MCID: EWN002
MIFTS: 36

Ewing's Family of Tumors malady

Neuronal diseases, Bone diseases, Cancer diseases, Genetic diseases categories

Summaries for Ewing's Family of Tumors

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MalaCards: Ewing's Family of Tumors, also known as extraosseous ewings sarcoma-primitive neuroepithelial tumor, is related to medulloblastoma and cerebral primitive neuroectodermal tumor. An important gene associated with Ewing's Family of Tumors is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are GPCR Pathway and Cyclins and Cell Cycle Regulation. The compounds butyrate and trastuzumab have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are integument and tumorigenesis.

Aliases & Classifications for Ewing's Family of Tumors

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Neuronal diseases, Bone diseases


Aliases & Descriptions:

ewing's family of tumors 42
extraosseous ewings sarcoma-primitive neuroepithelial tumor 60
primitive neuroectodermal tumor 42
ewing’s tumor of bone 42
extraosseous ewing’s 42
ewing family of tumors 42
askin’s tumor 42


Related Diseases for Ewing's Family of Tumors

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17GeneCards, 18GeneDecks
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Diseases in the Ewing's Family of Tumors family:

Ewing's Family Localized Tumor

Diseases related to Ewing's Family of Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1medulloblastoma31.4CDK4, CDKN2B, DKK1
2cerebral primitive neuroectodermal tumor31.2FLI1, EWSR1
3retinoblastoma30.8ID2, ETV7, CDKN2B, CDK4, CDKN1B
4rhabdomyosarcoma30.6CDK4, FLI1, EWSR1
5embryonal rhabdomyosarcoma30.6CDK4, EWSR1
6leukemia30.6ID2, TNFRSF10A, EWSR1, FLI1, ETV7, CDKN2B
7synovial sarcoma30.5FLI1, EWSR1
8gastrointestinal stromal tumor30.5KIT
9endometrial carcinoma30.5ETV7, CDK4, CDKN1B
10acute leukemia30.5TNFRSF10A, EWSR1, CDKN2B, KIT
11angiosarcoma30.2FLI1
12clear cell sarcoma30.2KIT, EWSR1
13osteosarcoma30.2ID2, TNFRSF10A, DKK1, CDK4
14malignant glioma30.2TNFRSF10A, CDKN2B, CDK4, CDKN1B
15myeloid leukemia30.2KIT, CDK4, CDKN2B, ETV7, TNFRSF10A
16bladder carcinoma30.2CDKN1B, CDK4, CDKN2B, TNFRSF10A
17squamous cell carcinoma30.2TNFRSF10A, PSMD9, PKP1, ETV7, CDKN2B, CDK4
18peripheral primitive neuroectodermal tumor30.2EWSR1, FLII, FLI1
19sarcoma30.2KIT, CDK4, FLI1, EWSR1
20melanoma30.2TNFRSF10A, EWSR1, FLI1, CDKN2B, CDK4, CDKN1B
21supratentorial primitive neuroectodermal tumor11.1
22cerebritis10.8
23extraosseous ewings sarcoma-primitive neuroepithelial tumor10.8
24intracranial primitive neuroectodermal tumor10.8
25kidney sarcoma10.7
26atypical teratoid rhabdoid tumor10.6
27childhood medulloblastoma10.6
28bone ewing's sarcoma10.6
29extracranial arteriovenous malformation10.5
30cervicitis10.5
31cerebellopontine angle primitive neuroectodermal10.5
32neuronitis10.5
33extraosseous ewing's sarcoma10.5
34pineoblastoma10.5
35prostatitis10.5
36thyroiditis10.5
37unilateral retinoblastoma10.4
38localized peripheral primitive neuroectodermal tumor10.4
39astrocytoma10.4
40cerebellopontine angle tumor10.4
41neuroendocrine tumor10.4
42vulvar sarcoma10.4
43supratentorial primitive neuroectodermal tumors, childhood10.4
44trilateral retinoblastoma10.3
45ovarian cystic teratoma10.3
46pediatric ependymoma10.3
47ganglioglioma10.3
48penis sarcoma10.3
49cauda equina syndrome10.3
50cystic teratoma10.3

Graphical network of the top 20 diseases related to Ewing's Family of Tumors:



Diseases related to ewing's family of tumors

Clinical Features for Ewing's Family of Tumors

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Drugs & Therapeutics for Ewing's Family of Tumors

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Ewing's Family of Tumors

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Anatomical Context for Ewing's Family of Tumors

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32MalaCards
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MalaCards organs/tissues related to Ewing's Family of Tumors:

32
Bone

Animal Models for Ewing's Family of Tumors or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Ewing's Family of Tumors:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.0LAMB3, EWSR1, LIPI, CDKN2B, CDK4, CDKN1B
2MP:00020069.6ID2, EWSR1, FLI1, CDKN2B, CDK4, CDKN1B
3MP:00053679.6ID2, PDGFC, EWSR1, DKK1, CDKN2B, CDK4
4MP:00053979.4ID2, EWSR1, FLI1, DKK2, CDKN2B, CDK4
5MP:00053819.4ID2, PDGFC, CDK4, CDKN1B, KIT, LAMB3
6MP:00053789.3PDGFC, EWSR1, FLI1, LIPI, DKK2, CDK4
7MP:00053849.2ID2, EWSR1, FLI1, DKK2, DKK1, CDKN2B
8MP:00107688.9ID2, PDGFC, EWSR1, FLII, FLI1, LIPI

Publications for Ewing's Family of Tumors

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Genetic Variations for Ewing's Family of Tumors

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Expression for genes affiliated with Ewing's Family of Tumors

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ewing's Family of Tumors

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Pathways for genes affiliated with Ewing's Family of Tumors

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51QIAGEN, 53Reactome, 4Cell Signaling Technology, 29KEGG, 37NCBI BioSystems Database
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Compounds for genes affiliated with Ewing's Family of Tumors

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1butyrate4410.5ID2
2trastuzumab44 49 1112.3KIT, CDKN1B, CDK4
3gefitinib44 49 1112.3CDK4, CDKN1B, KIT
4paclitaxel44 49 1112.3CDKN1B, CDK4, TNFRSF10A
5flavopiridol44 1111.2TNFRSF10A, CDK4, CDKN1B, KIT
65fluorouracil4410.2TNFRSF10A, CDK4, CDKN1B, KIT
7p0034410.2KIT, CDKN1B, CDKN2B
8cytarabine44 49 1112.1CDKN2B, CDKN1B, KIT
9rapamycin4410.0ETV7, CDK4, CDKN1B, KIT
10glycogen44 2410.9KIT, CDKN1B, CDK4, DKK1
11pd 98,059449.9KIT, CDKN1B, CDK4, CDKN2B
12oligonucleotide449.8ID2, TNFRSF10A, EWSR1, FLI1, CDK4, CDKN1B
13retinoic acid44 2410.7KIT, ID2, TNFRSF10A, EWSR1, ETV7, CDKN2B
14doxorubicin44 49 1111.7TNFRSF10A, CDK4, CDKN1B, KIT

GO Terms for genes affiliated with Ewing's Family of Tumors

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16Gene Ontology
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Cellular components related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.8KIT, PDGFC, EWSR1, PSMD9, FLII, FLI1

Biological processes related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of phosphorylationGO:04232610.2CDKN1B, CDKN2B
2megakaryocyte developmentGO:03585510.2KIT, FLI1
3organ morphogenesisGO:0098879.9ETV7, FLI1, PDGFC
4cellular response to lithium ionGO:0712859.9CDKN1B, ID2

Molecular functions related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00486110.2CDKN1B, CDKN2B
2protein bindingGO:0055158.4LAMB3, ID2, TNFRSF10A, EWSR1, PSMD9, FLII

Products for genes affiliated with Ewing's Family of Tumors

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Sources for Ewing's Family of Tumors

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet