MCID: EST005
MIFTS: 41

Esotropia malady

Categories: Rare diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Esotropia

Aliases & Descriptions for Esotropia:

Name: Esotropia 12 50 29 14 69
Convergence in Manifest Squint 12
Internal Strabismus 12
Crossed Eyes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9840
ICD10 33 H50.0 H50.00
ICD9CM 35 378.0 378.00
MeSH 42 D004948
NCIt 47 C34596
UMLS 69 C0014877

Summaries for Esotropia

Disease Ontology : 12 Esotropia is a strabismus in which the eye turns inward toward the nose.

MalaCards based summary : Esotropia, also known as convergence in manifest squint, is related to accommodative esotropia and alternating esotropia. An important gene associated with Esotropia is ROBO3 (Roundabout Guidance Receptor 3). The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotype is mortality/aging.

Wikipedia : 71 Esotropia is a form of strabismus in which one or both eyes turns inward. The condition can be... more...

Related Diseases for Esotropia

Diseases related to Esotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
id Related Disease Score Top Affiliating Genes
1 accommodative esotropia 12.1
2 alternating esotropia 12.0
3 monocular esotropia 12.0
4 exotropia 11.2
5 blepharophimosis with ptosis, syndactyly, and short stature 10.9
6 moebius syndrome 10.9
7 richieri-costa/guion-almeida syndrome 10.8
8 marshall syndrome 10.8
9 mental retardation, anterior maxillary protrusion, and strabismus 10.8
10 mental retardation, autosomal recessive 36 10.8
11 craniofrontonasal dysplasia 10.7
12 infantile neuroaxonal dystrophy 1 10.7
13 incontinentia pigmenti 10.7
14 febrile seizures, familial, 1 10.2 CHN1 ROBO3
15 endometriosis of ovary 10.2 CHN1 ROBO3
16 strabismus 10.2
17 joubert syndrome 6 10.1 CHN1 OPTN
18 ureter cancer 10.1 COL11A1 OPTN
19 ulceration of vulva 10.1 CHN1 ROBO3
20 chronic lacrimal gland enlargement 10.1 CHN1 ROBO3
21 lingual-facial-buccal dyskinesia 10.1 CHN1 SAMHD1
22 myopia 10.1
23 alopecia areata 10.1 CHN1 SAMHD1
24 amyotrophic neuralgia 10.1 CHN1 OPTN
25 mental retardation, autosomal dominant 7 10.1 CHN1 ROBO3
26 total third-nerve palsy 10.1 CHN1 SAMHD1
27 cogan syndrome 10.0 OPTN SAMHD1
28 amyotrophic lateral sclerosis 10, with or without ftd 10.0 OPTN SAMHD1
29 amblyopia 10.0
30 femoral vein thrombophlebitis 10.0 CHN1 COG8 OPTN
31 interstitial keratitis 10.0 CHN1 COG8 SAMHD1
32 pelvic varices 10.0 OPTN SAMHD1
33 refractive error 9.9
34 anisometropia 9.9
35 monofixation syndrome 9.9
36 acute poststreptococcal glomerulonephritis 9.9 COL11A1 OPTN
37 cerebritis 9.9
38 ptosis 9.9
39 cataract 9.8
40 cerebral palsy 9.8
41 retinitis 9.8
42 down syndrome 9.8
43 astrocytoma 9.8
44 scoliosis 9.8
45 lymphoblastic leukemia 9.7
46 weber syndrome 9.7
47 abnormal retinal correspondence 9.7
48 eye disease 9.7
49 abducens palsy 9.7
50 hemangioma 9.7

Graphical network of the top 20 diseases related to Esotropia:



Diseases related to Esotropia

Symptoms & Phenotypes for Esotropia

MGI Mouse Phenotypes related to Esotropia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.23 CHN1 COL11A1 EBP OPTN ROBO3 SAMHD1

Drugs & Therapeutics for Esotropia

Drugs for Esotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 Cholinergic Agents Phase 4
3 Neuromuscular Agents Phase 4
4 Neurotransmitter Agents Phase 4
5 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
6 Pharmaceutical Solutions Phase 4
7 abobotulinumtoxinA Phase 4
8 incobotulinumtoxinA Phase 4
9 onabotulinumtoxinA Phase 4
10 Botulinum Toxins Phase 4
11 Botulinum Toxins, Type A Phase 4
12
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
13
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
14 Anesthetics Phase 2, Phase 3
15 Central Nervous System Depressants Phase 2, Phase 3
16 Anesthetics, Local Phase 2, Phase 3
17 Epinephryl borate Phase 2, Phase 3
18 Racepinephrine Phase 2, Phase 3
19
Lidocaine Approved, Vet_approved 137-58-6 3676
20
Benzocaine Approved 1994-09-7, 94-09-7 2337
21 tannic acid Approved, Nutraceutical

Interventional clinical trials:

(show all 23)
id Name Status NCT ID Phase
1 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4
2 A Trial of Bifocals in Myopic Children With Esophoria Unknown status NCT00000128 Phase 3
3 An Observational Study of Infantile, Acquired Non-accommodative, and Acquired Partially-accommodative Esotropia Completed NCT00310960 Phase 3
4 Bilateral Recession or Unilateral Recession-Resection as Surgery for Infantile Esotropia Completed NCT00304577 Phase 3
5 The Prism Adaptation Study (PAS) Completed NCT00000121 Phase 3
6 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
7 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3
8 Eye Muscle Surgery to Treat Congenital Nystagmus Completed NCT00001866 Phase 2
9 Surgery for Esotropia Under Topical Anesthesia Unknown status NCT00993174
10 Long-Term Outcomes in the Treatment of Infantile and Acquired Esotropia With Botulinum Toxin Completed NCT00746304
11 Under-correction in Refractive Accommodative Esotropia Completed NCT01179711
12 Congenital Esotropia Observational Study (CEOS) Completed NCT00000163
13 Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye Completed NCT00001143
14 Binocular Treatment of Amblyopia Before and After Strabismus Surgery Completed NCT01791946
15 Outcome Following Phacoemulsification Versus Small Incision Cataract Surgery (SICS) Completed NCT00821223
16 Bifocal Soft Contact Lenses and Their Effect on Myopia Progression in Children and Adolescents. Completed NCT00214487
17 Early Versus Delayed Surgery for Infantile Esotropia Recruiting NCT01166503
18 Comparison Between Augmented Recession and Posterior Scleral Fixation in Partially Accommodative Esotropia Recruiting NCT02413463
19 Strabismus Surgery and Driving Ability Recruiting NCT02570555
20 IRIS Registry: Intelligent Research in Sight Registry Recruiting NCT02485847
21 Conservative Treatment of Esotropia in Children up to 3 Years Old Active, not recruiting NCT02404324
22 Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia Active, not recruiting NCT01032603
23 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836

Search NIH Clinical Center for Esotropia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Esotropia

Genetic tests related to Esotropia:

id Genetic test Affiliating Genes
1 Esotropia 29

Anatomical Context for Esotropia

MalaCards organs/tissues related to Esotropia:

39
Eye, Brain, Testes, Pituitary, Retina, Thyroid

Publications for Esotropia

Articles related to Esotropia:

(show top 50) (show all 706)
id Title Authors Year
1
Evaluation and Management of Acute Acquired Comitant Esotropia in Children. ( 27726470 )
2017
2
Surgical Treatment of Adult-Onset Esotropia: Characteristics and Outcomes. ( 28092393 )
2017
3
Comparison of botulinum toxin with surgery for the treatment of acute-onset, comitant esotropia in children. ( 28057455 )
2017
4
Re: Whitman etA al.: Bifocals fail to improve stereopsis outcomes in high AC/A accommodative esotropia (Ophthalmology 2016;123:690-696). ( 27993269 )
2017
5
Cyclic esotropia and impaired vision after strabismus surgery. ( 27765448 )
2016
6
The long-term outcomes in children who are not compliant with spectacle treatment for accommodative esotropia. ( 27192603 )
2016
7
Case 3: A 28-month-old with esotropia and acute lymphoblastic leukemia. ( 27398052 )
2016
8
Childhood esotropia: child and parent concerns. ( 27381528 )
2016
9
Stepwise increase of hypermetropic correction using contact lenses in intermittent partially accommodative esotropia. ( 26888473 )
2016
10
Long-term motor and sensory outcomes after surgery for infantile esotropia. ( 27430111 )
2016
11
Sensorial status in patients with pure accomodative esotropia. ( 27443600 )
2016
12
Congenitally Impaired Disparity Vergence in Children With Infantile Esotropia. ( 27159445 )
2016
13
High AC/A Ratio Esotropia: Do We Really Need to Be Using Bifocals? ( 27799577 )
2016
14
Accommodative spasm might influence surgical planning and outcomes in acute acquired distance esotropia in myopia. ( 27515204 )
2016
15
Comparison of Surgical Success for Infantile Esotropia and Strabismus Associated with Neurological Impairment. ( 27532638 )
2016
16
Early alignment versus delayed alignment in patients with hyperopia and esotropia. ( 26917063 )
2016
17
Comparison of the Wave Amplitude of Visually Evoked Potential in Amblyopic Eyes between Patients with Esotropia and Anisometropia and a Normal Group. ( 26989279 )
2016
18
Cyclic esotropia with development of a high accommodative convergenceA toA accommodation ratio after surgery for intermittent exotropia. ( 27628586 )
2016
19
On surgical planning and innervation in pontine gaze palsy with ipsilateral esotropia. ( 27651233 )
2016
20
Acute acquired comitant esotropia related to excessive Smartphone use. ( 27061181 )
2016
21
Are Bifocals Necessary for Children with High AC/A Esotropia? ( 27012696 )
2016
22
Infantile esotropia: risk factors associated with reoperation. ( 27799735 )
2016
23
Acute acquired concomitant esotropia and decompensated monofixation syndrome: a sensory-motor status assessment. ( 27521664 )
2016
24
Esotropia Surgery Considering the Angle under General Anesthesia. ( 27532158 )
2016
25
Spontaneous Regression of Over-elevation in Adduction Following Esotropia Surgery. ( 26836001 )
2016
26
Bifocals Fail to Improve Stereopsis Outcomes in High AC/A Accommodative Esotropia. ( 26854034 )
2016
27
Surgical Responses of Medial Rectus Muscle Recession in Thyroid Eye Disease-Related Esotropia. ( 26796354 )
2016
28
Atypical presentation of acute acquired comitant esotropia. ( 27597443 )
2016
29
Variability in Response to Bilateral Medial Rectus Recessions in Infantile Esotropia. ( 27486726 )
2016
30
Adult-onset chronic divergence insufficiency esotropia: clinical features and response to surgery. ( 26988776 )
2016
31
The long-term outcomes in children who are not compliant with spectacle treatment for accommodative esotropia. ( 27312968 )
2016
32
Longitudinal Development of Refractive Error in Children With Accommodative Esotropia: Onset, Amblyopia, and Anisometropia. ( 27116548 )
2016
33
Double Augmented Vertical Rectus Transposition for Large-Angle Esotropia Due to Sixth Nerve Palsy. ( 27537250 )
2016
34
Accommodative ET-High AC/A Ratio Esotropia: The Case for Glasses. ( 27799576 )
2016
35
Essential Infantile Esotropia: Postoperative Sensory Outcomes of Strabismus Surgery. ( 27367798 )
2016
36
Horizontal gaze palsy and progressive scoliosis in a patient with congenital esotropia and inability to abduct. A case report. ( 27318526 )
2016
37
Comparison between medial rectus pulley fixation and augmented recession in children with convergence excess and variable angle infantile esotropia. ( 27647120 )
2016
38
Long-Term Changes in Refractive Error and Clinical Evaluation in Partially Accommodative Esotropia after Surgery. ( 27936115 )
2016
39
Tonic pupil after botulinum toxin-A injection for treatment ofA esotropia in children. ( 26917081 )
2016
40
Re: Brodsky etA al.: Intermittent exotropia andA accommodative esotropia: distinct disorders or two ends of a spectrum? (Ophthalmology 2015;122:1543-6). ( 26902571 )
2016
41
Age-related distance esotropia: Clinical features and therapeutic outcomes. ( 27255989 )
2016
42
Botulinum toxin type A as treatment of partially accommodative esotropia. ( 26747023 )
2016
43
Management of a Case of Undercorrection Following Surgery for Infantile Esotropia. ( 27858944 )
2016
44
Acute Acquired Comitant Esotropia in Adults: Is It Neurologic or Not? ( 28018672 )
2016
45
"Effectiveness of Bilateral Lateral Rectus Resection for Residual Esotropia in Dysthyroid Ophthalmopathy". ( 27590120 )
2016
46
Essential infantile esotropia with inferior oblique hyperfunction: long term follow-up of 6 muscles approach. ( 28003983 )
2016
47
Ptosis, Miosis, and Intermittent Esotropia Following Pituitary Adenoma Resection. ( 27355788 )
2016
48
Plication augmentation of the modified Hummelsheim procedure for treatment of large-angle esotropia due to abducens nerve palsy and type 1 Duane syndrome. ( 26235793 )
2015
49
Pediatric Experience in Surgical Treatment of Acquired Esotropia Associated With High Myopia. ( 26053212 )
2015
50
Reply to 'Results of conservative management for consecutive esotropia after intermittent exotropia surgery'. ( 26315698 )
2015

Variations for Esotropia

Expression for Esotropia

Search GEO for disease gene expression data for Esotropia.

Pathways for Esotropia

GO Terms for Esotropia

Molecular functions related to Esotropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding, bridging GO:0030674 8.62 COL11A1 OPTN

Sources for Esotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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