MCID: ESP027
MIFTS: 39

Esophagus Squamous Cell Carcinoma malady

Cancer diseases category

Summaries for Esophagus Squamous Cell Carcinoma

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A sarcoma that begins in flat cells lining the esophagus.

MalaCards: Esophagus Squamous Cell Carcinoma, also known as squamous cell carcinoma of esophagus, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Esophagus Squamous Cell Carcinoma is RUNX3 (runt-related transcription factor 3), and among its related pathways are Hippo signaling pathway and Presenilin-Mediated Signaling. The compounds dihydrotestosterone and b 723 have been mentioned in the context of this disorder. Affiliated tissues include endothelial, lymph node and lung.

Description from OMIM:46 133239

Aliases & Classifications for Esophagus Squamous Cell Carcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 46OMIM, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

esophagus squamous cell carcinoma 8 10
squamous cell carcinoma of esophagus 8 60
scc of esophagus 8


External Ids:

Disease Ontology8 DOID:3748
OMIM46 133239
SNOMED-CT56 276804009
NCIt39 C4024

Related Diseases for Esophagus Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Esophagus Squamous Cell Carcinoma:



Diseases related to esophagus squamous cell carcinoma

Clinical Features for Esophagus Squamous Cell Carcinoma

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46OMIM
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Clinical features from OMIM:

133239

Drugs & Therapeutics for Esophagus Squamous Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Esophagus Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Esophagus Squamous Cell Carcinoma

Search NIH Clinical Center for Esophagus Squamous Cell Carcinoma

Search CenterWatch for Esophagus Squamous Cell Carcinoma

Genetic Tests for Esophagus Squamous Cell Carcinoma

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Anatomical Context for Esophagus Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Esophagus Squamous Cell Carcinoma:

32
Endothelial, Lymph node, Lung

Animal Models for Esophagus Squamous Cell Carcinoma or affiliated genes

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Publications for Esophagus Squamous Cell Carcinoma

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50PubMed
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Articles related to Esophagus Squamous Cell Carcinoma:

(show top 50)    (show all 168)
idTitleAuthorsYear
1
Pretreatment metabolic tumor volumes to predict the short-term outcome of unresectable locally advanced squamous cell carcinoma of the esophagus treated with definitive chemoradiotherapy. (24276528)
2013
2
Erratum to: Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus. (24141378)
2013
3
Esophageal squamous cell carcinoma arising after endoscopic ablation therapy of Barrett's esophagus with high-grade dysplasia. Report of a case. (23009180)
2013
4
Role of postoperative radiotherapy for microscopic margin involvement in the squamous cell carcinoma of esophagus. (24155679)
2013
5
Clinical outcomes of basaloid squamous cell carcinoma of the esophagus: a retrospective analysis of 142 cases. (23679289)
2013
6
Downregulation of tropomyosin-1 in squamous cell carcinoma of esophagus, the role of Ras signaling and methylation. (22965424)
2012
7
Common genomic aberrations in basaloid squamous cell carcinoma and carcinosarcoma of the esophagus detected by CGH and array CGH. (21411780)
2011
8
Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development. (19732125)
2010
9
Two coincident squamous cell carcinomas of the esophagus in a patient with achalasia: evidence by F-18 FDG PET/CT. (20631527)
2010
10
Adipocytokines and squamous cell carcinoma of the esophagus. (19693538)
2010
11
Aberrant promoter CpG island hypermethylation of the adenomatosis polyposis coli gene can serve as a good prognostic factor by affecting lymph node metastasis in squamous cell carcinoma of the esophagus. (18847451)
2009
12
Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. (18033686)
2008
13
Validation of tissue microarray technology in squamous cell carcinoma of the esophagus. (18392848)
2008
14
Expression of p53 and p21 and the clinical response for hyperthermochemoradiotherapy in patients with squamous cell carcinoma of the esophagus. (17972508)
2007
15
Oral health and risk of squamous cell carcinoma of the head and neck and esophagus: results of two multicentric case-control studies. (17761691)
2007
16
Ep-CAM expression in squamous cell carcinoma of the esophagus: a potential therapeutic target and prognostic marker. (16796747)
2006
17
Choriocarcinoma - a rare association with squamous cell carcinoma of esophagus. (16567899)
2006
18
Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus. (16647955)
2006
19
Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus. (16094634)
2006
20
Alteration of RPL14 in squamous cell carcinomas and preneoplastic lesions of the esophagus. (16316724)
2006
21
Expression of deltaNp63 in squamous cell carcinoma of the esophagus. (16101176)
2005
22
Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. (15856454)
2005
23
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus. (16270380)
2005
24
Role of retinoic acid receptors in squamous-cell carcinoma in human esophagus. (16277658)
2005
25
Reduced tumor vessel density and high expression of glucose transporter 1 suggest tumor hypoxia of squamous cell carcinoma of the esophagus surviving after radiotherapy. (15855926)
2005
26
DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage. (16128742)
2005
27
Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features. (15387711)
2004
28
Telomerase activity and expression of telomerase genes in squamous dysplasia and squamous cell carcinoma of the esophagus. (15112252)
2004
29
Helicobacter pylori infection and gastric atrophy: risk of adenocarcinoma and squamous-cell carcinoma of the esophagus and adenocarcinoma of the gastric cardia. (14996860)
2004
30
Immunohistochemical expression of C-reactive protein in squamous cell carcinoma of the esophagus - significance as a tumor marker. (12637157)
2003
31
Prognostic value of p53 protein expression and vascular endothelial growth factor expression in resected squamous cell carcinoma of the esophagus. (12823209)
2003
32
Humoral hypercalcemia of malignancy due to bipartite squamous cell/small cell carcinoma of the esophagus immunoreactive for parathyroid hormone related protein. (14641300)
2003
33
MDM2 and CDK4 expression in carcinosarcoma of the esophagus: comparison with squamous cell carcinoma and review of the literature. (12565795)
2002
34
Expression of G1 cell cycle markers and the effect of adenovirus-mediated overexpression of p21Waf-1 in squamous cell carcinoma of the esophagus. (11115554)
2001
35
SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus. (11511096)
2001
36
The role of cyclin-dependent kinase inhibitor p27 in squamous cell carcinoma of the esophagus. (11314778)
2001
37
An immunohistochemical examination of basaloid squamous cell carcinoma of the esophagus: report of a case. (11495163)
2001
38
Tumor angiogenesis as an independent prognostic factor after extended radical esophagectomy for invasive squamous cell carcinoma of the esophagus. (11231458)
2001
39
Prognostic significance of biologic factors in squamous cell carcinoma of the esophagus. (10526265)
1999
40
Prognostic significance of heat shock proteins 27 and 70 in patients with squamous cell carcinoma of the esophagus. (10223556)
1999
41
Association between genetic polymorphisms of glutathione S-transferase P1 and N-acetyltransferase 2 and susceptibility to squamous-cell carcinoma of the esophagus. (9761122)
1998
42
Expression of p53 protein in glandular differentiation admixed with squamous cell carcinoma of the esophagus. (9058139)
1997
43
Prognostic significance of urokinase-type plasminogen activator expression in squamous cell carcinomas of the esophagus. (9815623)
1997
44
High frequency of simultaneous loss of p16 and p16beta gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach. (9333024)
1997
45
Prognostic significance of proliferating cell nuclear antigen (PCNA) in squamous cell carcinoma of the esophagus. (9001344)
1996
46
Cyclin D1 amplification as a new predictive classification for squamous cell carcinoma of the esophagus, adding gene information. (9816282)
1996
47
Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. (7742727)
1995
48
Human papillomavirus DNA sequences in esophagus squamous cell carcinoma. (7912679)
1994
49
Tumor markers in squamous cell carcinoma of esophagus: immunometric assay in cytosol and membrane fraction. (2230354)
1990
50
Squamous cell carcinoma of the esophagus in Fanconi's anemia. (3251695)
1988

Genetic Variations for Esophagus Squamous Cell Carcinoma

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Expression for genes affiliated with Esophagus Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophagus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophagus Squamous Cell Carcinoma.

Pathways for genes affiliated with Esophagus Squamous Cell Carcinoma

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29KEGG, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BTRC, CDH1, TGFB1
29.5NOTCH1, CDH1, BTRC
3
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9.2TGFB1, CDH1, BTRC, VIM
49.2NOTCH1, RAB11A, BTRC

Compounds for genes affiliated with Esophagus Squamous Cell Carcinoma

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1dihydrotestosterone44 28 11 2413.0VIM, TGFB1
2b 723449.9CDH1, VIM
3aristolochic acid44 210.8TGFB1, CDH1, VIM
4cytochalasin d44 5910.7VIM, CDH1, TGFB1
5tgf beta1449.6TGFB1, CDH1, VIM
6hyaluronic acid44 2410.6VIM, CDH1, TGFB1
7formaldehyde44 2410.5TGFB1, CDH1, VIM
85-aza-2deoxycytidine449.5VIM, RUNX3, CDH1
9glycogen44 2410.4NOTCH1, CDH1, BTRC, VIM
10matrigel449.4TGFB1, NOTCH1, CDH1, VIM
11doxorubicin44 49 1111.4VIM, CDH1, NOTCH1, TGFB1
12methotrexate44 49 1111.2TGFB1, CDH1, VIM
13vegf449.1VIM, RUNX3, CDH1, NOTCH1, TGFB1
14retinoic acid44 2410.0TGFB1, NOTCH1, CDH1, RUNX3, VIM
15serine448.8VIM, RUNX3, BTRC, CDH1, NOTCH1, TGFB1

GO Terms for genes affiliated with Esophagus Squamous Cell Carcinoma

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16Gene Ontology
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Biological processes related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-cell adhesionGO:02240810.0CDH1, TGFB1
2negative regulation of myoblast differentiationGO:04566210.0TGFB1, NOTCH1
3negative regulation of ossificationGO:0302799.9TGFB1, NOTCH1
4positive regulation of epithelial to mesenchymal transitionGO:0107189.9TGFB1, NOTCH1
5cellular response to organic cyclic compoundGO:0714079.8BTRC, TGFB1
6endoderm developmentGO:0074929.8TGFB1, NOTCH1
7epithelial to mesenchymal transitionGO:0018379.8TGFB1, NOTCH1
8hair follicle morphogenesisGO:0310699.7RUNX3, NOTCH1
9chondrocyte differentiationGO:0020629.6TGFB1, RUNX3
10positive regulation of transcription, DNA-dependentGO:0458939.3BTRC, CDH1, NOTCH1, TGFB1
11viral life cycleGO:0190589.0TGFB1, RPL7, RPL28

Molecular functions related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.6TGFB1, NOTCH1, RAB11A, CDH1, BTRC, RUNX3

Products for genes affiliated with Esophagus Squamous Cell Carcinoma

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  • Antibodies
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Sources for Esophagus Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet