MCID: EST002
MIFTS: 36

Estrogen-Receptor Negative Breast Cancer malady

Cancer diseases category

Summaries for Estrogen-Receptor Negative Breast Cancer

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32MalaCards
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MalaCards: Estrogen-Receptor Negative Breast Cancer is related to breast cancer and prostate cancer. An important gene associated with Estrogen-Receptor Negative Breast Cancer is FOXA1 (forkhead box A1). The compounds skf 96365 hydrochloride and biochanin a have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and colon.

Aliases & Classifications for Estrogen-Receptor Negative Breast Cancer

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Sources:
8Disease Ontology
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

estrogen-receptor negative breast cancer 8


External Ids:

Disease Ontology8 DOID:0060076

Related Diseases for Estrogen-Receptor Negative Breast Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Estrogen-Receptor Negative Breast Cancer family:

Estrogen-Receptor Positive Breast Cancer

Diseases related to Estrogen-Receptor Negative Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer32.0TFF1, CRAT, WNT5A
2prostate cancer30.4FOXA1, PSCA, TFF1, CRAT, CHUK, WNT5A
3estrogen-receptor positive breast cancer10.8
4lymph node cancer10.5
5vascular cancer10.5
6estrogen excess10.3
7colon cancer10.3
8lung cancer10.3
9obesity10.3
10prostatitis10.3
11ovarian cancer10.0TFF1, MSN, ESRRA
12adenocarcinoma10.0FOSL1, PSCA, TFF1, CHUK, WNT5A, MSN
13t-cell leukemia10.0FOSL1, CRAT, CHUK, NT5E
14glioblastoma multiforme10.0CRAT, MDM4
15squamous cell carcinoma10.0FOSL1, TFF1, CRAT, CHUK, WNT5A, MSN
16pancreatic cancer10.0CHUK, TFF1, PSCA
17astrocytoma10.0CRAT

Graphical network of diseases related to Estrogen-Receptor Negative Breast Cancer:



Diseases related to estrogen-receptor negative breast cancer

Clinical Features for Estrogen-Receptor Negative Breast Cancer

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Drugs & Therapeutics for Estrogen-Receptor Negative Breast Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Estrogen-Receptor Negative Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Estrogen-Receptor Negative Breast Cancer

Search NIH Clinical Center for Estrogen-Receptor Negative Breast Cancer

Search CenterWatch for Estrogen-Receptor Negative Breast Cancer

Genetic Tests for Estrogen-Receptor Negative Breast Cancer

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Anatomical Context for Estrogen-Receptor Negative Breast Cancer

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Sources:
32MalaCards
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MalaCards organs/tissues related to Estrogen-Receptor Negative Breast Cancer:

32
Breast, Lymph node, Colon, Endothelial, T cells, Testes, Lung, Brain, Skin, Prostate

Animal Models for Estrogen-Receptor Negative Breast Cancer or affiliated genes

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Publications for Estrogen-Receptor Negative Breast Cancer

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50PubMed
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Articles related to Estrogen-Receptor Negative Breast Cancer:

(show top 50)    (show all 248)
idTitleAuthorsYear
1
Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women. (23532538)
2013
2
Syndecan binding protein (SDCBP) is overexpressed in estrogen receptor negative breast cancers, and is a potential promoter for tumor proliferation. (23533663)
2013
3
Does microenvironment contribute to the etiology of estrogen receptor-negative breast cancer? (23325583)
2013
4
KISS1R induces invasiveness of estrogen receptor-negative human mammary epithelial and breast cancer cells. (23525242)
2013
5
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. (23971947)
2013
6
Hydrogen sulfide-releasing aspirin suppresses NF-I_B signaling in estrogen receptor negative breast cancer cells in vitro and in vivo. (22209867)
2012
7
Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer. (22817771)
2012
8
Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer. (22971289)
2012
9
Coffee consumption modifies risk of estrogen-receptor negative breast cancer. (21569535)
2011
10
Impact of the 21-gene recurrence score assay compared with standard clinicopathologic guidelines in adjuvant therapy selection for node-negative, estrogen receptor-positive breast cancer. (21537874)
2011
11
MDM2 amplification is an independent prognostic feature of node-negative, estrogen receptor-positive early-stage breast cancer. (21896991)
2010-2011
12
High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation. (19851860)
2010
13
Association between the 21-gene recurrence score assay and risk of locoregional recurrence in node-negative, estrogen receptor-positive breast cancer: results from NSABP B-14 and NSABP B-20. (20065188)
2010
14
Molecular anatomy of breast cancer stroma and its prognostic value in estrogen receptor-positive and -negative cancers. (20805453)
2010
15
CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer. (20484027)
2010
16
Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers. (21080930)
2010
17
Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. (20138962)
2010
18
p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells. (24367162)
2009
19
Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer. (19531256)
2009
20
MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer. (18790736)
2008
21
Estrogen induces estrogen-related receptor alpha gene expression and chromatin structural changes in estrogen receptor (ER)-positive and ER-negative breast cancer cells. (18174157)
2008
22
Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. (18413793)
2008
23
Dietary phytoestrogens are not associated with risk of overall breast cancer but diets rich in coumestrol are inversely associated with risk of estrogen receptor and progesterone receptor negative breast tumors in Swedish women. (18424605)
2008
24
Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells. (18313654)
2008
25
The CYP1B1_1358_GG genotype is associated with estrogen receptor-negative breast cancer. (17922187)
2008
26
Estrogen receptor-negative invasive breast cancer: imaging features of tumors with and without human epidermal growth factor receptor type 2 overexpression. (18180338)
2008
27
Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature. (19025599)
2008
28
Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy. (17906205)
2007
29
Efficacy of adjuvant chemotherapy according to Prion protein expression in patients with estrogen receptor-negative breast cancer. (17872899)
2007
30
Growth inhibition and multidrug resistance-reversing effect of tanshinone I A on human breast cancer cell with estrogen receptor negative]. (17593814)
2007
31
Transgenic introduction of androgen receptor into estrogen-receptor-, progesterone-receptor-, and androgen-receptor-negative breast cancer cells renders them responsive to hormonal manipulation. (16647340)
2006
32
Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer. (16331345)
2006
33
Interleukin-1alpha protein secretion in breast cancer is associated with poor differentiation and estrogen receptor alpha negativity. (17010072)
2006
34
Estrogen receptor alpha-negative and progesterone receptor-positive breast cancer: lab error or real entity? (17189985)
2006
35
Diet quality is associated with the risk of estrogen receptor-negative breast cancer in postmenopausal women. (16424129)
2006
36
Selective reduction of estrogen receptor (ER) positive breast cancer occurrence by estrogen receptor modulators supports etiological distinction between ER positive and ER negative breast cancers. (15823713)
2005
37
The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenograftsis attributed to both its lignan and oil components. (15849746)
2005
38
The synergistic inhibitory effect of 5-aza-2-deoxycytidine and Tamoxifen on estrogen receptor alpha negative breast cancer cell lines in vitro]. (16412295)
2005
39
Treatment of axillary lymph node-negative, estrogen receptor-negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trials. (15601638)
2004
40
Efficacy of Vitamin D compounds to modulate estrogen receptor negative breast cancer growth and invasion. (12711002)
2003
41
Androgen receptor expression in estrogen receptor-negative breast cancer. Immunohistochemical, clinical, and prognostic associations. (14608899)
2003
42
Naturally occurring dominant-negative Stat5 suppresses transcriptional activity of estrogen receptors and induces apoptosis in T47D breast cancer cells. (12642867)
2003
43
Increased CpG methylation of the estrogen receptor gene in BRCA1-linked estrogen receptor-negative breast cancers. (12370825)
2002
44
Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells. (11559546)
2001
45
Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen receptor-negative human breast cancer. (9360842)
1997
46
Invasive capacity and regulation of urokinase-type plasminogen activator in estrogen receptor (ER)-negative MDA-MB-231 human breast cancer cells, and a transfectant (S30) stably expressing ER. (8616826)
1996
47
Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression. (7538900)
1995
48
Why are estrogen-receptor-negative breast cancers more aggressive than the estrogen-receptor-positive breast cancers? (7657526)
1994-1995
49
Monitoring the chemosensitizing effects of toremifene with flow cytometry in estrogen receptor negative multidrug resistant human breast cancer cells. (1463871)
1992
50
Adjuvant CMF for node-negative and estrogen receptor-negative breast cancer patients. (1627434)
1992

Genetic Variations for Estrogen-Receptor Negative Breast Cancer

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Expression for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Estrogen-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Estrogen-Receptor Negative Breast Cancer.

Pathways for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Compounds for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources:
59Tocris Bioscience, 44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1skf 96365 hydrochloride5910.7ORAI1, ORAI3, ORAI2
2biochanin a4410.7TFF1, ESRRA
3diethylstilbestrol44 28 1112.7ESRRA, CRAT, TFF1
4estrogen4410.6MSN
5pdtc4410.6FOSL1, CRAT, CHUK
6retinoid4410.6CHUK, CRAT, TFF1, FOSL1
7fatty acid4410.6TFF1, CRAT, CHUK, MSN, ESRRA
812-o-tetradecanoylphorbol 13-acetate4410.5FOSL1, TFF1, CRAT, CHUK
9tamoxifen44 49 28 1113.4TFF1, CRAT, CHUK, ESRRA
10retinoic acid44 2411.4FOSL1, TFF1, CRAT, CHUK, WNT5A, ESRRA
11phorbol4410.4CHUK, CRAT, FOSL1
12hyaluronic acid44 2411.4MSN, CRAT, TFF1
13apigenin44 2811.3TFF1, CHUK
14daidzein4410.1ESRRA, TFF1

GO Terms for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources:
16Gene Ontology
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Biological processes related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell-cell adhesion mediated by cadherinGO:200004910.4WNT5A, FOXA1

Molecular functions related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein domain specific bindingGO:01990410.4ESRRA, WNT5A, FOXA1

Products for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources for Estrogen-Receptor Negative Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet