MCID: ETH004
MIFTS: 47

Euthyroid Sick Syndrome malady

Endocrine diseases category
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Summaries for Euthyroid Sick Syndrome

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Wikipedia:65 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), non-thyroidal illness syndrome (NTIS) or... more...

MalaCards based summary: Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to thyroiditis and hypothyroidism. An important gene associated with Euthyroid Sick Syndrome is SERPINA7 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7), and among its related pathways are Selenium Metabolism and Selenoproteins and Development Leptin signaling via JAK STAT and MAPK cascades. The compounds Thyroxine sulfate and iodide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Euthyroid Sick Syndrome

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Euthyroid Sick Syndrome, Aliases & Descriptions:

Name: Euthyroid Sick Syndrome 8 10
Euthyroid Sick Syndromes 44 62
 
Sick-Euthyroid Syndrome 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:2856
MeSH34 D005067
SNOMED-CT57 237542005
ICD9CM27 790.94

Related Diseases for Euthyroid Sick Syndrome

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Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.2TRH, POMC, SERPINA7
2hypothyroidism31.0TRH, SERPINA7, THRSP
3cushing's syndrome30.8POMC, TRH
4sepsis29.6SERPINA7, IL6, IL1B, ALB, NPPB
5diabetes mellitus29.2NPPB, ALB, IL1B, IL6, POMC, GPT
6acute adrenal insufficiency10.5POMC
7hypoaldosteronism10.5POMC
8acth deficiency10.5POMC
9choledocholithiasis10.5GPT
10protein-losing enteropathy10.4ALB
11thyrotoxicosis10.4TRH, SERPINA7
12thyroid hormone resistance syndrome10.4SERPINA7, TRH
13malaria10.4ALB
14empty sella syndrome10.3POMC, TRH
15thyroid adenoma10.3SERPINA7, DIO2
16melancholia10.3POMC, TRH
17pituitary apoplexy10.3TRH, POMC
18endogenous depression10.3TRH, POMC
19diabetes insipidus10.3TRH, POMC
20craniopharyngioma10.3POMC, TRH
21amenorrhea10.3POMC, TRH
22degenerative disc disease10.3IL1B
23adrenal gland hyperfunction10.3POMC, TRH
24neuroendocrine tumor10.3POMC, TRH
25hyperprolactinemia10.3POMC, TRH
26periodontal disease10.3IL6
27hypopituitarism10.3TRH, POMC
28syndrome of inappropriate antidiuretic hormone10.3NPPB, POMC
29goiter10.2TRH, DIO2, SERPINA7
30panic disorder10.2POMC, TRH
31hyperthyroidism10.2TRH, DIO2, SERPINA7
32acute myocardial infarction10.2
33burns10.2
34congestive heart failure10.2
35hepatitis10.2
36myocardial infarction10.2
37hepatitis a10.2
38nephrotic syndrome10.2
39spotted fever10.2
40viral hepatitis10.2
41xanthomatosis10.2
42head injury10.2
43mediterranean spotted fever10.2
44acute liver failure10.2ALB, GPT
45alcoholic hepatitis10.2GPT, ALB
46hepatic encephalopathy10.2GPT, ALB
47bilirubin metabolic disorder10.2GPT, ALB
48portal hypertension10.2GPT, ALB
49cholangitis10.2GPT, ALB
50kawasaki disease10.2GPT, NPPB

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to euthyroid sick syndrome

Symptoms for Euthyroid Sick Syndrome

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Drugs & Therapeutics for Euthyroid Sick Syndrome

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Drug clinical trials:

Search ClinicalTrials for Euthyroid Sick Syndrome

Search NIH Clinical Center for Euthyroid Sick Syndrome

Genetic Tests for Euthyroid Sick Syndrome

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Anatomical Context for Euthyroid Sick Syndrome

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MalaCards organs/tissues related to Euthyroid Sick Syndrome:

32
Thyroid, Heart, Pituitary

Animal Models for Euthyroid Sick Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8ALB, IL1B, IL6, POMC
2MP:00053678.3POMC, DIO2, DIO1, IL6, ALB
3MP:00053797.5TRH, THRSP, POMC, DIO2, DIO1, IL6
4MP:00053766.9THRSP, POMC, DIO2, DIO1, IL6, IL1B

Publications for Euthyroid Sick Syndrome

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Articles related to Euthyroid Sick Syndrome:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis. (25154407)
2014
2
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. (23401683)
2013
3
Therapeutic effect of low-dose thyroxin in elderly patients with refractory heart failure and euthyroid sick syndrome]. (19778808)
2009
4
Is euthyroid sick syndrome a defensive mechanism against oxidative stress? (18524495)
2008
5
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. (19007679)
2008
6
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. (17356583)
2007
7
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. (16734083)
2006
8
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. (16076941)
2005
9
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? (15055468)
2003
10
Euthyroid sick syndrome in acute ischemic syndromes. (12463624)
2002
11
Euthyroid sick syndrome. (12005007)
2002
12
Euthyroid sick syndrome in children with Hodgkin disease. (11293290)
2001
13
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. (10913935)
2000
14
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. (14564609)
2000
15
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. (10930442)
2000
16
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. (11138334)
2000
17
Euthyroid sick syndrome. (17016284)
2000
18
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. (14600974)
2000
19
Changes in metabolism of TRH in euthyroid sick syndrome. (10526245)
1999
20
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. (10660848)
1999
21
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. (10094108)
1999
22
Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. (9591009)
1998
23
Euthyroid sick syndrome: recent physiopathologic findings]. (9793151)
1998
24
Role of cytokines in the pathogenesis of the euthyroid sick syndrome. (9678522)
1998
25
Euthyroid sick syndrome: an overview. (9086580)
1997
26
Transiently decreased sialylation of thyrotropin (TSH) in a patient with the euthyroid sick syndrome. (9086572)
1997
27
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. (9349590)
1997
28
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? (9024211)
1997
29
Nonthyroidal illness syndrome or euthyroid sick syndrome? (15251561)
1996
30
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. (11862240)
1996
31
Euthyroid sick syndrome in psychiatric inpatients. (8959294)
1996
32
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome. (7834406)
1995
33
Cardiopulmonary bypass temperature does not affect postoperative euthyroid sick syndrome? (7497757)
1995
34
Distinguishing hypothyroxinemia due to euthyroid sick syndrome from pituitary insufficiency. (7960686)
1994
35
Possible etiology for euthyroid sick syndrome. (8455465)
1993
36
Heart transplantation, euthyroid sick syndrome, and triiodothyronine replacement. (1515440)
1992
37
Triiodothyronine replacement, the euthyroid sick syndrome, and organ transplantation. (1926432)
1991
38
Euthyroid sick syndrome in children with acute viral hepatitis A. (1867890)
1991
39
The euthyroid sick syndrome. (1853787)
1991
40
Euthyroid sick syndrome in type I diabetes mellitus in children and adolescents. (1867879)
1991
41
The euthyroid sick syndrome. (1776598)
1991
42
Euthyroid sick syndrome. (3919544)
1985
43
Malignant Mediterranean spotted fever. Report of a case with multiple organ failure, hypocalcemia, and euthyroid sick syndrome. (3839356)
1985
44
Familial hyperlipidaemia with multiple xanthomatosis and euthyroid sick syndrome. (6724629)
1984
45
Euthyroid sick syndrome. Association with urosepsis in an elderly man. (6371753)
1984
46
Euthyroid sick syndrome and free thyroxine assay. (6135016)
1983
47
Frequency of euthyroid sick syndrome as assessed by free thyroxine index and a direct free thyroxine assay. A limitation of FT4 assays. (6134145)
1983
48
Euthyroid sick syndrome and free thyroxine assay. (6135900)
1983
49
Euthyroid sick syndrome. (7295055)
1981
50
Euthyroid sick syndrome. (714120)
1978

Variations for Euthyroid Sick Syndrome

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Expression for genes affiliated with Euthyroid Sick Syndrome

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Expression patterns in normal tissues for genes affiliated with Euthyroid Sick Syndrome

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Pathways for genes affiliated with Euthyroid Sick Syndrome

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Pathways related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9DIO1, DIO2
2
Show member pathways
9.6POMC, TRH
39.6IL6, IL1B
49.6IL1B, IL6
59.6IL6, IL1B
69.6IL1B, IL6
79.6IL1B, IL6
89.6IL6, IL1B
99.6IL1B, IL6
10
Show member pathways
creatine-phosphate biosynthesis37
glycine degradation (creatine biosynthesis)37
putrescine biosynthesis III37
spermidine biosynthesis I37
tryptophan degradation via kynurenine37
spermine biosynthesis37
urea cycle37
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I37
tyrosine degradation I37
L-carnitine biosynthesis37
methylthiopropionate biosynthesis37
2-oxoglutarate decarboxylation to succinyl-CoA37
S-methyl-5-thioadenosine degradation II37
9.5DIO1, DIO2, GPT
11
Show member pathways
thioredoxin pathway37
8.5ALB, IL1B, IL6, DIO1, DIO2

Compounds for genes affiliated with Euthyroid Sick Syndrome

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Compounds related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1Thyroxine sulfate2410.2DIO2, DIO1
2iodide44 2411.0DIO1, DIO2, SERPINA7
3muramyl tripeptide phosphatidylethanolamine449.9IL6, IL1B
4turpentine449.8IL1B, IL6
5sevoflurane50 44 1111.6GPT, NPPB, ALB
6hepaplastin449.6ALB, GPT
7pyridoxal 5-phosphate449.6POMC, GPT, ALB
8liothyronine50 24 1111.5DIO2, DIO1, SERPINA7, ALB
9iodine44 2410.5DIO2, SERPINA7, DIO1, TRH
10rosuvastatin44 50 28 1112.5GPT, ALB, IL6
11methimazole44 2 1111.5TRH, DIO2, POMC, SERPINA7
12corticosterone44 61 2411.5GPT, SERPINA7, IL1B, POMC
13pentoxifylline44 1110.4IL6, IL1B, NPPB
14spironolactone44 61 28 50 1113.4ALB, SERPINA7, POMC, NPPB
15furosemide44 61 28 50 24 1114.4SERPINA7, NPPB, ALB, POMC
16naloxone44 28 50 1112.4TRH, POMC, ALB
17neopterin449.4IL1B, IL6, GPT
18aspirin44 50 28 2412.4SERPINA7, NPPB, POMC, IL1B
19ribonucleic acid449.4IL1B, DIO2, POMC, SERPINA7
20diazepam44 28 50 1112.4ALB, TRH, POMC
21haloperidol44 50 28 2 1113.3GPT, POMC, NPPB, TRH
22pravastatin44 50 28 24 1113.3NPPB, IL6, GPT, IL1B
23ibuprofen44 28 50 24 1113.3IL6, IL1B, ALB
24rosiglitazone28 44 50 24 1113.2ALB, NPPB, IL6, GPT
25urea44 24 1111.2SERPINA7, ALB, TRH, GPT
26ivig449.2ALB, IL1B, IL6, GPT
27hydrocortisone44 2 61 1112.2IL1B, POMC, TRH, IL6
28hyaluronic acid44 2410.1GPT, IL6, ALB, IL1B
29methotrexate50 44 1111.1IL6, GPT, ALB, IL1B
30pioglitazone28 44 50 1112.0IL6, GPT, NPPB
31dopamine44 28 24 1112.0TRH, SERPINA7, NPPB, POMC, DIO2
32vitamin d449.0ALB, IL6, GPT, NPPB
33prednisolone44 28 1110.9GPT, IL6, ALB, POMC, NPPB
34acth448.9POMC, SERPINA7, IL6, TRH, IL1B
35norepinephrine44 24 1110.9IL6, POMC, TRH, NPPB
36forskolin44 50 1110.9TRH, NPPB, IL1B, DIO2, POMC
37estradiol44 24 1110.9TRH, NPPB, ALB, POMC, SERPINA7
38indomethacin44 28 61 1111.8IL6, POMC, NPPB, IL1B, ALB
39cycloheximide448.8TRH, IL1B, IL6, DIO2, POMC
40alanine448.7ALB, GPT, POMC, SERPINA7, DIO2, IL6
41creatinine448.7ALB, POMC, IL6, SERPINA7, GPT, NPPB
42arginine448.6NPPB, TRH, SERPINA7, POMC, GPT
43estrogen448.6DIO2, NPPB, POMC, TRH, IL6, SERPINA7
44histamine44 28 2410.6IL6, IL1B, NPPB, ALB
45dexamethasone44 50 28 1111.5IL6, TRH, NPPB, IL1B, DIO2, POMC
46testosterone44 61 24 1111.5SERPINA7, IL6, ALB, NPPB, TRH, POMC
47triiodothyronine448.2DIO1, DIO2, POMC, SERPINA7, THRSP, TRH
48lipid447.8THRSP, TRH, NPPB, IL6, SERPINA7, GPT
49thyroxine44 248.4THRSP, POMC, DIO2, DIO1, NPPB, TRH
50glucose447.2DIO2, TRH, ALB, IL6, POMC, SERPINA7

GO Terms for genes affiliated with Euthyroid Sick Syndrome

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Cellular components related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.2TRH, IL1B, POMC
2extracellular spaceGO:0056157.8SERPINA7, POMC, IL6, IL1B, ALB, NPPB
3extracellular regionGO:0055767.5TRH, SERPINA7, POMC, IL6, IL1B, ALB

Biological processes related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:04244610.1DIO1, DIO2
2thyroid hormone generationGO:00659010.1DIO1, DIO2
3response to corticosteroneGO:0514129.8SERPINA7, TRH
4positive regulation of nitric oxide biosynthetic processGO:0454299.7IL6, IL1B
5cellular nitrogen compound metabolic processGO:0346419.7DIO1, DIO2, GPT
6positive regulation of T cell proliferationGO:0421029.6IL1B, IL6
7response to coldGO:0094099.5IL6, TRH
8positive regulation of interleukin-6 productionGO:0327559.3IL1B, IL6
9cell-cell signalingGO:0072679.1TRH, IL1B, POMC

Molecular functions related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1selenium bindingGO:0084309.9DIO1, DIO2
2thyroxine 5-deiodinase activityGO:0048009.8DIO1, DIO2
3pyridoxal phosphate bindingGO:0301708.5ALB, GPT, GOT1L1

Products for genes affiliated with Euthyroid Sick Syndrome

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Sources for Euthyroid Sick Syndrome

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3CDC
13ExPASy
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25ICD10
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