MCID: ETH004
MIFTS: 39

Euthyroid Sick Syndrome malady

Summaries for Euthyroid Sick Syndrome

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Wikipedia:63 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), non-thyroidal illness syndrome (NTIS) or... more...

MalaCards based summary: Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to thyroiditis and hypothyroidism. An important gene associated with Euthyroid Sick Syndrome is SERPINA7 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7), and among its related pathways are Selenium Metabolism and Selenoproteins and Development Leptin signaling via JAK STAT and MAPK cascades. The compounds Thyroxine sulfate and iodide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Classifications for Euthyroid Sick Syndrome

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Euthyroid Sick Syndrome, Aliases & Descriptions:

Name: Euthyroid Sick Syndrome 9 11
Euthyroid Sick Syndromes 43 60
 
Sick-Euthyroid Syndrome 9


External Ids:

Disease Ontology9 DOID:2856
MeSH33 D005067
SNOMED-CT55 237542005
ICD9CM27 790.94

Related Diseases for Euthyroid Sick Syndrome

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Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.2TRH, POMC, SERPINA7
2hypothyroidism31.0TRH, SERPINA7, THRSP
3cushing's syndrome30.8POMC, TRH
4acute adrenal insufficiency10.5POMC
5hypoaldosteronism10.5POMC
6acth deficiency10.5POMC
7choledocholithiasis10.5GPT
8protein-losing enteropathy10.4ALB
9thyrotoxicosis10.4TRH, SERPINA7
10thyroid hormone resistance10.4SERPINA7, TRH
11malaria10.4ALB
12empty sella syndrome10.3POMC, TRH
13thyroid adenoma10.3SERPINA7, DIO2
14melancholia10.3POMC, TRH
15pituitary apoplexy10.3TRH, POMC
16endogenous depression10.3TRH, POMC
17diabetes insipidus10.3TRH, POMC
18craniopharyngioma10.3POMC, TRH
19amenorrhea10.3POMC, TRH
20intervertebral disc disease10.3IL1B
21adrenal gland hyperfunction10.3POMC, TRH
22neuroendocrine tumor10.3POMC, TRH
23hyperprolactinemia10.3POMC, TRH
24periodontal disease10.3IL6
25hypopituitarism10.3TRH, POMC
26syndrome of inappropriate antidiuretic hormone10.3NPPB, POMC
27myocardial infarction10.2
28acute myocardial infarction10.2
29burns10.2
30congestive heart failure10.2
31hepatitis10.2
32diabetic ketoacidosis10.2
33hepatitis a10.2
34nephrotic syndrome10.2
35spotted fever10.2
36viral hepatitis10.2
37xanthomatosis10.2
38head injury10.2
39mediterranean spotted fever10.2
40goiter10.2TRH, DIO2, SERPINA7
41panic disorder10.2POMC, TRH
42hyperthyroidism10.2TRH, DIO2, SERPINA7
43acute liver failure10.2ALB, GPT
44alcoholic hepatitis10.2GPT, ALB
45hepatic encephalopathy10.2GPT, ALB
46bilirubin metabolic disorder10.2GPT, ALB
47portal hypertension10.2GPT, ALB
48cholangitis10.2GPT, ALB
49kawasaki disease10.2GPT, NPPB
50pituitary adenoma10.2SERPINA7, POMC, TRH

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to euthyroid sick syndrome

Symptoms for Euthyroid Sick Syndrome

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Drugs & Therapeutics for Euthyroid Sick Syndrome

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Drug clinical trials:

Search ClinicalTrials for Euthyroid Sick Syndrome

Search NIH Clinical Center for Euthyroid Sick Syndrome

Genetic Tests for Euthyroid Sick Syndrome

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Anatomical Context for Euthyroid Sick Syndrome

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MalaCards organs/tissues related to Euthyroid Sick Syndrome:

31
Thyroid, Heart, Pituitary

Animal Models for Euthyroid Sick Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8ALB, IL1B, IL6, POMC
2MP:00053678.3POMC, DIO2, DIO1, IL6, ALB
3MP:00053797.5TRH, THRSP, POMC, DIO2, DIO1, IL6
4MP:00053766.9THRSP, POMC, DIO2, DIO1, IL6, IL1B

Publications for Euthyroid Sick Syndrome

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Articles related to Euthyroid Sick Syndrome:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Euthyroid sick syndrome in children with diabetic ketoacidosis. (25719594)
2015
2
Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis. (25154407)
2014
3
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. (23401683)
2013
4
Therapeutic effect of low-dose thyroxin in elderly patients with refractory heart failure and euthyroid sick syndrome]. (19778808)
2009
5
Is euthyroid sick syndrome a defensive mechanism against oxidative stress? (18524495)
2008
6
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. (19007679)
2008
7
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. (17356583)
2007
8
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. (16734083)
2006
9
Euthyroid sick syndrome in trauma patients with severe inflammatory response syndrome. (16533439)
2006
10
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. (16076941)
2005
11
Expression of euthyroid sick syndrome in postischaemic heart disease is related to increased cardiovascular mortality: new options for intervention?: Heart and hormones. (25696169)
2003
12
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? (15055468)
2003
13
Euthyroid sick syndrome in acute ischemic syndromes. (12463624)
2002
14
Euthyroid sick syndrome. (12005007)
2002
15
Euthyroid sick syndrome in children with Hodgkin disease. (11293290)
2001
16
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. (10913935)
2000
17
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. (14564609)
2000
18
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. (10930442)
2000
19
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. (11138334)
2000
20
Euthyroid sick syndrome. (17016284)
2000
21
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. (14600974)
2000
22
Changes in metabolism of TRH in euthyroid sick syndrome. (10526245)
1999
23
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. (10660848)
1999
24
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. (10094108)
1999
25
Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. (9591009)
1998
26
Euthyroid sick syndrome: recent physiopathologic findings]. (9793151)
1998
27
Role of cytokines in the pathogenesis of the euthyroid sick syndrome. (9678522)
1998
28
Euthyroid sick syndrome: an overview. (9086580)
1997
29
Transiently decreased sialylation of thyrotropin (TSH) in a patient with the euthyroid sick syndrome. (9086572)
1997
30
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. (9349590)
1997
31
Nonthyroidal illness syndrome or euthyroid sick syndrome? (15251561)
1996
32
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. (11862240)
1996
33
Euthyroid sick syndrome in psychiatric inpatients. (8959294)
1996
34
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome. (7834406)
1995
35
Cardiopulmonary bypass temperature does not affect postoperative euthyroid sick syndrome? (7497757)
1995
36
Distinguishing hypothyroxinemia due to euthyroid sick syndrome from pituitary insufficiency. (7960686)
1994
37
Possible etiology for euthyroid sick syndrome. (8455465)
1993
38
Plasma selenium concentrations in patients with euthyroid sick syndrome. (1526030)
1992
39
Heart transplantation, euthyroid sick syndrome, and triiodothyronine replacement. (1515440)
1992
40
Triiodothyronine replacement, the euthyroid sick syndrome, and organ transplantation. (1926432)
1991
41
Euthyroid sick syndrome in children with acute viral hepatitis A. (1867890)
1991
42
The euthyroid sick syndrome. (1853787)
1991
43
Euthyroid sick syndrome. (3919544)
1985
44
Malignant Mediterranean spotted fever. Report of a case with multiple organ failure, hypocalcemia, and euthyroid sick syndrome. (3839356)
1985
45
Familial hyperlipidaemia with multiple xanthomatosis and euthyroid sick syndrome. (6724629)
1984
46
Euthyroid sick syndrome. Association with urosepsis in an elderly man. (6371753)
1984
47
Euthyroid sick syndrome and free thyroxine assay. (6135016)
1983
48
Frequency of euthyroid sick syndrome as assessed by free thyroxine index and a direct free thyroxine assay. A limitation of FT4 assays. (6134145)
1983
49
Euthyroid sick syndrome and free thyroxine assay. (6135900)
1983
50
Euthyroid sick syndrome. (7295055)
1981

Variations for Euthyroid Sick Syndrome

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Expression for genes affiliated with Euthyroid Sick Syndrome

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Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for genes affiliated with Euthyroid Sick Syndrome

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Pathways related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9DIO1, DIO2
2
Show member pathways
9.6POMC, TRH
39.6IL6, IL1B
49.6IL1B, IL6
59.6IL6, IL1B
69.6IL1B, IL6
79.6IL1B, IL6
89.6IL6, IL1B
99.6IL1B, IL6
10
Show member pathways
creatine-phosphate biosynthesis36
glycine degradation (creatine biosynthesis)36
putrescine biosynthesis III36
spermidine biosynthesis I36
tryptophan degradation via kynurenine36
spermine biosynthesis36
urea cycle36
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I36
tyrosine degradation I36
L-carnitine biosynthesis36
methylthiopropionate biosynthesis36
2-oxoglutarate decarboxylation to succinyl-CoA36
S-methyl-5-thioadenosine degradation II36
9.5DIO1, DIO2, GPT
11
Show member pathways
thioredoxin pathway36
8.5ALB, IL1B, IL6, DIO1, DIO2

Compounds for genes affiliated with Euthyroid Sick Syndrome

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Compounds related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1Thyroxine sulfate2410.2DIO2, DIO1
2iodide43 2411.0DIO1, DIO2, SERPINA7
3muramyl tripeptide phosphatidylethanolamine439.9IL6, IL1B
4turpentine439.8IL1B, IL6
5sevoflurane49 43 1211.6GPT, NPPB, ALB
6hepaplastin439.6ALB, GPT
7pyridoxal 5-phosphate439.6POMC, GPT, ALB
8liothyronine49 24 1211.5DIO2, DIO1, SERPINA7, ALB
9iodine43 2410.5DIO2, SERPINA7, DIO1, TRH
10rosuvastatin43 49 28 1212.5GPT, ALB, IL6
11methimazole43 2 1211.5TRH, DIO2, POMC, SERPINA7
12corticosterone43 59 2411.5GPT, SERPINA7, IL1B, POMC
13pentoxifylline43 1210.4IL6, IL1B, NPPB
14spironolactone43 59 28 49 1213.4ALB, SERPINA7, POMC, NPPB
15furosemide43 59 28 49 24 1214.4SERPINA7, NPPB, ALB, POMC
16naloxone43 28 49 1212.4TRH, POMC, ALB
17neopterin439.4IL1B, IL6, GPT
18aspirin43 49 28 2412.4SERPINA7, NPPB, POMC, IL1B
19ribonucleic acid439.4IL1B, DIO2, POMC, SERPINA7
20diazepam43 28 49 1212.4ALB, TRH, POMC
21haloperidol43 49 28 2 1213.3GPT, POMC, NPPB, TRH
22pravastatin43 49 28 24 1213.3NPPB, IL6, GPT, IL1B
23ibuprofen43 28 49 24 1213.3IL6, IL1B, ALB
24rosiglitazone28 43 49 24 1213.2ALB, NPPB, IL6, GPT
25urea43 24 1211.2SERPINA7, ALB, TRH, GPT
26ivig439.2ALB, IL1B, IL6, GPT
27hydrocortisone43 2 59 1212.2IL1B, POMC, TRH, IL6
28hyaluronic acid43 2410.1GPT, IL6, ALB, IL1B
29methotrexate49 43 1211.1IL6, GPT, ALB, IL1B
30pioglitazone28 43 49 1212.0IL6, GPT, NPPB
31dopamine43 28 24 1212.0TRH, SERPINA7, NPPB, POMC, DIO2
32vitamin d439.0ALB, IL6, GPT, NPPB
33prednisolone43 28 1210.9GPT, IL6, ALB, POMC, NPPB
34acth438.9POMC, SERPINA7, IL6, TRH, IL1B
35norepinephrine43 24 1210.9IL6, POMC, TRH, NPPB
36forskolin43 49 1210.9TRH, NPPB, IL1B, DIO2, POMC
37estradiol43 24 1210.9TRH, NPPB, ALB, POMC, SERPINA7
38indomethacin43 28 59 1211.8IL6, POMC, NPPB, IL1B, ALB
39cycloheximide438.8TRH, IL1B, IL6, DIO2, POMC
40alanine438.7ALB, GPT, POMC, SERPINA7, DIO2, IL6
41creatinine438.7ALB, POMC, IL6, SERPINA7, GPT, NPPB
42arginine438.6NPPB, TRH, SERPINA7, POMC, GPT
43estrogen438.6DIO2, NPPB, POMC, TRH, IL6, SERPINA7
44histamine43 28 2410.6IL6, IL1B, NPPB, ALB
45dexamethasone43 49 28 1211.5IL6, TRH, NPPB, IL1B, DIO2, POMC
46testosterone43 59 24 1211.5SERPINA7, IL6, ALB, NPPB, TRH, POMC
47triiodothyronine438.2DIO1, DIO2, POMC, SERPINA7, THRSP, TRH
48lipid437.8THRSP, TRH, NPPB, IL6, SERPINA7, GPT
49thyroxine43 248.4THRSP, POMC, DIO2, DIO1, NPPB, TRH
50glucose437.2DIO2, TRH, ALB, IL6, POMC, SERPINA7

GO Terms for genes affiliated with Euthyroid Sick Syndrome

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Cellular components related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:00301419.2TRH, IL1B, POMC
2extracellular spaceGO:00056157.8SERPINA7, POMC, IL6, IL1B, ALB, NPPB
3extracellular regionGO:00055767.5TRH, SERPINA7, POMC, IL6, IL1B, ALB

Biological processes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.1DIO1, DIO2
2thyroid hormone generationGO:000659010.1DIO1, DIO2
3response to corticosteroneGO:00514129.8SERPINA7, TRH
4positive regulation of nitric oxide biosynthetic processGO:00454299.7IL6, IL1B
5cellular nitrogen compound metabolic processGO:00346419.7DIO1, DIO2, GPT
6positive regulation of T cell proliferationGO:00421029.6IL1B, IL6
7response to coldGO:00094099.5IL6, TRH
8positive regulation of interleukin-6 productionGO:00327559.3IL1B, IL6
9cell-cell signalingGO:00072679.1TRH, IL1B, POMC

Molecular functions related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1selenium bindingGO:00084309.9DIO1, DIO2
2thyroxine 5-deiodinase activityGO:00048009.8DIO1, DIO2
3pyridoxal phosphate bindingGO:00301708.5ALB, GPT, GOT1L1

Products for genes affiliated with Euthyroid Sick Syndrome

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Sources for Euthyroid Sick Syndrome

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