MCID: ETH004
MIFTS: 34

Euthyroid Sick Syndrome malady

Category: Endocrine diseases

Aliases & Classifications for Euthyroid Sick Syndrome

About this section

Aliases & Descriptions for Euthyroid Sick Syndrome:

Name: Euthyroid Sick Syndrome 10 12
Euthyroid Sick Syndromes 47 36 65
 
Sick-Euthyroid Syndrome 10

Classifications:



External Ids:

Disease Ontology10 DOID:2856
ICD1027 E07.81
ICD9CM29 790.94
SNOMED-CT59 237542005
MeSH36 D005067
NCIt42 C113170
UMLS65 C0015190

Summaries for Euthyroid Sick Syndrome

About this section
Wikipedia:68 Euthyroid sick syndrome (ESS), sick euthyroid syndrome (SES), thyroid allostasis in critical illness,... more...

MalaCards based summary: Euthyroid Sick Syndrome, also known as euthyroid sick syndromes, is related to pituitary adenoma and hepatitis. An important gene associated with Euthyroid Sick Syndrome is IL6 (Interleukin 6), and among its related pathways are Malaria and Legionellosis. Affiliated tissues include thyroid, placenta and liver, and related mouse phenotypes are tumorigenesis and renal/urinary system.

Related Diseases for Euthyroid Sick Syndrome

About this section

Diseases related to Euthyroid Sick Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary adenoma30.3POMC, SERPINA7
2hepatitis10.4
3dystonia 410.3ALB, SERPINA7
4euthyroid sick syndrome10.3ALB, SERPINA7
5sarcoma10.3
6hepatitis e10.3
7critical illness polyneuropathy10.2ALB, IL6
8hidrocystoma10.2IL6, SERPINA7
9scrotum squamous cell carcinoma10.2ALB, IL6
10neonatal diabetes mellitus10.2ALB, IL6
11brain ischemia10.2ALB, IL6
12retroperitoneal lymphoma10.2ALB, IL6
13conjunctivochalasis10.2ALB, IL6
14biliary atresia10.2ALB, IL6
15dentin dysplasia10.2ALB, IL6
16ileitis10.2ALB, IL1B
17fat necrosis of breast10.2ALB, IL6
18alexia10.2ALB, IL6
19alcoholic liver cirrhosis10.2ALB, IL6
20pneumoconiosis10.2ALB, IL6
21plantar nerve lesion10.1IL1B, IL6
22corneal abscess10.1IL1B, IL6
23peyronie's disease10.1DIO2, IL1B
24mammary paget's disease10.1IL1B, IL6
25lujo hemorrhagic fever10.1IL1B, IL6
26neonatal period electroclinical syndrome10.1IL1B, IL6
27residual stage angle-closure glaucoma10.1IL1B, IL6
28granulomatous amebic encephalitis10.1IL1B, IL6
29refractory plasma cell neoplasm10.1IL1B, IL6
30optic neuritis10.1IL1B, IL6
31chronic monocytic leukemia10.1IL1B, IL6
32dermoid cyst of ovary10.1ALB, IL6
33skin conditions10.1IL1B, IL6
34postsurgical hypothyroidism10.1IL1B, IL6
35eyelid neoplasm10.1IL1B, IL6
36human granulocytic anaplasmosis10.1IL1B, IL6
37rubeosis iridis10.1IL1B, IL6
38ureteral disease10.1IL1B, IL6
39large intestine lipoma10.1IL1B, IL6
40duodenum cancer10.1IL1B, IL6
41cystic echinococcosis10.1IL1B, IL6
42asthma10.1
43smith-lemli-opitz syndrome10.1
44kawasaki disease10.1
45pulmonary hypertension10.1
46brain injury10.1
47hepatitis b10.1
48traumatic brain injury10.1
49sleep apnea10.1
50obstructive sleep apnea10.1

Graphical network of the top 20 diseases related to Euthyroid Sick Syndrome:



Diseases related to euthyroid sick syndrome

Symptoms for Euthyroid Sick Syndrome

About this section

Drugs & Therapeutics for Euthyroid Sick Syndrome

About this section

Drugs for Euthyroid Sick Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Magnesium oxideapprovedPhase 4581309-48-414792
Synonyms:
 
Magmitt
Magnesium Oxide
2
AcetylcysteineapprovedPhase 4293616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
3N-monoacetylcystinePhase 4293
4Calcium, DietaryPhase 44678
5Respiratory System AgentsPhase 43931
6HormonesPhase 411748
7Protective AgentsPhase 45651
8Anti-Infective AgentsPhase 417220
9ExpectorantsPhase 4337
10AntioxidantsPhase 42442
11Antiviral AgentsPhase 48071
12AnestheticsPhase 37385
13
Hydroxocobalaminapproved22713422-51-011953898, 5460373, 44475014
Synonyms:
13422-51-0
22465-48-1
78091-12-0
8017-22-9
Acti-B12
AlphaRedisol
AlphaRedisol (TN)
Axion
Axlon
Benzimidazolyl ribofuranosyl phosphate deriv.
C08230
C62H85CoN13O15P
CHEBI:27786
CHEMBL1200742
CHEMBL235822
CID11622291
CID11953898
CID5460373
CID6433575
CID6474319
Ciplamin H
Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-hydroxocobamide
Cobalex
Cobalin H
Cobinamide dihydroxide dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-a-D-ribofuranosylbenzimidazole inner salt
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole inner salt
Cobinamide hydroxide phosphate 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosylbenzimidazole inner salt
Cobinamide, Co-hydroxy-, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3)
Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole-kappaN3)
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono (inner salt), 3'- ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono(inner salt), 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Cobinamide, hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole
Codroxomin
Cyanokit
Cyanokit (TN)
D01027
DB00200
Depogamma
Docclan
Docelan
Docelvita
Docevita
Droxomin
Ducobee Hy
Ducobee-Hy
Duradoce
Duralta-12
EINECS 236-533-2
HSDB 3342
HYDROXOCOBALAMIN
Hidroxocobalamina
Hidroxocobalamina [INN-Spanish]
 
Hydro Cobex
Hydrobamine
Hydrocobalamin
Hydrogrisevit
Hydrovit
Hydroxocobalamin
Hydroxocobalamin (JAN/USP/INN)
Hydroxocobalamin Vitamin B12
Hydroxocobalamin [USAN:INN:BAN:JAN]
Hydroxocobalamin acetate
Hydroxocobalamin monohydrochloride
Hydroxocobalamin(alkaline soln.), OH- replaces CN- in Cyanocobalamin)
Hydroxocobalaminacetat
Hydroxocobalamine
Hydroxocobalamine [INN-French]
Hydroxocobalaminum
Hydroxocobalaminum [INN-Latin]
Hydroxocobemine
Hydroxomin
Hydroxy Cobal
Hydroxy vitamin B12
Hydroxycob(lll)alamin
Hydroxycobalamin
Hydroxycobalamine
Hyxobamine
Idrogrisevit
Idrossocobalamina
Idrossocobalamina [DCIT]
LS-54607
Lyovit-H
Neo-Betalin 12
Neo-cytamen
Neo-macrabin
Neo-rojamin
OH-Cbl
OH-Duphar
Ohb12
Oxobemin
Oxolamine (arcum)
Primabalt RP
Redisol-H
S1668_Selleck
Sytobex-H
UNII-Q40X8H422O
Vibeden
Vitadurin
Vitamin B(sub 12a)
Vitamin B-12b
Vitamin B12a
Vitamin B12b
a-(5,6-Dimethylbenzimidazolyl)hydroxocobamide
alpha Cobione
alpha-(5,6-Dimethylbenzimidazolyl)hydroxocobamide
vitamin B-12b
14
Cyanocobalaminapproved, nutraceutical22768-19-944176380
Synonyms:
Anacobin
Bedoz
Berocca PN
Berubigen
Betalin 12
Betalin 12 Crystalline
Betaline-12
Betolvex
Bevidox
Bevidox concentrate
Biocobalamine
Byladoce
Cabadon m
Cernevit-12
Cobadoce forte
Cobalin
Cobavite
Cobex
Cobolin-M
Copharvit 5000
Covit
Crystamin
Crystamine
Crysti-12
Crystimin
Crystwel
Cyano-B12
Cyanobalamin concentrate
Cyanocob(III)alamin
Cyanocobalamin
Cyanocobalamin (JP15/USP)
Cyanocobalamin Co 57 Schilling Test Kit
Cyanocobalamine
Cyanocobalmin
Cyanoject
Cycobemin
Cycolamin
Cykobemin
Cykobeminet
Cyomin
Cyredin
Cytacon
Cytamen
Cytobion
Depinar
Dicopac
Dicopac Kit
Dimethylbenzimidazoylcobamide
Distivit
Docemine
Docibin
Docivit
Dodecabee
Dodecavite
Dodex
Duodecibin
Embiol
Emociclina
Eritrone
 
Erycytol
Erythrotin
Euhaemon
Extrinsic factor
Factor II
Fermin
Fresmin
Hemomin
Hepagon
Hepavis
Hepcovite
Hylugel plus
Infuvite Pediatric
Lactobacillus lactis dorner factor
M.V.I. Pediatric
Macrabin
Megabion
Megalovel
Milbedoce
Millevit
Nagravon
Nascobal
Nascobal (TN)
Neuroforte-R
Normocytin
Novidroxin
Pernaemon
Pernaevit
Pernipuron
Plecyamin
Poyamin
Primabalt
Rebramin
Redamina
Redisol
Rhodacryst
Rubesol
Rubivite
Rubramin
Rubramin PC
Rubratope-57 Kit
Rubratope-60 Kit
Rubripca
Rubrocitol
Ruvite
Shovite
Sytobex
Vi-Twel
Vibal
Vibalt
Vibisone
Virubra
Vita-rubra
Vitabee 12
Vitamin B12
Vitamin B12 Preparation
Vitamin B12 complex
Vitaped
Vitarubin
Vitral
vitamine b12
15Vitamins3857
16Vitamin B Complex2847
17Vitamin B 12227
18
MethylcobalaminNutraceutical22613422-55-4
Synonyms:
Algobaz
Co-Methylcobalamin
Hitocobamin M
MeCbl
Mecobalamin
Methycobal
 
Methyl cobalamine
Methyl vitamin B12
Methyl-5,6-dimethylbenzimidazolylcobalamin
Methyl-B12
Methylcob(III)alamin
Methylcobalamin
Methylcobaz
19Vitamin B12Nutraceutical227
20
CobalaminNutraceutical22713408-78-16438156
Synonyms:
5,6-Dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole
5,6-Dimethyl-1-a-D-ribofuranosylbenzimidazole
5,6-Dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole
5,6-Dimethyl-1-alpha-delta-ribofuranosylbenzimidazole
Cob(III)alamin
Cobalamin (III)
Cobalamine
 
Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester
Cobinamide ion(1+) dihydrogen phosphate (ester) inner salt 3'-ester with 5,6-dimethyl-1-alpha-delta-ribofuranosyl-1H-benzimidazole
Hydroxomin
Rubivite
Rubratope-57
Rubratope-60
Ruvite
Vitamin B12

Interventional clinical trials:

idNameStatusNCT IDPhase
1Levothyroxine for Children With Euthyroid Sick SyndromeCompletedNCT01631305Phase 4
2Effects of N-acetylcysteine on Low T3 SyndromeCompletedNCT01501110Phase 4
3Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in IndonesiaCompletedNCT02521168Phase 3
4Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in IndonesiaCompletedNCT02222532Phase 3
5Investigating the Role of EN in NTIS Among Fistula PatientsCompletedNCT02038504
6Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass SurgeryCompletedNCT01153360
7An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation EnteritisCompletedNCT02452073
8The Reduced Thyroid Function of the Premature Newborn: Relation With Molecular Changes in the Placenta and Maternal Thyroid Hormone Status and Neurodevelopmental ImplicationsRecruitingNCT01466023
9Approach to a Quantitative Follow-up of Non-thyroidal Illness SyndromeActive, not recruitingNCT00591032

Search NIH Clinical Center for Euthyroid Sick Syndrome


Cochrane evidence based reviews: euthyroid sick syndromes

Genetic Tests for Euthyroid Sick Syndrome

About this section

Anatomical Context for Euthyroid Sick Syndrome

About this section

MalaCards organs/tissues related to Euthyroid Sick Syndrome:

33
Thyroid, Placenta, Liver, Heart, Pancreas, T cells, Endothelial

Animal Models for Euthyroid Sick Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Euthyroid Sick Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2ALB, IL1B, IL6, POMC
2MP:00053678.1ALB, DIO2, IL6, POMC

Publications for Euthyroid Sick Syndrome

About this section

Articles related to Euthyroid Sick Syndrome:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Analysis of PRRT2 gene mutations in a Chinese family affected with paroxysmal kinesigenic dyskinesia]. (26829736)
2016
2
LASER VAPORIZATION IN VULVAR INTRAEPITHELIAL NEOPLASIA (VIN), VAGINAL INTRAEPITHELIAL NEOPLASIA (VAIN) AND CONDYLOMATA ACUMINATA: IGCS-0093 Vulvar and Vaginal Cancer. (25955950)
2015
3
Early Steroid-Induced Osteonecrosis of Rabbit Femoral Head and Panax notoginseng Saponins: Mechanism and Protective Effects. (25866538)
2015
4
Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma, and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus. (25761672)
2015
5
Src Family Kinase Inhibition as a Novel Strategy to Augment Melphalan-Based Regional Chemotherapy of Advanced Extremity Melanoma. (24281418)
2013
6
Small cell carcinoma of the anus in the setting of prior squamous dysplasia and carcinoma in situ. (23730521)
2013
7
A recommended method in order to interpret chest x-rays for diagnosing small size pneumothorax. (23724383)
2013
8
Congenital von Willebrand's disease and clinical hypothyroidism. (23171382)
2013
9
Understanding perceptions of genital herpes disclosure through analysis of an online video contest. (23702459)
2013
10
Outcomes of children with enterobacteriaceae bacteremia with reduced susceptibility to ceftriaxone: do the revised breakpoints translate to improved patient outcomes? (23470679)
2013
11
Health professionals in the process of vaccination against hepatitis B in two basic units of Belo Horizonte: a qualitative evaluation. (24142008)
2013
12
Oral squamous cell carcinoma of the mandibular region presenting as multiple discharging sinuses: imperative of magnetic resonance imaging and computerized tomography. (23930361)
2013
13
Chronic lymphocytic leukemia. (23303003)
2012
14
LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease. (22734645)
2012
15
Th17/Treg imbalance in patients with liver cystic echinococcosis. (22803774)
2012
16
Genetic polymorphism in a VEGF-independent angiogenesis gene ANGPT1 and overall survival of colorectal cancer patients after surgical resection. (22496856)
2012
17
Yoga for secondary prevention of coronary heart disease. (23235676)
2012
18
Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus. (22736314)
2012
19
Eruptive xanthomas as a cutaneous manifestation of hypertriglyceridemia: a case report. (21278899)
2011
20
Clinical and electrophysiological features of the 2007 Guillain-BarrAc syndrome epidemic in northeast China. (20589890)
2010
21
Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis. (19243472)
2010
22
Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice. (19931604)
2010
23
Paraplegia after mastoidectomy under general anesthesia. (19720254)
2009
24
Online spaced education to teach urology to medical students: a multi-institutional randomized trial. (18614145)
2009
25
Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene. (18505928)
2008
26
An infant case of intracranial peripheral-type primitive neuroectodermal tumor with long-term survival. (18095134)
2007
27
3.5-Year follow-up of intralesional cidofovir protocol for pediatric recurrent respiratory papillomatosis. (16919339)
2006
28
Cardiovascular and gastrointestinal effects of COX-2 inhibitors and NSAIDs: achieving a balance. (16168077)
2005
29
Effect of Climate Change on Lyme Disease Risk in North America. (19008966)
2005
30
Actin and microtubules in neurite initiation: are MAPs the missing link? (14598367)
2004
31
In vitro characterization of genetically modified embryonic stem cells as a therapy for murine mucopolysaccharidosis type IIIA. (14741188)
2004
32
Gastrointestinal hormone secretion after surgery in neonates with congenital intestinal anomalies during starvation and introduction of enteral nutrition. (14614708)
2003
33
Gemcitabine reverses cisplatin resistance: demonstration of activity in platinum- and multidrug-resistant ovarian and peritoneal carcinoma. (12504621)
2003
34
Rituximab in association with rapamycin for post-transplant lymphoproliferative disease treatment. (12664217)
2003
35
Family and parenting interventions for conduct disorder and delinquency: a meta-analysis of randomized controlled trials. (12448428)
2002
36
Influence of the risk factors for atherosclerosis on levels of soluble adhesion molecules and endothelial markers in peripheral vascular disease. (12195717)
2002
37
Follistatin inhibits the function of the oocyte-derived factor BMP-15. (11741284)
2001
38
Meningococcal infection in patients with the human immunodeficiency virus and acquired immunodeficiency syndrome. (11368827)
2001
39
A review of techniques for the investigation of otitis externa and otitis media. (11793879)
2001
40
Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes. (10873607)
2000
41
Aortitis with dissection complicating systemic lupus erythematosus. (8532387)
1995
42
Positron emission tomography with fluorine-18-fluorodeoxyglucose for the evaluation of therapeutic isolated regional limb perfusion in a patient with soft-tissue sarcoma. (8271067)
1994
43
Mast cells' contribution to the fibrosing alveolitis of the scleroderma lung. (8503561)
1993
44
Alveolar rhabdomyosarcoma - primary and recurrent metastatic tumor has chromosomal translocation t(2-13)(q37-q14), amplified N-myc and is tumorigenic in nude-mice. (21584508)
1992
45
Pro-alpha 1(XI) collagen. Structure of the amino-terminal propeptide and expression of the gene in tumor cell lines. (1690726)
1990
46
Hypohidrotic ectodermal dysplasia with hypothyroidism. (7463217)
1981
47
Letter: Antigenicity of S.M.O.N.-associated virus closely related to avian infectious laryngotracheitis virus. (4128758)
1973
48
True infective abacterial pyuria. (20997548)
1946
49
Pellagra Commission. (20891206)
1911
50
Pellagra. (18734879)
1910

Variations for Euthyroid Sick Syndrome

About this section

Expression for genes affiliated with Euthyroid Sick Syndrome

About this section
Search GEO for disease gene expression data for Euthyroid Sick Syndrome.

Pathways for genes affiliated with Euthyroid Sick Syndrome

About this section

GO Terms for genes affiliated with Euthyroid Sick Syndrome

About this section

Biological processes related to Euthyroid Sick Syndrome according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of nitric oxide biosynthetic processGO:004542910.1IL1B, IL6
2response to glucocorticoidGO:005138410.0IL1B, IL6
3wound healingGO:00420609.9IL1B, IL6
4positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.8IL1B, IL6
5positive regulation of ERK1 and ERK2 cascadeGO:00703749.7IL1B, IL6
6positive regulation of interleukin-6 productionGO:00327559.6IL1B, IL6
7response to heatGO:00094089.6IL1B, IL6
8positive regulation of apoptotic processGO:00430659.5IL1B, IL6
9cellular response to lipopolysaccharideGO:00712229.3IL1B, IL6

Sources for Euthyroid Sick Syndrome

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet