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MCID: ESS002

Essential Hypertension malady
119 drugs, 397 genes, 14 tissues, 951 related diseases, 26 phenotypes, 1269 articles, clinical trials.

Summaries for Essential Hypertension

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44Wikipedia, 33OMIM, 22MalaCards
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Wikipedia: Essential hypertension (also called primary hypertension or idiopathic hypertension) is the form of...44 more...

MalaCards: Essential Hypertension, also known as essential hypertension nos (disorder), is related to hypertension and aldosteronism. An important gene associated with Essential Hypertension is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are Neuroactive ligand-receptor interaction and Calcium signaling pathway. The drugs bendroflumethiazide and diltiazem and the compounds lipid and fatty acid have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and smooth muscle, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

OMIM: 145500

Aliases & Descriptions for Essential Hypertension

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6Disease Ontology, 33OMIM, 32Novoseek , 43UMLS, 40SNOMED-CT, 19ICD9CM, 27NCIt
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Aliases & Descriptions:

essential hypertension 6 32 43
essential hypertension nos (disorder) 6
unspecified essential hypertension 6
essential hypertension (disorder) 6
essential hypertension nos 6
hypertension, essential 33
idiopathic hypertension 6
primary hypertension 6
hypertensive disease 43

External Ids:

ICD9CM19 401, 401.9
SNOMED-CT40 155296003, 194757006, 59621000 194760004, 266228004, more
NCIt27 C3478

Related Diseases for Essential Hypertension

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13GeneCards, 14GeneDecks
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Disease types for essential hypertension family:

hypertension, essential 1 hypertension, essential 2
hypertension, essential 3 hypertension, essential 4
hypertension, essential 5 hypertension, essential 6
hypertension, essential 7 hypertension, essential 8

Diseases related to essential hypertension by text searches and GeneDecks gene sharing:

(show top 50)    (show all 940)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension44.8REN, MYLK, KCNMB1, HYT3, GNB3, CYP11B2
2aldosteronism41.4REN, RETN, KISS1, SERPINE1, NAGLU, VEGFA
3insulin resistance38.4LEPR, IRS1, INS, PTPN1, PPARGC1A, SOD1
4type 2 diabetes mellitus37.7COG2, RETN, VWF, GCK, GCGR, SELE
5obesity36.6COG2, REN, RETN, KISS1, VWF, GCK
6atherosclerosis36.3COG2, REN, RETN, KISS1, VWF, GCK
7pre-eclampsia34.9REN, RETN, KISS1, VWF, SELE, SELL
8nephropathy34.8COG2, REN, RETN, VWF, GCK, SELE
9ischemic heart disease34.7COG2, RETN, SELP, SERPINE1, LPA, LPL
10hyperaldosteronism34.7REN, CLCNKB, KCNJ1, KCNJ5, SCNN1G, INS
11neuronitis34.6PIK3C2B, REN, RETN, KISS1, VWF, GCK
12diabetes mellitus34.3COG2, REN, RETN, VWF, GCK, GCGR
13congestive heart failure34.1COG2, REN, GCA, UTS2, CDKN3, MME
14cerebritis33.8COG2, REN, VWF, GCK, SELE, SELP
15coronary heart disease33.7COG2, RETN, VWF, SELE, SELL, SELP
16cholesterol33.0PIK3C2B, COG2, REN, RETN, VWF, GCK
17proteinuria33.0COG2, REN, VWF, SELL, SELP, SERPINC1
18atrial fibrillation32.9REN, RETN, VWF, SELE, SELP, SERPINC1
19fatty liver disease32.7COG2, RETN, SERPINE1, LPL, LIPC, LEP
20high blood pressure32.7COG2, REN, RETN, LPL, BGLAP, LEP
21homocysteine32.5COG2, REN, RETN, VWF, GCK, SELE
22blindness32.4COG2, REN, VWF, SELE, SELP, SERPINC1
23glucose intolerance32.1RETN, GCK, GCGR, SERPINE1, LPL, LIPC
24eclampsia32.1REN, KISS1, VWF, SELE, SELL, SELP
25hyperuricemia31.7REN, GCK, SELP, SERPINE1, LPL, LIPC
26apnea31.7REN, RETN, VWF, SELE, SELP, SERPINE1
27alcoholism31.5IL1RN, GPT, HTR2A, ALDH2, ALDH9A1, HMGCR
28myocardial infarction31.5MMP2, APOB, APOE, TNFSF4, OLR1, LTA
29retinol binding protein31.3RETN, NAGLU, LPA, LIPC, LEP, B2M
30ischemia31.2COG2, REN, RETN, VWF, GCK, SELE
31carotid artery disease31.2COG2, SELE, LPA, APOA1, APOA2, APOB
32liddle syndrome31.1REN, SCNN1A, SCNN1B, SCNN1G, IGF1, HSD11B2
33sleep apnea31.0RETN, LEP, NPPB, NPY, KNG1, ADRB2
34renovascular hypertension30.9REN, ACE, AGTR1, AHSP, NPPA, ADM
35pancreatitis30.9REN, RETN, KISS1, VWF, GCK, GCGR
36panic disorder30.5NAGLU, CLU, AVPR1A, IL10, APOE, IGF1
37gitelman syndrome30.4REN, BSND, CLCNKB, KCNJ1, IGF1, HMOX1
38pulmonary hypertension30.3UTS2, TPH1, PTGIS, DDAH2, NOS2, NOS3
39hepatitis30.2COG2, REN, RETN, VWF, GCK, GCGR
40malignant hypertension30.2REN, VWF, TRPC3, TRPC6, CYP1A1, EDN1
41uremia30.1REN, RETN, VWF, SELL, SERPINC1, SERPINE1
42hypercholesterolemia30.0COG2, RETN, VWF, SELE, SELP, SERPINF2
43hypertensive nephropathy30.0NAGLU, VEGFA, INS, AMBP, ALB, SST
44thrombophilia30.0VWF, SELE, SELP, SERPINC1, SERPINF2, SERPINE1
45acromegaly29.9RETN, SERPINC1, SERPINE1, NAGLU, VEGFA, LPA
46portal hypertension29.8RETN, UTS2, GPT, HTR2A, F2, ALB
47renal hypertension29.8REN, KLKB1, EDN1, ACE, KNG1, ADM
48carotid intimal medial thickness29.7SERPINE1, LPL, MTHFR, CETP, INS, IL6
49morbid obesity29.7RETN, LPL, LEP, LEPR, INS, ADRB3
50cerebral infarction29.4COG2, VWF, SELP, SERPINC1, SERPINE1, VEGFA

Graphical network of the top 20 diseases related to essential hypertension:



Graphical network of diseases related to essential hypertension

Clinical Features for Essential Hypertension

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33OMIM
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Clinical features from OMIM: 145500

Drugs & Therapeutics for Essential Hypertension

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for essential hypertension

Drug clinical trials:

Search ClinicalTrials for essential hypertension

Search NIH Clinical Center for essential hypertension

Search CenterWatch for essential hypertension

Inferred drug relations via UMLS/NDF-RT:

43 28 [cv490] antihypertensives,other, acebutolol, acebutolol hydrochloride, amiloride, amiloride hydrochloride, amlodipine, amlodipine besylate, atenolol, benazepril, benazepril hydrochloride, bendroflumethiazide, benzthiazide, bepridil, bepridil hydrochloride, betaxolol, betaxolol hydrochloride, bisoprolol, bisoprolol fumarate, bumetanide, candesartan, candesartan cilexetil, carteolol, carteolol hydrochloride, carvedilol, carvedilol phosphate, chlorothiazide, chlorothiazide sodium, chlorthalidone, clonidine, clonidine hcl pwdr [va product], clonidine hydrochloride, coenzyme q10, cyclothiazide, deserpidine, diltiazem, diltiazem hcl, diltiazem hydrochloride, diltiazem maleate, ditiaz, dong quai, doxazosin, doxazosin mesylate, eplerenone, eprosartan, eprosartan mesylate, esmolol, esmolol hydrochloride, ethacrynate sodium, ethacrynic acid, felodipine, fish oil, fosinopril, fosinopril sodium, furosemide, garlic oil, guanabenz, guanabenz acetate, guanadrel, guanadrel sulfate, guanethidine, guanethidine monosulfate, guanfacine, guanfacine hydrochloride, hydrochlorothiazide, hydroflumethiazide, indapamide, irbesartan, isradipine, lisinopril, losartan, losartan potassium, methyclothiazide, methyldopa, methyldopate hydrochloride, metolazone, metoprolol, metoprolol succinate, metoprolol tartrate, mibefradil, mibefradil dihydrochloride, moexipril, moexipril hydrochloride, nadolol, nicardipine, nicardipine hydrochloride, nifedipine, nisoldipine, olmesartan, olmesartan medoxomil, penbutolol, penbutolol sulfate, perindopril, perindopril erbumine, pindolol, polythiazide, prazosin, prazosin hydrochloride, propranolol, propranolol hydrochloride, quinapril, quinapril hydrochloride, quinethazone, ramipril, reserpine, spironolactone, spironolactone pwdr [va product], telmisartan, terazosin, terazosin hydrochloride, timolol, timolol hemihydrate, timolol maleate, torsemide, trandolapril, triamterene, trichlormethiazide, valsartan, verapamil, verapamil hydrochloride

Genetic Tests for Essential Hypertension

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Anatomical Context for Essential Hypertension

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22MalaCards
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MalaCards organs/tissues related to essential hypertension:

22
Brain, Heart, Smooth muscle, Skeletal muscle, Kidney, Liver, Adrenal gland, Skin, Placenta, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

Phenotypes for genes affiliated with Essential Hypertension

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25MGI
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MGI Mouse Phenotypes related to essential hypertension:

25 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1homeostasis/metabolism phenotypeMP:000537615.5REN, RETN, KISS1, VWF, GCK, GCGR
2renal/urinary system phenotypeMP:000536714.2REN, KISS1, GCK, SELP, BSND, NAGLU
3growth/size phenotypeMP:000537813.9REN, KISS1, GCK, GCGR, SELE, SELP
4mortality/agingMP:001076813.8REN, KISS1, VWF, GCK, GCGR, SELE
5behavior/neurological phenotypeMP:000538613.6REN, SELE, SELP, BSND, NAGLU, LMX1A
6cardiovascular system phenotypeMP:000538513.1REN, VWF, SELE, SELL, SELP, SERPINC1
7immune system phenotypeMP:000538712.4REN, VWF, SELL, SELP, NAGLU, VDR
8respiratory system phenotypeMP:000538812.2SELL, SELP, LPL, SCNN1A, SCNN1B, SCNN1G
9no phenotypic analysisMP:000301212.1PIK3C2B, VEGFA, VCAM1, LMX1A, RAMP2, KDM5B
10adipose tissue phenotypeMP:000537512.1RETN, GCGR, SERPINE1, LPL, BDKRB2, KCNJ11
11nervous system phenotypeMP:000363112.1REN, KISS1, VWF, SELP, SERPINC1, BSND
12endocrine/exocrine gland phenotypeMP:000537912.0KISS1, SELL, BDKRB2, KCNJ11, LDLR, CD40LG
13muscle phenotypeMP:000536912.0REN, VEGFA, LPL, MYLK, RAMP2, CLU
14hematopoietic system phenotypeMP:000539711.0BSND, BDKRB2, KCNJ1, LAX1, XCL1, AVPR1A
15integument phenotypeMP:001077111.0PIK3C2B, KISS1, SELP, LMX1A, RAMP2, PBX1
16liver/biliary system phenotypeMP:000537010.8RETN, GCK, SERPINC1, VEGFA, LPL, RAMP2
17normal phenotypeMP:000287310.6REN, GCGR, SELE, VEGFA, MYLK, PBX1
18skeleton phenotypeMP:000539010.5NAGLU, VEGFA, VDR, LMX1A, BMP6, PBX1
19digestive/alimentary phenotypeMP:000538110.5KISS1, VWF, VEGFA, VDR, MYLK, PBX1
20reproductive system phenotypeMP:000538910.4REN, KISS1, GCGR, VEGFA, VDR, LMX1A
21embryogenesis phenotypeMP:000538010.2SERPINC1, LMX1A, RAMP2, PBX1, ATP1A2, CD247
22cellular phenotypeMP:000538410.1VWF, SELE, SELL, SELP, NAGLU, VEGFA
23hearing/vestibular/ear phenotypeMP:00053779.3BSND, NAGLU, VDR, LMX1A, PBX1, KCNMB1
24other phenotypeMP:00053959.2CLU, PBX1, SCNN1G, LEPR, LDLR, CD40LG
25vision/eye phenotypeMP:00053919.0SELE, SELP, SERPINC1, NAGLU, VEGFA, LEP
26tumorigenesisMP:00020069.0SELL, SERPINE1, LEP, LEPR, B2M, ATP2A2

Publications for genes affiliated with Essential Hypertension

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35PubMed
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Articles related to essential hypertension:

(show top 50)    (show all 1269)
idTitleAuthorsYearAffiliating Genes
1Association between single nucleotide polymorphisms (SNPs) at the promoter of adiponectin gene and essential hypertension in Chines e Korean and Han of Yanbian region]. (21377959)Zhang Z.B.... Meng F.P.2011ADIPOQ
2Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension. (20235788)Filigheddu F.... Glorioso N.2010ADRB2, GNB3, ADRB1
3Gly460Trp polymorphism of the ADD1 gene and essential hypertension in an Indian population: A meta-analysis on hypertension risk. (20838486)Ramu P.... Adithan C.2010ADD1
4Combination of an ACE inhibitor and indapamide improv es blood pressure control, but attenuates the beneficial effects of ACE inhibit ion on plasma adiponectin in patients with essential hypertension. (19789415)Huang S.S.... Chen J.W.2009ACE, ADIPOQ
5WNK4 polymorphisms and essential hypertension in the Uyghur population. (19330605)Lu M.... Jin L.2009WNK4
6Analysis of renin-angiotensin aldosterone system gene polymorphisms in malaysian essential hypertensive and type 2 diabetic subjects. (19243623)Ramachandran V.... Shamsudin N.2009REN, AGT, ADD1
7Association of insertion/deletion polymorphism of angiotensin-converting enzyme gene with essential hypertension and type 2 diabetes mellitus in Malaysian subjects. (19126661)Ramachandran V.... Mohd Jas R.2008ACE
8Impact of the metalloproteinase-9/tissue inhibitor of metalloproteinase-1 system on large arterial stiffness in patients with essential hypertension. (18049028)Tan J.... Yang Z.2007MMP9, TIMP1
9Association of thiazide-sensitive Na+-Cl* cotransporter gene polymorphisms with the risk of essential hypertension (18067089)Zhan Y.Y.... Huang J.2007SLC12A3
10Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. (17547476)Robinson D.M.... Lyseng-Williamson K.A.2007ACE
11Effects of valsartan and indapamide on plasma cytokines in essential hypertension. (17062919)Xie Q.Y.... Yang T.L.2006CCL2
12Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension. (16875975)Rubattu S.... Stella P.2006NPR1, NPPB, NPPA
13Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity. (17066056)Felder R.A.... Jose P.A.2006AGTR1, GRK4
14A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study. (16081343)Jiang S.... Xu X.2005ACE, MTHFR
15A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril. (15788353)He H.... Hu Y.H.2005ACE, CMA1
16Microsatellite marker AGAT of the mineralocorticoid receptor gene is associated with plasma renin activity in patients with essential hypertension (16446868)Munoz-Brauning C.R.... Fardella C.E.2005NR3C2
17G-protein beta-3 subunit gene 825C>T dimorphism is associated with left ventricular hypertrophy but not essential hypertension. (15614196)Mahmood M.S.... Frossard P.M.2005GNB3
18Serum interleukin-15 concentration in patients with essential hypertension. (16109314)Kaibe M.... Ogihara T.2005IL15
19Ramipril/felodipine extended-release fixed-dose combi nation: a review of its use in the management of essential hypertension. (16114982)CvetkoviA8 R.S.... Plosker G.L.2005ACE
20Possible involvement of urotensin II in essential hypertension (15506483)Ikeda K.... Tojo K.2004UTS2
21An association study in essential hypertension using functional polymorphisms in lymphotoxin-alpha gene. (15533732)Nakayama T.... Kokubun S.2004LTA
22Association analysis of polymorphisms at the interleukin-1 locus in essential hypertension. (11840488)Lin R.C.... Morris B.J.2002IL1B, IL1A, IL1RN
23Effects of terazosine and atenolol on serum lipids in essential hypertension (12448067)Bur A.... Hirschl M.M.2002ACE
24Enalapril acts through release of nitric oxide in patients with essential hypertension. (11725911)Jain S.... Kumari S.2001KNG1
25A comparative evaluation of therapeutic effects of once a day dose of losartan potassium versus enalapril maleate in mild to moderate essential hypertension. (12022207)Neki N.S.... Arora P.2001ACE
26Role of the angiotensinogen gene for essential hypertension (10713906)Brand E.... Sharma A.M.2000AGT
27Association analyses of endothelial nitric oxide synthase gene polymorphisms in essential hypertension. (10981549)Benjafield A.V.... Morris B.J.2000NOS3
28Transvascular albumin leakage and forearm vasodilatation to acetylcholine in essential hypertension. (10777029)Pedrinelli R.... Mariani M.2000ALB
29Renin inhibition improves pressure natriuresis in essential hypertension. (11004211)van Paassen P.... Navis G.2000REN
30Amylin innocent in essential hypertension? (10491767)Young A.... Hall J.1999IAPP
31Screening for the Gly40Ser mutation in the glucagon receptor gene among patients with type 2 diabetes or essential hypertension in Taiwan. (10090412)Huang C.N.... Chuang L.M.1999GCGR
32825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension. (10526907)Jacobi J.... Schmieder R.E.1999GNB3
33Contribution of angiotensin I converting enzyme gene polymorphism and angiotensinogen gene polymorphism to blood pressure regulation in essential hypertension. (9524045)Mondorf U.F.... Lenz T.1998ACE, AGT
34Effects of plendil on serum oxygen free radicals and insulin resistance in patients with essential hypertension (10322704)Zhu X.... Ou S.1998INS
35Does the renin-angiotensin system determine the renal and systemic hemodynamic response to sodium in patients with essential hypertension? (8567042)van Paassen P.... de Jong P.E.1996REN
36Differing metabolism and bioactivity of atrial and brain natriuretic peptides in essential hypertension. (8613267)Pidgeon G.B.... Frampton C.1996NPPB, NPPA
37Microalbuminuria and erythrocyte sodium-hydrogen exchange in essential hypertension. (7737737)Giampietro O.... Pedrinelli R.1995INS
38Predictors for hypertensive nephropathy: results of a 6-year follow-up study in essential hypertension. (7622857)Schmieder R.E.... SchAochinger H.1995NAGLU
39The effect of radon baths at the Khmel'nik health re sort on the central hemodynamic indices and calcium-regulating hormones in pati ents with essential hypertension (8630822)KorchinskiA- V.S.1995CALCA
40Insulin resistance in essential hypertensive patients with impaired glucose tolerance. (8593759)Sekiya M.... Kamada T.1995ACE, INS
41Association analysis of a polymorphism of the angiotensinogen gene with essential hypertension in Japanese. (7932516)Kamitani A.... Ogihara T.1994AGT
42Impaired insulin clearance in essential hypertension. (7911838)Swislocki A.L.1994SST, INS
43Neuropeptide-Y Y1 receptor gene polymorphism: cross-sectional analyses in essential hypertension and obesity. (7902088)Herzog H.... Shine J.1993NPY, NPY1R
44Are free radicals involved in the pathobiology of human essential hypertension? (8225035)Kumar K.V.... Das U.N.1993SOD1
45Octreotide, a somatostatin analog, reduces insulin se cretion and increases renal Na+ excretion in lean essential hypertensive patien ts. (8507446)Ferri C.... Balsano F.1993SST, INS
46The effect of angiotensin II on platelet intracellular free magnesium and calcium ionic concentrations in essential hypertension. (8390527)Touyz R.M.... Schiffrin E.L.1993EDN1
47Pulmonary arterial brain natriuretic peptide concentration and cardiopulmonary hemodynamics during exercise in patients with essential hypertension. (1461132)Kohno M.... Takeda T.1992NPPB
48Is atrial natriuretic peptide-guanosine 3',5' cyclic monophosphate coupling a determinant of urinary sodium excretion in essential hypertension? (1316400)Sagnella G.A.... MacGregor G.A.1992NPPA
49Dissociation of plasma atrial natriuretic peptide responses to upright posture and furosemide administration in patients with normal-, low renin essential hypertension and primary aldosteronism. (1832596)Sergev O.... GlA!z E.1991REN, NPPA
50Effects of a novel renin inhibitor in patients with essential hypertension. (1691375)Bursztyn M.... Gavras H.1990REN

Expression for genes affiliated with Essential Hypertension

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Essential Hypertension

Pathways for genes affiliated with Essential Hypertension

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20KEGG, 34PharmGKB, 36QIAGEN, 37R&D Systems, 41Thomson Reuters, 10EMD Millipore
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Pathways related to essential hypertension according to GeneDecks:

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idPathwayScoreTop Affiliating Genes
1Neuroactive ligand-receptor interaction2012.7GCGR, BDKRB2, LEP, LEPR, P2RY2, AVPR1A
2Calcium signaling pathway2012.6MYLK, BDKRB2, AVPR1A, ATP2B2, ATP2A2, ATP2B1
3Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics3412.2REN, CMA1, BDKRB2, MME, CYP11B2, NR3C2
4Metabolic pathways2012.0PIK3C2B, GCK, NAGLU, LIPC, UCK2, MTHFR
5Activation of PKA through GPCR3611.8GCGR, BMP6, UTS2, GYS1, INSR, IL6
6Aldosterone-regulated sodium reabsorption2011.8KCNJ1, SCNN1A, SCNN1B, ATP1A2, ATP1A1, ATP1B1
7Sympathetic Nerve Pathway (Neuroeffector Junction)3411.7CACNA1B, DDC, TH, NPY, NPY1R, SLC6A2
8ACE Inhibitor Pathway, Pharmacodynamics3411.6CMA1, BDKRB2, MME, NR3C2, ACE2, AGTR1
9AMPK Enzyme Complex Pathway3611.6LEP, GYS1, IRS1, IRS2, INS, INSR
10Vascular smooth muscle contraction2011.5MYLK, RAMP2, KCNMB1, KCNMA1, AVPR1A, GNAS
11Activation of cAMP-Dependent PKA3611.5GCGR, BMP6, UTS2, CLCNKB, SCNN1A, SCN7A
12cAMP Pathway3611.5GCGR, BMP6, UTS2, SCNN1A, SCN7A, SCNN1B
13Salivary secretion2011.4KCNMA1, ATP1A2, ATP2B2, ATP1A1, ATP2B1, ATP1B1
14PPAR signaling pathway2011.4LPL, APOA1, APOA2, APOC3, FABP3, CYP4A11
15Signaling Involved in Cardiac Hypertrophy3611.3MYLK, JUN, ITGA9, ITGAM, IRS1, INSR
16Adipocytokine signaling pathway2011.3LEP, LEPR, IRS1, IRS2, MAPK10, TNF
17Renin-angiotensin system2011.2REN, CMA1, MME, ACE, ACE2, AGT
18Endothelin-1 Signaling Pathway3610.9BMP6, CD2, INSR, IL10, IL12B, IL1A
19Intracellular Calcium Signaling3610.8BMP6, UTS2, ATP2B2, ATP2A2, ATP2B1, INSR
20Statin Pathway, Pharmacodynamics3410.7LPL, LIPC, LDLR, LCAT, APOA1, APOB
21Chagas disease (American trypanosomiasis)2010.6SERPINE1, BDKRB2, JUN, CD247, IL10, IL12B
22Akt Signaling3610.6UTS2, CD2, ITGA9, ITGAM, GYS1, IRS1
23Type II diabetes mellitus2010.6GCK, KCNJ11, IRS1, IRS2, INS, MAPK10
24RAR-Gamma-RXR-Alpha Degradation3610.5CD2, IL15, MAPK10, PF4, LTA, TGFB3
25Blood Coagulation Signaling Pathways3710.4VWF, SERPINC1, SERPINF2, SERPINE1, GP5, F5
26Rho Family GTPases3610.2MYLK, BMP6, UTS2, JUN, CD2, ITGA9
27Molecular Mechanisms of Cancer3610.1BMP6, UTS2, JUN, CD2, ITGA9, ITGAM
28STAT3 Pathway3610.1BMP6, CD2, IL10, IL12B, IL15, IL1A
29MIF Mediated Glucocorticoid Regulation3610.1BMP6, CD2, IL10, IL12B, IL15, IL1A
30MIF Regulation of Innate Immune Cells3610.0BMP6, JUN, CD2, IL10, IL12B, IL15
31Transcription_Role of VDR in regulation of genes involved in osteoporosis4110.0VDR, BGLAP, JUN, IL1A, IL1B, IL6
32Transcription Role of VDR in regulation of genes involved in osteoporosis1010.0VDR, BGLAP, JUN, IL1A, IL1B, IL6
33Immune response IL-1 signaling pathway109.9SERPINE1, JUN, IL1A, IL1B, IL1R1, IL6
34p38 Signaling369.9BMP6, UTS2, CD2, INSR, IL10, IL12B
35Immune response_IL-1 signaling pathway419.9SERPINE1, JUN, IL1A, IL1B, IL1R1, IL6
36PAK Pathway369.9MYLK, BMP6, UTS2, CD2, IL10, IL12B
37all-trans-Retinoic Acid Signaling in Brain369.8BMP6, CD2, IL10, IL12B, IL15, IL1A
38Leishmaniasis209.8JUN, ITGAM, IL10, IL12B, IL1A, IL1B
39Tec Kinases Signaling369.8BMP6, UTS2, CD2, ITGA9, ITGAM, INSR
40PEDF Induced Signaling369.7BMP6, CD2, IL10, IL12B, IL15, IL1A
41Toxoplasmosis209.7LDLR, CD40LG, IL10, IL12B, MAPK10, CCR5
42ERK Signaling369.6MYLK, BMP6, UTS2, CD2, ITGA9, ITGAM
43Malaria209.5SELE, SELP, VCAM1, CD40LG, IL10, IL1B
44Antioxidant Action of Vitamin-C369.4BMP6, UTS2, JUN, CD2, IL10, IL12B
45Rheumatoid arthritis209.4VEGFA, JUN, MMP3, IL15, IL1A, IL1B
46MAPK Family Pathway369.2BMP6, UTS2, JUN, CD2, IL10, IL12B
47TGF-Beta Pathway369.1BMP6, UTS2, JUN, CD2, IL10, IL12B
48MAPK Signaling368.9BMP6, UTS2, JUN, ITGA9, ITGAM, INSR
49Cytokine-cytokine receptor interaction208.7VEGFA, LEP, LEPR, XCL1, CD40LG, IL10
50JAK-STAT Pathway368.6BMP6, UTS2, JUN, CD2, INSR, IL10

Compounds for genes affiliated with Essential Hypertension

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
See all sources

Compounds related to essential hypertension according to GeneDecks:

(show top 50)    (show all 610)
idCompoundScoreTop Affiliating Genes
1lipid32 17.0PIK3C2B, COG2, RETN, GCK, SELE, SERPINF2
2fatty acid32 12.8COG2, RETN, GCK, GCGR, BLZF1, CLU
3dopamine32 9 18 9 15.6REN, SELE, NAGLU, BMP6, CLU, KCNJ5
4cgmp32 12.5REN, GCA, LPA, MYLK, BDKRB2, KCNJ5
5superoxide32 18 13.1SELL, NAGLU, LPA, VCAM1, LIPC, BLZF1
6telmisartan32 9 9 13.9COG2, REN, LEP, INS, ALB, PPARG
7phenylephrine32 9 18 9 14.9LPL, UTS2, KCNMA1, LEP, APOB, GNAI1
8haloperidol32 34 9 9 14.9REN, KCNJ5, CHGA, IL1R1, GPT, HTR2A
9threonine32 11.8MYLK, BDKRB2, BAIAP2L1, GNAI1, GNAS, CYP11B2
10morphine32 9 9 13.8KCNJ5, MME, IL1RN, MAPK10, CCR5, CACNA1B
11progesterone32 42 9 18 9 15.8KISS1, GCK, CLU, PBX1, SCNN1G, LEPR
12acth32 11.8REN, PBX1, LEP, LEPR, AVPR1A, MME
13lisinopril32 9 18 9 14.8REN, VEGFA, BDKRB2, MME, ALB, SHBG
14perindopril32 34 9 9 14.8REN, VWF, SERPINE1, NAGLU, VEGFA, ALB
15estrogen32 11.8COG2, RETN, KISS1, VWF, SERPINC1, SERPINE1
16sodium nitroprusside32 11.5REN, VWF, BMP6, BDKRB2, KCNJ5, KCNMA1
17ethanol32 34 9 18 9 15.5LPA, LIPC, CLU, BDKRB2, KCNMA1, LEPR
18pge232 11.5REN, SELE, VCAM1, BDKRB2, KCNMA1, LDLR
19isoproterenol32 9 9 13.5SELL, KCNMA1, CHGA, P2RY2, ITGAM, FKBP1B
20serine32 11.4VWF, GCK, SELE, SELL, SERPINC1, SERPINF2
21thiazide32 11.4REN, LPL, VDR, BGLAP, KCNMA1, SCNN1A
22streptozotocin32 11.3GCK, NAGLU, LPL, CHGA, LDLR, CETP
23candesartan32 9 9 13.3REN, SELP, SERPINE1, VEGFA, BDKRB2, MMP2
24androstenedione32 18 12.2COG2, REN, PBX1, LEP, LEPR, INS
25phospholipid32 11.2COG2, VWF, LPL, LIPC, BLZF1, CLU
26probucol32 9 9 13.2SELE, LPL, VCAM1, LIPC, LDLR, LCAT
27adenylate32 11.2VWF, GCK, GCGR, SELE, SELP, SERPINC1
28polyethylene glycol32 11.0SELE, SERPINC1, INSR, APOA1, APOE, HP
29iloprost32 42 9 9 14.0SELE, SELP, SERPINC1, VCAM1, F3, GNAS
30nifedipine32 9 9 12.9REN, SELE, SERPINE1, NAGLU, BMP6, BGLAP
31rosiglitazone32 9 18 9 13.9COG2, RETN, SELE, SERPINE1, LPA, LPL
32pioglitazone32 9 9 12.9COG2, RETN, VEGFA, LPL, VCAM1, LIPC
33thapsigargin32 42 11.8SERPINE1, MYLK, UTS2, BLZF1, BDKRB2, KCNMA1
34clozapine32 34 9 9 13.7LEP, FMO3, IL10, IL1R1, HTR2A, GNB3
35malondialdehyde32 10.7COG2, NAGLU, LPA, GSTM1, GSTT1, APOA2
36digoxin32 42 34 9 18 9 15.6REN, ATP1A2, ATP1A1, ATP1B1, IL10, F2
37diltiazem32 9 9 12.6LDLR, CACNA1B, HMGCR, CYP2C9, KRIT1
38estrone32 9 18 9 13.1LPL, BGLAP, LEP, IRS1, APOB, IGF1
39dihydrotestosterone32 9 18 9 13.1SERPINE1, LPL, VDR, BMP6, CLU, BGLAP
40prednisolone32 9 9 12.1VWF, SELL, VCAM1, BMP6, BGLAP, CDKN3
41mifepristone32 42 9 9 12.9JUN, MMP3, IRS1, IRS2, IL1B, CCL2
42ribonucleic acid32 9.9BMP6, BLZF1, CLU, LEPR, CHGA, ATP2A2
43polysaccharide32 9.9SELE, SELL, SELP, SERPINC1, SERPINF2, LPL
44clopidogrel32 34 9 18 9 13.5SERPINC1, CD40LG, HMGCR, TBXA2R, CYP2C9, PPBP
45lactate32 9.4VWF, GCK, SELE, SELL, SELP, NAGLU
46vegf32 9.4REN, RETN, VWF, SELE, SELP, SERPINC1
47neopterin32 9.3NAGLU, CHIT1, B2M, CD40LG, IL10, IL1A
48actinomycin d32 8.6RETN, SELE, SERPINE1, VEGFA, LPA, VDR
49ascorbic acid32 18 9.3VDR, BGLAP, LDLR, LCAT, CD40LG, ITGAM
50tamoxifen32 34 9 9 11.3SELE, SERPINC1, VEGFA, LPL, VDR, VCAM1

GO Terms for genes affiliated with Essential Hypertension

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Sources:
12Gene Ontology
See all sources

Cellular components related to essential hypertension according to GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588614.5GP5, HSPG2, CACNA1B, CAPN10, CAT, CALCRL
2integral to plasma membraneGO:00588713.5GP5, TNFRSF4, TNFSF4, DRD1, DRD3, DRD5
3cytosolGO:00582911.4PPARG, NR3C1, PNMT, NOS1, NOS2, NOS3
4extracellular regionGO:00557610.9CREG1, TOR2A, TIMP1, TGFB1, TGFB3, PRSS8
5neuronal cell bodyGO:04302510.9CYP19A1, SST, TGFB1, TGFB3, SOD1, ADCY10
6high-density lipoprotein particleGO:03436410.8PON1, APOE, APOA2, APOA1, CETP, SAA1
7extracellular matrixGO:03101210.8PLAT, TGFB3, DPT, PRELP, SOD1, SOD3
8caveolaGO:00590110.7ADRB2, NOS3, PTGIS, DRD1, HMOX1, INSR
9cell surfaceGO:00998610.5SPTB, PPFIA4, PLAT, ABCB1, ACE2, THBD
10external side of plasma membraneGO:00989710.2CCR5, ICAM1, HLA-DRB1, TNF, TNFRSF4, ACE
11platelet alpha granule lumenGO:03109310.1PF4, EGF, TIMP1, TGFB1, TGFB3, KNG1
12extracellular spaceGO:0056158.9LEP, IL12B, IL15, IL1A, IL1B, IL1RN

Biological processes related to essential hypertension according to GeneDecks:

(show top 50)    (show all 58)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428113.4CPT2, CYP2J2, CYP4F2, CYP19A1, CYP17A1, CYP11B1
2regulation of blood pressureGO:00821712.6NPY1R, NPR2, NPR1, NPPC, NPPB, NPPA
3G-protein coupled receptor signaling pathwayGO:00718612.4EDNRA, EDN1, SST, TBXA2R, PTGER3, AGT
4elevation of cytosolic calcium ion concentrationGO:00720412.2TRPC6, TBXA2R, EDN1, EDN2, EDNRA, AGTR1
5cell-cell signalingGO:00726711.8AGT, EDN1, LTA, NR5A1, POMC, ADRA1D
6regulation of vasoconstrictionGO:01922911.8ECE1, NPPC, AGTR1, AGT, ACE2, ACE
7transmembrane transportGO:05508511.7SLC2A4, SLC8A1, SLC9A3, SLC12A1, SLC12A3, SLC9A1
8activation of adenylate cyclase activityGO:00719011.6ADRB1, ADRB3, ADORA2A, ADRB2, EDNRA, DRD5
9adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00718911.6ADRB1, ADRB3, ADORA2A, ADRB2, PTGER2, DRD5
10positive regulation of renal sodium excretionGO:03581511.5ADORA2A, KNG1, NPR1, NPPB, AGT, EDN1
11negative regulation of blood pressureGO:04577611.5ADIPOQ, ADORA1, NPY, DRD5, DRD3, CALCA
12positive regulation of vasodilationGO:04590911.4ADM, ADRB2, NPPC, AGTR2, NOS3, NOS1
13cell surface receptor signaling pathwayGO:00716611.4EDNRB, AGER, AGTR2, PRL, NPPB, NPR1
14cholesterol metabolic processGO:00820311.4APOB, APOC3, APOE, CAT, TNFSF4, CYP11A1
15regulation of vasodilationGO:04231211.4NPR1, NPPB, AGTR1, ACE2, ACE, P2RY2
16heart developmentGO:00750711.3EDN1, EDNRA, TH, NPPB, ECE1, ADM
17excretionGO:00758811.3HMOX1, AGT, NPHS2, NEDD4L, GUCA2B, SCNN1G
18lipoprotein metabolic processGO:04215711.3APOC3, APOE, ALB, HSPG2, OLR1, APOB
19response to drugGO:04249311.2PRSS8, TGFB1, ABCB1, EDN1, LTA, NOS3
20cholesterol homeostasisGO:04263211.2ACSM3, ACSM1, APOE, APOC3, APOB, APOA2
21xenobiotic metabolic processGO:00680511.2CYP11A1, CYP11B1, CYP17A1, CYP19A1, CYP4F2, CYP2J2
22cGMP biosynthetic processGO:00618211.2NPR2, NPR1, NPPC, NPPB, NPPA, GUCA2B
23regulation of blood vessel sizeGO:05088011.1NOS3, NPPA, NPPB, NPPC, NPR1, NTS
24negative regulation of smooth muscle cell proliferationGO:04866211.1ADIPOQ, NPR1, NPPB, NOS3, PPARG, HMOX1
25negative regulation of inflammatory responseGO:05072811.1NLRP3, ADRB2, ADORA2A, ADA, ADIPOQ, PTGER4
26response to glucocorticoid stimulusGO:05138411.0HSD11B2, TNF, PTGDS, PLAT, SLC9A3, ADM
27regulation of sodium ion transportGO:00202811.0SLC9A3, SLC8A1, TGFB1, NOS3, NOS1, ATP1A1
28reverse cholesterol transportGO:04369111.0APOE, APOC3, APOA2, APOA1, CETP, LCAT
29blood coagulationGO:00759611.0KNG1, SLC8A1, CSK, SOD1, PROCR, PRCP
30lipid metabolic processGO:00662911.0APOA2, APOB, APOC3, APOE, ALB, HSPG2
31high-density lipoprotein particle remodelingGO:03437510.9APOE, APOC3, APOA2, APOA1, CETP, LCAT
32low-density lipoprotein particle remodelingGO:03437410.9AGTR1, LIPC, CETP, APOA2, APOB, AGT
33response to hypoxiaGO:00166610.7TGFB1, TH, EDNRA, EDN1, LTA, PDE5A
34positive regulation of angiogenesisGO:04576610.7F3, HMOX1, PTGIS, TBXA2R, NOS3, ADM
35triglyceride metabolic processGO:00664110.7CAT, GPX1, APOE, APOC3, APOA2, CETP
36response to hydrogen peroxideGO:04254210.7ADA, SLC8A1, SOD1, OLR1, CYP11A1, HMOX1
37platelet degranulationGO:00257610.6PF4, EGF, TIMP1, TGFB1, TGFB3, SOD1
38inflammatory responseGO:00695410.6CRP, SPP1, OLR1, CYBA, TBXA2R, TNFRSF4
39blood circulationGO:00801510.5EPO, ADM, ADORA2A, NPY, CXCL12, OLR1
40response to ethanolGO:04547110.5ADIPOQ, SLC2A4, NPPC, SOD1, TH, NOS3
41negative regulation of cell proliferationGO:00828510.5TGFB3, TGFB1, AGT, NOS3, CTH, DPT
42response to lipopolysaccharideGO:03249610.5PDE5A, LTA, EDN1, EDNRA, THBD, ADM
43agingGO:00756810.4EPO, P2RY2, VCAM1, VDR, JUN, IL15
44positive regulation of cell proliferationGO:00828410.2EDN2, EDN1, CTF1, TBX3, DRD3, EDNRA
45positive regulation of mitosisGO:04584010.2EGF, EDN1, DRD3, TNF, IGF1, IL1B
46platelet activationGO:03016810.1CD40LG, SAA1, CLU, VEGFA, SERPINE1, SERPINF2
47cellular response to lipopolysaccharideGO:07122210.1NOS2, CYP17A1, CYP11A1, TNFSF4, ICAM1, CCR5
48response to mechanical stimulusGO:00961210.0CXCL12, NOS3, PTGER4, TNF, F3, CCL2
49negative regulation of apoptotic processGO:0430669.6CAT, TNF, PF4, EDNRA, TIMP1, CXCL12
50anti-apoptosisGO:0069169.3HMOX1, TNF, TBX3, DDAH2, CTH, NR3C1

Molecular functions related to essential hypertension according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.8POU2F1, THBD, TH, TIPRL, TIMP1, AGTR2
2protein heterodimerization activityGO:04698211.4ADORA1, ADORA2A, TGFB3, TGFB1, ADD1, ADD2
3protein homodimerization activityGO:04280311.4PON1, SOD1, TGFB1, SHBG, NOS2, CRP
4drug bindingGO:00814411.3ADRB1, ADRB2, ACE, PPARG, CYP2C9, CYP2D6
5hormone activityGO:00517911.2GAST, SST, CALCA, IAPP, IGF1, INS
6receptor bindingGO:00510211.2LTA, CXCL12, POMC, NPPA, NPPB, NPPC
7iron ion bindingGO:00550611.1CYP4F2, CYP4A22, CYP2J2, CYP2C9, NOS1, NOS2
8calmodulin bindingGO:00551610.9SLC9A1, RGS2, RGS4, ADD1, ADD2, ADD3
9heme bindingGO:02003710.9CYP17A1, CYP19A1, CYP4F2, CYP4A22, CYP2J2, CYP2C9
10electron carrier activityGO:00905510.9CYP11B1, CYP17A1, CYP19A1, CYP4F2, CYP4A22, CYP2J2
11heparin bindingGO:00820110.8ANG, CCL2, PF4, PRELP, SOD3, KNG1
12protease bindingGO:00202010.5F3, HSPA1B, TNF, CST3, IL1R1, INS
13cytokine activityGO:0051259.2TNF, TNFSF4, SPP1, CTF1, LTA, EDN1
14growth factor activityGO:0080838.5PPBP, EGF, AGT, TGFB1, TGFB3, CXCL12

Sources for Essential Hypertension

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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