MCID: ESS002
MIFTS: 71

Essential Hypertension malady

Cardiovascular diseases category

Summaries for Essential Hypertension

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Essential hypertension (also called primary hypertension or idiopathic hypertension) is the form of... more...

MalaCards: Essential Hypertension, also known as hypertension, essential, is related to hypertension and renal hypertension. An important gene associated with Essential Hypertension is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are p70S6K Signaling and Asparagine N-linked glycosylation. The compounds sodium and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include endothelial, brain and heart, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Description from OMIM:46 145500

Aliases & Classifications for Essential Hypertension

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8Disease Ontology, 44Novoseek, 60UMLS, 9diseasecard, 22GTR, 46OMIM, 56SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

essential hypertension 8 44 60
hypertension, essential 9 22 46
unspecified essential hypertension 8
essential hypertension nos 8
idiopathic hypertension 8
primary hypertension 8


External Ids:

Disease Ontology8 DOID:10825
ICD9CM27 401, 401.9
OMIM46 145500
NCIt39 C3478
ICD1025 I10

Related Diseases for Essential Hypertension

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17GeneCards, 18GeneDecks
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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
essential hypertension Malignant Hypertension
Familial Hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Essential Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.4ACE, AGTR1, AGT, ECE1, CYP11B2, REN
2renal hypertension31.4ADM, ACE, KLKB1, REN
3obesity30.9HSD11B2, AGT, GNB3
4diabetes mellitus30.8ACE, REN, AGT, AGTR1, NPPA, NPPB
5malignant hypertension30.8ACE, REN, ADM
6atherosclerosis30.8AGTR1, ACE, PTGIS, GNB3, ADD1, AGT
7hyperaldosteronism30.7ACE, NPPA, CYP11B2, REN, HSD11B2, AGTR1
8hypertensive heart disease30.7NPPA, ACE, AGTR1, NPPB
9pre-eclampsia30.5CYP11B2, ECE1, ADM, HSD11B2, NPPA, AGTR1
10coronary artery disease30.5AGT, NPPB, AGTR1, ACE, ECE1, GNB3
11renovascular hypertension30.4AGTR1, NPPA, ACE, REN, ADM
12diabetic nephropathy30.4HSD11B2, AGTR1, ACE, ADM, AGT, NPPA
13type 2 diabetes mellitus30.4GNB3, AGTR1, ACE, AGT, ADM
14adenoma30.3ECE1, GNB3, CYP11B2, REN, HSD11B2, PTGIS
15conn's syndrome30.3REN, CYP11B2, NPPA
16glomerulonephritis30.3AGTR1
17stroke, ischemic30.3PTGIS
18arteriosclerosis30.2ADM
19myocardial infarction30.1ADD1, ADM, PTGIS, ACE, REN, AGT
20proteinuria30.1ADM, ADD1, ACE, REN, CYP11B2, AGT
21ischemic heart disease30.1ACE, ADM, AGT, AGTR1, NPPA, NPPB
22ischemia30.1ADM, PTGIS, ECE1, AGT, NPPB
23hypokalemia30.1ACE, HSD11B2, CYP11B2, REN
24vascular disease30.1ACE, AGT, AGTR1, PTGIS
25nephrosclerosis30.1AGTR1, ACE, ADM
26adrenal adenoma30.1ADM, AGTR1, REN
27chronic kidney failure29.9GNB3, NPPB, NPPA, AGTR1, AGT, CYP11B2
28congestive heart failure29.9REN
29mitral valve disease29.9NPPA
30acromegaly29.9HSD11B2
31dementia29.9AGTR1
32acute myocardial infarction29.8AGTR1, AGT, ADM, NPPA, ACE, NPPB
33benign essential hypertension10.8
34malignant essential hypertension10.6
35eclampsia10.3
36cerebritis10.3
37hyperuricemia10.2
38fatty liver disease10.2
39liver disease10.2
40retinitis10.2
41kidney disease10.2
42arteriolosclerosis10.1
43mild pre-eclampsia10.1
44neuronitis10.1
45hypertensive retinopathy10.1
46diffuse glomerulonephritis10.1
47mental depression10.1
48renal vascular disease10.1
49severe pre-eclampsia10.1
50thyroiditis10.1

Graphical network of the top 20 diseases related to Essential Hypertension:



Diseases related to essential hypertension

Clinical Features for Essential Hypertension

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46OMIM
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Clinical features from OMIM:

145500

Clinical synopsis from OMIM:

145500

Drugs & Therapeutics for Essential Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Essential Hypertension

Drug clinical trials:

Search ClinicalTrials for Essential Hypertension

Search NIH Clinical Center for Essential Hypertension

Search CenterWatch for Essential Hypertension

Genetic Tests for Essential Hypertension

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22GTR
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Genetic tests related to Essential Hypertension:

id Genetic test Affiliating Genes
1 Essential Hypertension22

Anatomical Context for Essential Hypertension

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32MalaCards
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MalaCards organs/tissues related to Essential Hypertension:

32
Endothelial, Brain, Heart, Kidney, Skeletal muscle, Monocytes, Testes, Liver, Skin, Smooth muscle, Thyroid, Placenta

Animal Models for Essential Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Essential Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.4AGT, AGTR1, PRCP, NEDD4L, NPPA, HSD11B2
2MP:000538512.4ADM, KLKB1, HSD11B2, NPPB, NPPA, NEDD4L
3MP:001076811.8GNB3, NEDD4L, AGTR1, AGT, ECE1, CYP11B2
4MP:000536711.7HSD11B2, NPPA, NEDD4L, AGTR1, AGT, CYP11B2
5MP:000536911.3HSD11B2, NPPB, NPPA, NEDD4L, AGT, ECE1

Publications for Essential Hypertension

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50PubMed
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Articles related to Essential Hypertension:

(show top 50)    (show all 1997)
idTitleAuthorsYear
1
Insulin resistance in Nigerians with essential hypertension. (24250303)
2013
2
Serene threonine kinase 39 gene single nucleotide A-G polymorphism rs35929607 is weakly associated with essential hypertension in population of Tharparkar, Pakistan. (23894895)
2013
3
Left ventricular mass formulae and prevalence rates of echocardiographic left ventricular hypertrophy in nigerians with essential hypertension. (23814764)
2013
4
The role of matrix metalloproteinases in essential hypertension. (22519445)
2012
5
MMP-2 and sTNF-R1 Variability in Patients with Essential Hypertension: 1-Year Follow-Up Study. (23008783)
2012
6
Application of plasma lipidomics in studying the response of patients with essential hypertension to antihypertensive drug therapy. (22009255)
2011
7
Decreased intralymphocytic magnesium content is associated with diastolic heart dysfunction in patients with essential hypertension. (21242012)
2011
8
Human cytomegalovirus infection is a novel etiology for essential hypertension. (21316863)
2011
9
Percutaneous renal denervation for the treatment of resistant essential hypertension; the first Dutch experience. (21567219)
2011
10
Essential hypertension in adolescents and children: Recent advances in causative mechanisms. (22145141)
2011
11
Should I^ blockers no longer be considered first-line therapy for the treatment of essential hypertension without comorbidities? (21898116)
2011
12
Administration-time-dependent effects of spirapril on ambulatory blood pressure in uncomplicated essential hypertension. (20524801)
2010
13
Essential hypertension: is there a role for inflammatory mechanisms? (19690472)
2009
14
Gender specific association of endothelial nitric oxide synthase gene (Glu298Asp) polymorphism with essential hypertension in a south Indian population. (18582449)
2008
15
Association of adiponectin with procollagen type I carboxyterminal propeptide in non-diabetic essential hypertension. (18671144)
2008
16
Clinical value of urinary kidney biomarkers for estimation of renal impairment in elderly Chinese with essential hypertension. (18200578)
2008
17
Strong association of a renin intronic dimorphism with essential hypertension. (16138564)
2005
18
Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension. (15661075)
2005
19
A polymorphism of kynureninase gene in a hypertensive candidate chromosomal region is associated with essential hypertension]. (16080802)
2005
20
The effect of Ca2+ channel antagonists on plasma concentrations of matrix metalloproteinase-2 and -9 in essential hypertension. (15001203)
2004
21
Free urinary cortisol is elevated in patients with low-renin essential hypertension]. (15543761)
2004
22
Alpha-adducin gene polymorphism is associated with essential hypertension in Chinese: a case-control and family-based study. (14508192)
2003
23
Lipocalin-type prostaglandin D synthase in essential hypertension. (11882588)
2002
24
Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension. (12193054)
2002
25
Essential arterial hypertension and polymorphism of angiotensinogen M235T gene. (12169209)
2002
26
Long term effect of nifedipine GITS and lisinopril on subclinical organ damage in patients with essential hypertension. (11281339)
2001
27
Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population. (11386855)
2001
28
Soluble E-selectin in essential hypertension: a correlate of vascular structural changes. (11281238)
2001
29
Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function. (11693763)
2001
30
Association between albumin:creatinine ratio and 24-hour ambulatory blood pressure in essential hypertension. (11336179)
2001
31
Meta-analysis on the association of ACE/ID polymorphism and essential hypertension in Chinese population]. (11840772)
2001
32
Dopamine D1 receptor gene polymorphism is associated with essential hypertension. (10948075)
2000
33
Role of the angiotensinogen gene for essential hypertension]. (10713906)
2000
34
825T allele of the G-protein beta3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension. (10526907)
1999
35
Vasoconstriction to endogenous endothelin-1 is increased in the peripheral circulation of patients with essential hypertension. (10525485)
1999
36
Association and linkage analyses of glucocorticoid receptor gene markers in essential hypertension. (10601116)
1999
37
Microalbuminuria and transcapillary albumin leakage in essential hypertension. (10489399)
1999
38
Plasma adrenomodullin concentration in patients wtih essential hypertension]. (10101471)
1998
39
Bisoprolol and captopril effects on insulin receptor tyrosine kinase activity in essential hypertension. (9443770)
1997
40
Association analysis of TG repeat polymorphism of the neuronal nitric oxide synthase gene with essential hypertension. (9298742)
1997
41
Corticosteroids in essential hypertension: multiple candidate loci and phenotypic variation. (8713673)
1996
42
Increased thickness of the carotid artery in patients with essential hypertension and microalbuminuria. (8576899)
1995
43
The effect of radon baths at the Khmel'nik health resort on the central hemodynamic indices and calcium-regulating hormones in patients with essential hypertension]. (8630822)
1995
44
Elevated serum insulin levels in patients with essential hypertension and microalbuminuria. (8206563)
1994
45
Plasma glucose and insulin responses to oral glucose loading in nonobese Nigerian subjects with essential hypertension. (8478967)
1993
46
A circulating substance cross-reacting with antiimidazoline antibodies. Detection in serum in relation to essential hypertension. (8349788)
1993
47
Atrial natriuretic factor in essential hypertension: echocardiographic and humoral correlates. (1385563)
1992
48
Effects of atrial natriuretic peptide on glomerular filtration rate in essential hypertension: a radionuclide study. (1826883)
1991
49
Potassium depletion exacerbates essential hypertension. (2058867)
1991
50
Cardiovascular and hormonal effects of clonidine in patients with essential hypertension and renal hypertension. (3913757)
1985

Genetic Variations for Essential Hypertension

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Expression for genes affiliated with Essential Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Essential Hypertension

Search GEO for disease gene expression data for Essential Hypertension.

Pathways for genes affiliated with Essential Hypertension

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Sources:
51QIAGEN, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Essential Hypertension

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Essential Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1sodium44 2413.6KLKB1, HSD11B2, GNB3, NPPB, ADD1, ADM
2nitric oxide44 11 2414.5ECE1, AGT, NPPB, CYP11B2, PNMT, AGTR1
3potassium44 11 2414.4ADD1, ACE, WNK4, REN, CYP11B2, AGT
4glucose4412.3NPPB, AGT, HSD11B2, ECE1, GNB3, AGTR1
5cholesterol44 28 11 2415.2HSD11B2, ACE, CYP11B2, GNB3, AGTR1, AGT
6hydrochlorothiazide44 49 28 11 2416.0AGTR1, NEDD4L, GNB3, HSD11B2, AGT, CYP11B2
7prostacyclin4412.0NPPB, NPPA, AGTR1, AGT, REN, ACE
8ang ii4411.9NPPB, NPPA, AGTR1, CYP11B2, ACE, ADM
9nitroglycerin44 1112.9NPPA, ADM, PTGIS, ACE, REN, AGTR1
10spironolactone49 44 59 28 1115.9ADD1, ACE, REN, CYP11B2, AGTR1, NPPA
11losartan44 49 28 1114.9AGT, REN, AGTR1, NPPA, NPPB, CYP11B2
12epinephrine44 11 2413.8ADM, PNMT, AGTR1, GNB3, NPPB, NPPA
13furosemide44 49 59 28 11 2416.7HSD11B2, ADD1, NPPB, NPPA, AGTR1, REN
14prostaglandin4411.6ADM, AGT, HSD11B2, NPPA, AGTR1, REN
15lisinopril44 11 2413.6ACE, AGT, NPPA, REN, NPPB, AGTR1
16forskolin44 49 1113.6CYP11B2, ADM, HSD11B2, REN, NPPB, NPPA
17atenolol44 28 49 11 2415.6NPPB, ACE, REN, CYP11B2, AGT, AGTR1
18thiazide4411.6ADD1, ACE, WNK4, REN, GNB3, AGTR1
19acth4411.6ADM, REN, HSD11B2, CYP11B2, AGT, AGTR1
20perindopril44 49 1113.6NPPA, AGT, REN, ACE, NPPB, AGTR1
21enalapril44 49 1113.6ACE, AGT, AGTR1, NPPA, NPPB, REN
22amlodipine44 49 11 2414.6ACE, REN, NPPA, AGT, AGTR1, NPPB
23carvedilol44 49 28 1114.6NPPB, ACE, REN, AGTR1, NPPA, ADM
24norepinephrine44 11 2413.5PNMT, CYP11B2, GNB3, KLKB1, ADM
25benazepril44 1112.5ACE, AGT, REN, AGTR1, NPPA
26trandolapril44 1112.5NPPB, AGTR1, REN, NPPA, ACE
27fosinopril44 1112.5NPPB, NPPA, AGTR1, REN, ACE
28haloperidol44 28 2 49 1115.5NPPB, NPPA, AGTR1, REN, AGT, CYP11B2
29enalaprilat4411.5REN, NPPA, NPPB, AGT, ACE
30ramipril44 1112.4NPPA, ACE, REN, AGTR1, NPPB
31valsartan44 59 28 1114.4AGT, NPPB, AGTR1, REN, ACE
32telmisartan44 28 1113.4AGTR1, AGT, REN, ACE, NPPB
33irbesartan44 28 49 1114.4AGT, CYP11B2, REN, ACE, AGTR1
34candesartan44 28 1113.4AGT, NPPB, REN, ACE, AGTR1
35phosphoramidon44 1112.4NPPA, ACE, NPPB, ADM, ECE1
36catecholamine4411.4NPPB, AGTR1, NPPA, REN, PNMT, ADM
37alacepril4411.3NPPB, NPPA, REN, ACE
38aliskiren44 1112.3AGTR1, AGT, REN, ACE
39captopril44 28 49 59 1115.3ADM, REN, ECE1
40saralasin4411.3AGT, REN, ACE, AGTR1
41eprosartan44 28 1113.2AGT, REN, ACE, AGTR1
42nifedipine44 49 28 1114.2CYP11B2, REN, ACE, NPPA, AGTR1, AGT
43cilazapril44 1112.2REN, AGTR1, NPPA, ACE
44digoxin44 49 59 11 2415.2NPPB, NPPA, REN, ACE, AGTR1
45omapatrilat4411.2ADM, ACE, REN, NPPA
46bisoprolol44 49 1113.2ACE, REN, NPPA, NPPB
47moxonidine4411.0NPPB, REN, ACE, NPPA
48olmesartan44 28 1113.0AGTR1, AGT, REN, ACE
49eplerenone44 59 28 1113.9AGTR1, CYP11B2, REN, ACE
50quinapril44 1111.7ACE, NPPA, REN, AGTR1

GO Terms for genes affiliated with Essential Hypertension

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16Gene Ontology
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Cellular components related to Essential Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.3NPPB, NPPA, AGT, REN, ACE, ADM
2extracellular spaceGO:00561511.1ADM, KLKB1, NPPB, NPPA, AGT, REN

Biological processes related to Essential Hypertension according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821711.6ACSM3, GNB3, NPPB, NPPA, REN, ACE
2proteolysisGO:00650811.4KLKB1, PRCP, ECE1, REN, ACE
3regulation of vasoconstrictionGO:01922911.3ACE, ECE1, AGT, AGTR1
4cellular protein metabolic processGO:04426711.3AGT, REN, ACE, GOSR2, ADD1
5kidney developmentGO:00182211.3AGTR1, AGT, REN, ACE
6renin-angiotensin regulation of aldosterone productionGO:00201811.2AGTR1, AGT, REN
7regulation of vasodilationGO:04231211.2ACE, AGTR1, NPPB
8angiotensin maturationGO:00200311.2ACE, REN, AGT
9response to insulin stimulusGO:03286811.1HSD11B2, NPPA, ADM
10positive regulation of NAD(P)H oxidase activityGO:03386411.1AGTR1, AGT
11regulation of renal output by angiotensinGO:00201911.1AGT, ACE
12regulation of blood volume by renal aldosteroneGO:00201711.1HSD11B2, CYP11B2
13female pregnancyGO:00756511.1HSD11B2, NPPA, ADM
14hormone catabolic processGO:04244711.1ECE1, ACE
15regulation of blood vessel size by renin-angiotensinGO:00203411.1AGTR1, AGT
16cellular sodium ion homeostasisGO:00688311.0AGT, NEDD4L
17regulation of renal sodium excretionGO:03581311.0AGT, AGTR1
18regulation of systemic arterial blood pressure by renin-angiotensinGO:00308111.0ACE, AGTR1
19positive regulation of cholesterol esterificationGO:01087311.0AGT, AGTR1
20positive regulation of angiogenesisGO:04576611.0PTGIS, ADM, ADD1
21cGMP biosynthetic processGO:00618211.0NPPA, NPPB
22low-density lipoprotein particle remodelingGO:03437410.9AGTR1, AGT
23receptor guanylyl cyclase signaling pathwayGO:00716810.9NPPB, NPPA
24positive regulation of cellular protein metabolic processGO:03227010.8AGT, AGTR1
25positive regulation of endocytosisGO:04580710.8NEDD4L, ADD1
26response to salt stressGO:00965110.7AGT, NEDD4L
27positive regulation of macrophage derived foam cell differentiationGO:01074410.7AGT, AGTR1
28positive regulation of renal sodium excretionGO:03581510.6AGT, NPPB
29regulation of blood vessel sizeGO:05088010.4NPPA, NPPB

Molecular functions related to Essential Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517911.0ADM, AGT, NPPA, NPPB
2receptor bindingGO:00510211.0ADM, REN, NPPA, NPPB
3bradykinin receptor bindingGO:03171110.6AGTR1, ACE
4acetyltransferase activator activityGO:01069810.4AGTR1, AGT

Products for genes affiliated with Essential Hypertension

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Essential Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet