MCID: ESS002
MIFTS: 73

Essential Hypertension malady

Genetic diseases, Cardiovascular diseases, Blood diseases, Rare diseases categories
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Summaries for Essential Hypertension

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Wikipedia:65 Essential hypertension (also called primary hypertension or idiopathic hypertension) is the form of... more...

MalaCards based summary: Essential Hypertension, also known as hypertension, essential, is related to hypertension and insulin resistance, and has symptoms including An important gene associated with Essential Hypertension is AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)), and among its related pathways are Sympathetic Nerve Pathway (Neuroeffector Junction) and G protein signaling G Protein alpha i signaling cascades. The compounds aliskiren and saralasin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, brain and heart, and related mouse phenotypes are growth/size/body and muscle.

Description from OMIM:46 145500

Aliases & Classifications for Essential Hypertension

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 9diseasecard, 22GTR, 46OMIM, 27ICD9CM, 39NCIt, 57SNOMED-CT, 25ICD10
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Essential Hypertension, Aliases & Descriptions:

Name: Essential Hypertension 8 44 62
Hypertension, Essential 9 22 46
Unspecified Essential Hypertension 8 62
 
Idiopathic Hypertension 8 62
Essential Hypertension Nos 8
Primary Hypertension 8


Classifications:



External Ids:

Disease Ontology8 DOID:10825
ICD9CM27 401, 401.9
NCIt39 C3478
OMIM46 145500
ICD1025 I10

Related Diseases for Essential Hypertension

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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
essential hypertension Malignant Hypertension
Familial Hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Essential Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.0GNB3, PTGIS, NEDD4L, ADRB1, ADD1, ADM
2insulin resistance32.0GNB3, ADD1, UTS2, ACE, AGT, AGTR1
3hyperaldosteronism31.6CYP11B2, REN, ACE, NPPA, AGTR1
4diabetes mellitus31.5GNB3, UTS2, REN, ACE, NPPA, AGT
5low renin hypertension31.2REN, CYP11B2
6conn's syndrome31.2NPPA, REN, CYP11B2
7renovascular hypertension31.2ADM, REN, ACE, NPPA, AGTR1
8type 2 diabetes mellitus31.1GNB3, ADM, UTS2, ACE, AGT, AGTR1
9diabetic nephropathy31.0ADM, UTS2, REN, ACE, NPPA, AGT
10malignant hypertension31.0ADM, REN, ACE
11hypertensive heart disease31.0ACE, NPPA, AGTR1
12hypokalemia31.0CYP11B2, REN, ACE
13nephrosclerosis31.0AGTR1, ACE, ADM
14hypercholesterolemia31.0GNB3, ACE, AGT, AGTR1
15mitral valve disease30.9NPPA
16atherosclerosis30.9ECE1, GNB3, PTGIS, ADD1, UTS2, ACE
17congestive heart failure30.9UTS2, REN
18pre-eclampsia30.8ECE1, CYP11B2, ADM, UTS2, REN, NPPA
19adrenal adenoma30.8REN, ADM, CYP11B2
20renal hypertension30.8ADM, REN, ACE, KLKB1
21proteinuria30.7GNB3, ADD1, ADM, UTS2, REN, ACE
22vascular disease30.7PTGIS, ACE, AGT, AGTR1
23adenoma30.5ECE1, CYP11B2, GNB3, PTGIS, REN
24acute myocardial infarction30.4ADRB1, ADM, UTS2, ACE, NPPA, AGT
25ischemia30.3AGT, ADM, PTGIS, ECE1
26myocardial infarction30.0ADM, UTS2, REN, ACE, NPPA, AGT
27endotheliitis10.9
28benign essential hypertension10.8
29obesity10.7
30fibromuscular dysplasia10.6REN
31blindness10.6
32malignant essential hypertension10.6
33oligohydramnios10.6ACE
34hypoaldosteronism10.6CYP11B2, REN
35hepatorenal syndrome10.6NPPA, REN
36renal tubular dysgenesis10.6REN, AGT, AGTR1
37sick sinus syndrome10.6NPPA
38mitral valve prolapse10.6AGTR1
39liddle syndrome10.5CYP11B2, NEDD4L, REN
40hypertension, diastolic10.5REN, ACE
41pseudohypoaldosteronism type ii10.5REN, WNK4
42glucocorticoid-remediable aldosteronism10.5REN, CYP11B2
43adrenocortical carcinoma10.5CYP11B2
44cor pulmonale10.5AGTR1, NPPA
45renal fibrosis10.5AGTR1, AGT, REN
46idiopathic edema10.5ADM, ACE, NPPA
47polycystic kidney disease, autosomal dominant10.5ADD1, REN, ACE
48gitelman syndrome10.5REN, AGT
49phaeochromocytoma10.5ADM
50pure autonomic failure10.5GNB3, NEDD4L, REN, ACE, NPPA

Graphical network of the top 20 diseases related to Essential Hypertension:



Diseases related to essential hypertension

Symptoms for Essential Hypertension

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Symptoms by clinical synopsis from OMIM:

145500

Clinical features from OMIM:

145500

HPO human phenotypes related to Essential Hypertension:

id Description Frequency HPO Source Accession
1 multifactorial inheritance HP:0001426
2 elevated systolic blood pressure HP:0004421
3 elevated mean arterial pressure HP:0004972
4 elevated diastolic blood pressure HP:0005117

Drugs & Therapeutics for Essential Hypertension

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Drug clinical trials:

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Search NIH Clinical Center for Essential Hypertension

Genetic Tests for Essential Hypertension

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Genetic tests related to Essential Hypertension:

id Genetic test Affiliating Genes
1 Essential Hypertension22

Anatomical Context for Essential Hypertension

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MalaCards organs/tissues related to Essential Hypertension:

32
Endothelial, Brain, Heart, Kidney, Monocytes, Skeletal muscle, Testes, Liver, Skin, Smooth muscle, Thyroid, Neutrophil, Placenta

Animal Models for Essential Hypertension or affiliated genes

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MGI Mouse Phenotypes related to Essential Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053789.8ADRB1, ADD1, PRCP, REN, ACE, AGT
2MP:00053699.6ECE1, CYP11B2, NEDD4L, ADRB1, ADM, REN
3MP:00053679.6CYP11B2, PTGIS, NEDD4L, ADM, REN, WNK4
4MP:00053859.3AGTR1, ECE1, CYP11B2, PNMT, PTGIS, NEDD4L
5MP:00107689.2ECE1, CYP11B2, GNB3, NEDD4L, ADRB1, ADD1
6MP:00053769.1ADD1, ADRB1, NEDD4L, PTGIS, PNMT, CYP11B2

Publications for Essential Hypertension

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Articles related to Essential Hypertension:

(show top 50)    (show all 1923)
idTitleAuthorsYear
1
The effect of melatonin on circadian blood pressure in patients with type 2 diabetes and essential hypertension. (25276149)
2014
2
Effects of music on cardiovascular responses in men with essential hypertension compared with healthy men based on introversion and extraversion. (25320667)
2014
3
Myocardial performance index and aortic distensibility in patients with different left ventricle geometry in newly diagnosed essential hypertension. (23550550)
2013
4
Physical activity opposes the age-related increase in skeletal muscle and plasma endothelin-1 levels and normalizes plasma endothelin-1 levels in individuals with essential hypertension. (23227981)
2013
5
Interaction between Occupational Stress and GR Gene Polymorphisms on Essential Hypertension among Railway Workers. (23892638)
2013
6
Presence of mutation m.14484T>C in a Chinese family with maternally inherited essential hypertension but no expression of LHON. (22749828)
2012
7
Association between human cartilage glycoprotein 39 (YKL-40) and arterial stiffness in essential hypertension. (22642467)
2012
8
Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT). (21906391)
2011
9
Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs. (21482395)
2011
10
Association of the TGF-beta1 gene polymorphisms and blood TGF-beta 1 level with essential hypertension in Kazakh Chinese]. (20677160)
2010
11
A potential regulatory single nucleotide polymorphism in the promoter of the Klotho gene may be associated with essential hypertension in the Chinese Han population. (20005218)
2010
12
Genetic variants of beta(1)-adrenoceptor gene polymorphisms (Ser49Gly and Arg389Gly) and essential hypertension in a south Indian Tamil population. (19673943)
2009
13
Retinol-binding protein-4 in women with untreated essential hypertension. (19556974)
2009
14
Association of genetic variations of prostasin gene with the essential hypertension in Xinjiang Kazakhs]. (20078940)
2009
15
Association of tryptophan hydroxylase gene A218C and serotonin transporter gene polymorphism with essential hypertension in Chinese northern Han population]. (19961731)
2009
16
Independent association of circulating resistin with glomerular filtration rate in the early stages of essential hypertension. (19262583)
2009
17
Comparative transcriptome analysis of human aorta atherosclerotic lesions and peripheral blood leukocytes from essential hypertension patients]. (19772500)
2009
18
The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels. (18068006)
2008
19
Association between prostaglandin E2 receptor gene and essential hypertension. (17644362)
2007
20
Effects of valsartan and indapamide on plasma cytokines in essential hypertension. (17062919)
2006
21
beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. (16815314)
2006
22
Effect of interleukin 8 and ICAM-1 on calcium-dependent outflow of K+ in erythrocytes from subjects with essential hypertension. (14741067)
2004
23
Alpha-adducin Gly460Trp polymorphism and essential hypertension in Korea. (15608390)
2004
24
Tibetan patients with essential hypertension caused by underlying oxidative metabolism dysfunction and depressed nitric oxide synthesis. (12775254)
2003
25
An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension. (12037699)
2002
26
A study of the hereditary susceptibility of HLA-DQA1 to essential hypertension, athrothrombotic brain infarction and lacunar stroke]. (11798899)
2001
27
Dopamine D1 receptor gene polymorphism is associated with essential hypertension. (10948075)
2000
28
Adrenomedullin and membrane fluidity of erythrocytes in mild essential hypertension. (10067789)
1999
29
Improvement of insulin resistance in essential hypertension by long-acting Ca antagonist benidipine. (10574416)
1999
30
Increased plasma proadrenomedullin N-terminal 20 peptide in patients with essential hypertension. (10505213)
1999
31
Candesartan cilexetil. A review of its use in essential hypertension. (9829158)
1998
32
Effect of the vasodilatory beta-blocker, nipradilol, and Ca-antagonist, barnidipine, on insulin sensitivity in patients with essential hypertension. (9764719)
1998
33
Is insulin action a determinant of left ventricular relaxation in uncomplicated essential hypertension? (9222942)
1997
34
Bisoprolol and captopril effects on insulin receptor tyrosine kinase activity in essential hypertension. (9443770)
1997
35
Corticosteroids in essential hypertension: multiple candidate loci and phenotypic variation. (8713673)
1996
36
Urinary excretion rate of endothelin-1 in patients with essential hypertension and salt sensitivity. (8164445)
1994
37
Effects of an oral prostaglandin E1 agonist on blood pressure and its determinants in essential hypertension. (7932515)
1994
38
Insulin-like growth factor I and collagen type III synthesis in patients with essential hypertension and left ventricular hypertrophy. (7807509)
1994
39
Renal effects of atrial natriuretic peptide during dopa-decarboxylase inhibition in patients with essential hypertension. (8359177)
1993
40
Hormones regulating volume and electrolytes of sweat in patients with essential hypertension. Effect of thermal dehydration and treatment with captopril]. (8230993)
1993
41
Effects of an orally active renin inhibitor, Ro 42-5892, in patients with essential hypertension. (8512659)
1993
42
The effect of angiotensin II on platelet intracellular free magnesium and calcium ionic concentrations in essential hypertension. (8390527)
1993
43
Value of oxypurines and uric acid in plasma, renal excretion of oxypurines and uric acid as well as plasma adenosine deaminase and AMP deaminase activity in patients with essential hypertension]. (8327372)
1993
44
Insulin resistance and essential hypertension: pathophysiologic and therapeutic implications. (1593308)
1992
45
Serum insulin, insulin sensitivity, and erythrocyte sodium metabolism in normotensive and essential hypertensive subjects with and without overweight. (2065466)
1991
46
Abnormal tubular handling of sodium and water induced by atrial natriuretic peptide in essential hypertension. (1829753)
1991
47
Increase of circulating levels of insulin and C-peptide: common factors in essential hypertension and overweight]. (2093360)
1990
48
Treatment of benign essential hypertension with frusemide in different doses. (7001489)
1980
49
Successful twin pregnancy after treatment of malignant essential hypertension. (13572832)
1958
50
Cortisone and ACTH in essential hypertension; establishment of renal glycosuria. (14818448)
1951

Variations for Essential Hypertension

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Clinvar genetic disease variations for Essential Hypertension:

6
id Gene Name Type Significance SNP ID Assembly Location
1PTGISPTGIS, IVS9, T-C, +2single nucleotide variantPathogenic

Expression for genes affiliated with Essential Hypertension

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Expression patterns in normal tissues for genes affiliated with Essential Hypertension

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Pathways for genes affiliated with Essential Hypertension

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Pathways related to Essential Hypertension according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ADM, ADRB1
2
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
10.2GNB3, ADRB1, ADD1
310.2WNK4, ADD1, NEDD4L
410.2ADM, ADRB1, GNB3
5
Show member pathways
10.2GNB3, UTS2, AGT, AGTR1
6
Show member pathways
10.1GNB3, REN, ACE, AGT
7
Show member pathways
10.1AGTR1, AGT, ACE, REN, CYP11B2
8
Show member pathways
10.0GNB3, UTS2, REN, ACE, AGT, AGTR1
9
Show member pathways
10.0GOSR2, GNB3, ADD1, REN, ACE, AGT
10
Show member pathways
9.9GNB3, ADRB1, ADM, UTS2, AGT, AGTR1
11
Show member pathways
9.8GNB3, NEDD4L, ADRB1, ADM, UTS2, AGT

Compounds for genes affiliated with Essential Hypertension

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Compounds related to Essential Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 163)
idCompoundScoreTop Affiliating Genes
1aliskiren44 1111.5AGT, ACE, REN, AGTR1
2saralasin4410.5AGT, ACE, REN, AGTR1
3eprosartan44 28 1112.5REN, ACE, AGT, AGTR1
4cilazapril44 1111.5AGTR1, NPPA, REN, ACE
5lisinopril44 50 24 1113.4REN, AGTR1, AGT, NPPA, ACE
6trandolapril44 1111.4REN, ACE, NPPA, AGTR1
7perindopril44 50 1112.4REN, ACE, NPPA, AGT, AGTR1
8olmesartan44 28 1112.4AGTR1, AGT, ACE, REN
9irbesartan44 28 50 1113.4ACE, CYP11B2, REN, AGT, AGTR1
10candesartan44 50 28 1113.4AGTR1, AGT, CYP11B2, REN, ACE
11eplerenone44 61 28 1113.4AGTR1, CYP11B2, REN, ACE
12amlodipine44 50 24 1113.4ACE, AGTR1, AGT, NPPA, REN
13enalapril44 50 1112.4REN, ACE, NPPA, AGT, AGTR1
14fosinopril44 1111.4REN, ACE, NPPA, AGTR1
15bisoprolol44 50 1112.4ACE, REN, NPPA, ADRB1
16omapatrilat4410.4NPPA, ADM, REN, ACE
17enalaprilat4410.4REN, AGT, ACE, NPPA
18thiazide4410.4ACE, WNK4, GNB3, AGTR1, ADD1, REN
19quinapril44 50 1112.4AGTR1, ACE, REN, NPPA
20furosemide44 61 28 50 24 1115.3AGTR1, NPPA, ACE, REN, GNB3, ADD1
21spironolactone44 61 28 50 1114.3CYP11B2, ADD1, REN, ACE, NPPA, AGTR1
22benazepril44 50 1112.3NPPA, AGT, AGTR1, ACE, PRCP, REN
23atenolol44 50 28 24 1114.3ADRB1, GNB3, CYP11B2, AGTR1, AGT, REN
24nitroglycerin44 1111.3GNB3, ACE, REN, ADM, PTGIS, AGTR1
25carvedilol44 50 28 1113.3ADRB1, ADM, REN, NPPA, AGTR1, ACE
26captopril44 61 50 28 1114.3ADM, NPPA, AGT, ACE, ECE1, AGTR1
27phenylephrine44 28 24 1113.3NPPA, AGT, AGTR1, UTS2, ADM, ADRB1
28ang ii4410.3ACE, NPPA, REN, ADM, CYP11B2, AGTR1
29losartan44 50 28 1113.3REN, ACE, ADM, NPPA, AGT, CYP11B2
30hydrochlorothiazide44 28 50 24 1114.3AGTR1, CYP11B2, NEDD4L, AGT, ACE, REN
31metoprolol44 50 28 24 1114.2REN, ADRB1, ACE, NPPA
32nifedipine44 28 50 1113.2REN, AGT, AGTR1, CYP11B2, ACE, NPPA
33catecholamine4410.2NPPA, AGTR1, PNMT, REN, ADM, ADRB1
34clonidine44 50 28 1113.2REN, AGTR1, PNMT, ADRB1, GNB3
35prostacyclin4410.2ACE, ECE1, PTGIS, ADM, REN, NPPA
36kininogen4410.2NPPA, PRCP, REN, KLKB1, ACE
37epinephrine44 24 1112.1ADM, PNMT, GNB3, AGTR1, ADRB1, NPPA
38ramipril44 1111.1AGTR1, NPPA, REN, ACE
39chymostatin4410.0ACE, AGTR1, REN, AGT
40isoproterenol44 1111.0ADM, AGT, AGTR1, NPPA, REN, ADRB1
41prostaglandin4410.0REN, PTGIS, NPPA, AGT, AGTR1, ADM
42cholesterol44 28 24 1112.9ADD1, PTGIS, GNB3, CYP11B2, ADM, REN
43forskolin44 50 1111.8ADRB1, ADM, REN, NPPA, AGT, AGTR1
44potassium44 24 1111.8GNB3, CYP11B2, ADRB1, ADD1, AGTR1, AGT
45glucose449.8GNB3, AGTR1, ADD1, ADRB1, CYP11B2, ADM
46norepinephrine44 24 1111.8AGTR1, AGT, NPPA, KLKB1, ACE, REN
47thiorphan44 28 1111.8ACE, ECE1, ADM, NPPA
48lipid449.8GNB3, ACE, UTS2, ADM, ADD1, ADRB1
49nitric oxide44 24 1111.6ADRB1, GNB3, AGTR1, AGT, NPPA, ECE1
50sodium44 2410.6WNK4, REN, UTS2, ADM, ADD1, ADRB1

GO Terms for genes affiliated with Essential Hypertension

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Cellular components related to Essential Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.8UTS2, REN, ACE, KLKB1, NPPA, AGT
2extracellular spaceGO:0056159.6AGT, PTGIS, ADM, UTS2, REN, ACE
3plasma membraneGO:0058869.3ECE1, GNB3, NEDD4L, ADRB1, ADD1, PRCP

Biological processes related to Essential Hypertension according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.7AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00203410.7AGT, AGTR1
3regulation of renal sodium excretionGO:03581310.7AGTR1, AGT
4regulation of renal output by angiotensinGO:00201910.7ACE, AGT
5hormone catabolic processGO:04244710.7ECE1, ACE
6cellular sodium ion homeostasisGO:00688310.6NEDD4L, AGT
7renin-angiotensin regulation of aldosterone productionGO:00201810.6REN, AGT, AGTR1
8positive regulation of cation channel activityGO:200125910.6NEDD4L, ADRB1
9regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.6ACE, AGTR1
10positive regulation of cholesterol esterificationGO:01087310.6AGTR1, AGT
11angiotensin maturationGO:00200310.6AGT, ACE, REN
12negative regulation of systemic arterial blood pressureGO:00308510.6NEDD4L, NPPA
13low-density lipoprotein particle remodelingGO:03437410.6AGTR1, AGT
14negative regulation of urine volumeGO:03581110.6ADRB1, UTS2
15regulation of vasodilationGO:04231210.6AGTR1, ACE
16positive regulation of cellular protein metabolic processGO:03227010.6AGT, AGTR1
17regulation of vasoconstrictionGO:01922910.6AGTR1, AGT, ACE, ECE1
18response to coldGO:00940910.5AGT, ADM, ADRB1
19kidney developmentGO:00182210.5REN, ACE, AGT, AGTR1
20positive regulation of endocytosisGO:04580710.5ADD1, NEDD4L
21positive regulation of heart rateGO:01046010.4ADM, UTS2
22positive regulation of angiogenesisGO:04576610.4PTGIS, ADD1, ADM, UTS2
23response to salt stressGO:00965110.4NEDD4L, AGT
24positive regulation of macrophage derived foam cell differentiationGO:01074410.3AGTR1, AGT
25cellular protein metabolic processGO:04426710.3GOSR2, ADD1, REN, ACE, AGT
26regulation of blood pressureGO:00821710.3NPPA, GNB3, UTS2, REN, ACE, ACSM3
27positive regulation of cytosolic calcium ion concentrationGO:00720410.3ADM, UTS2, AGTR1
28regulation of calcium ion transportGO:05192410.3AGT, ADRB1
29agingGO:00756810.3AGT, ADM, ADRB1
30blood coagulation, intrinsic pathwayGO:00759710.2KLKB1, PRCP
31response to hypoxiaGO:0016669.8ADM, UTS2, NPPA

Molecular functions related to Essential Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.2AGTR1, ACE
2hormone activityGO:00517910.1AGT, NPPA, UTS2, ADM
3receptor bindingGO:0051029.8ADM, UTS2, REN, NPPA
4protein bindingGO:0055159.5PTGIS, NEDD4L, ADRB1, ADM, PRCP, WNK4

Products for genes affiliated with Essential Hypertension

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Sources for Essential Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet