MCID: EST005
MIFTS: 42

Esotropia

Categories: Rare diseases, Neuronal diseases, Eye diseases

Aliases & Classifications for Esotropia

MalaCards integrated aliases for Esotropia:

Name: Esotropia 12 50 29 14 69
Convergence in Manifest Squint 12
Internal Strabismus 12
Crossed Eyes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9840
ICD10 33 H50.0 H50.00
ICD9CM 35 378.0 378.00
MeSH 42 D004948
NCIt 47 C34596
UMLS 69 C0014877

Summaries for Esotropia

Disease Ontology : 12 Esotropia is a strabismus in which the eye turns inward toward the nose.

MalaCards based summary : Esotropia, also known as convergence in manifest squint, is related to monofixation syndrome and accommodative esotropia. An important gene associated with Esotropia is ANKRD11 (Ankyrin Repeat Domain 11). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related phenotypes are hearing/vestibular/ear and mortality/aging

Wikipedia : 72 Esotropia is a form of strabismus in which one or both eyes turns inward. The condition can be... more...

Related Diseases for Esotropia

Diseases related to Esotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
id Related Disease Score Top Affiliating Genes
1 monofixation syndrome 24.1 ADAT3 ANKRD11 CHN1 COG8 COL11A1 OPTN
2 accommodative esotropia 12.0
3 alternating esotropia 12.0
4 monocular esotropia 12.0
5 blepharophimosis with ptosis, syndactyly, and short stature 11.5
6 exotropia 11.2
7 moebius syndrome 10.8
8 marshall syndrome 10.7
9 mental retardation, anterior maxillary protrusion, and strabismus 10.7
10 temtamy syndrome 10.7
11 mental retardation, autosomal recessive 36 10.7
12 hemifacial hyperplasia with strabismus 10.7
13 richieri-costa/guion-almeida syndrome 10.7
14 spinocerebellar ataxia, x-linked 3 10.7
15 infantile neuroaxonal dystrophy 1 10.7
16 infantile cerebellar-retinal degeneration 10.7
17 incontinentia pigmenti 10.7
18 craniofrontonasal dysplasia 10.7
19 coats disease 10.7
20 ureter cancer 10.3 COL11A1 OPTN
21 coloboma of macula and skeletal anomalies 10.3 CHN1 TUBB3
22 endometriosis of ovary 10.2 CHN1 TUBB3
23 mental retardation, autosomal recessive 59 10.2 CHN1 TUBB3
24 total circumpapillary dystrophy of choroid 10.2 CHN1 COG8
25 acute poststreptococcal glomerulonephritis 10.2 COL11A1 OPTN
26 polydactyly, postaxial, with progressive myopia 10.2 CHN1 TUBB3
27 abducens nerve disease 10.2 CHN1 TUBB3
28 strabismus 10.2
29 myopia 10.1
30 ulceration of vulva 10.1 CHN1 TUBB3
31 pleomorphic carcinoma 10.1 CHN1 TUBB3
32 amblyopia 10.0
33 microcephaly-micromelia syndrome 9.9 CHN1 ROBO3 TUBB3
34 anisometropia 9.9
35 refractive error 9.9
36 enterocele 9.9 CHN1 ROBO3 TUBB3
37 pancreatic acinar cell adenocarcinoma 9.9 CHN1 TUBB3
38 ptosis 9.9
39 cerebritis 9.9
40 iris hypoplasia 9.9 ADAT3 ANKRD11 SOBP
41 cataract 9.8
42 cerebral palsy 9.8
43 retinitis 9.8
44 peripheral vertigo 9.8 CHN1 OPTN TUBB3
45 down syndrome 9.8
46 scoliosis 9.8
47 astrocytoma 9.8
48 femoral vein thrombophlebitis 9.7 CHN1 COG8 OPTN
49 rippling muscle disease 9.7
50 hemangioma 9.7

Graphical network of the top 20 diseases related to Esotropia:



Diseases related to Esotropia

Symptoms & Phenotypes for Esotropia

MGI Mouse Phenotypes related to Esotropia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.26 ANKRD11 COL11A1 ROBO3 SOBP
2 mortality/aging MP:0010768 9.23 ANKRD11 CHN1 COL11A1 OPTN ROBO3 SURF1

Drugs & Therapeutics for Esotropia

Drugs for Esotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 abobotulinumtoxinA Phase 4
3 Botulinum Toxins Phase 4
4 Botulinum Toxins, Type A Phase 4
5 Cholinergic Agents Phase 4
6 Neuromuscular Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 onabotulinumtoxinA Phase 4
9 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
10 Pharmaceutical Solutions Phase 4
11
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
12
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
13 Racepinephrine Approved Phase 2, Phase 3
14 Anesthetics Phase 2, Phase 3
15 Central Nervous System Depressants Phase 2, Phase 3
16 Anesthetics, Local Phase 2, Phase 3
17 Epinephryl borate Phase 2, Phase 3
18
Lidocaine Approved, Vet_approved 137-58-6 3676
19
Benzocaine Approved 1994-09-7, 94-09-7 2337
20 tannic acid Approved, Nutraceutical

Interventional clinical trials:

(show all 24)

id Name Status NCT ID Phase Drugs
1 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
2 A Trial of Bifocals in Myopic Children With Esophoria Unknown status NCT00000128 Phase 3
3 An Observational Study of Infantile, Acquired Non-accommodative, and Acquired Partially-accommodative Esotropia Completed NCT00310960 Phase 3
4 Bilateral Recession or Unilateral Recession-Resection as Surgery for Infantile Esotropia Completed NCT00304577 Phase 3
5 The Prism Adaptation Study (PAS) Completed NCT00000121 Phase 3
6 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
7 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
8 Eye Muscle Surgery to Treat Congenital Nystagmus Completed NCT00001866 Phase 2
9 Surgery for Esotropia Under Topical Anesthesia Unknown status NCT00993174
10 Long-Term Outcomes in the Treatment of Infantile and Acquired Esotropia With Botulinum Toxin Completed NCT00746304
11 Under-correction in Refractive Accommodative Esotropia Completed NCT01179711
12 Congenital Esotropia Observational Study (CEOS) Completed NCT00000163
13 Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye Completed NCT00001143
14 Binocular Treatment of Amblyopia Before and After Strabismus Surgery Completed NCT01791946
15 Outcome Following Phacoemulsification Versus Small Incision Cataract Surgery (SICS) Completed NCT00821223
16 Bifocal Soft Contact Lenses and Their Effect on Myopia Progression in Children and Adolescents. Completed NCT00214487
17 Early Versus Delayed Surgery for Infantile Esotropia Recruiting NCT01166503
18 Comparison Between Augmented Recession and Posterior Scleral Fixation in Partially Accommodative Esotropia Recruiting NCT02413463
19 Strabismus Surgery and Driving Ability Recruiting NCT02570555
20 IRIS Registry: Intelligent Research in Sight Registry Recruiting NCT02485847
21 Conservative Treatment of Esotropia in Children up to 3 Years Old Active, not recruiting NCT02404324
22 Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia Active, not recruiting NCT01032603
23 Botulinum Toxin Augmented Surgery vs Conventional Surgery in the Management of Large Angle Infantile Esotropia Not yet recruiting NCT03266549
24 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836

Search NIH Clinical Center for Esotropia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Esotropia

Genetic tests related to Esotropia:

id Genetic test Affiliating Genes
1 Esotropia 29

Anatomical Context for Esotropia

MalaCards organs/tissues related to Esotropia:

39
Eye, Brain, Testes, Pituitary, Retina, Thyroid

Publications for Esotropia

Articles related to Esotropia:

(show top 50) (show all 728)
id Title Authors Year
1
Medial and Lateral Rectus Muscle Insertion Distance and Width in Esotropia and Exotropia Patients. ( 28632404 )
2017
2
Acute concomitant esotropia in children. ( 28574208 )
2017
3
Combined resection-recession versus combined recession-retroequatorial myopexy of medial rectus muscles for treatment of near-distance disparity Esotropia. ( 28652690 )
2017
4
A retrospective evaluation of bilateral medial rectus recession for management of accommodative esotropia according to prism-adapted motor response preoperatively. ( 28232011 )
2017
5
Stability and effects of muscle transplantation for very large angle esotropia: A study of 22 patients. ( 28724819 )
2017
6
Esotropia following botulinum toxin type A injection for facial wrinkles. ( 28682151 )
2017
7
Superior and Lateral Rectus Myopexy for Acquired Adult Distance Esotropia: A "One Size Fits All" Surgery. ( 28759293 )
2017
8
Outcome of early surgery in infantile esotropia: Our experience in tertiary care hospital. ( 28924312 )
2017
9
Orbital magnetic resonance imaging is useful in age-related distance esotropia. ( 28601401 )
2017
10
Esotropia with an accommodative component after surgery for infantile esotropia compared to primary accommodative esotropia. ( 28104501 )
2017
11
Stereopsis in patients with refractive accommodative esotropia. ( 28532705 )
2017
12
Evaluation and Management of Acute Acquired Comitant Esotropia in Children. ( 27726470 )
2017
13
Re: Whitman etA al.: Bifocals fail to improve stereopsis outcomes in high AC/A accommodative esotropia (Ophthalmology 2016;123:690-696). ( 27993269 )
2017
14
Comparison of botulinum toxin with surgery for the treatment of acute-onset, comitant esotropia in children. ( 28057455 )
2017
15
Y-Split Recession of the Medial Rectus Muscle as a Secondary and/or Unilateral Procedure in the Treatment of Esotropia with Distance/Near Disparity. ( 28804647 )
2017
16
Postoperative esotropia: initial overcorrection or consecutive esotropia? ( 28430327 )
2017
17
Unilateral Recession-Resection Surgery for Infantile Esotropia: Survival of Motor Outcomes and Postoperative Drifts. ( 28488915 )
2017
18
Novel Eye Movement Disorders in Whipple's Disease-Staircase Horizontal Saccades, Gaze-Evoked Nystagmus, and Esotropia. ( 28744253 )
2017
19
Outcomes after the surgery for acquired nonaccommodative esotropia. ( 28738831 )
2017
20
Transient Esotropia in the Child: Case Report and Review of the Literature. ( 28559837 )
2017
21
Clinical profiles and surgical outcomes of adult esotropia. ( 28774524 )
2017
22
To what extent may Botulinum toxin type A injections be an alternative choice to surgery in infantile esotropia? ( 28362053 )
2017
23
Wright central plication of lateral rectus versus standard medial rectus recession in adult divergence insufficiency esotropia. ( 28315403 )
2017
24
Acquired Adult Onset Cyclic Esotropia in Patients With Myopic Strabismus Fixus and Intraocular Lens Implantation. ( 28692503 )
2017
25
Surgical Treatment of Adult-Onset Esotropia: Characteristics and Outcomes. ( 28092393 )
2017
26
Acute acquired concomitant esotropia and decompensated monofixation syndrome: a sensory-motor status assessment. ( 27521664 )
2016
27
Stepwise increase of hypermetropic correction using contact lenses in intermittent partially accommodative esotropia. ( 26888473 )
2016
28
Infantile esotropia: risk factors associated with reoperation. ( 27799735 )
2016
29
Longitudinal Development of Refractive Error in Children With Accommodative Esotropia: Onset, Amblyopia, and Anisometropia. ( 27116548 )
2016
30
Long-term motor and sensory outcomes after surgery for infantile esotropia. ( 27430111 )
2016
31
Long-Term Changes in Refractive Error and Clinical Evaluation in Partially Accommodative Esotropia after Surgery. ( 27936115 )
2016
32
Horizontal gaze palsy and progressive scoliosis in a patient with congenital esotropia and inability to abduct. A case report. ( 27318526 )
2016
33
Adult-onset chronic divergence insufficiency esotropia: clinical features and response to surgery. ( 26988776 )
2016
34
Essential infantile esotropia with inferior oblique hyperfunction: long term follow-up of 6 muscles approach. ( 28003983 )
2016
35
Surgical Responses of Medial Rectus Muscle Recession in Thyroid Eye Disease-Related Esotropia. ( 26796354 )
2016
36
Acute Acquired Comitant Esotropia in Adults: Is It Neurologic or Not? ( 28018672 )
2016
37
Essential Infantile Esotropia: Postoperative Sensory Outcomes of Strabismus Surgery. ( 27367798 )
2016
38
The long-term outcomes in children who are not compliant with spectacle treatment for accommodative esotropia. ( 27192603 )
2016
39
Cyclic esotropia with development of a high accommodative convergenceA toA accommodation ratio after surgery for intermittent exotropia. ( 27628586 )
2016
40
Bifocals Fail to Improve Stereopsis Outcomes in High AC/A Accommodative Esotropia. ( 26854034 )
2016
41
Atypical presentation of acute acquired comitant esotropia. ( 27597443 )
2016
42
Esotropia Surgery Considering the Angle under General Anesthesia. ( 27532158 )
2016
43
Cyclic esotropia and impaired vision after strabismus surgery. ( 27765448 )
2016
44
Spontaneous Regression of Over-elevation in Adduction Following Esotropia Surgery. ( 26836001 )
2016
45
On surgical planning and innervation in pontine gaze palsy with ipsilateral esotropia. ( 27651233 )
2016
46
Are Bifocals Necessary for Children with High AC/A Esotropia? ( 27012696 )
2016
47
Congenitally Impaired Disparity Vergence in Children With Infantile Esotropia. ( 27159445 )
2016
48
The long-term outcomes in children who are not compliant with spectacle treatment for accommodative esotropia. ( 27312968 )
2016
49
Case 3: A 28-month-old with esotropia and acute lymphoblastic leukemia. ( 27398052 )
2016
50
Variability in Response to Bilateral Medial Rectus Recessions in Infantile Esotropia. ( 27486726 )
2016

Variations for Esotropia

ClinVar genetic disease variations for Esotropia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ANKRD11 NM_013275.5(ANKRD11): c.5317G> T (p.Glu1773Ter) single nucleotide variant Pathogenic rs1114167291 GRCh37 Chromosome 16, 89347633: 89347633

Expression for Esotropia

Search GEO for disease gene expression data for Esotropia.

Pathways for Esotropia

GO Terms for Esotropia

Biological processes related to Esotropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 inner ear morphogenesis GO:0042472 8.96 COL11A1 SOBP
2 skeletal system morphogenesis GO:0048705 8.62 ANKRD11 COL11A1

Sources for Esotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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