MCID: ESS001
MIFTS: 61

Essential Tremor malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Blood diseases

Aliases & Classifications for Essential Tremor

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Aliases & Descriptions for Essential Tremor:

Name: Essential Tremor 51 11 47 25 48 26 49 38 13 67
Benign Essential Tremor 11 47 25
Tremor, Hereditary Essential, 1 47 67
Tremor, Hereditary Essential 1 69 26
Hereditary Essential Tremor 47 25
Familial Tremor 25 67
Etm1 47 69
Essential Tremor, Susceptibility to 12
 
Tremor Hereditary Essential, 1 47
Hereditary Essential Tremor 1 24
Tremor Familial Essential, 1 47
Essential Hereditary Tremor 11
Presenile Tremor Syndrome 47
Familial Essential Tremor 47
Shaky Hand Syndrome 11
Fet1 47

Characteristics:

HPO:

63
essential tremor:
Inheritance: autosomal dominant inheritance
Onset and clinical course: progressive

Classifications:



External Ids:

OMIM51 190300
Disease Ontology11 DOID:4990
ICD1029 G25.0
MeSH38 D020329
MedGen36 C1860861

Summaries for Essential Tremor

About this section
OMIM:51 Essential tremor may be the most common human movement disorder. The main feature of essential tremor is postural... (190300) more...

MalaCards based summary: Essential Tremor, also known as benign essential tremor, is related to hereditary essential tremor 5 and sensorineural hearing loss-early graying-essential tremor syndrome, and has symptoms including dysarthria, postural tremor and hand tremor. An important gene associated with Essential Tremor is DRD3 (Dopamine Receptor D3), and among its related pathways are Alpha-synuclein signaling and Parkinsons Disease Pathway. The drugs propranolol and propranolol hydrochloride have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and cortex, and related mouse phenotypes are integument and cellular.

Disease Ontology:11 A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms.

Genetics Home Reference:25 Essential tremor is a movement disorder that causes involuntary, rhythmic shaking (tremor), especially in the hands. It is distinguished from tremor that results from other disorders or known causes, such as Parkinson disease or head trauma. Essential tremor usually occurs alone, without other neurological signs or symptoms. However, some experts think that essential tremor can include additional features, such as mild balance problems.

NIH Rare Diseases:47 Essential tremor is the most common movement disorder.  It is characterized by involuntary and rhythmic shaking (tremor), especially in the hands, without any other signs or symptoms. It is distinguished from tremor that results from other disorders or known causes, such as tremors seen with Parkinson disease or head trauma. Most cases of essential tremor are hereditary. There are five forms of essential tremor that are based on different genetic causes. Several genes as well as lifestyle and environmental factors likely play a role in a person's risk of developing this complex condition. In mild cases, treatment may not be necessary. In cases where symptoms interfere with daily living, medications may help to relieve symptoms.      Last updated: 9/12/2014

NINDS:48 Tremor is an unintentional, somewhat rhythmic, muscle movement involving to-and-fro movements (oscillations) of one or more parts of the body. Essential tremor (previously called benign essential tremor) is the most common form of abnormal tremor. (In some people, tremor is a symptom of a neurological disorder or appears as a side effect of certain drugs.)

UniProtKB/Swiss-Prot:69 Tremor, hereditary essential 1: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.

Wikipedia:70 Essential tremor (ET, also referred to as benign tremor, familial tremor, or idiopathic tremor) is the... more...

Related Diseases for Essential Tremor

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Diseases in the Tremor family:

Tremor, Hereditary Essential, 2 essential tremor
Tremor, Hereditary Essential, 3 Tremor, Hereditary Essential, 4
Hereditary Essential Tremor 5

Diseases related to Essential Tremor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary essential tremor 512.0
2sensorineural hearing loss-early graying-essential tremor syndrome12.0
3tremor11.6
4mental retardation, autosomal recessive 4811.0
5tremor, hereditary essential, 411.0
6tremor, nystagmus, and duodenal ulcer11.0
7nephronophthisis-like nephropathy 110.8
8intermittent explosive disorder10.4DRD3, SLC6A3
9parkinson disease 6, early onset10.3LRRK2, PARK2
10anti-p200 pemphigoid10.3LRRK2, SNCA
11hallucinogen dependence10.3DRD3, SLC6A3
12epileptic hemiplegia10.2PARK2, SNCA
13dystonia10.2
14retinal perforation10.2HS1BP3, PARK2
15klippel-feil syndrome 4, autosomal recessive, with myopathy and facial dysmorphism10.2PARK2, SNCA
16coenzyme q10 deficiency, primary, 110.2PARK2, SNCA
17bladder mixed adenocarcinoma10.2SLC6A3, SNCA
18irritant dermatitis10.1DNAJC13, SLC6A3
19hypotrichosis 710.1PARK2, SNCA
20myoclonic encephalopathy of infants10.1SLC1A2, SNCA
21erythematosquamous dermatosis10.1LRRK2, SLC6A3, SNCA
22ovarian mucinous cystadenocarcinoma10.1SLC1A2, SLC6A3, SNCA
23cervical dystonia10.0
24cervicitis10.0
25adult brain stem glioma10.0HS1BP3, SLC6A3, SNCA
26parkinson disease 1010.0LRRK2, PARK2, SNCA
27epilepsy, progressive myoclonic 1b10.0LRRK2, PARK2, SNCA
28phka2-related phosphorylase kinase deficiency10.0LRRK2, PARK2, SNCA
29ataxia10.0
30mast syndrome10.0LRRK2, PARK2, SNCA
31perry syndrome10.0SLC6A3, SNCA
32tinea unguium10.0FUS, PARK2, SNCA
33angelman syndrome due to imprinting defect in 15q11-q1310.0DNAJC13, LRRK2, SNCA
34multiple system atrophy9.9
35restless legs syndrome9.9
36dementia9.9
37neuronitis9.9
38sexual disorder9.9DRD3, FMR1, SLC6A3
39sarcoma9.8
40cerebritis9.8
41pick disease9.8FUS, LRRK2, PARK2, SNCA
42meier-gorlin syndrome 59.7LRRK2, PARK2, SLC6A3, SNCA
43parkinson disease 19.7LRRK2, PARK2, SLC6A3, SNCA
44adrenal gland pheochromocytoma9.7LRRK2, PARK2, SLC6A3, SNCA
45polycystic kidney disease 29.7LRRK2, PARK2, SLC6A3, SNCA
46avoidant personality disorder9.7DRD3, FMR1, SLC6A3, SNCA
47cerebellar ataxia9.6
48alzheimer disease9.6
49obsessive-compulsive disorder9.6
50hereditary ataxia9.6

Graphical network of the top 20 diseases related to Essential Tremor:



Diseases related to essential tremor

Symptoms for Essential Tremor

About this section

Symptoms by clinical synopsis from OMIM:

190300

Clinical features from OMIM:

190300

Human phenotypes related to Essential Tremor:

 63
id Description HPO Frequency HPO Source Accession
1 dysarthria63 HP:0001260
2 postural tremor63 HP:0002174
3 hand tremor63 HP:0002378

UMLS symptoms related to Essential Tremor:


essential and other specified forms of tremor, myoclonus, tremor, senile tremor, asterixis, action tremor, static tremor, tremor, neonatal, head titubation, physiological tremor, tremor nec in icd9cm_2014, orthostatic tremor, hyperexplexia

Drugs & Therapeutics for Essential Tremor

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Drugs for Essential Tremor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 165)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DopamineapprovedPhase 4, Phase 3375951-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
2
Pregabalinapproved, illicit, investigationalPhase 4355148553-50-85486971
Synonyms:
(3S)-3-(aminomethyl)-5-methylhexanoic acid
(R-)-3-isobutyl GABA
(S)-3-(Aminomethyl)-5-methylhexanoic acid
(S)-3-Isobutyl gaba
(S+)-3-isobutyl GABA
121GE001
148553-50-8
3-Isobutyl gaba
3-isobutyl GABA
AC-1158
AC1NUP03
AKOS005145504
C080245
C8H17NO2
CHEBI:236161
CHEMBL1059
CI 1008
CI-1008
CID5486971
 
D02716
DB00230
FT-0080911
HSDB 7530
LS-75191
Lyrica
Lyrica (TN)
MolPort-000-861-733
PD 144723
PD-144723
Pregabalin
Pregabalin (JAN/USAN/INN)
Pregabalin [USAN]
Pregablin
S-(+)-3-isobutylgaba
S1731_Selleck
SBB062901
TL8001062
TOS-BB-0910
UNII-55JG375S6M
3
AcetylcholineapprovedPhase 4, Phase 3, Phase 277651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
4
Memantineapproved, investigationalPhase 417619982-08-24054
Synonyms:
1,3-Dimethyl-5-adamantanamine
1-Amino-3,5-dimethyladamantane
19982-08-2
3,5-Dimethyl-1-adamantanamine
3,5-Dimethyl-1-adamantylamine
3,5-Dimethyl-1-aminoadamantane
3,5-Dimethyladamantan-1-ylamine
3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine
3,5-dimethyladamantan-1-amine
3,5-dimethyltricyclo[3.3.1.1~3,7~]decan-1-amine
41100-52-1 (Hydrochloride)
51052-62-1
AB00053600
AC1L1HB7
AKOS000113995
BBL000737
BPBio1_001117
BPBio1_001270
BSPBio_001015
Biomol-NT_000209
C13736
CBMicro_020348
CHEBI:152523
CHEMBL807
CID4054
D08174
DB01043
DMAA
DivK1c_000068
EU-0053634
Ebixa
Exiba
Exiba (TN)
HMS500D10
HSDB 7327
IDI1_000068
KBio1_000068
KBio2_001087
KBio2_003655
 
KBio2_006223
KBio3_001926
KBioGR_001543
KBioSS_001087
LS-157051
Lopac0_000861
Memantin
Memantina
Memantina [INN-Spanish]
Memantine
Memantine (INN)
Memantine HCL
Memantine Hydrochloride
Memantine [INN:BAN]
Memantine [INN]
Memantinum
Memantinum [INN-Latin]
MolPort-002-041-858
NCGC00015705-05
NCGC00024782-02
NCGC00024782-03
NINDS_000068
Namenda
Oprea1_480562
Prestwick0_000978
Prestwick1_000978
Prestwick2_000978
Prestwick3_000978
SPBio_001456
SPBio_002926
ST057652
STK520682
Spectrum2_001408
Spectrum3_000923
Spectrum4_001022
Spectrum5_001355
Spectrum_000607
UNII-W8O17SJF3T
ZERO/006024
memantine
5
Propranololapproved, investigationalPhase 4216525-66-64946
Synonyms:
(+-)-Propranolol
(1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol
(R)-(+)-propranolol
(S)-(-)-PROPRANOLOL
1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane
1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol
1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol
1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol
1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol
1-Isopropylamino-3-(1-naphthyloxy)-2-propanol
1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol
1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
13013-17-7
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI)
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI)
3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol
4199-09-1
4199-10-4
525-66-6
AB00053537
AC1L1JA4
AC1Q1QBV
AC1Q1QC0
AKOS000588816
AY 64043
AY-20694
Anaprilin
Anapriline
Angilol
Apsolol
Avlocardyl
BPBio1_001040
BRD-A10070317-003-06-9
BSPBio_000944
BSPBio_002682
Bedranol
Beprane
Berkolol
Beta Neg
Beta-Neg
Beta-Propranolol
Beta-Tablinen
Beta-Timelets
Betachron
Betadren
Betalong
Bio-0732
Bio1_000367
Bio1_000856
Bio1_001345
C07407
C16H21NO2
CBDivE_006180
CCRIS 3082
CHEBI:8499
CHEMBL27
CID4946
Cardinol
Caridolol
Corpendol
D,L-Propranolol
D08443
DB00571
DL-Propranolol hydrochloride
Deralin
DivK1c_000023
Dl-Propranolol Hydrochloride
Dociton
Duranol
EINECS 208-378-0
EINECS 235-867-6
Efektolol
Elbrol
Etalong
Euprovasin
Frekven
HMS2090L21
Herzbase
ICI 45520
IDI1_000023
INDERIDE-40/25
INDERIDE-80/25
Ikopal
Inderal
Inderal La
Inderal hydrochloride
Inderalici
Inderex
Inderide
Inderol
Indobloc
InnoPranXL
 
Innopran XL
Intermigran
KBio1_000023
KBio2_002515
KBio2_005083
KBio2_007651
KBio3_001766
KBio3_001902
KBio3_002993
KBioGR_001347
KBioGR_001684
KBioGR_002515
KBioSS_002523
Kemi
Kemi S
L000679
LS-122410
LS-184129
Lopac0_000896
Migrastat
MolPort-001-794-623
NCGC00015798-07
NCGC00024690-02
NCGC00024690-03
NINDS_000023
NSC91523
Naprilin
Obsidan
Obzidan
Oposim
Oprea1_304193
PDSP1_000767
PDSP1_001607
PDSP1_001608
PDSP2_000755
PDSP2_001591
PDSP2_001592
Prano-Puren
Pranolol
Prestwick0_000952
Prestwick1_000952
Prestwick2_000952
Prestwick3_000952
Pronovan
Propanalol
Propanix
Propanolol
Propanolol [INN-Spanish]
Prophylux
Propranalol
Propranolol
Propranolol (INN)
Propranolol (TN)
Propranolol Hcl
Propranolol Hcl Intensol
Propranolol Hydrochloride
Propranolol [INN:BAN]
Propranololo
Propranololo [DCIT]
Propranololum
Propranololum [INN-Latin]
Propranur
Proprasylyt
Pylapron
R,S-Propranolol Hydrochloride
Racemic propranolol
Rapynogen
Reducor
Reducor Line
Reducor line
SPBio_001361
SPBio_001658
SPBio_003093
STK735510
Sagittol
Sawatal
Servanolol
Sloprolol
Spectrum2_001301
Spectrum2_001699
Spectrum3_000883
Spectrum3_001071
Spectrum4_000974
Spectrum4_001222
Spectrum5_000751
Sumial
Tesnol
UNII-9Y8NXQ24VQ
b-Propranolol
beta-Propranolol
cMAP_000071
etalong
propranolol
propranololo
β-Propranolol
6Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 2, Phase 122776
7Central Nervous System DepressantsPhase 4, Phase 3, Phase 2, Phase 112806
8Dopamine AgentsPhase 4, Phase 33759
9Neurotransmitter AgentsPhase 4, Phase 3, Phase 2, Phase 117734
10Antiparkinson AgentsPhase 4, Phase 31527
11Adrenergic AntagonistsPhase 41535
12Adrenergic beta-AntagonistsPhase 41154
13Anti-Arrhythmia AgentsPhase 4, Phase 12969
14Vasodilator AgentsPhase 43438
15Adrenergic AgentsPhase 4, Phase 3, Phase 2, Phase 15140
16Botulinum ToxinsPhase 4, Phase 3, Phase 2669
17Antihypertensive AgentsPhase 4, Phase 14095
18Pharmaceutical SolutionsPhase 4, Phase 2, Phase 17793
19Cholinergic AgentsPhase 4, Phase 3, Phase 2, Phase 13846
20Anti-Anxiety AgentsPhase 4, Phase 11816
21AnalgesicsPhase 4, Phase 2, Phase 311287
22Excitatory Amino Acid AntagonistsPhase 41282
23Excitatory Amino AcidsPhase 41297
24Tranquilizing AgentsPhase 4, Phase 14164
25AnticonvulsantsPhase 4, Phase 3, Phase 2, Phase 12620
26Psychotropic DrugsPhase 4, Phase 16279
27Calcium, DietaryPhase 4, Phase 25525
28calcium channel blockersPhase 41940
29
IodinePhase 45467553-56-2807
Synonyms:
I2
Iode
Iodine-molecule
 
Iodio
Iodum
Jod
Jood
Tincture iodine
30cadexomer iodinePhase 4514
31CalamusNutraceuticalPhase 4419
32
Cocaineapproved, illicitPhase 350150-36-25760, 446220
Synonyms:
(-)-Cocaine
(-)-Cocaine base
(1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate
(1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl benzoate
(R)-Cocaine
(−)-cocaine
1-Cocaine
1i7z
1q72
2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylate benzoate (ester)
2-beta-Carbomethoxy-3-beta-benzoxytropane
2-beta-Tropanecarboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate (ester)
2beta-Carbomethoxy-3beta-benzoxytropane
3-Tropanylbenzoate-2-carboxylic acid methyl ester
3beta-Hydroxy-2beta-tropanecarboxylic acid methyl ester benzoate (ester)
50-36-2
53-21-4 (hydrochloride)
610089_ALDRICH
610089_FLUKA
AC-16037
AC-20208
AC1L1EK2
AC1L1L2T
AC1L3U2D
AC1L9JBL
Allococaine
Allopseudococaine
Badrock
Bazooka
Benzoylethylecgonine
Benzoylmethylecgonine
Bernice
Bernice [Street Name]
Bernies
Beta-Cocain
Blast
Blizzard
Blow
Blow [Street Name]
Bouncing Powder
Bump
Burese
C" Carrie
C01416
C8912_SIGMA
CHEBI:27958
CID11779748
CID2826
CID446220
CID5760
COC
CPD-9776
Cabello
Candy
Carrie
Caviar
Cecil
Cecil [Street Name]
Charlie
Chicken Scratch
Cholly
Coca
Cocain
Cocaina
Cocaine
Cocaine (TN)
Cocaine (USP)
Cocaine Free Base
Cocaine [BAN]
Cocaine free base
Cocaine solution
Cocaine-M
Cocainum
Cocktail
Coke
Cola
Corine
Crack
Crack cocaine
D-pseudococaine
D00110
DB00907
DEA No. 9041
Dama Blanca
Dama blanca
Delcaine
Depsococaine
Dextrocaine
DivK1c_000975
Dust
EINECS 200-032-7
Ecgonine methyl ester benzoate
Ecgonine methyl ester benzoate solution
Ecgonine, methyl ester, benzoate (ester)
 
Eritroxilina
Erytroxylin
Flake
Flake [Street Name]
Flex
Florida Snow
Foo Foo
Freeze
G-Rock
Girl
Girl [Street Name]
Gold Dust
Gold dust
Gold dust [Street Name]
Goofball
Green Gold
Green gold
HSDB 6469
Happy Dust
Happy Powder
Happy Trails
Happy dust
Happy dust [Street Name]
Happy powder
Happy trails
Heaven
Hell
IDI1_000975
Isocaine
Isococain
Isococaine
Jam
KBio1_000975
Kibbles N' Bits
Kibbles n' Bits
Kokain
Kokan
Kokayeen
L-Cocain
L-Cocaine
L000836
LS-157759
Lady
Lady [Street Name]
Leaf
MLS002320697
Methyl 3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Methyl 3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester)
Methyl Benzoylecgonine
Methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Methyl benzoylecgonine
MolPort-002-535-520
MolPort-003-937-722
Moonrocks
NCGC00159467-02
NINDS_000975
Neurocaine
Nose candy
Pimp's Drug
Pimp's drug
Prime Time
Pseudoallococaine
Pseudococaine
Rock
Rock [Street Name]
SMR001338843
STOCK1N-68258
Sleighride
Snort
Snow
Snow (birds)
Star Dust
Star dust
Star-Spangled Powder
Star-spangled powder
Sugar
Sweet Stuff
Toke
Toot
Toot [Street Name]
Trails
UNII-I5Y540LHVR
White girl or lady
Yeyo
Zip
[1R-(Exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester
beta-Cocain
cocaine
cocainum
d-Pseudococaine
l-Cocain
methyl (1S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
methyl (3S,4R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
methyl 3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
nchembio.284-comp4
33
OxymetazolineapprovedPhase 3, Phase 14401491-59-44636
Synonyms:
1491-59-4
2-(4-Tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline
2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline
3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethyl-6-tert-butyl-phenol
3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol
3-[(4,5-dihydro-1H-Imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol
6-Tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol
6-t-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol
6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol
6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol
AC-6370
AC1L1IM1
Afrin Cherry 12 Hour Nasal Spray
Afrin Extra Moisturizing 12 Hour Nasal Spray
Afrin Original 12 Hour Nasal Spray
Afrin Original 12 Hour Nose Drops
Afrin Original 12 Hour Pump Mist
Afrin Sinus 12 Hour Nasal Spray
BPBio1_000295
BPBio1_000419
BRD-K16195444-001-01-7
BRN 0886303
BSPBio_000267
BSPBio_002145
Biomol-NT_000161
C07363
CAS-151615
CHEBI:142520
CHEMBL762
CID4636
D010109
D08322
DB00935
DivK1c_000567
Dristan Long Lasting Mentholated Nasal Spray
Dristan Long Lasting Nasal Mist
Drixoral Nasal Solution
Duramist Plus Up To 12 Hour Nasal Decongestant Spray
EINECS 216-079-1
FT-0082560
Genasal Nasal Spray Up to 12 Hour Relief
H 990
HMS2089G03
HSDB 3143
Hazol
IDI1_000567
Iliadin
KBio1_000567
KBio2_001531
KBio2_004099
KBio2_006667
KBio3_001645
KBioGR_000908
KBioSS_001531
L000459
LS-104146
 
Lopac-O-2378
Lopac0_000903
MolPort-002-538-313
NCGC00015766-01
NCGC00015766-02
NCGC00015766-03
NCGC00015766-10
NCGC00022345-02
NCGC00022345-04
NCGC00022345-05
NCGC00022345-06
NINDS_000567
Nafrine
Nasal Relief 12 Hour Nasal Spray
Navasin
Navisin
Neo-Synephrine 12 Hour Spray
Nezeril
Nostrilla 12 Hour Nasal Decongestant
Operil (TN)
Oximetazolina
Oximetazolina [INN-Spanish]
Oximetazolinum
Oxylazine
Oxymetazolina
Oxymetazoline (INN)
Oxymetazoline [INN:BAN]
Oxymetazoline hydrochloride crystalline
Oxymetazolinum
Oxymetazolinum [INN-Latin]
Oxymethazoline
Oxymetozoline
Phenol, 3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethyl- (9CI)
Phenol, 6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethyl- (7CI,8CI)
Prestwick0_000224
Prestwick1_000224
Prestwick2_000224
Prestwick3_000224
Rhinofrenol
Rhinolitan
SPBio_001095
SPBio_002188
Sinerol
Spectrum2_000998
Spectrum3_000533
Spectrum4_000464
Spectrum5_001114
Spectrum_001051
Tocris-1142
UNII-8VLN5B44ZY
Vicks Sinex 12 Hour Nasal Spray
Vicks Sinex 12 Hour Ultra Fine Mist for Sinus Relief
Visine L.R
Visine L.R.
nchembio705-11
oxymeta zoline
oxymetazoline
oxymetazoline hydrochloride crystalline
34
TopiramateapprovedPhase 324797240-79-45284627
Synonyms:
-D-fructopyranose deriv.
.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI)
2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Di- O -isopropylidene-(beta)-D-fructopyranose sulfamate
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, .beta.
97240-79-4
AKOS000424547
BIDD:GT0854
BIDD:PXR0127
BRN 5988957
BSPBio_002306
C052342
C07502
C12H21NO8S
CBChromo1_000352
CHEBI:129573
CHEMBL220492
CID5284627
CPD000466325
Cilag brand of topiramate
D00537
DB00273
Epitoma
Epitomax
HMS1922H06
HMS2051L09
HMS2093D20
HSDB 7531
Janssen brand of topiramate
KS-1122
KW-6485
LS-187392
LS-69764
MLS000759431
MLS001424070
McN 4853
McN-4853
MolPort-001-615-062
MolPort-002-885-869
NCGC00178714-01
 
Ortho brand of topiramate
RWJ 17021
RWJ-17021
RWJ-17021-000
S1438_Selleck
SAM001246601
SMR000466325
SPBio_000995
SPECTRUM1505801
STOCK1N-71037
Spectrum2_001128
T0575_SIGMA
TL8006021
TOR
TPM
Tipiramate
Tipiramate [French]
Tipiramato
Tipiramato [Spanish]
Topamac
Topamax
Topamax (TN)
Topamax Sprinkle
Topamax, Topiramate
Topimax
Topina
Topiramate
Topiramate (JAN/USAN/INN)
Topiramate (TPM)
Topiramate / Placebo
Topiramate [USAN:BAN:INN]
Topiramato
Topiramato [INN-Spanish]
Topiramatum
Topiramatum [INN-Latin]
Topiramic acid
Topomax
UNII-0H73WJJ391
USL-255
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate
topiramate
topiramate tablet
topiramatum [Latin]
35
PhenylephrineapprovedPhase 3, Phase 144059-42-76041
Synonyms:
(-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol
(-)-m-Hydroxy-α-(methylaminomethyl)benzyl alcohol
(R)-2-Hydroxy-2-(3-hydroxyphenyl)-N-methylethylamine
(R)-3-Hydroxy-alpha-((methylamino)methyl)benzenemethanol
1416-03-1
3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol
59-42-7
61-76-7 (hydrochloride)
AC1L1LO9
AC1Q40UF
AI3-02402
AK-Dilate
AK-Nefrin
Adrianol
Ah-Chew
Ak-Dilate
Ak-Nefrin
Ak-dilate
Ak-nefrin
Alcon Efrin
Alcon efrin
Alconefrin Nasal Drops 12
Alconefrin Nasal Drops 25
Alconefrin Nasal Drops 50
Alconefrin Nasal Spray 25
BIDD:GT0157
BSPBio_002420
Benzenemethanol, 3-hydroxy-alpha-((methylamino)methyl)-, (R)- (9CI)
Biomydrin
C07441
CCRIS 8464
CHEBI:8093
CHEMBL1215
CID6041
Cyclomydril
D08365
DB00388
Dilatair
Dimetane
Dionephrine
DivK1c_000597
Doktors
Duration
EINECS 200-424-8
EINECS 215-810-1
Fenilefrina
Fenilefrina [INN-Spanish]
HSDB 3383
I-Phrine
IDI1_000597
Isophrim
Isophrin
Isopto Frin
KBio1_000597
KBio2_001581
KBio2_004149
KBio2_006717
KBio3_001640
KBioGR_001313
KBioSS_001581
L-Phenylephedrine
L-Phenylephrine
LS-43027
Lopac-P-6126
Lopac0_000920
M-Methylaminoethanolphenol
M-Oxedrine
M-Sympathol
M-Sympatol
M-Synephrine
 
Mesaton
Mesatone
Mesatonum
Metaoxedrin
Metaoxedrine
Metaoxedrinum
Metasympatol
Metasynephrine
Metsatonum
Mezaton
Minims Phenylephrine
MolPort-001-792-191
Mydfrin
NCGC00015825-01
NCGC00015825-02
NCGC00024257-03
NCGC00024257-05
NCGC00024257-06
NINDS_000597
Neo-Synephrine
Neo-Synephrine Nasal Drops
Neo-Synephrine Nasal Jelly
Neo-Synephrine Nasal Spray
Neo-Synephrine Pediatric Nasal Drops
Neofrin
Neophryn
Neosynephrine
Nostril
Nostril Spray Pump
Nostril Spray Pump Mild
Ocu-Phrin Sterile Eye Drops
Ocu-Phrin Sterile Ophthalmic Solution
Ocugestrin
P0395
PDSP1_001108
PDSP2_001092
Phenoptic
Phenylephrine
Phenylephrine (INN)
Phenylephrine Minims
Phenylephrine Minims (TN)
Phenylephrine [INN:BAN]
Phenylephrinum
Phenylephrinum [INN-Latin]
Prefrin
Prefrin Liquifilm
Pyracort D
R(-)-Mezaton
R(-)-Phenylephrine
Relief Eye Drops for Red Eyes
Rhinall
SPBio_001280
Spectrum2_001280
Spectrum3_000770
Spectrum4_000967
Spectrum5_001411
Spectrum_001101
Spersaphrine
Tannins, compds. with (R)-3-hydroxy-alpha-((methylamino)methyl)benzenemethanol
UNII-1WS297W6MV
Vicks Sinex
Visadron
l-(3-Hydroxyphenyl)-N-methylethanolamine
l-1-(m-Hydroxyphenyl)-2-methylaminoethanol
l-alpha-Hydroxy-beta-methylamino-3-hydroxy-L-ethylbenzene
l-m-Hydroxy-alpha-((methylamino)methyl)benzyl alcohol
m-Methylaminoethanolphenol
m-Oxedrine
m-Sympathol
m-Sympatol
m-Synephrine
phenylephrine
36
Pramipexoleapproved, investigationalPhase 3139104632-26-059868, 119570
Synonyms:
(-)-Pramipexole
(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
(6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
(6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole
(S)-N  6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
104632-26-0
111GE001
2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole
2-amino-6-propylaminotetrahydrobenzothiazole
AC1L3P1T
BIDD:GT0250
C10H17N3S
CHEBI:8356
CHEMBL301265
CID119570
CPD000449298
D05575
DivK1c_006916
Furfuryl Acetate
HMS2051A21
HMS2090C15
KBio1_001860
KBio2_002340
KBio2_004908
 
KBio2_007476
KBioSS_002343
LS-40722
MLS000758250
MLS001423952
Mirapex
MolPort-003-849-957
NCGC00167441-01
Pramipexol
Pramipexol [Spanish]
Pramipexole
Pramipexole (USAN/INN)
Pramipexole 2HCl Monohydrate
Pramipexole [USAN:INN]
Pramipexole hydrochloride
Pramipexolum
Pramipexolum [Latin]
SAM001247006
SBB070477
SMR000449298
SND-919
SUD919CL2Y
SpecPlus_000820
Spectrum5_001453
Spectrum_001838
U-98528E
pramipexole
37Dopamine Uptake InhibitorsPhase 31305
38Vasoconstrictor AgentsPhase 32027
39AnestheticsPhase 3, Phase 2, Phase 19001
40Anesthetics, LocalPhase 33272
41Neurotransmitter Uptake InhibitorsPhase 33464
42
Salmeterol xinafoatePhase 3, Phase 2, Phase 135094749-08-356801
Synonyms:
(+-)-4-Hydroxy-alpha(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-m-xylene-alpha,alpha'-diol 1-hydroxy-2-naphthoate (salt)
(+/-) 4-Hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]m-ethyl]-1,3-benzenedimethanol xinafoate
1,3-Benzenedimethanol, 4-hydroxy-alpha(sup 1)-(((6-(4-phenylbutoxy)hexyl)amino)methyl)-, (+-)-, 1-hydroxy-2-naphthalenecarboxylate (salt)
1-hydroxynaphthalene-2-carboxylic acid
2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
89365-50-4 (Parent)
94749-08-3
AC1L1LPS
Arial
Asmerole
Beglan
Betamican
Bio-0096
C25H37NO4.C11H8O3
CHEMBL1082607
CID56801
D00687
Dilamax
EU-0101100
GR 33343 G
GR 33343X xinafoate
 
GR-33343 G
Inaspir
LS-94516
MLS001332577
MLS001332578
MolPort-003-850-218
NCGC00094372-01
NCGC00094372-02
NCGC00094372-03
NCGC00094372-04
S5068_SIGMA
SMR000875207
Salmetedur
Salmeterol 1-hydroxy-2-naphthoate
Salmeterol xinafoate (JAN/USAN)
Salmeterol xinafoate [USAN]
Serevent (TN)
Serevent Inhaler and Disks
Serevent diskus
UNII-6EW8Q962A5
Ultrabeta
salmeterol xinafoate
43ParasympatholyticsPhase 3, Phase 2, Phase 11050
44Respiratory System AgentsPhase 3, Phase 2, Phase 14818
45Tiotropium BromidePhase 3, Phase 2, Phase 1324136310-93-5
46Botulinum Toxins, Type APhase 3, Phase 2630
47Hypnotics and SedativesPhase 2, Phase 3, Phase 12485
48onabotulinumtoxinAPhase 3, Phase 2626
49incobotulinumtoxinAPhase 3, Phase 2635
50abobotulinumtoxinAPhase 3, Phase 2626

Interventional clinical trials:

(show top 50)    (show all 197)
idNameStatusNCT IDPhase
1Validation of DaTscan for Detection of Parkinson Disease Related DisordersUnknown statusNCT02138682Phase 4
2A Pilot Clinical Trial Of Memantine for Essential TremorCompletedNCT00439699Phase 4
3Pregabalin in the Treatment of Essential TremorCompletedNCT00646451Phase 4
4Pregabalin (Lyrica) for the Treatment of Essential TremorCompletedNCT00584376Phase 4
5Propranolol and Botulinum Toxin for Essential Vocal TremorCompletedNCT02111369Phase 4
6RECHARGE Sub-Study to the Implantable Systems Performance Registry (ISPR)CompletedNCT00998660Phase 4
7A Study to Assess Changes in Clinical Management After DaTSCAN Imaging of Subjects With Clinically Uncertain Parkinsonism or an Illness With Similar SymptomsCompletedNCT00382967Phase 4
8Atlas Predicted DBS Settings in Essential TremorEnrolling by invitationNCT02678429Phase 4
9DaTSCAN Imaging in Aging and Neurodegenerative DiseaseEnrolling by invitationNCT01453127Phase 4
10Two Separate But Identical Studies Evaluating the Safety and Efficacy of ALTROPANE® in the Use of SPECT Imaging for Upper Extremity TremorUnknown statusNCT00724906Phase 3
11Novel Therapies for Essential TremorCompletedNCT00018564Phase 3
12A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause.CompletedNCT00236496Phase 3
13Efficacy and Safety of F-18 FPCIT PET in Parkinson's Disease and Essential Tremor PatientsCompletedNCT00468078Phase 3
14Tiotropium and Salmeterol PK Study in COPD PatientsCompletedNCT00673478Phase 3
15Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential TremorRecruitingNCT02555982Phase 3
16Long-term Effect of Low Frequency Stimulation on Aspiration and Freezing of Gait in PD With STN DBSRecruitingNCT02549859Phase 2, Phase 3
17Efficacy of Pramipexole Extended Release in the Treatment of Essential TremorNot yet recruitingNCT01441284Phase 3
18Pre-lemniscal Radiation Deep Brain Stimulation for ETTerminatedNCT00634478Phase 2, Phase 3
19Dexmedetomidine Effects on Microelectrode Recording in Deep Brain StimulationWithdrawnNCT00608231Phase 2, Phase 3
20A Safety/Efficacy Trial of Zonisamide for Essential TremorCompletedNCT00223743Phase 2
21Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential TremorCompletedNCT00598078Phase 2
22A Pilot Efficacy and Safety Study of ST101 in Essential TremorCompletedNCT01332695Phase 2
23A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential TremorCompletedNCT00524056Phase 2
24Octanol to Treat Essential TremorCompletedNCT00080366Phase 2
25Efficacy of Levetiracetam in Essential TremorCompletedNCT00620165Phase 1, Phase 2
26Double-Blind, Placebo Controlled Pilot Study of Octanoic Acid in Essential TremorCompletedNCT00848172Phase 1, Phase 2
27Evaluate SAGE-547 in Patients With Essential TremorCompletedNCT02277106Phase 2
28Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential TremorCompletedNCT00102596Phase 2
29Botulinum Toxin A to Treat Arm TremorCompletedNCT02207946Phase 2
30Effect of Alcohol on TremorsCompletedNCT00001925Phase 2
31Pharmacokinetics and Safety Comparison of Tiotropium Inhalation Powder Administered as the Bromide Salt From Hard Polyethylene Capsule Via the HandiHaler® 2 and Spiriva® HandiHaler® in Patients With Chronic Obstructive Pulmonary Disease (COPD)CompletedNCT02242266Phase 2
32Efficacy, Pharmacokinetics and Safety Comparison of Salmeterol Inhalation Powder Administered Via the HandiHaler® 2 and Serevent® Diskus® in Patients With Chronic Obstructive Pulmonary Disease (COPD)CompletedNCT02242227Phase 2
33Salmeterol Inhalation Powder Administered as the Xinafoate Salt From Hard Polyethylene Capsules Via the HandiHaler® 2, and Serevent® Diskus® in Patients With Chronic Obstructive Pulmonary Disease (COPD)CompletedNCT02238106Phase 2
34Botulinum Toxin Type A for Injection of Bilateral Upper Extremity Tremor in Patients With Essential Tremor Using Kinematic AssessmentRecruitingNCT02551848Phase 2
35A Study to Evaluate SAGE-217 in Subjects With Essential TremorRecruitingNCT02978781Phase 2
36Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres?RecruitingNCT02960243Phase 1, Phase 2
37Effects of Octanoic Acid for Treatment of Essential Voice TremorRecruitingNCT01864525Phase 1, Phase 2
38Randomised Crossover Trial of Deep Brain Stimulation of Differential Posterior Subthalamic Area Regions in Parkinson's Disease and TremorRecruitingNCT01945567Phase 2
39Deep Brain Frameless Radiosurgery for Drug Resistant Invalidating Tremor. Dose Escalation Pilot StudyRecruitingNCT02585583Phase 2
40An Efficacy/Safety Study of Perampanel for Reducing Essential TremorActive, not recruitingNCT02668146Phase 2
41Use of Kinematic Assessment of Hand Tremor Pre- and Post- Treatment With Botulinum Toxin Type A in Essential Tremor and Parkinson DiseaseEnrolling by invitationNCT02427646Phase 2
42A Study of T2000 in Essential TremorTerminatedNCT00321087Phase 2
43T2000 in Essential Tremor - Open Label ContinuationTerminatedNCT00655278Phase 2
44Octanoic Acid for Essential TremorCompletedNCT01468948Phase 1
451-Octanol to Treat Essential TremorCompletedNCT00016679Phase 1
461-Octanol to Treat Essential TremorCompletedNCT00001986Phase 1
47ExAblate Transcranial MR Guided Focused Ultrasound in the Treatment of Essential TremorCompletedNCT02037217Phase 1
48ExAblate Transcranial MR Guided Focused Ultrasound in the Treatment of Essential TremorCompletedNCT01304758Phase 1
49Magnetic Resonance (MR) Guided Functional Ultrasound-Neurosurgery for Movement DisordersCompletedNCT01698450Phase 1
50Pharmacokinetics of Bisacodyl or Sodium Picosulfate Administered Orally in Healthy Lactating FemalesCompletedNCT02211911Phase 1

Search NIH Clinical Center for Essential Tremor

Inferred drug relations via UMLS67/NDF-RT45:


Cochrane evidence based reviews: essential tremor

Genetic Tests for Essential Tremor

About this section

Genetic tests related to Essential Tremor:

id Genetic test Affiliating Genes
1 Hereditary Essential Tremor 126 24 DRD3
2 Essential Tremor26

Anatomical Context for Essential Tremor

About this section

MalaCards organs/tissues related to Essential Tremor:

35
Brain, Cerebellum, Cortex, Testes, Thalamus, Liver, Eye

Animal Models for Essential Tremor or affiliated genes

About this section

MGI Mouse Phenotypes related to Essential Tremor:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8FMR1, HTRA2, LRRK2, PARK2, SLC6A3, SNCA
2MP:00053847.9FMR1, HTRA2, LRRK2, PARK2, SLC1A2, SLC6A3
3MP:00053867.7DRD3, FMR1, HTRA2, LRRK2, PARK2, SLC1A2
4MP:00036316.9DRD3, FMR1, HTRA2, LRRK2, PARK2, SLC1A2

Publications for Essential Tremor

About this section

Articles related to Essential Tremor:

(show top 50)    (show all 674)
idTitleAuthorsYear
1
Emotion modulation of the startle reflex in essential tremor: Blunted reactivity to unpleasant and pleasant pictures. (27887893)
2017
2
Essential tremor linked TENM4 mutation found in healthy Chinese individuals. (27569844)
2016
3
A Trial of Focused Ultrasound Thalamotomy for Essential Tremor. (27959760)
2016
4
Essential tremor: Update of therapeutic strategies (medical treatment and gamma knife thalamotomy). (27561439)
2016
5
Agnosia for head tremor in essential tremor: prevalence and clinical correlates. (26877883)
2016
6
Genetic analysis of FMR1 repeat expansion in essential tremor. (25796179)
2015
7
The potential of LINGO-1 as a therapeutic target for essential tremor. (25862159)
2015
8
Temporal fluctuations of tremor signals from inertial sensor: a preliminary study in differentiating Parkinson's disease from essential tremor. (26530430)
2015
9
Severity stages in essential tremor: a long-term retrospective study using the glass scale. (25793146)
2015
10
Non-steroidal anti-inflammatory drug use and essential tremor. (25376662)
2014
11
Re-thinking the biology of essential tremor: from models to morphology. (24262197)
2014
12
Functional Anatomy of Essential Tremor: Lessons from Neuroimaging. (23620075)
2013
13
Key issues in essential tremor genetics research: Where are we now and how can we move forward? (23450143)
2013
14
Abnormal regional homogeneity in patients with essential tremor revealed by resting-state functional MRI. (23869236)
2013
15
Ocular flutter in essential tremor: clinical course and response to primidone. (24061767)
2013
16
Temporal discrimination in patients with dystonia and tremor and patients with essential tremor. (23243072)
2013
17
Simultaneous thalamic and posterior subthalamic electrode insertion with single deep brain stimulation electrode for essential tremor. (22985104)
2013
18
Neuroanatomical heterogeneity of essential tremor according to propranolol response. (24358327)
2013
19
Cortical control of saccades in Parkinson disease and essential tremor. (22926662)
2013
20
Autonomic function, as self-reported on the SCOPA-autonomic questionnaire, is normal in essential tremor but not in Parkinson's disease. (22771283)
2012
21
Psychiatric disorders in patients with essential tremor. (22658234)
2012
22
Phenocopies in families with essential tremor and restless legs syndrome challenge Mendelian laws. Epigenetics might provide answers. (22521244)
2012
23
High width variability during spiral drawing: further evidence of cerebellar dysfunction in essential tremor. (22230985)
2012
24
The role of event-related potentials in subclinical cognitive dysfunction in essential tremor. (22353988)
2012
25
Treatment of Essential Tremor: Are there Issues We are Overlooking? (22275907)
2011
26
Tremor during movement correlates well with disability in people with essential tremor. (21656852)
2011
27
A diffusion tensor imaging study in essential tremor. (21091815)
2011
28
Action tremor caused by olivary cavernoma in Klippel-TrAcnaunay syndrome mimicking asymmetric essential tremor. (20668889)
2011
29
Marked reduction of tremor in essential tremor after putaminal infarct. (20581413)
2010
30
Long-term results of thalamic deep brain stimulation for essential tremor. (19911883)
2010
31
Genetics of Parkinson disease and essential tremor. (20489616)
2010
32
Successful implantation of a deep brain stimulator for essential tremor in a patient with a preexisting cochlear implant: surgical technique: technical case report. (20489530)
2010
33
Tandem gait performance in essential tremor: clinical correlates and association with midline tremors. (20629168)
2010
34
Clustering of dystonia in some pedigrees with autosomal dominant essential tremor suggests the existence of a distinct subtype of essential tremor. (20670416)
2010
35
Essential tremor with ubiquitinated Purkinje cell intranuclear inclusions. (20107820)
2010
36
Development of an essential tremor embarrassment assessment. (20869901)
2010
37
Gait and balance in essential tremor: variable effects of bilateral thalamic stimulation. (19006189)
2009
38
Prevalence of essential tremor: a door-to-door survey in Sile, Istanbul, Turkey. (18474448)
2009
39
An update on essential tremor. (19515278)
2009
40
Mirror movements in patients with essential tremor. (19795466)
2009
41
Dopamine receptor D3 (DRD3) genotype and allelic variants and risk for essential tremor. (19645064)
2009
42
LINGO1 variant increases risk of familial essential tremor. (19805735)
2009
43
Cerebellar atrophy in essential tremor using an automated segmentation method. (19342539)
2009
44
Motor learning in essential tremor. (19243062)
2009
45
A randomized comparison of thalamic stimulation and lesion on self-paced finger movement in essential tremor. (19591898)
2009
46
Fertility in essential tremor. Data from population-based and clinical sources. (18784418)
2008
47
The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor. (18543121)
2008
48
Olfactory tests in the diagnosis of essential tremor. (18321760)
2008
49
A model predicting optimal parameters for deep brain stimulation in essential tremor. (18791473)
2008
50
Manic-depressive illness associated with Klinefelter's syndrome and essential tremors. (655296)
1978

Variations for Essential Tremor

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Clinvar genetic disease variations for Essential Tremor:

5
id Gene Variation Type Significance SNP ID Assembly Location
1DNAJC13NM_015268.3(DNAJC13): c.2564A> G (p.Asn855Ser)SNVPathogenicrs387907571GRCh37Chr 3, 132196839: 132196839

Expression for genes affiliated with Essential Tremor

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Search GEO for disease gene expression data for Essential Tremor.

Pathways for genes affiliated with Essential Tremor

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GO Terms for genes affiliated with Essential Tremor

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Cellular components related to Essential Tremor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1inclusion bodyGO:001623410.5LRRK2, SNCA
2polysomeGO:00058449.8FMR1, FUS
3presynapseGO:00987939.8FMR1, PARK2, SLC6A3
4postsynapseGO:00987949.7FMR1, LRRK2, SNCA
5growth coneGO:00304269.4FMR1, LRRK2, SNCA
6perikaryonGO:00432049.2FMR1, FUS, LRRK2
7neuron projectionGO:00430058.9FMR1, LRRK2, PARK2, SLC6A3, TENM4
8axonGO:00304248.1FMR1, LRRK2, SLC1A2, SLC6A3, SNCA
9membraneGO:00160207.6DNAJC13, DRD3, FMR1, HTRA2, LRRK2, SLC1A2

Biological processes related to Essential Tremor according to GeneCards Suite gene sharing:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1regulation of synaptic vesicle transportGO:190280310.4LRRK2, PARK2
2cellular response to manganese ionGO:007128710.4LRRK2, PARK2
3dopamine biosynthetic processGO:004241610.3SLC6A3, SNCA
4regulation of neuron deathGO:190121410.3LRRK2, SNCA
5negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayGO:190223610.3LRRK2, PARK2
6excitatory postsynaptic potentialGO:006007910.3LRRK2, SNCA
7regulation of canonical Wnt signaling pathwayGO:006082810.3LRRK2, PARK2
8protein destabilizationGO:003164810.2PARK2, SNCA
9cellular response to dopamineGO:190335110.2LRRK2, PARK2
10regulation of reactive oxygen species metabolic processGO:200037710.2PARK2, SNCA
11protein localization to mitochondrionGO:007058510.2LRRK2, PARK2
12regulation of dopamine metabolic processGO:004205310.1PARK2, SLC6A3
13behavioral response to cocaineGO:004814810.1DRD3, SNCA
14dopamine uptake involved in synaptic transmissionGO:005158310.1PARK2, SLC6A3, SNCA
15positive regulation of proteasomal protein catabolic processGO:190180010.0FMR1, PARK2
16cellular protein catabolic processGO:004425710.0HTRA2, PARK2
17positive regulation of dopamine receptor signaling pathwayGO:006016110.0DRD3, LRRK2
18regulation of mitophagyGO:190314610.0HTRA2, PARK2
19regulation of multicellular organism growthGO:00400149.9DRD3, HTRA2
20negative regulation of protein phosphorylationGO:00019339.8LRRK2, PARK2, SNCA
21prepulse inhibitionGO:00601349.8DRD3, SLC6A3
22cellular response to oxidative stressGO:00345999.8HTRA2, LRRK2, SNCA
23response to cocaineGO:00422209.7DRD3, SLC6A3, SNCA
24regulation of neurotransmitter secretionGO:00469289.7FMR1, PARK2, SNCA
25agingGO:00075689.7HTRA2, SLC6A3, SNCA
26regulation of dopamine secretionGO:00140599.7DRD3, PARK2, SNCA
27mitochondrion organizationGO:00070059.7HTRA2, LRRK2, PARK2
28synaptic transmission, dopaminergicGO:00019639.6DRD3, PARK2, SNCA
29adult locomotory behaviorGO:00083449.6HTRA2, PARK2, SNCA
30regulation of locomotionGO:00400129.6DRD3, LRRK2, SNCA
31dopamine metabolic processGO:00424179.5DRD3, PARK2, SNCA
32negative regulation of neuron deathGO:19012159.4HTRA2, LRRK2, PARK2, SNCA
33locomotory behaviorGO:00076269.2DRD3, PARK2, SLC6A3
34response to drugGO:00424939.0DRD3, SLC1A2, SLC6A3, SNCA

Molecular functions related to Essential Tremor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipase bindingGO:004327410.1PARK2, SNCA
2dynein bindingGO:004550210.0FMR1, SNCA
3dopamine bindingGO:00352409.9DRD3, SLC6A3
4microtubule bindingGO:00080179.5FMR1, LRRK2, SNCA
5identical protein bindingGO:00428028.3FMR1, FUS, LRRK2, PARK2, SNCA

Sources for Essential Tremor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet