MCID: EST002
MIFTS: 36

Estrogen-Receptor Negative Breast Cancer malady

Cancer diseases category

Summaries for Estrogen-Receptor Negative Breast Cancer

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32MalaCards
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MalaCards: Estrogen-Receptor Negative Breast Cancer is related to breast cancer and prostate cancer. An important gene associated with Estrogen-Receptor Negative Breast Cancer is FOXA1 (forkhead box A1). The compounds skf 96365 hydrochloride and biochanin a have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and t cells.

Aliases & Classifications for Estrogen-Receptor Negative Breast Cancer

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Sources:
8Disease Ontology
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

estrogen-receptor negative breast cancer 8


External Ids:

Disease Ontology8 DOID:0060076

Related Diseases for Estrogen-Receptor Negative Breast Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Estrogen-Receptor Negative Breast Cancer family:

Estrogen-Receptor Positive Breast Cancer

Diseases related to Estrogen-Receptor Negative Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer32.0TFF1, CRAT, WNT5A
2prostate cancer30.4FOXA1, PSCA, TFF1, CRAT, CHUK, WNT5A
3estrogen-receptor positive breast cancer10.8
4lymph node cancer10.5
5vascular cancer10.5
6estrogen excess10.3
7colon cancer10.3
8lung cancer10.3
9obesity10.3
10prostatitis10.3
11ovarian cancer10.0TFF1, MSN, ESRRA
12adenocarcinoma10.0FOSL1, PSCA, TFF1, CHUK, WNT5A, MSN
13t-cell leukemia10.0FOSL1, CRAT, CHUK, NT5E
14glioblastoma multiforme10.0CRAT, MDM4
15squamous cell carcinoma10.0FOSL1, TFF1, CRAT, CHUK, WNT5A, MSN
16pancreatic cancer10.0CHUK, TFF1, PSCA
17astrocytoma10.0CRAT

Graphical network of diseases related to Estrogen-Receptor Negative Breast Cancer:



Diseases related to estrogen-receptor negative breast cancer

Clinical Features for Estrogen-Receptor Negative Breast Cancer

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Drugs & Therapeutics for Estrogen-Receptor Negative Breast Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Estrogen-Receptor Negative Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Estrogen-Receptor Negative Breast Cancer

Search NIH Clinical Center for Estrogen-Receptor Negative Breast Cancer

Search CenterWatch for Estrogen-Receptor Negative Breast Cancer

Genetic Tests for Estrogen-Receptor Negative Breast Cancer

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Anatomical Context for Estrogen-Receptor Negative Breast Cancer

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Sources:
32MalaCards
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MalaCards organs/tissues related to Estrogen-Receptor Negative Breast Cancer:

32
Breast, Lymph node, T cells, Testes, Prostate, Skin, Lung, Colon, Brain, Endothelial

Animal Models for Estrogen-Receptor Negative Breast Cancer or affiliated genes

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Publications for Estrogen-Receptor Negative Breast Cancer

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50PubMed
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Articles related to Estrogen-Receptor Negative Breast Cancer:

(show top 50)    (show all 248)
idTitleAuthorsYear
1
17I^-estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1. (23907016)
2013
2
Antineoplastic effects of I+-santalol on estrogen receptor-positive and estrogen receptor-negative breast cancer cells through cell cycle arrest at G2/M phase and induction of apoptosis. (23451128)
2013
3
High expression of class III I^-tubulin predicts good response to neoadjuvant taxane and doxorubicin/cyclophosphamide-based chemotherapy in estrogen receptor-negative breast cancer. (23218766)
2013
4
Metastasis tumor-associated protein 2 enhances metastatic behavior and is associated with poor outcomes in estrogen receptor-negative breast cancer. (24077732)
2013
5
The financial burden of using Oncotype Dx for patients with lymph node-negative and estrogen receptor-positive breast cancer in Australia. (23718901)
2013
6
CpG island methylation profile of estrogen receptor alpha in Iranian females with triple negative or non-triple negative breast cancer: new marker of poor prognosis. (22524805)
2012
7
A new susceptibility locus for estrogen receptor-negative breast cancer. (22228736)
2012
8
Dithiolethiones inhibit NF-I_B activity via covalent modification in human estrogen receptor-negative breast cancer. (22436383)
2012
9
The epigenetic silencing of the estrogen receptor (ER) by hypermethylation of the ESR1 promoter is seen predominantly in triple-negative breast cancers in Indian women. (22362381)
2012
10
Cross-regulation between FOXA1 and ErbB2 signaling in estrogen receptor-negative breast cancer. (22577344)
2012
11
Promoter hypermethylation of estrogen receptor alpha gene is correlated to estrogen receptor negativity in Iranian patients with sporadic breast cancer. (23508069)
2012
12
Synergy between inhibitors of androgen receptor and MEK has therapeutic implications in estrogen receptor-negative breast cancer. (21457548)
2011
13
Value of post-operative reassessment of estrogen receptor I+ expression following neoadjuvant chemotherapy with or without gefitinib for estrogen receptor negative breast cancer. (21516302)
2011
14
Study of Estrogen Receptor and Progesterone Receptor Expression in Breast Ductal Carcinoma In Situ by Immunohistochemical Staining in ER/PgR-Negative Invasive Breast Cancer. (22091428)
2011
15
Parity and lactation in relation to estrogen receptor negative breast cancer in African American women. (21846820)
2011
16
Risk of recurrence and chemotherapy benefit for patients with node-negative, estrogen receptor-positive breast cancer: recurrence score alone and integrated with pathologic and clinical factors. (22010013)
2011
17
Targeting androgen receptor in estrogen receptor-negative breast cancer. (21741601)
2011
18
A feedback loop between androgen receptor and ERK signaling in estrogen receptor-negative breast cancer. (21403841)
2011
19
Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer. (22151962)
2011
20
Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. (20650001)
2010
21
A genome-wide association scan on estrogen receptor-negative breast cancer. (21062454)
2010
22
Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid. (20027631)
2010
23
Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival. (20308648)
2010
24
Selective association of peroxiredoxin 1 with genomic DNA and COX-2 upstream promoter elements in estrogen receptor negative breast cancer cells. (20631257)
2010
25
Retraction for Ford et al., Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells. (21127265)
2010
26
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer. (19762336)
2009
27
Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression. (19385968)
2009
28
Steroid Receptor RNA Activator Protein (SRAP): a potential new prognostic marker for estrogen receptor-positive/node-negative/younger breast cancer patients. (19740422)
2009
29
A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study. (18771580)
2008
30
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. (18974123)
2008
31
Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. (18183590)
2008
32
Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target. (18243688)
2008
33
17HSD 2 may be higher in African-American breast cancer and is associated with estrogen receptor-negative tumors. (17993718)
2007
34
An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer. (17683518)
2007
35
Interleukin-8 modulates growth and invasiveness of estrogen receptor-negative breast cancer cells. (17621625)
2007
36
Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor. (16505096)
2006
37
The antitumor effect of LJ-529, a novel agonist to A3 adenosine receptor, in both estrogen receptor-positive and estrogen receptor-negative human breast cancers. (16546983)
2006
38
Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance. (16145046)
2005
39
Estrogen receptor-negative and human epidermal growth factor receptor 2-negative breast cancer tissue have the highest Ki-67 labeling index and EGFR expression: gene amplification does not contribute to EGFR expression. (16012712)
2005
40
Estrogen receptor alpha binds to peroxisome proliferator-activated receptor response element and negatively interferes with peroxisome proliferator-activated receptor gamma signaling in breast cancer cells. (16144913)
2005
41
Estrogen receptor/progesterone receptor-negative breast cancers of young African-American women have a higher frequency of methylation of multiple genes than those of Caucasian women. (15041725)
2004
42
Induction of antiproliferation and apoptosis in estrogen receptor negative MDA-231 human breast cancer cells by mifepristone and 4-hydroxytamoxifen combination therapy: a role for TGFbeta1. (12851686)
2003
43
A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine. (14620913)
2003
44
Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. (10900013)
2000
45
Adenovirus-mediated delivery of a dominant negative estrogen receptor gene abrogates estrogen-stimulated gene expression and breast cancer cell proliferation. (10379895)
1999
46
A cost-effectiveness analysis of axillary node dissection in postmenopausal women with estrogen receptor-positive breast cancer and clinically negative axillary nodes. (10486611)
1999
47
Differential expression of the MT-1E gene in estrogen-receptor-positive and -negative human breast cancer cell lines. (9422519)
1998
48
Tamoxifen and chemotherapy for lymph node-negative, estrogen receptor-positive breast cancer. (9390536)
1997
49
Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. (8662863)
1996
50
Differential effects of phorbol ester on epidermal growth factor receptors in estrogen receptor-positive and -negative breast cancer cell lines. (2379149)
1990

Genetic Variations for Estrogen-Receptor Negative Breast Cancer

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Expression for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Estrogen-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Estrogen-Receptor Negative Breast Cancer.

Pathways for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Compounds for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources:
59Tocris Bioscience, 44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1skf 96365 hydrochloride5910.7ORAI1, ORAI3, ORAI2
2biochanin a4410.7TFF1, ESRRA
3diethylstilbestrol44 28 1112.7ESRRA, CRAT, TFF1
4estrogen4410.6MSN
5pdtc4410.6FOSL1, CRAT, CHUK
6retinoid4410.6CHUK, CRAT, TFF1, FOSL1
7fatty acid4410.6TFF1, CRAT, CHUK, MSN, ESRRA
812-o-tetradecanoylphorbol 13-acetate4410.5FOSL1, TFF1, CRAT, CHUK
9tamoxifen44 49 28 1113.4TFF1, CRAT, CHUK, ESRRA
10retinoic acid44 2411.4FOSL1, TFF1, CRAT, CHUK, WNT5A, ESRRA
11phorbol4410.4CHUK, CRAT, FOSL1
12hyaluronic acid44 2411.4MSN, CRAT, TFF1
13apigenin44 2811.3TFF1, CHUK
14daidzein4410.1ESRRA, TFF1

GO Terms for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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16Gene Ontology
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Biological processes related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell-cell adhesion mediated by cadherinGO:200004910.4WNT5A, FOXA1

Molecular functions related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein domain specific bindingGO:01990410.4ESRRA, WNT5A, FOXA1

Products for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources for Estrogen-Receptor Negative Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet