MCID: EWN002
MIFTS: 51

Ewing's Family of Tumors malady

Genetic diseases, Rare diseases, Neuronal diseases, Bone diseases, Cancer diseases categories
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Summaries for Ewing's Family of Tumors

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MalaCards based summary: Ewing's Family of Tumors, also known as primitive neuroectodermal tumor, is related to cerebral primitive neuroectodermal tumor and medulloblastoma. An important gene associated with Ewing's Family of Tumors is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are E2F mediated regulation of DNA replication and Cyclins and Cell Cycle Regulation. The drugs cyclophosphamide and etoposide and the compounds ag-1296 and flavopiridol have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Aliases & Classifications for Ewing's Family of Tumors

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Ewing's Family of Tumors, Aliases & Descriptions:

Name: Ewing's Family of Tumors 42 62
Primitive Neuroectodermal Tumor 42 10
Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor 62
Ewing’s Tumor of Bone 42
 
Extraosseous Ewing’s 42
Ewing Family of Tumors 42
Askin’s Tumor 42


Classifications:



Related Diseases for Ewing's Family of Tumors

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Diseases related to Ewing's Family of Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral primitive neuroectodermal tumor31.9FLI1, EWSR1
2medulloblastoma31.6ERBB2, CDK4, CDKN2B
3neuroepithelioma31.4EWSR1, MAPK1, KITLG
4rhabdomyosarcoma31.2CDK4, FLI1, EWSR1
5neuroectodermal tumor31.1FLI1, EWSR1
6embryonal rhabdomyosarcoma31.1EWSR1, CDK4
7synovial sarcoma30.9FLI1, KIT
8lymphoblastic lymphoma30.9FLI1, CDKN2B
9peripheral primitive neuroectodermal tumor30.9EWSR1, FLI1
10neurofibroma30.8KIT, KITLG
11neurofibromatosis30.7KITLG, KIT
12gastrointestinal stromal tumor30.7KIT, KITLG
13astrocytoma30.7CDKN2B, CDK4, CDKN2A, MAPK1
14osteosarcoma30.2CDK4, CDKN2A, MAPK1, FAS
15retinoblastoma30.1MTOR, MAPK1, ERBB2, CDKN2A, CDK4, CDKN2B
16sarcoma30.1EWSR1, FLI1, MTOR, KIT, KITLG, CDK4
17myelodysplastic syndromes30.0FAS, CSF3, KIT, KITLG, CDKN2B
18acute lymphoblastic leukemia29.8CSF3, KIT, KITLG, CDKN2A, CDK4, CDKN2B
19malignant glioma29.7FAS, MTOR, MAPK1, CDKN2A, CDK4, CDKN2B
20breast cancer29.7CDK4, ERBB2, MAPK1, MTOR, FAS
21myeloid leukemia29.5FAS, MAPK1, CSF3, KIT, KITLG, CDK4
22glioblastoma29.3FAS, MTOR, MAPK1, KIT, ERBB2, CDKN2A
23leukemia28.9CDKN2B, EWSR1, FLI1, CDK4, CDKN2A, KITLG
24melanoma28.9EWSR1, FLI1, FAS, MTOR, MAPK1, KIT
25supratentorial primitive neuroectodermal tumor11.1
26extraosseous ewing's sarcoma11.1
27askin's tumor10.9
28cerebritis10.9
29rhabdoid tumor10.8
30teratoma10.7
31atypical teratoid rhabdoid tumor10.6
32cervicitis10.6
33pineoblastoma10.6
34germ cell tumors10.6
35intracranial primitive neuroectodermal tumor10.5
36neuronitis10.5
37childhood medulloblastoma10.5
38thyroiditis10.5
39adult acute lymphocytic leukemia10.5CDKN2B
40cystic teratoma10.5
41prostatitis10.5
42ependymoma10.5
43supratentorial primitive neuroectodermal tumors, childhood10.5
44connective tissue benign neoplasm10.4EWSR1, FLI1
45ganglioglioma10.4
46trilateral retinoblastoma10.4
47unilateral retinoblastoma10.4
48cauda equina syndrome10.4
49bone ewing's sarcoma10.4
50mediastinitis10.4

Graphical network of the top 20 diseases related to Ewing's Family of Tumors:



Diseases related to ewing's family of tumors

Symptoms for Ewing's Family of Tumors

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Drugs & Therapeutics for Ewing's Family of Tumors

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Drug clinical trials:

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Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Ewing's Family of Tumors

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Anatomical Context for Ewing's Family of Tumors

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MalaCards organs/tissues related to Ewing's Family of Tumors:

32
Bone

Animal Models for Ewing's Family of Tumors or affiliated genes

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MGI Mouse Phenotypes related to Ewing's Family of Tumors:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9FAS, KIT, KITLG, CDKN2A
2MP:00053718.9ERBB2, KITLG, KIT, FAS
3MP:00053918.4FAS, KIT, KITLG, CDKN2A, CDK4
4MP:00053818.3FAS, KIT, KITLG, ERBB2, CDKN2A, CDK4
5MP:00053678.1EWSR1, FAS, MTOR, CSF3, KIT, CDK4
6MP:00053908.0EWSR1, FAS, MTOR, KIT, KITLG, ERBB2
7MP:00053887.9FAS, MTOR, MAPK1, KIT, ERBB2, CDKN2A
8MP:00053797.9EWSR1, FAS, KIT, KITLG, ERBB2, CDKN2A
9MP:00053707.5FLI1, FAS, MAPK1, KIT, KITLG, CDKN2A
10MP:00053867.4FAS, MTOR, MAPK1, KIT, ERBB2, CDKN2A
11MP:00053897.3EWSR1, FAS, MAPK1, KIT, KITLG, ERBB2
12MP:00053857.2FLI1, FAS, MAPK1, KIT, KITLG, ERBB2
13MP:00053697.1EWSR1, FLI1, MTOR, MAPK1, KIT, ERBB2
14MP:00053807.0FLI1, MTOR, MAPK1, KIT, KITLG, ERBB2
15MP:00053767.0FAS, MTOR, MAPK1, KIT, KITLG, ERBB2
16MP:00107716.8EWSR1, FAS, MAPK1, CSF3, KIT, KITLG
17MP:00036316.5FLI1, FAS, MTOR, MAPK1, KIT, KITLG
18MP:00020066.5CDKN2B, EWSR1, FLI1, FAS, MAPK1, KIT
19MP:00053786.3EWSR1, FLI1, FAS, MTOR, MAPK1, KIT
20MP:00053976.1MTOR, FAS, FLI1, EWSR1, MAPK1, CSF3
21MP:00053876.1MTOR, FAS, FLI1, EWSR1, MAPK1, CSF3
22MP:00053846.1MTOR, FAS, FLI1, EWSR1, MAPK1, KIT
23MP:00107686.1MTOR, FAS, FLI1, EWSR1, MAPK1, KIT

Publications for Ewing's Family of Tumors

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Articles related to Ewing's Family of Tumors:

(show all 13)
idTitleAuthorsYear
1
High-dose chemotherapy and stem cell rescue for high-risk Ewing's family of tumors. (21342043)
2011
2
Ewing's family of tumors of the sinonasal tract and maxillary bone. (21107767)
2011
3
Immunophenotypic profile of biomarkers related to anti-apoptotic and neural development pathways in the Ewing's family of tumors (EFT) and their therapeutic implications. (17695539)
2007
4
Prognostic and therapeutic targets in the Ewing's family of tumors (PROTHETS). (17163151)
2006
5
Single center experience of treatment of Ewing's family of tumors in Japan. (16437346)
2006
6
High-dose therapy and stem-cell rescue for Ewing's family of tumors in second remission. (15781877)
2005
7
EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. (15930281)
2005
8
Megatherapy and stem cell transplantation for Ewing's family of tumors: a critical review of current literature. (15125709)
2004
9
Single center experience of a new intensive induction therapy for ewing's family of tumors: feasibility, toxicity, and stem cell mobilization properties. (12885818)
2003
10
Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults. (12972518)
2003
11
Ewing's family of tumors involving structures related to the central nervous system: a review. (10742406)
2000
12
Chemotherapy dose-intensification for pediatric patients with Ewing's family of tumors and desmoplastic small round-cell tumors: a feasibility study at St. Jude Children's Research Hospital. (10458232)
1999
13
Ewing's family of tumors in adults: multivariate analysis of survival and long-term results of multimodality therapy in 182 patients. (9850016)
1998

Variations for Ewing's Family of Tumors

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Expression for genes affiliated with Ewing's Family of Tumors

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Expression patterns in normal tissues for genes affiliated with Ewing's Family of Tumors

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Pathways for genes affiliated with Ewing's Family of Tumors

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Pathways related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CDKN2A, CDK4, CDKN2B
2
Show member pathways
9.4CDKN2B, CDK4, CDKN2A
3
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.4CDKN2B, CDK4, CDKN2A
49.3ERBB2, KITLG, KIT
59.3KITLG, KIT, CSF3
6
Show member pathways
DNA damage response37
9.3FAS, CDKN2A, CDK4
79.3MTOR, ERBB2, CDK4
8
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)37
9.2MAPK1, KIT, KITLG
9
Show member pathways
9.2MAPK1, KIT, KITLG
109.2KITLG, KIT, MAPK1
11
Show member pathways
Cell cycle37
9.2CDKN2B, CDK4, CDKN2A, KITLG
12
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
9.2CDK4, MAPK1, MTOR
139.2MTOR, MAPK1, CDK4
149.2MTOR, MAPK1, CDK4
15
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.2CDK4, MAPK1, MTOR
169.1CDK4, CDKN2A, MAPK1
179.1MTOR, MAPK1, CDKN2A
189.0MAPK1, ERBB2, CDKN2B
199.0ERBB2, MAPK1, MTOR
20
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.0MTOR, MAPK1, ERBB2
21
Show member pathways
Prolactin Signaling Pathway37
Development Prolactin receptor signaling60
Leptin signaling pathway37
9.0MTOR, MAPK1, ERBB2
229.0ERBB2, MAPK1, MTOR
23
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.0MTOR, MAPK1, ERBB2
24
Show member pathways
9.0ERBB2, KITLG, KIT, MTOR
25
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
8.9MAPK1, ERBB2, CDKN2A
26
Show member pathways
8.8CDKN2B, CDK4, CDKN2A, MAPK1
278.8MAPK1, CDKN2A, CDK4, CDKN2B
28
Show member pathways
8.8MAPK1, CDKN2A, CDK4, CDKN2B
298.8MAPK1, CDKN2A, CDK4, CDKN2B
30
Show member pathways
8.7ERBB2, KITLG, KIT, MAPK1
31
Show member pathways
8.7MAPK1, KIT, KITLG, ERBB2
32
Show member pathways
8.7MAPK1, KIT, KITLG, ERBB2
33
Show member pathways
Signal transduction PTEN pathway60
8.6MTOR, MAPK1, KIT, ERBB2
34
Show member pathways
8.6MAPK1, ERBB2, CDKN2A, CDK4
358.6FLI1, FAS, KIT, KITLG
368.5CDKN2A, ERBB2, MAPK1, MTOR
378.5FAS, MTOR, MAPK1, ERBB2
38
Show member pathways
8.3ERBB2, KITLG, KIT, MAPK1, MTOR
39
Show member pathways
8.3MTOR, MAPK1, KIT, KITLG, ERBB2
40
Show member pathways
8.3MAPK1, KIT, KITLG, ERBB2, CDKN2A
418.3FAS, MAPK1, ERBB2, CDK4, CDKN2B
42
Show member pathways
8.2MAPK1, CSF3, KIT, KITLG, ERBB2
43
Show member pathways
8.0MTOR, MAPK1, KIT, KITLG, ERBB2, CDKN2B
448.0MTOR, MAPK1, KIT, KITLG, ERBB2, CDKN2B
458.0MTOR, MAPK1, CSF3, KIT, KITLG, CDK4
46
Show member pathways
Signaling Pathways in Glioblastoma37
7.9MTOR, MAPK1, ERBB2, CDKN2A, CDK4, CDKN2B
47
Show member pathways
7.7FAS, MAPK1, CSF3, KIT, KITLG, ERBB2
48
Show member pathways
7.7MAPK1, KIT, KITLG, ERBB2, CDKN2A, CDK4
49
Show member pathways
7.1MAPK1, CSF3, KIT, KITLG, ERBB2, CDKN2A
506.8CDKN2B, FAS, MTOR, MAPK1, KIT, KITLG

Compounds for genes affiliated with Ewing's Family of Tumors

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Compounds related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1ag-1296449.5KIT, MAPK1, KITLG
2flavopiridol44 1110.2CDKN2A, KIT, ERBB2, CDK4
3daunorubicin44 50 1111.1FAS, CSF3, KITLG, CDKN2A
4hydroxyurea44 50 1111.1CSF3, CDKN2A, KITLG, KIT
5carboplatin44 50 1111.1CSF3, ERBB2, KITLG, CDK4
6gp 130449.0KIT, FAS, CSF3, KITLG
7erlotinib44 50 1111.0MTOR, MAPK1, KIT, ERBB2
8irinotecan44 50 1111.0ERBB2, KIT, CDKN2A, CSF3
9everolimus44 50 1110.9KIT, MTOR, ERBB2
10geldanamycin44 50 61 1111.9MAPK1, KIT, CDK4, ERBB2
11sp 60012544 619.8CDK4, FAS, MTOR, MAPK1
12agar448.8CDK4, CDKN2A, ERBB2, FAS, KITLG
13thymidylate448.8FAS, ERBB2, CDK4, CDKN2A
14valine448.7CDK4, CDKN2A, ERBB2, KIT, CSF3
15gefitinib44 50 1110.7MAPK1, ERBB2, CDK4, MTOR, KIT
16docetaxel44 50 61 1111.7CDKN2A, MTOR, CSF3, KIT, ERBB2
17butyrate448.7CDKN2A, FAS, CDK4, MAPK1, KITLG
18arsenite44 249.7CDKN2B, MTOR, MAPK1, CDKN2A, FAS
19herbimycin a44 619.6FAS, MAPK1, KITLG, ERBB2, CDK4
20trastuzumab44 50 1110.6KIT, FAS, MAPK1, CDK4, ERBB2
21cytarabine44 50 1110.6FAS, KITLG, KIT, CDKN2A, CDKN2B, CSF3
22resveratrol44 61 24 1111.6CDK4, ERBB2, MAPK1, MTOR, FAS
23egcg448.5MAPK1, FAS, ERBB2, CDKN2A, CDK4
24methotrexate50 44 1110.5CDKN2A, CDKN2B, KITLG, ERBB2, KIT, CSF3
25steroid448.5KIT, MTOR, ERBB2, CDKN2A, CDK4, KITLG
26n acetylcysteine448.4CDK4, CDKN2A, ERBB2, FAS, MAPK1
27actinomycin d448.4CDKN2A, MAPK1, KIT, KITLG, FAS
28wortmannin448.3FAS, ERBB2, KITLG, MAPK1, MTOR
29paraffin448.3KIT, FAS, CDK4, EWSR1, KITLG, ERBB2
30ly294002448.3MAPK1, KITLG, ERBB2, CDK4, FAS, MTOR
31thymidine44 249.3FAS, MAPK1, CSF3, KIT, KITLG, CDK4
32imatinib44 50 1110.2CSF3, KITLG, MTOR, MAPK1, ERBB2, KIT
33pd 98,059448.2MAPK1, KITLG, FAS, CDK4, KIT, MTOR
34testosterone44 61 24 1111.2MTOR, KIT, CDK4, KITLG, ERBB2, CDKN2A
35oligonucleotide448.1FAS, KIT, CDKN2A, CDK4, EWSR1, FLI1
36arginine448.0ERBB2, EWSR1, CDK4, CDKN2A, FAS, MTOR
37rapamycin448.0FAS, CDK4, KITLG, KIT, MAPK1, MTOR
38phosphatidylinositol447.9FAS, MAPK1, KIT, ERBB2, CDK4, MTOR
39genistein44 28 61 2 24 1112.9CDKN2A, ERBB2, FAS, KITLG, MAPK1, MTOR
405fluorouracil447.7KIT, CDK4, CDKN2A, KITLG, FAS, MTOR
41estrogen447.7MTOR, CDKN2A, MAPK1, CDKN2B, ERBB2, CDK4
42doxorubicin44 50 119.7ERBB2, CDK4, KITLG, KIT, CSF3, MTOR
43paclitaxel44 50 119.4KIT, CSF3, MAPK1, KITLG, ERBB2, CDKN2A
44cycloheximide447.4KITLG, FAS, ERBB2, CDKN2A, CDK4, MAPK1
45cisplatin44 50 61 1110.4MAPK1, FAS, CSF3, MTOR, CDKN2A, KITLG
46dexamethasone44 50 28 1110.4CDK4, CDKN2A, ERBB2, KITLG, CSF3, FAS
47vegf447.1CDK4, FAS, CDKN2A, ERBB2, KITLG, KIT
48retinoic acid44 248.0CSF3, KIT, KITLG, CDKN2A, MAPK1, MTOR
49tyrosine446.9CSF3, CDKN2B, MAPK1, KIT, FAS, EWSR1
50serine446.2EWSR1, FAS, MTOR, MAPK1, KIT, KITLG

GO Terms for genes affiliated with Ewing's Family of Tumors

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Cellular components related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.0MTOR, MAPK1, CDKN2A, CDK4, CDKN2B, FAS
2cytoplasmGO:0057377.1CDKN2B, EWSR1, FAS, MTOR, MAPK1, KITLG
3nucleusGO:0056346.5EWSR1, FLI1, FAS, MAPK1, ERBB2, CDKN2A

Biological processes related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:03523410.1KITLG, KIT
2embryonic hemopoiesisGO:03516210.0KIT, KITLG
3somatic stem cell divisionGO:04810310.0CDKN2A, KIT
4negative regulation of phosphorylationGO:0423269.9CDKN2B, CDKN2A
5negative regulation of immature T cell proliferation in thymusGO:0330889.8CDKN2A, ERBB2
6positive regulation of transcription from RNA polymerase III promoterGO:0459459.8ERBB2, MTOR
7extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7KITLG, FAS
8signal transduction by phosphorylationGO:0230149.7KIT, ERBB2
9spleen developmentGO:0485369.7CDKN2B, FAS
10positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.6MTOR, CSF3, KITLG
11regulation of protein stabilityGO:0316479.5CDKN2A, MAPK1
12protein autophosphorylationGO:0467779.4ERBB2, KIT, MTOR
13peptidyl-threonine phosphorylationGO:0181079.4MTOR, MAPK1
14response to toxic substanceGO:0096369.4CDK4, MAPK1, FAS
15positive regulation of actin filament polymerizationGO:0308389.3CSF3, MTOR
16phosphatidylinositol-mediated signalingGO:0480159.3ERBB2, KITLG, KIT, MTOR
17positive regulation of translationGO:0457279.0CDK4, ERBB2, MAPK1, MTOR
18positive regulation of cell proliferationGO:0082848.9MAPK1, CSF3, KIT, CDK4
19fibroblast growth factor receptor signaling pathwayGO:0085438.7MTOR, MAPK1, KIT, KITLG, ERBB2
20Fc-epsilon receptor signaling pathwayGO:0380958.7ERBB2, KITLG, KIT, MAPK1, MTOR
21epidermal growth factor receptor signaling pathwayGO:0071738.7MTOR, MAPK1, KIT, KITLG, ERBB2
22neurotrophin TRK receptor signaling pathwayGO:0480118.7MTOR, MAPK1, KIT, KITLG, ERBB2
23innate immune responseGO:0450878.6MTOR, MAPK1, KIT, KITLG, ERBB2
24signal transductionGO:0071657.9FAS, MTOR, MAPK1, KIT, KITLG, ERBB2

Molecular functions related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.7CDKN2B, CDKN2A
2receptor signaling protein tyrosine kinase activityGO:0047169.6KIT, ERBB2
3transmembrane receptor protein tyrosine kinase activityGO:0047149.6ERBB2, KIT
4ATP bindingGO:0055248.0MTOR, MAPK1, KIT, ERBB2, CDK4
5protein bindingGO:0055156.6CDKN2B, EWSR1, FAS, MTOR, MAPK1, KIT

Products for genes affiliated with Ewing's Family of Tumors

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  • Antibodies
  • Proteins
  • Lysates

Sources for Ewing's Family of Tumors

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet