MCID: ESP027
MIFTS: 39

Esophagus Squamous Cell Carcinoma malady

Cancer diseases category

Summaries for Esophagus Squamous Cell Carcinoma

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A sarcoma that begins in flat cells lining the esophagus.

MalaCards: Esophagus Squamous Cell Carcinoma, also known as squamous cell carcinoma of esophagus, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Esophagus Squamous Cell Carcinoma is RUNX3 (runt-related transcription factor 3), and among its related pathways are Hippo signaling pathway and Presenilin-Mediated Signaling. The compounds dihydrotestosterone and b 723 have been mentioned in the context of this disorder. Affiliated tissues include endothelial, lymph node and lung.

Description from OMIM:46 133239

Aliases & Classifications for Esophagus Squamous Cell Carcinoma

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8Disease Ontology, 10DISEASES, 60UMLS, 46OMIM, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

esophagus squamous cell carcinoma 8 10
squamous cell carcinoma of esophagus 8 60
scc of esophagus 8


External Ids:

Disease Ontology8 DOID:3748
OMIM46 133239
SNOMED-CT56 276804009
NCIt39 C4024

Related Diseases for Esophagus Squamous Cell Carcinoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Esophagus Squamous Cell Carcinoma:



Diseases related to esophagus squamous cell carcinoma

Clinical Features for Esophagus Squamous Cell Carcinoma

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46OMIM
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Clinical features from OMIM:

133239

Drugs & Therapeutics for Esophagus Squamous Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Esophagus Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Esophagus Squamous Cell Carcinoma

Search NIH Clinical Center for Esophagus Squamous Cell Carcinoma

Search CenterWatch for Esophagus Squamous Cell Carcinoma

Genetic Tests for Esophagus Squamous Cell Carcinoma

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Anatomical Context for Esophagus Squamous Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Esophagus Squamous Cell Carcinoma:

32
Endothelial, Lymph node, Lung

Animal Models for Esophagus Squamous Cell Carcinoma or affiliated genes

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Publications for Esophagus Squamous Cell Carcinoma

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50PubMed
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Articles related to Esophagus Squamous Cell Carcinoma:

(show top 50)    (show all 168)
idTitleAuthorsYear
1
Reduced expression of DENND2D through promoter hypermethylation is an adverse prognostic factor in squamous cell carcinoma of the esophagus. (24317529)
2014
2
Clinical significance of combined detection of human papilloma virus infection and human telomerase RNA component gene amplification in patients with squamous cell carcinoma of the esophagus in northern China. (23634750)
2013
3
A rare collision tumor of squamous carcinoma and small cell carcinoma in esophagus involved with separate lymph nodes: a case report. (24255793)
2013
4
Novel drug discovery system for cancer stem cells in human squamous cell carcinoma of the esophagus. (24378718)
2013
5
T1 Squamous Cell Carcinoma of the Esophagus: Long-Term Outcomes and Prognostic Factors After Esophagectomy. (24232603)
2013
6
Human papillomavirus types 16 and 18 in esophagus squamous cell carcinoma: a meta-analysis. (23916383)
2013
7
Prediagnostic smoking and postoperative survival in lymph node-negative esophagus squamous cell carcinoma patients. (22913634)
2012
8
Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia. (23244191)
2012
9
Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. (22350411)
2012
10
MDM2 is overexpressed and regulated by the eukaryotic translation initiation factor 4E (eIF4E) in human squamous cell carcinoma of esophagus. (21080085)
2011
11
Aberrant expression of EZH2 is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the esophagus. (21165554)
2011
12
Verrucous carcinoma of the esophagus: a rare variant of squamous cell carcinoma for which a preoperative diagnosis can be a difficult one to make. (22272545)
2011
13
Histological diversity in basaloid squamous cell carcinoma of the esophagus. (18847449)
2009
14
High orotate phosphoribosyltransferase gene expression predicts complete response to chemoradiotherapy in patients with squamous cell carcinoma of the esophagus. (19307741)
2009
15
Reduced axin protein expression is associated with a poor prognosis in patients with squamous cell carcinoma of esophagus. (19582507)
2009
16
Transforming growth factor beta1 regulation of epithelial-mesenchymal transition in esophagus squamous cell carcinoma]. (19094466)
2008
17
Expression of cytokeratin 7 predicts survival in stage I/IIA/IIB squamous cell carcinoma of the esophagus. (18949396)
2008
18
Seprase, dipeptidyl peptidase IV and urokinase-type plasminogen activator expression in dysplasia and invasive squamous cell carcinoma of the esophagus. A study of 229 cases from Anyang Tumor Hospital, Henan Province, China. (18787344)
2008
19
pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus. (17461478)
2007
20
Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin. (17659717)
2007
21
Value of CK14 and CD56 immunostaining in distinguishing small cell carcinoma from squamous cell carcinoma of the esophagus. (17017394)
2006
22
The expression pattern of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetyl-galactosaminyl transferase-3 in squamous cell carcinoma of the esophagus. (15860931)
2005
23
Basaloid squamous cell carcinoma of the esophagus: a case report. (15850013)
2005
24
Clinical significance of telomerase and its associate genes expression in the maintenance of telomere length in squamous cell carcinoma of the esophagus. (16437597)
2005
25
Significance of macrophage chemoattractant protein-1 expression and macrophage infiltration in squamous cell carcinoma of the esophagus. (15330899)
2004
26
SEL1L and squamous cell carcinoma of the esophagus. (15355917)
2004
27
Loss of p16INK4a expression is associated with vascular endothelial growth factor expression in squamous cell carcinoma of the esophagus. (14991568)
2004
28
Cell-cycle regulators and the Ki-67 labeling index can predict the response to chemoradiotherapy and the survival of patients with locally advanced squamous cell carcinoma of the esophagus. (12900371)
2003
29
Diffuse pagetoid squamous cell carcinoma of the esophagus combined with choriocarcinoma and mucoepidermoid carcinoma: an autopsy case report. (11940220)
2002
30
A multi-institutional study of immunohistochemical investigation for the roles of cyclin D1 and E-cadherin in superficial squamous cell carcinoma of the esophagus. (11870667)
2002
31
VEGF-C expression correlates with histological differentiation and metastasis in squamous cell carcinoma of the esophagus. (12168062)
2002
32
Clinicopathological significance of pRb2/p130 expression in squamous cell carcinoma of the esophagus. (12474056)
2002
33
Significance of cyclin B1 expression as an independent prognostic indicator of patients with squamous cell carcinoma of the esophagus. (11895914)
2002
34
p53 protein in esophageal mucosa of individuals at high risk of squamous cell carcinoma of the esophagus. (11869317)
2001
35
Association between p53 immunostaining and cigarette smoking in squamous cell carcinoma of the esophagus. (11185887)
2000
36
Co-occurrence of mucoepidermoid carcinoma and squamous cell carcinoma of the esophagus: report of a case. (10930230)
2000
37
Composite tumor with papillary adenocarcinoma and squamous cell carcinoma of the esophagus: report of a case. (10795870)
2000
38
Expression of ets-1 transcription factor is correlated with penetrating tumor progression in patients with squamous cell carcinoma of the esophagus. (11042559)
2000
39
TP53 mutations and MDM2 gene amplification in squamous-cell carcinomas of the esophagus in south Thailand. (11004672)
2000
40
Genetic polymorphisms of p53 and GSTP1,but not NAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus. (11008209)
2000
41
Vascular endothelial growth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus. (10741747)
2000
42
Immunohistochemical expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in squamous cell carcinoma of the esophagus. (10370644)
1999
43
Relationship between serum levels of soluble interleukin-2 receptor and various disease parameters in patients with squamous cell carcinoma of the esophagus. (10521976)
1999
44
Flow cytometric DNA analysis is useful in detecting multiple genetic alterations in squamous cell carcinoma of the esophagus. (10357400)
1999
45
Immunohistochemical analysis for cell proliferation-related protein expression in small cell carcinoma of the esophagus; a comparative study with small cell carcinoma of the lung and squamous cell carcinoma of the esophagus. (10212809)
1999
46
The prognostic significance of microvessel density and thymidine phosphorylase expression in squamous cell carcinoma of the esophagus. (9529012)
1998
47
p53 gene alternation in squamous cell carcinoma of the esophagus detected by PCR-cold SSCP analysis. (9779600)
1998
48
Altered p16/MTS1/CDKN2 and cyclin D1/PRAD-1 gene expression is associated with the prognosis of squamous cell carcinoma of the esophagus. (9815619)
1997
49
No evidence of mutation in the human PTC gene, responsible for nevoid basal cell carcinoma syndrome, in human primary squamous cell carcinomas of the esophagus and lung. (9140104)
1997
50
CYP1A1, CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus. (9139841)
1997

Genetic Variations for Esophagus Squamous Cell Carcinoma

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Expression for genes affiliated with Esophagus Squamous Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Esophagus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophagus Squamous Cell Carcinoma.

Pathways for genes affiliated with Esophagus Squamous Cell Carcinoma

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29KEGG, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BTRC, CDH1, TGFB1
29.5NOTCH1, CDH1, BTRC
3
Hide members
9.2TGFB1, CDH1, BTRC, VIM
49.2NOTCH1, RAB11A, BTRC

Compounds for genes affiliated with Esophagus Squamous Cell Carcinoma

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1dihydrotestosterone44 28 11 2413.0VIM, TGFB1
2b 723449.9CDH1, VIM
3aristolochic acid44 210.8TGFB1, VIM, CDH1
4cytochalasin d44 5910.7VIM, TGFB1, CDH1
5tgf beta1449.6TGFB1, VIM, CDH1
6hyaluronic acid44 2410.6CDH1, TGFB1, VIM
7formaldehyde44 2410.5VIM, CDH1, TGFB1
85-aza-2deoxycytidine449.5VIM, CDH1, RUNX3
9glycogen44 2410.4VIM, NOTCH1, BTRC, CDH1
10matrigel449.4TGFB1, NOTCH1, CDH1, VIM
11doxorubicin44 49 1111.4VIM, CDH1, NOTCH1, TGFB1
12methotrexate44 49 1111.2TGFB1, CDH1, VIM
13vegf449.1RUNX3, VIM, CDH1, NOTCH1, TGFB1
14retinoic acid44 2410.0TGFB1, VIM, RUNX3, CDH1, NOTCH1
15serine448.8BTRC, RUNX3, TGFB1, CDH1, VIM, NOTCH1

GO Terms for genes affiliated with Esophagus Squamous Cell Carcinoma

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16Gene Ontology
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Biological processes related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-cell adhesionGO:02240810.0CDH1, TGFB1
2negative regulation of myoblast differentiationGO:04566210.0TGFB1, NOTCH1
3negative regulation of ossificationGO:0302799.9TGFB1, NOTCH1
4positive regulation of epithelial to mesenchymal transitionGO:0107189.9TGFB1, NOTCH1
5cellular response to organic cyclic compoundGO:0714079.8BTRC, TGFB1
6endoderm developmentGO:0074929.8TGFB1, NOTCH1
7epithelial to mesenchymal transitionGO:0018379.8TGFB1, NOTCH1
8hair follicle morphogenesisGO:0310699.7RUNX3, NOTCH1
9chondrocyte differentiationGO:0020629.6TGFB1, RUNX3
10positive regulation of transcription, DNA-dependentGO:0458939.3BTRC, CDH1, NOTCH1, TGFB1
11viral life cycleGO:0190589.0TGFB1, RPL7, RPL28

Molecular functions related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.6TGFB1, NOTCH1, RAB11A, CDH1, BTRC, RUNX3

Products for genes affiliated with Esophagus Squamous Cell Carcinoma

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Sources for Esophagus Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet