MCID: EST002
MIFTS: 42

Estrogen-Receptor Negative Breast Cancer malady

Cancer diseases category
Download this MalaCard

Summaries for Estrogen-Receptor Negative Breast Cancer

About this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Estrogen-Receptor Negative Breast Cancer is related to breast cancer and colon cancer. An important gene associated with Estrogen-Receptor Negative Breast Cancer is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are Integrin alphaIIb beta3 signaling and Arf6 signaling events. The compounds cgp77675 and raytide have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and lung, and related mouse phenotypes are integument and vision/eye.

Aliases & Classifications for Estrogen-Receptor Negative Breast Cancer

About this section
Sources:
8Disease Ontology
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

estrogen-receptor negative breast cancer 8


External Ids:

Disease Ontology8 DOID:0060076

Related Diseases for Estrogen-Receptor Negative Breast Cancer

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Estrogen-Receptor Negative Breast Cancer:



Diseases related to estrogen-receptor negative breast cancer

Symptoms for Estrogen-Receptor Negative Breast Cancer

About this section

Drugs & Therapeutics for Estrogen-Receptor Negative Breast Cancer

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Estrogen-Receptor Negative Breast Cancer

Search NIH Clinical Center for Estrogen-Receptor Negative Breast Cancer

Genetic Tests for Estrogen-Receptor Negative Breast Cancer

About this section

Anatomical Context for Estrogen-Receptor Negative Breast Cancer

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Estrogen-Receptor Negative Breast Cancer:

33
Breast, Lymph node, Lung, Colon, Endothelial, Prostate

Animal Models for Estrogen-Receptor Negative Breast Cancer or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Estrogen-Receptor Negative Breast Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6EGF, CCND1, SRC, FYN
2MP:00053918.5FYN, SRC, CCND1, EGF
3MP:00053798.4FYN, PTPN1, CCND1, EGF
4MP:00053867.8FYN, PTPRA, PTPN1, SRC, CCND1
5MP:00053787.4EGF, CCND1, SRC, PTPN1, PTPRA, FYN

Publications for Estrogen-Receptor Negative Breast Cancer

About this section
Sources:
52PubMed
See all sources

Articles related to Estrogen-Receptor Negative Breast Cancer:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
17I^-estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1. (23907016)
2013
2
Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. (24140706)
2013
3
Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women. (23532538)
2013
4
Antineoplastic effects of I+-santalol on estrogen receptor-positive and estrogen receptor-negative breast cancer cells through cell cycle arrest at G2/M phase and induction of apoptosis. (23451128)
2013
5
Prostate stem cell antigen single nucleotide polymorphisms influence risk of estrogen receptor negative breast cancer in Korean females. (22502712)
2012
6
Hydrogen sulfide-releasing aspirin suppresses NF-I_B signaling in estrogen receptor negative breast cancer cells in vitro and in vivo. (22209867)
2012
7
Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer. (22817771)
2012
8
Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells. (22034498)
2012
9
Role of androgen excess in the development of estrogen receptor-positive and estrogen receptor-negative breast cancer. (22843896)
2012
10
Synergy between inhibitors of androgen receptor and MEK has therapeutic implications in estrogen receptor-negative breast cancer. (21457548)
2011
11
Coffee consumption modifies risk of estrogen-receptor negative breast cancer. (21569535)
2011
12
Estrogen Receptor Negative Breast Cancer in India: Do We Really Have Higher Burden of this Subtype? (22693404)
2011
13
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. (22037553)
2011
14
Oral contraceptive use and estrogen receptor-negative breast cancer. (21352688)
2011
15
NFIB is a potential target for estrogen receptor-negative breast cancers. (21925980)
2011
16
Simultaneous liposomal delivery of quercetin and vincristine for enhanced estrogen-receptor-negative breast cancer treatment. (20110806)
2010
17
Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. (20650001)
2010
18
A genome-wide association scan on estrogen receptor-negative breast cancer. (21062454)
2010
19
Epidemiology of health disparities in relation to the biology of estrogen receptor-negative breast cancer. (20816508)
2010
20
Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid. (20027631)
2010
21
p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells. (24367162)
2009
22
Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer. (19808870)
2009
23
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. (19447902)
2009
24
Expression of KAI1/CD82 in distant metastases from estrogen receptor-negative breast cancer. (19549254)
2009
25
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer. (19762336)
2009
26
A novel look into estrogen receptor-negative breast cancer prevention with the natural, multifunctional signal transduction inhibitor deguelin. (19861544)
2009
27
Estrogen receptor-negative breast cancer: new insights into subclassification and targeting. (19825953)
2009
28
Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. (18413793)
2008
29
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. (18974123)
2008
30
Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. (18183590)
2008
31
An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer. (17683518)
2007
32
Translational approaches for the prevention of estrogen receptor-negative breast cancer. (17415091)
2007
33
An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. (16491124)
2006
34
Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer. (16331345)
2006
35
Adjuvant chemotherapy for lymph node-negative, estrogen receptor-negative breast cancer: a tale of three trials. (15601631)
2004
36
Treatment of axillary lymph node-negative, estrogen receptor-negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trials. (15601638)
2004
37
Health-related quality of life in axillary node-negative, estrogen receptor-negative breast cancer patients undergoing AC versus CMF chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel Project B-23. (15319567)
2004
38
Implication of HER-2/neu overexpression for the efficacy of oral fluoropyrimidine-based adjuvant chemotherapy in the patients with estrogen receptor negative breast cancer after surgery. (12680178)
2003
39
Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-23. (11181655)
2001
40
Tamoxifen for patients with estrogen receptor-negative breast cancer. (11560981)
2001
41
Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis. (11309328)
2001
42
Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. (10900013)
2000
43
Activation of the estrogen-signaling pathway by p21(WAF1/CIP1) in estrogen receptor-negative breast cancer cells. (10974076)
2000
44
IRS-1 expression and activation are not sufficient to activate downstream pathways and enable IGF-I growth response in estrogen receptor negative breast cancer cells. (10543935)
1999
45
NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha. (9618523)
1998
46
Estrogen receptor-negative breast cancer cells transfected with estrogen receptor exhibit decreased tumour progression and sensitivity to growth inhibition by estrogen. (11243092)
1997
47
Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. (8662863)
1996
48
An estrogen receptor genetic polymorphism and a history of spontaneous abortion--correlation in women with estrogen receptor positive breast cancer but not in women with estrogen receptor negative breast cancer or in women without cancer. (8219254)
1993
49
Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. (1556769)
1992
50
Adjuvant therapy for stage II, estrogen receptor negative breast cancer. (7348569)
1981

Variations for Estrogen-Receptor Negative Breast Cancer

About this section

Expression for genes affiliated with Estrogen-Receptor Negative Breast Cancer

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Estrogen-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Estrogen-Receptor Negative Breast Cancer.

Pathways for genes affiliated with Estrogen-Receptor Negative Breast Cancer

About this section
Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters, 61Tocris Bioscience, 5Cell Signaling Technology, 30KEGG, 51PharmGKB
See all sources

Pathways related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6PTPN1, SRC
29.5EGF, SRC
39.5EGF, SRC
49.5CCND1, SRC
59.5CCND1, SRC
69.5SRC, CCND1
79.4SRC, FYN
89.4FYN, SRC
99.4FYN, SRC
109.4FYN, SRC
11
Show member pathways
EphrinA-EPHA pathway38
Ephrin A reverse signaling38
9.4SRC, FYN
129.4SRC, FYN
139.4SRC, FYN
149.4FYN, SRC
159.4FYN, SRC
16
Show member pathways
9.4FYN, SRC
179.4FYN, SRC
18
Show member pathways
Insulin Pathway38
9.3PTPN1, PTPRA
199.3PTPN1, PTPRA
209.2SRC, PTPN1, EGF
21
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.2PTPN1, SRC, EGF
229.2PTPN1, SRC, EGF
23
Show member pathways
9.1EGF, SRC, CCND1
249.1SRC, EGF, CCND1
25
Show member pathways
Signaling Pathways in Glioblastoma38
9.1CCND1, EGF, SRC
26
Show member pathways
Signal transduction PTEN pathway60
9.1EGF, CCND1, SRC
27
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.1CCND1, EGF, SRC
28
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1SRC, CCND1, EGF
299.1SRC, EGF, CCND1
309.1CCND1, SRC, EGF
319.1FYN, PTPN1, SRC
329.1SRC, PTPN1, FYN
339.0EGF, SRC, FYN
34
Show member pathways
9.0FYN, SRC, EGF
359.0FYN, EGF, SRC
36
Show member pathways
9.0FYN, EGF, SRC
37
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.0EGF, SRC, FYN
389.0FYN, CCND1, SRC
39
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.0SRC, CCND1, FYN
408.6FYN, PTPN1, SRC, EGF
41
Show member pathways
8.6SRC, PTPN1, EGF, FYN
42
Show member pathways
8.6FYN, PTPRA, SRC
43
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
8.6SRC, PTPN1, FYN, CCND1
44
Show member pathways
8.6EGF, FYN, SRC, CCND1
45
Show member pathways
8.6SRC, FYN, EGF, CCND1
46
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.6CCND1, EGF, FYN, SRC
47
Show member pathways
8.6FYN, EGF, CCND1, SRC
48
Show member pathways
8.3PTPN1, EGF, PTPRA, SRC
49
Show member pathways
8.2CCND1, FYN, PTPN1, SRC, EGF
50
Show member pathways
7.8FYN, EGF, PTPRA, PTPN1, SRC

Compounds for genes affiliated with Estrogen-Receptor Negative Breast Cancer

About this section
Sources:
45Novoseek, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 3BitterDB
See all sources

Compounds related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1cgp77675459.9EGF, SRC
2raytide459.8PTPN1, SRC
3pp 3619.7FYN, SRC
41-naphthyl pp1619.7FYN, SRC
5ag 18459.7EGF, SRC
6pp 1619.7FYN, SRC
7pp 2619.7SRC, FYN
8phenylphosphate45 1110.6PTPN1, SRC
9sorafenib45 51 1111.6EGF, CCND1, PTPN1
104-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine459.4EGF, SRC, FYN
11rottlerin459.4SRC, EGF, CCND1
12cetuximab45 51 1111.4CCND1, CDKN3, EGF
13piceatannol45 61 1111.3CCND1, FYN, SRC
14erbstatin459.3SRC, EGF, CDKN3
15sodium orthovanadate45 6110.3SRC, CDKN3, PTPN1
16diphenyleneiodonium459.3SRC, CDKN3, PTPN1
17staurosporin459.3EGF, SRC, CDKN3
184-hydroxytamoxifen459.3EGF, CCND1, SRC
19ag 1478459.3SRC, EGF, CCND1
20progestin459.2EGF, CCND1, SRC
21suramin45 29 1111.2EGF, SRC, PTPN1
22p-nitrophenyl phosphate459.1PTPRA, PTPN1, CDKN3
23geldanamycin45 51 61 1112.0EGF, CCND1, SRC, FYN
24cytochalasin d45 619.9PTPN1, EGF, CDKN3, SRC
25erlotinib45 51 1110.9EGF, SRC, CCND1, CDKN3
26trastuzumab45 51 1110.9SRC, CCND1, CDKN3, EGF
27gefitinib45 51 1110.9SRC, EGF, CDKN3, CCND1
28gf 109203x45 619.9CDKN3, EGF, SRC, CCND1
29nocodazole45 119.8CDKN3, SRC, EGF
30glycogen45 249.8FYN, PTPN1, CDKN3, CCND1
31gemcitabine45 51 1110.8SRC, CCND1, EGF
32herbimycin a45 619.8EGF, SRC, FYN, CDKN3
33ly294002458.8SRC, CCND1, EGF, CDKN3
34wortmannin458.8EGF, CDKN3, SRC, CCND1
35vanadate458.5PTPN1, EGF, CDKN3, FYN, SRC
36cisplatin45 51 61 1111.5CCND1, CDKN3, EGF, SRC
37testosterone45 61 24 1111.5CDKN3, PTPN1, SRC, CCND1, EGF
38rapamycin458.4FYN, SRC, CCND1, EGF, CDKN3
39phosphoinositide458.4SRC, CDKN3, EGF, CCND1, FYN
40genistein45 29 61 3 24 1113.4CCND1, CDKN3, FYN, SRC, EGF
41adenylate458.3CDKN3, EGF, CCND1, SRC, FYN
42vegf458.3CDKN3, SRC, CCND1, EGF, FYN
43phosphatidylinositol458.0PTPN1, FYN, EGF, SRC, CDKN3, CCND1
44threonine458.0FYN, SRC, EGF, CDKN3, PTPN1, CCND1
45estrogen458.0EGF, FYN, SRC, PTPN1, CCND1, CDKN3
46phosphotyrosine457.7CDKN3, SRC, EGF, PTPN1, PTPRA, FYN
47h2o2457.7PTPN1, PTPRA, SRC, FYN, CDKN3, EGF
48cysteine457.6CDKN3, FYN, PTPRA, SRC, PTPN1, EGF
49serine457.2EGF, PTPN1, FYN, SRC, CCND1, CDKN3
50tyrosine457.2EGF, SRC, CCND1, CDKN3, PTPN1, PTPRA

GO Terms for genes affiliated with Estrogen-Receptor Negative Breast Cancer

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.8EGF, SRC, PTPN1, PTPRA, FYN

Biological processes related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1mammary gland alveolus developmentGO:0607499.8CCND1, EGF
2endoplasmic reticulum unfolded protein responseGO:0309689.6PTPN1, CCND1
3forebrain developmentGO:0309009.5SRC, FYN
4T cell costimulationGO:0312959.5FYN, SRC
5Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380969.4FYN, SRC
6response to ethanolGO:0454719.4FYN, CCND1
7fibroblast growth factor receptor signaling pathwayGO:0085439.3SRC, FYN, EGF
8peptidyl-tyrosine phosphorylationGO:0181089.2EGF, SRC
9epidermal growth factor receptor signaling pathwayGO:0071739.2EGF, SRC, FYN
10neurotrophin TRK receptor signaling pathwayGO:0480119.2FYN, SRC, EGF
11platelet activationGO:0301688.9FYN, SRC, PTPN1, EGF
12peptidyl-tyrosine dephosphorylationGO:0353358.9CDKN3, PTPRA, PTPN1
13blood coagulationGO:0075968.9PTPN1, FYN, SRC, EGF
14axon guidanceGO:0074118.8SRC, PTPRA, FYN

Molecular functions related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1growth factor receptor bindingGO:0708519.5FYN, SRC
2protein tyrosine kinase activityGO:0047139.4FYN, SRC
3non-membrane spanning protein tyrosine kinase activityGO:0047159.3FYN, SRC
4ephrin receptor bindingGO:0468759.2FYN, PTPN1, SRC
5ion channel bindingGO:0443259.1SRC, FYN
6protein tyrosine phosphatase activityGO:0047258.7PTPRA, PTPN1, CDKN3
7protein bindingGO:0055156.7FYN, PTPRA, PTPN1, SRC, EGF, CDKN3

Products for genes affiliated with Estrogen-Receptor Negative Breast Cancer

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Estrogen-Receptor Negative Breast Cancer

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet