MCID: ETH004
MIFTS: 40

Euthyroid Sick Syndrome malady

Summaries for Euthyroid Sick Syndrome

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), non-thyroidal illness syndrome (NTIS) or... more...

MalaCards: Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to acute myocardial infarction and cushing's syndrome. An important gene associated with Euthyroid Sick Syndrome is DIO2 (deiodinase, iodothyronine, type II), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Selenium Pathway. The compounds ivig and warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, thyroid and pituitary, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Euthyroid Sick Syndrome

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM
See all sources

Aliases & Descriptions:

euthyroid sick syndrome 8 10
euthyroid sick syndromes 45 61
sick-euthyroid syndrome 8


External Ids:

Disease Ontology8 DOID:2856
MeSH35 D005067
SNOMED-CT57 237542005
ICD9CM27 790.94

Related Diseases for Euthyroid Sick Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1acute myocardial infarction30.3NPPB
2cushing's syndrome30.3POMC, TRH
3viral hepatitis30.3GPT
4hepatitis c30.3GPT, ALB
5sepsis30.3NPPB, IL1B, IL6, SERPINA7, ALB
6n syndrome10.6
7hepatitis e10.2
8hepatitis a10.2
9spotted fever10.2
10xanthomatosis10.2
11char syndrome10.2
12head injury10.2
13multiple myeloma10.0IL6
14polyneuropathy10.0SERPINA7
15gout10.0IL1B
16interstitial lung disease10.0IL1B
17otitis media10.0IL1B
18adenocarcinoma10.0DIO2
19periodontal disease10.0IL6
20toxic shock syndrome10.0IL1B
21periodontitis10.0IL1B
22glaucoma10.0MGP
23sarcoidosis10.0IL1B
24encephalitis10.0IL1B
25thyroid cancer10.0TRH
26familial mediterranean fever10.0IL1B
27degenerative disc disease10.0IL1B
28klinefelter's syndrome10.0TRH
29respiratory failure10.0IL6, IL1B
30graves' disease10.0SERPINA7, DIO2
31anorexia nervosa10.0POMC
32brain edema10.0ALB
33dementia10.0TRH
34rheumatic fever10.0POMC
35arteriosclerosis10.0MGP
36thrombocytosis10.0IL6, IL1B
37diarrhea10.0ALB
38growth hormone deficiency10.0POMC
39polycystic ovary syndrome10.0POMC
40hyperhomocysteinemia10.0ALB
41poems syndrome10.0IL1B, IL6
42uremia10.0ALB
43rheumatoid arthritis10.0IL6, IL1B
44acute adrenal insufficiency10.0POMC
45varicose veins10.0ALB
46ovarian hyperstimulation syndrome10.0ALB
47thyroid adenoma10.0DIO2, SERPINA7
48osteoarthritis10.0IL6, IL1B
49hyperuricemia10.0GPT
50neutropenia10.0GPT

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to euthyroid sick syndrome

Clinical Features for Euthyroid Sick Syndrome

Drugs & Therapeutics for Euthyroid Sick Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Euthyroid Sick Syndrome

Drug clinical trials:

Search ClinicalTrials for Euthyroid Sick Syndrome

Search NIH Clinical Center for Euthyroid Sick Syndrome

Search CenterWatch for Euthyroid Sick Syndrome

Genetic Tests for Euthyroid Sick Syndrome

Anatomical Context for Euthyroid Sick Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Euthyroid Sick Syndrome:

33
Heart, Thyroid, Pituitary

Animal Models for Euthyroid Sick Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9DIO1, DIO2, MGP, POMC
2MP:00020068.7ALB, IL6, IL1B, FRK, POMC
3MP:00053766.9ALB, DIO1, DIO2, TRH, POMC, FRK

Publications for Euthyroid Sick Syndrome

Sources:
51PubMed
See all sources

Articles related to Euthyroid Sick Syndrome:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. (23401683)
2013
2
Euthyroid sick syndrome and nutritional status are correlated with hyposelenemia in hemodialysis patients. (21786251)
2011
3
Therapeutic effect of low-dose thyroxin in elderly patients with refractory heart failure and euthyroid sick syndrome]. (19778808)
2009
4
Is euthyroid sick syndrome a defensive mechanism against oxidative stress? (18524495)
2008
5
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. (19007679)
2008
6
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. (17356583)
2007
7
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. (16734083)
2006
8
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. (16076941)
2005
9
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? (15055468)
2003
10
Euthyroid sick syndrome in acute ischemic syndromes. (12463624)
2002
11
Euthyroid sick syndrome. (12005007)
2002
12
Interferon-gamma administration does not affect human thyroid hormone metabolism in the post-surgical euthyroid sick syndrome. (12030601)
2002
13
Euthyroid sick syndrome in children with Hodgkin disease. (11293290)
2001
14
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. (10913935)
2000
15
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. (14564609)
2000
16
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. (10930442)
2000
17
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. (11138334)
2000
18
Euthyroid sick syndrome. (17016284)
2000
19
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. (14600974)
2000
20
Euthyroid Sick Syndrome and the role of cytokines. (11704991)
2000
21
Changes in metabolism of TRH in euthyroid sick syndrome. (10526245)
1999
22
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. (10660848)
1999
23
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. (10094108)
1999
24
Euthyroid sick syndrome: recent physiopathologic findings]. (9793151)
1998
25
Role of cytokines in the pathogenesis of the euthyroid sick syndrome. (9678522)
1998
26
Euthyroid sick syndrome: an overview. (9086580)
1997
27
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. (9349590)
1997
28
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? (9024211)
1997
29
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. (11862240)
1996
30
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome. (7834406)
1995
31
Cardiopulmonary bypass temperature does not affect postoperative euthyroid sick syndrome? (7497757)
1995
32
Reverse T3 does not reliably differentiate hypothyroid sick syndrome from euthyroid sick syndrome. (8808092)
1995
33
Possible etiology for euthyroid sick syndrome. (8455465)
1993
34
Plasma selenium concentrations in patients with euthyroid sick syndrome. (1526030)
1992
35
Heart transplantation, euthyroid sick syndrome, and triiodothyronine replacement. (1515440)
1992
36
Triiodothyronine replacement, the euthyroid sick syndrome, and organ transplantation. (1926432)
1991
37
Cardiopulmonary bypass and thyroid function: a "euthyroid sick syndrome". (2069461)
1991
38
The euthyroid sick syndrome. (1853787)
1991
39
Euthyroid sick syndrome in type I diabetes mellitus in children and adolescents. (1867879)
1991
40
The euthyroid sick syndrome. (1776598)
1991
41
TSH secretion in Cushing's syndrome: relation to glucocorticoid excess, diabetes, goitre, and the 'sick euthyroid syndrome'. (2128925)
1990
42
Euthyroid sick syndrome. (3919544)
1985
43
Malignant Mediterranean spotted fever. Report of a case with multiple organ failure, hypocalcemia, and euthyroid sick syndrome. (3839356)
1985
44
Familial hyperlipidaemia with multiple xanthomatosis and euthyroid sick syndrome. (6724629)
1984
45
Euthyroid sick syndrome. Association with urosepsis in an elderly man. (6371753)
1984
46
Euthyroid sick syndrome and free thyroxine assay. (6135016)
1983
47
Frequency of euthyroid sick syndrome as assessed by free thyroxine index and a direct free thyroxine assay. A limitation of FT4 assays. (6134145)
1983
48
Euthyroid sick syndrome and free thyroxine assay. (6135900)
1983
49
Euthyroid sick syndrome and free thyroxine assay. (6137682)
1983
50
Euthyroid sick syndrome. (714120)
1978

Genetic Variations for Euthyroid Sick Syndrome

Expression for genes affiliated with Euthyroid Sick Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Euthyroid Sick Syndrome

Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for genes affiliated with Euthyroid Sick Syndrome

Sources:
53R&D Systems, 38NCBI BioSystems Database
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Pathways related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL6, IL1B
28.9ALB, IL6, IL1B, DIO2, DIO1

Compounds for genes affiliated with Euthyroid Sick Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
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Compounds related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1ivig4510.5GPT
2warfarin45 50 11 2413.4MGP
3muramyl tripeptide phosphatidylethanolamine4510.3IL1B, IL6
4turpentine4510.3IL6, IL1B
5pentoxifylline45 1111.2NPPB
6prednisolone45 29 1112.1POMC, NPPB
7forskolin45 50 1112.0POMC, NPPB
8iodide45 2411.0DIO1, SERPINA7, DIO2
9cycloheximide4510.0DIO2, TRH
10neopterin459.7IL6, GPT, IL1B
11bucillamine459.7IL6, IL1B
12rosuvastatin45 50 29 1112.6IL6, GPT, ALB
13hepaplastin459.6GPT, ALB
14ibuprofen45 29 50 11 2413.6IL6, ALB, IL1B
15corticosterone45 60 2411.6SERPINA7, IL1B, POMC, GPT
16Liothyronine11 2410.6DIO1, ALB, SERPINA7, DIO2
17iodine45 2410.6DIO2, TRH, SERPINA7, DIO1
18sevoflurane45 1110.5GPT, NPPB, ALB
19methimazole45 2 1111.5SERPINA7, POMC, TRH, DIO2
20pyridoxal 5-phosphate459.5POMC, ALB, GPT
21vitamin d459.5MGP, NPPB, IL6, GPT
22ribonucleic acid459.5POMC, IL1B, DIO2, SERPINA7
23hydrocortisone45 2 60 1112.5POMC, TRH, IL6, IL1B
24calcitriol45 60 11 2412.5ALB, IL6, IL1B, MGP
25hyaluronic acid45 2410.4ALB, IL1B, IL6, GPT
26aspirin45 50 29 2412.4NPPB, POMC, IL1B, SERPINA7
27naloxone45 50 29 1112.4ALB, POMC, TRH
28pioglitazone45 50 29 1112.4GPT, IL6, NPPB
29pravastatin45 50 29 11 2413.4GPT, NPPB, IL6
30diazepam45 50 29 1112.3POMC, ALB, TRH
31spironolactone50 45 60 29 1113.3NPPB, POMC, SERPINA7, ALB
32methotrexate45 50 1111.3GPT, IL6, IL1B, ALB
33furosemide45 50 60 29 11 2414.3NPPB, POMC, SERPINA7, ALB
34rosiglitazone45 50 29 11 2413.2NPPB, GPT, ALB, IL6
35acth459.2POMC, IL1B, IL6, TRH, SERPINA7
36urea45 11 2411.1GPT, SERPINA7, ALB, TRH
37haloperidol45 29 2 50 1113.1NPPB, TRH, POMC, GPT
38indomethacin45 60 29 1112.0ALB, POMC, NPPB, IL6, IL1B
39dopamine45 29 11 2411.9TRH, NPPB, DIO2, POMC, SERPINA7
40dexamethasone45 50 29 1111.7IL6, TRH, IL1B, POMC, DIO2, NPPB
41alanine458.7POMC, DIO2, ALB, SERPINA7, GPT, IL6
42estradiol45 11 2410.7ALB, SERPINA7, POMC, NPPB, TRH
43cholesterol45 29 11 2411.6SERPINA7, IL6, ALB, GPT, MGP
44creatinine458.6ALB, SERPINA7, GPT, NPPB, POMC, IL6
45testosterone45 60 11 2411.5TRH, SERPINA7, IL6, POMC, NPPB, ALB
46estrogen458.5NPPB, DIO2, MGP, TRH, POMC, IL6
47triiodothyronine458.1DIO2, DIO1, SERPINA7, POMC, NPPB, THRSP
48lipid457.8THRSP, SERPINA7, IL6, GPT, ALB, NPPB
49glucose457.2POMC, IL6, THRSP, ALB, TRH, DIO2
50thyroxine45 248.2TRH, DIO2, NPPB, GPT, THRSP, SERPINA7

GO Terms for genes affiliated with Euthyroid Sick Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.3IL1B, POMC, TRH
2extracellular spaceGO:0056158.2ALB, SERPINA7, IL6, IL1B, POMC, NPPB
3extracellular regionGO:0055767.5NPPB, TRH, POMC, IL1B, IL6, SERPINA7

Biological processes related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.8DIO2, DIO1
2response to corticosterone stimulusGO:0514129.7SERPINA7, TRH
3thyroid hormone generationGO:0065909.6DIO2, DIO1

Molecular functions related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1selenium bindingGO:0084309.9DIO2, DIO1
2thyroxine 5-deiodinase activityGO:0048009.8DIO2, DIO1
3pyridoxal phosphate bindingGO:0301708.4ALB, GOT1L1, GPT

Products for genes affiliated with Euthyroid Sick Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Euthyroid Sick Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet