MCID: EST001
MIFTS: 38

Estrogen-Receptor Positive Breast Cancer malady

Cancer diseases category

Summaries for Estrogen-Receptor Positive Breast Cancer

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32MalaCards
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MalaCards: Estrogen-Receptor Positive Breast Cancer is related to breast cancer and ovarian cancer. An important gene associated with Estrogen-Receptor Positive Breast Cancer is HSPB8 (heat shock 22kDa protein 8). The compounds estrogen and glucuronic acid have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and bone, and related mouse phenotype normal.

Aliases & Classifications for Estrogen-Receptor Positive Breast Cancer

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8Disease Ontology, 10DISEASES
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

estrogen-receptor positive breast cancer 8 10


External Ids:

Disease Ontology8 DOID:0060075

Related Diseases for Estrogen-Receptor Positive Breast Cancer

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17GeneCards, 18GeneDecks
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Diseases in the Estrogen-Receptor Negative Breast Cancer family:

estrogen-receptor positive breast cancer

Diseases related to Estrogen-Receptor Positive Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 22)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer32.2SPHK1, SAGE1, ISG20, ARSH, UGT1A, UGT2B15
2ovarian cancer30.8NCOA3
3estrogen-receptor negative breast cancer10.9
4lymph node cancer10.7
5progesterone-receptor positive breast cancer10.6
6estrogen excess10.4
7breast disease10.4
8cell type cancer10.4
9vascular cancer10.4
10parametritis10.3
11papillary carcinoma10.3
12sporadic breast cancer10.3
13breast papillary carcinoma10.3
14fallopian tube cancer10.3
15papillary thyroid carcinoma10.3
16thyroid cancer10.3
17thyroiditis10.3
18myeloid leukemia10.0MYB, STAT5B
19prostate cancer10.0UGT1A, UGT2B15, STAT5B, NCOA3, SPHK1
20melanoma10.0ISG20, STAT5B, MYB
21squamous cell carcinoma10.0ISG20, STAT5B, NCOA3, MYB, PLXNB1
22pancreatic cancer10.0NCOA3, ARSH

Graphical network of the top 20 diseases related to Estrogen-Receptor Positive Breast Cancer:



Diseases related to estrogen-receptor positive breast cancer

Clinical Features for Estrogen-Receptor Positive Breast Cancer

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Drugs & Therapeutics for Estrogen-Receptor Positive Breast Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Estrogen-Receptor Positive Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Estrogen-Receptor Positive Breast Cancer

Search NIH Clinical Center for Estrogen-Receptor Positive Breast Cancer

Search CenterWatch for Estrogen-Receptor Positive Breast Cancer

Genetic Tests for Estrogen-Receptor Positive Breast Cancer

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Anatomical Context for Estrogen-Receptor Positive Breast Cancer

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32MalaCards
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MalaCards organs/tissues related to Estrogen-Receptor Positive Breast Cancer:

32
Breast, Lymph node, Bone, Endothelial, Testes, Thyroid, Skin, T cells

Animal Models for Estrogen-Receptor Positive Breast Cancer or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Estrogen-Receptor Positive Breast Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.3SPAG5, SPHK1, PLXNB1, MYB, NCOA3, HDAC6

Publications for Estrogen-Receptor Positive Breast Cancer

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50PubMed
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Articles related to Estrogen-Receptor Positive Breast Cancer:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Significance of TP53 mutations determined by next-generation "deep" sequencing in prognosis of estrogen receptor-positive breast cancer. (23973262)
2014
2
Association of tissue inhibitor of metalloproteinases-1 and Ki67 in estrogen receptor positive breast cancer. (23205744)
2013
3
The financial burden of using Oncotype Dx for patients with lymph node-negative and estrogen receptor-positive breast cancer in Australia. (23718901)
2013
4
Metastasis dormancy in estrogen receptor-positive breast cancer. (24298069)
2013
5
A Common Variant in the SIAH2 Locus Is Associated with Estrogen Receptor-Positive Breast Cancer in the Chinese Han Population. (24244489)
2013
6
Functional variable number of tandem repeats variation in the promoter of proto-oncogene PTTG1IP is associated with risk of estrogen receptor-positive breast cancer. (22404099)
2012
7
Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients. (21796367)
2012
8
9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium. (22859399)
2012
9
Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids. (23142364)
2012
10
Polyendocrine treatment in estrogen receptor-positive breast cancer: a "FACT" yet to be proven. (22547606)
2012
11
Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells. (22216287)
2011
12
Bisphosphonate use after estrogen receptor-positive breast cancer and risk of contralateral breast cancer. (22021667)
2011
13
PRO_10--a new tissue-based prognostic multigene marker in patients with early estrogen receptor-positive breast cancer. (21613801)
2011
14
Let-7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer. (20535543)
2011
15
Activity of taspine isolated from Radix et Rhizoma Leonticis against estrogen-receptor-positive breast cancer. (21605638)
2011
16
Androgen receptor expression is significantly associated with better outcomes in estrogen receptor-positive breast cancers. (21310761)
2011
17
CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (A+)-14,15-epoxyeicosatrienoic acid (EET). (21402692)
2011
18
Shift in cytotoxic target from estrogen receptor-positive to estrogen receptor-negative breast cancer cells by trastuzumab in combination with taxane-based chemotherapy. (22866081)
2011
19
Estrogen regulated expression of the p21 Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells. (20301197)
2010
20
Prognostic value of estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 in node positive breast cancer patients treated by mastectomy]. (21029696)
2010
21
Microarray data analysis in neoadjuvant biomarker studies in estrogen receptor-positive breast cancer. (20804563)
2010
22
Vascular endothelial growth factor secreted by activated stroma enhances angiogenesis and hormone-independent growth of estrogen receptor-positive breast cancer. (20332242)
2010
23
A study of the effects of the aromatase inhibitors anastrozole and letrozole on bone metabolism in postmenopausal women with estrogen receptor-positive breast cancer. (19941160)
2010
24
Gene expression of topoisomerase II alpha (TOP2A) by microarray analysis is highly prognostic in estrogen receptor (ER) positive breast cancer. (18340528)
2009
25
Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042. (19567422)
2009
26
Positive cross-talk between estrogen receptor and NF-kappaB in breast cancer. (19920189)
2009
27
Androgen-induced human breast cancer cell proliferation is mediated by discrete mechanisms in estrogen receptor-alpha-positive and -negative breast cancer cells. (19159686)
2009
28
Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines. (19171042)
2009
29
A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study. (18771580)
2008
30
Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics. (18812550)
2008
31
Low phosphorylation of estrogen receptor alpha (ERalpha) serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast cancer. (18550720)
2008
32
Tamoxifen induces heparanase expression in estrogen receptor-positive breast cancer. (17634531)
2007
33
Estrogen receptor alpha (ER alpha) mRNA copy numbers in immunohistochemically ER alpha-positive-, and negative breast cancer tissues. (17391528)
2007
34
An integrated analysis of genes and pathways exhibiting metabolic differences between estrogen receptor positive breast cancer cells. (17883861)
2007
35
Human epidermal growth factor receptor 2 status correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cytotoxic chemotherapy. (17906205)
2007
36
Estrogen receptor-beta: why may it influence clinical outcome in estrogen receptor-alpha positive breast cancer? (17617929)
2007
37
PARP regulates TGF-beta receptor type II expression in estrogen receptor-positive breast cancer cell lines. (16827122)
2006
38
The antitumor effect of LJ-529, a novel agonist to A3 adenosine receptor, in both estrogen receptor-positive and estrogen receptor-negative human breast cancers. (16546983)
2006
39
Is anthracycline-based chemotherapy alone adequate for young women with estrogen receptor-positive breast cancer? (16131469)
2006
40
Novel prognostic immunohistochemical biomarker panel for estrogen receptor-positive breast cancer. (16809728)
2006
41
Research review: Treatment of breast cancer with tamoxifen in older women with estrogen receptor-positive breast cancer: motivational issues. (15592256)
2004
42
HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a southwest oncology group study. (15355892)
2004
43
Heterogeneic expression of estrogen receptor between the primary tumor and the corresponding involved lymph nodes in patients with node-positive breast cancer and its implications in patient outcome. (12772201)
2003
44
Modulation of epidermal growth factor receptor in endocrine-resistant, estrogen-receptor-positive breast cancer. (12095935)
2002
45
The role of Stat5 in estrogen receptor-positive breast cancer. (12459712)
2002
46
A therapeutic target for hormone-independent estrogen receptor-positive breast cancers. (11474128)
2001
47
Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial. (11559718)
2001
48
Cyclin D1 and estrogen receptor messenger RNA levels are positively correlated in primary breast cancer. (9816251)
1996
49
Estrogen receptor gene analysis in estrogen receptor-positive and receptor-negative primary breast cancer. (7861463)
1995
50
Protein kinase C subspecies in estrogen receptor-positive and -negative human breast cancer cell lines. (2222428)
1990

Genetic Variations for Estrogen-Receptor Positive Breast Cancer

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Expression for genes affiliated with Estrogen-Receptor Positive Breast Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Estrogen-Receptor Positive Breast Cancer

Search GEO for disease gene expression data for Estrogen-Receptor Positive Breast Cancer.

Pathways for genes affiliated with Estrogen-Receptor Positive Breast Cancer

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Compounds for genes affiliated with Estrogen-Receptor Positive Breast Cancer

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Estrogen-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7ARSH, ISG20
2glucuronic acid4410.7ARSH, UGT1A, UGT2B15
3dihydrotestosterone44 28 11 2413.6NCOA3, UGT2B15, UGT1A, ARSH
4steroid4410.6ARSH, UGT1A, UGT2B15, HDAC6, NCOA3, MYB
5estradiol44 11 2412.6ARSH, UGT1A, UGT2B15, NCOA3, MYB
6tamoxifen44 49 28 1113.6ARSH, UGT1A, UGT2B15, NCOA3
7tyrosine4410.6ISG20, ARSH, UGT2B15, STAT5B, HDAC6, NCOA3
8rapamycin4410.5SPHK1, MYB, NCOA3, STAT5B
9estrone44 28 11 2413.5ARSH, UGT1A, UGT2B15
10glucuronide4410.5UGT2B15, UGT1A
11daidzein4410.4UGT1A, ARSH
12flavonoid4410.4MYB, UGT1A
13adenine44 11 2412.3ISG20, UGT1A, MYB
14cotinine44 2411.1UGT2B15, UGT1A

GO Terms for genes affiliated with Estrogen-Receptor Positive Breast Cancer

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16Gene Ontology
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Cellular components related to Estrogen-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.2SPAG5, HSPB8, SAGE1, ISG20, FBXL3, TOX3

Biological processes related to Estrogen-Receptor Positive Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of mitotic cell cycleGO:04593110.4SPHK1, STAT5B
2T cell homeostasisGO:04302910.1STAT5B, PMAIP1

Products for genes affiliated with Estrogen-Receptor Positive Breast Cancer

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Sources for Estrogen-Receptor Positive Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet