MCID: EWN002
MIFTS: 46

Ewing's Family of Tumors malady

Genetic diseases, Rare diseases, Neuronal diseases, Bone diseases, Cancer diseases categories

Aliases & Classifications for Ewing's Family of Tumors

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Aliases & Descriptions for Ewing's Family of Tumors:

Name: Ewing's Family of Tumors 42
Primitive Neuroectodermal Tumor 42 10
Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor 61
Ewing Sarcoma/peripheral Primitive Neuroectodermal Tumor 61
Neuroectodermal Tumor, Primitive 61
Ewing’s Tumor of Bone 42
 
Extraosseous Ewing’s 42
Ewing Family of Tumors 42
Neuroectodermal Tumors 61
Askin’s Tumor 42
Ewings Sarcoma 61


Classifications:



Summaries for Ewing's Family of Tumors

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MalaCards based summary: Ewing's Family of Tumors, also known as primitive neuroectodermal tumor, is related to medulloblastoma and rhabdomyosarcoma. An important gene associated with Ewing's Family of Tumors is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and E2F mediated regulation of DNA replication. The drugs cyclophosphamide and etoposide and the compounds ag-1296 and flavopiridol have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Related Diseases for Ewing's Family of Tumors

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Diseases related to Ewing's Family of Tumors via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1medulloblastoma31.6ERBB2, CDK4, CDKN2B
2rhabdomyosarcoma31.1FLI1, EWSR1, CDK4
3neuroectodermal tumor31.1EWSR1, FLI1
4embryonal rhabdomyosarcoma31.1EWSR1, CDK4
5peripheral primitive neuroectodermal tumor30.9FLI1, EWSR1
6lymphoblastic lymphoma30.9CDKN2B, FLI1
7neurofibroma30.8KITLG, KIT
8gastrointestinal stromal tumor30.8KITLG, KIT
9astrocytoma30.6MAPK1, CDK4, CDKN2A, CDKN2B
10ewing sarcoma30.6KITLG, MAPK1, EWSR1
11retinoblastoma30.1CDKN2A, ERBB2, CDK4, CDKN2B, MAPK1, MTOR
12sarcoma30.0EWSR1, FLI1, MTOR, CDK4, KITLG, KIT
13myelodysplastic syndrome30.0CSF3, KITLG, FAS, CDKN2B, KIT
14breast cancer29.9CDK4, MAPK1, FAS, ERBB2, MTOR
15malignant glioma29.7CDK4, CDKN2A, MAPK1, MTOR, FAS, CDKN2B
16myeloid leukemia29.4CSF3, CDKN2B, CDK4, KITLG, KIT, FAS
17glioblastoma29.3MAPK1, MTOR, KIT, ERBB2, CDKN2A, CDK4
18leukemia28.9CSF3, KITLG, CDK4, CDKN2B, CDKN2A, KIT
19melanoma28.9FAS, CDK4, EWSR1, KITLG, KIT, MAPK1
20supratentorial primitive neuroectodermal tumor11.1
21extraosseous ewing's sarcoma11.1
22askin's tumor10.9
23cerebral primitive neuroectodermal tumor10.9
24cerebritis10.9
25rhabdoid tumor10.8
26teratoma10.7
27atypical teratoid rhabdoid tumor10.6
28intracranial primitive neuroectodermal tumor10.6
29cervicitis10.6
30pineoblastoma10.6
31prostatitis10.6
32neuronitis10.6
33childhood medulloblastoma10.6
34thyroiditis10.6
35supratentorial primitive neuroectodermal tumors, childhood10.6
36adult acute lymphocytic leukemia10.5CDKN2B
37insulin-like growth factor i10.5
38cystic teratoma10.5
39ependymoma10.5
40connective tissue benign neoplasm10.4FLI1, EWSR1
41ganglioglioma10.4
42cauda equina syndrome10.4
43unilateral retinoblastoma10.4
44bone ewing's sarcoma10.4
45mediastinitis10.4
46paraplegia10.4
47nonseminomatous germ cell tumor10.4
48pineoblastoma, childhood10.4
49extraskeletal ewing sarcoma10.4
50myoepithelioma10.4EWSR1, KITLG

Graphical network of the top 20 diseases related to Ewing's Family of Tumors:



Diseases related to ewing's family of tumors

Symptoms for Ewing's Family of Tumors

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Drugs & Therapeutics for Ewing's Family of Tumors

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Drug clinical trials:

Search ClinicalTrials for Ewing's Family of Tumors

Search NIH Clinical Center for Ewing's Family of Tumors

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Ewing's Family of Tumors

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Anatomical Context for Ewing's Family of Tumors

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MalaCards organs/tissues related to Ewing's Family of Tumors:

31
Bone

Animal Models for Ewing's Family of Tumors or affiliated genes

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MGI Mouse Phenotypes related to Ewing's Family of Tumors:

35 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9CDKN2A, KITLG, KIT, FAS
2MP:00053718.9ERBB2, KIT, FAS, KITLG
3MP:00053918.4CDK4, CDKN2A, KITLG, KIT, FAS
4MP:00053818.3ERBB2, KIT, KITLG, CDK4, FAS, CDKN2A
5MP:00053678.1MTOR, CSF3, FAS, KIT, CDK4, CDKN2B
6MP:00053908.0CDKN2A, ERBB2, KITLG, KIT, EWSR1, MTOR
7MP:00053887.9CDKN2A, MTOR, FAS, ERBB2, KIT, MAPK1
8MP:00053797.9KIT, FAS, CDKN2B, CDK4, CDKN2A, ERBB2
9MP:00053707.5CDKN2A, CDK4, KITLG, KIT, MAPK1, FAS
10MP:00053867.4ERBB2, CDKN2A, CDK4, MAPK1, FAS, MTOR
11MP:00053897.3CDKN2B, EWSR1, CDK4, FAS, CDKN2A, ERBB2
12MP:00053857.2CDK4, ERBB2, KITLG, KIT, MAPK1, FLI1
13MP:00053697.1FLI1, KIT, MTOR, CDKN2A, CDK4, EWSR1
14MP:00053807.0CDK4, KITLG, CDKN2A, FLI1, ERBB2, MTOR
15MP:00053767.0FAS, CDKN2B, CDK4, CDKN2A, KITLG, KIT
16MP:00107716.8FAS, MAPK1, CDKN2B, CSF3, EWSR1, KIT
17MP:00036316.5FAS, KIT, MTOR, CDK4, CDKN2A, ERBB2
18MP:00020066.5KIT, CDKN2A, CDK4, ERBB2, KITLG, MAPK1
19MP:00053786.3FLI1, FAS, CDKN2A, KIT, MAPK1, MTOR
20MP:00053976.1CDKN2B, CDK4, CDKN2A, KITLG, KIT, CSF3
21MP:00053876.1CDK4, MTOR, KITLG, CDKN2B, CDKN2A, KIT
22MP:00053846.1FAS, FLI1, EWSR1, MAPK1, MTOR, CDKN2B
23MP:00107686.1KIT, KITLG, ERBB2, CDKN2A, CDK4, MAPK1

Publications for Ewing's Family of Tumors

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Articles related to Ewing's Family of Tumors:

(show all 13)
idTitleAuthorsYear
1
High-dose chemotherapy and stem cell rescue for high-risk Ewing's family of tumors. (21342043)
2011
2
Ewing's family of tumors of the sinonasal tract and maxillary bone. (21107767)
2011
3
Immunophenotypic profile of biomarkers related to anti-apoptotic and neural development pathways in the Ewing's family of tumors (EFT) and their therapeutic implications. (17695539)
2007
4
Prognostic and therapeutic targets in the Ewing's family of tumors (PROTHETS). (17163151)
2006
5
Single center experience of treatment of Ewing's family of tumors in Japan. (16437346)
2006
6
High-dose therapy and stem-cell rescue for Ewing's family of tumors in second remission. (15781877)
2005
7
EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. (15930281)
2005
8
Megatherapy and stem cell transplantation for Ewing's family of tumors: a critical review of current literature. (15125709)
2004
9
Single center experience of a new intensive induction therapy for ewing's family of tumors: feasibility, toxicity, and stem cell mobilization properties. (12885818)
2003
10
Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults. (12972518)
2003
11
Ewing's family of tumors involving structures related to the central nervous system: a review. (10742406)
2000
12
Chemotherapy dose-intensification for pediatric patients with Ewing's family of tumors and desmoplastic small round-cell tumors: a feasibility study at St. Jude Children's Research Hospital. (10458232)
1999
13
Ewing's family of tumors in adults: multivariate analysis of survival and long-term results of multimodality therapy in 182 patients. (9850016)
1998

Variations for Ewing's Family of Tumors

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Expression for genes affiliated with Ewing's Family of Tumors

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Search GEO for disease gene expression data for Ewing's Family of Tumors.

Pathways for genes affiliated with Ewing's Family of Tumors

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Pathways related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation59
9.4CDKN2B, CDK4, CDKN2A
2
Show member pathways
9.4CDK4, CDKN2B, CDKN2A
3
Show member pathways
9.4CDK4, CDKN2A, CDKN2B
49.3ERBB2, KITLG, KIT
59.3CSF3, KITLG, KIT
6
Show member pathways
DNA damage response36
9.3CDKN2A, FAS, CDK4
79.3CDK4, ERBB2, MTOR
89.2KIT, MAPK1, KITLG
9
Show member pathways
9.2KIT, MAPK1, KITLG
10
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)36
9.2KITLG, KIT, MAPK1
11
Show member pathways
Cell cycle36
9.2KITLG, CDKN2B, CDKN2A, CDK4
129.2MAPK1, MTOR, CDK4
13
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes59
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway59
9.2MTOR, CDK4, MAPK1
149.2MTOR, CDK4, MAPK1
15
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.2CDK4, MAPK1, MTOR
169.1CDK4, CDKN2A, MAPK1
179.1MTOR, MAPK1, CDKN2A
189.0CDKN2B, ERBB2, MAPK1
199.0ERBB2, MAPK1, MTOR
20
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.0MAPK1, ERBB2, MTOR
21
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling59
Leptin signaling pathway36
9.0MAPK1, ERBB2, MTOR
229.0ERBB2, MAPK1, MTOR
23
Show member pathways
Translation Non genomic rapid action of Androgen Receptor59
9.0MTOR, ERBB2, MAPK1
24
Show member pathways
9.0ERBB2, KITLG, KIT, MTOR
25
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.9CDKN2A, ERBB2, MAPK1
268.8CDKN2B, CDKN2A, MAPK1, CDK4
27
Show member pathways
8.8CDKN2A, MAPK1, CDKN2B, CDK4
288.8CDKN2B, CDK4, CDKN2A, MAPK1
29
Show member pathways
8.8MAPK1, CDK4, CDKN2A, CDKN2B
30
Show member pathways
8.7KITLG, MAPK1, KIT, ERBB2
31
Show member pathways
8.7ERBB2, MAPK1, KIT, KITLG
32
Show member pathways
8.7KITLG, KIT, MAPK1, ERBB2
33
Show member pathways
Signal transduction PTEN pathway59
8.6MAPK1, MTOR, ERBB2, KIT
34
Show member pathways
8.6CDKN2A, ERBB2, MAPK1, CDK4
358.6KITLG, KIT, FAS, FLI1
368.5MTOR, MAPK1, ERBB2, CDKN2A
378.5FAS, MAPK1, ERBB2, MTOR
38
Show member pathways
8.3ERBB2, KITLG, MAPK1, MTOR, KIT
39
Show member pathways
8.3KITLG, KIT, MAPK1, MTOR, ERBB2
40
Show member pathways
8.3MAPK1, KITLG, ERBB2, KIT, CDKN2A
418.3CDKN2B, FAS, MAPK1, ERBB2, CDK4
42
Show member pathways
8.2MAPK1, CSF3, KIT, ERBB2, KITLG
438.0KIT, CDKN2B, ERBB2, MTOR, MAPK1, KITLG
44
Show member pathways
8.0CDKN2B, MAPK1, MTOR, KIT, ERBB2, KITLG
458.0MTOR, CDK4, KIT, CSF3, MAPK1, KITLG
46
Show member pathways
Signaling Pathways in Glioblastoma36
7.9MTOR, MAPK1, ERBB2, CDKN2A, CDK4, CDKN2B
47
Show member pathways
7.7FAS, ERBB2, KITLG, KIT, CSF3, MAPK1
48
Show member pathways
7.7MAPK1, KIT, KITLG, ERBB2, CDK4, CDKN2B
49
Show member pathways
7.1KITLG, MAPK1, CSF3, KIT, CDK4, CDKN2B
506.8CDK4, KIT, MAPK1, MTOR, FAS, KITLG

Compounds for genes affiliated with Ewing's Family of Tumors

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Compounds related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1ag-1296449.5KIT, MAPK1, KITLG
2flavopiridol44 1110.2CDKN2A, KIT, ERBB2, CDK4
3daunorubicin44 50 1111.1FAS, CSF3, KITLG, CDKN2A
4hydroxyurea44 50 1111.1CSF3, CDKN2A, KITLG, KIT
5carboplatin44 50 1111.1CSF3, ERBB2, KITLG, CDK4
6gp 130449.0KIT, FAS, CSF3, KITLG
7erlotinib44 50 1111.0MTOR, MAPK1, KIT, ERBB2
8irinotecan44 50 1111.0ERBB2, KIT, CDKN2A, CSF3
9everolimus44 50 1110.9KIT, MTOR, ERBB2
10geldanamycin44 50 60 1111.9MAPK1, KIT, CDK4, ERBB2
11sp 60012544 609.8CDK4, FAS, MTOR, MAPK1
12agar448.8CDK4, CDKN2A, ERBB2, FAS, KITLG
13thymidylate448.8FAS, ERBB2, CDK4, CDKN2A
14valine448.7CDK4, CDKN2A, ERBB2, KIT, CSF3
15gefitinib44 50 1110.7MAPK1, ERBB2, CDK4, MTOR, KIT
16docetaxel44 50 60 1111.7CDKN2A, MTOR, CSF3, KIT, ERBB2
17butyrate448.7CDKN2A, FAS, CDK4, MAPK1, KITLG
18arsenite44 249.7CDKN2B, MTOR, MAPK1, CDKN2A, FAS
19herbimycin a44 609.6FAS, MAPK1, KITLG, ERBB2, CDK4
20trastuzumab44 50 1110.6KIT, FAS, MAPK1, CDK4, ERBB2
21cytarabine44 50 1110.6FAS, KITLG, KIT, CDKN2A, CDKN2B, CSF3
22resveratrol44 60 24 1111.6CDK4, ERBB2, MAPK1, MTOR, FAS
23egcg448.5MAPK1, FAS, ERBB2, CDKN2A, CDK4
24methotrexate50 44 1110.5CDKN2A, CDKN2B, KITLG, ERBB2, KIT, CSF3
25steroid448.5KIT, MTOR, ERBB2, CDKN2A, CDK4, KITLG
26n acetylcysteine448.4CDK4, CDKN2A, ERBB2, FAS, MAPK1
27actinomycin d448.4CDKN2A, MAPK1, KIT, KITLG, FAS
28wortmannin448.3FAS, ERBB2, KITLG, MAPK1, MTOR
29paraffin448.3KIT, FAS, CDK4, EWSR1, KITLG, ERBB2
30ly294002448.3MAPK1, KITLG, ERBB2, CDK4, FAS, MTOR
31thymidine44 249.3FAS, MAPK1, CSF3, KIT, KITLG, CDK4
32imatinib44 50 1110.2CSF3, KITLG, MTOR, MAPK1, ERBB2, KIT
33pd 98,059448.2MAPK1, KITLG, FAS, CDK4, KIT, MTOR
34testosterone44 60 24 1111.2MTOR, KIT, CDK4, KITLG, ERBB2, CDKN2A
35oligonucleotide448.1FAS, KIT, CDKN2A, CDK4, EWSR1, FLI1
36arginine448.0ERBB2, EWSR1, CDK4, CDKN2A, FAS, MTOR
37rapamycin448.0FAS, CDK4, KITLG, KIT, MAPK1, MTOR
38phosphatidylinositol447.9FAS, MAPK1, KIT, ERBB2, CDK4, MTOR
39genistein44 28 60 1 24 1112.9CDKN2A, ERBB2, FAS, KITLG, MAPK1, MTOR
405fluorouracil447.7KIT, CDK4, CDKN2A, KITLG, FAS, MTOR
41estrogen447.7MTOR, CDKN2A, MAPK1, CDKN2B, ERBB2, CDK4
42doxorubicin44 50 119.7ERBB2, CDK4, KITLG, KIT, CSF3, MTOR
43paclitaxel44 50 119.4KIT, CSF3, MAPK1, KITLG, ERBB2, CDKN2A
44cycloheximide447.4KITLG, FAS, ERBB2, CDKN2A, CDK4, MAPK1
45cisplatin44 50 60 1110.4MAPK1, FAS, CSF3, MTOR, CDKN2A, KITLG
46dexamethasone44 50 28 1110.4CDK4, CDKN2A, ERBB2, KITLG, CSF3, FAS
47vegf447.1CDK4, FAS, CDKN2A, ERBB2, KITLG, KIT
48retinoic acid44 248.0CSF3, KIT, KITLG, CDKN2A, MAPK1, MTOR
49tyrosine446.9CSF3, CDKN2B, MAPK1, KIT, FAS, EWSR1
50serine446.2EWSR1, FAS, MTOR, MAPK1, KIT, KITLG

GO Terms for genes affiliated with Ewing's Family of Tumors

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Cellular components related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058298.0MTOR, MAPK1, CDKN2A, CDK4, CDKN2B, FAS
2cytoplasmGO:00057377.1CDKN2B, EWSR1, FAS, MTOR, MAPK1, KITLG
3nucleusGO:00056346.5EWSR1, FLI1, FAS, MAPK1, ERBB2, CDKN2A

Biological processes related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:003523410.1KIT, KITLG
2embryonic hemopoiesisGO:003516210.0KIT, KITLG
3somatic stem cell divisionGO:004810310.0KIT, CDKN2A
4negative regulation of phosphorylationGO:00423269.9CDKN2A, CDKN2B
5positive regulation of transcription from RNA polymerase III promoterGO:00459459.9ERBB2, MTOR
6negative regulation of immature T cell proliferation in thymusGO:00330889.8CDKN2A, ERBB2
7extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.7KITLG, FAS
8signal transduction by phosphorylationGO:00230149.7ERBB2, KIT
9spleen developmentGO:00485369.7FAS, CDKN2B
10positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6MTOR, CSF3, KITLG
11regulation of protein stabilityGO:00316479.5CDKN2A, MAPK1
12protein autophosphorylationGO:00467779.4ERBB2, KIT, MTOR
13peptidyl-threonine phosphorylationGO:00181079.4MAPK1, MTOR
14response to toxic substanceGO:00096369.4CDK4, MAPK1, FAS
15positive regulation of actin filament polymerizationGO:00308389.3CSF3, MTOR
16phosphatidylinositol-mediated signalingGO:00480159.3KIT, MTOR, KITLG, ERBB2
17positive regulation of translationGO:00457279.0CDK4, ERBB2, MAPK1, MTOR
18positive regulation of cell proliferationGO:00082848.9CDK4, MAPK1, CSF3, KIT
19fibroblast growth factor receptor signaling pathwayGO:00085438.7KIT, MTOR, MAPK1, KITLG, ERBB2
20Fc-epsilon receptor signaling pathwayGO:00380958.7KITLG, KIT, MAPK1, MTOR, ERBB2
21epidermal growth factor receptor signaling pathwayGO:00071738.7KIT, ERBB2, KITLG, MTOR, MAPK1
22neurotrophin TRK receptor signaling pathwayGO:00480118.7MTOR, ERBB2, MAPK1, KIT, KITLG
23innate immune responseGO:00450878.6MAPK1, ERBB2, MTOR, KITLG, KIT
24signal transductionGO:00071657.9KIT, ERBB2, KITLG, MTOR, FAS, CDK4

Molecular functions related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.7CDKN2B, CDKN2A
2receptor signaling protein tyrosine kinase activityGO:00047169.6KIT, ERBB2
3transmembrane receptor protein tyrosine kinase activityGO:00047149.6ERBB2, KIT
4ATP bindingGO:00055248.0MTOR, MAPK1, KIT, ERBB2, CDK4
5protein bindingGO:00055156.6CDKN2B, EWSR1, FAS, MTOR, MAPK1, KIT

Sources for Ewing's Family of Tumors

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet