MCID: EST002
MIFTS: 42

Estrogen-Receptor Negative Breast Cancer malady

Cancer diseases category

Summaries for Estrogen-Receptor Negative Breast Cancer

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34MalaCards
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MalaCards: Estrogen-Receptor Negative Breast Cancer is related to breast cancer and colon cancer. An important gene associated with Estrogen-Receptor Negative Breast Cancer is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are Integrin alphaIIb beta3 signaling and Arf6 signaling events. The compounds cgp77675 and raytide have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and lung, and related mouse phenotypes are integument and vision/eye.

Aliases & Classifications for Estrogen-Receptor Negative Breast Cancer

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Sources:
9Disease Ontology
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

estrogen-receptor negative breast cancer 9


External Ids:

Disease Ontology9 DOID:0060076

Related Diseases for Estrogen-Receptor Negative Breast Cancer

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Estrogen-Receptor Negative Breast Cancer:



Diseases related to estrogen-receptor negative breast cancer

Symptoms for Estrogen-Receptor Negative Breast Cancer

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Drugs & Therapeutics for Estrogen-Receptor Negative Breast Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Estrogen-Receptor Negative Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Estrogen-Receptor Negative Breast Cancer

Search NIH Clinical Center for Estrogen-Receptor Negative Breast Cancer

Search CenterWatch for Estrogen-Receptor Negative Breast Cancer

Genetic Tests for Estrogen-Receptor Negative Breast Cancer

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Anatomical Context for Estrogen-Receptor Negative Breast Cancer

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Sources:
34MalaCards
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MalaCards organs/tissues related to Estrogen-Receptor Negative Breast Cancer:

34
Breast, Lymph node, Lung, Colon, Endothelial, Prostate

Animal Models for Estrogen-Receptor Negative Breast Cancer or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Estrogen-Receptor Negative Breast Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6EGF, CCND1, SRC, FYN
2MP:00053918.5FYN, SRC, CCND1, EGF
3MP:00053798.4FYN, PTPN1, CCND1, EGF
4MP:00053867.8FYN, PTPRA, PTPN1, SRC, CCND1
5MP:00053787.4EGF, CCND1, SRC, PTPN1, PTPRA, FYN

Publications for Estrogen-Receptor Negative Breast Cancer

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Sources:
53PubMed
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Articles related to Estrogen-Receptor Negative Breast Cancer:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
17I^-estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1. (23907016)
2013
2
Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. (24140706)
2013
3
Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women. (23532538)
2013
4
Antineoplastic effects of I+-santalol on estrogen receptor-positive and estrogen receptor-negative breast cancer cells through cell cycle arrest at G2/M phase and induction of apoptosis. (23451128)
2013
5
Prostate stem cell antigen single nucleotide polymorphisms influence risk of estrogen receptor negative breast cancer in Korean females. (22502712)
2012
6
Hydrogen sulfide-releasing aspirin suppresses NF-I_B signaling in estrogen receptor negative breast cancer cells in vitro and in vivo. (22209867)
2012
7
Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer. (22817771)
2012
8
Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells. (22034498)
2012
9
Role of androgen excess in the development of estrogen receptor-positive and estrogen receptor-negative breast cancer. (22843896)
2012
10
Synergy between inhibitors of androgen receptor and MEK has therapeutic implications in estrogen receptor-negative breast cancer. (21457548)
2011
11
Coffee consumption modifies risk of estrogen-receptor negative breast cancer. (21569535)
2011
12
Estrogen Receptor Negative Breast Cancer in India: Do We Really Have Higher Burden of this Subtype? (22693404)
2011
13
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. (22037553)
2011
14
Oral contraceptive use and estrogen receptor-negative breast cancer. (21352688)
2011
15
NFIB is a potential target for estrogen receptor-negative breast cancers. (21925980)
2011
16
Simultaneous liposomal delivery of quercetin and vincristine for enhanced estrogen-receptor-negative breast cancer treatment. (20110806)
2010
17
Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. (20650001)
2010
18
A genome-wide association scan on estrogen receptor-negative breast cancer. (21062454)
2010
19
Epidemiology of health disparities in relation to the biology of estrogen receptor-negative breast cancer. (20816508)
2010
20
Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid. (20027631)
2010
21
p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells. (24367162)
2009
22
Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer. (19808870)
2009
23
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. (19447902)
2009
24
Expression of KAI1/CD82 in distant metastases from estrogen receptor-negative breast cancer. (19549254)
2009
25
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer. (19762336)
2009
26
A novel look into estrogen receptor-negative breast cancer prevention with the natural, multifunctional signal transduction inhibitor deguelin. (19861544)
2009
27
Estrogen receptor-negative breast cancer: new insights into subclassification and targeting. (19825953)
2009
28
Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. (18413793)
2008
29
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. (18974123)
2008
30
Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. (18183590)
2008
31
An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer. (17683518)
2007
32
Translational approaches for the prevention of estrogen receptor-negative breast cancer. (17415091)
2007
33
An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. (16491124)
2006
34
Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer. (16331345)
2006
35
Adjuvant chemotherapy for lymph node-negative, estrogen receptor-negative breast cancer: a tale of three trials. (15601631)
2004
36
Treatment of axillary lymph node-negative, estrogen receptor-negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trials. (15601638)
2004
37
Health-related quality of life in axillary node-negative, estrogen receptor-negative breast cancer patients undergoing AC versus CMF chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel Project B-23. (15319567)
2004
38
Implication of HER-2/neu overexpression for the efficacy of oral fluoropyrimidine-based adjuvant chemotherapy in the patients with estrogen receptor negative breast cancer after surgery. (12680178)
2003
39
Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-23. (11181655)
2001
40
Tamoxifen for patients with estrogen receptor-negative breast cancer. (11560981)
2001
41
Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis. (11309328)
2001
42
Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. (10900013)
2000
43
Activation of the estrogen-signaling pathway by p21(WAF1/CIP1) in estrogen receptor-negative breast cancer cells. (10974076)
2000
44
IRS-1 expression and activation are not sufficient to activate downstream pathways and enable IGF-I growth response in estrogen receptor negative breast cancer cells. (10543935)
1999
45
NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha. (9618523)
1998
46
Estrogen receptor-negative breast cancer cells transfected with estrogen receptor exhibit decreased tumour progression and sensitivity to growth inhibition by estrogen. (11243092)
1997
47
Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. (8662863)
1996
48
An estrogen receptor genetic polymorphism and a history of spontaneous abortion--correlation in women with estrogen receptor positive breast cancer but not in women with estrogen receptor negative breast cancer or in women without cancer. (8219254)
1993
49
Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. (1556769)
1992
50
Adjuvant therapy for stage II, estrogen receptor negative breast cancer. (7348569)
1981

Variations for Estrogen-Receptor Negative Breast Cancer

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Expression for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Estrogen-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Estrogen-Receptor Negative Breast Cancer.

Pathways for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 62Tocris Bioscience, 5Cell Signaling Technology, 31KEGG, 52PharmGKB
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Pathways related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6PTPN1, SRC
29.5EGF, SRC
39.5EGF, SRC
49.5CCND1, SRC
59.5CCND1, SRC
69.5SRC, CCND1
79.4SRC, FYN
89.4FYN, SRC
99.4FYN, SRC
109.4FYN, SRC
11
Show member pathways
EphrinA-EPHA pathway39
Ephrin A reverse signaling39
9.4SRC, FYN
129.4SRC, FYN
139.4SRC, FYN
149.4FYN, SRC
159.4FYN, SRC
16
Show member pathways
9.4FYN, SRC
179.4FYN, SRC
18
Show member pathways
Insulin Pathway39
9.3PTPN1, PTPRA
199.3PTPN1, PTPRA
209.2SRC, PTPN1, EGF
21
Show member pathways
Transcription Receptor mediated HIF regulation61
Development CNTF receptor signaling61
Class IB PI3K non-lipid kinase events39
ErbB2/ErbB3 signaling events39
Development Growth hormone signaling via PI3K AKT and MAPK cascades61
Translation Regulation activity of EIF261
Regulation of lipid metabolism Insulin signaling generic cascades61
Transcription PPAR Pathway61
Cell adhesion PLAU signaling61
Translation Regulation activity of EIF4F61
9.2PTPN1, SRC, EGF
229.2PTPN1, SRC, EGF
23
Show member pathways
9.1EGF, SRC, CCND1
249.1SRC, EGF, CCND1
25
Show member pathways
Signaling Pathways in Glioblastoma39
9.1CCND1, EGF, SRC
26
Show member pathways
Signal transduction PTEN pathway61
9.1EGF, CCND1, SRC
27
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.1CCND1, EGF, SRC
28
Show member pathways
Translation Non genomic rapid action of Androgen Receptor61
9.1SRC, CCND1, EGF
299.1SRC, EGF, CCND1
309.1CCND1, SRC, EGF
319.1FYN, PTPN1, SRC
329.1SRC, PTPN1, FYN
339.0EGF, SRC, FYN
34
Show member pathways
9.0FYN, SRC, EGF
359.0FYN, EGF, SRC
36
Show member pathways
9.0FYN, EGF, SRC
37
Show member pathways
Apoptosis and survival BAD phosphorylation61
Development Alpha 2 adrenergic receptor activation of ERK61
Chemotaxis CXCR4 signaling pathway61
9.0EGF, SRC, FYN
389.0FYN, CCND1, SRC
39
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility61
Cytoskeleton remodeling Integrin outside in signaling61
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases61
Cell adhesion Tight junctions61
Development MAG dependent inhibition of neurite outgrowth61
9.0SRC, CCND1, FYN
408.6FYN, PTPN1, SRC, EGF
41
Show member pathways
8.6SRC, PTPN1, EGF, FYN
42
Show member pathways
8.6FYN, PTPRA, SRC
43
Show member pathways
Prolactin Signaling Pathway39
Development Prolactin receptor signaling61
Leptin signaling pathway39
8.6SRC, PTPN1, FYN, CCND1
44
Show member pathways
8.6EGF, FYN, SRC, CCND1
45
Show member pathways
8.6SRC, FYN, EGF, CCND1
46
Show member pathways
Integrin-mediated cell adhesion39
Focal Adhesion39
8.6CCND1, EGF, FYN, SRC
47
Show member pathways
8.6FYN, EGF, CCND1, SRC
48
Show member pathways
8.3PTPN1, EGF, PTPRA, SRC
49
Show member pathways
8.2CCND1, FYN, PTPN1, SRC, EGF
50
Show member pathways
7.8FYN, EGF, PTPRA, PTPN1, SRC

Compounds for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 3BitterDB
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Compounds related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1cgp77675469.9EGF, SRC
2raytide469.8PTPN1, SRC
3pp 3629.7FYN, SRC
41-naphthyl pp1629.7FYN, SRC
5ag 18469.7EGF, SRC
6pp 1629.7FYN, SRC
7pp 2629.7SRC, FYN
8phenylphosphate46 1210.6PTPN1, SRC
9sorafenib46 52 1211.6EGF, CCND1, PTPN1
104-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine469.4EGF, SRC, FYN
11rottlerin469.4SRC, EGF, CCND1
12cetuximab46 52 1211.4CCND1, CDKN3, EGF
13piceatannol46 62 1211.3CCND1, FYN, SRC
14erbstatin469.3SRC, EGF, CDKN3
15sodium orthovanadate46 6210.3SRC, CDKN3, PTPN1
16diphenyleneiodonium469.3SRC, CDKN3, PTPN1
17staurosporin469.3EGF, SRC, CDKN3
184-hydroxytamoxifen469.3EGF, CCND1, SRC
19ag 1478469.3SRC, EGF, CCND1
20progestin469.2EGF, CCND1, SRC
21suramin46 30 1211.2EGF, SRC, PTPN1
22p-nitrophenyl phosphate469.1PTPRA, PTPN1, CDKN3
23geldanamycin46 52 62 1212.0EGF, CCND1, SRC, FYN
24cytochalasin d46 629.9PTPN1, EGF, CDKN3, SRC
25erlotinib46 52 1210.9EGF, SRC, CCND1, CDKN3
26trastuzumab46 52 1210.9SRC, CCND1, CDKN3, EGF
27gefitinib46 52 1210.9SRC, EGF, CDKN3, CCND1
28gf 109203x46 629.9CDKN3, EGF, SRC, CCND1
29nocodazole46 129.8CDKN3, SRC, EGF
30glycogen46 259.8FYN, PTPN1, CDKN3, CCND1
31gemcitabine46 52 1210.8SRC, CCND1, EGF
32herbimycin a46 629.8EGF, SRC, FYN, CDKN3
33ly294002468.8SRC, CCND1, EGF, CDKN3
34wortmannin468.8EGF, CDKN3, SRC, CCND1
35vanadate468.5PTPN1, EGF, CDKN3, FYN, SRC
36cisplatin46 52 62 1211.5CCND1, CDKN3, EGF, SRC
37testosterone46 62 25 1211.5CDKN3, PTPN1, SRC, CCND1, EGF
38rapamycin468.4FYN, SRC, CCND1, EGF, CDKN3
39phosphoinositide468.4SRC, CDKN3, EGF, CCND1, FYN
40genistein46 30 62 3 25 1213.4CCND1, CDKN3, FYN, SRC, EGF
41adenylate468.3CDKN3, EGF, CCND1, SRC, FYN
42vegf468.3CDKN3, SRC, CCND1, EGF, FYN
43phosphatidylinositol468.0PTPN1, FYN, EGF, SRC, CDKN3, CCND1
44threonine468.0FYN, SRC, EGF, CDKN3, PTPN1, CCND1
45estrogen468.0EGF, FYN, SRC, PTPN1, CCND1, CDKN3
46phosphotyrosine467.7CDKN3, SRC, EGF, PTPN1, PTPRA, FYN
47h2o2467.7PTPN1, PTPRA, SRC, FYN, CDKN3, EGF
48cysteine467.6CDKN3, FYN, PTPRA, SRC, PTPN1, EGF
49serine467.2EGF, PTPN1, FYN, SRC, CCND1, CDKN3
50tyrosine467.2EGF, SRC, CCND1, CDKN3, PTPN1, PTPRA

GO Terms for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources:
17Gene Ontology
See all sources

Cellular components related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.8EGF, SRC, PTPN1, PTPRA, FYN

Biological processes related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1mammary gland alveolus developmentGO:0607499.8CCND1, EGF
2endoplasmic reticulum unfolded protein responseGO:0309689.6PTPN1, CCND1
3forebrain developmentGO:0309009.5SRC, FYN
4T cell costimulationGO:0312959.5FYN, SRC
5Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380969.4FYN, SRC
6response to ethanolGO:0454719.4FYN, CCND1
7fibroblast growth factor receptor signaling pathwayGO:0085439.3SRC, FYN, EGF
8peptidyl-tyrosine phosphorylationGO:0181089.2EGF, SRC
9epidermal growth factor receptor signaling pathwayGO:0071739.2EGF, SRC, FYN
10neurotrophin TRK receptor signaling pathwayGO:0480119.2FYN, SRC, EGF
11platelet activationGO:0301688.9FYN, SRC, PTPN1, EGF
12peptidyl-tyrosine dephosphorylationGO:0353358.9CDKN3, PTPRA, PTPN1
13blood coagulationGO:0075968.9PTPN1, FYN, SRC, EGF
14axon guidanceGO:0074118.8SRC, PTPRA, FYN

Molecular functions related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1growth factor receptor bindingGO:0708519.5FYN, SRC
2protein tyrosine kinase activityGO:0047139.4FYN, SRC
3non-membrane spanning protein tyrosine kinase activityGO:0047159.3FYN, SRC
4ephrin receptor bindingGO:0468759.2FYN, PTPN1, SRC
5ion channel bindingGO:0443259.1SRC, FYN
6protein tyrosine phosphatase activityGO:0047258.7PTPRA, PTPN1, CDKN3
7protein bindingGO:0055156.7FYN, PTPRA, PTPN1, SRC, EGF, CDKN3

Products for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources for Estrogen-Receptor Negative Breast Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet