MCID: EWN002
MIFTS: 32

Ewing's Family of Tumors malady

Neuronal, Bone, Cancer, Genetic categories

Summaries for Ewing's Family of Tumors

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33MalaCards
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MalaCards: Ewing's Family of Tumors, also known as extraosseous ewings sarcoma-primitive neuroepithelial tumor, is related to cerebral primitive neuroectodermal tumor and neuroepithelioma. An important gene associated with Ewing's Family of Tumors is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are GPCR Pathway and Cyclins and Cell Cycle Regulation. The compounds butyrate and trastuzumab have been mentioned in the context of this disorder. Related mouse phenotypes are integument and tumorigenesis.

Aliases & Classifications for Ewing's Family of Tumors

Sources:
61UMLS, 43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer, Genetic
Anatomical: Neuronal, Bone


Aliases & Descriptions:

ewing's family of tumors 43
extraosseous ewings sarcoma-primitive neuroepithelial tumor 61
primitive neuroectodermal tumor 43
ewing’s tumor of bone 43
extraosseous ewing’s 43
ewing family of tumors 43
askin’s tumor 43


Related Diseases for Ewing's Family of Tumors

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Ewing's Family of Tumors family:

ewing's family localized tumor

Diseases related to Ewing's Family of Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral primitive neuroectodermal tumor31.3FLI1, EWSR1
2neuroepithelioma31.0EWSR1, FLI1
3synovial sarcoma30.5FLI1, EWSR1
4gastrointestinal stromal tumor30.5KIT
5germ cell tumors30.5KIT
6acute leukemia30.5TNFRSF10A, EWSR1, CDKN2B, KIT
7angiosarcoma30.3FLI1
8clear cell sarcoma30.3KIT, EWSR1
9wilms tumor30.3FLI1, EWSR1
10acute lymphoblastic leukemia, childhood30.3CDKN1B, CDK4, CDKN2B
11bladder carcinoma30.3CDKN1B, CDK4, CDKN2B, TNFRSF10A
12squamous cell carcinoma30.3TNFRSF10A, PSMD9, PKP1, ETV7, CDKN2B, CDK4
13supratentorial primitive neuroectodermal tumor11.1
14extraosseous ewings sarcoma-primitive neuroepithelial tumor10.8
15intracranial primitive neuroectodermal tumor10.8
16rhabdoid tumor10.7
17bone ewing's sarcoma10.7
18n syndrome10.7
19teratoma10.6
20atypical teratoid rhabdoid tumor10.6
21childhood medulloblastoma10.6
22embryonal tumor with multilayered rosettes10.6
23extraskeletal ewing sarcoma10.6
24soft tissue sarcoma10.6
25supratentorial primitive neuroectodermal tumors, childhood10.6
26cerebellopontine angle primitive neuroectodermal10.5
27unilateral retinoblastoma10.5
28localized peripheral primitive neuroectodermal tumor10.5
29astrocytoma10.5
30vagina sarcoma10.5
31vulvar sarcoma10.5
32ependymoma10.5
33olfactory neuroblastoma10.4
34trilateral retinoblastoma10.4
35ovarian cystic teratoma10.4
36pediatric ependymoma10.4
37ganglioglioma10.4
38penis sarcoma10.4
39cauda equina syndrome10.4
40brain medulloblastoma10.4
41pineoblastoma, childhood10.4
42desmoplastic small round cell tumor10.4
43heart tumor10.4
44nonseminomatous germ cell tumor10.4
45moyamoya disease10.2
46neurofibromatosis10.2
47duodenal ulcer10.2
48myelitis10.2
49familial retinoblastoma10.2
50epidermolysis bullosa simplex10.2

Graphical network of the top 20 diseases related to Ewing's Family of Tumors:



Diseases related to ewing's family of tumors

Clinical Features for Ewing's Family of Tumors

Drugs & Therapeutics for Ewing's Family of Tumors

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Ewing's Family of Tumors

Anatomical Context for Ewing's Family of Tumors

Animal Models for Ewing's Family of Tumors or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Ewing's Family of Tumors

Sources:
51PubMed
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Articles related to Ewing's Family of Tumors:

idTitleAuthorsYear
1
Epithelial cell adhesion molecules and epithelial mesenchymal transition (EMT) markers in Ewing's sarcoma family of tumors (ESFTs). Do they offer any prognostic significance? (22898789)
2012

Genetic Variations for Ewing's Family of Tumors

Expression for genes affiliated with Ewing's Family of Tumors

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ewing's Family of Tumors

Search GEO for disease gene expression data for Ewing's Family of Tumors.

Pathways for genes affiliated with Ewing's Family of Tumors

Sources:
52QIAGEN, 54Reactome, 4Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database
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Compounds for genes affiliated with Ewing's Family of Tumors

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1butyrate4510.5ID2
2trastuzumab45 50 1112.3CDK4, KIT, CDKN1B
3gefitinib45 50 1112.3CDK4, CDKN1B, KIT
4paclitaxel45 50 1112.3TNFRSF10A, CDKN1B, CDK4
5flavopiridol45 1111.2TNFRSF10A, KIT, CDKN1B, CDK4
65fluorouracil4510.2TNFRSF10A, CDK4, CDKN1B, KIT
7p0034510.2KIT, CDKN1B, CDKN2B
8cytarabine45 50 1112.1CDKN2B, CDKN1B, KIT
9rapamycin4510.0ETV7, CDK4, CDKN1B, KIT
10glycogen45 2410.9DKK1, CDK4, CDKN1B, KIT
11pd 98,059459.9KIT, CDK4, CDKN1B, CDKN2B
12oligonucleotide459.8ID2, TNFRSF10A, EWSR1, FLI1, CDK4, CDKN1B
13retinoic acid45 2410.7KIT, ID2, TNFRSF10A, EWSR1, ETV7, CDKN2B
14doxorubicin45 50 1111.7KIT, CDK4, CDKN1B, TNFRSF10A

GO Terms for genes affiliated with Ewing's Family of Tumors

Sources:
16Gene Ontology
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Cellular components related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.8KIT, PDGFC, EWSR1, PSMD9, FLII, FLI1

Biological processes related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of phosphorylationGO:04232610.2CDKN1B, CDKN2B
2megakaryocyte developmentGO:03585510.2KIT, FLI1
3organ morphogenesisGO:0098879.9ETV7, FLI1, PDGFC
4cellular response to lithium ionGO:0712859.9CDKN1B, ID2

Molecular functions related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN2B, CDKN1B
2protein bindingGO:0055158.4ID2, TNFRSF10A, EWSR1, PSMD9, FLII, PKP1

Products for genes affiliated with Ewing's Family of Tumors

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Ewing's Family of Tumors

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet