MCID: ETH001
MIFTS: 38

Ethmoid Sinus Adenocarcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Ethmoid Sinus Adenocarcinoma

MalaCards integrated aliases for Ethmoid Sinus Adenocarcinoma:

Name: Ethmoid Sinus Adenocarcinoma 12 14 69
Adenocarcinoma of the Ethmoid Sinus 12
Adenocarcinoma of Ethmoid Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2766
NCIt 46 C6237
UMLS 69 C1333472

Summaries for Ethmoid Sinus Adenocarcinoma

Disease Ontology : 12 An ethmoid sinus cancer that derives from epithelial cells of glandular origin.

MalaCards based summary : Ethmoid Sinus Adenocarcinoma, also known as adenocarcinoma of the ethmoid sinus, is related to adenocarcinoma and esophagus squamous cell carcinoma, and has symptoms including rhinorrhea and pain. An important gene associated with Ethmoid Sinus Adenocarcinoma is CTTN (Cortactin), and among its related pathways/superpathways are Focal Adhesion and CCR5 Pathway in Macrophages. The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Ethmoid Sinus Adenocarcinoma

Diseases related to Ethmoid Sinus Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 29.3 CCND1 EGFR HRAS
2 esophagus squamous cell carcinoma 10.3 CCND1 CTTN
3 hemimegalencephaly 10.2 CCND1 PIK3CA
4 apocrine adenoma 10.2 HRAS PIK3CA
5 squamous cell carcinoma of the oral tongue 10.2 CCND1 PIK3CA
6 aggressive digital papillary adenocarcinoma 10.2 HRAS PIK3CA
7 nevus, epidermal 10.1 HRAS PIK3CA
8 tumor suppressor gene on chromosome 11 10.1 EGFR PIK3CA
9 nasal cavity adenocarcinoma 10.1 CXCL11 HRAS
10 paronychia 10.0 EGFR HRAS
11 salivary gland adenoid cystic carcinoma 9.9 CCND1 CTTN HRAS
12 spinal chordoma 9.9 EGFR PIK3CA
13 cyclosporiasis 9.9 GGT1 GGT2
14 hidradenocarcinoma 9.9 CCND1 EGFR
15 retinal detachment 9.9
16 retinitis 9.9
17 algoneurodystrophy 9.9 GGT1 GGT2
18 estrogen-receptor positive breast cancer 9.8 CCND1 EGFR PIK3CA
19 thyroid cancer, nonmedullary, 1 9.8 CCND1 HRAS PIK3CA
20 lung adenoid cystic carcinoma 9.8 EGFR HRAS PIK3CA
21 acneiform dermatitis 9.8 EGFR HRAS PIK3CA
22 hepatic tuberculosis 9.8 GGT1 GGT2
23 adenosquamous cell lung carcinoma 9.8 EGFR HRAS PIK3CA
24 uterine carcinosarcoma 9.8 EGFR HRAS PIK3CA
25 ovarian cancer 1 9.8 EGFR HRAS PIK3CA
26 lung squamous cell carcinoma 9.7 EGFR HRAS PIK3CA
27 cataract 31, multiple types 9.7 GGT1 GGT2
28 pre-malignant neoplasm 9.7 CCND1 EGFR
29 penile cancer 9.7 CCND1 EGFR HRAS
30 pancreatic cystadenocarcinoma 9.7 GGT1 GGT2
31 cell type cancer 9.7 CCND1 EGFR HRAS
32 granulomatous hepatitis 9.6 GGT1 GGT2
33 periampullary adenoma 9.5 GGT1 GGT2 HRAS
34 colloid carcinoma of the pancreas 9.5 GGT1 GGT2 HRAS
35 oral squamous cell carcinoma 9.5 CCND1 CTTN EGFR HRAS
36 female reproductive organ cancer 9.5 CCND1 EGFR HRAS PIK3CA
37 gastrointestinal system cancer 9.5 CCND1 EGFR HRAS PIK3CA
38 squamous cell carcinoma 9.4 CCND1 CTTN EGFR HRAS
39 lung cancer susceptibility 3 9.4 CCND1 EGFR HRAS PIK3CA
40 glioblastoma multiforme 9.4 CCND1 EGFR HRAS PIK3CA
41 glioblastoma 9.4 CCND1 EGFR HRAS PIK3CA
42 nasopharyngeal carcinoma 9.4 CCND1 EGFR HRAS PIK3CA
43 esophageal cancer 9.4 CCND1 EGFR HRAS PIK3CA
44 endometrial cancer 9.3 CCND1 EGFR HRAS PIK3CA
45 squamous cell carcinoma, head and neck 9.2 CCND1 CTTN EGFR HRAS PIK3CA
46 pancreatic cancer 9.0 CCND1 EGFR GGT1 HRAS PIK3CA
47 hepatocellular carcinoma 8.8 CCND1 CTTN EGFR GGT1 HRAS PIK3CA
48 ethmoid sinus cancer 7.4 CCND1 CTTN CXCL11 EGFR GGT1 GGT2

Graphical network of the top 20 diseases related to Ethmoid Sinus Adenocarcinoma:



Diseases related to Ethmoid Sinus Adenocarcinoma

Symptoms & Phenotypes for Ethmoid Sinus Adenocarcinoma

UMLS symptoms related to Ethmoid Sinus Adenocarcinoma:


rhinorrhea, pain

GenomeRNAi Phenotypes related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.36 EGFR HRAS PIK3CA
2 Decreased viability GR00221-A-1 9.36 EGFR HRAS PIK3CA
3 Decreased viability GR00221-A-2 9.36 HRAS PIK3CA
4 Decreased viability GR00221-A-3 9.36 HRAS
5 Decreased viability GR00221-A-4 9.36 EGFR PIK3CA

MGI Mouse Phenotypes related to Ethmoid Sinus Adenocarcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 CCND1 CTTN EGFR HRAS NDUFS3 PIK3CA
2 growth/size/body region MP:0005378 9.92 CCND1 CTTN EGFR GGT1 HRAS NDUFS3
3 endocrine/exocrine gland MP:0005379 9.85 CCND1 EGFR GGT1 HRAS PIK3CA SNCA
4 integument MP:0010771 9.73 CCND1 EGFR GGT1 HRAS PIK3CA SNCA
5 no phenotypic analysis MP:0003012 9.55 CTTN EGFR HRAS PIK3CA SNCA
6 reproductive system MP:0005389 9.43 CCND1 CTTN EGFR GGT1 PIK3CA SNCA
7 skeleton MP:0005390 9.1 GGT1 HRAS PIK3CA SNCA CCND1 EGFR

Drugs & Therapeutics for Ethmoid Sinus Adenocarcinoma

Drugs for Ethmoid Sinus Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mechanisms of Cancerogenesis of Woodworkers Adenocarcinomas Completed NCT02818231

Search NIH Clinical Center for Ethmoid Sinus Adenocarcinoma

Genetic Tests for Ethmoid Sinus Adenocarcinoma

Anatomical Context for Ethmoid Sinus Adenocarcinoma

MalaCards organs/tissues related to Ethmoid Sinus Adenocarcinoma:

38
Liver

Publications for Ethmoid Sinus Adenocarcinoma

Articles related to Ethmoid Sinus Adenocarcinoma:

# Title Authors Year
1
Liver metastasis of ethmoid sinus adenocarcinoma. ( 25577139 )
2015
2
Advanced ethmoid sinus adenocarcinoma presenting as temporary exudative retinal detachment. ( 23898291 )
2013
3
Leptomeningeal carcinomatosis from ethmoid sinus adenocarcinoma. ( 23273418 )
2012
4
Survival for ethmoid sinus adenocarcinoma in European populations. ( 19363711 )
2009
5
Amplification of CCND1, EMS1, PIK3CA, and ERBB oncogenes in ethmoid sinus adenocarcinomas. ( 16815198 )
2006
6
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications. ( 10421261 )
1999
7
Leptomeningeal metastases from ethmoid sinus adenocarcinoma: clinico-radiological correlation. ( 10670169 )
1999
8
Cisplatin-based neoadjuvant chemotherapy and combined resection for ethmoid sinus adenocarcinoma reaching and/or invading the skull base. ( 8663951 )
1996
9
Orbital presentation of ethmoid sinus adenocarcinoma. ( 8751129 )
1995
10
Ethmoid sinus adenocarcinoma metastatic to breast. ( 7311554 )
1981

Variations for Ethmoid Sinus Adenocarcinoma

Expression for Ethmoid Sinus Adenocarcinoma

Search GEO for disease gene expression data for Ethmoid Sinus Adenocarcinoma.

Pathways for Ethmoid Sinus Adenocarcinoma

Pathways related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 CCND1 EGFR HRAS PIK3CA
2
Show member pathways
12.74 CCND1 CXCL11 HRAS PIK3CA
3 12.7 CCND1 EGFR HRAS PIK3CA
4
Show member pathways
12.61 CCND1 EGFR HRAS PIK3CA
5
Show member pathways
12.5 CCND1 EGFR HRAS PIK3CA
6
Show member pathways
12.39 CCND1 EGFR HRAS PIK3CA
7
Show member pathways
12.38 EGFR HRAS PIK3CA
8 12.32 CCND1 EGFR HRAS PIK3CA
9
Show member pathways
12.27 CCND1 EGFR HRAS PIK3CA
10
Show member pathways
12.21 CCND1 HRAS PIK3CA
11
Show member pathways
12.2 EGFR HRAS PIK3CA
12 12.17 CCND1 HRAS PIK3CA
13
Show member pathways
12.11 CCND1 EGFR HRAS PIK3CA
14
Show member pathways
12.08 CCND1 EGFR HRAS PIK3CA
15 12.04 CCND1 HRAS PIK3CA
16
Show member pathways
12.02 CCND1 EGFR HRAS PIK3CA
17
Show member pathways
12.01 EGFR HRAS PIK3CA
18
Show member pathways
11.92 CCND1 EGFR HRAS
19 11.92 EGFR HRAS PIK3CA
20
Show member pathways
11.89 CCND1 EGFR HRAS PIK3CA
21 11.85 CCND1 HRAS PIK3CA
22 11.84 CCND1 HRAS PIK3CA
23 11.81 CCND1 EGFR HRAS
24
Show member pathways
11.79 EGFR HRAS PIK3CA
25
Show member pathways
11.79 CCND1 EGFR HRAS PIK3CA
26 11.75 CCND1 HRAS PIK3CA
27 11.72 EGFR HRAS PIK3CA
28
Show member pathways
11.7 EGFR HRAS PIK3CA
29
Show member pathways
11.6 CCND1 EGFR HRAS PIK3CA
30 11.55 CCND1 EGFR HRAS
31 11.48 EGFR HRAS PIK3CA
32 11.4 CTTN EGFR HRAS
33 11.33 CCND1 CTTN EGFR HRAS PIK3CA
34 11.24 CXCL11 PIK3CA
35 11.24 EGFR PIK3CA
36 11.23 CTTN PIK3CA
37 11.21 CCND1 PIK3CA
38 11.18 EGFR HRAS
39 11.17 HRAS PIK3CA
40 11.13 HRAS PIK3CA
41 11.11 EGFR PIK3CA
42
Show member pathways
11.09 EGFR HRAS
43 11.07 EGFR PIK3CA
44 11.06 CCND1 CTTN PIK3CA
45 11.05 GGT1 GGT2
46 11.03 GGT1 GGT2
47 11.02 CCND1 HRAS
48
Show member pathways
10.95 CCND1 EGFR HRAS PIK3CA
49 10.93 EGFR PIK3CA
50 10.92 EGFR HRAS PIK3CA

GO Terms for Ethmoid Sinus Adenocarcinoma

Cellular components related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.92 EGFR GGT2 HRAS SNCA

Biological processes related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.7 CCND1 EGFR HRAS
2 negative regulation of neuron apoptotic process GO:0043524 9.67 HRAS PIK3CA SNCA
3 membrane organization GO:0061024 9.65 CTTN EGFR SNCA
4 liver regeneration GO:0097421 9.55 CCND1 EGFR
5 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.54 CXCL11 SNCA
6 regulation of long-term neuronal synaptic plasticity GO:0048169 9.51 HRAS SNCA
7 liver development GO:0001889 9.5 CCND1 EGFR PIK3CA
8 response to magnesium ion GO:0032026 9.46 CCND1 SNCA
9 glutathione catabolic process GO:0006751 9.43 GGT1 GGT2
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.43 EGFR PIK3CA SNCA
11 zymogen activation GO:0031638 9.4 GGT1 GGT2
12 leukotriene D4 biosynthetic process GO:1901750 9.37 GGT1 GGT2
13 epidermal growth factor receptor signaling pathway GO:0007173 9.33 EGFR HRAS PIK3CA
14 response to UV-A GO:0070141 8.96 CCND1 EGFR
15 ERBB2 signaling pathway GO:0038128 8.8 EGFR HRAS PIK3CA

Molecular functions related to Ethmoid Sinus Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 8.62 GGT1 GGT2

Sources for Ethmoid Sinus Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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