MCID: EST005
MIFTS: 43

Esotropia

Categories: Rare diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Esotropia

MalaCards integrated aliases for Esotropia:

Name: Esotropia 12 72 49 28 14 69
Convergence in Manifest Squint 12
Internal Strabismus 12
Crossed Eyes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9840
ICD10 32 H50.0 H50.00
ICD9CM 34 378.0 378.00
MeSH 41 D004948
NCIt 46 C34596
UMLS 69 C0014877

Summaries for Esotropia

Disease Ontology : 12 Esotropia is a strabismus in which the eye turns inward toward the nose.

MalaCards based summary : Esotropia, also known as convergence in manifest squint, is related to accommodative esotropia and exotropia. An important gene associated with Esotropia is ANKRD11 (Ankyrin Repeat Domain 11). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are hearing/vestibular/ear and mortality/aging

Wikipedia : 72 Esotropia is a form of strabismus in which one or both eyes turns inward. The condition can be... more...

Related Diseases for Esotropia

Diseases related to Esotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 accommodative esotropia 33.4 CHN1 COG8
2 exotropia 31.8 CHN1 ROBO3 TUBB3
3 congenital ptosis 29.8 CHN1 TUBB3
4 strabismus 29.7 ADAT3 CHN1 COL11A1 SOBP TUBB3
5 anisometropia 29.6 CHN1 COG8 OPTN
6 amblyopia 29.5 CHN1 OPTN SOBP TUBB3
7 duane retraction syndrome 29.3 CHN1 TUBB3
8 hypotropia 29.2 CHN1 OPTN TUBB3
9 alternating esotropia 12.1
10 monocular esotropia 12.1
11 blepharophimosis with ptosis, syndactyly, and short stature 11.6
12 abducens nerve disease 11.2
13 moebius syndrome 10.9
14 hemifacial hyperplasia with strabismus 10.9
15 marshall syndrome 10.9
16 temtamy syndrome 10.9
17 richieri-costa/guion-almeida syndrome 10.9
18 spinocerebellar ataxia, x-linked 3 10.9
19 mental retardation, anterior maxillary protrusion, and strabismus 10.9
20 mental retardation, autosomal recessive 36 10.9
21 incontinentia pigmenti 10.8
22 oculocutaneous albinism 10.8
23 myopia 10.2
24 aging 10.2
25 marcus gunn phenomenon 10.1 CHN1 TUBB3
26 hypertropia 10.1 CHN1 TUBB3
27 vitreous syneresis 10.1 COL11A1 OPTN
28 deafness, autosomal dominant 28 10.1 CHN1 TUBB3
29 poland syndrome 10.1 CHN1 TUBB3
30 paralytic squint 10.1 CHN1 TUBB3
31 refractive error 10.0
32 monofixation syndrome 10.0
33 primary angle-closure glaucoma 10.0 COL11A1 OPTN
34 cranial nerve disease 10.0 CHN1 TUBB3
35 cataract 10.0
36 ptosis 10.0
37 cerebritis 10.0
38 supranuclear ocular palsy 10.0
39 duane retraction syndrome 1 9.9
40 cerebral palsy 9.9
41 retinitis 9.9
42 tukel syndrome 9.9 CHN1 ROBO3 TUBB3
43 ocular motility disease 9.9 CHN1 ROBO3 TUBB3
44 peripheral nervous system disease 9.9 CHN1 TUBB3
45 down syndrome 9.9
46 glass syndrome 9.9
47 scoliosis 9.9
48 astrocytoma 9.9
49 abducens palsy 9.8
50 sturge-weber syndrome 9.8

Graphical network of the top 20 diseases related to Esotropia:



Diseases related to Esotropia

Symptoms & Phenotypes for Esotropia

MGI Mouse Phenotypes related to Esotropia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.26 ANKRD11 COL11A1 ROBO3 SOBP
2 mortality/aging MP:0010768 9.23 ANKRD11 CHN1 COL11A1 OPTN ROBO3 SURF1

Drugs & Therapeutics for Esotropia

Drugs for Esotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 abobotulinumtoxinA Phase 4
3 Cholinergic Agents Phase 4
4 Neuromuscular Agents Phase 4
5 Neurotransmitter Agents Phase 4
6 onabotulinumtoxinA Phase 4
7 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
8 Pharmaceutical Solutions Phase 4
9 Botulinum Toxins Phase 4
10 Botulinum Toxins, Type A Phase 4
11
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
12
Bupivacaine Approved, Investigational Phase 2, Phase 3 38396-39-3, 2180-92-9 2474
13 Racepinephrine Approved Phase 2, Phase 3 329-65-7
14 Central Nervous System Depressants Phase 2, Phase 3
15 Anesthetics Phase 2, Phase 3
16 Anesthetics, Local Phase 2, Phase 3
17 Epinephryl borate Phase 2, Phase 3
18
Lidocaine Approved, Vet_approved 137-58-6 3676
19
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
20 tannic acid Approved, Nutraceutical

Interventional clinical trials:

(show all 24)

# Name Status NCT ID Phase Drugs
1 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
2 A Trial of Bifocals in Myopic Children With Esophoria Unknown status NCT00000128 Phase 3
3 An Observational Study of Infantile, Acquired Non-accommodative, and Acquired Partially-accommodative Esotropia Completed NCT00310960 Phase 3
4 Bilateral Recession or Unilateral Recession-Resection as Surgery for Infantile Esotropia Completed NCT00304577 Phase 3
5 The Prism Adaptation Study (PAS) Completed NCT00000121 Phase 3
6 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
7 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
8 Eye Muscle Surgery to Treat Congenital Nystagmus Completed NCT00001866 Phase 2
9 Conservative Treatment of Esotropia in Children up to 3 Years Old Unknown status NCT02404324
10 Surgery for Esotropia Under Topical Anesthesia Unknown status NCT00993174
11 Long-Term Outcomes in the Treatment of Infantile and Acquired Esotropia With Botulinum Toxin Completed NCT00746304
12 Under-correction in Refractive Accommodative Esotropia Completed NCT01179711
13 Congenital Esotropia Observational Study (CEOS) Completed NCT00000163
14 Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye Completed NCT00001143
15 Binocular Treatment of Amblyopia Before and After Strabismus Surgery Completed NCT01791946
16 Outcome Following Phacoemulsification Versus Small Incision Cataract Surgery (SICS) Completed NCT00821223
17 Bifocal Soft Contact Lenses and Their Effect on Myopia Progression in Children and Adolescents. Completed NCT00214487
18 Early Versus Delayed Surgery for Infantile Esotropia Recruiting NCT01166503
19 Comparison Between Augmented Recession and Posterior Scleral Fixation in Partially Accommodative Esotropia Recruiting NCT02413463
20 Strabismus Surgery and Driving Ability Recruiting NCT02570555
21 IRIS Registry: Intelligent Research in Sight Registry Recruiting NCT02485847
22 Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia Active, not recruiting NCT01032603
23 Botulinum Toxin Augmented Surgery vs Conventional Surgery in the Management of Large Angle Infantile Esotropia Not yet recruiting NCT03266549
24 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836

Search NIH Clinical Center for Esotropia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Esotropia

Genetic tests related to Esotropia:

# Genetic test Affiliating Genes
1 Esotropia 28

Anatomical Context for Esotropia

MalaCards organs/tissues related to Esotropia:

38
Eye, Brain, Testes, Pituitary, Retina, Thyroid

Publications for Esotropia

Articles related to Esotropia:

(show top 50) (show all 744)
# Title Authors Year
1
Accommodative esotropia: the state of the art. ( 29332227 )
2018
2
Reduction of Consecutive Esotropia Using Modified Contralateral Recession and Resection for Recurrent Intermittent Exotropia. ( 28991342 )
2018
3
Accommodative Esotropia Treatment Plan Utilizing Simultaneous Strabismus Surgery and Photorefractive Keratectomy. ( 29339065 )
2018
4
Esotropia and Exotropia Preferred Practice PatternAr. ( 29108746 )
2018
5
Evaluation and surgical outcome of acquired nonaccommodative esotropia among older children. ( 29426440 )
2018
6
Anterior Segment Changes during Accommodation in Accommodative Esotropia. ( 29376230 )
2018
7
Evaluation and Management of Acute Acquired Comitant Esotropia in Children. ( 27726470 )
2017
8
Clinical profiles and surgical outcomes of adult esotropia. ( 28774524 )
2017
9
Outcome of early surgery in infantile esotropia: Our experience in tertiary care hospital. ( 28924312 )
2017
10
Postoperative esotropia: initial overcorrection or consecutive esotropia? ( 28430327 )
2017
11
Orbital magnetic resonance imaging is useful in age-related distance esotropia. ( 28601401 )
2017
12
Stereopsis in patients with refractive accommodative esotropia. ( 28532705 )
2017
13
Combined resection-recession versus combined recession-retroequatorial myopexy of medial rectus muscles for treatment of near-distance disparity Esotropia. ( 28652690 )
2017
14
Acquired Adult Onset Cyclic Esotropia in Patients With Myopic Strabismus Fixus and Intraocular Lens Implantation. ( 28692503 )
2017
15
Esotropia following botulinum toxin type A injection for facial wrinkles. ( 28682151 )
2017
16
To what extent may Botulinum toxin type A injections be an alternative choice to surgery in infantile esotropia? ( 28362053 )
2017
17
Time and Factors Affecting the Direction of Re-drift in Essential Infantile Esotropia. ( 29131911 )
2017
18
Resection and anterior transposition of the inferior oblique muscle for treatment of inferior rectus muscle hypoplasia with esotropia. ( 29260082 )
2017
19
Acute concomitant esotropia in children. ( 28574208 )
2017
20
Superior and Lateral Rectus Myopexy for Acquired Adult Distance Esotropia: A "One Size Fits All" Surgery. ( 28759293 )
2017
21
Stability and effects of muscle transplantation for very large angle esotropia: A study of 22 patients. ( 28724819 )
2017
22
Novel Eye Movement Disorders in Whipple's Disease-Staircase Horizontal Saccades, Gaze-Evoked Nystagmus, and Esotropia. ( 28744253 )
2017
23
A retrospective evaluation of bilateral medial rectus recession for management of accommodative esotropia according to prism-adapted motor response preoperatively. ( 28232011 )
2017
24
Clinical features of acute acquired comitant esotropia in the Chinese populations. ( 29145257 )
2017
25
Transient Esotropia in the Child: Case Report and Review of the Literature. ( 28559837 )
2017
26
Unilateral lateral rectus muscle advancement surgery based on one-fourth of the angle of consecutive esotropia. ( 29284428 )
2017
27
The Use of Botulinum Toxin to Treat Infantile Esotropia: A Systematic Review With Meta-Analysis. ( 29059315 )
2017
28
Bimedial rectus muscle elongation versus bimedial rectus muscle recession for the surgical treatment of large-angle infantile esotropia. ( 29081649 )
2017
29
Esotropia with an accommodative component after surgery for infantile esotropia compared to primary accommodative esotropia. ( 28104501 )
2017
30
Unilateral Recession-Resection Surgery for Infantile Esotropia: Survival of Motor Outcomes and Postoperative Drifts. ( 28488915 )
2017
31
Cortical Visual Connections via the Corpus Callosum are Asymmetrical in Human Infantile Esotropia. ( 29279026 )
2017
32
Surgical Treatment of Adult-Onset Esotropia: Characteristics and Outcomes. ( 28092393 )
2017
33
Comparison of botulinum toxin with surgery for the treatment of acute-onset, comitant esotropia in children. ( 28057455 )
2017
34
Increase in esodeviation under cycloplegia with 0.5% tropicamide and 0.5% phenylephrine mixed eye drops in patients with hyperopia and esotropia. ( 29233124 )
2017
35
Medial Rectus Bridge Faden Operations in Accommodative and Partially Accommodative Esotropia With Convergence Excess. ( 28991347 )
2017
36
Y-Split Recession of the Medial Rectus Muscle as a Secondary and/or Unilateral Procedure in the Treatment of Esotropia with Distance/Near Disparity. ( 28804647 )
2017
37
Medial and Lateral Rectus Muscle Insertion Distance and Width in Esotropia and Exotropia Patients. ( 28632404 )
2017
38
Wright central plication of lateral rectus versus standard medial rectus recession in adult divergence insufficiency esotropia. ( 28315403 )
2017
39
Re: Whitman etA al.: Bifocals fail to improve stereopsis outcomes in high AC/A accommodative esotropia (Ophthalmology 2016;123:690-696). ( 27993269 )
2017
40
Management of idiopathic intracranial hypertension in an infant with bilateral congenital cataract and associated comitant sensory esotropia. ( 29044088 )
2017
41
Outcomes after the surgery for acquired nonaccommodative esotropia. ( 28738831 )
2017
42
Atypical presentation of acute acquired comitant esotropia. ( 27597443 )
2016
43
Comparison of Surgical Success for Infantile Esotropia and Strabismus Associated with Neurological Impairment. ( 27532638 )
2016
44
Age-related distance esotropia: Clinical features and therapeutic outcomes. ( 27255989 )
2016
45
Childhood esotropia: child and parent concerns. ( 27381528 )
2016
46
Esotropia Surgery Considering the Angle under General Anesthesia. ( 27532158 )
2016
47
Surgical Responses of Medial Rectus Muscle Recession in Thyroid Eye Disease-Related Esotropia. ( 26796354 )
2016
48
Management of a Case of Undercorrection Following Surgery for Infantile Esotropia. ( 27858944 )
2016
49
Accommodative spasm might influence surgical planning and outcomes in acute acquired distance esotropia in myopia. ( 27515204 )
2016
50
Infantile esotropia: risk factors associated with reoperation. ( 27799735 )
2016

Variations for Esotropia

ClinVar genetic disease variations for Esotropia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ANKRD11 NM_013275.5(ANKRD11): c.5317G> T (p.Glu1773Ter) single nucleotide variant Pathogenic rs1114167291 GRCh37 Chromosome 16, 89347633: 89347633

Expression for Esotropia

Search GEO for disease gene expression data for Esotropia.

Pathways for Esotropia

GO Terms for Esotropia

Biological processes related to Esotropia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inner ear morphogenesis GO:0042472 8.96 COL11A1 SOBP
2 skeletal system morphogenesis GO:0048705 8.62 ANKRD11 COL11A1

Sources for Esotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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