MCID: EST001
MIFTS: 36

Estrogen-Receptor Positive Breast Cancer malady

Cancer category

Summaries for Estrogen-Receptor Positive Breast Cancer

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33MalaCards
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MalaCards: Estrogen-Receptor Positive Breast Cancer is related to estrogen-receptor negative breast cancer and estrogen resistance. An important gene associated with Estrogen-Receptor Positive Breast Cancer is HSPB8 (heat shock 22kDa protein 8). The compounds estrogen and glucuronic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lymph node, and related mouse phenotype normal.

Aliases & Classifications for Estrogen-Receptor Positive Breast Cancer

Sources:
8Disease Ontology, 10DISEASES
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

estrogen-receptor positive breast cancer 8 10


External Ids:

Disease Ontology8 DOID:0060075

Related Diseases for Estrogen-Receptor Positive Breast Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Estrogen-Receptor Positive Breast Cancer:



Diseases related to estrogen-receptor positive breast cancer

Clinical Features for Estrogen-Receptor Positive Breast Cancer

Drugs & Therapeutics for Estrogen-Receptor Positive Breast Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Estrogen-Receptor Positive Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Estrogen-Receptor Positive Breast Cancer

Search NIH Clinical Center for Estrogen-Receptor Positive Breast Cancer

Search CenterWatch for Estrogen-Receptor Positive Breast Cancer

Genetic Tests for Estrogen-Receptor Positive Breast Cancer

Anatomical Context for Estrogen-Receptor Positive Breast Cancer

Sources:
33MalaCards
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MalaCards organs/tissues related to Estrogen-Receptor Positive Breast Cancer:

33
Skin, Brain, Lymph node, Thyroid, Breast, T cells, B cells, Endothelial

Animal Models for Estrogen-Receptor Positive Breast Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Estrogen-Receptor Positive Breast Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.3SPAG5, SPHK1, PLXNB1, MYB, NCOA3, HDAC6

Publications for Estrogen-Receptor Positive Breast Cancer

Sources:
51PubMed
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Articles related to Estrogen-Receptor Positive Breast Cancer:

(show top 50)    (show all 374)
idTitleAuthorsYear
1
FOXA1 expression after neoadjuvant chemotherapy is a prognostic marker in estrogen receptor-positive breast cancer. (23771556)
2013
2
Breast cancer index identifies early-stage estrogen receptor-positive breast cancer patients at risk for early- and late-distant recurrence. (23757354)
2013
3
p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors. (24118529)
2013
4
BCL-2: a new therapeutic target in estrogen receptor-positive breast cancer? (23845438)
2013
5
Prognostic discrimination using a 70-gene signature among patients with estrogen receptor-positive breast cancer and an intermediate 21-gene recurrence score. (24304542)
2013
6
Tannic Acid preferentially targets estrogen receptor-positive breast cancer. (24369505)
2013
7
Pregnancy after a diagnosis of estrogen receptor-positive breast cancer does not affect prognosis. (23463611)
2013
8
Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. (23971947)
2013
9
G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients. (23554355)
2013
10
p53, a target of estrogen receptor (ER) I+, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells. (22787161)
2012
11
Hazard of breast cancer-specific mortality among women with estrogen receptor-positive breast cancer after five years from diagnosis: implication for extended endocrine therapy. (22993034)
2012
12
Adjuvant tamoxifen reduces subsequent breast cancer in women with estrogen receptor-positive ductal carcinoma in situ: a study based on NSABP protocol B-24. (22393101)
2012
13
Mouse models of estrogen receptor-positive breast cancer. (22279420)
2011
14
Estrogen receptor-positive breast cancer in Japanese women: trends in incidence, characteristics, and prognosis. (21119029)
2011
15
Physician survey of the effect of the 21-gene recurrence score assay results on treatment recommendations for patients with lymph node-positive, estrogen receptor-positive breast cancer. (21731516)
2011
16
SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. (21771784)
2011
17
Effects of SDF-1-CXCR4 signaling on microRNA expression and tumorigenesis in estrogen receptor-alpha (ER-I+)-positive breast cancer cells. (21906588)
2011
18
Estrogen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells. (21367855)
2011
19
Estrogen receptor (ESR1) mRNA expression and benefit from tamoxifen in the treatment and prevention of estrogen receptor-positive breast cancer. (21947828)
2011
20
Risk of recurrence and chemotherapy benefit for patients with node-negative, estrogen receptor-positive breast cancer: recurrence score alone and integrated with pathologic and clinical factors. (22010013)
2011
21
Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells. (19569049)
2010
22
The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. (20086172)
2010
23
Relationship between plasma estradiol levels and estrogen-responsive gene expression in estrogen receptor-positive breast cancer in postmenopausal women. (20124184)
2010
24
High CCND1 amplification identifies a group of poor prognosis women with estrogen receptor positive breast cancer. (19904758)
2010
25
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. (20479250)
2010
26
Growth inhibition of estrogen receptor positive human breast cancer cells by Taheebo from the inner bark of Tabebuia avellandae tree. (19578798)
2009
27
PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. (19874578)
2009
28
Does breast density show difference in patients with estrogen receptor-positive and estrogen receptor-negative breast cancer measured on MRI? (19654204)
2009
29
Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer. (19552798)
2009
30
Estrogen induces estrogen-related receptor alpha gene expression and chromatin structural changes in estrogen receptor (ER)-positive and ER-negative breast cancer cells. (18174157)
2008
31
Possible difference in frequencies of genetic polymorphisms of estrogen receptor alpha, estrogen metabolism and P53 genes between estrogen receptor-positive and -negative breast cancers. (18820009)
2008
32
Arylamine N-acetyltransferase 1 expression in breast cancer cell lines: a potential marker in estrogen receptor-positive tumors. (17973251)
2008
33
Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells. (18313654)
2008
34
Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer: a phase IIb/III trial to investigate optimal duration of preoperative endocrine therapy. (18302747)
2008
35
Effect of molecular disease subsets on disease-free survival in randomized adjuvant chemotherapy trials for estrogen receptor-positive breast cancer. (18662965)
2008
36
Combined paclitaxel and cetuximab achieved a major response on the skin metastases of a patient with epidermal growth factor receptor-positive, estrogen receptor-negative, progesterone receptor-negative and human epidermal growth factor receptor-2-negative (triple-negative) breast cancer. (17581308)
2007
37
Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells. (17690249)
2007
38
Progesterone receptor in estrogen receptor-positive breast cancer: the association between HER-2 and lymph node involvement is age related. (16735717)
2006
39
Estrogen enhances the efficacy of an oncolytic HSV-1 mutant in the treatment of estrogen receptor-positive breast cancer. (16685445)
2006
40
Estrogen regulation of the glucuronidation enzyme UGT2B15 in estrogen receptor-positive breast cancer cells. (16690804)
2006
41
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. (16720680)
2006
42
Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer. (16954437)
2006
43
Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. (15806142)
2005
44
In vivo prediction of response to antiestrogen treatment in estrogen receptor-positive breast cancer. (14734659)
2004
45
Association of p53 genetic polymorphism (Arg72Pro) with estrogen receptor positive breast cancer risk in Japanese women. (15183535)
2004
46
Combined vascular endothelial growth factor and TP53 status predicts poor response to tamoxifen therapy in estrogen receptor-positive advanced breast cancer. (12684392)
2003
47
Involvement of G1/S cyclins in estrogen-independent proliferation of estrogen receptor-positive breast cancer cells. (12444551)
2002
48
Heat shock proteins hsp27 and hsp70: lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer (a Southwest Oncology Group Study). (9607585)
1998
49
Influence of different combinations of tamoxifen and toremifene on estrogen receptor-positive breast cancer cell lines. (7553677)
1995
50
Endocrine versus endocrine plus five-drug chemotherapy in postmenopausal women with stage II estrogen receptor-positive breast cancer. (2790695)
1989

Genetic Variations for Estrogen-Receptor Positive Breast Cancer

Expression for genes affiliated with Estrogen-Receptor Positive Breast Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Estrogen-Receptor Positive Breast Cancer

Search GEO for disease gene expression data for Estrogen-Receptor Positive Breast Cancer.

Pathways for genes affiliated with Estrogen-Receptor Positive Breast Cancer

Compounds for genes affiliated with Estrogen-Receptor Positive Breast Cancer

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Estrogen-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7ARSH, ISG20
2glucuronic acid4510.7ARSH, UGT1A, UGT2B15
3dihydrotestosterone45 29 11 2413.6NCOA3, UGT2B15, UGT1A, ARSH
4steroid4510.6ARSH, UGT1A, UGT2B15, HDAC6, NCOA3, MYB
5estradiol45 11 2412.6ARSH, UGT1A, UGT2B15, NCOA3, MYB
6tamoxifen45 50 29 1113.6ARSH, UGT1A, UGT2B15, NCOA3
7tyrosine4510.6ISG20, ARSH, UGT2B15, STAT5B, HDAC6, NCOA3
8rapamycin4510.5SPHK1, MYB, NCOA3, STAT5B
9estrone45 29 11 2413.5ARSH, UGT1A, UGT2B15
10glucuronide4510.5UGT2B15, UGT1A
11daidzein4510.4UGT1A, ARSH
12flavonoid4510.4MYB, UGT1A
13adenine45 11 2412.3ISG20, UGT1A, MYB
14cotinine45 2411.1UGT2B15, UGT1A

GO Terms for genes affiliated with Estrogen-Receptor Positive Breast Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Estrogen-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.2SPAG5, HSPB8, SAGE1, ISG20, FBXL3, TOX3

Biological processes related to Estrogen-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of mitotic cell cycleGO:04593110.4SPHK1, STAT5B
2T cell homeostasisGO:04302910.1STAT5B, PMAIP1

Products for genes affiliated with Estrogen-Receptor Positive Breast Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Estrogen-Receptor Positive Breast Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet