MCID: EST002
MIFTS: 34

Estrogen-Receptor Negative Breast Cancer malady

Cancer category

Summaries for Estrogen-Receptor Negative Breast Cancer

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33MalaCards
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MalaCards: Estrogen-Receptor Negative Breast Cancer is related to estrogen-receptor positive breast cancer and vascular cancer. An important gene associated with Estrogen-Receptor Negative Breast Cancer is FOXA1 (forkhead box A1). The compounds skf 96365 hydrochloride and biochanin a have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lymph node.

Aliases & Classifications for Estrogen-Receptor Negative Breast Cancer

Sources:
8Disease Ontology
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

estrogen-receptor negative breast cancer 8


External Ids:

Disease Ontology8 DOID:0060076

Related Diseases for Estrogen-Receptor Negative Breast Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of diseases related to Estrogen-Receptor Negative Breast Cancer:



Diseases related to estrogen-receptor negative breast cancer

Clinical Features for Estrogen-Receptor Negative Breast Cancer

Drugs & Therapeutics for Estrogen-Receptor Negative Breast Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Estrogen-Receptor Negative Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Estrogen-Receptor Negative Breast Cancer

Search NIH Clinical Center for Estrogen-Receptor Negative Breast Cancer

Search CenterWatch for Estrogen-Receptor Negative Breast Cancer

Genetic Tests for Estrogen-Receptor Negative Breast Cancer

Anatomical Context for Estrogen-Receptor Negative Breast Cancer

Sources:
33MalaCards
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MalaCards organs/tissues related to Estrogen-Receptor Negative Breast Cancer:

33
Skin, Brain, Lymph node, Lung, Colon, Breast, Prostate, T cells, B cells, Endothelial

Animal Models for Estrogen-Receptor Negative Breast Cancer or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Estrogen-Receptor Negative Breast Cancer

Sources:
51PubMed
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Articles related to Estrogen-Receptor Negative Breast Cancer:

(show top 50)    (show all 258)
idTitleAuthorsYear
1
Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women. (23532538)
2013
2
Syndecan binding protein (SDCBP) is overexpressed in estrogen receptor negative breast cancers, and is a potential promoter for tumor proliferation. (23533663)
2013
3
Chemotherapeutic Potential of 2-[Piperidinoethoxyphenyl]-3-Phenyl-2H-Benzo(b)pyran in Estrogen Receptor- Negative Breast Cancer Cells: Action via Prevention of EGFR Activation and Combined Inhibition of PI-3-K/Akt/FOXO and MEK/Erk/AP-1 Pathways. (23840429)
2013
4
Hydrogen sulfide-releasing aspirin suppresses NF-I_B signaling in estrogen receptor negative breast cancer cells in vitro and in vivo. (22209867)
2012
5
Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer. (22817771)
2012
6
Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer. (22971289)
2012
7
MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-I_B and TGF-I^ signaling pathways. (22158050)
2012
8
Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids. (23142364)
2012
9
Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study. (22480149)
2012
10
Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer. (21717460)
2012
11
S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor-Negative Breast Cancer. (23543871)
2012
12
Coffee consumption modifies risk of estrogen-receptor negative breast cancer. (21569535)
2011
13
Estrogen Receptor Negative Breast Cancer in India: Do We Really Have Higher Burden of this Subtype? (22693404)
2011
14
Oral contraceptive use and estrogen receptor-negative breast cancer. (21352688)
2011
15
Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer. (21364029)
2011
16
Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. (21868756)
2011
17
Simultaneous liposomal delivery of quercetin and vincristine for enhanced estrogen-receptor-negative breast cancer treatment. (20110806)
2010
18
Association between the 21-gene recurrence score assay and risk of locoregional recurrence in node-negative, estrogen receptor-positive breast cancer: results from NSABP B-14 and NSABP B-20. (20065188)
2010
19
ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancer. (20603605)
2010
20
A shift from nuclear to cytoplasmic breast cancer metastasis suppressor 1 expression is associated with highly proliferative estrogen receptor-negative breast cancers. (19609101)
2009
21
Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. (18830129)
2009
22
The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer. (19414322)
2009
23
Estrogen induces estrogen-related receptor alpha gene expression and chromatin structural changes in estrogen receptor (ER)-positive and ER-negative breast cancer cells. (18174157)
2008
24
A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study. (18771580)
2008
25
Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells. (18313654)
2008
26
The CYP1B1_1358_GG genotype is associated with estrogen receptor-negative breast cancer. (17922187)
2008
27
Estrogen receptor-negative breast cancer is less likely to arise among lipophilic statin users. (18463402)
2008
28
1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways. (17624585)
2008
29
Clinicopathological characteristics and prognostic factors of breast cancer with estrogen- and progesterone-receptor negative and HER-2 overexpression]. (19173993)
2008
30
Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells. (18317449)
2008
31
The role of human epidermal growth factor receptor 2 in the survival of women with estrogen and progesterone receptor-negative, invasive breast cancer: the California Cancer Registry, 1999-2004. (18189290)
2008
32
Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy. (17906205)
2007
33
Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer. (16331345)
2006
34
Estrogen receptor alpha-negative and progesterone receptor-positive breast cancer: lab error or real entity? (17189985)
2006
35
Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors. (16585219)
2006
36
Selective reduction of estrogen receptor (ER) positive breast cancer occurrence by estrogen receptor modulators supports etiological distinction between ER positive and ER negative breast cancers. (15823713)
2005
37
The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenograftsis attributed to both its lignan and oil components. (15849746)
2005
38
Treatment of axillary lymph node-negative, estrogen receptor-negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trials. (15601638)
2004
39
Implication of HER-2/neu overexpression for the efficacy of oral fluoropyrimidine-based adjuvant chemotherapy in the patients with estrogen receptor negative breast cancer after surgery. (12680178)
2003
40
Efficacy of Vitamin D compounds to modulate estrogen receptor negative breast cancer growth and invasion. (12711002)
2003
41
Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells. (11559546)
2001
42
Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen receptor-negative human breast cancer. (9360842)
1997
43
Sequence variants of the estrogen receptor (ER) gene found in breast cancer patients with ER negative and progesterone receptor positive tumors. (8973592)
1996
44
Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression. (7538900)
1995
45
Why are estrogen-receptor-negative breast cancers more aggressive than the estrogen-receptor-positive breast cancers? (7657526)
1994-1995
46
Paradoxical regulation of estrogen-dependent growth factor gene expression in estrogen receptor (ER)-negative human breast cancer cells stably expressing ER. (8050081)
1994
47
Isolation of a heregulin-like growth factor secreted by estrogen receptor-negative MDA-MB-231 human breast cancer cells that stimulates estrogen receptor-positive cells. (8060314)
1994
48
Expression of a constitutively active estrogen receptor variant in the estrogen receptor-negative BT-20 human breast cancer cell line. (8261406)
1993
49
Protein kinase C subspecies in estrogen receptor-positive and -negative human breast cancer cell lines. (2222428)
1990
50
Induction of progesterone receptor in an estrogen, progesterone receptor-negative breast cancer cell line. (3702420)
1986

Genetic Variations for Estrogen-Receptor Negative Breast Cancer

Expression for genes affiliated with Estrogen-Receptor Negative Breast Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Estrogen-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Estrogen-Receptor Negative Breast Cancer.

Pathways for genes affiliated with Estrogen-Receptor Negative Breast Cancer

Compounds for genes affiliated with Estrogen-Receptor Negative Breast Cancer

Sources:
60Tocris Bioscience, 45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1skf 96365 hydrochloride6010.7ORAI3, ORAI1, ORAI2
2biochanin a4510.7ESRRA, TFF1
3diethylstilbestrol45 29 1112.7ESRRA, TFF1, CRAT
4estrogen4510.6MSN
5pdtc4510.6FOSL1, CRAT, CHUK
6retinoid4510.6TFF1, CRAT, CHUK, FOSL1
7fatty acid4510.6CHUK, CRAT, TFF1, MSN, ESRRA
812-o-tetradecanoylphorbol 13-acetate4510.5FOSL1, TFF1, CRAT, CHUK
9tamoxifen45 50 29 1113.4TFF1, ESRRA, CHUK, CRAT
10retinoic acid45 2411.4TFF1, CRAT, FOSL1, ESRRA, CHUK, WNT5A
11phorbol4510.4FOSL1, CHUK, CRAT
12hyaluronic acid45 2411.4CRAT, MSN, TFF1
13apigenin45 2911.3CHUK, TFF1
14daidzein4510.1ESRRA, TFF1

GO Terms for genes affiliated with Estrogen-Receptor Negative Breast Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell-cell adhesion mediated by cadherinGO:200004910.4WNT5A, FOXA1

Molecular functions related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein domain specific bindingGO:01990410.4ESRRA, WNT5A, FOXA1

Products for genes affiliated with Estrogen-Receptor Negative Breast Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Estrogen-Receptor Negative Breast Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet