Ewing's Family of Tumors disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Ewing's Family of Tumors

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³²MalaCards
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MalaCards: Ewing's Family of Tumors, also known as extraosseous ewings sarcoma-primitive neuroepithelial tumor, is related to medulloblastoma and cerebral primitive neuroectodermal tumor. An important gene associated with Ewing's Family of Tumors is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are GPCR Pathway and Cyclins and Cell Cycle Regulation. The compounds butyrate and trastuzumab have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are integument and tumorigenesis.

Aliases & Classifications for Ewing's Family of Tumors

Sources:
⁴²NIH Rare Diseases, ⁶⁰UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Neuronal diseases, Bone diseases

Aliases & Descriptions:

ewing's family of tumors ⁴²

extraosseous ewings sarcoma-primitive neuroepithelial tumor ⁶⁰

primitive neuroectodermal tumor ⁴²

ewingâs tumor of bone ⁴²

extraosseous ewingâs ⁴²

ewing family of tumors ⁴²

askinâs tumor ⁴²

Related Diseases for Ewing's Family of Tumors

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Ewing's Family of Tumors family:

Ewing's Family Localized Tumor

Diseases related to Ewing's Family of Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 172)

id	Related Disease	Score	Top Affiliating Genes
1	medulloblastoma	31.4	CDK4, CDKN2B, DKK1
2	cerebral primitive neuroectodermal tumor	31.2	FLI1, EWSR1
3	retinoblastoma	30.8	ID2, ETV7, CDKN2B, CDK4, CDKN1B
4	rhabdomyosarcoma	30.6	CDK4, FLI1, EWSR1
5	embryonal rhabdomyosarcoma	30.6	CDK4, EWSR1
6	leukemia	30.6	ID2, TNFRSF10A, EWSR1, FLI1, ETV7, CDKN2B
7	synovial sarcoma	30.5	FLI1, EWSR1
8	gastrointestinal stromal tumor	30.5	KIT
9	endometrial carcinoma	30.5	ETV7, CDK4, CDKN1B
10	acute leukemia	30.5	TNFRSF10A, EWSR1, CDKN2B, KIT
11	angiosarcoma	30.2	FLI1
12	clear cell sarcoma	30.2	KIT, EWSR1
13	osteosarcoma	30.2	ID2, TNFRSF10A, DKK1, CDK4
14	malignant glioma	30.2	TNFRSF10A, CDKN2B, CDK4, CDKN1B
15	myeloid leukemia	30.2	KIT, CDK4, CDKN2B, ETV7, TNFRSF10A
16	bladder carcinoma	30.2	CDKN1B, CDK4, CDKN2B, TNFRSF10A
17	squamous cell carcinoma	30.2	TNFRSF10A, PSMD9, PKP1, ETV7, CDKN2B, CDK4
18	peripheral primitive neuroectodermal tumor	30.2	EWSR1, FLII, FLI1
19	sarcoma	30.2	KIT, CDK4, FLI1, EWSR1
20	melanoma	30.2	TNFRSF10A, EWSR1, FLI1, CDKN2B, CDK4, CDKN1B
21	supratentorial primitive neuroectodermal tumor	11.1
22	cerebritis	10.8
23	extraosseous ewings sarcoma-primitive neuroepithelial tumor	10.8
24	intracranial primitive neuroectodermal tumor	10.8
25	kidney sarcoma	10.7
26	atypical teratoid rhabdoid tumor	10.6
27	childhood medulloblastoma	10.6
28	bone ewing's sarcoma	10.6
29	extracranial arteriovenous malformation	10.5
30	cervicitis	10.5
31	cerebellopontine angle primitive neuroectodermal	10.5
32	neuronitis	10.5
33	extraosseous ewing's sarcoma	10.5
34	pineoblastoma	10.5
35	prostatitis	10.5
36	thyroiditis	10.5
37	unilateral retinoblastoma	10.4
38	localized peripheral primitive neuroectodermal tumor	10.4
39	astrocytoma	10.4
40	cerebellopontine angle tumor	10.4
41	neuroendocrine tumor	10.4
42	vulvar sarcoma	10.4
43	supratentorial primitive neuroectodermal tumors, childhood	10.4
44	trilateral retinoblastoma	10.3
45	ovarian cystic teratoma	10.3
46	pediatric ependymoma	10.3
47	ganglioglioma	10.3
48	penis sarcoma	10.3
49	cauda equina syndrome	10.3
50	cystic teratoma	10.3

Graphical network of the top 20 diseases related to Ewing's Family of Tumors:

Clinical Features for Ewing's Family of Tumors

Drugs & Therapeutics for Ewing's Family of Tumors

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Ewing's Family of Tumors

Drug clinical trials:

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Search NIH Clinical Center for Ewing's Family of Tumors

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Genetic Tests for Ewing's Family of Tumors

Anatomical Context for Ewing's Family of Tumors

Sources:
³²MalaCards
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MalaCards organs/tissues related to Ewing's Family of Tumors:

³²

Bone

Animal Models for Ewing's Family of Tumors or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Ewing's Family of Tumors:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	10.0	LAMB3, EWSR1, LIPI, CDKN2B, CDK4, CDKN1B
2	tumorigenesis	MP:0002006	9.6	ID2, EWSR1, FLI1, CDKN2B, CDK4, CDKN1B
3	renal/urinary system phenotype	MP:0005367	9.6	ID2, PDGFC, EWSR1, DKK1, CDKN2B, CDK4
4	hematopoietic system phenotype	MP:0005397	9.4	ID2, EWSR1, FLI1, DKK2, CDKN2B, CDK4
5	digestive/alimentary phenotype	MP:0005381	9.4	ID2, PDGFC, CDK4, CDKN1B, KIT, LAMB3
6	growth/size phenotype	MP:0005378	9.3	PDGFC, EWSR1, FLI1, LIPI, DKK2, CDK4
7	cellular phenotype	MP:0005384	9.2	ID2, EWSR1, FLI1, DKK2, DKK1, CDKN2B
8	mortality/aging	MP:0010768	8.9	ID2, PDGFC, EWSR1, FLII, FLI1, LIPI

Publications for Ewing's Family of Tumors

Genes related to Ewing's Family of Tumors

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
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Genes related to Ewing's Family of Tumors:

(show all 39)

id	Symbol	Description	Score	Implication
1	EWSR1	EWS RNA-binding protein 1	20.24	GeneCards inferred : Publications, Disorders (show sections)
2	LAMB3	laminin, beta 3	19.73	GeneCards inferred : Publications, Disorders (show sections)
3	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	19.22	GeneCards inferred : Publications, Disorders (show sections)
4	TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	18.71	GeneCards inferred : Publications, Disorders (show sections)
5	DKK2	dickkopf WNT signaling pathway inhibitor 2	18.19	GeneCards inferred : Publications, Disorders (show sections)
6	PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	17.68	GeneCards inferred : Publications, Disorders (show sections)
7	LIPI	lipase, member I	17.17	GeneCards inferred : Publications, Disorders (show sections)
8	PDGFC	platelet derived growth factor C	16.65	GeneCards inferred : Publications, Disorders (show sections)
9	CDK4	cyclin-dependent kinase 4	16.14	GeneCards inferred : Publications, Disorders (show sections)
10	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	15.63	GeneCards inferred : Publications, Disorders (show sections)
11	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	15.12	GeneCards inferred : Publications, Disorders (show sections)
12	TMEM47	transmembrane protein 47	14.60	GeneCards inferred : Publications, Disorders (show sections)
13	LOC284685	EWS RNA-binding protein 1 pseudogene	14.09	GeneCards inferred : Publications, Disorders (show sections)
14	STEAP1	six transmembrane epithelial antigen of the prostate 1	13.58	GeneCards inferred : Publications, Disorders (show sections)
15	ETV7	ets variant 7	13.06	GeneCards inferred : Publications, Disorders (show sections)
16	FLI1	Fli-1 proto-oncogene, ETS transcription factor	12.55	GeneCards inferred : Publications, Disorders (show sections)
17	DKK1	dickkopf WNT signaling pathway inhibitor 1	12.04	GeneCards inferred : Publications, Disorders (show sections)
18	PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	11.53	GeneCards inferred : Publications, Disorders (show sections)
19	ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	11.01	GeneCards inferred : Publications, Disorders (show sections)
20	FLII	flightless I homolog (Drosophila)	10.50	GeneCards inferred : Publications, Disorders (show sections)
21	CASP8	caspase 8, apoptosis-related cysteine peptidase	9.99	GeneCards inferred : Publications, Disorders (show sections)
22	HDAC1	histone deacetylase 1	9.47	GeneCards inferred : Publications, Disorders (show sections)
23	EP300	E1A binding protein p300	8.96	GeneCards inferred : Publications, Disorders (show sections)
24	CASP9	caspase 9, apoptosis-related cysteine peptidase	8.45	GeneCards inferred : Publications, Disorders (show sections)
25	BCL2L1	BCL2-like 1	7.94	GeneCards inferred : Publications, Disorders (show sections)
26	KITLG	KIT ligand	7.42	GeneCards inferred : Publications, Disorders (show sections)
27	RB1	retinoblastoma 1	6.91	GeneCards inferred : Publications, Disorders (show sections)
28	FAS	Fas cell surface death receptor	6.40	GeneCards inferred : Publications, Disorders (show sections)
29	PARP1	poly (ADP-ribose) polymerase 1	5.88	GeneCards inferred : Publications, Disorders (show sections)
30	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	5.37	GeneCards inferred : Publications, Disorders (show sections)
31	CDKN2A	cyclin-dependent kinase inhibitor 2A	4.86	GeneCards inferred : Publications, Disorders (show sections)
32	MTOR	mechanistic target of rapamycin (serine/threonine kinase)	4.35	GeneCards inferred : Publications, Disorders (show sections)
33	CSF3	colony stimulating factor 3 (granulocyte)	3.83	GeneCards inferred : Publications, Disorders (show sections)
34	CASP3	caspase 3, apoptosis-related cysteine peptidase	3.32	GeneCards inferred : Publications, Disorders (show sections)
35	ERBB2	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	2.81	GeneCards inferred : Publications, Disorders (show sections)
36	IGF1R	insulin-like growth factor 1 receptor	2.29	GeneCards inferred : Publications, Disorders (show sections)
37	BCL2	B-cell CLL/lymphoma 2	1.78	GeneCards inferred : Publications, Disorders (show sections)
38	MAPK1	mitogen-activated protein kinase 1	1.27	GeneCards inferred : Publications, Disorders (show sections)
39	TP53	tumor protein p53	0.76	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Ewing's Family of Tumors disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	37	37	37
2	LSBio	-	-	39

Genetic Variations for Ewing's Family of Tumors

Expression for genes affiliated with Ewing's Family of Tumors

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ewing's Family of Tumors

Search GEO for disease gene expression data for Ewing's Family of Tumors.

Pathways for genes affiliated with Ewing's Family of Tumors

Sources:
⁵¹QIAGEN, ⁵³Reactome, ⁴Cell Signaling Technology, ²⁹KEGG, ³⁷NCBI BioSystems Database
See all sources

Pathways related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show all 12)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	GPCR Pathway⁵¹ Hide members Pancreatic Adenocarcinoma⁵¹	10.2	CDK4, CDKN2B
2	Cyclins and Cell Cycle Regulation⁵¹ Hide members G1-S Phase Transition⁵¹ G1 Phase⁵³ Cyclin D associated events in G1⁵³ Cell Cycle Control by BTG Proteins⁵¹	10.1	CDKN1B, CDK4, CDKN2B
3	Glioblastoma Multiforme⁵¹	10.1	PDGFC, CDKN1B, CDK4
4	Wnt / Hedgehog / Notch⁴	10.0	ID2, DKK2, DKK1
5	Small cell lung cancer²⁹	10.0	CDKN1B, CDK4, LAMB3, CDKN2B
6	Glioma²⁹ Hide members Prostate cancer²⁹ Signaling Pathways in Glioblastoma³⁷ Melanoma²⁹ Non-small cell lung cancer²⁹ Bladder cancer²⁹	10.0	CDKN2B, CDKN1B, CDK4, PDGFC
7	Mitotic G1-G1/S phases⁵³ Hide members G1 to S cell cycle control³⁷ G1/S Transition⁵³	9.9	CDKN1B, CDKN2B, PSMD9, CDK4
8	Validated targets of C-MYC transcriptional repression³⁷	9.9	CDKN1B, DKK1, ID2, CDKN2B
9	Pathways in cancer²⁹	9.9	LAMB3, KIT, CDKN1B, CDK4, CDKN2B
10	PI3K-Akt signaling pathway²⁹	9.9	CDK4, CDKN1B, KIT, LAMB3, PDGFC
11	Transcriptional misregulation in cancer²⁹	9.7	CDKN1B, ID2, EWSR1, FLI1, ETV7
12	Rho Family GTPases⁵¹ Hide members ILK Signaling⁵¹ Molecular Mechanisms of Cancer⁵¹ ERK Signaling⁵¹ MAPK Signaling⁵¹	9.6	PDGFC, KIT, TNFRSF10A, CDKN2B, CDK4, CDKN1B

Compounds for genes affiliated with Ewing's Family of Tumors

Sources:
⁴⁴Novoseek, ⁴⁹PharmGKB, ¹¹DrugBank, ²⁴HMDB
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Compounds related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show all 14)

id	Compound	Score	Top Affiliating Genes
1	butyrate⁴⁴	10.5	ID2
2	trastuzumab⁴⁴ ⁴⁹ ¹¹	12.3	KIT, CDKN1B, CDK4
3	gefitinib⁴⁴ ⁴⁹ ¹¹	12.3	CDK4, CDKN1B, KIT
4	paclitaxel⁴⁴ ⁴⁹ ¹¹	12.3	CDKN1B, CDK4, TNFRSF10A
5	flavopiridol⁴⁴ ¹¹	11.2	TNFRSF10A, CDK4, CDKN1B, KIT
6	5fluorouracil⁴⁴	10.2	TNFRSF10A, CDK4, CDKN1B, KIT
7	p003⁴⁴	10.2	KIT, CDKN1B, CDKN2B
8	cytarabine⁴⁴ ⁴⁹ ¹¹	12.1	CDKN2B, CDKN1B, KIT
9	rapamycin⁴⁴	10.0	ETV7, CDK4, CDKN1B, KIT
10	glycogen⁴⁴ ²⁴	10.9	KIT, CDKN1B, CDK4, DKK1
11	pd 98,059⁴⁴	9.9	KIT, CDKN1B, CDK4, CDKN2B
12	oligonucleotide⁴⁴	9.8	ID2, TNFRSF10A, EWSR1, FLI1, CDK4, CDKN1B
13	retinoic acid⁴⁴ ²⁴	10.7	KIT, ID2, TNFRSF10A, EWSR1, ETV7, CDKN2B
14	doxorubicin⁴⁴ ⁴⁹ ¹¹	11.7	TNFRSF10A, CDK4, CDKN1B, KIT

GO Terms for genes affiliated with Ewing's Family of Tumors

Sources:
¹⁶Gene Ontology
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Cellular components related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	8.8	KIT, PDGFC, EWSR1, PSMD9, FLII, FLI1

Biological processes related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of phosphorylation	GO:042326	10.2	CDKN1B, CDKN2B
2	megakaryocyte development	GO:035855	10.2	KIT, FLI1
3	organ morphogenesis	GO:009887	9.9	ETV7, FLI1, PDGFC
4	cellular response to lithium ion	GO:071285	9.9	CDKN1B, ID2

Molecular functions related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO:004861	10.2	CDKN1B, CDKN2B
2	protein binding	GO:005515	8.4	LAMB3, ID2, TNFRSF10A, EWSR1, PSMD9, FLII