MCID: ESS002
MIFTS: 64

Essential Hypertension malady

Cardiovascular category

Summaries for Essential Hypertension

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Essential hypertension (also called primary hypertension or idiopathic hypertension) is the form of... more...

MalaCards: Essential Hypertension, also known as hypertension, essential, is related to insulin resistance and hypertension, diastolic. An important gene associated with Essential Hypertension is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are p70S6K Signaling and Asparagine N-linked glycosylation. The compounds sodium and nitric oxide have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Description from OMIM:47 145500

Aliases & Classifications for Essential Hypertension

Sources:
8Disease Ontology, 9diseasecard, 22GTR, 47OMIM, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

essential hypertension 8 45 61
hypertension, essential 9 22 47
unspecified essential hypertension 8
essential hypertension nos 8
idiopathic hypertension 8
primary hypertension 8


External Ids:

Disease Ontology8 DOID:10825
ICD9CM27 401, 401.9
OMIM47 145500
NCIt40 C3478
ICD1025 I10

Related Diseases for Essential Hypertension

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the hypertension family:

benign essential hypertension malignant essential hypertension
essential hypertension malignant hypertension
familial hypertension hypertension, essential 3
hypertension, essential 7 hypertension, essential 6
hypertension, essential 4 hypertension, essential 2
hypertension, essential 1 hypertension, essential 8
hypertension, essential 5

Diseases related to Essential Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.3HSD11B2, ACE, ADD1, AGT, AGTR1, GNB3
2hypertension, diastolic30.9REN, ACE
3atherosclerosis30.8AGTR1, ACE, PTGIS, GNB3, ADD1, AGT
4coronary heart disease30.6GNB3, NPPB, ACE, AGTR1, ADD1, AGT
5coronary artery disease,30.5AGT, NPPB, AGTR1, ACE, ECE1, GNB3
6renovascular hypertension30.5AGTR1, NPPA, ACE, REN, ADM
7diabetic nephropathy30.4HSD11B2, AGTR1, ACE, ADM, AGT, NPPA
8adenoma30.3ECE1, GNB3, CYP11B2, REN, HSD11B2, PTGIS
9conn's syndrome30.3REN, CYP11B2, NPPA
10stroke, ischemic30.3PTGIS
11arteriosclerosis30.3ADM
12type 1 diabetes30.2ACE, NPPA, AGTR1, AGT, HSD11B2
13hypertensive heart disease30.2NPPA, ACE, AGTR1, NPPB
14hypercholesterolemia30.2AGTR1, AGT, ACE, GNB3
15hypokalemia30.2ACE, HSD11B2, CYP11B2, REN
16vascular disease30.2ACE, AGT, AGTR1, PTGIS
17low renin hypertension30.2REN, CYP11B2, HSD11B2
18nephrosclerosis30.2AGTR1, ACE, ADM
19adrenal adenoma30.2ADM, AGTR1, REN
20liddle syndrome29.9WNK4, NEDD4L
21acromegaly29.9HSD11B2
22acute myocardial infarction29.8AGTR1, AGT, ADM, NPPA, ACE, NPPB
23benign essential hypertension10.8
24hypertension, essential 110.6
25malignant essential hypertension10.6
26hypertension, essential 310.5
27eclampsia10.4
28nephropathy-hypertension10.4
29hypertension, essential, salt-sensitive10.4
30hypertension, essential 210.4
31hypertension, essential 510.4
32n syndrome10.3
33kallikrein hypertension10.3
34hypertension, essential 410.3
35hypertension, essential 810.3
36hyperuricemia10.3
37fatty liver disease10.3
38cytomegalovirus infection10.3
39familial hypertension10.2
40hypertension, insulin resistance-related10.2
41gout10.1
42arteriolosclerosis10.1
43mild pre-eclampsia10.1
44bod syndrome10.1
45carotid intimal medial thickness10.1
46hypertension10.0ACE, AGTR1, AGT, ECE1, CYP11B2, REN
47myocardial infarction10.0ADD1, ADM, PTGIS, ACE, REN, AGT
48cadasil10.0NPPB, GNB3, NPPA, AGTR1, ADD1, ADM
49chronic kidney failure10.0GNB3, NPPB, NPPA, AGTR1, AGT, CYP11B2
50proteinuria10.0ADM, ADD1, ACE, REN, CYP11B2, AGT

Graphical network of the top 20 diseases related to Essential Hypertension:



Diseases related to essential hypertension

Clinical Features for Essential Hypertension

Sources:
47OMIM
See all sources

Clinical features from OMIM:

145500

Clinical synopsis from OMIM:

145500

Drugs & Therapeutics for Essential Hypertension

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Essential Hypertension

Drug clinical trials:

Search ClinicalTrials for Essential Hypertension

Search NIH Clinical Center for Essential Hypertension

Search CenterWatch for Essential Hypertension

Genetic Tests for Essential Hypertension

Sources:
22GTR
See all sources

Genetic tests related to Essential Hypertension:

id Genetic test Affiliating Genes
1 Essential Hypertension22

Anatomical Context for Essential Hypertension

Animal Models for Essential Hypertension or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Essential Hypertension:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.4ACE, PNMT, WNK4, REN, CYP11B2, ECE1
2MP:000538512.4ADM, KLKB1, HSD11B2, NPPB, NPPA, NEDD4L
3MP:001076811.8HSD11B2, NEDD4L, ADM, ACE, GNB3, REN
4MP:000536711.7PTGIS, ACE, WNK4, REN, CYP11B2, AGT
5MP:000536911.3HSD11B2, ADM, REN, CYP11B2, ECE1, AGT

Publications for Essential Hypertension

Sources:
51PubMed
See all sources

Articles related to Essential Hypertension:

(show top 50)    (show all 1911)
idTitleAuthorsYear
1
Sir William Osler and the nature of essential hypertension. (23698005)
2014
2
The Relationship Between Angiotensinogen Gene Polymorphisms and Essential Hypertension in a Northern Han Chinese Population. (23716723)
2013
3
Association of paraoxonase polymorphisms with carotid artery atherosclerosis in essential hypertension patients. (24301778)
2013
4
Endothelial nitric oxide synthase, cyclooxygenase-2, and essential hypertension: is there an interaction? (23918748)
2013
5
Comparative effects of nebivolol and metoprolol on red cell distribution width and neutrophil/lymphocyte ratio in patients with newly diagnosed essential hypertension. (23921307)
2013
6
Gender difference in association of NEDD4L gene variants among southern Han Chinese with essential hypertension - a population-based case-control study. (24047422)
2013
7
Sex-specific effects of NLRP6/AVR and ADM loci on susceptibility to essential hypertension in a Sardinian population. (24147025)
2013
8
The role of matrix metalloproteinases in essential hypertension. (22519445)
2012
9
The efficacy and safety of cilnidipine on mild to moderate essential hypertension: a systematic review and meta-analysis of randomized controlled trials in Chinese patients. (22746347)
2012
10
Relationship between EPHX2 gene polymorphism and essential hypertension in Kazaks and Hans in Xinjiang]. (22336502)
2011
11
G501C polymorphism of the oxidized LDL receptor gene is associated with albuminuria in Chinese essential hypertension patients. (21968806)
2011
12
Comparison of the effects of nebivolol and valsartan on BP reduction and sleep apnoea activity in patients with essential hypertension and OSA. (20560730)
2010
13
Retinol-binding protein-4 in women with untreated essential hypertension. (19556974)
2009
14
Purification and mechanism of action of "cortexin," a novel antihypertensive protein hormone from kidney and its role in essential hypertension in men. (20409952)
2009
15
Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects. (18953403)
2008
16
Clinical value of urinary kidney biomarkers for estimation of renal impairment in elderly Chinese with essential hypertension. (18200578)
2008
17
Cardiovascular reactivity of patients with essential and renal hypertension in an emotion-triggering interview. (17348427)
2007
18
Angiotensinogen M235T gene variants and its association with essential hypertension and plasma renin activity in Malaysian subjects: a case control study. (15811183)
2005
19
Ramipril/felodipine extended-release fixed-dose combination: a review of its use in the management of essential hypertension. (16114982)
2005
20
Benefit assessment of non-drug treatment strategies in patients with essential hypertension: stress-coping interventions: Executive summary of rapid report A05-21F, Version 1.0 (23136677)
2005
21
Lack of association of CCR gene polymorphisms and left ventricular hypertrophy in essential hypertension. (16196460)
2005
22
Plasminogen activator inhibitor-1 (PAI-1) 4G/5G and angiotensin converting enzyme (ACE) I/D gene polymorphisms and fibrinolytic activity in patients with essential hypertension and dyslipidemia]. (16130596)
2005
23
Molecular variants of the sodium/hydrogen exchanger type 3 gene and essential hypertension. (15201541)
2004
24
Lipocalin-type prostaglandin D synthase in essential hypertension. (11882588)
2002
25
Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension. (11918753)
2002
26
Lack of association between T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and essential hypertension. (11131266)
2000
27
Effects of lisinopril and nitrendipine on urinary albumin excretion and renal function in patients with mild to moderate essential hypertension. (11131273)
2000
28
Quinaprilat-induced vasodilatation in forearm vasculature of patients with essential hypertension: comparison with enalaprilat. (11300367)
2000
29
Left ventricular geometry and function in patients with essential hypertension and microalbuminuria. (10419073)
1999
30
Role of endothelin in the increased vascular tone of patients with essential hypertension. (10024340)
1999
31
Accelerated cholesteryl ester transfer in patients with essential hypertension and the effect of ramipril treatment. (9733228)
1998
32
Effects of lacidipine on serum oxygen free radicals and fasting levels of insulin in patients with essential hypertension]. (9868030)
1997
33
Gender differences in the relationships between plasma plasminogen activator inhibitor-1 activity and factors linked to the insulin resistance syndrome in essential hypertension. (9102176)
1997
34
The human angiotensinase C gene (HUMPCP) maps to 11q14 within 700 kb of D11S901: a candidate gene for essential hypertension. (9325062)
1997
35
Attenuation of contractile responses to sympathetic co-transmitters in veins from subjects with essential hypertension. (9174653)
1997
36
Essential hypertension and 5' upstream core promoter region of human angiotensinogen gene. (9403548)
1997
37
Microalbuminuria: a marker of cardiovascular risk and organ damage in essential hypertension. (9407448)
1997
38
Left ventricular diastolic function during adrenergic stress in essential hypertension: acute and chronic effects of ACE inhibition. (8877075)
1996
39
Microalbuminuria in essential hypertension and diabetes mellitus. (8934384)
1996
40
Hormones regulating volume and electrolytes of sweat in patients with essential hypertension. Effect of thermal dehydration and treatment with captopril]. (8230993)
1993
41
Chronic inhibition of endopeptidase 24.11 in essential hypertension: evidence for enhanced atrial natriuretic peptide and angiotensin II. (8390508)
1993
42
A preliminary study of insulin resistance in essential hypertension, simple obesity and acromegaly]. (8200305)
1993
43
The effect of long-term prazosin treatment on plasma follitropin (FSH), lutropin (LH), prolactin, estradiol and testosterone concentration in male patients with essential hypertension]. (8502593)
1993
44
Effect of saline infusion on urinary calcium excretion in essential hypertension. (1826996)
1991
45
Effects of chlorthalidone and metoprolol alone or in combination (logroton) on blood pressure, lipids, lipoproteins and circulating plasma ANF levels in essential hypertension. (1839902)
1991
46
Characterization of the calpastatin defect in erythrocytes from patients with essential hypertension. (2849943)
1988
47
Dopamine reduces aldosterone and 18-hydroxycorticosterone response to angiotensin II in patients with essential low-renin hypertension and idiopathic hyperaldosteronism. (3882312)
1985
48
Experiences with Chlortalidone treatment in benign essential hypertension cases. (6546265)
1984
49
Successful twin pregnancy after treatment of malignant essential hypertension. (13572832)
1958
50
Longevity in benign essential hypertension. (14945948)
1952

Genetic Variations for Essential Hypertension

Expression for genes affiliated with Essential Hypertension

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Essential Hypertension

Search GEO for disease gene expression data for Essential Hypertension.

Pathways for genes affiliated with Essential Hypertension

Sources:
52QIAGEN, 54Reactome, 50PharmGKB, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Essential Hypertension

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Essential Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1sodium45 2413.6KLKB1, HSD11B2, GNB3, NPPB, ADD1, ADM
2nitric oxide45 11 2414.5ECE1, AGT, NPPB, CYP11B2, PNMT, AGTR1
3potassium45 11 2414.4ADD1, ACE, WNK4, REN, CYP11B2, AGT
4glucose4512.3NPPB, AGT, HSD11B2, ECE1, GNB3, AGTR1
5cholesterol45 29 11 2415.2HSD11B2, ACE, CYP11B2, GNB3, AGTR1, AGT
6hydrochlorothiazide45 50 29 11 2416.0AGTR1, NEDD4L, GNB3, HSD11B2, AGT, CYP11B2
7prostacyclin4512.0NPPB, NPPA, AGTR1, AGT, REN, ACE
8ang ii4511.9NPPB, NPPA, AGTR1, CYP11B2, ACE, ADM
9nitroglycerin45 1112.9NPPA, ADM, PTGIS, ACE, REN, AGTR1
10spironolactone50 45 60 29 1115.9ADD1, ACE, REN, CYP11B2, AGTR1, NPPA
11losartan45 50 29 1114.9AGT, REN, AGTR1, NPPA, NPPB, CYP11B2
12epinephrine45 11 2413.8ADM, PNMT, AGTR1, GNB3, NPPB, NPPA
13furosemide45 50 60 29 11 2416.7HSD11B2, ADD1, NPPB, NPPA, AGTR1, REN
14prostaglandin4511.6ADM, AGT, HSD11B2, NPPA, AGTR1, REN
15lisinopril45 11 2413.6ACE, AGT, NPPA, REN, NPPB, AGTR1
16forskolin45 50 1113.6CYP11B2, ADM, HSD11B2, REN, NPPB, NPPA
17atenolol45 29 50 11 2415.6NPPB, ACE, REN, CYP11B2, AGT, AGTR1
18thiazide4511.6ADD1, ACE, WNK4, REN, GNB3, AGTR1
19acth4511.6ADM, REN, HSD11B2, CYP11B2, AGT, AGTR1
20perindopril45 50 1113.6NPPA, AGT, REN, ACE, NPPB, AGTR1
21enalapril45 50 1113.6ACE, AGT, AGTR1, NPPA, NPPB, REN
22amlodipine45 50 11 2414.6ACE, REN, NPPA, AGT, AGTR1, NPPB
23carvedilol45 50 29 1114.6NPPB, ACE, REN, AGTR1, NPPA, ADM
24norepinephrine45 11 2413.5PNMT, CYP11B2, GNB3, KLKB1, ADM
25benazepril45 1112.5ACE, AGT, REN, AGTR1, NPPA
26trandolapril45 1112.5NPPB, AGTR1, REN, NPPA, ACE
27fosinopril45 1112.5NPPB, NPPA, AGTR1, REN, ACE
28haloperidol45 29 2 50 1115.5NPPB, NPPA, AGTR1, REN, AGT, CYP11B2
29enalaprilat4511.5REN, NPPA, NPPB, AGT, ACE
30ramipril45 1112.4NPPA, ACE, REN, AGTR1, NPPB
31valsartan45 60 29 1114.4AGT, NPPB, AGTR1, REN, ACE
32telmisartan45 29 1113.4AGTR1, AGT, REN, ACE, NPPB
33irbesartan45 29 50 1114.4AGT, CYP11B2, REN, ACE, AGTR1
34candesartan45 29 1113.4AGT, NPPB, REN, ACE, AGTR1
35phosphoramidon45 1112.4NPPA, ACE, NPPB, ADM, ECE1
36catecholamine4511.4NPPB, AGTR1, NPPA, REN, PNMT, ADM
37alacepril4511.3NPPB, NPPA, REN, ACE
38aliskiren45 1112.3AGTR1, AGT, REN, ACE
39captopril45 29 50 60 1115.3ADM, REN, ECE1
40saralasin4511.3AGT, REN, ACE, AGTR1
41eprosartan45 29 1113.2AGT, REN, ACE, AGTR1
42nifedipine45 50 29 1114.2CYP11B2, REN, ACE, NPPA, AGTR1, AGT
43cilazapril45 1112.2REN, AGTR1, NPPA, ACE
44digoxin45 50 60 11 2415.2NPPB, NPPA, REN, ACE, AGTR1
45omapatrilat4511.2ADM, ACE, REN, NPPA
46bisoprolol45 50 1113.2ACE, REN, NPPA, NPPB
47moxonidine4511.0NPPB, REN, ACE, NPPA
48olmesartan45 29 1113.0AGTR1, AGT, REN, ACE
49eplerenone45 60 29 1113.9AGTR1, CYP11B2, REN, ACE
50quinapril45 1111.7ACE, NPPA, REN, AGTR1

GO Terms for genes affiliated with Essential Hypertension

Sources:
16Gene Ontology
See all sources

Cellular components related to Essential Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3NPPB, NPPA, AGT, REN, ACE, ADM
2extracellular spaceGO:00561511.1ADM, KLKB1, NPPB, NPPA, AGT, REN

Biological processes related to Essential Hypertension according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821711.6ACSM3, GNB3, NPPB, NPPA, REN, ACE
2proteolysisGO:00650811.4KLKB1, PRCP, ECE1, REN, ACE
3regulation of vasoconstrictionGO:01922911.3ACE, ECE1, AGT, AGTR1
4cellular protein metabolic processGO:04426711.3AGT, REN, ACE, GOSR2, ADD1
5kidney developmentGO:00182211.3AGTR1, AGT, REN, ACE
6renin-angiotensin regulation of aldosterone productionGO:00201811.2AGTR1, AGT, REN
7regulation of vasodilationGO:04231211.2ACE, AGTR1, NPPB
8angiotensin maturationGO:00200311.2ACE, REN, AGT
9response to insulin stimulusGO:03286811.1HSD11B2, NPPA, ADM
10positive regulation of NAD(P)H oxidase activityGO:03386411.1AGTR1, AGT
11regulation of renal output by angiotensinGO:00201911.1AGT, ACE
12regulation of blood volume by renal aldosteroneGO:00201711.1HSD11B2, CYP11B2
13female pregnancyGO:00756511.1HSD11B2, NPPA, ADM
14hormone catabolic processGO:04244711.1ECE1, ACE
15regulation of blood vessel size by renin-angiotensinGO:00203411.1AGTR1, AGT
16cellular sodium ion homeostasisGO:00688311.0AGT, NEDD4L
17regulation of renal sodium excretionGO:03581311.0AGT, AGTR1
18regulation of systemic arterial blood pressure by renin-angiotensinGO:00308111.0ACE, AGTR1
19positive regulation of cholesterol esterificationGO:01087311.0AGT, AGTR1
20positive regulation of angiogenesisGO:04576611.0PTGIS, ADM, ADD1
21cGMP biosynthetic processGO:00618211.0NPPA, NPPB
22low-density lipoprotein particle remodelingGO:03437410.9AGTR1, AGT
23receptor guanylyl cyclase signaling pathwayGO:00716810.9NPPB, NPPA
24positive regulation of cellular protein metabolic processGO:03227010.8AGT, AGTR1
25positive regulation of endocytosisGO:04580710.8NEDD4L, ADD1
26response to salt stressGO:00965110.7AGT, NEDD4L
27positive regulation of macrophage derived foam cell differentiationGO:01074410.7AGT, AGTR1
28positive regulation of renal sodium excretionGO:03581510.6AGT, NPPB
29regulation of blood vessel sizeGO:05088010.4NPPA, NPPB

Molecular functions related to Essential Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517911.0ADM, AGT, NPPA, NPPB
2receptor bindingGO:00510211.0ADM, REN, NPPA, NPPB
3bradykinin receptor bindingGO:03171110.6AGTR1, ACE
4acetyltransferase activator activityGO:01069810.4AGTR1, AGT

Products for genes affiliated with Essential Hypertension

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Essential Hypertension

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet