MCID: ESP027
MIFTS: 39

Esophagus Squamous Cell Carcinoma malady

Cancer diseases category

Summaries for Esophagus Squamous Cell Carcinoma

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Sources:
9Disease Ontology, 48OMIM, 34MalaCards
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Disease Ontology:9 A sarcoma that begins in flat cells lining the esophagus.

MalaCards: Esophagus Squamous Cell Carcinoma, also known as squamous cell carcinoma of esophagus, is related to adenocarcinoma and choriocarcinoma. An important gene associated with Esophagus Squamous Cell Carcinoma is DSE (dermatan sulfate epimerase), and among its related pathways are Apoptotic cleavage of cellular proteins and TGF Beta Signaling Pathway. The compounds b 723 and acetaldehyde have been mentioned in the context of this disorder. Affiliated tissues include lymph node, and related mouse phenotypes are integument and growth/size/body.

Description from OMIM:48 133239

Aliases & Classifications for Esophagus Squamous Cell Carcinoma

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 41NCIt, 59SNOMED-CT, 48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

esophagus squamous cell carcinoma 9 11
squamous cell carcinoma of esophagus 9 63
scc of esophagus 9


External Ids:

Disease Ontology9 DOID:3748
NCIt41 C4024
SNOMED-CT59 276804009
OMIM48 133239

Related Diseases for Esophagus Squamous Cell Carcinoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Esophagus Squamous Cell Carcinoma:



Diseases related to esophagus squamous cell carcinoma

Symptoms for Esophagus Squamous Cell Carcinoma

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48OMIM
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Clinical features from OMIM:

133239

Drugs & Therapeutics for Esophagus Squamous Cell Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Esophagus Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Esophagus Squamous Cell Carcinoma

Search NIH Clinical Center for Esophagus Squamous Cell Carcinoma

Search CenterWatch for Esophagus Squamous Cell Carcinoma

Genetic Tests for Esophagus Squamous Cell Carcinoma

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Anatomical Context for Esophagus Squamous Cell Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Esophagus Squamous Cell Carcinoma:

34
Lymph node

Animal Models for Esophagus Squamous Cell Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Esophagus Squamous Cell Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.5CDH1, NOTCH1, DSE, TGFB1, RUNX3
2MP:00053788.4TGFB1, DSE, VIM, NOTCH1, CDH1, RUNX3

Publications for Esophagus Squamous Cell Carcinoma

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53PubMed
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Articles related to Esophagus Squamous Cell Carcinoma:

idTitleAuthorsYear
1
Human papillomavirus types 16 and 18 in esophagus squamous cell carcinoma: a meta-analysis. (23916383)
2013
2
Notch1 is a 5-fluorouracil resistant and poor survival marker in human esophagus squamous cell carcinomas. (23409141)
2013
3
Prognostic Value of Tumor-Infiltrating Mast Cells in Outcome of Patients with Esophagus Squamous Cell Carcinoma. (24091743)
2013
4
Prediagnostic smoking and postoperative survival in lymph node-negative esophagus squamous cell carcinoma patients. (22913634)
2012
5
Retrospective study of gemcitabine based chemotherapy for unresectable or recurrent esophagus squamous cell carcinoma refractory to first line chemotherapy. (23098537)
2012
6
Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. (22350411)
2012
7
Analysis of the RUNX3 gene methylation in serum DNA from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients. (22234069)
2011
8
Transforming growth factor beta1 regulation of epithelial-mesenchymal transition in esophagus squamous cell carcinoma]. (19094466)
2008
9
Human papillomavirus DNA sequences in esophagus squamous cell carcinoma. (7912679)
1994

Variations for Esophagus Squamous Cell Carcinoma

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Expression for genes affiliated with Esophagus Squamous Cell Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophagus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophagus Squamous Cell Carcinoma.

Pathways for genes affiliated with Esophagus Squamous Cell Carcinoma

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 5Cell Signaling Technology, 31KEGG, 54QIAGEN
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Pathways related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CDH1, VIM
29.8TGFB1, RUNX3
39.8TGFB1, RUNX3
49.8TGFB1, RUNX3
59.7NOTCH1, TGFB1
6
Show member pathways
Notch signaling pathway39
9.5RAB11A, NOTCH1
79.2VIM, RAB11A, CDH1
8
Show member pathways
9.1TGFB1, RAB11A, CDH1
9
Show member pathways
9.0CDH1, NOTCH1, VIM, TGFB1
10
Show member pathways
8.7RPL28, RPL7, TGFB1
118.1NOTCH1, RPL28, RPL7, DSE, TGFB1

Compounds for genes affiliated with Esophagus Squamous Cell Carcinoma

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 3BitterDB, 62Tocris Bioscience, 12DrugBank, 52PharmGKB
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Compounds related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1b 7234610.1VIM, CDH1
2acetaldehyde30 46 2511.9CDH1, VIM
3methylcellulose469.9CDH1, TGFB1
45-aza-2deoxycytidine469.9RUNX3, VIM, CDH1
5aristolochic acid46 310.8CDH1, VIM, TGFB1
6cytochalasin d46 6210.8TGFB1, VIM, CDH1
7streptozotocin469.8TGFB1, VIM
8dihydrotestosterone46 30 25 1212.8CDH1, VIM, TGFB1
9tgf beta1469.8TGFB1, VIM, CDH1
10hyaluronic acid46 2510.8CDH1, VIM, TGFB1
11formaldehyde46 2510.8CDH1, VIM, TGFB1
12methotrexate52 46 1211.8CDH1, VIM, TGFB1
13etoposide46 52 62 1212.7CDH1, VIM, TGFB1
14indomethacin46 30 62 1212.7CDH1, VIM, TGFB1
1512-o-tetradecanoylphorbol 13-acetate469.7CDH1, VIM, TGFB1
16sb 20358046 6210.7TGFB1, VIM, CDH1
17butyrate469.7CDH1, VIM, TGFB1
18tamoxifen46 52 30 1212.7TGFB1, VIM, CDH1
19vitamin d469.7CDH1, VIM, TGFB1
20rapamycin469.7CDH1, NOTCH1, VIM
21paclitaxel46 52 1211.7CDH1, VIM, TGFB1
22histamine46 30 2511.7TGFB1, VIM, CDH1
23glycogen46 2510.6VIM, NOTCH1, CDH1
24ly294002469.6CDH1, NOTCH1, TGFB1
25matrigel469.4CDH1, NOTCH1, VIM, TGFB1
26doxorubicin46 52 1211.4TGFB1, VIM, NOTCH1, CDH1
27paraffin469.4CDH1, VIM, TGFB1
28glutamine469.4CDH1, VIM, TGFB1
29dexamethasone46 52 30 1212.4TGFB1, VIM, NOTCH1, CDH1
30genistein46 30 62 3 25 1214.3VIM, NOTCH1, CDH1
31estrogen469.2TGFB1, VIM, NOTCH1, CDH1
32proline469.1CDH1, NOTCH1, VIM
33vegf469.1RUNX3, TGFB1, VIM, NOTCH1, CDH1
34retinoic acid46 2510.1CDH1, NOTCH1, VIM, TGFB1, RUNX3
35serine469.1RUNX3, TGFB1, VIM, NOTCH1, CDH1

GO Terms for genes affiliated with Esophagus Squamous Cell Carcinoma

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Sources:
17Gene Ontology
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Cellular components related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.4CDH1, NOTCH1, TGFB1
2cytosolic large ribosomal subunitGO:0226258.8RPL28, RPL7

Biological processes related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-cell adhesionGO:02240810.0TGFB1, CDH1
2hair follicle morphogenesisGO:03106910.0RUNX3, NOTCH1
3negative regulation of myoblast differentiationGO:04566210.0NOTCH1, TGFB1
4negative regulation of ossificationGO:0302799.9NOTCH1, TGFB1
5endoderm developmentGO:0074929.9NOTCH1, TGFB1
6positive regulation of epithelial to mesenchymal transitionGO:0107189.9NOTCH1, TGFB1
7chondrocyte differentiationGO:0020629.9TGFB1, RUNX3
8epithelial to mesenchymal transitionGO:0018379.8NOTCH1, TGFB1
9negative regulation of cell cycleGO:0457869.8RUNX3, TGFB1
10cell-cell junction organizationGO:0452169.7CDH1, TGFB1
11negative regulation of epithelial cell proliferationGO:0506809.7CDH1, TGFB1, RUNX3
12cellular component disassembly involved in execution phase of apoptosisGO:0069219.7CDH1, VIM
13protein localization to plasma membraneGO:0726599.6CDH1, RAB11A
14positive regulation of epithelial cell proliferationGO:0506799.4NOTCH1, TGFB1
15viral life cycleGO:0190589.0RPL28, RPL7, TGFB1

Molecular functions related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.8CDH1, VIM
2protein bindingGO:0055156.5CDH1, RUNX3, TGFB1, VIM, RPL7, RPL28

Products for genes affiliated with Esophagus Squamous Cell Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophagus Squamous Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet