MCID: ETH004
MIFTS: 31

Euthyroid Sick Syndrome malady

Endocrine diseases category

Aliases & Classifications for Euthyroid Sick Syndrome

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Sources:
10Disease Ontology, 12DISEASES, 47Novoseek, 65UMLS, 36MeSH, 59SNOMED-CT, 29ICD9CM
See all sources

Aliases & Descriptions for Euthyroid Sick Syndrome:

Name: Euthyroid Sick Syndrome 10 12
Euthyroid Sick Syndromes 47 65 36
 
Sick-Euthyroid Syndrome 10


Classifications:



External Ids:

Disease Ontology10 DOID:2856
MeSH36 D005067
SNOMED-CT59 237542005
ICD9CM29 790.94

Summaries for Euthyroid Sick Syndrome

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Wikipedia:68 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), thyroid allostasis in critical illness,... more...

MalaCards based summary: Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to diabetic ketoacidosis and thyroiditis. An important gene associated with Euthyroid Sick Syndrome is IL6 (Interleukin 6), and among its related pathways are Malaria and Legionellosis. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Related Diseases for Euthyroid Sick Syndrome

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Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic ketoacidosis30.5IL1B, IL6
2thyroiditis10.6
3hypothyroidism10.5
4myocardial infarction10.2
5child syndrome10.2
6acute myocardial infarction10.2
7burns10.2
8congestive heart failure10.2
9hepatitis10.2
10cushing's syndrome10.2
11hepatitis a10.2
12nephrotic syndrome10.2
13spotted fever10.2
14thyroid gland disease10.2
15viral hepatitis10.2
16xanthomatosis10.2
17kid syndrome10.2
18head injury10.2
19mediterranean spotted fever10.2
20dystonia 410.2ALB, SERPINA7
21colon lymphoma10.2ALB, SERPINA7
22hereditary night blindness10.2IL6, SERPINA7
23acinic cell breast carcinoma10.2ALB, IL6
24chronic tubotympanic suppurative otitis media10.2ALB, IL6
25hemorrhagic proctocolitis10.1ALB, IL6
26ulcer of lower limbs10.1ALB, IL6
27fallopian tube transitional cell carcinoma10.1ALB, IL6
28idiopathic progressive polyneuropathy10.1ALB, IL6
29brain ischemia10.1ALB, IL6
30pseudohermaphroditism10.1ALB, IL6
31intraocular lymphoma10.1ALB, IL6
32transvestism10.1IL6, SERPINA7
33clonorchiasis10.1ALB, IL6
34microphthalmia10.1ALB, IL6
35calpainopathy10.1ALB, IL1B
36fasciolopsiasis10.1ALB, IL1B
37cranial nerve disease10.1ALB, IL6
38dentin dysplasia10.1ALB, IL6
39focal chorioretinitis10.1ALB, IL6
40mature b-cell neoplasm10.1ALB, IL6
41adiposis dolorosa10.1ALB, IL6
42plantar nerve lesion10.1IL1B, IL6
43humero-ulnar synostosis10.1IL1B, IL6
44larynx sarcoma10.1IL1B, IL6
45wissler's syndrome10.1IL1B, IL6
46acute allergic serous otitis media10.1ALB, IL1B
47chorioamnionitis10.1IL1B, IL6
48glossopharyngeal nerve disease10.1IL1B, IL6
49intermediate cell type choroid melanoma10.1IL1B, IL6
50fallopian tube cystadenofibroma10.1IL1B, IL6

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to euthyroid sick syndrome

Symptoms for Euthyroid Sick Syndrome

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Drugs & Therapeutics for Euthyroid Sick Syndrome

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Drugs for Euthyroid Sick Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcysteineapprovedPhase 4280616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
 
Flumucetin
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Mercapturic acid
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
Sodium 2-acetamido-3-mercaptopropionate
2
Magnesium oxideapprovedPhase 4491309-48-414792
Synonyms:
 
Magmitt
Magnesium Oxide
3Calcium, DietaryPhase 43529
4N-monoacetylcystinePhase 4280
5ExpectorantsPhase 4320
6
Hydroxocobalaminapproved21713422-51-011953898, 5460373, 44475014
Synonyms:
13422-51-0
22465-48-1
78091-12-0
8017-22-9
Acti-B12
AlphaRedisol
AlphaRedisol (TN)
Axion
Axlon
Benzimidazolyl ribofuranosyl phosphate deriv.
C08230
C62H85CoN13O15P
CHEBI:27786
CHEMBL1200742
CHEMBL235822
CID11622291
CID11953898
CID5460373
CID6433575
CID6474319
Ciplamin H
Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-hydroxocobamide
Cobalex
Cobalin H
Cobinamide dihydroxide dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-a-D-ribofuranosylbenzimidazole inner salt
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole inner salt
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosylbenzimidazole inner salt
Cobinamide, Co-hydroxy-, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3)
Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3)
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono (inner salt), 3'- ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Cobinamide, hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Codroxomin
Cyanokit
Cyanokit (TN)
D01027
DB00200
Depogamma
Docclan
Docelan
Docelvita
Docevita
Droxomin
Ducobee Hy
Ducobee-Hy
Duradoce
Duralta-12
EINECS 236-533-2
HSDB 3342
HYDROXOCOBALAMIN
Hidroxocobalamina
Hidroxocobalamina [INN-Spanish]
 
Hydro Cobex
Hydrobamine
Hydrocobalamin
Hydrogrisevit
Hydrovit
Hydroxocobalamin
Hydroxocobalamin (JAN/USP/INN)
Hydroxocobalamin Vitamin B12
Hydroxocobalamin [USAN:INN:BAN:JAN]
Hydroxocobalamin acetate
Hydroxocobalamin monohydrochloride
Hydroxocobalamin(alkaline soln.), OH- replaces CN- in Cyanocobalamin)
Hydroxocobalaminacetat
Hydroxocobalamine
Hydroxocobalamine [INN-French]
Hydroxocobalaminum
Hydroxocobalaminum [INN-Latin]
Hydroxocobemine
Hydroxomin
Hydroxy Cobal
Hydroxy vitamin B12
Hydroxycob(lll)alamin
Hydroxycobalamin
Hydroxycobalamine
Hyxobamine
Idrogrisevit
Idrossocobalamina
Idrossocobalamina [DCIT]
LS-54607
Lyovit-H
Neo-Betalin 12
Neo-cytamen
Neo-macrabin
Neo-rojamin
OH-Cbl
OH-Duphar
Ohb12
Oxobemin
Oxolamine (arcum)
Primabalt RP
Redisol-H
S1668_Selleck
Sytobex-H
UNII-Q40X8H422O
Vibeden
Vitadurin
Vitamin B(sub 12a)
Vitamin B-12b
Vitamin B12a
Vitamin B12b
a-(5,6-Dimethylbenzimidazolyl)hydroxocobamide
alpha Cobione
alpha-(5,6-Dimethylbenzimidazolyl)hydroxocobamide
vitamin B-12b
7
Cyanocobalaminapproved, nutraceutical21768-19-944176380, 44176380, 5462245
Synonyms:
Anacobin
Bedoz
Berocca PN
Berubigen
Betalin 12
Betalin 12 Crystalline
Betaline-12
Betolvex
Bevidox
Bevidox concentrate
Biocobalamine
Byladoce
Cabadon m
Cernevit-12
Cobadoce forte
Cobalin
Cobavite
Cobex
Cobolin-M
Copharvit 5000
Covit
Crystamin
Crystamine
Crysti-12
Crystimin
Crystwel
Cyano-B12
Cyanobalamin concentrate
Cyanocob(III)alamin
Cyanocobalamin
Cyanocobalamin (JP15/USP)
Cyanocobalamin Co 57 Schilling Test Kit
Cyanocobalamine
Cyanocobalmin
Cyanoject
Cycobemin
Cycolamin
Cykobemin
Cykobeminet
Cyomin
Cyredin
Cytacon
Cytamen
Cytobion
Depinar
Dicopac
Dicopac Kit
Dimethylbenzimidazoylcobamide
Distivit
Docemine
Docibin
Docivit
Dodecabee
Dodecavite
Dodex
Duodecibin
Embiol
Emociclina
Eritrone
 
Erycytol
Erythrotin
Euhaemon
Extrinsic factor
Factor II
Fermin
Fresmin
Hemomin
Hepagon
Hepavis
Hepcovite
Hylugel plus
Infuvite Pediatric
Lactobacillus lactis dorner factor
M.V.I. Pediatric
Macrabin
Megabion
Megalovel
Milbedoce
Millevit
Nagravon
Nascobal
Nascobal (TN)
Neuroforte-R
Normocytin
Novidroxin
Pernaemon
Pernaevit
Pernipuron
Plecyamin
Poyamin
Primabalt
Rebramin
Redamina
Redisol
Rhodacryst
Rubesol
Rubivite
Rubramin
Rubramin PC
Rubratope-57 Kit
Rubratope-60 Kit
Rubripca
Rubrocitol
Ruvite
Shovite
Sytobex
Vi-Twel
Vibal
Vibalt
Vibisone
Virubra
Vita-rubra
Vitabee 12
Vitamin B12
Vitamin B12 Preparation
Vitamin B12 complex
Vitaped
Vitarubin
Vitral
vitamine b12
8Vitamin B Complex2775
9Vitamin B 12224
10Vitamin B12Nutraceutical217
11
CobalaminNutraceutical21713408-78-16438156
Synonyms:
5,6-Dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole
5,6-Dimethyl-1-a-D-ribofuranosylbenzimidazole
5,6-Dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole
5,6-Dimethyl-1-alpha-delta-ribofuranosylbenzimidazole
Cob(III)alamin
Cobalamin (III)
Cobalamine
 
Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester
Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole
Hydroxomin
Rubivite
Rubratope-57
Rubratope-60
Ruvite
Vitamin B12
12
MethylcobalaminNutraceutical21713422-55-4
Synonyms:
Algobaz
Co-Methylcobalamin
Hitocobamin M
MeCbl
Mecobalamin
Methycobal
 
Methyl cobalamine
Methyl vitamin B12
Methyl-5,6-dimethylbenzimidazolylcobalamin
Methyl-B12
Methylcob(III)alamin
Methylcobalamin
Methylcobaz

Interventional clinical trials:

idNameStatusNCT IDPhase
1Levothyroxine for Children With Euthyroid Sick SyndromeCompletedNCT01631305Phase 4
2Effects of N-acetylcysteine on Low T3 SyndromeCompletedNCT01501110Phase 4
3Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in IndonesiaCompletedNCT02521168Phase 3
4Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in IndonesiaCompletedNCT02222532Phase 3
5Investigating the Role of EN in NTIS Among Fistula PatientsCompletedNCT02038504
6Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass SurgeryCompletedNCT01153360
7An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation EnteritisCompletedNCT02452073
8The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental ImplicationsRecruitingNCT01466023
9Approach to a Quantitative Follow-up of Non-thyroidal Illness SyndromeActive, not recruitingNCT00591032

Search NIH Clinical Center for Euthyroid Sick Syndrome


Cochrane evidence based reviews: Euthyroid Sick Syndromes

Genetic Tests for Euthyroid Sick Syndrome

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Anatomical Context for Euthyroid Sick Syndrome

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MalaCards organs/tissues related to Euthyroid Sick Syndrome:

33
Thyroid, Heart, Pituitary

Animal Models for Euthyroid Sick Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3ALB, IL1B, IL6, POMC
2MP:00053677.8ALB, DIO2, IL6, POMC

Publications for Euthyroid Sick Syndrome

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Articles related to Euthyroid Sick Syndrome:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Euthyroid sick syndrome in children with diabetic ketoacidosis. (25719594)
2015
2
Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis. (25154407)
2014
3
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. (23401683)
2013
4
Therapeutic effect of low-dose thyroxin in elderly patients with refractory heart failure and euthyroid sick syndrome]. (19778808)
2009
5
Is euthyroid sick syndrome a defensive mechanism against oxidative stress? (18524495)
2008
6
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. (17356583)
2007
7
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. (16734083)
2006
8
Euthyroid sick syndrome in trauma patients with severe inflammatory response syndrome. (16533439)
2006
9
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. (16076941)
2005
10
Expression of euthyroid sick syndrome in postischaemic heart disease is related to increased cardiovascular mortality: new options for intervention?: Heart and hormones. (25696169)
2003
11
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? (15055468)
2003
12
Euthyroid sick syndrome in acute ischemic syndromes. (12463624)
2002
13
Euthyroid sick syndrome. (12005007)
2002
14
Euthyroid sick syndrome in children with Hodgkin disease. (11293290)
2001
15
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. (10913935)
2000
16
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. (14564609)
2000
17
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. (10930442)
2000
18
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. (11138334)
2000
19
Euthyroid sick syndrome. (17016284)
2000
20
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. (14600974)
2000
21
Changes in metabolism of TRH in euthyroid sick syndrome. (10526245)
1999
22
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. (10660848)
1999
23
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. (10094108)
1999
24
Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. (9591009)
1998
25
Euthyroid sick syndrome: recent physiopathologic findings]. (9793151)
1998
26
Role of cytokines in the pathogenesis of the euthyroid sick syndrome. (9678522)
1998
27
Euthyroid sick syndrome: an overview. (9086580)
1997
28
Transiently decreased sialylation of thyrotropin (TSH) in a patient with the euthyroid sick syndrome. (9086572)
1997
29
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. (9349590)
1997
30
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? (9024211)
1997
31
Nonthyroidal illness syndrome or euthyroid sick syndrome? (15251561)
1996
32
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. (11862240)
1996
33
Euthyroid sick syndrome in psychiatric inpatients. (8959294)
1996
34
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome. (7834406)
1995
35
Cardiopulmonary bypass temperature does not affect postoperative euthyroid sick syndrome? (7497757)
1995
36
Distinguishing hypothyroxinemia due to euthyroid sick syndrome from pituitary insufficiency. (7960686)
1994
37
Possible etiology for euthyroid sick syndrome. (8455465)
1993
38
Plasma selenium concentrations in patients with euthyroid sick syndrome. (1526030)
1992
39
Heart transplantation, euthyroid sick syndrome, and triiodothyronine replacement. (1515440)
1992
40
Triiodothyronine replacement, the euthyroid sick syndrome, and organ transplantation. (1926432)
1991
41
Euthyroid sick syndrome in children with acute viral hepatitis A. (1867890)
1991
42
The euthyroid sick syndrome. (1853787)
1991
43
Euthyroid sick syndrome. (3919544)
1985
44
Malignant Mediterranean spotted fever. Report of a case with multiple organ failure, hypocalcemia, and euthyroid sick syndrome. (3839356)
1985
45
Familial hyperlipidaemia with multiple xanthomatosis and euthyroid sick syndrome. (6724629)
1984
46
Euthyroid sick syndrome. Association with urosepsis in an elderly man. (6371753)
1984
47
Euthyroid sick syndrome and free thyroxine assay. (6135016)
1983
48
Frequency of euthyroid sick syndrome as assessed by free thyroxine index and a direct free thyroxine assay. A limitation of FT4 assays. (6134145)
1983
49
Euthyroid sick syndrome and free thyroxine assay. (6135900)
1983
50
Euthyroid sick syndrome. (7295055)
1981

Variations for Euthyroid Sick Syndrome

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Expression for genes affiliated with Euthyroid Sick Syndrome

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Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for genes affiliated with Euthyroid Sick Syndrome

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GO Terms for genes affiliated with Euthyroid Sick Syndrome

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Cellular components related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.7ALB, IL1B, IL6, POMC, SERPINA7
2extracellular regionGO:00055767.4ALB, IL1B, IL6, POMC, SERPINA7

Biological processes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of interleukin-6 productionGO:00327559.9IL1B, IL6
2positive regulation of nitric oxide biosynthetic processGO:00454299.8IL1B, IL6
3response to peptide hormoneGO:00434349.8IL1B, SERPINA7
4response to heatGO:00094089.8IL1B, IL6
5positive regulation of T cell proliferationGO:00421029.8IL1B, IL6
6response to nutrient levelsGO:00316679.5IL6, SERPINA7
7agingGO:00075689.1IL1B, IL6, SERPINA7
8response to drugGO:00424938.8IL1B, IL6, SERPINA7

Sources for Euthyroid Sick Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet