MCID: ETH004
MIFTS: 36

Euthyroid Sick Syndrome malady

Categories: Endocrine diseases

Aliases & Classifications for Euthyroid Sick Syndrome

Aliases & Descriptions for Euthyroid Sick Syndrome:

Name: Euthyroid Sick Syndrome 12 14
Euthyroid Sick Syndromes 52 42 69
Sick-Euthyroid Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2856
ICD10 33 E07.81
ICD9CM 35 790.94
MeSH 42 D005067
NCIt 47 C113170
SNOMED-CT 64 237542005
UMLS 69 C0015190

Summaries for Euthyroid Sick Syndrome

MalaCards based summary : Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to myocardial infarction and thyroiditis. An important gene associated with Euthyroid Sick Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are Lung fibrosis and Photodynamic therapy-induced NF-kB survival signaling. The drugs Acetylcysteine and Magnesium oxide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related phenotype is neoplasm.

Wikipedia : 71 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), thyroid allostasis in critical illness,... more...

Related Diseases for Euthyroid Sick Syndrome

Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
id Related Disease Score Top Affiliating Genes
1 myocardial infarction 29.2 ALB IL1B IL6 NPPB
2 thyroiditis 10.3
3 ehlers-danlos syndrome, periodontal type 1 10.3 ALB SERPINA7
4 congenital nonspherocytic hemolytic anemia 10.2 ALB SERPINA7
5 mixed eosinophil-basophil adenoma 10.2 IL6 SERPINA7
6 shoulder impingement syndrome 10.2 ALB IL6
7 inner ear disease 10.2 ALB IL6
8 labyrinthine bilateral reactive loss 10.2 ALB IL6
9 broad ligament malignant neoplasm 10.2 DIO2 SERPINA7
10 fallopian tube serous adenocarcinoma 10.2 ALB IL6
11 cataract 10.2 ALB IL1B
12 hereditary alpha tryptasemia syndrome 10.2 ALB IL6
13 rosacea 10.2 ALB IL1B
14 oculomotor nerve paralysis 10.2 IL1B IL6
15 common peroneal nerve lesion 10.2 IL1B IL6
16 hyperlipoproteinemia type iv 10.2 ALB IL6
17 childhood electroclinical syndrome 10.2 IL1B IL6
18 anal paget's disease 10.2 IL1B IL6
19 laryngotracheoesophageal cleft type 2 10.2 IL1B IL6
20 bipolar i disorder 10.2 IL1B IL6
21 human immunodeficiency virus infectious disease 10.2 IL1B IL6
22 tinea capitis 10.2 IL1B IL6
23 bladder sarcoma 10.2 ALB IL6
24 measles 10.2 IL1B IL6
25 dextrocardia 10.2 IL1B IL6
26 bullous retinoschisis 10.2 IL1B IL6
27 carbuncle 10.2 IL1B IL6
28 hypoparathyroidism-retardation-dysmorphism syndrome 10.2 IL1B IL6
29 larynx leiomyoma 10.2 IL1B IL6
30 steroid dehydrogenase deficiency dental anomalies 10.2 IL1B IL6
31 gastric leiomyoma 10.2 IL1B IL6
32 acquired thrombocytopenia 10.2 IL1B IL6
33 benign neonatal seizures 10.2 IL1B IL6
34 plummer's disease 10.2 ALB IL6
35 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 10.2 IL1B IL6
36 gonococcal endophthalmia 10.1 IL1B IL6
37 allergic bronchopulmonary aspergillosis 10.1 ALB IL6
38 ectodermal dysplasia bartalos type 10.1 IL1B IL6
39 twin-to-twin transfusion syndrome 10.1 DIO2 IL1B
40 mineral metabolism disease 10.1 IL1B IL6
41 coenurosis 10.1 IL1B IL6
42 migraine with aura 10.1 IL1B IL6
43 isolated growth hormone deficiency 10.1 ALB IL1B
44 glandular cystitis 10.1 IL1B IL6
45 distal monosomy 14q 10.1 IL6 POMC
46 urea cycle disorder 10.1 IL1B IL6
47 autosomal recessive type iv ehlers-danlos syndrome 10.1 IL1B IL6
48 basal ganglia cerebrovascular disease 10.1 ALB POMC
49 bladder signet ring cell adenocarcinoma 10.1 IL1B IL6
50 urticaria 10.1 ALB IL1B

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to Euthyroid Sick Syndrome

Symptoms & Phenotypes for Euthyroid Sick Syndrome

MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 ALB IL1B IL6 POMC

Drugs & Therapeutics for Euthyroid Sick Syndrome

Drugs for Euthyroid Sick Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Magnesium oxide Approved Phase 4 1309-48-4 14792
3 N-monoacetylcystine Phase 4
4 Gastrointestinal Agents Phase 4
5 Hormones Phase 4,Phase 2
6 Antacids Phase 4
7 Expectorants Phase 4
8 Anti-Infective Agents Phase 4
9 Protective Agents Phase 4
10 Antidotes Phase 4
11 Respiratory System Agents Phase 4
12 Anti-Ulcer Agents Phase 4
13 Antiviral Agents Phase 4
14 Antioxidants Phase 4
15 Calcium, Dietary Phase 4
16 Anesthetics Phase 3,Phase 2
17 Central Nervous System Depressants Phase 3
18
Hydroxocobalamin Approved 13422-51-0 11953898 5460373 44475014
19
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
20 Hormone Antagonists
21 Hormones, Hormone Substitutes, and Hormone Antagonists
22 Vitamin B 12
23 Vitamin B Complex
24 Vitamins
25 Vitamin B12 Nutraceutical
26
Cobalamin Nutraceutical 13408-78-1 6438156
27
Methylcobalamin Experimental, Nutraceutical 13422-55-4

Interventional clinical trials:

(show all 13)
id Name Status NCT ID Phase
1 Levothyroxine for Children With Euthyroid Sick Syndrome Completed NCT01631305 Phase 4
2 Effects of N-acetylcysteine on Low T3 Syndrome Completed NCT01501110 Phase 4
3 Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02521168 Phase 3
4 Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia Completed NCT02222532 Phase 3
5 Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? Completed NCT01780584 Phase 2
6 Investigating the Role of EN in NTIS Among Fistula Patients Completed NCT02038504
7 Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery Completed NCT01153360
8 An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation Enteritis Completed NCT02452073
9 The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental Implications Completed NCT01466023
10 Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF) Completed NCT01481402
11 Feeding the Critically Ill During Phases of Altered Redox Status Recruiting NCT03085615
12 Approach to a Quantitative Follow-up of Non-thyroidal Illness Syndrome Active, not recruiting NCT00591032
13 Respiratory Muscle Function After Thyroid Hormone Replacement Therapy in Nonthyroidal Illness Syndrome Not yet recruiting NCT03157466

Search NIH Clinical Center for Euthyroid Sick Syndrome

Cochrane evidence based reviews: euthyroid sick syndromes

Genetic Tests for Euthyroid Sick Syndrome

Anatomical Context for Euthyroid Sick Syndrome

MalaCards organs/tissues related to Euthyroid Sick Syndrome:

39
Thyroid, Heart, Pituitary

Publications for Euthyroid Sick Syndrome

Articles related to Euthyroid Sick Syndrome:

(show top 50) (show all 61)
id Title Authors Year
1
Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome. ( 27737323 )
2016
2
Euthyroid Sick Syndrome. ( 27065175 )
2016
3
Euthyroid sick syndrome in children with diabetic ketoacidosis. ( 25719594 )
2015
4
Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis. ( 25154407 )
2014
5
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. ( 23401683 )
2013
6
Euthyroid sick syndrome and nutritional status are correlated with hyposelenemia in hemodialysis patients. ( 21786251 )
2011
7
[Therapeutic effect of low-dose thyroxin in elderly patients with refractory heart failure and euthyroid sick syndrome]. ( 19778808 )
2009
8
Is euthyroid sick syndrome a defensive mechanism against oxidative stress? ( 18524495 )
2008
9
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. ( 19007679 )
2008
10
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. ( 17356583 )
2007
11
Euthyroid sick syndrome in trauma patients with severe inflammatory response syndrome. ( 16533439 )
2006
12
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. ( 16734083 )
2006
13
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. ( 16076941 )
2005
14
Expression of euthyroid sick syndrome in postischaemic heart disease is related to increased cardiovascular mortality: new options for intervention?: Heart and hormones. ( 25696169 )
2003
15
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? ( 15055468 )
2003
16
Interferon-gamma administration does not affect human thyroid hormone metabolism in the post-surgical euthyroid sick syndrome. ( 12030601 )
2002
17
Euthyroid sick syndrome. ( 12005007 )
2002
18
Euthyroid sick syndrome in acute ischemic syndromes. ( 12463624 )
2002
19
Euthyroid sick syndrome in children with Hodgkin disease. ( 11293290 )
2001
20
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. ( 10913935 )
2000
21
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. ( 14564609 )
2000
22
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. ( 10930442 )
2000
23
Euthyroid sick syndrome. ( 17016284 )
2000
24
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. ( 11138334 )
2000
25
Euthyroid Sick Syndrome and the role of cytokines. ( 11704991 )
2000
26
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. ( 14600974 )
2000
27
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. ( 10660848 )
1999
28
Changes in metabolism of TRH in euthyroid sick syndrome. ( 10526245 )
1999
29
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. ( 10094108 )
1999
30
Role of cytokines in the pathogenesis of the euthyroid sick syndrome. ( 9678522 )
1998
31
[Euthyroid sick syndrome: recent physiopathologic findings]. ( 9793151 )
1998
32
Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. ( 9591009 )
1998
33
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? ( 9024211 )
1997
34
Euthyroid sick syndrome: an overview. ( 9086580 )
1997
35
Transiently decreased sialylation of thyrotropin (TSH) in a patient with the euthyroid sick syndrome. ( 9086572 )
1997
36
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. ( 9349590 )
1997
37
Nonthyroidal illness syndrome or euthyroid sick syndrome? ( 15251561 )
1996
38
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. ( 11862240 )
1996
39
Euthyroid sick syndrome in psychiatric inpatients. ( 8959294 )
1996
40
Reverse T3 does not reliably differentiate hypothyroid sick syndrome from euthyroid sick syndrome. ( 8808092 )
1995
41
Cardiopulmonary bypass temperature does not affect postoperative euthyroid sick syndrome? ( 7497757 )
1995
42
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome. ( 7834406 )
1995
43
Distinguishing hypothyroxinemia due to euthyroid sick syndrome from pituitary insufficiency. ( 7960686 )
1994
44
Possible etiology for euthyroid sick syndrome. ( 8455465 )
1993
45
Heart transplantation, euthyroid sick syndrome, and triiodothyronine replacement. ( 1515440 )
1992
46
Plasma selenium concentrations in patients with euthyroid sick syndrome. ( 1526030 )
1992
47
The euthyroid sick syndrome. ( 1776598 )
1991
48
The euthyroid sick syndrome. ( 1853787 )
1991
49
Euthyroid sick syndrome in type I diabetes mellitus in children and adolescents. ( 1867879 )
1991
50
Triiodothyronine replacement, the euthyroid sick syndrome, and organ transplantation. ( 1926432 )
1991

Variations for Euthyroid Sick Syndrome

Expression for Euthyroid Sick Syndrome

Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for Euthyroid Sick Syndrome

GO Terms for Euthyroid Sick Syndrome

Cellular components related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ALB IL1B IL6 NPPB POMC SERPINA7
2 extracellular space GO:0005615 9.1 ALB IL1B IL6 NPPB POMC SERPINA7

Biological processes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.16 IL1B IL6
2 positive regulation of interleukin-6 production GO:0032755 8.96 IL1B IL6
3 positive regulation of nitric oxide biosynthetic process GO:0045429 8.62 IL1B IL6

Sources for Euthyroid Sick Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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