CCND1, CDKN1A
9regulation of mitochondrial membrane permeabilityGO:0469029.9TP53, BCL2
10positive regulation of cell cycle arrestGO:0711589.8TP53, CDKN2A
11response to X-rayGO:0101659.8CCND1, TP53
12negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.8CDKN1A, CDKN2A
13digestive tract morphogenesisGO:0485469.7BCL2, EGFR
14cellular senescenceGO:0903989.7CDKN2A, CDKN1A
15Ras protein signal transductionGO:0072659.7TP53, CDKN1A, CDKN2A
16organ regenerationGO:0311009.6CCND1, MKI67, CDKN1A
17release of cytochrome c from mitochondriaGO:0018369.6TP53, BCL2
18intrinsic apoptotic signaling pathwayGO:0971939.6TP53, BCL2, CDKN1A
19mammary gland alveolus developmentGO:0607499.6TGFA, CCND1
20cell cycle arrestGO:0070509.5CDKN2A, CDKN1A, TP53
21negative regulation of phosphorylationGO:0423269.5CDKN2A, CDKN1A
22positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.4S100A8, BCL2, TP53
23response to DNA damage stimulusGO:0069749.3TP53, BCL2, CDKN1A, CCND1
24negative regulation of cell growthGO:0303089.3CDKN2A, CDKN1A, BCL2, TP53
25negative regulation of cell proliferationGO:0082859.2CDKN2A, CDKN1A, PTGS2, TP53
26response to drugGO:0424938.6TGFA, BCL2, PTGS2, CDKN1A, CCND1
27cell proliferationGO:0082838.5EGFR, MKI67, TP53, TGFA
28negative regulation of apoptotic processGO:0430668.2EGFR, CDKN1A, BCL2, TP53, TGFA

Molecular functions related to Esophagus Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.7CDKN2A, TP53
2protein phosphatase 2A bindingGO:0517219.6TP53, BCL2
3cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.5CDKN1A, CDKN2A
4enzyme bindingGO:0198998.9TP53, PTGS2, EGFR, CCND1
5protein bindingGO:0055155.8CCND1, S100A8, EGFR, MTMR9, MKI67, CDKN2A

Products for genes affiliated with Esophagus Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
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51QIAGEN
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60UMLS
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