MCID: ETH004
MIFTS: 38

Euthyroid Sick Syndrome malady

Category: Endocrine diseases

Aliases & Classifications for Euthyroid Sick Syndrome

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Aliases & Descriptions for Euthyroid Sick Syndrome:

Name: Euthyroid Sick Syndrome 11 13
Euthyroid Sick Syndromes 50 39 68
 
Sick-Euthyroid Syndrome 11

Classifications:



External Ids:

Disease Ontology11 DOID:2856
ICD1030 E07.81
ICD9CM32 790.94
SNOMED-CT62 237542005
MeSH39 D005067
NCIt45 C113170

Summaries for Euthyroid Sick Syndrome

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Wikipedia:71 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), thyroid allostasis in critical illness,... more...

MalaCards based summary: Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to hypothyroidism and xanthomatosis, and has symptoms including pain in thyroid and lid lag. An important gene associated with Euthyroid Sick Syndrome is IL6 (Interleukin 6), and among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Malaria. Affiliated tissues include thyroid, heart and placenta, and related mouse phenotype neoplasm.

Related Diseases for Euthyroid Sick Syndrome

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Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism30.4IL1B, IL6
2xanthomatosis29.6IL1B, IL6
3myocardial infarction28.6ALB, IL1B, IL6, NPPB
4dystonia 410.5ALB, SERPINA7
5hemoglobin c disease10.5ALB, SERPINA7
6atrophic vulva10.4ALB, IL6
7autosomal dominant cerebellar ataxia10.4ALB, IL6
8antidepressant type abuse10.4ALB, IL6
9sweat gland cancer10.4ALB, IL6
10urinary bladder posterior wall cancer10.4ALB, IL6
1110.4ALB, IL6
12cartilage disease10.4ALB, IL1B
13ischemic heart disease10.4ALB, IL6
14chronic apical periodontitis10.4ALB, IL6
15lupus erythematosus10.4ALB, IL1B
16conjunctival disease10.4ALB, IL6
17iridocyclitis10.3ALB, IL6
18alopecia10.3ALB, IL6
19gender identity disorder10.3ALB, IL6
20neurogenic bowel10.3ALB, IL6
21corneal deposit10.3IL1B, IL6
22tarsal tunnel syndrome10.3IL1B, IL6
23scrotum paget's disease10.3IL1B, IL6
24midline interhemispheric variant of holoprosencephaly10.3IL1B, IL6
25melorheostosis10.3IL1B, IL6
26infancy electroclinical syndrome10.3IL1B, IL6
27autoimmune polyendocrine syndrome10.3IL1B, IL6
28gastric ulcer10.3ALB, IL6
29skin disease10.3IL1B, IL6
30conventional leiomyosarcoma10.3IL1B, IL6
31scarlet fever10.3IL1B, IL6
32subglottis neoplasm10.3IL1B, IL6
33extrahepatic cholestasis10.3ALB, IL6
34non-secretory myeloma10.3IL1B, IL6
35qualitative platelet defect10.3IL1B, IL6
36inflammatory spondylopathy10.3IL1B, IL6
37sterility due to immotile flagella10.3IL1B, IL6
38syphilitic encephalitis10.3IL1B, IL6
39ocular cancer10.3IL1B, IL6
40orbital lymphangioma10.3IL1B, IL6
41periodic paralyses10.3IL1B, IL6
42thyroiditis10.3
43paraneoplastic polyneuropathy10.3IL1B, IL6
44scn8a encephalopathy10.3IL1B, IL6
45human monocytic ehrlichiosis10.3IL1B, IL6
46philophthalmiasis10.3IL1B, IL6
47thoracic aortic aneurysm10.3IL1B, IL6
48ulcerative colitis10.3IL1B, IL6
49ampulla of vater neoplasm10.3IL1B, IL6
50oral candidiasis10.3IL1B, IL6

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to euthyroid sick syndrome

Symptoms & Phenotypes for Euthyroid Sick Syndrome

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UMLS symptoms related to Euthyroid Sick Syndrome:


pain in thyroid, lid lag

MGI Mouse Phenotypes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5ALB, IL1B, IL6, POMC

Drugs & Therapeutics for Euthyroid Sick Syndrome

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Drugs for Euthyroid Sick Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcysteineapprovedPhase 4316616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
2
Magnesium oxideapprovedPhase 4631309-48-414792
Synonyms:
 
Magmitt
3HormonesPhase 4, Phase 213979
4ExpectorantsPhase 4388
5N-monoacetylcystinePhase 4316
6Respiratory System AgentsPhase 44818
7AntacidsPhase 41767
8Antiviral AgentsPhase 49732
9Protective AgentsPhase 47190
10Anti-Ulcer AgentsPhase 41767
11AntioxidantsPhase 42928
12Gastrointestinal AgentsPhase 48109
13Calcium, DietaryPhase 45525
14Anti-Infective AgentsPhase 421402
15AntidotesPhase 41038
16Central Nervous System DepressantsPhase 312806
17AnestheticsPhase 3, Phase 29001
18
Hydroxocobalaminapproved24813422-51-011953898, 5460373, 44475014
Synonyms:
13422-51-0
22465-48-1
78091-12-0
8017-22-9
Acti-B12
AlphaRedisol
AlphaRedisol (TN)
Axion
Axlon
Benzimidazolyl ribofuranosyl phosphate deriv.
C08230
C62H85CoN13O15P
CHEBI:27786
CHEMBL1200742
CHEMBL235822
CID11622291
CID11953898
CID5460373
CID6433575
CID6474319
Ciplamin H
Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-hydroxocobamide
Cobalex
Cobalin H
Cobinamide dihydroxide dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-a-D-ribofuranosylbenzimidazole inner salt
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole inner salt
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosylbenzimidazole inner salt
Cobinamide, Co-hydroxy-, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3)
Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3)
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono (inner salt), 3'- ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Cobinamide, hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Codroxomin
Cyanokit
Cyanokit (TN)
D01027
DB00200
Depogamma
Docclan
Docelan
Docelvita
Docevita
Droxomin
Ducobee Hy
Ducobee-Hy
Duradoce
Duralta-12
EINECS 236-533-2
HSDB 3342
HYDROXOCOBALAMIN
Hidroxocobalamina
Hidroxocobalamina [INN-Spanish]
Hydro Cobex
 
Hydrobamine
Hydrocobalamin
Hydrogrisevit
Hydrovit
Hydroxocobalamin
Hydroxocobalamin (JAN/USP/INN)
Hydroxocobalamin Vitamin B12
Hydroxocobalamin [USAN:INN:BAN:JAN]
Hydroxocobalamin acetate
Hydroxocobalamin anhydrous
Hydroxocobalamin monohydrochloride
Hydroxocobalamin(alkaline soln.), OH- replaces CN- in Cyanocobalamin)
Hydroxocobalaminacetat
Hydroxocobalamine
Hydroxocobalamine [INN-French]
Hydroxocobalaminum
Hydroxocobalaminum [INN-Latin]
Hydroxocobalaminum anhydrous
Hydroxocobemine
Hydroxomin
Hydroxy Cobal
Hydroxy vitamin B12
Hydroxycob(lll)alamin
Hydroxycobalamin
Hydroxycobalamine
Hyxobamine
Idrogrisevit
Idrossocobalamina
Idrossocobalamina [DCIT]
LS-54607
Lyovit-H
Neo-Betalin 12
Neo-cytamen
Neo-macrabin
Neo-rojamin
OH-Cbl
OH-Duphar
Ohb12
Oxobemin
Oxolamine (arcum)
Primabalt RP
Redisol-H
S1668_Selleck
Sytobex-H
UNII-Q40X8H422O
Vibeden
Vitadurin
Vitamin B(sub 12a)
Vitamin B-12b
Vitamin B12a
Vitamin B12b
a-(5,6-Dimethylbenzimidazolyl)hydroxocobamide
alpha Cobione
alpha-(5,6-Dimethylbenzimidazolyl)hydroxocobamide
vitamin B-12b
19
Cyanocobalaminapproved, nutraceutical24968-19-944176380
Synonyms:
Anacobin
Bedoz
Berocca PN
Berubigen
Betalin 12
Betalin 12 Crystalline
Betaline-12
Betolvex
Bevidox
Bevidox concentrate
Biocobalamine
Byladoce
Cabadon m
Cernevit-12
Cobadoce forte
Cobalin
Cobavite
Cobex
Cobolin-M
Copharvit 5000
Covit
Crystamin
Crystamine
Crysti-12
Crystimin
Crystwel
Cyano-B12
Cyanobalamin concentrate
Cyanocob(III)alamin
Cyanocobalamin (JP15/USP)
Cyanocobalamin Co 57 Schilling Test Kit
Cyanocobalamine
Cyanocobalmin
Cyanoject
Cycobemin
Cycolamin
Cykobemin
Cykobeminet
Cyomin
Cyredin
Cytacon
Cytamen
Cytobion
Depinar
Dicopac
Dicopac Kit
Dimethylbenzimidazoylcobamide
Distivit
Docemine
Docibin
Docivit
Dodecabee
Dodecavite
Dodex
Duodecibin
Embiol
Emociclina
Eritrone
Erycytol
 
Erythrotin
Euhaemon
Extrinsic factor
Factor II
Fermin
Fresmin
Hemomin
Hepagon
Hepavis
Hepcovite
Hylugel plus
Infuvite Pediatric
Lactobacillus lactis dorner factor
M.V.I. Pediatric
Macrabin
Megabion
Megalovel
Milbedoce
Millevit
Nagravon
Nascobal
Nascobal (TN)
Neuroforte-R
Normocytin
Novidroxin
Pernaemon
Pernaevit
Pernipuron
Plecyamin
Poyamin
Primabalt
Rebramin
Redamina
Redisol
Rhodacryst
Rubesol
Rubivite
Rubramin
Rubramin PC
Rubratope-57 Kit
Rubratope-60 Kit
Rubripca
Rubrocitol
Ruvite
Shovite
Sytobex
Vi-Twel
Vibal
Vibalt
Vibisone
Virubra
Vita-rubra
Vitabee 12
Vitamin B12
Vitamin B12 Preparation
Vitamin B12 complex
Vitaped
Vitarubin
Vitral
vitamine b12
20Hormone Antagonists12778
21Hormones, Hormone Substitutes, and Hormone Antagonists12767
22Vitamins5095
23Vitamin B Complex4229
24Vitamin B 12249
25
Methylcobalaminexperimental, Nutraceutical24813422-55-4
Synonyms:
Algobaz
Co-Methylcobalamin
Co-methylcobalamin
Hitocobamin M
MeCbl
Mecobalamin
Methycobal
 
Methyl cobalamine
Methyl vitamin B12
Methyl-5,6-dimethylbenzimidazolylcobalamin
Methyl-B12
Methylcob(III)alamin
Methylcobalamin
Methylcobaz
mecobalamin
methyl(III)cobalamin
26Vitamin B12Nutraceutical249
27
CobalaminNutraceutical24913408-78-16438156
Synonyms:
5,6-Dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole
5,6-Dimethyl-1-a-D-ribofuranosylbenzimidazole
5,6-Dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole
5,6-Dimethyl-1-alpha-delta-ribofuranosylbenzimidazole
Cob(III)alamin
Cobalamin (III)
Cobalamine
 
Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester
Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole
Hydroxomin
Rubivite
Rubratope-57
Rubratope-60
Ruvite
Vitamin B12

Interventional clinical trials:

(show all 11)
idNameStatusNCT IDPhase
1Levothyroxine for Children With Euthyroid Sick SyndromeCompletedNCT01631305Phase 4
2Effects of N-acetylcysteine on Low T3 SyndromeCompletedNCT01501110Phase 4
3Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in IndonesiaCompletedNCT02521168Phase 3
4Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in IndonesiaCompletedNCT02222532Phase 3
5Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children?CompletedNCT01780584Phase 2
6The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental ImplicationsUnknown statusNCT01466023
7Investigating the Role of EN in NTIS Among Fistula PatientsCompletedNCT02038504
8Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass SurgeryCompletedNCT01153360
9An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation EnteritisCompletedNCT02452073
10Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF)CompletedNCT01481402
11Approach to a Quantitative Follow-up of Non-thyroidal Illness SyndromeActive, not recruitingNCT00591032

Search NIH Clinical Center for Euthyroid Sick Syndrome


Cochrane evidence based reviews: euthyroid sick syndromes

Genetic Tests for Euthyroid Sick Syndrome

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Anatomical Context for Euthyroid Sick Syndrome

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MalaCards organs/tissues related to Euthyroid Sick Syndrome:

36
Thyroid, Heart, Placenta, Pituitary

Publications for Euthyroid Sick Syndrome

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Articles related to Euthyroid Sick Syndrome:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome. (27737323)
2016
2
Euthyroid Sick Syndrome. (27065175)
2016
3
Euthyroid sick syndrome in children with diabetic ketoacidosis. (25719594)
2015
4
Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis. (25154407)
2014
5
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. (23401683)
2013
6
Euthyroid sick syndrome and nutritional status are correlated with hyposelenemia in hemodialysis patients. (21786251)
2011
7
Therapeutic effect of low-dose thyroxin in elderly patients with refractory heart failure and euthyroid sick syndrome]. (19778808)
2009
8
Is euthyroid sick syndrome a defensive mechanism against oxidative stress? (18524495)
2008
9
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. (19007679)
2008
10
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. (17356583)
2007
11
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. (16734083)
2006
12
Euthyroid sick syndrome in trauma patients with severe inflammatory response syndrome. (16533439)
2006
13
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. (16076941)
2005
14
Expression of euthyroid sick syndrome in postischaemic heart disease is related to increased cardiovascular mortality: new options for intervention?: Heart and hormones. (25696169)
2003
15
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? (15055468)
2003
16
Euthyroid sick syndrome. (12005007)
2002
17
Interferon-gamma administration does not affect human thyroid hormone metabolism in the post-surgical euthyroid sick syndrome. (12030601)
2002
18
Euthyroid sick syndrome in acute ischemic syndromes. (12463624)
2002
19
Euthyroid sick syndrome in children with Hodgkin disease. (11293290)
2001
20
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. (10913935)
2000
21
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. (14564609)
2000
22
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. (10930442)
2000
23
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. (11138334)
2000
24
Euthyroid sick syndrome. (17016284)
2000
25
Euthyroid Sick Syndrome and the role of cytokines. (11704991)
2000
26
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. (14600974)
2000
27
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. (10094108)
1999
28
Changes in metabolism of TRH in euthyroid sick syndrome. (10526245)
1999
29
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. (10660848)
1999
30
Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. (9591009)
1998
31
Euthyroid sick syndrome: recent physiopathologic findings]. (9793151)
1998
32
Role of cytokines in the pathogenesis of the euthyroid sick syndrome. (9678522)
1998
33
Transiently decreased sialylation of thyrotropin (TSH) in a patient with the euthyroid sick syndrome. (9086572)
1997
34
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. (9349590)
1997
35
Euthyroid sick syndrome: an overview. (9086580)
1997
36
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? (9024211)
1997
37
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. (11862240)
1996
38
Euthyroid sick syndrome in psychiatric inpatients. (8959294)
1996
39
Nonthyroidal illness syndrome or euthyroid sick syndrome? (15251561)
1996
40
Cardiopulmonary bypass temperature does not affect postoperative euthyroid sick syndrome? (7497757)
1995
41
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome. (7834406)
1995
42
Reverse T3 does not reliably differentiate hypothyroid sick syndrome from euthyroid sick syndrome. (8808092)
1995
43
Distinguishing hypothyroxinemia due to euthyroid sick syndrome from pituitary insufficiency. (7960686)
1994
44
Possible etiology for euthyroid sick syndrome. (8455465)
1993
45
Plasma selenium concentrations in patients with euthyroid sick syndrome. (1526030)
1992
46
Heart transplantation, euthyroid sick syndrome, and triiodothyronine replacement. (1515440)
1992
47
Euthyroid sick syndrome in type I diabetes mellitus in children and adolescents. (1867879)
1991
48
Triiodothyronine replacement, the euthyroid sick syndrome, and organ transplantation. (1926432)
1991
49
Euthyroid sick syndrome in children with acute viral hepatitis A. (1867890)
1991
50
The euthyroid sick syndrome. (1853787)
1991

Variations for Euthyroid Sick Syndrome

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Expression for genes affiliated with Euthyroid Sick Syndrome

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Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for genes affiliated with Euthyroid Sick Syndrome

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GO Terms for genes affiliated with Euthyroid Sick Syndrome

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Cellular components related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.3ALB, IL1B, IL6, NPPB, POMC, SERPINA7
2extracellular spaceGO:00056157.6ALB, IL1B, IL6, NPPB, POMC, SERPINA7

Biological processes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-6 productionGO:003275510.2IL1B, IL6
2positive regulation of nitric oxide biosynthetic processGO:004542910.1IL1B, IL6
3response to heatGO:00094089.7IL1B, IL6

Molecular functions related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.0IL6, NPPB, POMC

Sources for Euthyroid Sick Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet