MCID: ETH004
MIFTS: 36

Euthyroid Sick Syndrome

Categories: Endocrine diseases

Aliases & Classifications for Euthyroid Sick Syndrome

MalaCards integrated aliases for Euthyroid Sick Syndrome:

Name: Euthyroid Sick Syndrome 12 14
Euthyroid Sick Syndromes 52 42 69
Sick-Euthyroid Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2856
ICD10 33 E07.81
ICD9CM 35 790.94
MeSH 42 D005067
NCIt 47 C113170
SNOMED-CT 64 237542005
UMLS 69 C0015190

Summaries for Euthyroid Sick Syndrome

MalaCards based summary : Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to myocardial infarction and early-onset severe reducing body myopathy, x-linked. An important gene associated with Euthyroid Sick Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are Lung fibrosis and Photodynamic therapy-induced NF-kB survival signaling. The drugs Magnesium oxide and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and placenta, and related phenotype is neoplasm.

Wikipedia : 72 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), thyroid allostasis in critical illness,... more...

Related Diseases for Euthyroid Sick Syndrome

Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
id Related Disease Score Top Affiliating Genes
1 myocardial infarction 28.4 ALB IL1B IL6 NPPB
2 early-onset severe reducing body myopathy, x-linked 10.6 ALB SERPINA7
3 hemoglobinopathy 10.6 ALB SERPINA7
4 lung occult large cell carcinoma 10.5 IL6 SERPINA7
5 labyrinthine bilateral reactive loss 10.5 ALB IL6
6 vulvar sarcoma 10.5 ALB IL6
7 amelogenesis imperfecta, hypomaturation type, iia6 10.5 DIO2 SERPINA7
8 hepadnavirus infection 10.5 ALB IL6
9 cerebral lipidosis 10.5 DIO2 SERPINA7
10 allergic bronchopulmonary aspergillosis 10.5 ALB IL6
11 hyperlipoproteinemia type iv 10.5 ALB IL6
12 breast papillary carcinoma 10.5 ALB IL6
13 cataract 10.5 ALB IL1B
14 plummer's disease 10.4 ALB IL6
15 bladder sarcoma 10.4 ALB IL6
16 late yaws 10.4 ALB IL6
17 tonsil cancer 10.4 ALB IL1B
18 brain meningioma 10.4 ALB IL6
19 oculomotor nerve paralysis 10.4 IL1B IL6
20 common peroneal nerve lesion 10.4 IL1B IL6
21 ischemic heart disease 10.4 ALB IL6
22 arthus reaction 10.4 ALB IL1B
23 scrotal carcinoma 10.4 IL1B IL6
24 x-linked dominant intellectual disability-epilepsy syndrome 10.4 IL1B IL6
25 infancy electroclinical syndrome 10.4 IL1B IL6
26 upper gum cancer 10.4 IL1B IL6
27 bipolar i disorder 10.4 IL1B IL6
28 tinea favosa 10.4 IL1B IL6
29 central nervous system leiomyosarcoma 10.4 IL1B IL6
30 indolent myeloma 10.4 IL1B IL6
31 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 10.4 IL1B IL6
32 melorheostosis 10.4 ALB IL6
33 scoliosis, arachnodactyly, and blindness 10.4 IL1B IL6
34 subglottis neoplasm 10.4 IL1B IL6
35 bullous retinoschisis 10.4 IL1B IL6
36 carbuncle 10.4 IL1B IL6
37 dentinogenesis imperfecta 10.4 ALB IL6
38 philophthalmiasis 10.4 IL1B IL6
39 syphilitic encephalitis 10.4 IL1B IL6
40 early-onset zonular cataract 10.4 IL1B IL6
41 acquired thrombocytopenia 10.4 IL1B IL6
42 ampulla of vater neoplasm 10.4 IL1B IL6
43 cutis laxa, autosomal recessive, type ia 10.4 POMC SERPINA7
44 benign neonatal seizures 10.4 IL1B IL6
45 chronic endophthalmitis 10.4 ALB IL6
46 keloids 10.4 IL1B IL6
47 cholera 10.4 IL1B IL6
48 brucella canis brucellosis 10.3 IL1B IL6
49 foodborne botulism 10.3 IL1B IL6
50 ovarian mucinous adenofibroma 10.3 IL1B IL6

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to Euthyroid Sick Syndrome

Symptoms & Phenotypes for Euthyroid Sick Syndrome

MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 ALB IL1B IL6 POMC

Drugs & Therapeutics for Euthyroid Sick Syndrome

Drugs for Euthyroid Sick Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium oxide Approved Phase 4 1309-48-4 14792
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
3 Antacids Phase 4
4 Anti-Ulcer Agents Phase 4
5 Calcium, Dietary Phase 4
6 Gastrointestinal Agents Phase 4
7 Antidotes Phase 4
8 Anti-Infective Agents Phase 4
9 Antioxidants Phase 4
10 Antiviral Agents Phase 4
11 Expectorants Phase 4
12 Hormones Phase 4,Phase 2
13 N-monoacetylcystine Phase 4
14 Protective Agents Phase 4
15 Respiratory System Agents Phase 4
16 Anesthetics Phase 3,Phase 2
17 Central Nervous System Depressants Phase 3
18
Hydroxocobalamin Approved 13422-51-0 11953898 5460373 44475014
19
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
20 Vitamin B 12
21 Vitamin B Complex
22 Vitamins
23 Hormone Antagonists
24 Hormones, Hormone Substitutes, and Hormone Antagonists
25
Cobalamin Nutraceutical 13408-78-1 6438156
26
Methylcobalamin Experimental, Nutraceutical 13422-55-4
27 Vitamin B12 Nutraceutical

Interventional clinical trials:

(show all 13)

id Name Status NCT ID Phase Drugs
1 Levothyroxine for Children With Euthyroid Sick Syndrome Completed NCT01631305 Phase 4 Levothyroxine
2 Effects of N-acetylcysteine on Low T3 Syndrome Completed NCT01501110 Phase 4 N-acetylcysteine
3 Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02521168 Phase 3 Oral triiodothyronine;Placebo
4 Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02222532 Phase 3 Tetronine;Placebo
5 Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? Completed NCT01780584 Phase 2 Oral T3 Low dose;Placebo;Oral T3 high dose
6 Investigating the Role of EN in NTIS Among Fistula Patients Completed NCT02038504
7 Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery Completed NCT01153360 liothyronine sodium;placebo
8 An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation Enteritis Completed NCT02452073
9 The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental Implications Completed NCT01466023
10 Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF) Completed NCT01481402 Liothyronine;Liothyronine
11 Respiratory Muscle Function After Thyroid Hormone Replacement Therapy in Nonthyroidal Illness Syndrome Recruiting NCT03157466
12 Feeding the Critically Ill During Phases of Altered Redox Status Recruiting NCT03085615
13 Approach to a Quantitative Follow-up of Non-thyroidal Illness Syndrome Active, not recruiting NCT00591032

Search NIH Clinical Center for Euthyroid Sick Syndrome

Cochrane evidence based reviews: euthyroid sick syndromes

Genetic Tests for Euthyroid Sick Syndrome

Anatomical Context for Euthyroid Sick Syndrome

MalaCards organs/tissues related to Euthyroid Sick Syndrome:

39
Thyroid, Heart, Placenta, Pituitary

Publications for Euthyroid Sick Syndrome

Articles related to Euthyroid Sick Syndrome:

(show top 50) (show all 61)
id Title Authors Year
1
Euthyroid Sick Syndrome. ( 27065175 )
2016
2
Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome. ( 27737323 )
2016
3
Euthyroid sick syndrome in children with diabetic ketoacidosis. ( 25719594 )
2015
4
Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis. ( 25154407 )
2014
5
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. ( 23401683 )
2013
6
Euthyroid sick syndrome and nutritional status are correlated with hyposelenemia in hemodialysis patients. ( 21786251 )
2011
7
[Therapeutic effect of low-dose thyroxin in elderly patients with refractory heart failure and euthyroid sick syndrome]. ( 19778808 )
2009
8
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. ( 19007679 )
2008
9
Is euthyroid sick syndrome a defensive mechanism against oxidative stress? ( 18524495 )
2008
10
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. ( 17356583 )
2007
11
Euthyroid sick syndrome in trauma patients with severe inflammatory response syndrome. ( 16533439 )
2006
12
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. ( 16734083 )
2006
13
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. ( 16076941 )
2005
14
Expression of euthyroid sick syndrome in postischaemic heart disease is related to increased cardiovascular mortality: new options for intervention?: Heart and hormones. ( 25696169 )
2003
15
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? ( 15055468 )
2003
16
Euthyroid sick syndrome in acute ischemic syndromes. ( 12463624 )
2002
17
Interferon-gamma administration does not affect human thyroid hormone metabolism in the post-surgical euthyroid sick syndrome. ( 12030601 )
2002
18
Euthyroid sick syndrome. ( 12005007 )
2002
19
Euthyroid sick syndrome in children with Hodgkin disease. ( 11293290 )
2001
20
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. ( 14564609 )
2000
21
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. ( 11138334 )
2000
22
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. ( 10930442 )
2000
23
Euthyroid sick syndrome. ( 17016284 )
2000
24
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. ( 10913935 )
2000
25
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. ( 14600974 )
2000
26
Euthyroid Sick Syndrome and the role of cytokines. ( 11704991 )
2000
27
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. ( 10660848 )
1999
28
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. ( 10094108 )
1999
29
Changes in metabolism of TRH in euthyroid sick syndrome. ( 10526245 )
1999
30
Role of cytokines in the pathogenesis of the euthyroid sick syndrome. ( 9678522 )
1998
31
[Euthyroid sick syndrome: recent physiopathologic findings]. ( 9793151 )
1998
32
Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. ( 9591009 )
1998
33
Euthyroid sick syndrome: an overview. ( 9086580 )
1997
34
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? ( 9024211 )
1997
35
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. ( 9349590 )
1997
36
Transiently decreased sialylation of thyrotropin (TSH) in a patient with the euthyroid sick syndrome. ( 9086572 )
1997
37
Euthyroid sick syndrome in psychiatric inpatients. ( 8959294 )
1996
38
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. ( 11862240 )
1996
39
Nonthyroidal illness syndrome or euthyroid sick syndrome? ( 15251561 )
1996
40
Reverse T3 does not reliably differentiate hypothyroid sick syndrome from euthyroid sick syndrome. ( 8808092 )
1995
41
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome. ( 7834406 )
1995
42
Cardiopulmonary bypass temperature does not affect postoperative euthyroid sick syndrome? ( 7497757 )
1995
43
Distinguishing hypothyroxinemia due to euthyroid sick syndrome from pituitary insufficiency. ( 7960686 )
1994
44
Possible etiology for euthyroid sick syndrome. ( 8455465 )
1993
45
Heart transplantation, euthyroid sick syndrome, and triiodothyronine replacement. ( 1515440 )
1992
46
Plasma selenium concentrations in patients with euthyroid sick syndrome. ( 1526030 )
1992
47
Euthyroid sick syndrome in type I diabetes mellitus in children and adolescents. ( 1867879 )
1991
48
Euthyroid sick syndrome in children with acute viral hepatitis A. ( 1867890 )
1991
49
The euthyroid sick syndrome. ( 1776598 )
1991
50
Triiodothyronine replacement, the euthyroid sick syndrome, and organ transplantation. ( 1926432 )
1991

Variations for Euthyroid Sick Syndrome

Expression for Euthyroid Sick Syndrome

Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for Euthyroid Sick Syndrome

GO Terms for Euthyroid Sick Syndrome

Cellular components related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ALB IL1B IL6 NPPB POMC SERPINA7
2 extracellular space GO:0005615 9.1 ALB IL1B IL6 NPPB POMC SERPINA7

Biological processes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.32 IL1B IL6
2 positive regulation of interleukin-6 production GO:0032755 9.16 IL1B IL6
3 response to calcium ion GO:0051592 8.96 IL6
4 positive regulation of nitric oxide biosynthetic process GO:0045429 8.96 IL1B IL6
5 response to lipopolysaccharide GO:0032496 8.62 IL1B IL6

Sources for Euthyroid Sick Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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