MCID: EST002
MIFTS: 36

Estrogen-Receptor Negative Breast Cancer malady

Cancer diseases category

Aliases & Classifications for Estrogen-Receptor Negative Breast Cancer

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Estrogen-Receptor Negative Breast Cancer, Aliases & Descriptions:

Name: Estrogen-Receptor Negative Breast Cancer 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:0060076

Summaries for Estrogen-Receptor Negative Breast Cancer

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MalaCards based summary: Estrogen-Receptor Negative Breast Cancer is related to breast cancer and estrogen-receptor positive breast cancer. An important gene associated with Estrogen-Receptor Negative Breast Cancer is PTPN1 (protein tyrosine phosphatase, non-receptor type 1), and among its related pathways are Integrin alphaIIb beta3 signaling and Internalization of ErbB1. The compounds cgp77675 and raytide have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and colon, and related mouse phenotypes are integument and vision/eye.

Related Diseases for Estrogen-Receptor Negative Breast Cancer

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Graphical network of the top 20 diseases related to Estrogen-Receptor Negative Breast Cancer:



Diseases related to estrogen-receptor negative breast cancer

Symptoms for Estrogen-Receptor Negative Breast Cancer

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Drugs & Therapeutics for Estrogen-Receptor Negative Breast Cancer

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Drug clinical trials:

Search ClinicalTrials for Estrogen-Receptor Negative Breast Cancer

Search NIH Clinical Center for Estrogen-Receptor Negative Breast Cancer

Genetic Tests for Estrogen-Receptor Negative Breast Cancer

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Anatomical Context for Estrogen-Receptor Negative Breast Cancer

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MalaCards organs/tissues related to Estrogen-Receptor Negative Breast Cancer:

31
Breast, Lymph node, Colon, Lung, Prostate, Endothelial

Animal Models for Estrogen-Receptor Negative Breast Cancer or affiliated genes

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MGI Mouse Phenotypes related to Estrogen-Receptor Negative Breast Cancer:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.6EGF, CCND1, SRC, FYN
2MP:00053918.5FYN, SRC, CCND1, EGF
3MP:00053798.4FYN, PTPN1, CCND1, EGF
4MP:00053867.8FYN, PTPRA, PTPN1, SRC, CCND1
5MP:00053787.4EGF, CCND1, SRC, PTPN1, PTPRA, FYN

Publications for Estrogen-Receptor Negative Breast Cancer

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Articles related to Estrogen-Receptor Negative Breast Cancer:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Beyond immune density: critical role of spatial heterogeneity in estrogen receptor-negative breast cancer. (25720324)
2015
2
The prevalence of estrogen receptor-negative breast cancer in Ethiopia. (25433805)
2014
3
Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach. (24678876)
2014
4
Metabolic differences in estrogen receptor-negative breast cancer based on androgen receptor status. (24850180)
2014
5
The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo. (25275589)
2014
6
Expression of Reactive Oxygen Species-Related Proteins according to Androgen and HER-2 Status in Estrogen Receptor-Negative Breast Cancer. (25322848)
2014
7
17I^-estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1. (23907016)
2013
8
Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation. (24140706)
2013
9
Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women. (23532538)
2013
10
Antineoplastic effects of I+-santalol on estrogen receptor-positive and estrogen receptor-negative breast cancer cells through cell cycle arrest at G2/M phase and induction of apoptosis. (23451128)
2013
11
Prostate stem cell antigen single nucleotide polymorphisms influence risk of estrogen receptor negative breast cancer in Korean females. (22502712)
2012
12
Hydrogen sulfide-releasing aspirin suppresses NF-I_B signaling in estrogen receptor negative breast cancer cells in vitro and in vivo. (22209867)
2012
13
Prolactin-induced protein mediates cell invasion and regulates integrin signaling in estrogen receptor-negative breast cancer. (22817771)
2012
14
Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells. (22034498)
2012
15
Role of androgen excess in the development of estrogen receptor-positive and estrogen receptor-negative breast cancer. (22843896)
2012
16
Synergy between inhibitors of androgen receptor and MEK has therapeutic implications in estrogen receptor-negative breast cancer. (21457548)
2011
17
Coffee consumption modifies risk of estrogen-receptor negative breast cancer. (21569535)
2011
18
Estrogen Receptor Negative Breast Cancer in India: Do We Really Have Higher Burden of this Subtype? (22693404)
2011
19
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. (22037553)
2011
20
Oral contraceptive use and estrogen receptor-negative breast cancer. (21352688)
2011
21
NFIB is a potential target for estrogen receptor-negative breast cancers. (21925980)
2011
22
Simultaneous liposomal delivery of quercetin and vincristine for enhanced estrogen-receptor-negative breast cancer treatment. (20110806)
2010
23
Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. (20650001)
2010
24
A genome-wide association scan on estrogen receptor-negative breast cancer. (21062454)
2010
25
Epidemiology of health disparities in relation to the biology of estrogen receptor-negative breast cancer. (20816508)
2010
26
p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells. (24367162)
2009
27
Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer. (19808870)
2009
28
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. (19447902)
2009
29
Expression of KAI1/CD82 in distant metastases from estrogen receptor-negative breast cancer. (19549254)
2009
30
A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer. (19762336)
2009
31
Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. (18413793)
2008
32
Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer. (18974123)
2008
33
Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. (18183590)
2008
34
An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer. (17683518)
2007
35
An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. (16491124)
2006
36
Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer. (16331345)
2006
37
Adjuvant chemotherapy for lymph node-negative, estrogen receptor-negative breast cancer: a tale of three trials. (15601631)
2004
38
Treatment of axillary lymph node-negative, estrogen receptor-negative breast cancer: updated findings from National Surgical Adjuvant Breast and Bowel Project clinical trials. (15601638)
2004
39
Health-related quality of life in axillary node-negative, estrogen receptor-negative breast cancer patients undergoing AC versus CMF chemotherapy: findings from the National Surgical Adjuvant Breast and Bowel Project B-23. (15319567)
2004
40
Implication of HER-2/neu overexpression for the efficacy of oral fluoropyrimidine-based adjuvant chemotherapy in the patients with estrogen receptor negative breast cancer after surgery. (12680178)
2003
41
Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-23. (11181655)
2001
42
Tamoxifen for patients with estrogen receptor-negative breast cancer. (11560981)
2001
43
Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis. (11309328)
2001
44
Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. (10900013)
2000
45
NF-kappaB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1alpha. (9618523)
1998
46
Estrogen receptor-negative breast cancer cells transfected with estrogen receptor exhibit decreased tumour progression and sensitivity to growth inhibition by estrogen. (11243092)
1997
47
Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. (8662863)
1996
48
An estrogen receptor genetic polymorphism and a history of spontaneous abortion--correlation in women with estrogen receptor positive breast cancer but not in women with estrogen receptor negative breast cancer or in women without cancer. (8219254)
1993
49
Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. (1556769)
1992
50
Adjuvant therapy for stage II, estrogen receptor negative breast cancer. (7348569)
1981

Variations for Estrogen-Receptor Negative Breast Cancer

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Expression for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Search GEO for disease gene expression data for Estrogen-Receptor Negative Breast Cancer.

Pathways for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Pathways related to Estrogen-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6SRC, PTPN1
29.5SRC, EGF
39.5SRC, EGF
49.5CCND1, SRC
59.5CCND1, SRC
69.5SRC, CCND1
79.4SRC, FYN
89.4FYN, SRC
9
Show member pathways
EphrinA-EPHA pathway36
Ephrin A reverse signaling36
9.4SRC, FYN
109.4FYN, SRC
119.4SRC, FYN
129.4SRC, FYN
139.4FYN, SRC
149.4SRC, FYN
159.4FYN, SRC
169.4FYN, SRC
17
Show member pathways
Insulin Pathway36
9.3PTPN1, PTPRA
189.3PTPN1, PTPRA
19
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
9.2PTPN1, SRC, EGF
209.2PTPN1, SRC, EGF
219.2PTPN1, SRC, EGF
229.1SRC, PTPRA
23
Show member pathways
9.1SRC, CCND1, EGF
249.1EGF, CCND1, SRC
25
Show member pathways
Signaling Pathways in Glioblastoma36
9.1EGF, CCND1, SRC
269.1EGF, CCND1, SRC
279.1EGF, CCND1, SRC
28
Show member pathways
Signal transduction PTEN pathway58
9.1EGF, CCND1, SRC
29
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.1SRC, CCND1, EGF
30
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.1SRC, CCND1, EGF
319.1FYN, PTPN1, SRC
329.1SRC, PTPN1, FYN
339.0EGF, SRC, FYN
34
Show member pathways
9.0EGF, SRC, FYN
359.0EGF, SRC, FYN
36
Show member pathways
Apoptosis and survival BAD phosphorylation58
Development Alpha 2 adrenergic receptor activation of ERK58
Chemotaxis CXCR4 signaling pathway58
9.0EGF, SRC, FYN
37
Show member pathways
9.0EGF, SRC, FYN
38
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
9.0FYN, SRC, CCND1
399.0FYN, SRC, CCND1
40
Show member pathways
8.6EGF, SRC, PTPN1, FYN
418.6EGF, SRC, PTPN1, FYN
42
Show member pathways
8.6SRC, PTPRA, FYN
43
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
8.6CCND1, SRC, PTPN1, FYN
44
Show member pathways
8.6FYN, SRC, CCND1, EGF
45
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
8.6FYN, SRC, CCND1, EGF
46
Show member pathways
8.6FYN, SRC, CCND1, EGF
47
Show member pathways
8.6EGF, CCND1, SRC, FYN
48
Show member pathways
8.3PTPRA, PTPN1, SRC, EGF
49
Show member pathways
8.2FYN, PTPN1, SRC, CCND1, EGF
50
Show member pathways
7.8EGF, SRC, PTPN1, PTPRA, FYN

Compounds for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Compounds related to Estrogen-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1cgp77675439.9EGF, SRC
2raytide439.9PTPN1, SRC
3pp 3599.7FYN, SRC
4ag 18439.7EGF, SRC
51-naphthyl pp1599.7FYN, SRC
6pp 1599.7FYN, SRC
7pp 2599.7FYN, SRC
8phenylphosphate43 1210.6SRC, PTPN1
9sorafenib43 49 1211.6PTPN1, CCND1, EGF
104-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine439.4EGF, SRC, FYN
11rottlerin439.4SRC, CCND1, EGF
12cetuximab43 49 1211.4CCND1, CDKN3, EGF
13piceatannol43 59 1211.3CCND1, SRC, FYN
14erbstatin439.3EGF, CDKN3, SRC
15sodium orthovanadate43 5910.3PTPN1, SRC, CDKN3
16diphenyleneiodonium439.3PTPN1, SRC, CDKN3
17staurosporin439.3EGF, CDKN3, SRC
184-hydroxytamoxifen439.3SRC, CCND1, EGF
19ag 1478439.3EGF, CCND1, SRC
20progestin439.2SRC, CCND1, EGF
21suramin43 28 1211.2EGF, SRC, PTPN1
22p-nitrophenyl phosphate439.1PTPRA, PTPN1, CDKN3
23gemcitabine43 49 1211.0SRC, CCND1, EGF
24geldanamycin43 49 59 1212.0EGF, CCND1, SRC, FYN
25cytochalasin d43 599.9EGF, CDKN3, SRC, PTPN1
26erlotinib43 49 1210.9SRC, CCND1, CDKN3, EGF
27trastuzumab43 49 1210.9SRC, CCND1, CDKN3, EGF
28gefitinib43 49 1210.9SRC, CCND1, CDKN3, EGF
29gf 109203x43 599.9SRC, CCND1, CDKN3, EGF
30glycogen43 249.8CDKN3, CCND1, PTPN1, FYN
31herbimycin a43 599.8FYN, SRC, CDKN3, EGF
32ly294002438.8SRC, CCND1, CDKN3, EGF
33wortmannin438.8SRC, CCND1, CDKN3, EGF
34nocodazole43 129.6SRC, CDKN3, EGF
35vanadate438.5FYN, PTPN1, SRC, CDKN3, EGF
36cisplatin43 49 59 1211.5SRC, CCND1, CDKN3, EGF
37testosterone43 59 24 1211.5PTPN1, SRC, CCND1, CDKN3, EGF
38rapamycin438.4FYN, SRC, CCND1, CDKN3, EGF
39phosphoinositide438.4FYN, SRC, CCND1, CDKN3, EGF
40genistein43 28 59 2 24 1213.4FYN, SRC, CCND1, CDKN3, EGF
41adenylate438.3FYN, SRC, CCND1, CDKN3, EGF
42vegf438.3FYN, SRC, CCND1, CDKN3, EGF
43phosphatidylinositol438.0FYN, PTPN1, SRC, CCND1, CDKN3, EGF
44threonine438.0FYN, PTPN1, SRC, CCND1, CDKN3, EGF
45estrogen438.0FYN, PTPN1, SRC, CCND1, CDKN3, EGF
46phosphotyrosine437.7EGF, CDKN3, SRC, PTPN1, PTPRA, FYN
47h2o2437.7FYN, PTPRA, PTPN1, SRC, CDKN3, EGF
48cysteine437.6FYN, PTPRA, PTPN1, SRC, CDKN3, EGF
49serine437.2FYN, PTPRA, PTPN1, SRC, CCND1, CDKN3
50tyrosine437.2FYN, PTPRA, PTPN1, SRC, CCND1, CDKN3

GO Terms for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Cellular components related to Estrogen-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.8EGF, SRC, PTPN1, PTPRA, FYN

Biological processes related to Estrogen-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1mammary gland alveolus developmentGO:00607499.8EGF, CCND1
2endoplasmic reticulum unfolded protein responseGO:00309689.6CCND1, PTPN1
3forebrain developmentGO:00309009.5SRC, FYN
4T cell costimulationGO:00312959.5FYN, SRC
5Fc-gamma receptor signaling pathway involved in phagocytosisGO:00380969.4SRC, FYN
6response to ethanolGO:00454719.4CCND1, FYN
7fibroblast growth factor receptor signaling pathwayGO:00085439.3EGF, SRC, FYN
8peptidyl-tyrosine phosphorylationGO:00181089.2EGF, SRC
9epidermal growth factor receptor signaling pathwayGO:00071739.2FYN, SRC, EGF
10neurotrophin TRK receptor signaling pathwayGO:00480119.2EGF, SRC, FYN
11platelet activationGO:00301688.9EGF, SRC, PTPN1, FYN
12peptidyl-tyrosine dephosphorylationGO:00353358.9CDKN3, PTPN1, PTPRA
13blood coagulationGO:00075968.9FYN, PTPN1, SRC, EGF
14axon guidanceGO:00074118.8FYN, PTPRA, SRC

Molecular functions related to Estrogen-Receptor Negative Breast Cancer according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1growth factor receptor bindingGO:00708519.5SRC, FYN
2protein tyrosine kinase activityGO:00047139.4SRC, FYN
3non-membrane spanning protein tyrosine kinase activityGO:00047159.3SRC, FYN
4ephrin receptor bindingGO:00468759.2SRC, PTPN1, FYN
5ion channel bindingGO:00443259.1SRC, FYN
6protein tyrosine phosphatase activityGO:00047258.7PTPRA, PTPN1, CDKN3
7protein bindingGO:00055156.7FYN, PTPRA, PTPN1, SRC, CCND1, CDKN3

Products for genes affiliated with Estrogen-Receptor Negative Breast Cancer

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Sources for Estrogen-Receptor Negative Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet