MCID: ESP027
MIFTS: 34

Esophagus Squamous Cell Carcinoma malady

Summaries for Esophagus Squamous Cell Carcinoma

Sources:
8Disease Ontology, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A sarcoma that begins in flat cells lining the esophagus.

MalaCards: Esophagus Squamous Cell Carcinoma, also known as squamous cell carcinoma of esophagus, is related to squamous cell carcinoma and adenocarcinoma. An important gene associated with Esophagus Squamous Cell Carcinoma is RUNX3 (runt-related transcription factor 3), and among its related pathways are Hippo signaling pathway and Presenilin-Mediated Signaling. The compounds dihydrotestosterone and b 723 have been mentioned in the context of this disorder.

Description from OMIM:47 133239

Aliases & Classifications for Esophagus Squamous Cell Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 47OMIM, 40NCIt, 57SNOMED-CT
See all sources

Aliases & Descriptions:

esophagus squamous cell carcinoma 8 10
squamous cell carcinoma of esophagus 8 61
scc of esophagus 8


External Ids:

Disease Ontology8 DOID:3748
OMIM47 133239
SNOMED-CT57 276804009
NCIt40 C4024

Related Diseases for Esophagus Squamous Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Esophagus Squamous Cell Carcinoma:



Diseases related to esophagus squamous cell carcinoma

Clinical Features for Esophagus Squamous Cell Carcinoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

133239

Drugs & Therapeutics for Esophagus Squamous Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Esophagus Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Esophagus Squamous Cell Carcinoma

Search NIH Clinical Center for Esophagus Squamous Cell Carcinoma

Search CenterWatch for Esophagus Squamous Cell Carcinoma

Genetic Tests for Esophagus Squamous Cell Carcinoma

Anatomical Context for Esophagus Squamous Cell Carcinoma

Animal Models for Esophagus Squamous Cell Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Esophagus Squamous Cell Carcinoma

Sources:
51PubMed
See all sources

Articles related to Esophagus Squamous Cell Carcinoma:

(show top 50)    (show all 168)
idTitleAuthorsYear
1
Reduced expression of DENND2D through promoter hypermethylation is an adverse prognostic factor in squamous cell carcinoma of the esophagus. (24317529)
2014
2
Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan. (24394751)
2014
3
Clinical significance of combined detection of human papilloma virus infection and human telomerase RNA component gene amplification in patients with squamous cell carcinoma of the esophagus in northern China. (23634750)
2013
4
A case of rapidly progressing leiomyosarcoma combined with squamous cell carcinoma in the esophagus. (23983445)
2013
5
Novel drug discovery system for cancer stem cells in human squamous cell carcinoma of the esophagus. (24378718)
2013
6
Notch1 is a 5-fluorouracil resistant and poor survival marker in human esophagus squamous cell carcinomas. (23409141)
2013
7
Basaloid squamous cell carcinoma of the esophagus. (22419439)
2012
8
Prediagnostic smoking and postoperative survival in lymph node-negative esophagus squamous cell carcinoma patients. (22913634)
2012
9
Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia. (23244191)
2012
10
Squamous cell carcinoma in Barrett's esophagus: field effect versus metastasis. (22221671)
2012
11
Analysis of the RUNX3 gene methylation in serum DNA from esophagus squamous cell carcinoma, gastric and colorectal adenocarcinoma patients. (22234069)
2011
12
Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention. (20224884)
2010
13
Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers. (19738459)
2009
14
High orotate phosphoribosyltransferase gene expression predicts complete response to chemoradiotherapy in patients with squamous cell carcinoma of the esophagus. (19307741)
2009
15
Synergistic apoptotic effects of taurolidine and TRAIL on squamous carcinoma cells of the esophagus. (18497982)
2008
16
pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus. (17461478)
2007
17
Significance of immunohistochemical expression of estrogen receptors alpha and beta in squamous cell carcinoma of the esophagus. (17634528)
2007
18
Gene expression profiling of esophageal cancer: comparative analysis of Barrett's esophagus, adenocarcinoma, and squamous cell carcinoma. (17236199)
2007
19
Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagus. (16899597)
2006
20
Value of CK14 and CD56 immunostaining in distinguishing small cell carcinoma from squamous cell carcinoma of the esophagus. (17017394)
2006
21
Bile acid promotes the proliferation of squamous cell carcinoma of the esophagus, independent of its inducing COX-2 expression. (16337966)
2006
22
Cyclooxygenase-2 expression in squamous cell carcinoma of the esophagus. (16984531)
2006
23
Significance of immunohistochemical expression of p27 and involucrin as the marker of cellular differentiation of squamous cell carcinoma of the esophagus. (17878746)
2006
24
Significance of immunohistochemical expression of cyclooxygenase-2 in squamous cell carcinoma of the esophagus. (15701502)
2005
25
Expression of basic fibroblast growth factor is associated with a good outcome in patients with squamous cell carcinoma of the esophagus. (16077964)
2005
26
Complement regulatory proteins in normal human esophagus and esophageal squamous cell carcinoma. (15151618)
2004
27
Expression of cell cycle-regulatory proteins in squamous cell carcinoma of the esophagus]. (12654186)
2003
28
A multi-institutional study of immunohistochemical investigation for the roles of cyclin D1 and E-cadherin in superficial squamous cell carcinoma of the esophagus. (11870667)
2002
29
Expression and prognostic significance of S100A2 protein in squamous cell carcinoma of the esophagus. (11956617)
2002
30
Clinicopathological significance of pRb2/p130 expression in squamous cell carcinoma of the esophagus. (12474056)
2002
31
Basaloid squamous cell carcinoma of the esophagus: an immunohistochemical study of 8 cases. (11677772)
2001
32
Early basaloid squamous cell carcinoma of the esophagus. (11174312)
2001
33
Association between p53 immunostaining and cigarette smoking in squamous cell carcinoma of the esophagus. (11185887)
2000
34
Genetic steps in the development of squamous cell carcinoma of the esophagus. (10767643)
2000
35
TP53 mutations and MDM2 gene amplification in squamous-cell carcinomas of the esophagus in south Thailand. (11004672)
2000
36
Genetic polymorphisms of p53 and GSTP1,but not NAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus. (11008209)
2000
37
Expression of Bcl-2 and amplification of c-myc are frequent in basaloid squamous cell carcinomas of the esophagus. (10514383)
1999
38
Relationship between serum levels of soluble interleukin-2 receptor and various disease parameters in patients with squamous cell carcinoma of the esophagus. (10521976)
1999
39
Histochemical study of vascular endothelial growth factor in squamous cell carcinoma of the esophagus. (10370645)
1999
40
Expression of cyclooxygenase-2 in human squamous cell carcinoma of the esophagus; an immunohistochemical survey. (10226539)
1999
41
The prognostic significance of microvessel density and thymidine phosphorylase expression in squamous cell carcinoma of the esophagus. (9529012)
1998
42
p53 gene alternation in squamous cell carcinoma of the esophagus detected by PCR-cold SSCP analysis. (9779600)
1998
43
No evidence of mutation in the human PTC gene, responsible for nevoid basal cell carcinoma syndrome, in human primary squamous cell carcinomas of the esophagus and lung. (9140104)
1997
44
Immunohistochemical expression of bcl-2 protein in squamous cell carcinoma and basaloid carcinoma of the esophagus. (9306579)
1997
45
Basaloid squamous cell carcinoma of the esophagus: diagnosis and prognosis. (9149011)
1997
46
Immunohistochemical studies of vascular volume and proliferative activity in squamous cell carcinoma of the esophagus. (9017984)
1997
47
CD44 expression in dysplastic epithelium and squamous-cell carcinoma of the esophagus. (8797863)
1996
48
bcl-2 expression and prognosis in squamous-cell carcinomas of the esophagus. (8797876)
1996
49
Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q. (8603412)
1996
50
Activity of taxol in patients with squamous cell carcinoma and adenocarcinoma of the esophagus. (7912736)
1994

Genetic Variations for Esophagus Squamous Cell Carcinoma

Expression for genes affiliated with Esophagus Squamous Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Esophagus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Esophagus Squamous Cell Carcinoma.

Pathways for genes affiliated with Esophagus Squamous Cell Carcinoma

Sources:
30KEGG, 52QIAGEN, 38NCBI BioSystems Database
See all sources

Pathways related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BTRC, CDH1, TGFB1
29.5NOTCH1, CDH1, BTRC
3
Hide members
9.2TGFB1, CDH1, BTRC, VIM
49.2NOTCH1, RAB11A, BTRC

Compounds for genes affiliated with Esophagus Squamous Cell Carcinoma

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1dihydrotestosterone45 29 11 2413.0VIM, TGFB1
2b 723459.9CDH1, VIM
3aristolochic acid45 210.8TGFB1, CDH1, VIM
4cytochalasin d45 6010.7VIM, CDH1, TGFB1
5tgf beta1459.6TGFB1, CDH1, VIM
6hyaluronic acid45 2410.6VIM, CDH1, TGFB1
7formaldehyde45 2410.5TGFB1, CDH1, VIM
85-aza-2deoxycytidine459.5VIM, RUNX3, CDH1
9glycogen45 2410.4NOTCH1, CDH1, BTRC, VIM
10matrigel459.4TGFB1, NOTCH1, CDH1, VIM
11doxorubicin45 50 1111.4VIM, CDH1, NOTCH1, TGFB1
12methotrexate45 50 1111.2TGFB1, CDH1, VIM
13vegf459.1VIM, RUNX3, CDH1, NOTCH1, TGFB1
14retinoic acid45 2410.0TGFB1, NOTCH1, CDH1, RUNX3, VIM
15serine458.8VIM, RUNX3, BTRC, CDH1, NOTCH1, TGFB1

GO Terms for genes affiliated with Esophagus Squamous Cell Carcinoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-cell adhesionGO:02240810.0CDH1, TGFB1
2negative regulation of myoblast differentiationGO:04566210.0TGFB1, NOTCH1
3negative regulation of ossificationGO:0302799.9TGFB1, NOTCH1
4positive regulation of epithelial to mesenchymal transitionGO:0107189.9TGFB1, NOTCH1
5cellular response to organic cyclic compoundGO:0714079.8BTRC, TGFB1
6endoderm developmentGO:0074929.8TGFB1, NOTCH1
7epithelial to mesenchymal transitionGO:0018379.8TGFB1, NOTCH1
8hair follicle morphogenesisGO:0310699.7RUNX3, NOTCH1
9chondrocyte differentiationGO:0020629.6TGFB1, RUNX3
10positive regulation of transcription, DNA-dependentGO:0458939.3BTRC, CDH1, NOTCH1, TGFB1
11viral life cycleGO:0190589.0TGFB1, RPL7, RPL28

Molecular functions related to Esophagus Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.6TGFB1, NOTCH1, RAB11A, CDH1, BTRC, RUNX3

Products for genes affiliated with Esophagus Squamous Cell Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Esophagus Squamous Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet