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MCID: EWN002

Ewing's Family of Tumors malady
20 genes, 1 tissue, 79 related diseases, clinical trials.

Summaries for Ewing's Family of Tumors

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MalaCards: Ewing's Family of Tumors, also known as primitive neuroectodermal tumor, is related to sarcoma and peripheral primitive neuroectodermal tumor. An important gene associated with Ewing's Family of Tumors is EWSR1 (Ewing sarcoma breakpoint region 1), and among its related pathways are Cell cycle Regulation of G1/S transition (part 1) and Cyclins and Cell Cycle Regulation. The compounds indole-3-carbinol and flavopiridol have been mentioned in the context of this disorder. Affiliated tissues include endothelial and endothelial, and related mouse phenotypes are tumorigenesis and integument.

Aliases & Classifications for Ewing's Family of Tumors

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39NIH Rare Diseases
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ewing's family of tumors 39
primitive neuroectodermal tumor 39
ewing’s tumor of bone 39
extraosseous ewing’s 39
ewing family of tumors 39
askin’s tumor 39



Related Diseases for Ewing's Family of Tumors

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16GeneCards, 17GeneDecks
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Diseases related to ewing's family of tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma37.6CDK4, CASP9, EWSR1, FLI1
2peripheral primitive neuroectodermal tumor37.5FLI1, FLII, EWSR1
3medulloblastoma36.3DKK1, CASP9, CDK4, CDKN2B
4cerebral primitive neuroectodermal tumor35.7EWSR1, FLI1
5neuroepithelioma31.4EWSR1, FLI1
6synovial sarcoma31.2EWSR1, FLI1
7malignant glioma30.2CDKN2B, CDK4, CASP9, TNFRSF10A, CDKN1B
8melanoma29.7TNFRSF10A, FLI1, EWSR1, CASP9, CDK4, CDKN2B
9multiple myeloma13.7DKK1
10malignant thyroid stimulating hormone producing neoplasm of pituitary gland13.5CDKN1B, TNFRSF10A
11primitive neuroectodermal tumor13.5
12liposarcoma13.5FLI1, EWSR1, CDK4
13acute leukemia13.5TNFRSF10A, EWSR1, CDKN2B
14prostate cancer13.5CDKN1B, CDK4
15hepatoblastoma13.4DKK1
16myxoid liposarcoma of the ovary13.4CDK4, EWSR1
17rhabdomyosarcoma13.4FLI1, EWSR1, CDK4
18cholangiocarcinoma13.4CASP9, CDKN1B
19lung cancer13.4CDK4
20malignant mesothelioma13.4CDKN2B, CDK4
21oral cancer13.3CDKN1B, CDK4, CASP9
22acute lymphoblastic leukemia, childhood13.3CDKN1B, CDKN2B, CDK4
23endometrial carcinoma13.2ETV7, CASP9, CDK4, CDKN1B
24myeloma13.2CDKN2B, CASP9, TNFRSF10A, DKK1
25pancreatic cancer13.2DKK1, TNFRSF10A, CDK4, CDKN1B
26adenocarcinoma13.2TNFRSF10A, FLI1, ID2, CDK4, CDKN1B
27squamous cell carcinoma of the head and neck13.1PKP1, TNFRSF10A, CASP9, CDK4, CDKN2B
28non-hodgkin lymphoma13.1TNFRSF10A, FLI1, CDKN2B, CDKN1B
29hepatocellular carcinoma13.1DKK1, TNFRSF10A, CDK4, CDKN2B, CDKN1B
30osteosarcoma13.1DKK1, TNFRSF10A, ID2, CASP9, CDK4
31b-cell lymphomas13.1CASP9, CDK4, CDKN2B, CDKN1B
32myeloid leukemia13.1TNFRSF10A, ETV7, CASP9, CDK4, CDKN2B
33ovarian cancer13.1TNFRSF10A, ETV7, CASP9, CDK4, CDKN1B
34bladder carcinoma13.1TNFRSF10A, CASP9, CDK4, CDKN2B, CDKN1B
35breast cancer13.0ETV7, CASP9, CDK4, CDKN1B
36retinoblastoma12.9ETV7, ID2, CASP9, CDK4, CDKN2B, CDKN1B
37non-small cell lung carcinoma12.9TNFRSF10A, CASP9, CDK4, CDKN2B, CDKN1B
38cervical cancer12.9CDKN1B, CASP9, TNFRSF10A
39gastric cancer12.9CDKN1B, CDKN2B, CASP9, TNFRSF10A
40burkitt's lymphoma12.8TNFRSF10A, FLI1, ID2, CASP9, CDK4, CDKN2B
41glioblastoma12.8PSMD9, TNFRSF10A, CASP9, CDK4, CDKN2B, CDKN1B
42squamous cell carcinoma12.7PSMD9, PKP1, TNFRSF10A, ETV7, CASP9, CDK4
43leukemia12.6TNFRSF10A, FLI1, ETV7, EWSR1, ID2, CASP9
44colon cancer12.2DKK1, TNFRSF10A, CASP9, CDK4, CDKN2B, CDKN1B
45supratentorial primitive neuroectodermal tumor11.1
46cerebritis9.6
47supratentorial primitive neuroectodermal tumors, childhood9.3
48intracranial primitive neuroectodermal tumor9.0
49localized peripheral primitive neuroectodermal tumor8.7
50rhabdoid tumor8.7

Graphical network of the top 20 diseases related to ewing's family of tumors:



Diseases related to ewing's family of tumors

Symptoms for Ewing's Family of Tumors

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Drugs & Therapeutics for Ewing's Family of Tumors

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5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Ewing's Family of Tumors

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Anatomical Context for Ewing's Family of Tumors

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29MalaCards
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MalaCards organs/tissues related to ewing's family of tumors:

29
Endothelial

Animal Models for Ewing's Family of Tumors or affiliated genes

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33MGI, 26inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to ewing's family of tumors:

33
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
tumorigenesis
MP:00020069.7CDKN1B, CDKN2B, CDK4, ID2, EWSR1, FLI1
2
integument phenotype
MP:00107719.4LIPI, EWSR1, PDGFC, ID2, CDK4, CDKN2B
3
renal/urinary system phenotype
MP:00053679.2DKK1, EWSR1, PDGFC, ID2, CDK4, CDKN2B
4
mortality/aging
MP:00107688.8LAMB3, DKK1, LIPI, FLI1, FLII, EWSR1

Publications for Ewing's Family of Tumors

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47PubMed
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Articles related to ewing's family of tumors:

(show all 30)
idTitleAuthorsYearAffiliating Genes
1Impairment of p53 acetylation by EWS-Fli1 chimeric pro tein in Ewing family tumors. (22266186)Li Y.... Zhu Y.2012TP53, HDAC1, EP300
2Phase II study of ganitumab, a fully human anti-type-1 insulin-like growth factor receptor antibody, in patients with metastatic Ewing family tumors or desmoplastic small round cell tumors. (22508822)Tap W.D.... Tolcher A.2012IGF1R
3Inhibition of the transcriptional function of p53 by EWS-Fli1 chimeric protein in Ewing Family Tumors. (20153576)Li Y.... Iwamoto Y.2010LOC284685
4EWS/ETS regulates the expression of the Dickkopf family in Ewing family tumor cells. (19247449)Miyagawa Y.... Kiyokawa N.2009DKK1, DKK2, EWSR1
5Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in Ewing family of tumors. (19429803)Zenali M.J.... Brown R.E.2009MAPK1, MTOR
6Primary extraskeletal Ewing family tumor with complex epithelial differentiation: a unique case arising in the lateral neck presenting with Horner syndrome. (18769338)Weinreb I.... Perez-OrdoA+ez B.2008FLI1
7Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors. (18838963)Potikyan G.... Denny C.T.2008EWSR1, ETV7
8Inducible expression of chimeric EWS/ETS proteins confers Ewing's family tumor-like phenotypes to human mesenchymal progenitor cells. (18212050)Miyagawa Y.... Kiyokawa N.2008EWSR1
9The mechanism of cross-resistance to proteasome inhib itor bortezomib and overcoming resistance in Ewing's family tumor cells. (17786311)Nakamura T.... Iwamoto Y.2007TNFRSF10A
10Immunophenotypic profile of biomarkers related to anti-apoptotic and neural development pathways in the Ewing's family of tumors (EFT) and their therapeutic implications. (17695539)Navarro S.... Llombart-Bosch A.2007ERBB2, FAS, KITLG
11Novel markers of subclinical disease for Ewing family tumors from gene expression profiling. (18056173)Cheung I.Y.... Cheung N.K.2007PKP1, STEAP1, TMEM47
12Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. (17520676)Li Y.... Iwamoto Y.2007BCL2, CASP3, ABCC1
13The possible role of EWS-Fli1 in evasion of senescence in Ewing family tumors. (16424012)Matsunobu T.... Iwamoto Y.2006PSMD9
14Antitumor effects of histone deacetylase inhibitor on Ewing's family tumors. (15849726)Sakimura R.... Iwamoto Y.2005RB1
15Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases. (16006796)Folpe A.L.... Weiss S.W.2005FLI1
16Aberrant laminin beta3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors. (15846078)Irifune H.... Tokino T.2005LAMB3, ETV7
17The prognostic and therapeutic relevance of p27kip1 in Ewing's family tumors. (14871979)Matsunobu T.... Iwamoto Y.2004CDKN1B
18DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets. (15548687)Staege M.S.... Burdach S.E.2004LIPI
19Expression of c-kit in Ewing family of tumors: a comparison of different immunohistochemical protocols. (15383930)Ahmed A.... Lacson A.2004KIT
20Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines. (12032822)Zwerner J.P.... May W.A.2002PDGFC
21The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors. (12447693)Nishimori H.... Tokino T.2002ID2
22Biology of EWS/ETS fusions in Ewing's family tumors. (11607824)Arvand A.... Denny C.T.2001EWSR1, ETV7
23PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors. (11313995)Zwerner J.P.... May W.A.2001PDGFC, FLII, ETV7
24A method for accurate detection of translocation junctions in Ewing family of tumors. (11471459)Morishita T.... Sarkar G.2001EWSR1
25Chemotherapy dose-intensification for pediatric patie nts with Ewing's family of tumors and desmoplastic small round-cell tumors: a f easibility study at St. Jude Children's Research Hospital. (10458232)Marina N.M.... Meyer W.H.1999CSF3
26Ewing family tumors: potential prognostic value of reverse-transcriptase polymerase chain reaction detection of minimal residual disease in peripheral blood samples. (9836070)de Alava E.... Pardo-MindA!n F.J.1998EWSR1
27Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors. (9393981)Kovar H.... Gadner H.1997CDK4, CDKN2A, CDKN2B
28The Ewing family of tumors. Ewing's sarcoma and primitive neuroectodermal tumors. (9286296)Grier H.E.1997FLI1, EWSR1
29The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains. (8084618)Ohno T.... Reddy E.S.P.1994EWSR1
30The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts. (8022439)Delattre O.... Triche T.J.1994FLI1, EWSR1

Variations for Ewing's Family of Tumors

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Expression for genes affiliated with Ewing's Family of Tumors

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Ewing's Family of Tumors

Pathways for genes affiliated with Ewing's Family of Tumors

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12EMD Millipore, 48QIAGEN, 50Reactome, 27KEGG, 34NCBI BioSystems Database
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Pathways related to ewing's family of tumors according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Cell cycle Regulation of G1/S transition (part 1)12
10.1CDK4, CDKN2B, CDKN1B
2
Cyclins and Cell Cycle Regulation48
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10.1CDK4, CDKN2B, CDKN1B
3
Glioblastoma Multiforme48
10.1CDKN1B, CDK4, PDGFC
4
Chronic myeloid leukemia27
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10.1CDKN1B, CDK4, CASP9
5
Glioma27
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10.0PDGFC, CASP9, CDK4, CDKN2B
6
Measles27
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10.0CDKN1B, CDK4, CASP9, TNFRSF10A
7
Integrated Pancreatic Cancer Pathway34
10.0CDKN1B, CDKN2B, CDK4, CASP9
8
G1/S Transition50
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9.9CDKN1B, CDKN2B, CDK4, PSMD9
9
Validated targets of C-MYC transcriptional repression34
9.9DKK1, ID2, CDKN2B, CDKN1B
10
Pathways in cancer27
9.9CASP9, CDK4, CDKN2B, CDKN1B, LAMB3
11
Small cell lung cancer27
9.9LAMB3, CDKN1B, CDKN2B, CDK4, CASP9
12
Rho Family GTPases48
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9.6TNFRSF10A, PDGFC, CASP9, CDK4, CDKN2B, CDKN1B
13
Cell Cycle50
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9.6PSMD9, CDK4, CDK4, CDKN2B, CDKN2B, CDKN1B

Compounds for genes affiliated with Ewing's Family of Tumors

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41Novoseek, 11DrugBank, 55Tocris Bioscience, 46PharmGKB, 22HMDB
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Compounds related to ewing's family of tumors according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1indole-3-carbinol4110.3CASP9, CDK4, CDKN1B
2flavopiridol41 1111.2CDKN1B, CDK4, CASP9, TNFRSF10A
3bortezomib41 1111.2CDKN1B, CASP9, TNFRSF10A
4luteolin41 5511.2CDK4, CASP9
5camptothecin41 55 1112.2TNFRSF10A, CASP9, CDK4, CDKN1B
6gemcitabine41 46 1112.2TNFRSF10A, CASP9, CDKN1B
7egcg4110.1CDKN1B, CDK4, CASP9, PSMD9
8lactacystin4110.1CDKN1B, CDK4, CASP9
9butyrate4110.0TNFRSF10A, ID2, CASP9, CDK4, CDKN1B
10lovastatin41 46 55 1113.0CDKN1B, CDK4, CASP9
11oligonucleotide419.8TNFRSF10A, FLI1, EWSR1, ID2, CDK4, CDKN1B
12retinoic acid41 55 2211.7TNFRSF10A, ETV7, EWSR1, ID2, CASP9, CDK4
13paclitaxel41 46 1111.7TNFRSF10A, CASP9, CDK4, CDKN1B

GO Terms for genes affiliated with Ewing's Family of Tumors

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15Gene Ontology
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Cellular components related to ewing's family of tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.8CDKN1B, PKP1, FLI1, FLII, ETV7, EWSR1

Biological processes related to ewing's family of tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to lithium ionGO:07128510.2CDKN1B, ID2
2G1 phase of mitotic cell cycleGO:00008010.0CDKN1B, CDKN2B, CDK4
3organ morphogenesisGO:0098879.7PDGFC, ETV7, FLI1

Molecular functions related to ewing's family of tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase inhibitor activityGO:00486110.2CDKN1B, CDKN2B
2protein bindingGO:0055158.4LAMB3, DKK1, PSMD9, PKP1, TNFRSF10A, FLII

Products for genes affiliated with Ewing's Family of Tumors

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  • Antibodies
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Sources for Ewing's Family of Tumors

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3CDC
13ExPASy
14FMA
21HGMD
22HMDB
23ICD10
24ICD10 via Orphanet
25ICD9CM
27KEGG
31MeSH
32MESH via Orphanet
33MGI
36NCIt
37NDF-RT
40NINDS
41Novoseek
43OMIM
44OMIM via Orphanet
47PubMed
48QIAGEN
53SNOMED-CT via Orphanet
56UMLS
57UMLS via Orphanet
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