MCID: ESS001
MIFTS: 58

Essential Tremor

Categories: Rare diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Essential Tremor

MalaCards integrated aliases for Essential Tremor:

Name: Essential Tremor 12 49 24 50 36 28 51 41 14 69
Benign Essential Tremor 12 49 24
Hereditary Essential Tremor 49 24
Familial Tremor 24 69
Essential Tremor, Susceptibility to 13
Benign Essential Tremor Syndrome 72
Tremor, Hereditary Essential, 1 49
Essential Hereditary Tremor 12
Tremor Hereditary Essential 72
Familial Essential Tremor 49
Presenile Tremor Syndrome 49
Shaky Hand Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4990
ICD10 32 G25.0
MeSH 41 D020329
KEGG 36 H01577

Summaries for Essential Tremor

NINDS : 50 Tremor is an unintentional, somewhat rhythmic, muscle movement involving to-and-fro movements (oscillations) of one or more parts of the body. Essential tremor (previously called benign essential tremor) is the most common form of abnormal tremor. (In some people, tremor is a symptom of a neurological disorder or appears as a side effect of certain drugs.)  Although it may be mild and nonprogressive in some people, in others the tremor is slowly progressive, starting on one side of the body but eventually affecting both sides. Hand tremor is most common but the head, arms, voice, tongue, legs, and trunk may also be involved. Hand tremor may cause problems with purposeful movements such as eating, writing, sewing, or shaving. Head tremor may be seen as a "yes-yes" or "no-no" motion. Essential tremor may be accompanied by mild gait disturbance. Heightened emotion, stress, fever, physical exhaustion, or low blood sugar may trigger tremors or increase their severity. There may be mild degeneration in the certain parts of the cerebellum in persons with essential tremor.  Onset is most common after age 40, although symptoms can appear at any age. Children of a parent who has essential tremor have up to a 50 percent chance of inheriting the condition. Essential tremor is not associated with any known pathology.

MalaCards based summary : Essential Tremor, also known as benign essential tremor, is related to tremor and multiple system atrophy 1, and has symptoms including tremor, essential and other specified forms of tremor and physiological tremor. An important gene associated with Essential Tremor is ETM2 (Essential Tremor 2), and among its related pathways/superpathways are Neuroscience and Parkinsons Disease Pathway. The drugs Dopamine and Pregabalin have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and tongue, and related phenotype is nervous system.

NIH Rare Diseases : 49 Essential tremor is the most common movement disorder.  It is characterized by involuntary and rhythmic shaking (tremor), especially in the hands, without any other signs or symptoms. It is distinguished from tremor that results from other disorders or known causes, such as tremors seen with Parkinson disease or head trauma. Most cases of essential tremor are hereditary. There are five forms of essential tremor that are based on different genetic causes. Several genes as well as lifestyle and environmental factors likely play a role in a person's risk of developing this complex condition. In mild cases, treatment may not be necessary. In cases where symptoms interfere with daily living, medications may help to relieve symptoms.      Last updated: 9/12/2014

Genetics Home Reference : 24 Essential tremor is a movement disorder that causes involuntary, rhythmic shaking (tremor), especially in the hands. It is distinguished from tremor that results from other disorders or known causes, such as Parkinson disease or head trauma. Essential tremor usually occurs alone, without other neurological signs or symptoms. However, some experts think that essential tremor can include additional features, such as mild balance problems.

Disease Ontology : 12 A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms.

Wikipedia : 72 Essential tremor (ET, also referred to as benign tremor, familial tremor, or idiopathic tremor) is the... more...

Related Diseases for Essential Tremor

Diseases in the Tremor family:

Tremor, Hereditary Essential, 1 Tremor, Hereditary Essential, 2
Tremor, Hereditary Essential, 3 Tremor, Hereditary Essential, 4
Tremor, Hereditary Essential, 5 Essential Tremor

Diseases related to Essential Tremor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 tremor 30.5 CHCHD2 DRD3 FMR1 FUS HTRA2 LRRK2
2 multiple system atrophy 1 29.8 LRRK2 PRKN SLC6A3 SNCA
3 restless legs syndrome 29.8 DRD3 PRKN SLC6A3 SNCA
4 supranuclear palsy, progressive, 1 29.6 LRRK2 PRKN SLC6A3 SNCA
5 parkinson disease, late-onset 29.4 CHCHD2 DRD3 LRRK2 PRKN SLC6A3 SNCA
6 sensorineural hearing loss-early graying-essential tremor syndrome 12.1
7 tremor, hereditary essential, 1 12.0
8 tremor, hereditary essential, 5 11.6
9 tremor, hereditary essential, 2 11.4
10 tremor, nystagmus, and duodenal ulcer 11.1
11 tremor, hereditary essential, 3 11.1
12 tremor, hereditary essential, 4 11.1
13 mental retardation, autosomal recessive 48 11.1
14 nephronophthisis-like nephropathy 1 10.9
15 x-linked dystonia-parkinsonism/lubag 10.9
16 dystonia 10.3
17 hereditary late-onset parkinson disease 10.2 LRRK2 SNCA
18 aging 10.2
19 dysautonomia 10.1 PRKN SNCA
20 bell's palsy 10.1 HS1BP3 PRKN
21 postencephalitic parkinson disease 10.1 LRRK2 SNCA
22 rem sleep behavior disorder 10.1 LRRK2 SLC6A3 SNCA
23 cervical dystonia 10.1
24 cervicitis 10.1
25 parkinson disease 10 10.1 LRRK2 PRKN SNCA
26 parkinson disease 3, autosomal dominant 10.1 LRRK2 PRKN SNCA
27 ataxia and polyneuropathy, adult-onset 10.1
28 leukoencephalopathy, hereditary diffuse, with spheroids 10.1 SLC1A2 SNCA
29 toxic encephalopathy 10.1 SLC1A2 SLC6A3 SNCA
30 alzheimer disease 10.0
31 early-onset parkinson disease 10.0 LRRK2 PRKN SNCA
32 parkinson disease 15, autosomal recessive early-onset 10.0 LRRK2 PRKN SNCA
33 dementia 10.0
34 neuronitis 10.0
35 striatonigral degeneration 9.9 SLC6A3 SNCA
36 disease of mental health 9.9 DRD3 FMR1 SLC6A3 SNCA
37 parkinson disease 2, autosomal recessive juvenile 9.9 HTRA2 LRRK2 PRKN SNCA
38 synucleinopathy 9.9 LRRK2 PRKN SLC6A3 SNCA
39 dementia, lewy body 9.9 LRRK2 PRKN SLC6A3 SNCA
40 migraine with or without aura 1 9.8
41 polykaryocytosis inducer 9.8
42 glass syndrome 9.8
43 sarcoma 9.8
44 autosomal dominant cerebellar ataxia 9.8
45 cerebritis 9.8
46 classic progressive supranuclear palsy syndrome 9.8
47 central nervous system disease 9.8 LRRK2 PRKN SLC6A3 SNCA
48 nervous system disease 9.7 FUS LRRK2 PRKN SLC6A3 SNCA
49 amyotrophic lateral sclerosis 1 9.7
50 obsessive-compulsive disorder 9.7

Graphical network of the top 20 diseases related to Essential Tremor:



Diseases related to Essential Tremor

Symptoms & Phenotypes for Essential Tremor

UMLS symptoms related to Essential Tremor:


tremor, essential and other specified forms of tremor, physiological tremor, action tremor, senile tremor

MGI Mouse Phenotypes related to Essential Tremor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.32 LINGO1 LRRK2 PRKN SLC1A2 SLC6A3 SNCA

Drugs & Therapeutics for Essential Tremor

Drugs for Essential Tremor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
2
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
3
Memantine Approved, Investigational Phase 4 19982-08-2 4054
4
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
5
Propranolol Approved, Investigational Phase 4 525-66-6 4946
6
Iodine Approved, Investigational Phase 4 7553-56-2 807
7 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
8 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
9 Dopamine Agents Phase 4,Phase 3
10 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
11 Analgesics Phase 4,Phase 2,Phase 3
12 Anti-Anxiety Agents Phase 4
13 Anticonvulsants Phase 4,Phase 3,Phase 2,Phase 1
14 calcium channel blockers Phase 4,Phase 2
15 Calcium, Dietary Phase 4,Phase 2
16 Psychotropic Drugs Phase 4
17 Tranquilizing Agents Phase 4
18 Antiparkinson Agents Phase 4,Phase 3
19 Excitatory Amino Acid Antagonists Phase 4
20 Excitatory Amino Acids Phase 4
21 Adrenergic Agents Phase 4,Phase 2,Phase 3
22 Adrenergic Antagonists Phase 4
23 Adrenergic beta-Antagonists Phase 4
24 Anti-Arrhythmia Agents Phase 4
25 Antihypertensive Agents Phase 4
26 Botulinum Toxins Phase 4,Phase 3,Phase 2
27 Cholinergic Agents Phase 4,Phase 3,Phase 2
28 Vasodilator Agents Phase 4
29 Pharmaceutical Solutions Phase 4,Phase 2
30 cadexomer iodine Phase 4
31 Calamus Nutraceutical Phase 4
32
Cocaine Approved, Illicit Phase 3 50-36-2 446220 5760
33
Topiramate Approved Phase 3 97240-79-4 5284627
34
Dexmedetomidine Approved, Vet_approved Phase 2, Phase 3 76631-46-4, 113775-47-6 5311068 56032 68602
35 Anesthetics Phase 3,Phase 2
36 Anesthetics, Local Phase 3
37 Dopamine Uptake Inhibitors Phase 3
38 Neurotransmitter Uptake Inhibitors Phase 3
39 Vasoconstrictor Agents Phase 3
40 Anti-Obesity Agents Phase 3
41 Neuroprotective Agents Phase 3,Phase 1,Phase 2
42 Protective Agents Phase 3,Phase 2,Phase 1
43 abobotulinumtoxinA Phase 3,Phase 2
44 Botulinum Toxins, Type A Phase 3,Phase 2
45 onabotulinumtoxinA Phase 3,Phase 2
46 Antioxidants Phase 3,Phase 2
47 Adrenergic Agonists Phase 2, Phase 3
48 Adrenergic alpha-2 Receptor Agonists Phase 2, Phase 3
49 Adrenergic alpha-Agonists Phase 2, Phase 3
50 Analgesics, Non-Narcotic Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 133)

# Name Status NCT ID Phase Drugs
1 Validation of DaTscan for Detection of Parkinson Disease Related Disorders Unknown status NCT02138682 Phase 4 l-123 Ioflupane
2 Pregabalin in the Treatment of Essential Tremor Completed NCT00646451 Phase 4 pregabalin;placebo capsules
3 A Pilot Clinical Trial Of Memantine for Essential Tremor Completed NCT00439699 Phase 4 Memantine
4 Pregabalin (Lyrica) for the Treatment of Essential Tremor Completed NCT00584376 Phase 4 Pregabalin;Placebo
5 Propranolol and Botulinum Toxin for Essential Vocal Tremor Completed NCT02111369 Phase 4 Propranolol
6 RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR) Completed NCT00998660 Phase 4
7 A Study to Assess Changes in Clinical Management After DaTSCAN Imaging of Subjects With Clinically Uncertain Parkinsonism or an Illness With Similar Symptoms Completed NCT00382967 Phase 4
8 Atlas Predicted DBS Settings in Essential Tremor Enrolling by invitation NCT02678429 Phase 4
9 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4 I-123 Ioflupane solution injection prior to SPECT scan (DaTscan)
10 Two Separate But Identical Studies Evaluating the Safety and Efficacy of ALTROPANE® in the Use of SPECT Imaging for Upper Extremity Tremor Unknown status NCT00724906 Phase 3 123 I - ALTROPANE®
11 Novel Therapies for Essential Tremor Completed NCT00018564 Phase 3 treatments for essential tremor
12 A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause. Completed NCT00236496 Phase 3 topiramate
13 Efficacy and Safety of F-18 FPCIT PET in Parkinson's Disease and Essential Tremor Patients Completed NCT00468078 Phase 3 F-18 FPCIT
14 Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential Tremor Recruiting NCT02555982 Phase 3 BOTOX ® 200 Unités;Placebo
15 Pre-lemniscal Radiation Deep Brain Stimulation for ET Terminated NCT00634478 Phase 2, Phase 3
16 Efficacy of Pramipexole Extended Release in the Treatment of Essential Tremor Withdrawn NCT01441284 Phase 3 pramipexole;placebo
17 Dexmedetomidine Effects on Microelectrode Recording in Deep Brain Stimulation Withdrawn NCT00608231 Phase 2, Phase 3 Dexmedetomidine Hydrochloride Infusion;Normal Saline
18 Randomised Crossover Trial of Deep Brain Stimulation of Differential Posterior Subthalamic Area Regions in Parkinson's Disease and Tremor Unknown status NCT01945567 Phase 2
19 A Pilot Efficacy and Safety Study of ST101 in Essential Tremor Completed NCT01332695 Phase 2 ST101;Placebo
20 A Study to Evaluate SAGE-217 in Subjects With Essential Tremor Completed NCT02978781 Phase 2 SAGE-217;Placebo
21 A Safety/Efficacy Trial of Zonisamide for Essential Tremor Completed NCT00223743 Phase 2 Zonisamide
22 Evaluate SAGE-547 in Patients With Essential Tremor Completed NCT02277106 Phase 2 SAGE-547;Placebo
23 Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential Tremor Completed NCT00598078 Phase 2 Sodium Oxybate;Sodium Oxybate
24 A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential Tremor Completed NCT00524056 Phase 2 Carisbamate;Placebo
25 Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential Tremor Completed NCT00848172 Phase 1, Phase 2 Octanoic Acid;Placebo
26 Efficacy of Levetiracetam in Essential Tremor Completed NCT00620165 Phase 1, Phase 2 levetiracetam;placebo
27 Octanol to Treat Essential Tremor Completed NCT00080366 Phase 2 1-Octanol
28 Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor Completed NCT00102596 Phase 2 1-Octanol
29 Botulinum Toxin A to Treat Arm Tremor Completed NCT02207946 Phase 2 IncobotulinumtoxinA;Placebo
30 Effects of Octanoic Acid for Treatment of Essential Voice Tremor Completed NCT01864525 Phase 1, Phase 2 Octanoic acid;Placebo pill
31 A Phase 2 RCT Study of CX-8998 for Essential Tremor Recruiting NCT03101241 Phase 2 CX-8998;Placebo
32 Botulinum Toxin Type A for Injection of Bilateral Upper Extremity Tremor in Patients With Essential Tremor Using Kinematic Assessment Recruiting NCT02551848 Phase 2 Botulinum toxin type A (Xeomin®)
33 Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres? Recruiting NCT02960243 Phase 1, Phase 2
34 Deep Brain Frameless Radiosurgery for Drug Resistant Invalidating Tremor. Dose Escalation Pilot Study Recruiting NCT02585583 Phase 2
35 An Efficacy/Safety Study of Perampanel for Reducing Essential Tremor Active, not recruiting NCT02668146 Phase 2 Perampanel;Placebo
36 Use of Kinematic Assessment of Hand Tremor Pre- and Post- Treatment With Botulinum Toxin Type A in Essential Tremor and Parkinson Disease Active, not recruiting NCT02427646 Phase 2 IncobotulinumtoxinA
37 T2000 in Essential Tremor - Open Label Continuation Terminated NCT00655278 Phase 2 T2000
38 A Study of T2000 in Essential Tremor Terminated NCT00321087 Phase 2 T2000;T2000;T2000
39 Octanoic Acid for Essential Tremor Completed NCT01468948 Phase 1 Octanoic Acid
40 ExAblate Transcranial MR Guided Focused Ultrasound in the Treatment of Essential Tremor Completed NCT02037217 Phase 1
41 ExAblate Transcranial MR Guided Focused Ultrasound in the Treatment of Essential Tremor Completed NCT01304758 Phase 1
42 1-Octanol to Treat Essential Tremor Completed NCT00016679 Phase 1 1-Octanol
43 1-Octanol to Treat Essential Tremor Completed NCT00001986 Phase 1 1-Octanol
44 Magnetic Resonance (MR) Guided Functional Ultrasound-Neurosurgery for Movement Disorders Completed NCT01698450 Phase 1
45 Thalamic Deep Brain Stimulation for Spasmodic Dysphonia- DEBUSSY Trial Recruiting NCT02558634 Phase 1
46 Imaging in the Diagnosis of Parkinson's Disease and Essential Tremor Unknown status NCT01446939
47 Deep Brain Stimulation (DBS) for the Suppression of Tremor Unknown status NCT02087046
48 Imaging Blood Brain Imaging Dysfunction in Parkinson's Disease Unknown status NCT02605161
49 Decision-making and Emotion Recognition in Essential Tremor Completed NCT01223144
50 Adaptive Portable Essential Tremor Monitor Completed NCT01602042

Search NIH Clinical Center for Essential Tremor

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: essential tremor

Genetic Tests for Essential Tremor

Genetic tests related to Essential Tremor:

# Genetic test Affiliating Genes
1 Essential Tremor 28

Anatomical Context for Essential Tremor

MalaCards organs/tissues related to Essential Tremor:

38
Brain, Cerebellum, Tongue, Thalamus, Cortex, Testes, Eye

Publications for Essential Tremor

Articles related to Essential Tremor:

(show top 50) (show all 740)
# Title Authors Year
1
Shaky and unsteady: Dynamic posturography in essential tremor. ( 29406890 )
2018
2
A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulation. ( 29307012 )
2018
3
Dysgeusia in deep brain stimulation for essential tremor. ( 29402567 )
2018
4
A method for characterizing essential tremor from the shoulder to the wrist. ( 29428341 )
2018
5
Essential tremor. ( 29325613 )
2018
6
Comparative Burden of Subclinical Tremor in a Cohort of Normal Individuals Stratified by Familial Risk for Essential Tremor. ( 29339654 )
2018
7
Serum concentration and clinical significance of brain-derived neurotrophic factor in patients with Parkinson's disease or essential tremor. ( 29350074 )
2018
8
A meta-analysis of outcomes and complications of magnetic resonance-guided focused ultrasound in the treatment of essential tremor. ( 29385917 )
2018
9
Pretherapeutic Functional Imaging Allows Prediction of Head Tremor Arrest After Thalamotomy for Essential Tremor: The Role of Altered Interconnectivity Between Thalamolimbic and Supplementary Motor Circuits. ( 29410136 )
2018
10
The effects of Thalamic Deep Brain Stimulation on speech dynamics in patients with Essential Tremor: An articulographic study. ( 29360867 )
2018
11
Preliminary experience with a transcranial magnetic resonance-guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson's disease. ( 29385927 )
2018
12
Double target DBS for essential tremor: 8-contact lead for cZI and vim aligned in the same trajectory. ( 29438045 )
2018
13
Inferior Olivary nucleus degeneration does not lessen tremor in essential tremor. ( 29372062 )
2018
14
Knowledge about Essential Tremor: A Study of Essential Tremor Families. ( 29434571 )
2018
15
Clinical response to Vim's thalamic stereotactic radiosurgery for essential tremor is associated with distinctive functional connectivity patterns. ( 29335882 )
2018
16
Thalamic Deep Brain Stimulation Salvages Failed Focused Ultrasound Thalamotomy for Essential Tremor: A Case Report. ( 29433124 )
2018
17
Association study of essential tremor genetic loci in Parkinson'sA disease. ( 29398123 )
2018
18
Effects on cognition and quality of life with unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. ( 29385928 )
2018
19
Topiramate for essential tremor. ( 28409827 )
2017
20
Feasibility study: Effect of hand resistance exercise on handwriting in Parkinson's disease and essential tremor. ( 28389133 )
2017
21
Heterotopic Purkinje Cells: a Comparative Postmortem Study of Essential Tremor and Spinocerebellar Ataxias 1, 2, 3, and 6. ( 28791574 )
2017
22
Emotion modulation of the startle reflex in essential tremor: Blunted reactivity to unpleasant and pleasant pictures. ( 27887893 )
2017
23
Probabilistic mapping of deep brain stimulation effects in essential tremor. ( 27981031 )
2017
24
Teneurin transmembrane protein 4 is not a cause for essential tremor in a Canadian population. ( 28158909 )
2017
25
A Network Model of Local Field Potential Activity in Essential Tremor and the Impact of Deep Brain Stimulation. ( 28068428 )
2017
26
Clinical Characteristics of Parkinson's Disease Developed from Essential Tremor. ( 28409750 )
2017
27
Role of altered cerebello-thalamo-cortical network in the neurobiology of essential tremor. ( 28062908 )
2017
28
Topography of essential tremor. ( 28442304 )
2017
29
Awareness of cognitive impairment in individuals with essential tremor. ( 28477687 )
2017
30
Equivalence of cell survival data for radiation dose and thermal dose in ablative treatments: analysis applied to essential tremor thalamotomy by focused ultrasound and gamma knife. ( 28044461 )
2017
31
Cognitive Dysfunction Is Associated with Greater Imbalance and Falls in Essential Tremor. ( 28469597 )
2017
32
Deep brain nucleus targeting in Parkinson's disease and essential tremor by image guided surgery using neuronavigation system with tractography and volume of tissue of activated assessment. ( 29324910 )
2017
33
Thalamic DBS with a constant-current device in essential tremor: AA controlled clinical trial. ( 28400200 )
2017
34
Efficacy of Fiber Tractography in the Stereotactic Surgery of the Thalamus for Patients with Essential Tremor. ( 28458383 )
2017
35
Cerebellar pathology in childhood-onset vs. adult-onset essential tremor. ( 28867587 )
2017
36
Comparative Evaluation of Magnetic Resonance-Guided Focused Ultrasound Surgery for Essential Tremor. ( 28810261 )
2017
37
Depression and social phobia in essential tremor and Parkinson's disease. ( 28948077 )
2017
38
Is Essential tremor a single entity? ( 28905504 )
2017
39
General and selective brain connectivity alterations in essential tremor: A resting state fMRI study. ( 28913163 )
2017
40
Assessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population. ( 28801652 )
2017
41
Nursing Management of the Patient Undergoing Focused Ultrasound: A New Treatment Option for Essential Tremor. ( 28817495 )
2017
42
Essential tremor & Parkinson disease: Recognizing the differences. ( 28926496 )
2017
43
Differential diagnosis between Parkinson's disease and essential tremor using the smartphone's accelerometer. ( 28841694 )
2017
44
A data mining approach using cortical thickness for diagnosis and characterization of essential tremor. ( 28526878 )
2017
45
Toward quantitative characterization of essential tremor for future tremor suppression. ( 28813814 )
2017
46
A computerized tablet system for evaluating treatment of essential tremor by magnetic resonance guided focused ultrasound. ( 28412948 )
2017
47
Differential Diagnosis of Parkinson Disease, Essential Tremor, and Enhanced Physiological Tremor with the Tremor Analysis of EMG. ( 28884038 )
2017
48
Brain positron emission tomography with 2-(18)F-2-deoxi-D-glucose of patients with dystonia and essential tremor detects differences between these disorders. ( 28805131 )
2017
49
Relationship between GWAS-linked three new loci in Essential tremor and risk of Parkinson's disease in Chinese population. ( 28807494 )
2017
50
Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles. ( 28503363 )
2017

Variations for Essential Tremor

Expression for Essential Tremor

Search GEO for disease gene expression data for Essential Tremor.

Pathways for Essential Tremor

Pathways related to Essential Tremor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.97 FMR1 LINGO1 LRRK2 PRKN SLC1A2 SNCA
2 10.95 HTRA2 LRRK2 PRKN SLC6A3 SNCA
3 10.84 PRKN SLC6A3 SNCA

GO Terms for Essential Tremor

Cellular components related to Essential Tremor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.73 FUS LRRK2 SLC6A3 SNCA
2 growth cone GO:0030426 9.58 FMR1 LRRK2 SNCA
3 perikaryon GO:0043204 9.5 FMR1 FUS LRRK2
4 presynapse GO:0098793 9.43 FMR1 PRKN SLC6A3
5 inclusion body GO:0016234 9.37 LRRK2 SNCA
6 axon GO:0030424 9.35 FMR1 LRRK2 SLC1A2 SLC6A3 SNCA
7 postsynapse GO:0098794 9.33 FMR1 LRRK2 SNCA
8 neuron projection GO:0043005 9.1 FMR1 HNMT LRRK2 PRKN SLC6A3 TENM4

Biological processes related to Essential Tremor according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.92 DRD3 SLC1A2 SLC6A3 SNCA
2 cellular response to oxidative stress GO:0034599 9.77 HTRA2 LRRK2 SNCA
3 locomotory behavior GO:0007626 9.76 DRD3 PRKN SLC6A3
4 mitochondrion organization GO:0007005 9.73 CHCHD2 HTRA2 LRRK2 PRKN
5 negative regulation of protein phosphorylation GO:0001933 9.72 LRRK2 PRKN SNCA
6 adult locomotory behavior GO:0008344 9.71 HTRA2 PRKN SNCA
7 response to cocaine GO:0042220 9.65 DRD3 SLC6A3 SNCA
8 regulation of canonical Wnt signaling pathway GO:0060828 9.64 LRRK2 PRKN
9 regulation of reactive oxygen species metabolic process GO:2000377 9.64 PRKN SNCA
10 behavioral response to cocaine GO:0048148 9.63 DRD3 SNCA
11 regulation of neuron death GO:1901214 9.63 LRRK2 SNCA
12 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.62 LRRK2 PRKN
13 positive regulation of proteasomal protein catabolic process GO:1901800 9.61 FMR1 PRKN
14 cellular protein catabolic process GO:0044257 9.61 HTRA2 PRKN
15 cellular response to dopamine GO:1903351 9.6 LRRK2 PRKN
16 prepulse inhibition GO:0060134 9.58 DRD3 SLC6A3
17 regulation of dopamine secretion GO:0014059 9.58 DRD3 PRKN SNCA
18 dopamine biosynthetic process GO:0042416 9.57 SLC6A3 SNCA
19 regulation of dopamine metabolic process GO:0042053 9.56 PRKN SLC6A3
20 synaptic transmission, dopaminergic GO:0001963 9.54 DRD3 PRKN SNCA
21 protein localization to mitochondrion GO:0070585 9.52 LRRK2 PRKN
22 cellular response to manganese ion GO:0071287 9.51 LRRK2 PRKN
23 regulation of neurotransmitter secretion GO:0046928 9.5 FMR1 PRKN SNCA
24 positive regulation of dopamine receptor signaling pathway GO:0060161 9.49 DRD3 LRRK2
25 regulation of synaptic vesicle transport GO:1902803 9.46 LRRK2 PRKN
26 negative regulation of neuron death GO:1901215 9.46 HTRA2 LRRK2 PRKN SNCA
27 dopamine metabolic process GO:0042417 9.43 DRD3 PRKN SNCA
28 regulation of locomotion GO:0040012 9.13 DRD3 LRRK2 SNCA
29 dopamine uptake involved in synaptic transmission GO:0051583 8.8 PRKN SLC6A3 SNCA

Molecular functions related to Essential Tremor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 FMR1 FUS HTRA2 LRRK2 PRKN SNCA
2 dynein complex binding GO:0070840 9.26 FMR1 SNCA
3 phospholipase binding GO:0043274 8.96 PRKN SNCA
4 dopamine binding GO:0035240 8.62 DRD3 SLC6A3

Sources for Essential Tremor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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