MCID: EST002
MIFTS: 43

Estrogen-Receptor Negative Breast Cancer malady

Cancer diseases category
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Summaries for Estrogen-Receptor Negative Breast Cancer

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MalaCards based summary: Estrogen-Receptor Negative Breast Cancer is related to breast cancer and estrogen-receptor positive breast cancer. An important gene associated with Estrogen-Receptor Negative Breast Cancer is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are Integrin alphaIIb beta3 signaling and Internalization of ErbB1. The compounds cgp77675 and raytide have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and colon, and related mouse phenotypes are integument and vision/eye.

Aliases & Classifications for Estrogen-Receptor Negative Breast Cancer

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Estrogen-Receptor Negative Breast Cancer, Aliases & Descriptions:

Name: Estrogen-Receptor Negative Breast Cancer 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:0060076

Related Diseases for Estrogen-Receptor Negative Breast Cancer

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Graphical network of the top 20 diseases related to Estrogen-Receptor Negative Breast Cancer:



Diseases related to estrogen-receptor negative breast cancer

Symptoms for Estrogen-Receptor Negative Breast Cancer

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Drugs & Therapeutics for Estrogen-Receptor Negative Breast Cancer

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Drug clinical trials:

Search ClinicalTrials for Estrogen-Receptor Negative Breast Cancer

Search NIH Clinical Center for Estrogen-Receptor Negative Breast Cancer

Genetic Tests for Estrogen-Receptor Negative Breast Cancer

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Anatomical Context for Estrogen-Receptor Negative Breast Cancer

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MalaCards organs/tissues related to Estrogen-Receptor Negative Breast Cancer:

32
Breast, Lymph node, Colon, Lung, Prostate, Endothelial

Animal Models for Estrogen-Receptor Negative Breast Cancer or affiliated genes

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MGI Mouse Phenotypes related to Estrogen-Receptor Negative Breast Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6EGF, CCND1, SRC, FYN
2MP:00053918.5FYN, SRC, CCND1, EGF
3MP:00053798.4FYN, PTPN1, CCND1, EGF
4MP:00053867.8FYN, PTPRA, PTPN1, SRC, CCND1
5MP:00053787.4EGF, CCND1, SRC, PTPN1, PTPRA, FYN

Publications for Estrogen-Receptor Negative Breast Cancer

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Articles related to Estrogen-Receptor Negative Breast Cancer:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach. (24678876)
2014
2
Metabolic differences in estrogen receptor-negative breast cancer based on androgen receptor status. (24850180)
2014
3
The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo. (25275589)
2014
4
Expression of Reactive Oxygen Species-Related Proteins according to Androgen and HER-2 Status in Estrogen Receptor-Negative Breast Cancer. (25322848)
2014
5
17I^-estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1. (23907016)
2013
6
Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. (24140706)
2013
7
Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women. (23532538)
2013
8
Antineoplastic effects of I+-santalol on estrogen receptor-positive and estrogen receptor-negative breast cancer cells through cell cycle arrest at G2/M phase and induction of apoptosis. (23451128)
2013
9
Prostate stem cell antigen single nucleotide polymorphisms influence risk of estrogen receptor negative breast cancer in Korean females. (22502712)
2012
10
Hydrogen sulfide-releasing aspirin suppresses NF-I_B signaling in estrogen receptor negative breast cancer cells in vitro and in vivo. (22209867)
2012
11
Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer. (22817771)
2012
12
Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells. (22034498)
2012
13
Role of androgen excess in the development of estrogen receptor-positive and estrogen receptor-negative breast cancer. (22843896)
2012
14
Synergy between inhibitors of androgen receptor and MEK has therapeutic implications in estrogen receptor-negative breast cancer. (21457548)
2011
15
Coffee consumption modifies risk of estrogen-receptor negative breast cancer. (21569535)
2011
16
Estrogen Receptor Negative Breast Cancer in India: Do We Really Have Higher Burden of this Subtype? (22693404)
2011
17
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. (22037553)
2011
18
Oral contraceptive use and estrogen receptor-negative breast cancer. (21352688)
2011
19
NFIB is a potential target for estrogen receptor-negative breast cancers. (21925980)
2011
20
Simultaneous liposomal delivery of quercetin and vincristine for enhanced estrogen-receptor-negative breast cancer treatment. (20110806)
2010
21
Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. (20650001)
2010
22
A genome-wide association scan on estrogen receptor-negative breast cancer. (21062454)
2010
23
Epidemiology of health disparities in relation to the biology of estrogen receptor-negative breast cancer. (20816508)
2010
24
Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid. (20027631)
2010
25
p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells. (24367162)
2009
26
Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer. (19808870)
2009
27
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. (19447902)
2009
28
Expression of KAI1/CD82 in distant metastases from estrogen receptor-negative breast cancer. (19549254)
2009
29
A novel look into estrogen receptor-negative breast cancer prevention with the natural, multifunctional signal transduction inhibitor deguelin. (19861544)
2009
30
Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. (18413793)
2008
31
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. (18974123)
2008
32
Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. (18183590)
2008
33
An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer. (17683518)
2007
34
Translational approaches for the prevention of estrogen receptor-negative breast cancer. (17415091)
2007
35
An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. (16491124)
2006
36
Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer. (16331345)
2006
37
Adjuvant chemotherapy for lymph node-negative, estrogen receptor-negative breast cancer: a tale of three trials. (15601631)
2004
38
Treatment of axillary lymph node-negative, estrogen receptor-negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trials. (15601638)
2004
39
Health-related quality of life in axillary node-negative, estrogen receptor-negative breast cancer patients undergoing AC versus CMF chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel Project B-23. (15319567)
2004
40
Implication of HER-2/neu overexpression for the efficacy of oral fluoropyrimidine-based adjuvant chemotherapy in the patients with estrogen receptor negative breast cancer after surgery. (12680178)
2003
41
Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-23. (11181655)
2001
42
Tamoxifen for patients with estrogen receptor-negative breast cancer. (11560981)
2001
43
Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis. (11309328)
2001
44
Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. (10900013)
2000
45
NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha. (9618523)
1998
46
Estrogen receptor-negative breast cancer cells transfected with estrogen receptor exhibit decreased tumour progression and sensitivity to growth inhibition by estrogen. (11243092)
1997
47
Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. (8662863)
1996
48
An estrogen receptor genetic polymorphism and a history of spontaneous abortion--correlation in women with estrogen receptor positive breast cancer but not in women with estrogen receptor negative breast cancer or in women without cancer. (8219254)
1993
49
Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. (1556769)
1992
50
Adjuvant therapy for stage II, estrogen receptor negative breast cancer. (7348569)
1981

Variations for Estrogen-Receptor Negative Breast Cancer

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Expression for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Expression patterns in normal tissues for genes affiliated with Estrogen-Receptor Negative Breast Cancer

Search GEO for disease gene expression data for Estrogen-Receptor Negative Breast Cancer.

Pathways for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Pathways related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6SRC, PTPN1
29.5SRC, EGF
39.5SRC, EGF
49.5SRC, CCND1
59.5CCND1, SRC
69.5CCND1, SRC
79.4SRC, FYN
8
Show member pathways
EphrinA-EPHA pathway37
Ephrin A reverse signaling37
9.4SRC, FYN
99.4FYN, SRC
109.4FYN, SRC
11
Show member pathways
9.4SRC, FYN
129.4FYN, SRC
139.4SRC, FYN
149.4FYN, SRC
159.4FYN, SRC
169.4SRC, FYN
179.4SRC, FYN
189.3PTPN1, PTPRA
19
Show member pathways
Insulin Pathway37
9.3PTPN1, PTPRA
20
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.2PTPN1, SRC, EGF
219.2PTPN1, SRC, EGF
229.2PTPN1, SRC, EGF
239.1EGF, CCND1, SRC
24
Show member pathways
9.1SRC, CCND1, EGF
25
Show member pathways
Signaling Pathways in Glioblastoma37
9.1EGF, CCND1, SRC
269.1EGF, CCND1, SRC
279.1EGF, CCND1, SRC
28
Show member pathways
Signal transduction PTEN pathway60
9.1EGF, CCND1, SRC
29
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.1SRC, CCND1, EGF
30
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1SRC, CCND1, EGF
319.1FYN, PTPN1, SRC
329.1SRC, PTPN1, FYN
339.0EGF, SRC, FYN
34
Show member pathways
9.0EGF, SRC, FYN
359.0EGF, SRC, FYN
36
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.0EGF, SRC, FYN
37
Show member pathways
9.0EGF, SRC, FYN
38
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
9.0FYN, SRC, CCND1
399.0FYN, SRC, CCND1
40
Show member pathways
8.6EGF, SRC, PTPN1, FYN
418.6EGF, SRC, PTPN1, FYN
42
Show member pathways
8.6SRC, PTPRA, FYN
43
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
8.6CCND1, SRC, PTPN1, FYN
44
Show member pathways
8.6FYN, SRC, CCND1, EGF
45
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.6FYN, SRC, CCND1, EGF
46
Show member pathways
8.6FYN, SRC, CCND1, EGF
47
Show member pathways
8.6EGF, CCND1, SRC, FYN
48
Show member pathways
8.3PTPRA, PTPN1, SRC, EGF
49
Show member pathways
8.2FYN, PTPN1, SRC, CCND1, EGF
50
Show member pathways
7.8EGF, SRC, PTPN1, PTPRA, FYN

Compounds for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Compounds related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1cgp77675449.9EGF, SRC
2raytide449.8PTPN1, SRC
3pp 3619.7FYN, SRC
41-naphthyl pp1619.7FYN, SRC
5ag 18449.7EGF, SRC
6pp 1619.7FYN, SRC
7pp 2619.7SRC, FYN
8phenylphosphate44 1110.6PTPN1, SRC
9sorafenib44 50 1111.6EGF, CCND1, PTPN1
104-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine449.4EGF, SRC, FYN
11rottlerin449.4SRC, EGF, CCND1
12cetuximab44 50 1111.4CCND1, CDKN3, EGF
13piceatannol44 61 1111.3CCND1, FYN, SRC
14erbstatin449.3SRC, EGF, CDKN3
15sodium orthovanadate44 6110.3SRC, CDKN3, PTPN1
16diphenyleneiodonium449.3SRC, CDKN3, PTPN1
17staurosporin449.3EGF, SRC, CDKN3
184-hydroxytamoxifen449.3EGF, CCND1, SRC
19ag 1478449.3SRC, EGF, CCND1
20progestin449.2EGF, CCND1, SRC
21suramin44 28 1111.2EGF, SRC, PTPN1
22p-nitrophenyl phosphate449.1PTPRA, PTPN1, CDKN3
23geldanamycin44 50 61 1112.0EGF, CCND1, SRC, FYN
24cytochalasin d44 619.9PTPN1, EGF, CDKN3, SRC
25erlotinib44 50 1110.9EGF, SRC, CCND1, CDKN3
26trastuzumab44 50 1110.9SRC, CCND1, CDKN3, EGF
27gefitinib44 50 1110.9SRC, EGF, CDKN3, CCND1
28gf 109203x44 619.9CDKN3, EGF, SRC, CCND1
29nocodazole44 119.8CDKN3, SRC, EGF
30glycogen44 249.8FYN, PTPN1, CDKN3, CCND1
31gemcitabine44 50 1110.8SRC, CCND1, EGF
32herbimycin a44 619.8EGF, SRC, FYN, CDKN3
33ly294002448.8SRC, CCND1, EGF, CDKN3
34wortmannin448.8EGF, CDKN3, SRC, CCND1
35vanadate448.5PTPN1, EGF, CDKN3, FYN, SRC
36cisplatin44 50 61 1111.5CCND1, CDKN3, EGF, SRC
37testosterone44 61 24 1111.5CDKN3, PTPN1, SRC, CCND1, EGF
38rapamycin448.4FYN, SRC, CCND1, EGF, CDKN3
39phosphoinositide448.4SRC, CDKN3, EGF, CCND1, FYN
40genistein44 28 61 2 24 1113.4CCND1, CDKN3, FYN, SRC, EGF
41adenylate448.3CDKN3, EGF, CCND1, SRC, FYN
42vegf448.3CDKN3, SRC, CCND1, EGF, FYN
43phosphatidylinositol448.0PTPN1, FYN, EGF, SRC, CDKN3, CCND1
44threonine448.0FYN, SRC, EGF, CDKN3, PTPN1, CCND1
45estrogen448.0EGF, FYN, SRC, PTPN1, CCND1, CDKN3
46phosphotyrosine447.7CDKN3, SRC, EGF, PTPN1, PTPRA, FYN
47h2o2447.7PTPN1, PTPRA, SRC, FYN, CDKN3, EGF
48cysteine447.6CDKN3, FYN, PTPRA, SRC, PTPN1, EGF
49serine447.2EGF, PTPN1, FYN, SRC, CCND1, CDKN3
50tyrosine447.2EGF, SRC, CCND1, CDKN3, PTPN1, PTPRA

GO Terms for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Cellular components related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.8EGF, SRC, PTPN1, PTPRA, FYN

Biological processes related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1mammary gland alveolus developmentGO:0607499.8EGF, CCND1
2endoplasmic reticulum unfolded protein responseGO:0309689.6CCND1, PTPN1
3forebrain developmentGO:0309009.5SRC, FYN
4T cell costimulationGO:0312959.5FYN, SRC
5Fc-gamma receptor signaling pathway involved in phagocytosisGO:0380969.4SRC, FYN
6response to ethanolGO:0454719.4CCND1, FYN
7fibroblast growth factor receptor signaling pathwayGO:0085439.3EGF, SRC, FYN
8peptidyl-tyrosine phosphorylationGO:0181089.2EGF, SRC
9epidermal growth factor receptor signaling pathwayGO:0071739.2FYN, SRC, EGF
10neurotrophin TRK receptor signaling pathwayGO:0480119.2EGF, SRC, FYN
11platelet activationGO:0301688.9EGF, SRC, PTPN1, FYN
12peptidyl-tyrosine dephosphorylationGO:0353358.9CDKN3, PTPN1, PTPRA
13blood coagulationGO:0075968.9FYN, PTPN1, SRC, EGF
14axon guidanceGO:0074118.8FYN, PTPRA, SRC

Molecular functions related to Estrogen-Receptor Negative Breast Cancer according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1growth factor receptor bindingGO:0708519.5SRC, FYN
2protein tyrosine kinase activityGO:0047139.4SRC, FYN
3non-membrane spanning protein tyrosine kinase activityGO:0047159.3SRC, FYN
4ephrin receptor bindingGO:0468759.2SRC, PTPN1, FYN
5ion channel bindingGO:0443259.1SRC, FYN
6protein tyrosine phosphatase activityGO:0047258.7PTPRA, PTPN1, CDKN3
7protein bindingGO:0055156.7FYN, PTPRA, PTPN1, SRC, CCND1, CDKN3

Products for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources for Estrogen-Receptor Negative Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet