MCID: ETH004
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Euthyroid Sick Syndrome malady

Summaries for Euthyroid Sick Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), non-thyroidal illness syndrome (NTIS) or... more...

MalaCards: Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to thyroiditis and hypothyroidism. An important gene associated with Euthyroid Sick Syndrome is DIO2 (deiodinase, iodothyronine, type II), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Selenium Pathway. The compounds ivig and warfarin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Euthyroid Sick Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM
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Aliases & Descriptions:

euthyroid sick syndrome 8 10
euthyroid sick syndromes 44 60
sick-euthyroid syndrome 8


External Ids:

Disease Ontology8 DOID:2856
MeSH34 D005067
SNOMED-CT56 237542005
ICD9CM27 790.94

Related Diseases for Euthyroid Sick Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.7TRH, POMC, SERPINA7
2hypothyroidism30.5TRH, THRSP, SERPINA7
3acute myocardial infarction30.2NPPB
4cushing's syndrome30.2POMC, TRH
5hepatitis30.2GPT, SERPINA7
6viral hepatitis30.2GPT
7myocardial infarction30.2NPPB, MGP
8diabetes mellitus30.2NPPB, MGP, POMC, IL1B, IL6, GPT
9burns10.2
10hepatitis a10.2
11congestive heart failure10.2
12epilepsy syndrome10.2
13spotted fever10.2
14xanthomatosis10.2
15multiple myeloma10.0IL6
16polyneuropathy10.0SERPINA7
17gout10.0IL1B
18interstitial lung disease10.0IL1B
19otitis media10.0IL1B
20adenocarcinoma10.0DIO2
21periodontal disease10.0IL6
22toxic shock syndrome10.0IL1B
23periodontitis10.0IL1B
24glaucoma10.0MGP
25sarcoidosis10.0IL1B
26encephalitis10.0IL1B
27thyroid cancer10.0TRH
28familial mediterranean fever10.0IL1B
29degenerative disc disease10.0IL1B
30klinefelter's syndrome10.0TRH
31respiratory failure10.0IL6, IL1B
32graves' disease10.0SERPINA7, DIO2
33anorexia nervosa10.0POMC
34brain edema10.0ALB
35dementia10.0TRH
36rheumatic fever10.0POMC
37arteriosclerosis10.0MGP
38thrombocytosis10.0IL6, IL1B
39diarrhea10.0ALB
40growth hormone deficiency10.0POMC
41polycystic ovary syndrome10.0POMC
42hyperhomocysteinemia10.0ALB
43poems syndrome10.0IL1B, IL6
44uremia10.0ALB
45rheumatoid arthritis10.0IL6, IL1B
46acute adrenal insufficiency10.0POMC
47varicose veins10.0ALB
48ovarian hyperstimulation syndrome10.0ALB
49thyroid adenoma10.0DIO2, SERPINA7
50osteoarthritis10.0IL6, IL1B

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to euthyroid sick syndrome

Clinical Features for Euthyroid Sick Syndrome

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Drugs & Therapeutics for Euthyroid Sick Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Euthyroid Sick Syndrome

Drug clinical trials:

Search ClinicalTrials for Euthyroid Sick Syndrome

Search NIH Clinical Center for Euthyroid Sick Syndrome

Search CenterWatch for Euthyroid Sick Syndrome

Genetic Tests for Euthyroid Sick Syndrome

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Anatomical Context for Euthyroid Sick Syndrome

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32MalaCards
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MalaCards organs/tissues related to Euthyroid Sick Syndrome:

32
Thyroid, Heart, Pituitary

Animal Models for Euthyroid Sick Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9DIO1, DIO2, MGP, POMC
2MP:00020068.7ALB, IL6, IL1B, FRK, POMC
3MP:00053766.9ALB, DIO1, DIO2, TRH, POMC, FRK

Publications for Euthyroid Sick Syndrome

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50PubMed
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Articles related to Euthyroid Sick Syndrome:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
The potential association of later initiation of oral/enteral nutrition on euthyroid sick syndrome in burn patients. (23401683)
2013
2
Euthyroid sick syndrome and nutritional status are correlated with hyposelenemia in hemodialysis patients. (21786251)
2011
3
Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. (19007679)
2008
4
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria. (17356583)
2007
5
Euthyroid sick syndrome in dogs with idiopathic epilepsy before treatment with anticonvulsant drugs. (16734083)
2006
6
Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins. (16076941)
2005
7
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment? (15055468)
2003
8
Euthyroid sick syndrome in acute ischemic syndromes. (12463624)
2002
9
Euthyroid sick syndrome. (12005007)
2002
10
Interferon-gamma administration does not affect human thyroid hormone metabolism in the post-surgical euthyroid sick syndrome. (12030601)
2002
11
Euthyroid sick syndrome in children with Hodgkin disease. (11293290)
2001
12
Involvement of circulating interleukin-6 and its receptor in the development of euthyroid sick syndrome in patients with acute myocardial infarction. (10913935)
2000
13
Thiopental intensifies the euthyroid sick syndrome after cardiopulmonary resuscitation. (14564609)
2000
14
A potential role of activated NF-kappa B in the pathogenesis of euthyroid sick syndrome. (10930442)
2000
15
Euthyroid sick syndrome and inhibitory effect of sera on the activity of thyroid 5'-deiodinase in systemic sclerosis. (11138334)
2000
16
Euthyroid sick syndrome. (17016284)
2000
17
Euthyroid sick syndrome in head injury patients compared with Glasgow Coma and Outcome Scales. (14600974)
2000
18
Euthyroid Sick Syndrome and the role of cytokines. (11704991)
2000
19
Changes in metabolism of TRH in euthyroid sick syndrome. (10526245)
1999
20
Activation of the hypothalamo-pituitary-adrenal axis in response to septic or non-septic diseases--implications for the euthyroid sick syndrome. (10660848)
1999
21
Characteristics of recovery from the euthyroid sick syndrome induced by tumor necrosis factor alpha in cancer patients. (10094108)
1999
22
Euthyroid sick syndrome, associated endocrine abnormalities, and outcome in elderly patients undergoing emergency operation. (9591009)
1998
23
Euthyroid sick syndrome: recent physiopathologic findings]. (9793151)
1998
24
Euthyroid sick syndrome: an overview. (9086580)
1997
25
Transiently decreased sialylation of thyrotropin (TSH) in a patient with the euthyroid sick syndrome. (9086572)
1997
26
Transiently decreased sialylation of thyrotropin in a patient with the euthyroid sick syndrome. (9349590)
1997
27
Clinical review 86: Euthyroid sick syndrome: is it a misnomer? (9024211)
1997
28
Subclinical Hypothyroidism and Euthyroid Sick Syndrome in Patients with Moderate-to-Severe Congestive Heart Failure. (11862240)
1996
29
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome. (7834406)
1995
30
Reverse T3 does not reliably differentiate hypothyroid sick syndrome from euthyroid sick syndrome. (8808092)
1995
31
Distinguishing hypothyroxinemia due to euthyroid sick syndrome from pituitary insufficiency. (7960686)
1994
32
Possible etiology for euthyroid sick syndrome. (8455465)
1993
33
Plasma selenium concentrations in patients with euthyroid sick syndrome. (1526030)
1992
34
Heart transplantation, euthyroid sick syndrome, and triiodothyronine replacement. (1515440)
1992
35
Triiodothyronine replacement, the euthyroid sick syndrome, and organ transplantation. (1926432)
1991
36
Euthyroid sick syndrome in children with acute viral hepatitis A. (1867890)
1991
37
The euthyroid sick syndrome. (1853787)
1991
38
Euthyroid sick syndrome in type I diabetes mellitus in children and adolescents. (1867879)
1991
39
The euthyroid sick syndrome. (1776598)
1991
40
TSH secretion in Cushing's syndrome: relation to glucocorticoid excess, diabetes, goitre, and the 'sick euthyroid syndrome'. (2128925)
1990
41
Euthyroid sick syndrome. (3919544)
1985
42
Malignant Mediterranean spotted fever. Report of a case with multiple organ failure, hypocalcemia, and euthyroid sick syndrome. (3839356)
1985
43
Familial hyperlipidaemia with multiple xanthomatosis and euthyroid sick syndrome. (6724629)
1984
44
Euthyroid sick syndrome. Association with urosepsis in an elderly man. (6371753)
1984
45
Euthyroid sick syndrome and free thyroxine assay. (6135016)
1983
46
Frequency of euthyroid sick syndrome as assessed by free thyroxine index and a direct free thyroxine assay. A limitation of FT4 assays. (6134145)
1983
47
Euthyroid sick syndrome and free thyroxine assay. (6135900)
1983
48
Euthyroid sick syndrome and free thyroxine assay. (6137682)
1983
49
Euthyroid sick syndrome. (7295055)
1981
50
Euthyroid sick syndrome. (714120)
1978

Genetic Variations for Euthyroid Sick Syndrome

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Expression for genes affiliated with Euthyroid Sick Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Euthyroid Sick Syndrome

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Pathways for genes affiliated with Euthyroid Sick Syndrome

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52R&D Systems, 37NCBI BioSystems Database
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Pathways related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0IL6, IL1B
28.9ALB, IL6, IL1B, DIO2, DIO1

Compounds for genes affiliated with Euthyroid Sick Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1ivig4410.5GPT
2warfarin44 49 11 2413.4MGP
3muramyl tripeptide phosphatidylethanolamine4410.3IL1B, IL6
4turpentine4410.3IL6, IL1B
5pentoxifylline44 1111.2NPPB
6prednisolone44 28 1112.1POMC, NPPB
7forskolin44 49 1112.0POMC, NPPB
8iodide44 2411.0DIO1, SERPINA7, DIO2
9cycloheximide4410.0DIO2, TRH
10neopterin449.7IL6, GPT, IL1B
11bucillamine449.7IL6, IL1B
12rosuvastatin44 49 28 1112.6IL6, GPT, ALB
13hepaplastin449.6GPT, ALB
14ibuprofen44 28 49 11 2413.6IL6, ALB, IL1B
15corticosterone44 59 2411.6SERPINA7, IL1B, POMC, GPT
16Liothyronine11 2410.6DIO1, ALB, SERPINA7, DIO2
17iodine44 2410.6DIO2, TRH, SERPINA7, DIO1
18sevoflurane44 1110.5GPT, NPPB, ALB
19methimazole44 2 1111.5SERPINA7, POMC, TRH, DIO2
20pyridoxal 5-phosphate449.5POMC, ALB, GPT
21vitamin d449.5MGP, NPPB, IL6, GPT
22ribonucleic acid449.5POMC, IL1B, DIO2, SERPINA7
23hydrocortisone44 2 59 1112.5POMC, TRH, IL6, IL1B
24calcitriol44 59 11 2412.5ALB, IL6, IL1B, MGP
25hyaluronic acid44 2410.4ALB, IL1B, IL6, GPT
26aspirin44 49 28 2412.4NPPB, POMC, IL1B, SERPINA7
27naloxone44 49 28 1112.4ALB, POMC, TRH
28pioglitazone44 49 28 1112.4GPT, IL6, NPPB
29pravastatin44 49 28 11 2413.4GPT, NPPB, IL6
30diazepam44 49 28 1112.3POMC, ALB, TRH
31spironolactone49 44 59 28 1113.3NPPB, POMC, SERPINA7, ALB
32methotrexate44 49 1111.3GPT, IL6, IL1B, ALB
33furosemide44 49 59 28 11 2414.3NPPB, POMC, SERPINA7, ALB
34rosiglitazone44 49 28 11 2413.2NPPB, GPT, ALB, IL6
35acth449.2POMC, IL1B, IL6, TRH, SERPINA7
36urea44 11 2411.1GPT, SERPINA7, ALB, TRH
37haloperidol44 28 2 49 1113.1NPPB, TRH, POMC, GPT
38indomethacin44 59 28 1112.0ALB, POMC, NPPB, IL6, IL1B
39dopamine44 28 11 2411.9TRH, NPPB, DIO2, POMC, SERPINA7
40dexamethasone44 49 28 1111.7IL6, TRH, IL1B, POMC, DIO2, NPPB
41alanine448.7POMC, DIO2, ALB, SERPINA7, GPT, IL6
42estradiol44 11 2410.7ALB, SERPINA7, POMC, NPPB, TRH
43cholesterol44 28 11 2411.6SERPINA7, IL6, ALB, GPT, MGP
44creatinine448.6ALB, SERPINA7, GPT, NPPB, POMC, IL6
45testosterone44 59 11 2411.5TRH, SERPINA7, IL6, POMC, NPPB, ALB
46estrogen448.5NPPB, DIO2, MGP, TRH, POMC, IL6
47triiodothyronine448.1DIO2, DIO1, SERPINA7, POMC, NPPB, THRSP
48lipid447.8THRSP, SERPINA7, IL6, GPT, ALB, NPPB
49glucose447.2POMC, IL6, THRSP, ALB, TRH, DIO2
50thyroxine44 248.2TRH, DIO2, NPPB, GPT, THRSP, SERPINA7

GO Terms for genes affiliated with Euthyroid Sick Syndrome

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16Gene Ontology
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Cellular components related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:0301419.3IL1B, POMC, TRH
2extracellular spaceGO:0056158.2ALB, SERPINA7, IL6, IL1B, POMC, NPPB
3extracellular regionGO:0055767.5NPPB, TRH, POMC, IL1B, IL6, SERPINA7

Biological processes related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:0424469.8DIO2, DIO1
2response to corticosterone stimulusGO:0514129.7SERPINA7, TRH
3thyroid hormone generationGO:0065909.6DIO2, DIO1

Molecular functions related to Euthyroid Sick Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1selenium bindingGO:0084309.9DIO2, DIO1
2thyroxine 5-deiodinase activityGO:0048009.8DIO2, DIO1
3pyridoxal phosphate bindingGO:0301708.4ALB, GOT1L1, GPT

Products for genes affiliated with Euthyroid Sick Syndrome

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Sources for Euthyroid Sick Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet