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Euthyroid Sick Syndrome malady

Endocrine diseases category
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Summaries for Euthyroid Sick Syndrome

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65Wikipedia, 33MalaCards
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Wikipedia:65 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), non-thyroidal illness syndrome (NTIS) or... more...

MalaCards: Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to thyroiditis and hypothyroidism. An important gene associated with Euthyroid Sick Syndrome is SERPINA7 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7), and among its related pathways are Selenium Metabolism and Selenoproteins and Development Leptin signaling via JAK STAT and MAPK cascades. The compounds Thyroxine sulfate and iodide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Euthyroid Sick Syndrome

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

euthyroid sick syndrome 8 10
euthyroid sick syndromes 45 62
sick-euthyroid syndrome 8


External Ids:

Disease Ontology8 DOID:2856
MeSH35 D005067
SNOMED-CT58 237542005
ICD9CM27 790.94

Related Diseases for Euthyroid Sick Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.9TRH, POMC, SERPINA7
2hypothyroidism30.7TRH, SERPINA7, THRSP
3cushing's syndrome30.4POMC, TRH
4sepsis30.1SERPINA7, IL6, IL1B, ALB, NPPB
5diabetes mellitus30.1NPPB, ALB, IL1B, IL6, POMC, GPT
6burns10.2
7hepatitis a10.2
8acute myocardial infarction10.2
9congestive heart failure10.2
10hepatitis10.2
11myocardial infarction10.2
12spotted fever10.2
13viral hepatitis10.2
14xanthomatosis10.2
15head injury10.2
16mediterranean spotted fever10.2
17acute adrenal insufficiency10.1POMC
18hypoaldosteronism10.1POMC
19acth deficiency10.1POMC
20choledocholithiasis10.1GPT
21protein-losing enteropathy10.1ALB
22thyrotoxicosis10.1TRH, SERPINA7
23malaria10.1ALB
24thyroid hormone resistance syndrome10.1SERPINA7, TRH
25thyroid adenoma10.1SERPINA7, DIO2
26empty sella syndrome10.1POMC, TRH
27melancholia10.1POMC, TRH
28pituitary apoplexy10.1TRH, POMC
29endogenous depression10.1TRH, POMC
30diabetes insipidus10.1TRH, POMC
31craniopharyngioma10.1POMC, TRH
32amenorrhea10.1POMC, TRH
33adrenal gland hyperfunction10.1POMC, TRH
34degenerative disc disease10.1IL1B
35neuroendocrine tumor10.1POMC, TRH
36hyperprolactinemia10.1POMC, TRH
37hypopituitarism10.1TRH, POMC
38periodontal disease10.1IL6
39syndrome of inappropriate antidiuretic hormone10.1NPPB, POMC
40panic disorder10.1POMC, TRH
41goiter10.1TRH, DIO2, SERPINA7
42hyperthyroidism10.1TRH, DIO2, SERPINA7
43acute liver failure10.1ALB, GPT
44alcoholic hepatitis10.0GPT, ALB
45hepatic encephalopathy10.0GPT, ALB
46bilirubin metabolic disorder10.0GPT, ALB
47portal hypertension10.0GPT, ALB
48cholangitis10.0GPT, ALB
49kawasaki disease10.0GPT, NPPB
50pituitary adenoma10.0SERPINA7, POMC, TRH

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to euthyroid sick syndrome

Symptoms for Euthyroid Sick Syndrome

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Drugs & Therapeutics for Euthyroid Sick Syndrome

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Search NIH Clinical Center for Euthyroid Sick Syndrome

Genetic Tests for Euthyroid Sick Syndrome

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Anatomical Context for Euthyroid Sick Syndrome

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33MalaCards
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MalaCards organs/tissues related to Euthyroid Sick Syndrome:

33
Thyroid, Heart, Pituitary

Animal Models for Euthyroid Sick Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8ALB, IL1B, IL6, POMC
2MP:00053678.3POMC, DIO2, DIO1, IL6, ALB
3MP:00053797.5TRH, THRSP, POMC, DIO2, DIO1, IL6
4MP:00053766.9THRSP, POMC, DIO2, DIO1, IL6, IL1B

Publications for Euthyroid Sick Syndrome

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52PubMed
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Articles related to Euthyroid Sick Syndrome:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. (23401683)
2013
2
Therapeutic effect of low-dose thyroxin in elderly patients with refractory heart failure and euthyroid sick syndrome]. (19778808)
2009
3
Is euthyroid sick syndrome a defensive mechanism against oxidative stress? (18524495)
2008
4
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. (19007679)
2008
5
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. (17356583)
2007
6
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. (16734083)
2006
7
Euthyroid sick syndrome in trauma patients with severe inflammatory response syndrome. (16533439)
2006
8
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. (16076941)
2005
9
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? (15055468)
2003
10
Euthyroid sick syndrome in acute ischemic syndromes. (12463624)
2002
11
Euthyroid sick syndrome. (12005007)
2002
12
Euthyroid sick syndrome in children with Hodgkin disease. (11293290)
2001
13
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. (10913935)
2000
14
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. (14564609)
2000
15
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. (10930442)
2000
16
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. (11138334)
2000
17
Euthyroid sick syndrome. (17016284)
2000
18
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. (14600974)
2000
19
Changes in metabolism of TRH in euthyroid sick syndrome. (10526245)
1999
20
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. (10660848)
1999
21
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. (10094108)
1999
22
Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. (9591009)
1998
23
Euthyroid sick syndrome: recent physiopathologic findings]. (9793151)
1998
24
Role of cytokines in the pathogenesis of the euthyroid sick syndrome. (9678522)
1998
25
Euthyroid sick syndrome: an overview. (9086580)
1997
26
Transiently decreased sialylation of thyrotropin (TSH) in a patient with the euthyroid sick syndrome. (9086572)
1997
27
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. (9349590)
1997
28
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? (9024211)
1997
29
Nonthyroidal illness syndrome or euthyroid sick syndrome? (15251561)
1996
30
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. (11862240)
1996
31
Euthyroid sick syndrome in psychiatric inpatients. (8959294)
1996
32
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome. (7834406)
1995
33
Cardiopulmonary bypass temperature does not affect postoperative euthyroid sick syndrome? (7497757)
1995
34
Distinguishing hypothyroxinemia due to euthyroid sick syndrome from pituitary insufficiency. (7960686)
1994
35
Possible etiology for euthyroid sick syndrome. (8455465)
1993
36
Plasma selenium concentrations in patients with euthyroid sick syndrome. (1526030)
1992
37
Heart transplantation, euthyroid sick syndrome, and triiodothyronine replacement. (1515440)
1992
38
Triiodothyronine replacement, the euthyroid sick syndrome, and organ transplantation. (1926432)
1991
39
Euthyroid sick syndrome in children with acute viral hepatitis A. (1867890)
1991
40
The euthyroid sick syndrome. (1853787)
1991
41
Euthyroid sick syndrome in type I diabetes mellitus in children and adolescents. (1867879)
1991
42
Euthyroid sick syndrome. (3919544)
1985
43
Malignant Mediterranean spotted fever. Report of a case with multiple organ failure, hypocalcemia, and euthyroid sick syndrome. (3839356)
1985
44
Familial hyperlipidaemia with multiple xanthomatosis and euthyroid sick syndrome. (6724629)
1984
45
Euthyroid sick syndrome. Association with urosepsis in an elderly man. (6371753)
1984
46
Euthyroid sick syndrome and free thyroxine assay. (6135016)
1983
47
Frequency of euthyroid sick syndrome as assessed by free thyroxine index and a direct free thyroxine assay. A limitation of FT4 assays. (6134145)
1983
48
Euthyroid sick syndrome and free thyroxine assay. (6135900)
1983
49
Euthyroid sick syndrome. (7295055)
1981
50
Euthyroid sick syndrome. (714120)
1978

Variations for Euthyroid Sick Syndrome

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Expression for genes affiliated with Euthyroid Sick Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Euthyroid Sick Syndrome

Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for genes affiliated with Euthyroid Sick Syndrome

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome, 30KEGG, 53QIAGEN, 54R&D Systems
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Pathways related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9DIO1, DIO2
2
Show member pathways
9.6POMC, TRH
39.6IL6, IL1B
49.6IL1B, IL6
59.6IL6, IL1B
69.6IL1B, IL6
79.6IL1B, IL6
89.6IL6, IL1B
99.6IL1B, IL6
10
Show member pathways
creatine-phosphate biosynthesis38
glycine degradation (creatine biosynthesis)38
putrescine biosynthesis III38
spermidine biosynthesis I38
tryptophan degradation via kynurenine38
spermine biosynthesis38
urea cycle38
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I38
tyrosine degradation I38
L-carnitine biosynthesis38
methylthiopropionate biosynthesis38
2-oxoglutarate decarboxylation to succinyl-CoA38
S-methyl-5-thioadenosine degradation II38
9.5DIO1, DIO2, GPT
11
Show member pathways
thioredoxin pathway38
8.5ALB, IL1B, IL6, DIO1, DIO2

Compounds for genes affiliated with Euthyroid Sick Syndrome

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24HMDB, 45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 3BitterDB, 61Tocris Bioscience
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Compounds related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1Thyroxine sulfate2410.2DIO2, DIO1
2iodide45 2411.0DIO1, DIO2, SERPINA7
3muramyl tripeptide phosphatidylethanolamine459.9IL6, IL1B
4turpentine459.8IL1B, IL6
5sevoflurane51 45 1111.6GPT, NPPB, ALB
6hepaplastin459.6ALB, GPT
7pyridoxal 5-phosphate459.6POMC, GPT, ALB
8liothyronine51 24 1111.5DIO2, DIO1, SERPINA7, ALB
9iodine45 2410.5DIO2, SERPINA7, DIO1, TRH
10rosuvastatin45 51 29 1112.5GPT, ALB, IL6
11methimazole45 3 1111.5TRH, DIO2, POMC, SERPINA7
12corticosterone45 61 2411.5GPT, SERPINA7, IL1B, POMC
13pentoxifylline45 1110.4IL6, IL1B, NPPB
14spironolactone45 61 29 51 1113.4ALB, SERPINA7, POMC, NPPB
15furosemide45 61 29 51 24 1114.4SERPINA7, NPPB, ALB, POMC
16naloxone45 29 51 1112.4TRH, POMC, ALB
17neopterin459.4IL1B, IL6, GPT
18aspirin45 51 29 2412.4SERPINA7, NPPB, POMC, IL1B
19ribonucleic acid459.4IL1B, DIO2, POMC, SERPINA7
20diazepam45 29 51 1112.4ALB, TRH, POMC
21haloperidol45 51 29 3 1113.3GPT, POMC, NPPB, TRH
22pravastatin45 51 29 24 1113.3NPPB, IL6, GPT, IL1B
23ibuprofen45 29 51 24 1113.3IL6, IL1B, ALB
24rosiglitazone29 45 51 24 1113.2ALB, NPPB, IL6, GPT
25urea45 24 1111.2SERPINA7, ALB, TRH, GPT
26ivig459.2ALB, IL1B, IL6, GPT
27hydrocortisone45 3 61 1112.2IL1B, POMC, TRH, IL6
28hyaluronic acid45 2410.1GPT, IL6, ALB, IL1B
29methotrexate51 45 1111.1IL6, GPT, ALB, IL1B
30pioglitazone29 45 51 1112.0IL6, GPT, NPPB
31dopamine45 29 24 1112.0TRH, SERPINA7, NPPB, POMC, DIO2
32vitamin d459.0ALB, IL6, GPT, NPPB
33prednisolone45 29 1110.9GPT, IL6, ALB, POMC, NPPB
34acth458.9POMC, SERPINA7, IL6, TRH, IL1B
35norepinephrine45 24 1110.9IL6, POMC, TRH, NPPB
36forskolin45 51 1110.9TRH, NPPB, IL1B, DIO2, POMC
37estradiol45 24 1110.9TRH, NPPB, ALB, POMC, SERPINA7
38indomethacin45 29 61 1111.8IL6, POMC, NPPB, IL1B, ALB
39cycloheximide458.8TRH, IL1B, IL6, DIO2, POMC
40alanine458.7ALB, GPT, POMC, SERPINA7, DIO2, IL6
41creatinine458.7ALB, POMC, IL6, SERPINA7, GPT, NPPB
42arginine458.6NPPB, TRH, SERPINA7, POMC, GPT
43estrogen458.6DIO2, NPPB, POMC, TRH, IL6, SERPINA7
44histamine45 29 2410.6IL6, IL1B, NPPB, ALB
45dexamethasone45 51 29 1111.5IL6, TRH, NPPB, IL1B, DIO2, POMC
46testosterone45 61 24 1111.5SERPINA7, IL6, ALB, NPPB, TRH, POMC
47triiodothyronine458.2DIO1, DIO2, POMC, SERPINA7, THRSP, TRH
48lipid457.8THRSP, TRH, NPPB, IL6, SERPINA7, GPT
49thyroxine45 248.4THRSP, POMC, DIO2, DIO1, NPPB, TRH
50glucose457.2DIO2, TRH, ALB, IL6, POMC, SERPINA7

GO Terms for genes affiliated with Euthyroid Sick Syndrome

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16Gene Ontology
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Cellular components related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.2TRH, IL1B, POMC
2extracellular spaceGO:0056157.8SERPINA7, POMC, IL6, IL1B, ALB, NPPB
3extracellular regionGO:0055767.5TRH, SERPINA7, POMC, IL6, IL1B, ALB

Biological processes related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:04244610.1DIO1, DIO2
2thyroid hormone generationGO:00659010.1DIO1, DIO2
3response to corticosteroneGO:0514129.8SERPINA7, TRH
4positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, IL1B
5cellular nitrogen compound metabolic processGO:0346419.7DIO1, DIO2, GPT
6positive regulation of T cell proliferationGO:0421029.6IL1B, IL6
7response to coldGO:0094099.5IL6, TRH
8positive regulation of interleukin-6 productionGO:0327559.3IL1B, IL6
9cell-cell signalingGO:0072679.1TRH, IL1B, POMC

Molecular functions related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1selenium bindingGO:0084309.9DIO1, DIO2
2thyroxine 5-deiodinase activityGO:0048009.8DIO1, DIO2
3pyridoxal phosphate bindingGO:0301708.5ALB, GPT, GOT1L1

Products for genes affiliated with Euthyroid Sick Syndrome

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Sources for Euthyroid Sick Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet