MCID: ESP027
MIFTS: 41

Esophagus Squamous Cell Carcinoma malady

Cancer diseases, Gastrointestinal diseases categories
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Summaries for Esophagus Squamous Cell Carcinoma

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Disease Ontology:8 An esophageal carcinoma that derives from epithelial squamous cells located in the esophagus.

MalaCards based summary: Esophagus Squamous Cell Carcinoma, also known as squamous cell carcinoma of esophagus, is related to adenocarcinoma and choriocarcinoma. An important gene associated with Esophagus Squamous Cell Carcinoma is DSE (dermatan sulfate epimerase), and among its related pathways are Apoptotic cleavage of cellular proteins and TGF Beta Signaling Pathway. The compounds b 723 and acetaldehyde have been mentioned in the context of this disorder. Affiliated tissues include the esophagus and lymph node, and related mouse phenotypes are integument and growth/size/body.

Description from OMIM:46 133239

Aliases & Classifications for Esophagus Squamous Cell Carcinoma

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Esophagus Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Esophagus Squamous Cell Carcinoma 8 10
Squamous Cell Carcinoma of Esophagus 8 62
 
Scc of Esophagus 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


External Ids:

Disease Ontology8 DOID:3748
OMIM46 133239
SNOMED-CT57 276804009
NCIt39 C4024

Related Diseases for Esophagus Squamous Cell Carcinoma

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Graphical network of the top 20 diseases related to Esophagus Squamous Cell Carcinoma:



Diseases related to esophagus squamous cell carcinoma

Symptoms for Esophagus Squamous Cell Carcinoma

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Clinical features from OMIM:

133239

Drugs & Therapeutics for Esophagus Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Esophagus Squamous Cell Carcinoma

Search NIH Clinical Center for Esophagus Squamous Cell Carcinoma

Genetic Tests for Esophagus Squamous Cell Carcinoma

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Anatomical Context for Esophagus Squamous Cell Carcinoma

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MalaCards organs/tissues related to Esophagus Squamous Cell Carcinoma:

32
Lymph node

FMA organs/tissues related to Esophagus Squamous Cell Carcinoma:

14
The esophagus

Animal Models for Esophagus Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Esophagus Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5CDH1, NOTCH1, DSE, TGFB1, RUNX3
2MP:00053788.4TGFB1, DSE, VIM, NOTCH1, CDH1, RUNX3

Publications for Esophagus Squamous Cell Carcinoma

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Articles related to Esophagus Squamous Cell Carcinoma:

idTitleAuthorsYear
1
Human papillomavirus types 16 and 18 in esophagus squamous cell carcinoma: a meta-analysis. (23916383)
2013
2
Notch1 is a 5-fluorouracil resistant and poor survival marker in human esophagus squamous cell carcinomas. (23409141)
2013
3
Prognostic Value of Tumor-Infiltrating Mast Cells in Outcome of Patients with Esophagus Squamous Cell Carcinoma. (24091743)
2013
4
Prediagnostic smoking and postoperative survival in lymph node-negative esophagus squamous cell carcinoma patients. (22913634)
2012
5
Retrospective study of gemcitabine based chemotherapy for unresectable or recurrent esophagus squamous cell carcinoma refractory to first line chemotherapy. (23098537)
2012
6
Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. (22350411)
2012
7
Analysis of the RUNX3 gene methylation in serum DNA from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients. (22234069)
2011
8
Transforming growth factor beta1 regulation of epithelial-mesenchymal transition in esophagus squamous cell carcinoma]. (19094466)
2008
9
Human papillomavirus DNA sequences in esophagus squamous cell carcinoma. (7912679)
1994

Variations for Esophagus Squamous Cell Carcinoma

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Expression for genes affiliated with Esophagus Squamous Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Esophagus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophagus Squamous Cell Carcinoma.

Pathways for genes affiliated with Esophagus Squamous Cell Carcinoma

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Pathways related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CDH1, VIM
29.8TGFB1, RUNX3
39.8TGFB1, RUNX3
49.8TGFB1, RUNX3
59.7NOTCH1, TGFB1
6
Show member pathways
Notch signaling pathway37
9.5RAB11A, NOTCH1
79.2VIM, RAB11A, CDH1
8
Show member pathways
9.1TGFB1, RAB11A, CDH1
9
Show member pathways
9.0CDH1, NOTCH1, VIM, TGFB1
10
Show member pathways
8.7RPL28, RPL7, TGFB1
118.1NOTCH1, RPL28, RPL7, DSE, TGFB1

Compounds for genes affiliated with Esophagus Squamous Cell Carcinoma

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Compounds related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1b 7234410.1VIM, CDH1
2acetaldehyde28 44 2411.9CDH1, VIM
3methylcellulose449.9CDH1, TGFB1
45-aza-2deoxycytidine449.9RUNX3, VIM, CDH1
5aristolochic acid44 210.8CDH1, VIM, TGFB1
6cytochalasin d44 6110.8TGFB1, VIM, CDH1
7streptozotocin449.8TGFB1, VIM
8dihydrotestosterone44 28 24 1112.8CDH1, VIM, TGFB1
9tgf beta1449.8TGFB1, VIM, CDH1
10hyaluronic acid44 2410.8CDH1, VIM, TGFB1
11formaldehyde44 2410.8CDH1, VIM, TGFB1
12methotrexate50 44 1111.8CDH1, VIM, TGFB1
13etoposide44 50 61 1112.7CDH1, VIM, TGFB1
14indomethacin44 28 61 1112.7CDH1, VIM, TGFB1
1512-o-tetradecanoylphorbol 13-acetate449.7CDH1, VIM, TGFB1
16sb 20358044 6110.7TGFB1, VIM, CDH1
17butyrate449.7CDH1, VIM, TGFB1
18tamoxifen44 50 28 1112.7TGFB1, VIM, CDH1
19vitamin d449.7CDH1, VIM, TGFB1
20rapamycin449.7CDH1, NOTCH1, VIM
21paclitaxel44 50 1111.7CDH1, VIM, TGFB1
22histamine44 28 2411.7TGFB1, VIM, CDH1
23glycogen44 2410.6VIM, NOTCH1, CDH1
24ly294002449.6CDH1, NOTCH1, TGFB1
25matrigel449.4CDH1, NOTCH1, VIM, TGFB1
26doxorubicin44 50 1111.4TGFB1, VIM, NOTCH1, CDH1
27paraffin449.4CDH1, VIM, TGFB1
28glutamine449.4CDH1, VIM, TGFB1
29dexamethasone44 50 28 1112.4TGFB1, VIM, NOTCH1, CDH1
30genistein44 28 61 2 24 1114.3VIM, NOTCH1, CDH1
31estrogen449.2TGFB1, VIM, NOTCH1, CDH1
32proline449.1CDH1, NOTCH1, VIM
33vegf449.1RUNX3, TGFB1, VIM, NOTCH1, CDH1
34retinoic acid44 2410.1CDH1, NOTCH1, VIM, TGFB1, RUNX3
35serine449.1RUNX3, TGFB1, VIM, NOTCH1, CDH1

GO Terms for genes affiliated with Esophagus Squamous Cell Carcinoma

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Cellular components related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.4CDH1, NOTCH1, TGFB1
2cytosolic large ribosomal subunitGO:0226258.8RPL28, RPL7

Biological processes related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-cell adhesionGO:02240810.0TGFB1, CDH1
2hair follicle morphogenesisGO:03106910.0RUNX3, NOTCH1
3negative regulation of myoblast differentiationGO:04566210.0NOTCH1, TGFB1
4negative regulation of ossificationGO:0302799.9NOTCH1, TGFB1
5endoderm developmentGO:0074929.9NOTCH1, TGFB1
6positive regulation of epithelial to mesenchymal transitionGO:0107189.9NOTCH1, TGFB1
7chondrocyte differentiationGO:0020629.9TGFB1, RUNX3
8epithelial to mesenchymal transitionGO:0018379.8NOTCH1, TGFB1
9negative regulation of cell cycleGO:0457869.8RUNX3, TGFB1
10cell-cell junction organizationGO:0452169.7CDH1, TGFB1
11negative regulation of epithelial cell proliferationGO:0506809.7CDH1, TGFB1, RUNX3
12cellular component disassembly involved in execution phase of apoptosisGO:0069219.7CDH1, VIM
13protein localization to plasma membraneGO:0726599.6CDH1, RAB11A
14positive regulation of epithelial cell proliferationGO:0506799.4NOTCH1, TGFB1
15viral life cycleGO:0190589.0RPL28, RPL7, TGFB1

Molecular functions related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.8CDH1, VIM
2protein bindingGO:0055156.5CDH1, RUNX3, TGFB1, VIM, RPL7, RPL28

Products for genes affiliated with Esophagus Squamous Cell Carcinoma

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  • Antibodies
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Sources for Esophagus Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet