MCID: ESS002
MIFTS: 71

Essential Hypertension malady

Cardiovascular diseases category

Summaries for Essential Hypertension

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Essential hypertension (also called primary hypertension or idiopathic hypertension) is the form of... more...

MalaCards: Essential Hypertension, also known as hypertension, essential, is related to hypertension and renal hypertension. An important gene associated with Essential Hypertension is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are p70S6K Signaling and Asparagine N-linked glycosylation. The compounds sodium and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, brain and heart, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Description from OMIM:46 145500

Aliases & Classifications for Essential Hypertension

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8Disease Ontology, 44Novoseek, 60UMLS, 9diseasecard, 22GTR, 46OMIM, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

essential hypertension 8 44 60
hypertension, essential 9 22 46
unspecified essential hypertension 8
essential hypertension nos 8
idiopathic hypertension 8
primary hypertension 8


External Ids:

Disease Ontology8 DOID:10825
ICD9CM27 401, 401.9
OMIM46 145500
NCIt39 C3478
ICD1025 I10

Related Diseases for Essential Hypertension

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17GeneCards, 18GeneDecks
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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
essential hypertension Malignant Hypertension
Familial Hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Essential Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.4ACE, AGTR1, AGT, ECE1, CYP11B2, REN
2renal hypertension31.4ADM, ACE, KLKB1, REN
3obesity30.9HSD11B2, AGT, GNB3
4diabetes mellitus30.8ACE, REN, AGT, AGTR1, NPPA, NPPB
5malignant hypertension30.8ACE, REN, ADM
6atherosclerosis30.8AGTR1, ACE, PTGIS, GNB3, ADD1, AGT
7hyperaldosteronism30.7ACE, NPPA, CYP11B2, REN, HSD11B2, AGTR1
8hypertensive heart disease30.7NPPA, ACE, AGTR1, NPPB
9pre-eclampsia30.5CYP11B2, ECE1, ADM, HSD11B2, NPPA, AGTR1
10coronary artery disease30.5AGT, NPPB, AGTR1, ACE, ECE1, GNB3
11renovascular hypertension30.4AGTR1, NPPA, ACE, REN, ADM
12diabetic nephropathy30.4HSD11B2, AGTR1, ACE, ADM, AGT, NPPA
13type 2 diabetes mellitus30.4GNB3, AGTR1, ACE, AGT, ADM
14adenoma30.3ECE1, GNB3, CYP11B2, REN, HSD11B2, PTGIS
15conn's syndrome30.3REN, CYP11B2, NPPA
16glomerulonephritis30.3AGTR1
17stroke, ischemic30.3PTGIS
18arteriosclerosis30.2ADM
19myocardial infarction30.1ADD1, ADM, PTGIS, ACE, REN, AGT
20proteinuria30.1ADM, ADD1, ACE, REN, CYP11B2, AGT
21ischemic heart disease30.1ACE, ADM, AGT, AGTR1, NPPA, NPPB
22ischemia30.1ADM, PTGIS, ECE1, AGT, NPPB
23hypokalemia30.1ACE, HSD11B2, CYP11B2, REN
24vascular disease30.1ACE, AGT, AGTR1, PTGIS
25nephrosclerosis30.1AGTR1, ACE, ADM
26adrenal adenoma30.1ADM, AGTR1, REN
27chronic kidney failure29.9GNB3, NPPB, NPPA, AGTR1, AGT, CYP11B2
28congestive heart failure29.9REN
29mitral valve disease29.9NPPA
30acromegaly29.9HSD11B2
31dementia29.9AGTR1
32acute myocardial infarction29.8AGTR1, AGT, ADM, NPPA, ACE, NPPB
33benign essential hypertension10.8
34malignant essential hypertension10.6
35eclampsia10.3
36cerebritis10.3
37hyperuricemia10.2
38fatty liver disease10.2
39liver disease10.2
40retinitis10.2
41kidney disease10.2
42arteriolosclerosis10.1
43mild pre-eclampsia10.1
44neuronitis10.1
45hypertensive retinopathy10.1
46diffuse glomerulonephritis10.1
47mental depression10.1
48renal vascular disease10.1
49severe pre-eclampsia10.1
50thyroiditis10.1

Graphical network of the top 20 diseases related to Essential Hypertension:



Diseases related to essential hypertension

Clinical Features for Essential Hypertension

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46OMIM
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Clinical features from OMIM:

145500

Clinical synopsis from OMIM:

145500

Drugs & Therapeutics for Essential Hypertension

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Essential Hypertension

Drug clinical trials:

Search ClinicalTrials for Essential Hypertension

Search NIH Clinical Center for Essential Hypertension

Search CenterWatch for Essential Hypertension

Genetic Tests for Essential Hypertension

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22GTR
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Genetic tests related to Essential Hypertension:

id Genetic test Affiliating Genes
1 Essential Hypertension22

Anatomical Context for Essential Hypertension

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32MalaCards
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MalaCards organs/tissues related to Essential Hypertension:

32
Endothelial, Brain, Heart, Kidney, Skeletal muscle, Monocytes, Testes, Liver, Skin, Thyroid, Smooth muscle, Placenta

Animal Models for Essential Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Essential Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.4ACE, PNMT, WNK4, REN, CYP11B2, ECE1
2MP:000538512.4ADM, KLKB1, HSD11B2, NPPB, NPPA, NEDD4L
3MP:001076811.8HSD11B2, NEDD4L, ADM, ACE, GNB3, REN
4MP:000536711.7PTGIS, ACE, WNK4, REN, CYP11B2, AGT
5MP:000536911.3HSD11B2, ADM, REN, CYP11B2, ECE1, AGT

Publications for Essential Hypertension

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50PubMed
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Articles related to Essential Hypertension:

(show top 50)    (show all 1997)
idTitleAuthorsYear
1
Non-alcoholic fatty liver disease is not associated with vitamin D deficiency in essential hypertension. (23584921)
2013
2
Erythrocyte membrane properties in patients with essential hypertension. (23673613)
2013
3
Chinese herbal medicine qi ju di huang wan for the treatment of essential hypertension: a systematic review of randomized controlled trials. (23878593)
2013
4
Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage. (24347798)
2013
5
The mitochondrial tRNA(Met) 4454Ta88>a88C variant may not be associated with essential hypertension in Han Chinese population. (23627313)
2013
6
Night Blood Pressure Responses to Atenolol and Hydrochlorothiazide in Black and White Patients With Essential Hypertension. (23886594)
2013
7
Epoxyeicosatrienoic acids contribute with altered nitric oxide and endothelin-1 pathways to conduit artery endothelial dysfunction in essential hypertension. (22412088)
2012
8
Increased migration of monocytes in essential hypertension is associated with increased transient receptor potential channel canonical type 3 channels. (22438881)
2012
9
High serum levels of CXC (CXCL10) and CC (CCL2) chemokines in untreated essential hypertension. (22697070)
2012
10
Association of the TGF-beta1 gene polymorphisms and blood TGF-beta 1 level with essential hypertension in Kazakh Chinese]. (20677160)
2010
11
Antihypertensive efficacy and safety of olmesartan medoxomil and ramipril in elderly patients with mild to moderate essential hypertension: the ESPORT study. (20829713)
2010
12
Haplotype-based case-control study on human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 gene and essential hypertension. (20010699)
2010
13
Effect of amlodipine and lisinopril on microalbuminuria in patients with essential hypertension: A prospective study. (20535265)
2010
14
Effect of Lacidipine on Blood Pressure and Endothelial Function in Mild-to-Moderate Essential Hypertension Patients With Diabetes in Korea. (21267385)
2010
15
Association of genetic variations of prostasin gene with the essential hypertension in Xinjiang Kazakhs]. (20078940)
2009
16
Association of interleukin-6, interleukin-12, and interleukin-10 gene polymorphisms with essential hypertension in Tatars from Russia. (18163209)
2008
17
Correlation between angiotensinogen gene polymorphisms and essential hypertension in Chinese population. (17823594)
2008
18
Correlation analysis and identification of G421C in regulatory region of CYP4F2 gene with essential hypertension]. (16733892)
2006
19
Polymorphisms in four candidate genes in young patients with essential hypertension. (16497648)
2006
20
A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE. (16514435)
2006
21
A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril. (15788353)
2005
22
Effects of angiotensin II receptor blockade with valsartan on pro-inflammatory cytokines in patients with essential hypertension. (16306795)
2005
23
Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension. (15361761)
2004
24
Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension. (14981055)
2004
25
Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. (14597641)
2003
26
Meta-analysis on the association of AGT M235T polymorphism and essential hypertension in Chinese population]. (14521795)
2003
27
Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis. (12215468)
2002
28
Increased levels of transforming growth factor-beta1 in essential hypertension. (11939608)
2002
29
Association of the T174M polymorphism of the angiotensinogen gene with essential hypertension in Russians and Tatars from Bashkortostan]. (12173461)
2002
30
Impaired sodium excretion during mental stress in mild essential hypertension. (11244019)
2001
31
Effect of the angiotensin II type 1 receptor blocker candesartan on endothelial function in patients with essential hypertension. (10642349)
2000
32
Effect of vitamin C on forearm blood flow and glucose metabolism in essential hypertension. (11073844)
2000
33
The relationship of polymorphism of angiotensinogen and angiotensin converting enzyme with essential hypertension]. (10653905)
2000
34
Improvement of insulin resistance in essential hypertension by long-acting Ca antagonist benidipine. (10574416)
1999
35
Effects of spironolactone and angiotensin-converting enzyme inhibitor on left ventricular hypertrophy in patients with essential hypertension. (10221346)
1999
36
Microalbuminuria in essential hypertension. (10456269)
1999
37
Accelerated cholesteryl ester transfer in patients with essential hypertension and the effect of ramipril treatment. (9733228)
1998
38
Effects of quinapril hydrochloride in patients with essential hypertension and impaired renal function. (9140710)
1997
39
The human angiotensinase C gene (HUMPCP) maps to 11q14 within 700 kb of D11S901: a candidate gene for essential hypertension. (9325062)
1997
40
Effects of acute and chronic angiotensin converting enzyme inhibition by spirapril on cardiovascular regulation in essential hypertensive patients. Assessment by spectral analysis and haemodynamic measurements. (8824693)
1996
41
Polymorphism of the angiotensin I converting enzyme gene in essential hypertensive patients. (7773201)
1995
42
Exercise-induced secretion of brain natriuretic peptide in essential hypertension and normal subjects. (7584923)
1995
43
Increased levels of the soluble adhesion molecule E-selectin in essential hypertension. (7529277)
1994
44
Impaired insulin clearance in essential hypertension. (7911838)
1994
45
Restriction fragment length polymorphisms of the human renin gene: association study with a family history of essential hypertension. (7903395)
1993
46
The sympathetic nervous system may modulate the metabolic cardiovascular syndrome in essential hypertension. (1283768)
1992
47
Membrane transport of cations in erythrocytes during treatment of essential hypertension with angiotensin-converting enzyme inhibitors]. (1638592)
1992
48
The investigation about age-related changes in vasoactive substances of normal subjects and of patients with essential hypertension]. (1630030)
1992
49
Captopril attenuates reflex adrenergic response in essential hypertension. (1994180)
1991
50
Hormone and enzyme assays in pregnancy. 3. The placental cystine-aminopeptidase and the urinary oestrogens in pregnancies complicated with essential hypertension, mild or severe pre-eclampsia. (4406595)
1974

Genetic Variations for Essential Hypertension

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Expression for genes affiliated with Essential Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Essential Hypertension

Search GEO for disease gene expression data for Essential Hypertension.

Pathways for genes affiliated with Essential Hypertension

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Sources:
51QIAGEN, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Essential Hypertension

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Essential Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1sodium44 2413.6KLKB1, HSD11B2, GNB3, NPPB, ADD1, ADM
2nitric oxide44 11 2414.5ECE1, AGT, NPPB, CYP11B2, PNMT, AGTR1
3potassium44 11 2414.4ADD1, ACE, WNK4, REN, CYP11B2, AGT
4glucose4412.3NPPB, AGT, HSD11B2, ECE1, GNB3, AGTR1
5cholesterol44 28 11 2415.2HSD11B2, ACE, CYP11B2, GNB3, AGTR1, AGT
6hydrochlorothiazide44 49 28 11 2416.0AGTR1, NEDD4L, GNB3, HSD11B2, AGT, CYP11B2
7prostacyclin4412.0NPPB, NPPA, AGTR1, AGT, REN, ACE
8ang ii4411.9NPPB, NPPA, AGTR1, CYP11B2, ACE, ADM
9nitroglycerin44 1112.9NPPA, ADM, PTGIS, ACE, REN, AGTR1
10spironolactone49 44 59 28 1115.9ADD1, ACE, REN, CYP11B2, AGTR1, NPPA
11losartan44 49 28 1114.9AGT, REN, AGTR1, NPPA, NPPB, CYP11B2
12epinephrine44 11 2413.8ADM, PNMT, AGTR1, GNB3, NPPB, NPPA
13furosemide44 49 59 28 11 2416.7HSD11B2, ADD1, NPPB, NPPA, AGTR1, REN
14prostaglandin4411.6ADM, AGT, HSD11B2, NPPA, AGTR1, REN
15lisinopril44 11 2413.6ACE, AGT, NPPA, REN, NPPB, AGTR1
16forskolin44 49 1113.6CYP11B2, ADM, HSD11B2, REN, NPPB, NPPA
17atenolol44 28 49 11 2415.6NPPB, ACE, REN, CYP11B2, AGT, AGTR1
18thiazide4411.6ADD1, ACE, WNK4, REN, GNB3, AGTR1
19acth4411.6ADM, REN, HSD11B2, CYP11B2, AGT, AGTR1
20perindopril44 49 1113.6NPPA, AGT, REN, ACE, NPPB, AGTR1
21enalapril44 49 1113.6ACE, AGT, AGTR1, NPPA, NPPB, REN
22amlodipine44 49 11 2414.6ACE, REN, NPPA, AGT, AGTR1, NPPB
23carvedilol44 49 28 1114.6NPPB, ACE, REN, AGTR1, NPPA, ADM
24norepinephrine44 11 2413.5PNMT, CYP11B2, GNB3, KLKB1, ADM
25benazepril44 1112.5ACE, AGT, REN, AGTR1, NPPA
26trandolapril44 1112.5NPPB, AGTR1, REN, NPPA, ACE
27fosinopril44 1112.5NPPB, NPPA, AGTR1, REN, ACE
28haloperidol44 28 2 49 1115.5NPPB, NPPA, AGTR1, REN, AGT, CYP11B2
29enalaprilat4411.5REN, NPPA, NPPB, AGT, ACE
30ramipril44 1112.4NPPA, ACE, REN, AGTR1, NPPB
31valsartan44 59 28 1114.4AGT, NPPB, AGTR1, REN, ACE
32telmisartan44 28 1113.4AGTR1, AGT, REN, ACE, NPPB
33irbesartan44 28 49 1114.4AGT, CYP11B2, REN, ACE, AGTR1
34candesartan44 28 1113.4AGT, NPPB, REN, ACE, AGTR1
35phosphoramidon44 1112.4NPPA, ACE, NPPB, ADM, ECE1
36catecholamine4411.4NPPB, AGTR1, NPPA, REN, PNMT, ADM
37alacepril4411.3NPPB, NPPA, REN, ACE
38aliskiren44 1112.3AGTR1, AGT, REN, ACE
39captopril44 28 49 59 1115.3ADM, REN, ECE1
40saralasin4411.3AGT, REN, ACE, AGTR1
41eprosartan44 28 1113.2AGT, REN, ACE, AGTR1
42nifedipine44 49 28 1114.2CYP11B2, REN, ACE, NPPA, AGTR1, AGT
43cilazapril44 1112.2REN, AGTR1, NPPA, ACE
44digoxin44 49 59 11 2415.2NPPB, NPPA, REN, ACE, AGTR1
45omapatrilat4411.2ADM, ACE, REN, NPPA
46bisoprolol44 49 1113.2ACE, REN, NPPA, NPPB
47moxonidine4411.0NPPB, REN, ACE, NPPA
48olmesartan44 28 1113.0AGTR1, AGT, REN, ACE
49eplerenone44 59 28 1113.9AGTR1, CYP11B2, REN, ACE
50quinapril44 1111.7ACE, NPPA, REN, AGTR1

GO Terms for genes affiliated with Essential Hypertension

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16Gene Ontology
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Cellular components related to Essential Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3KLKB1, NPPB, NPPA, AGT, REN, ACE
2extracellular spaceGO:00561511.1KLKB1, NPPB, NPPA, AGT, REN, ACE

Biological processes related to Essential Hypertension according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821711.6ACSM3, GNB3, NPPB, NPPA, REN, ACE
2proteolysisGO:00650811.4KLKB1, PRCP, ECE1, REN, ACE
3regulation of vasoconstrictionGO:01922911.3ACE, ECE1, AGT, AGTR1
4cellular protein metabolic processGO:04426711.3AGT, REN, ACE, GOSR2, ADD1
5kidney developmentGO:00182211.3AGTR1, AGT, REN, ACE
6renin-angiotensin regulation of aldosterone productionGO:00201811.2AGTR1, AGT, REN
7regulation of vasodilationGO:04231211.2ACE, AGTR1, NPPB
8angiotensin maturationGO:00200311.2ACE, REN, AGT
9response to insulin stimulusGO:03286811.1HSD11B2, NPPA, ADM
10positive regulation of NAD(P)H oxidase activityGO:03386411.1AGTR1, AGT
11regulation of renal output by angiotensinGO:00201911.1AGT, ACE
12regulation of blood volume by renal aldosteroneGO:00201711.1HSD11B2, CYP11B2
13female pregnancyGO:00756511.1HSD11B2, NPPA, ADM
14hormone catabolic processGO:04244711.1ECE1, ACE
15regulation of blood vessel size by renin-angiotensinGO:00203411.1AGTR1, AGT
16cellular sodium ion homeostasisGO:00688311.0AGT, NEDD4L
17regulation of renal sodium excretionGO:03581311.0AGT, AGTR1
18regulation of systemic arterial blood pressure by renin-angiotensinGO:00308111.0ACE, AGTR1
19positive regulation of cholesterol esterificationGO:01087311.0AGT, AGTR1
20positive regulation of angiogenesisGO:04576611.0PTGIS, ADM, ADD1
21cGMP biosynthetic processGO:00618211.0NPPA, NPPB
22low-density lipoprotein particle remodelingGO:03437410.9AGTR1, AGT
23receptor guanylyl cyclase signaling pathwayGO:00716810.9NPPB, NPPA
24positive regulation of cellular protein metabolic processGO:03227010.8AGT, AGTR1
25positive regulation of endocytosisGO:04580710.8NEDD4L, ADD1
26response to salt stressGO:00965110.7AGT, NEDD4L
27positive regulation of macrophage derived foam cell differentiationGO:01074410.7AGT, AGTR1
28positive regulation of renal sodium excretionGO:03581510.6AGT, NPPB
29regulation of blood vessel sizeGO:05088010.4NPPA, NPPB

Molecular functions related to Essential Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517911.0ADM, AGT, NPPA, NPPB
2receptor bindingGO:00510211.0ADM, REN, NPPA, NPPB
3bradykinin receptor bindingGO:03171110.6AGTR1, ACE
4acetyltransferase activator activityGO:01069810.4AGTR1, AGT

Products for genes affiliated with Essential Hypertension

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Essential Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet