Essential Tremor malady

NIH Rare Diseases: Essential tremor is a disorder of the nervous system that causes involuntary, rhythmic shaking (tremor), especially in the hands. It involves tremor without any other signs or symptoms, and is distinguished from tremor that results from other disorders or known causes, such as tremors seen with Parkinson disease or head trauma. Essential tremor (sometimes called benign essential tremor) is the most common of the more than 20 types of tremor. Essential tremor is a complex disorder. Several genes are believed to help determine an individual's risk of developing this condition. Environmental factors may also be involved. In mild cases, treatment may not be necessary. In cases where symptoms interfere with daily living, medications may help to relieve symptoms. ³⁰

MalaCards: Essential Tremor, also known as benign essential tremor, is related to parkinson's disease and alcoholism. An important gene associated with Essential Tremor is DRD3 (dopamine receptor D3), and among its related pathways are GABA signaling in brain and Celecoxib Pathway, Pharmacokinetics. The drugs propranolol and propranolol hydrochloride and the compounds clozapine and Halazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are integument and nervous system.

NINDS: Tremor is an unintentional, somewhat rhythmic, muscle movement involving to-and-fro movements (oscillations) of one or more parts of the body. Essential tremor (previously called benign essential tremor) is the most common form of abnormal tremor. (In some people, tremor is a symptom of a neurological disorder or appears as a side effect of certain drugs.) ³¹

Genetics Home Reference: Essential tremor is a disorder of the nervous system that causes involuntary, rhythmic shaking (tremor), especially in the hands. It involves tremor without any other signs or symptoms, and is distinguished from tremor that results from other disorders or known causes, such as tremors seen with Parkinson disease or head trauma.¹⁷

Wikipedia: Essential tremor (ET) is a progressive neurological disorder of which the most recognizable feature is a...⁴⁴ more...

OMIM: 190300

Aliases & Descriptions:

essential tremor 6 30 17 31 8 33 32 43 benign essential tremor 6 30 17 tremor hereditary essential, 1 30 16 hereditary essential tremor 30 17 familial tremor 17 43 benign essential tremor (disorder) 6 tremor, hereditary essential, 1 30

tremor familial essential, 1 30 essential tremor (finding) 6 presenile tremor syndrome 30 familial essential tremor 30 fet1 30 etm1 30

Diseases related to essential tremor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 120)

id	Related Disease	Score	Top Affiliating Genes
1	parkinson's disease	31.3	GCH1, PARK2, ATXN2, FMR1, TPH1, DRD3
2	alcoholism	28.1	ARSA, ALAD, HNMT, TPH1, DRD3, SNCA
3	amyotrophic lateral sclerosis	24.9	PARK2, SCN8A, MTHFR, ATXN2, GSTP1, APOB
4	lateral sclerosis	24.9	PARK2, SCN8A, MTHFR, ATXN2, GSTP1, APOB
5	tremor	24.4	VIM, LINGO2, LINGO1, PARK2, SCN8A, MTHFR
6	parkinson disease 10	13.7	PARK2, SNCA, LRRK2
7	parkinson disease type 3	13.7	PARK2, SNCA, LRRK2
8	tauopathy	13.6	PARK2, SNCA, LRRK2
9	personality disorder	13.5	TPH1, DRD3, SLC6A3
10	dysautonomia	13.5	PARK2, FMR1, SNCA, GBA
11	spinocerebellar ataxia type 3	13.5	PARK2, ATXN2, SNCA, SLC6A3
12	gaze palsy	13.5	ATP13A2, SNCA, GBA
13	drug dependence	13.5	DRD3, SNCA, SLC6A3, ADH1B
14	manic-depressive illness	13.4	TPH1, DRD3, SLC6A3
15	progressive supranuclear palsy	13.4	PARK2, SNCA, LRRK2, SLC6A3, GBA
16	supranuclear palsy	13.4	PARK2, SNCA, LRRK2, SLC6A3, GBA
17	lewy body dementia	13.4	PARK2, CYP2D6, SNCA, LRRK2, SLC6A3
18	dystonia musculorum deformans	13.3	GCH1, ASS1, HS1BP3
19	rem sleep behavior disorder	13.3	SNCA, SLC6A3
20	sepiapterin reductase deficiency	13.2	GCH1, PARK2, TPH1, SLC6A3
21	attention deficit hyperactivity disorder	13.2	FMR1, DRD3, COMT, SLC6A3
22	cognitive disease	13.2	PARK2, DRD3, SNCA, COMT, SLC6A3
23	paralysis	13.1	PARK2, SCN8A, ATXN2, ALAD, DRD3, SNCA
24	olivopontocerebellar atrophy	13.1	ATXN2, FMR1, SNCA
25	borderline personality disorder	13.1	TPH1, COMT, SLC6A3
26	obsessive-compulsive disorder	13.0	TPH1, DRD3, COMT, SLC6A3
27	drug-induced hepatitis	13.0	CYP2C19, CYP2D6, CYP2C9
28	movement disease	12.9	GCH1, PARK2, FMR1, DRD3, CYP2D6, SNCA
29	mood disorder	12.9	TPH1, DRD3, COMT, SLC6A3, GABRA1
30	anxiety disorder	12.9	TPH1, CYP2D6, COMT, SLC6A3
31	variegate porphyria	12.8	ALAD, TPH1, CYP2C19, CYP2D6
32	migraine without aura	12.8	GSTP1, DRD3, COMT, SLC6A3
33	gaucher's disease	12.8	PARK2, MTHFR, ARSA, SNCA, GBA
34	fibromyalgia	12.8	LAPTM4A, CYP2D6, COMT, SLC6A3
35	eating disorder	12.8	TPH1, DRD3, CYP2D6, COMT, SLC6A3
36	cocaine dependence	12.8	GSTP1, DRD3, COMT, SLC6A3
37	schizophrenia	12.8	MTHFR, DRD3, COMT
38	sudden infant death syndrome	12.7	TPH1, CYP2C19, CYP2D6, CYP2C9, SLC6A3
39	was-related disorders	12.7	FMR1, APOB, CYP2C19, SNCA, RPGRIP1L, ADH1B
40	corpus callosum	12.7	ATXN2, SNCA, RPGRIP1L, COMT, PUM2
41	ppm-x syndrome	12.7	ARSA, TPH1, DRD3, CYP2D6, COMT, SLC6A3
42	substance abuse	12.6	DRD3, CYP2C19, CYP2D6, COMT, SLC6A3, ADH1B
43	wilson disease	12.6	MTHFR, ARSA, CYP2D6, SLC6A3
44	heroin dependence	12.6	COMT, SLC6A3, GABRA1
45	fetal akinesia syndrome x-linked	12.6	SNCA, COMT
46	restless legs syndrome	12.6	BTBD9, PARK2, ATXN2, DRD3, SNCA, COMT
47	prion disease	12.6	PARK2, SCN8A, APOB, TPH1, SNCA, SLC6A3
48	tourette syndrome	12.6	GCH1, BTBD9, DRD3, COMT, SLC6A3
49	phenylketonuria	12.6	GCH1, MTHFR, TPH1, SLC6A3
50	substance dependence	12.6	GSTP1, TPH1, DRD3, COMT, SLC6A3

Clinical features from OMIM: 190300

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 propranolol, propranolol hydrochloride

Genetic tests related to essential tremor:

id	Genetic test	Affiliating Genes
1	Essential Tremor clinical/research	DRD3

MalaCards organs/tissues related to essential tremor:

²²

MGI Mouse Phenotypes related to essential tremor:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	8.3	GABRA4, GBA, SLC6A3, LRRK2, SNCA, TPH1
2	nervous system phenotype	MP:0003631	7.5	LINGO1, GABRQ, GBA, SLC6A3, LRRK2, COMT
3	behavior/neurological phenotype	MP:0005386	6.5	SNCA, COMT, LRRK2, SLC6A3, GBA, GABRA1

Articles related to essential tremor:

(show top 50)    (show all 55)

id	Title	Authors	Year	Affiliating Genes
1	Lingo2 variants associated with essential tremor and Parkinson's disease. (21287203)	Wu Y.W.... Tan E.K.	2011	LINGO2
2	Gamma-aminobutyric acid GABRA4, GABRE, and GABRQ rece ptor polymorphisms and risk for essential tremor. (21422964)	GarcA-a-MartA-n E.... JimAcnez-JimAcnez F.J.	2011	GABRA4, GABRE, GABRQ
3	Mutations in the Parkinson's disease genes, Leucine R ich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated wi th essential tremor. (19527940)	Clark L.N.... Louis E.D.	2010	GBA, LRRK2
4	Imaging essential tremor. (20437537)	Isaias I.U.... Antonini A.	2010	SLC6A3
5	No association with the ETM2 locus in Czech patients with familial essential tremor. (20802447)	Zahorakova D.... Ruzicka E.	2010	ETM2
6	Screening for two SNPs of LINGO1 gene in patients wit h essential tremor or sporadic Parkinson's disease in Chinese population. (20600614)	Zuo X.... Tang B.S.	2010	LINGO1
7	Histamine N-methyltransferase Thr105Ile is not associ ated with Parkinson's disease or essential tremor. (19773194)	Keeling B.H.... Farrer M.J.	2010	HNMT
8	Gamma-aminobutyric acid (GABA) receptor rho (GABRR) p olymorphisms and risk for essential tremor. (20820800)	GarcA-a-MartA-n E.... JimAcnez-JimAcnez F.J.	2010	GABARAP, GABRR2, GABRR1
9	LINGO1 rs9652490 is associated with essential tremor and Parkinson disease. (19720553)	VilariA+o-GA1ell C.... Farrer M.J.	2010	LINGO1
10	Dopamine receptor D3 (DRD3) genotype and allelic vari ants and risk for essential tremor. (19645064)	GarcA-a-MartA-n E.... JimAcnez-JimAcnez F.J.	2009	DRD3
11	Common mutations in the LRRK2 exon 41 are not responsible for essential tremor in Italian patients. (18556235)	Vitale C.... Mandich P.	2009	LRRK2
12	Variant in the sequence of the LINGO1 gene confers risk of essential tremor. (19182806)	Stefansson H.... Stefansson K.	2009	LINGO1
13	The Nonsynonymous Thr105Ile Polymorphism of the Histamine N-Methyltransferase is Associated to the Risk of Developing Essential Tremor. (18543121)	Ledesma M.C.... Agundez J.A.	2008	HNMT
14	Essential tremor and the common LRRK2 G2385R variant. (18316234)	Tan E.K.... Zhao Y.	2008	LRRK2
15	Case-control study of patients with essential tremor in Latvia. (18637033)	Inashkina I.... Jankevics E.	2008	DRD3
16	Glutathione-S-transferase P1 polymorphism and risk for essential tremor. (18215156)	Martinez C.... Jimenez-Jimenez F.J.	2008	GSTP1
17	Evaluation of SCN8A as a candidate gene for autosomal dominant essential tremor. (18718804)	Sharkey L.M.... Meisler M.H.	2008	SCN8A
18	Striatal dopamine transporter abnormalities in patients with essential tremor. (18317299)	Isaias I.U.... Antonini A.	2008	SLC6A3
19	Brain parenchyma sonography and 123I-FP-CIT SPECT in Parkinson's disease and essential tremor. (18067184)	Doepp F.... Schreiber S.J.	2008	SLC6A3
20	DRD3 Ser9Gly variant is not associated with essential tremor in a series of Italian patients. (18484990)	Vitale C.... Mandich P.	2008	DRD3
21	Dopamine transporter immunoreactivity in peripheral blood lymphocytes discriminates Parkinson's disease from essential tremor. (17260170)	Pellicano C.... Pontieri F.E.	2007	SLC6A3
22	Changes at the CYP2C locus and disruption of CYP2C8/9 linkage disequilibrium in patients with essential tremor. (17627038)	Martinez C.... Agundez J.A.	2007	CYP2C8, CYP2C9
23	A family with Parkinson disease, essential tremor, bell palsy, and parkin mutations. (17353387)	Deng H.... Jankovic J.	2007	PARK2, HS1BP3
24	Alcohol dehydrogenase 2 genotype and allelic variants are not associated with the risk for essential tremor. (17762315)	Martinez C.... Jimenez-Jimenez F.J.	2007	ADH1B
25	Genetic analysis of SCA 2 and 3 repeat expansions in essential tremor and atypical Parkinsonism. (17712857)	Tan E.K.... Zhao Y.	2007	ATXN2
26	Association of the polymorphism in alpha-2 macroglobulin gene with essential tremor and Parkinson's disease (16456795)	Xiao Y.... Zhang B.S.	2006	A2M
27	Genetic analysis of the GABRA1 gene in patients with essential tremor. (16530959)	Deng H.... Jankovic J.	2006	GABRA1
28	A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor. (16809426)	Jeanneteau F.... Sokoloff P.	2006	DRD3
29	Carbenoxolone and mefloquine suppress tremor in the harmaline mouse model of essential tremor. (16773639)	Martin F.C.... Handforth A.	2006	GJD2
30	CYP2C19 polymorphism and risk for essential tremor. (16960452)	Alonso-Navarro H.... Jimenez-Jimenez F.J.	2006	CYP2C19
31	The LRRK2 I2012T, G2019S and I2020T mutations are not common in patients with essential tremor. (16939701)	Deng H.... Jankovic J.	2006	LRRK2
32	Interaction between blood lead concentration and delta-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor. (15954127)	Louis E.D.... Bhat H.K.	2005	ALAD
33	A variant in the HS1-BP3 gene is associated with fami lial essential tremor. (15699368)	Higgins J.J.... Rooney J.P.	2005	TPH1, HS1BP3
34	Frequent sequence variation at the ETM2 locus and its association with sporadic essential tremor in Korea. (16092108)	Kim J.H.... Chang J.W.	2005	ETM2
35	Extended study of A265G variant of HS1BP3 in essential tremor and Parkinson disease. (16116142)	Deng H.... Jankovic J.	2005	HS1BP3
36	Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor. (15261877)	Pigullo S.... Mandich P.	2004	PARK2
37	Association of the C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene in patients with essential tremor in Turkey. (15390052)	Sazci A.... Bayulkem K.	2004	MTHFR
38	Haplotype analysis at the ETM2 locus in a Singaporean sample with familial essential tremor. (15355439)	Higgins J.J.... Rooney J.P.	2004	APOB, ETM2
39	Integrated physical map of the human essential tremor gene region (ETM2) on chromosome 2p24.3-p24.2. (15108195)	Higgins J.J.... Ruszczyk M.U.	2004	ETM2
40	Screen for expanded FMR1 alleles in patients with essential tremor. (15300658)	Garcia Arocena D.... Hagerman P.J.	2004	FMR1
41	Essential tremor is not associated with alpha-synuclein gene haplotypes. (12815663)	Pigullo S.... Mandich P.	2003	SNCA
42	The status of dopamine nerve terminals in Parkinson's disease and essential tremor: a PET study with the tracer [11-C]FE-CIT. (11487195)	Antonini A.... Fazio F.	2001	SLC6A3
43	No evidence of association between CAG expansions and essential tremor in a large cohort of Italian patients. (11341481)	Pigullo S.... Mandich P.	2001	DRD3, ETM1
44	Medical treatment of essential tremor and Parkinson's disease. (9597979)	Uitti R.J.	1998	COMT
45	123I]beta-CIT and SPECT in essential tremor and Park inson's disease. (9928890)	Asenbaum S.... BrA1cke T.	1998	SLC6A3
46	A gene (ETM) for essential tremor maps to chromosome 2p22-p25. (9399207)	Higgins J.J.... Nee L.E.	1997	ETM2
47	CYP2D6 polymorphism is not associated with essential tremor. (9286632)	Agundez J.A.... Benitez J.	1997	CYP2D6
48	Mapping of a familial essential tremor gene, FET1, to chromosome 3q13. (9288103)	Gulcher J.R.... Stefansson K.	1997	DRD3, ETM1
49	Arylsulphatase A (ASA) activity in parkinsonism and symptomatic essential tremor. (7913281)	Martinelli P.... Sangiorgi S.	1994	ARSA
50	Linkage analysis with chromosome 9 markers in hereditary essential tremor. (8341306)	Conway D.... Harding A.E.	1993	ASS1

Genes related to essential tremor according to GeneCards:

(show top 50)    (show all 51)

id	Symbol	Description	Score	GeneCards Section Context
1	DRD3	dopamine receptor D3	11.1	Publications, Aliases & Descriptions, Summaries
2	ETM2	essential tremor 2	11.1	Aliases & Descriptions, Publications
3	ETM1	essential tremor 1	11.1	Publications, Aliases & Descriptions
4	LRRK2	leucine-rich repeat kinase 2	11.0	Publications
5	FMR1	fragile X mental retardation 1	11.0	Publications
6	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
7	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
8	PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	11.0	Publications
9	HS1BP3	HCLS1 binding protein 3	11.0	Publications
10	LINGO1	leucine rich repeat and Ig domain containing 1	11.0	Publications
11	GJD2	gap junction protein, delta 2, 36kDa	11.0	Publications
12	GABRQ	gamma-aminobutyric acid (GABA) A receptor, theta	11.0	Publications
13	LINGO4	leucine rich repeat and Ig domain containing 4	11.0
14	PRRT2	proline-rich transmembrane protein 2	11.0
15	GABARAP	GABA(A) receptor-associated protein	11.0	Publications
16	LAPTM4A	lysosomal protein transmembrane 4 alpha	11.0
17	GABRE	gamma-aminobutyric acid (GABA) A receptor, epsilon	11.0	Publications
18	SYT12	synaptotagmin XII	11.0	Disorders
19	MANF	mesencephalic astrocyte-derived neurotrophic factor	11.0
20	GABRR3	gamma-aminobutyric acid (GABA) A receptor, rho 3	11.0	Publications
21	HNMT	histamine N-methyltransferase	11.0	Publications
22	XPNPEP3	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	11.0
23	GABRR1	gamma-aminobutyric acid (GABA) A receptor, rho 1	11.0	Publications
24	GABRR2	gamma-aminobutyric acid (GABA) A receptor, rho 2	11.0	Publications
25	GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	11.0	Publications
26	ALAD	aminolevulinate dehydratase	11.0	Publications
27	ARSA	arylsulfatase A	11.0	Publications
28	ATP13A2	ATPase type 13A2	11.0
29	ATXN2	ataxin 2	11.0	Publications
30	RPGRIP1L	RPGRIP1-like	11.0
31	ASS1	argininosuccinate synthase 1	11.0	Publications
32	SCN8A	sodium channel, voltage gated, type VIII, alpha subunit	11.0	Publications
33	CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	11.0	Publications
34	PUM2	pumilio homolog 2 (Drosophila)	11.0
35	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	11.0	Publications
36	GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	11.0	Publications
37	A2M	alpha-2-macroglobulin	11.0	Publications
38	TPH1	tryptophan hydroxylase 1	11.0	Publications
39	GBA	glucosidase, beta, acid	11.0	Publications
40	CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	11.0	Publications
41	CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	11.0	Publications
42	GCH1	GTP cyclohydrolase 1	11.0
43	GIGYF2	GRB10 interacting GYF protein 2	11.0
44	CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	11.0	Publications
45	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
46	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
47	GSTP1	glutathione S-transferase pi 1	11.0	Publications
48	BTBD9	BTB (POZ) domain containing 9	11.0
49	COMT	catechol-O-methyltransferase	11.0	Publications
50	LINGO2	leucine rich repeat and Ig domain containing 2	11.0	Publications

Pathways related to essential tremor according to GeneDecks:

(show all 36)

id	Pathway	Score	Top Affiliating Genes
1	GABA signaling in brain10	10.2	GABRA4, GABRA1, GABRQ, GABRE
2	Celecoxib Pathway, Pharmacokinetics34	10.1	ADH1B, CYP2C9, CYP2D6
3	Neuronal System38	10.0	GJD2, GABRR2, GABRR1, GABRA4, GABRA1, GABRR3
4	Cyclophosphamide Pathway, Pharmacokinetics34	10.0	CYP2C9, CYP2C8, CYP2C19
5	Warfarin Pathway, Pharmacokinetics34	10.0	CYP2C19, CYP2C8, CYP2C9
6	Estrogen biosynthesis41	10.0	CYP2C9, CYP2C8, CYP2C19
7	Fluoxetine Pathway, Pharmacokinetics34	9.9	CYP2C9, CYP2D6, CYP2C19
8	Estrogen biosynthesis10	9.9	CYP2C9, CYP2C8, CYP2C19
9	Gefitinib Pathway, Pharmacokinetics34	9.9	CYP2C19, CYP2D6, CYP2C9
10	Rosiglitazone Pharmacokinetic Pathway34	9.9	CYP2C8, CYP2C9
11	Neuroactive ligand-receptor interaction20	9.9	GABRR2, GABRR1, GABRA4, GABRA1, GABRQ, GABRE
12	Sperm Motility36	9.9	GABRE, GABRQ, GABRR3, GABRA1, GABRA4, GABRR1
13	Imipramine/Desipramine Pathway, Pharmacokinetics34	9.9	CYP2C19, CYP2D6
14	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics34	9.9	CYP2C9, CYP2D6, CYP2C19
15	Benzo[a]pyrene metabolism41	9.8	CYP2C9, CYP2C8, GSTP1
16	Benzo[a]pyrene metabolism10	9.8	CYP2C9, CYP2C8, GSTP1
17	Neuroscience3	9.8	LRRK2, SNCA, GSTP1, FMR1, ATP13A2, PARK2
18	Fluvastatin Pathway, Pharmacokinetics34	9.8	CYP2C19, CYP2C8, CYP2D6, CYP2C9
19	Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics34	9.8	CYP2C9, CYP2D6, CYP2C8, CYP2C19
20	Statin Pathway - Generalized, Pharmacokinetics34	9.8	CYP2C19, CYP2C8, CYP2D6, CYP2C9
21	Tamoxifen Pathway, Pharmacokinetics34	9.8	CYP2C9, CYP2D6, CYP2C19
22	Retinol metabolism10	9.7	CYP2C9, CYP2D6, CYP2C8, CYP2C19
23	Retinol metabolism41	9.7	CYP2C9, CYP2D6, CYP2C8, CYP2C19
24	Naphthalene metabolism41	9.6	CYP2C9, CYP2C8, GSTP1
25	Retinol metabolism20	9.6	CYP2C19, CYP2C8, CYP2C9, ADH1B
26	Biological oxidations38	9.6	ADH1B, CYP2C9, CYP2D6, CYP2C8, CYP2C19
27	Clomipramine Pathway, Pharmacokinetics34	9.6	CYP2C19, CYP2D6
28	Naphthalene metabolism10	9.5	CYP2C9, CYP2C8, GSTP1
29	Estrone metabolism41	9.4	COMT, CYP2C9, CYP2C19
30	Estrone metabolism10	9.4	COMT, CYP2C9, CYP2C19
31	Metabolism of xenobiotics by cytochrome P45020	9.3	GSTP1, CYP2C19, CYP2C8, CYP2C9, ADH1B
32	Estradiol metabolism41	9.2	COMT, CYP2C9, CYP2D6, CYP2C8, CYP2C19
33	Estradiol metabolism10	9.2	COMT, CYP2C9, CYP2D6, CYP2C8, CYP2C19
34	Phenytoin Pathway, Pharmacokinetics34	9.2	COMT, CYP2C9, CYP2D6, CYP2C8, CYP2C19
35	Drug metabolism - cytochrome P45020	9.1	ADH1B, CYP2C9, CYP2D6, CYP2C8, CYP2C19, GSTP1
36	Metabolic pathways20	7.4	CYP2C9, COMT, ADH1B, GBA, CYP2C8, CYP2C19

Compounds related to essential tremor according to GeneDecks:

(show top 50)    (show all 268)

id	Compound	Score	Top Affiliating Genes
1	clozapine32 34 9 9	13.1	DRD3, CYP2C8, CYP2C9, SLC6A3
2	Halazepam9 9	11.1	GABRE, GABRR3, GABRA1, GABRR1, GABRR2
3	Fludiazepam9 9	11.1	GABRR3, GABRE, GABRR2, GABRA1, GABRR1
4	Cinolazepam9 9	11.1	GABRR2, GABRR3, GABRA1, GABRE, GABRR1
5	Prazepam9 9	11.1	GABRE, GABRR3, GABRR2, GABRA1, GABRR1
6	estazolam32 9 9	12.1	GABRR2, GABRR1, GABRA1, GABRE, GABRR3
7	Clorazepate9 9	10.9	GABRE, GABRQ, GABRR3, GABRA1, GABRA4, GABRR1
8	Oxazepam9 9	10.9	GABRE, GABRR1, GABRQ, GABRR2, GABRA1, GABRR3
9	nitrazepam32 9 9	11.9	GABRE, GABRQ, GABRR3, GABRA1, GABRA4, GABRR1
10	flurazepam32 9 9	11.9	GABRA4, GABRE, GABRR3, GABRA1, GABRQ, GABRR1
11	lorazepam32 34 9 9	12.9	GABRR3, GABRR2, GABRR1, GABRA4, GABRA1, GABRE
12	clonazepam32 9 9	11.9	GABRE, GABRQ, GABRR1, GABRR2, GABRR3, GABRA1
13	muscimol32 42	10.9	GABRR3, GABRE, GABRQ, GABRA1, GABRA4, GABRR2
14	Adinazolam9 9	10.8	GABRR3, GABRA1, GABRE, GABRR1, CYP2C19, GABRR2
15	Clotiazepam9 9	10.8	GABRA1, GABRR2, GABRR3, GABRE, CYP2C19, GABRR1
16	chlordiazepoxide32 9 9	11.7	CYP2D6, GABRE, GABRQ, GABRA1, GABRA4, GABRR1
17	amodiaquine32 9 9	11.6	CYP2D6, HNMT, CYP2C19, CYP2C8, CYP2C9
18	bupropion32 34 9 18 9	13.6	DRD3, SLC6A3, CYP2C9, CYP2D6, CYP2C8, CYP2C19
19	clobazam34 32 9 9	12.6	GABRA4, GABRR1, GABRR3, GABRQ, GABRE, GABRR2
20	bromazepam32 9 9	11.6	GABRR1, GABRA1, GABRR2, GABRA4, CYP2C19, GABRE
21	primidone32 9 9	11.6	CYP2C19, GABRA4, CYP2C9, CYP2C8, GABRA1
22	nicotine32 34 9 9	12.6	CYP2C9, CYP2D6, CYP2C19, CYP2C8
23	quazepam32 9 9	11.5	GABRR2, GABRR1, GABRA1, GABRR3, GABRE, CYP2C9
24	chlorine32 18	10.5	GABRA4, GABRR1, GABRR2, GABRR3, GABRE, GABRQ
25	hexobarbital32 9 9	11.5	CYP2C19, CYP2C9, GABRA1, GABRA4, CYP2D6
26	fluvoxamine32 34 9 9	12.5	TPH1, SLC6A3, CYP2C9, CYP2C19, CYP2D6
27	micafungin32 9 9	11.4	CYP2C19, COMT, ARSA, CYP2C9
28	Carbinoxamine9 9	10.4	CYP2C19, CYP2C9, CYP2C8, CYP2D6
29	mptp32	9.4	SLC6A3, DRD3, PARK2, SNCA, COMT, GCH1
30	methamphetamine32 9 9	11.4	DRD3, SLC6A3, COMT, SNCA, CYP2D6, TPH1
31	citalopram32 34 9 18 9	13.4	CYP2C9, CYP2D6, CYP2C8, CYP2C19, TPH1, SLC6A3
32	alprazolam32 9 9	11.3	CYP2C19, CYP2C9, GABRE, GABRR2, GABRR1, GABRA4
33	diazepam32 34 9 9	12.2	GABRR2, CYP2C8, CYP2C9, GABARAP, GABRE, GABRQ
34	Temazepam9 9	10.1	CYP2C19, CYP2C8, CYP2C9, GABRE, GABRR2, GABRA4
35	triazolam32 9 9	11.1	GABRR2, GABRR1, GABRA4, GABRA1, GABRR3, GABRQ
36	olanzapine32 34 9 18 9	13.0	SLC6A3, CYP2C19, COMT, CYP2C9, CYP2D6, DRD3
37	selegiline32 9 9	11.0	CYP2D6, SNCA, COMT, CYP2C8, CYP2C19, CYP2C9
38	thiopurine32	9.0	CYP2C9, MTHFR, GSTP1, HNMT, CYP2C19, CYP2D6
39	gaba32 42	10.0	GABARAP, FMR1, GJD2, TPH1, SLC6A3, GABRR3
40	midazolam32 9 9	10.9	CYP2C8, GABRR1, GABRA4, GABRA1, GABRR3, GABRQ
41	paroxetine32 34 9 9	11.8	TPH1, CYP2C8, CYP2D6, SLC6A3, CYP2C9, COMT
42	cocaine32 9 9	10.7	SNCA, VIM, DRD3, CYP2C8, CYP2D6, SLC6A3
43	imipramine32 34 9 18 9	12.7	GSTP1, DRD3, CYP2C19, CYP2D6, CYP2C9, SLC6A3
44	catecholamine32	8.7	PARK2, GCH1, VIM, COMT, SNCA, DRD3
45	dopamine32 9 18 9	11.3	COMT, ADH1B, MTHFR, SLC6A3, GCH1, PARK2
46	estrone32 9 18 9	11.3	ARSA, CYP2C19, CYP2D6, CYP2C9, COMT, APOB
47	levodopa32 9 9	10.3	GCH1, PARK2, MTHFR, CYP2D6, GSTP1, TPH1
48	choline32 9 18 9	11.2	ADH1B, SLC6A3, COMT, SNCA, TPH1, APOB
49	valine32	7.8	SLC6A3, VIM, ARSA, TPH1, GSTP1, SNCA
50	testosterone32 9 18 9	10.0	SNCA, COMT, CYP2C9, ALAD, APOB, CYP2D6

Cellular components related to essential tremor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	postsynaptic membrane	GO:045211	9.5	GABRR1, GABRA4, GABRA1, GABRR3, GABRQ, GABRE
2	chloride channel complex	GO:034707	9.4	GABRE, GABRR2, GABRR1, GABRA4, GABRA1, GABRR3
3	cell junction	GO:030054	9.0	GABRR2, GABRR1, GABRA4, GABRA1, GABRR3, GABRQ

Biological processes related to essential tremor according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of locomotion	GO:040012	10.5	LRRK2, SNCA, DRD3
2	dopamine biosynthetic process	GO:042416	10.2	GCH1, SNCA, SLC6A3
3	response to cocaine	GO:042220	10.2	SLC6A3, DRD3, HNMT
4	positive regulation of dopamine receptor signaling pathway	GO:060161	10.0	DRD3, LRRK2
5	ion transmembrane transport	GO:034220	10.0	GABRR2, GABRR1, GABRA4, GABRA1, GABRR3
6	gamma-aminobutyric acid signaling pathway	GO:007214	9.9	GABRE, GABRR3, GABRA1, GABRA4, GABRR1, GABRR2
7	oxidative demethylation	GO:070989	9.9	CYP2C9, CYP2D6, CYP2C8
8	monoterpenoid metabolic process	GO:016098	9.8	CYP2C19, CYP2D6, CYP2C9
9	exogenous drug catabolic process	GO:042738	9.8	CYP2C9, CYP2C8, CYP2C19
10	dopamine catabolic process	GO:042420	9.8	COMT, SLC6A3
11	transport	GO:006810	9.6	GABRR2, GABRR1, GABRA4, GABRA1, GABRE, SLC6A3
12	drug metabolic process	GO:017144	9.6	CYP2C9, CYP2D6, CYP2C8, CYP2C19
13	cell death	GO:008219	9.5	GBA, SLC6A3, GIGYF2, ATXN2, PARK2
14	oxidation-reduction process	GO:055114	9.4	SNCA, CYP2C9, CYP2D6, CYP2C8, CYP2C19
15	synaptic transmission	GO:007268	9.1	GABRR2, GABRR1, GABRA4, GABRA1, GABRR3, GABARAP
16	xenobiotic metabolic process	GO:006805	8.4	ADH1B, COMT, CYP2C9, CYP2D6, CYP2C8, CYP2C19
17	small molecule metabolic process	GO:044281	6.3	CYP2C8, CYP2D6, CYP2C9, COMT, ADH1B, GBA

Molecular functions related to essential tremor according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	(R)-limonene 6-monooxygenase activity	GO:052741	10.0	CYP2C9, CYP2C19
2	(S)-limonene 7-monooxygenase activity	GO:018676	9.9	CYP2C9, CYP2C19
3	(S)-limonene 6-monooxygenase activity	GO:018675	9.8	CYP2C9, CYP2C19
4	GABA-A receptor activity	GO:004890	9.7	GABRE, GABRR2, GABRR1, GABRA4, GABRA1, GABRR3
5	drug binding	GO:008144	9.7	GABRA1, SLC6A3, CYP2C9, CYP2D6, DRD3
6	extracellular ligand-gated ion channel activity	GO:005230	9.7	GABRR2, GABRR1, GABRA4, GABRA1, GABRR3, GABRQ
7	chloride channel activity	GO:005254	9.7	GABRR2, GABRR1, GABRA4, GABRA1, GABRR3, GABRQ
8	caffeine oxidase activity	GO:034875	9.7	CYP2C8, CYP2C9
9	monooxygenase activity	GO:004497	9.5	CYP2C19, CYP2C8, CYP2D6, CYP2C9
10	oxidoreductase activity	GO:016491	9.5	CYP2C19, CYP2D6, CYP2C9, SNCA
11	iron ion binding	GO:005506	9.0	CYP2C9, CYP2D6, CYP2C8, CYP2C19, TPH1