Ewing's Family of Tumors disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Ewing's Family of Tumors

MalaCards based summary: Ewing's Family of Tumors, also known as primitive neuroectodermal tumor, is related to cerebral primitive neuroectodermal tumor and medulloblastoma. An important gene associated with Ewing's Family of Tumors is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are E2F mediated regulation of DNA replication and Cyclins and Cell Cycle Regulation. The drugs cyclophosphamide and etoposide and the compounds ag-1296 and flavopiridol have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Aliases & Classifications for Ewing's Family of Tumors

Sources:
⁴²NIH Rare Diseases, ¹¹DISEASES, ⁶¹UMLS
See all sources

Ewing's Family of Tumors, Aliases & Descriptions:

Name: Ewing's Family of Tumors ⁴² ⁶¹

Primitive Neuroectodermal Tumor ⁴² ¹¹

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor ⁶¹

Ewing’s Tumor of Bone ⁴²

Extraosseous Ewing’s ⁴²

Ewing Family of Tumors ⁴²

Askin’s Tumor ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Neuronal diseases, Bone diseases

Related Diseases for Ewing's Family of Tumors

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Ewing's Family of Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 200)

id	Related Disease	Score	Top Affiliating Genes
1	cerebral primitive neuroectodermal tumor	31.9	FLI1, EWSR1
2	medulloblastoma	31.6	ERBB2, CDK4, CDKN2B
3	neuroepithelioma	31.4	EWSR1, MAPK1, KITLG
4	rhabdomyosarcoma	31.2	CDK4, FLI1, EWSR1
5	neuroectodermal tumor	31.1	FLI1, EWSR1
6	embryonal rhabdomyosarcoma	31.1	EWSR1, CDK4
7	synovial sarcoma	30.9	FLI1, KIT
8	lymphoblastic lymphoma	30.9	FLI1, CDKN2B
9	peripheral primitive neuroectodermal tumor	30.9	EWSR1, FLI1
10	neurofibroma	30.8	KIT, KITLG
11	neurofibromatosis	30.7	KITLG, KIT
12	gastrointestinal stromal tumor	30.7	KIT, KITLG
13	astrocytoma	30.7	CDKN2B, CDK4, CDKN2A, MAPK1
14	osteosarcoma	30.2	CDK4, CDKN2A, MAPK1, FAS
15	retinoblastoma	30.1	MTOR, MAPK1, ERBB2, CDKN2A, CDK4, CDKN2B
16	sarcoma	30.1	EWSR1, FLI1, MTOR, KIT, KITLG, CDK4
17	myelodysplastic syndromes	30.0	FAS, CSF3, KIT, KITLG, CDKN2B
18	acute lymphoblastic leukemia	29.8	CSF3, KIT, KITLG, CDKN2A, CDK4, CDKN2B
19	malignant glioma	29.7	FAS, MTOR, MAPK1, CDKN2A, CDK4, CDKN2B
20	breast cancer	29.7	CDK4, ERBB2, MAPK1, MTOR, FAS
21	myeloid leukemia	29.5	FAS, MAPK1, CSF3, KIT, KITLG, CDK4
22	glioblastoma	29.3	FAS, MTOR, MAPK1, KIT, ERBB2, CDKN2A
23	leukemia	28.9	CDKN2B, EWSR1, FLI1, CDK4, CDKN2A, KITLG
24	melanoma	28.9	EWSR1, FLI1, FAS, MTOR, MAPK1, KIT
25	supratentorial primitive neuroectodermal tumor	11.1
26	extraosseous ewing's sarcoma	11.1
27	askin's tumor	10.9
28	cerebritis	10.9
29	rhabdoid tumor	10.8
30	teratoma	10.7
31	atypical teratoid rhabdoid tumor	10.6
32	cervicitis	10.6
33	pineoblastoma	10.6
34	germ cell tumors	10.6
35	intracranial primitive neuroectodermal tumor	10.5
36	neuronitis	10.5
37	childhood medulloblastoma	10.5
38	thyroiditis	10.5
39	adult acute lymphocytic leukemia	10.5	CDKN2B
40	cystic teratoma	10.5
41	prostatitis	10.5
42	ependymoma	10.5
43	supratentorial primitive neuroectodermal tumors, childhood	10.5
44	connective tissue benign neoplasm	10.4	EWSR1, FLI1
45	ganglioglioma	10.4
46	trilateral retinoblastoma	10.4
47	unilateral retinoblastoma	10.4
48	cauda equina syndrome	10.4
49	bone ewing's sarcoma	10.4
50	mediastinitis	10.4

Graphical network of the top 20 diseases related to Ewing's Family of Tumors:

Symptoms for Ewing's Family of Tumors

Drugs & Therapeutics for Ewing's Family of Tumors

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Ewing's Family of Tumors

Search NIH Clinical Center for Ewing's Family of Tumors

Inferred drug relations via UMLS⁶¹/NDF-RT⁴⁰:

cyclophosphamide

etoposide

etoposide phosphate

Genetic Tests for Ewing's Family of Tumors

Anatomical Context for Ewing's Family of Tumors

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Ewing's Family of Tumors:

³²

Bone

Animal Models for Ewing's Family of Tumors or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Ewing's Family of Tumors:

³⁶ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation phenotype	MP:0001186	8.9	FAS, KIT, KITLG, CDKN2A
2	limbs/digits/tail phenotype	MP:0005371	8.9	ERBB2, KITLG, KIT, FAS
3	vision/eye phenotype	MP:0005391	8.4	FAS, KIT, KITLG, CDKN2A, CDK4
4	digestive/alimentary phenotype	MP:0005381	8.3	FAS, KIT, KITLG, ERBB2, CDKN2A, CDK4
5	renal/urinary system phenotype	MP:0005367	8.1	EWSR1, FAS, MTOR, CSF3, KIT, CDK4
6	skeleton phenotype	MP:0005390	8.0	EWSR1, FAS, MTOR, KIT, KITLG, ERBB2
7	respiratory system phenotype	MP:0005388	7.9	FAS, MTOR, MAPK1, KIT, ERBB2, CDKN2A
8	endocrine/exocrine gland phenotype	MP:0005379	7.9	EWSR1, FAS, KIT, KITLG, ERBB2, CDKN2A
9	liver/biliary system phenotype	MP:0005370	7.5	FLI1, FAS, MAPK1, KIT, KITLG, CDKN2A
10	behavior/neurological phenotype	MP:0005386	7.4	FAS, MTOR, MAPK1, KIT, ERBB2, CDKN2A
11	reproductive system phenotype	MP:0005389	7.3	EWSR1, FAS, MAPK1, KIT, KITLG, ERBB2
12	cardiovascular system phenotype	MP:0005385	7.2	FLI1, FAS, MAPK1, KIT, KITLG, ERBB2
13	muscle phenotype	MP:0005369	7.1	EWSR1, FLI1, MTOR, MAPK1, KIT, ERBB2
14	embryogenesis phenotype	MP:0005380	7.0	FLI1, MTOR, MAPK1, KIT, KITLG, ERBB2
15	homeostasis/metabolism phenotype	MP:0005376	7.0	FAS, MTOR, MAPK1, KIT, KITLG, ERBB2
16	integument phenotype	MP:0010771	6.8	EWSR1, FAS, MAPK1, CSF3, KIT, KITLG
17	nervous system phenotype	MP:0003631	6.5	FLI1, FAS, MTOR, MAPK1, KIT, KITLG
18	tumorigenesis	MP:0002006	6.5	CDKN2B, EWSR1, FLI1, FAS, MAPK1, KIT
19	growth/size/body phenotype	MP:0005378	6.3	EWSR1, FLI1, FAS, MTOR, MAPK1, KIT
20	hematopoietic system phenotype	MP:0005397	6.1	MTOR, FAS, FLI1, EWSR1, MAPK1, CSF3
21	immune system phenotype	MP:0005387	6.1	MTOR, FAS, FLI1, EWSR1, MAPK1, CSF3
22	cellular phenotype	MP:0005384	6.1	MTOR, FAS, FLI1, EWSR1, MAPK1, KIT
23	mortality/aging	MP:0010768	6.1	MTOR, FAS, FLI1, EWSR1, MAPK1, KIT

Publications for Ewing's Family of Tumors

Sources:
⁵¹PubMed
See all sources

Articles related to Ewing's Family of Tumors:

(show all 13)

id	Title	Authors	Year
1	High-dose chemotherapy and stem cell rescue for high-risk Ewing's family of tumors. (21342043)	Rosenthal J.... Pawlowska A.B.	2011
2	Ewing's family of tumors of the sinonasal tract and maxillary bone. (21107767)	Hafezi S.... Weinreb I.	2011
3	Immunophenotypic profile of biomarkers related to anti-apoptotic and neural development pathways in the Ewing's family of tumors (EFT) and their therapeutic implications. (17695539)	Navarro S.... Llombart-Bosch A.	2007
4	Prognostic and therapeutic targets in the Ewing's family of tumors (PROTHETS). (17163151)	Picci P.... Rizzi A.	2006
5	Single center experience of treatment of Ewing's family of tumors in Japan. (16437346)	Yamada K.... Takahashi M.	2006
6	High-dose therapy and stem-cell rescue for Ewing's family of tumors in second remission. (15781877)	Marina N.... Meyers P.A.	2005
7	EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. (15930281)	Hu-Lieskovan S.... Triche T.J.	2005
8	Megatherapy and stem cell transplantation for Ewing's family of tumors: a critical review of current literature. (15125709)	Kalambakas S.A.... Feig S.A.	2004
9	Single center experience of a new intensive induction therapy for ewing's family of tumors: feasibility, toxicity, and stem cell mobilization properties. (12885818)	Strauss S.J.... Whelan J.S.	2003
10	Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults. (12972518)	Kolb E.A.... Meyers P.A.	2003
11	Ewing's family of tumors involving structures related to the central nervous system: a review. (10742406)	Hadfield M.G.... Luo V.Y.	2000
12	Chemotherapy dose-intensification for pediatric patients with Ewing's family of tumors and desmoplastic small round-cell tumors: a feasibility study at St. Jude Children's Research Hospital. (10458232)	Marina N.M.... Meyer W.H.	1999
13	Ewing's family of tumors in adults: multivariate analysis of survival and long-term results of multimodality therapy in 182 patients. (9850016)	Fizazi K.... Nguyen B.B.	1998

Genes related to Ewing's Family of Tumors

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Ewing's Family of Tumors:

(show all 12)

- Elite gene

id	Symbol	Description	Score	Implication
1	EWSR1	EWS RNA-binding protein 1	20.15	GeneCards inferred via : Publications (show sections)
2	KITLG	KIT ligand	18.39	GeneCards inferred via : Publications (show sections)
3	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	16.71	GeneCards inferred via : Publications (show sections)
4	CDK4	cyclin-dependent kinase 4	15.01	GeneCards inferred via : Publications (show sections)
5	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	13.32	GeneCards inferred via : Publications (show sections)
6	MTOR	mechanistic target of rapamycin (serine/threonine kinase)	11.65	GeneCards inferred via : Publications (show sections)
7	CDKN2A	cyclin-dependent kinase inhibitor 2A	9.96	GeneCards inferred via : Publications (show sections)
8	FAS	Fas cell surface death receptor	8.29	GeneCards inferred via : Publications (show sections)
9	ERBB2	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	6.61	GeneCards inferred via : Publications (show sections)
10	MAPK1	mitogen-activated protein kinase 1	4.93	GeneCards inferred via : Publications (show sections)
11	FLI1	Fli-1 proto-oncogene, ETS transcription factor	3.43	GeneCards inferred via : Publications (show sections)
12	CSF3	colony stimulating factor 3 (granulocyte)	1.63	GeneCards inferred via : Publications (show sections)

Products for genes related to Ewing's Family of Tumors disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	11	-	11	11
2	Novus Biologicals	11	12	12	-

Variations for Ewing's Family of Tumors

Expression for genes affiliated with Ewing's Family of Tumors

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Ewing's Family of Tumors

Search GEO for disease gene expression data for Ewing's Family of Tumors.

Pathways for genes affiliated with Ewing's Family of Tumors

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ³⁷NCBI BioSystems Database, ⁵²QIAGEN, ⁵⁹Thomson Reuters, ⁵Cell Signaling Technology, ³⁰KEGG, ⁵³R&D Systems, ⁵⁰PharmGKB, ⁵⁵SinoBiological
See all sources

Pathways related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show top 50) (show all 65)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	E2F mediated regulation of DNA replication⁵⁴ Show member pathways E2F-enabled inhibition of pre-replication complex formation⁵⁴ G1/S-Specific Transcription⁵⁴ G1 to S cell cycle control³⁷ G1/S Transition⁵⁴ Mitotic G1-G1/S phases⁵⁴ Inhibition of replication initiation of damaged DNA by RB1/E2F1⁵⁴ Assembly of the ORC complex at the origin of replication⁵⁴	9.4	CDKN2A, CDK4, CDKN2B
2	Cyclins and Cell Cycle Regulation⁵² Show member pathways Cell Cycle Control by BTG Proteins⁵² Phosphorylation of proteins involved in G1/S transition by active Cyclin E-Cdk2 complexes⁵⁴ G1-S Phase Transition⁵² G1 Phase⁵⁴ Cyclin D associated events in G1⁵⁴	9.4	CDKN2B, CDK4, CDKN2A
3	Cell cycle Regulation of G1 S transition part 1 ⁵⁹ Show member pathways Cell cycle Role of SCF complex in cell cycle regulation⁵⁹	9.4	CDKN2B, CDK4, CDKN2A
4	Tyrosine Kinases / Adaptors⁵	9.3	ERBB2, KITLG, KIT
5	Hematopoietic cell lineage³⁰	9.3	KITLG, KIT, CSF3
6	p53 signaling pathway³⁰ Show member pathways DNA damage response³⁷	9.3	FAS, CDKN2A, CDK4
7	Akt Signaling Pathway⁵³	9.3	MTOR, ERBB2, CDK4
8	Kit Receptor Signaling Pathway³⁷ Show member pathways Signaling events mediated by Stem cell factor receptor (c-Kit)³⁷	9.2	MAPK1, KIT, KITLG
9	Basal cell carcinoma³⁰ Show member pathways Hedgehog signaling pathway³⁰ Melanogenesis³⁰	9.2	MAPK1, KIT, KITLG
10	Melanocyte Development and Pigmentation⁵²	9.2	KITLG, KIT, MAPK1
11	Cell cycle³⁰ Show member pathways Cell cycle³⁷	9.2	CDKN2B, CDK4, CDKN2A, KITLG
12	IL-9 Signaling Pathways⁵³ Show member pathways IL-21 Signaling Pathways⁵³ IL-9 Signaling Pathway³⁷ Common Cytokine Receptor Gamma-Chain Family Signaling Pathways⁵³ Development Thrombopoietin regulated cell processes⁵⁹ IL-15 Signaling Pathways⁵³ IL-7 Signaling Pathways⁵³ Adipocytokines and Insulin Signaling⁵³ IL-7 Signaling Pathway³⁷ IL-2 Signaling Pathways⁵³ Immune response IL 9 signaling pathway⁵⁹ IL-4 Signaling Pathways⁵³ IL-9 Pathway⁵²	9.2	CDK4, MAPK1, MTOR
13	Integrated Breast Cancer Pathway³⁷	9.2	MTOR, MAPK1, CDK4
14	TSH signaling pathway³⁷	9.2	MTOR, MAPK1, CDK4
15	Prostate cancer³⁰ Show member pathways Prostate Cancer³⁷ Integrated Cancer pathway³⁷ Steroid Biosynthesis³⁷	9.2	CDK4, MAPK1, MTOR
16	Glioblastoma Multiforme⁵²	9.1	CDK4, CDKN2A, MAPK1
17	Senescence and Autophagy³⁷	9.1	MTOR, MAPK1, CDKN2A
18	Development TGF beta receptor signaling⁵⁹	9.0	MAPK1, ERBB2, CDKN2B
19	HIF-1 signaling pathway³⁰	9.0	ERBB2, MAPK1, MTOR
20	ErbB signaling pathway³⁰ Show member pathways ErbB receptor signaling network³⁷ ErbB signaling pathway³⁷ EGFR Inhibitor Pathway, Pharmacodynamics⁵⁰	9.0	MTOR, MAPK1, ERBB2
21	Prolactin signaling pathway³⁰ Show member pathways Prolactin Signaling Pathway³⁷ Development Prolactin receptor signaling⁵⁹ Leptin signaling pathway³⁷	9.0	MTOR, MAPK1, ERBB2
22	EGFR Signaling Pathway⁵⁵	9.0	ERBB2, MAPK1, MTOR
23	Transcription Androgen Receptor nuclear signaling⁵⁹ Show member pathways Translation Non genomic rapid action of Androgen Receptor⁵⁹	9.0	MTOR, MAPK1, ERBB2
24	Downstream Signaling Events Of B Cell Receptor (BCR)⁵⁴ Show member pathways Signaling by the B Cell Receptor (BCR)⁵⁴ Activation of RAS in B Cells⁵⁴	9.0	ERBB2, KITLG, KIT, MTOR
25	Wnt Signaling Pathway³⁷ Show member pathways DNA damage response (only ATM dependent)³⁷ Wnt Signaling Pathway and Pluripotency³⁷	8.9	MAPK1, ERBB2, CDKN2A
26	Cellular Senescence⁵⁴ Show member pathways Cellular responses to stress⁵⁴ Senescence-Associated Secretory Phenotype (SASP)⁵⁴ Oxidative Stress Induced Senescence⁵⁴	8.8	CDKN2B, CDK4, CDKN2A, MAPK1
27	Oncogene Induced Senescence⁵⁴	8.8	MAPK1, CDKN2A, CDK4, CDKN2B
28	Cell Cycle, Mitotic⁵⁴ Show member pathways Cell Cycle⁵⁴ M Phase⁵⁴	8.8	MAPK1, CDKN2A, CDK4, CDKN2B
29	Viral carcinogenesis³⁰	8.8	MAPK1, CDKN2A, CDK4, CDKN2B
30	Activation of cAMP-Dependent PKA⁵² Show member pathways PKA Signaling⁵² Activation of PKA through GPCR⁵² cAMP Pathway⁵²	8.7	ERBB2, KITLG, KIT, MAPK1
31	Nanog in Mammalian ESC Pluripotency⁵² Show member pathways GSK3 Signaling⁵² eNOS Signaling⁵² 14-3-3 Induced Intracellular Signaling⁵²	8.7	MAPK1, KIT, KITLG, ERBB2
32	CREB Pathway⁵² Show member pathways Intracellular Calcium Signaling⁵² Activation of PKC through GPCR⁵² IP3 Pathway⁵²	8.7	MAPK1, KIT, KITLG, ERBB2
33	Endometrial cancer³⁰ Show member pathways Colorectal cancer³⁰ Signal transduction PTEN pathway⁵⁹ Acute myeloid leukemia³⁰	8.6	MTOR, MAPK1, KIT, ERBB2
34	Chronic myeloid leukemia³⁰ Show member pathways Pancreatic cancer³⁰	8.6	MAPK1, ERBB2, CDKN2A, CDK4
35	Lymphocyte Signaling⁵	8.6	FLI1, FAS, KIT, KITLG
36	MicroRNAs in cancer³⁰	8.5	CDKN2A, ERBB2, MAPK1, MTOR
37	Proteoglycans in cancer³⁰	8.5	FAS, MTOR, MAPK1, ERBB2
38	PI-3K cascade⁵⁴ Show member pathways Downregulation of ERBB4 signaling⁵⁴ AKT phosphorylates targets in the nucleus⁵⁴ Signaling by SCF-KIT⁵⁴ PI3K events in ERBB2 signaling⁵⁴ Fc epsilon receptor (FCERI) signaling⁵⁴ PI3K events in ERBB4 signaling⁵⁴ Signaling by ERBB4⁵⁴ GAB1 signalosome⁵⁴ Negative regulation of the PI3K/AKT network⁵⁴ Role of LAT2/NTAL/LAB on calcium mobilization⁵⁴ PIP3 activates AKT signaling⁵⁴ Regulation of KIT signaling⁵⁴ AKT phosphorylates targets in the cytosol⁵⁴ AKT-mediated inactivation of FOXO1A⁵⁴ PI3K/AKT Signaling in Cancer⁵⁴ Constitutive PI3K/AKT Signaling in Cancer⁵⁴ PI3K/AKT activation⁵⁴	8.3	ERBB2, KITLG, KIT, MAPK1, MTOR
39	Signaling by FGFR⁵⁴ Show member pathways Signaling by constitutively active EGFR⁵⁴ Signaling by EGFR⁵⁴ DAP12 interactions⁵⁴ DAP12 signaling⁵⁴ Signaling by ERBB2⁵⁴ Signaling by FGFR in disease⁵⁴ Signaling by PDGF⁵⁴ Downstream signaling of activated FGFR⁵⁴ Signaling by EGFR in Cancer⁵⁴ Signalling by NGF⁵⁴ Downstream signal transduction⁵⁴ Downregulation of ERBB2-ERBB3 signaling⁵⁴ NGF signalling via TRKA from the plasma membrane⁵⁴	8.3	MTOR, MAPK1, KIT, KITLG, ERBB2
40	Apoptotic Pathways in Synovial Fibroblasts⁵² Show member pathways Actin-Based Motility by Rho Family GTPases⁵² PPAR Pathway⁵² Cellular Apoptosis Pathway⁵² Rac1 Pathway⁵² Glioma Invasiveness⁵² eIF2 Pathway⁵² ERK5 Signaling⁵² p53 Mediated Apoptosis⁵² Mitochondrial Apoptosis⁵² Rap1 Pathway⁵² Telomerase Components in Cell Signaling⁵² Nuclear Receptor Activation by Vitamin-A⁵² DHA Signaling⁵²	8.3	MAPK1, KIT, KITLG, ERBB2, CDKN2A
41	Integrated Pancreatic Cancer Pathway³⁷	8.3	FAS, MAPK1, ERBB2, CDK4, CDKN2B
42	PAK Pathway⁵² Show member pathways Epithelial Adherens Junctions⁵² Antioxidant Action of Vitamin-C⁵²	8.2	MAPK1, CSF3, KIT, KITLG, ERBB2
43	Signaling by GPCR⁵⁴ Show member pathways GPCR downstream signaling⁵⁴ Signal Transduction⁵⁴	8.0	MTOR, MAPK1, KIT, KITLG, ERBB2, CDKN2B
44	Disease⁵⁴	8.0	MTOR, MAPK1, KIT, KITLG, ERBB2, CDKN2B
45	PI3K-Akt signaling pathway³⁰	8.0	MTOR, MAPK1, CSF3, KIT, KITLG, CDK4
46	Glioma³⁰ Show member pathways Melanoma³⁰ Non-small cell lung cancer³⁰ Bladder cancer³⁰ Prostate cancer³⁰ Signaling Pathways in Glioblastoma³⁷	7.9	MTOR, MAPK1, ERBB2, CDKN2A, CDK4, CDKN2B
47	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	7.7	FAS, MAPK1, CSF3, KIT, KITLG, ERBB2
48	GPCR Pathway⁵² Show member pathways Breast Cancer Regulation by Stathmin1⁵² Pancreatic Adenocarcinoma⁵² P2Y Receptor Signaling⁵² Ras Pathway⁵² Paxillin Interactions⁵² NFAT in Immune Response⁵² Estrogen Pathway⁵²	7.7	MAPK1, KIT, KITLG, ERBB2, CDKN2A, CDK4
49	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	7.1	MAPK1, CSF3, KIT, KITLG, ERBB2, CDKN2A
50	Pathways in cancer³⁰	6.8	CDKN2B, FAS, MTOR, MAPK1, KIT, KITLG

Compounds for genes affiliated with Ewing's Family of Tumors

Sources:
⁴⁴Novoseek, ¹²DrugBank, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience, ²⁵HMDB, ²⁹IUPHAR, ³BitterDB
See all sources

Compounds related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show top 50) (show all 150)

id	Compound	Score	Top Affiliating Genes
1	ag-1296⁴⁴	9.5	KIT, MAPK1, KITLG
2	flavopiridol⁴⁴ ¹²	10.2	CDKN2A, KIT, ERBB2, CDK4
3	daunorubicin⁴⁴ ⁵⁰ ¹²	11.1	FAS, CSF3, KITLG, CDKN2A
4	hydroxyurea⁴⁴ ⁵⁰ ¹²	11.1	CSF3, CDKN2A, KITLG, KIT
5	carboplatin⁴⁴ ⁵⁰ ¹²	11.1	CSF3, ERBB2, KITLG, CDK4
6	gp 130⁴⁴	9.0	KIT, FAS, CSF3, KITLG
7	erlotinib⁴⁴ ⁵⁰ ¹²	11.0	MTOR, MAPK1, KIT, ERBB2
8	irinotecan⁴⁴ ⁵⁰ ¹²	11.0	ERBB2, KIT, CDKN2A, CSF3
9	everolimus⁴⁴ ⁵⁰ ¹²	10.9	KIT, MTOR, ERBB2
10	geldanamycin⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.9	MAPK1, KIT, CDK4, ERBB2
11	sp 600125⁴⁴ ⁶⁰	9.8	CDK4, FAS, MTOR, MAPK1
12	agar⁴⁴	8.8	CDK4, CDKN2A, ERBB2, FAS, KITLG
13	thymidylate⁴⁴	8.8	FAS, ERBB2, CDK4, CDKN2A
14	valine⁴⁴	8.7	CDK4, CDKN2A, ERBB2, KIT, CSF3
15	gefitinib⁴⁴ ⁵⁰ ¹²	10.7	MAPK1, ERBB2, CDK4, MTOR, KIT
16	docetaxel⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.7	CDKN2A, MTOR, CSF3, KIT, ERBB2
17	butyrate⁴⁴	8.7	CDKN2A, FAS, CDK4, MAPK1, KITLG
18	arsenite⁴⁴ ²⁵	9.7	CDKN2B, MTOR, MAPK1, CDKN2A, FAS
19	herbimycin a⁴⁴ ⁶⁰	9.6	FAS, MAPK1, KITLG, ERBB2, CDK4
20	trastuzumab⁴⁴ ⁵⁰ ¹²	10.6	KIT, FAS, MAPK1, CDK4, ERBB2
21	cytarabine⁴⁴ ⁵⁰ ¹²	10.6	FAS, KITLG, KIT, CDKN2A, CDKN2B, CSF3
22	resveratrol⁴⁴ ⁶⁰ ²⁵ ¹²	11.6	CDK4, ERBB2, MAPK1, MTOR, FAS
23	egcg⁴⁴	8.5	MAPK1, FAS, ERBB2, CDKN2A, CDK4
24	methotrexate⁵⁰ ⁴⁴ ¹²	10.5	CDKN2A, CDKN2B, KITLG, ERBB2, KIT, CSF3
25	steroid⁴⁴	8.5	KIT, MTOR, ERBB2, CDKN2A, CDK4, KITLG
26	n acetylcysteine⁴⁴	8.4	CDK4, CDKN2A, ERBB2, FAS, MAPK1
27	actinomycin d⁴⁴	8.4	CDKN2A, MAPK1, KIT, KITLG, FAS
28	wortmannin⁴⁴	8.3	FAS, ERBB2, KITLG, MAPK1, MTOR
29	paraffin⁴⁴	8.3	KIT, FAS, CDK4, EWSR1, KITLG, ERBB2
30	ly294002⁴⁴	8.3	MAPK1, KITLG, ERBB2, CDK4, FAS, MTOR
31	thymidine⁴⁴ ²⁵	9.3	FAS, MAPK1, CSF3, KIT, KITLG, CDK4
32	imatinib⁴⁴ ⁵⁰ ¹²	10.2	CSF3, KITLG, MTOR, MAPK1, ERBB2, KIT
33	pd 98,059⁴⁴	8.2	MAPK1, KITLG, FAS, CDK4, KIT, MTOR
34	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	11.2	MTOR, KIT, CDK4, KITLG, ERBB2, CDKN2A
35	oligonucleotide⁴⁴	8.1	FAS, KIT, CDKN2A, CDK4, EWSR1, FLI1
36	arginine⁴⁴	8.0	ERBB2, EWSR1, CDK4, CDKN2A, FAS, MTOR
37	rapamycin⁴⁴	8.0	FAS, CDK4, KITLG, KIT, MAPK1, MTOR
38	phosphatidylinositol⁴⁴	7.9	FAS, MAPK1, KIT, ERBB2, CDK4, MTOR
39	genistein⁴⁴ ²⁹ ⁶⁰ ³ ²⁵ ¹²	12.9	CDKN2A, ERBB2, FAS, KITLG, MAPK1, MTOR
40	5fluorouracil⁴⁴	7.7	KIT, CDK4, CDKN2A, KITLG, FAS, MTOR
41	estrogen⁴⁴	7.7	MTOR, CDKN2A, MAPK1, CDKN2B, ERBB2, CDK4
42	doxorubicin⁴⁴ ⁵⁰ ¹²	9.7	ERBB2, CDK4, KITLG, KIT, CSF3, MTOR
43	paclitaxel⁴⁴ ⁵⁰ ¹²	9.4	KIT, CSF3, MAPK1, KITLG, ERBB2, CDKN2A
44	cycloheximide⁴⁴	7.4	KITLG, FAS, ERBB2, CDKN2A, CDK4, MAPK1
45	cisplatin⁴⁴ ⁵⁰ ⁶⁰ ¹²	10.4	MAPK1, FAS, CSF3, MTOR, CDKN2A, KITLG
46	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	10.4	CDK4, CDKN2A, ERBB2, KITLG, CSF3, FAS
47	vegf⁴⁴	7.1	CDK4, FAS, CDKN2A, ERBB2, KITLG, KIT
48	retinoic acid⁴⁴ ²⁵	8.0	CSF3, KIT, KITLG, CDKN2A, MAPK1, MTOR
49	tyrosine⁴⁴	6.9	CSF3, CDKN2B, MAPK1, KIT, FAS, EWSR1
50	serine⁴⁴	6.2	EWSR1, FAS, MTOR, MAPK1, KIT, KITLG

GO Terms for genes affiliated with Ewing's Family of Tumors

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	8.0	MTOR, MAPK1, CDKN2A, CDK4, CDKN2B, FAS
2	cytoplasm	GO:005737	7.1	CDKN2B, EWSR1, FAS, MTOR, MAPK1, KITLG
3	nucleus	GO:005634	6.5	EWSR1, FLI1, FAS, MAPK1, ERBB2, CDKN2A

Biological processes related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	ectopic germ cell programmed cell death	GO:035234	10.1	KITLG, KIT
2	embryonic hemopoiesis	GO:035162	10.0	KIT, KITLG
3	somatic stem cell division	GO:048103	10.0	CDKN2A, KIT
4	negative regulation of phosphorylation	GO:042326	9.9	CDKN2B, CDKN2A
5	negative regulation of immature T cell proliferation in thymus	GO:033088	9.8	CDKN2A, ERBB2
6	positive regulation of transcription from RNA polymerase III promoter	GO:045945	9.8	ERBB2, MTOR
7	extrinsic apoptotic signaling pathway in absence of ligand	GO:097192	9.7	KITLG, FAS
8	signal transduction by phosphorylation	GO:023014	9.7	KIT, ERBB2
9	spleen development	GO:048536	9.7	CDKN2B, FAS
10	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	MTOR, CSF3, KITLG
11	regulation of protein stability	GO:031647	9.5	CDKN2A, MAPK1
12	protein autophosphorylation	GO:046777	9.4	ERBB2, KIT, MTOR
13	peptidyl-threonine phosphorylation	GO:018107	9.4	MTOR, MAPK1
14	response to toxic substance	GO:009636	9.4	CDK4, MAPK1, FAS
15	positive regulation of actin filament polymerization	GO:030838	9.3	CSF3, MTOR
16	phosphatidylinositol-mediated signaling	GO:048015	9.3	ERBB2, KITLG, KIT, MTOR
17	positive regulation of translation	GO:045727	9.0	CDK4, ERBB2, MAPK1, MTOR
18	positive regulation of cell proliferation	GO:008284	8.9	MAPK1, CSF3, KIT, CDK4
19	fibroblast growth factor receptor signaling pathway	GO:008543	8.7	MTOR, MAPK1, KIT, KITLG, ERBB2
20	Fc-epsilon receptor signaling pathway	GO:038095	8.7	ERBB2, KITLG, KIT, MAPK1, MTOR
21	epidermal growth factor receptor signaling pathway	GO:007173	8.7	MTOR, MAPK1, KIT, KITLG, ERBB2
22	neurotrophin TRK receptor signaling pathway	GO:048011	8.7	MTOR, MAPK1, KIT, KITLG, ERBB2
23	innate immune response	GO:045087	8.6	MTOR, MAPK1, KIT, KITLG, ERBB2
24	signal transduction	GO:007165	7.9	FAS, MTOR, MAPK1, KIT, KITLG, ERBB2

Molecular functions related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO:004861	9.7	CDKN2B, CDKN2A
2	receptor signaling protein tyrosine kinase activity	GO:004716	9.6	KIT, ERBB2
3	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.6	ERBB2, KIT
4	ATP binding	GO:005524	8.0	MTOR, MAPK1, KIT, ERBB2, CDK4
5	protein binding	GO:005515	6.6	CDKN2B, EWSR1, FAS, MTOR, MAPK1, KIT