MCID: EWN002
MIFTS: 48

Ewing's Family of Tumors malady

Genetic diseases, Rare diseases, Neuronal diseases, Bone diseases, Cancer diseases categories
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Summaries for Ewing's Family of Tumors

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33MalaCards
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MalaCards: Ewing's Family of Tumors, also known as extraosseous ewings sarcoma-primitive neuroepithelial tumor, is related to medulloblastoma and cerebral primitive neuroectodermal tumor. An important gene associated with Ewing's Family of Tumors is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and E2F mediated regulation of DNA replication. The compounds ag-1296 and flavopiridol have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Aliases & Classifications for Ewing's Family of Tumors

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43NIH Rare Diseases, 62UMLS
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Classifications:



Aliases & Descriptions:

ewing's family of tumors 43
extraosseous ewings sarcoma-primitive neuroepithelial tumor 62
primitive neuroectodermal tumor 43
ewing’s tumor of bone 43
extraosseous ewing’s 43
ewing family of tumors 43
askin’s tumor 43


Related Diseases for Ewing's Family of Tumors

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17GeneCards, 18GeneDecks
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Diseases in the Ewing's Family of Tumors family:

Ewing's Family Localized Tumor

Diseases related to Ewing's Family of Tumors via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 203)
idRelated DiseaseScoreTop Affiliating Genes
1medulloblastoma31.5ERBB2, CDK4, CDKN2B
2cerebral primitive neuroectodermal tumor31.4FLI1, EWSR1
3neuroepithelioma31.2EWSR1, FLI1
4rhabdomyosarcoma30.8FLI1, EWSR1, CDK4
5embryonal rhabdomyosarcoma30.7EWSR1, CDK4
6astrocytoma30.7MAPK1, CDK4, CDKN2A, CDKN2B
7retinoblastoma30.7CDKN2A, ERBB2, CDK4, CDKN2B, MAPK1, MTOR
8synovial sarcoma30.6KIT, FLI1
9gastrointestinal stromal tumor30.6KITLG, KIT
10lymphoblastic lymphoma30.5CDKN2B, FLI1
11neurofibroma30.4KITLG, KIT
12neurofibromatosis30.4KIT, KITLG
13peripheral primitive neuroectodermal tumor30.4FLI1, EWSR1
14leukemia30.3CSF3, KITLG, CDK4, CDKN2B, CDKN2A, KIT
15myelodysplastic syndromes30.3CSF3, KITLG, FAS, CDKN2B, KIT
16sarcoma30.2EWSR1, FLI1, MTOR, CDK4, KITLG, KIT
17malignant glioma30.2CDK4, CDKN2A, MAPK1, MTOR, FAS, CDKN2B
18myeloid leukemia30.1CSF3, CDKN2B, CDK4, KITLG, KIT, FAS
19melanoma29.9FAS, CDK4, EWSR1, KITLG, KIT, MAPK1
20supratentorial primitive neuroectodermal tumor11.1
21extraosseous ewing's sarcoma11.1
22askin's tumor10.9
23cerebritis10.8
24rhabdoid tumor10.8
25teratoma10.7
26atypical teratoid rhabdoid tumor10.6
27cervicitis10.6
28pineoblastoma10.6
29germ cell tumors10.6
30neuronitis10.5
31intracranial primitive neuroectodermal tumor10.5
32childhood medulloblastoma10.5
33prostatitis10.5
34thyroiditis10.5
35localized peripheral primitive neuroectodermal tumor10.5
36ependymoma10.5
37supratentorial primitive neuroectodermal tumors, childhood10.5
38ganglioglioma10.4
39cauda equina syndrome10.4
40trilateral retinoblastoma10.4
41unilateral retinoblastoma10.4
42cystic teratoma10.4
43mediastinitis10.4
44paraplegia10.4
45nonseminomatous germ cell tumor10.4
46pineoblastoma, childhood10.4
47extraskeletal ewing sarcoma10.4
48primitive neuroectodermal tumor10.3
49desmoplastic small round cell tumor10.3
50perinephritis10.3

Graphical network of the top 20 diseases related to Ewing's Family of Tumors:



Diseases related to ewing's family of tumors

Symptoms for Ewing's Family of Tumors

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Drugs & Therapeutics for Ewing's Family of Tumors

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Ewing's Family of Tumors

Genetic Tests for Ewing's Family of Tumors

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Anatomical Context for Ewing's Family of Tumors

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33MalaCards
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MalaCards organs/tissues related to Ewing's Family of Tumors:

33
Bone

Animal Models for Ewing's Family of Tumors or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Ewing's Family of Tumors:

37 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9FAS, KIT, KITLG, CDKN2A
2MP:00053718.9ERBB2, KITLG, KIT, FAS
3MP:00053918.4FAS, KIT, KITLG, CDKN2A, CDK4
4MP:00053818.3FAS, KIT, KITLG, ERBB2, CDKN2A, CDK4
5MP:00053678.1EWSR1, FAS, MTOR, CSF3, KIT, CDK4
6MP:00053908.0EWSR1, FAS, MTOR, KIT, KITLG, ERBB2
7MP:00053887.9FAS, MTOR, MAPK1, KIT, ERBB2, CDKN2A
8MP:00053797.9EWSR1, FAS, KIT, KITLG, ERBB2, CDKN2A
9MP:00053707.5FLI1, FAS, MAPK1, KIT, KITLG, CDKN2A
10MP:00053867.4FAS, MTOR, MAPK1, KIT, ERBB2, CDKN2A
11MP:00053897.3EWSR1, FAS, MAPK1, KIT, KITLG, ERBB2
12MP:00053857.2FLI1, FAS, MAPK1, KIT, KITLG, ERBB2
13MP:00053697.1EWSR1, FLI1, MTOR, MAPK1, KIT, ERBB2
14MP:00053807.0FLI1, MTOR, MAPK1, KIT, KITLG, ERBB2
15MP:00053767.0FAS, MTOR, MAPK1, KIT, KITLG, ERBB2
16MP:00107716.8EWSR1, FAS, MAPK1, CSF3, KIT, KITLG
17MP:00036316.5FLI1, FAS, MTOR, MAPK1, KIT, KITLG
18MP:00020066.5CDKN2B, EWSR1, FLI1, FAS, MAPK1, KIT
19MP:00053786.3EWSR1, FLI1, FAS, MTOR, MAPK1, KIT
20MP:00053976.1MTOR, FAS, FLI1, EWSR1, MAPK1, CSF3
21MP:00053876.1MTOR, FAS, FLI1, EWSR1, MAPK1, CSF3
22MP:00053846.1MTOR, FAS, FLI1, EWSR1, MAPK1, KIT
23MP:00107686.1MTOR, FAS, FLI1, EWSR1, MAPK1, KIT

Publications for Ewing's Family of Tumors

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52PubMed
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Articles related to Ewing's Family of Tumors:

(show all 13)
idTitleAuthorsYear
1
High-dose chemotherapy and stem cell rescue for high-risk Ewing's family of tumors. (21342043)
2011
2
Ewing's family of tumors of the sinonasal tract and maxillary bone. (21107767)
2011
3
Immunophenotypic profile of biomarkers related to anti-apoptotic and neural development pathways in the Ewing's family of tumors (EFT) and their therapeutic implications. (17695539)
2007
4
Prognostic and therapeutic targets in the Ewing's family of tumors (PROTHETS). (17163151)
2006
5
Single center experience of treatment of Ewing's family of tumors in Japan. (16437346)
2006
6
High-dose therapy and stem-cell rescue for Ewing's family of tumors in second remission. (15781877)
2005
7
EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. (15930281)
2005
8
Megatherapy and stem cell transplantation for Ewing's family of tumors: a critical review of current literature. (15125709)
2004
9
Single center experience of a new intensive induction therapy for ewing's family of tumors: feasibility, toxicity, and stem cell mobilization properties. (12885818)
2003
10
Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults. (12972518)
2003
11
Ewing's family of tumors involving structures related to the central nervous system: a review. (10742406)
2000
12
Chemotherapy dose-intensification for pediatric patients with Ewing's family of tumors and desmoplastic small round-cell tumors: a feasibility study at St. Jude Children's Research Hospital. (10458232)
1999
13
Ewing's family of tumors in adults: multivariate analysis of survival and long-term results of multimodality therapy in 182 patients. (9850016)
1998

Variations for Ewing's Family of Tumors

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Expression for genes affiliated with Ewing's Family of Tumors

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Ewing's Family of Tumors

Search GEO for disease gene expression data for Ewing's Family of Tumors.

Pathways for genes affiliated with Ewing's Family of Tumors

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50PathCards, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 5Cell Signaling Technology, 30KEGG, 54R&D Systems, 51PharmGKB, 57SinoBiological
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Pathways related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.4CDKN2B, CDK4, CDKN2A
2
Show member pathways
9.4CDK4, CDKN2B, CDKN2A
3
Show member pathways
9.4CDK4, CDKN2A, CDKN2B
49.3ERBB2, KITLG, KIT
59.3CSF3, KITLG, KIT
6
Show member pathways
DNA damage response38
9.3CDKN2A, FAS, CDK4
79.3CDK4, ERBB2, MTOR
89.2KIT, MAPK1, KITLG
9
Show member pathways
9.2KIT, MAPK1, KITLG
10
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)38
9.2KITLG, KIT, MAPK1
11
Show member pathways
Cell cycle38
9.2KITLG, CDKN2B, CDKN2A, CDK4
129.2MAPK1, MTOR, CDK4
13
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.2MTOR, CDK4, MAPK1
149.2MTOR, CDK4, MAPK1
15
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.2CDK4, MAPK1, MTOR
169.1CDK4, CDKN2A, MAPK1
179.1MTOR, MAPK1, CDKN2A
189.0CDKN2B, ERBB2, MAPK1
199.0ERBB2, MAPK1, MTOR
20
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.0MAPK1, ERBB2, MTOR
21
Show member pathways
Prolactin Signaling Pathway38
Development Prolactin receptor signaling60
Leptin signaling pathway38
9.0MAPK1, ERBB2, MTOR
229.0ERBB2, MAPK1, MTOR
23
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.0MTOR, ERBB2, MAPK1
24
Show member pathways
9.0ERBB2, KITLG, KIT, MTOR
25
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
8.9CDKN2A, ERBB2, MAPK1
268.8CDKN2B, CDKN2A, MAPK1, CDK4
27
Show member pathways
8.8CDKN2A, MAPK1, CDKN2B, CDK4
288.8CDKN2B, CDK4, CDKN2A, MAPK1
29
Show member pathways
8.8MAPK1, CDK4, CDKN2A, CDKN2B
30
Show member pathways
8.7KITLG, MAPK1, KIT, ERBB2
31
Show member pathways
8.7ERBB2, MAPK1, KIT, KITLG
32
Show member pathways
8.7KITLG, KIT, MAPK1, ERBB2
33
Show member pathways
Signal transduction PTEN pathway60
8.6MAPK1, MTOR, ERBB2, KIT
34
Show member pathways
8.6CDKN2A, ERBB2, MAPK1, CDK4
358.6KITLG, KIT, FAS, FLI1
368.5MTOR, MAPK1, ERBB2, CDKN2A
378.5FAS, MAPK1, ERBB2, MTOR
38
Show member pathways
8.3ERBB2, KITLG, MAPK1, MTOR, KIT
39
Show member pathways
8.3KITLG, KIT, MAPK1, MTOR, ERBB2
40
Show member pathways
8.3MAPK1, KITLG, ERBB2, KIT, CDKN2A
418.3CDKN2B, FAS, MAPK1, ERBB2, CDK4
42
Show member pathways
8.2MAPK1, CSF3, KIT, ERBB2, KITLG
438.0KIT, CDKN2B, ERBB2, MTOR, MAPK1, KITLG
44
Show member pathways
8.0CDKN2B, MAPK1, MTOR, KIT, ERBB2, KITLG
458.0MTOR, CDK4, KIT, CSF3, MAPK1, KITLG
46
Show member pathways
Signaling Pathways in Glioblastoma38
7.9MTOR, MAPK1, ERBB2, CDKN2A, CDK4, CDKN2B
47
Show member pathways
7.7FAS, ERBB2, KITLG, KIT, CSF3, MAPK1
48
Show member pathways
7.7MAPK1, KIT, KITLG, ERBB2, CDK4, CDKN2B
49
Show member pathways
7.1KITLG, MAPK1, CSF3, KIT, CDK4, CDKN2B
506.8CDK4, KIT, MAPK1, MTOR, FAS, KITLG

Compounds for genes affiliated with Ewing's Family of Tumors

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 3BitterDB
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Compounds related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1ag-1296459.5KIT, MAPK1, KITLG
2flavopiridol45 1110.2CDKN2A, KIT, ERBB2, CDK4
3daunorubicin45 51 1111.1FAS, CSF3, KITLG, CDKN2A
4hydroxyurea45 51 1111.1CSF3, CDKN2A, KITLG, KIT
5carboplatin45 51 1111.1CSF3, ERBB2, KITLG, CDK4
6gp 130459.0KIT, FAS, CSF3, KITLG
7erlotinib45 51 1111.0MTOR, MAPK1, KIT, ERBB2
8irinotecan45 51 1111.0ERBB2, KIT, CDKN2A, CSF3
9everolimus45 51 1110.9KIT, MTOR, ERBB2
10geldanamycin45 51 61 1111.9MAPK1, KIT, CDK4, ERBB2
11sp 60012545 619.8CDK4, FAS, MTOR, MAPK1
12agar458.8CDK4, CDKN2A, ERBB2, FAS, KITLG
13thymidylate458.8FAS, ERBB2, CDK4, CDKN2A
14valine458.7CDK4, CDKN2A, ERBB2, KIT, CSF3
15gefitinib45 51 1110.7MAPK1, ERBB2, CDK4, MTOR, KIT
16docetaxel45 51 61 1111.7CDKN2A, MTOR, CSF3, KIT, ERBB2
17butyrate458.7CDKN2A, FAS, CDK4, MAPK1, KITLG
18arsenite45 249.7CDKN2B, MTOR, MAPK1, CDKN2A, FAS
19herbimycin a45 619.6FAS, MAPK1, KITLG, ERBB2, CDK4
20trastuzumab45 51 1110.6KIT, FAS, MAPK1, CDK4, ERBB2
21cytarabine45 51 1110.6FAS, KITLG, KIT, CDKN2A, CDKN2B, CSF3
22resveratrol45 61 24 1111.6CDK4, ERBB2, MAPK1, MTOR, FAS
23egcg458.5MAPK1, FAS, ERBB2, CDKN2A, CDK4
24methotrexate51 45 1110.5CDKN2A, CDKN2B, KITLG, ERBB2, KIT, CSF3
25steroid458.5KIT, MTOR, ERBB2, CDKN2A, CDK4, KITLG
26n acetylcysteine458.4CDK4, CDKN2A, ERBB2, FAS, MAPK1
27actinomycin d458.4CDKN2A, MAPK1, KIT, KITLG, FAS
28wortmannin458.3FAS, ERBB2, KITLG, MAPK1, MTOR
29paraffin458.3KIT, FAS, CDK4, EWSR1, KITLG, ERBB2
30ly294002458.3MAPK1, KITLG, ERBB2, CDK4, FAS, MTOR
31thymidine45 249.3FAS, MAPK1, CSF3, KIT, KITLG, CDK4
32imatinib45 51 1110.2CSF3, KITLG, MTOR, MAPK1, ERBB2, KIT
33pd 98,059458.2MAPK1, KITLG, FAS, CDK4, KIT, MTOR
34testosterone45 61 24 1111.2MTOR, KIT, CDK4, KITLG, ERBB2, CDKN2A
35oligonucleotide458.1FAS, KIT, CDKN2A, CDK4, EWSR1, FLI1
36arginine458.0ERBB2, EWSR1, CDK4, CDKN2A, FAS, MTOR
37rapamycin458.0FAS, CDK4, KITLG, KIT, MAPK1, MTOR
38phosphatidylinositol457.9FAS, MAPK1, KIT, ERBB2, CDK4, MTOR
39genistein45 29 61 3 24 1112.9CDKN2A, ERBB2, FAS, KITLG, MAPK1, MTOR
405fluorouracil457.7KIT, CDK4, CDKN2A, KITLG, FAS, MTOR
41estrogen457.7MTOR, CDKN2A, MAPK1, CDKN2B, ERBB2, CDK4
42doxorubicin45 51 119.7ERBB2, CDK4, KITLG, KIT, CSF3, MTOR
43paclitaxel45 51 119.4KIT, CSF3, MAPK1, KITLG, ERBB2, CDKN2A
44cycloheximide457.4KITLG, FAS, ERBB2, CDKN2A, CDK4, MAPK1
45cisplatin45 51 61 1110.4MAPK1, FAS, CSF3, MTOR, CDKN2A, KITLG
46dexamethasone45 51 29 1110.4CDK4, CDKN2A, ERBB2, KITLG, CSF3, FAS
47vegf457.1CDK4, FAS, CDKN2A, ERBB2, KITLG, KIT
48retinoic acid45 248.0CSF3, KIT, KITLG, CDKN2A, MAPK1, MTOR
49tyrosine456.9CSF3, CDKN2B, MAPK1, KIT, FAS, EWSR1
50serine456.2EWSR1, FAS, MTOR, MAPK1, KIT, KITLG

GO Terms for genes affiliated with Ewing's Family of Tumors

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16Gene Ontology
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Cellular components related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.0CDKN2B, CDK4, CDKN2A, MAPK1, MTOR, FAS
2cytoplasmGO:0057377.1KITLG, EWSR1, FAS, MTOR, MAPK1, ERBB2
3nucleusGO:0056346.5CDKN2B, EWSR1, CDK4, CDKN2A, ERBB2, MAPK1

Biological processes related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:03523410.1KITLG, KIT
2embryonic hemopoiesisGO:03516210.0KIT, KITLG
3somatic stem cell divisionGO:04810310.0CDKN2A, KIT
4negative regulation of phosphorylationGO:0423269.9CDKN2B, CDKN2A
5negative regulation of immature T cell proliferation in thymusGO:0330889.8CDKN2A, ERBB2
6positive regulation of transcription from RNA polymerase III promoterGO:0459459.8ERBB2, MTOR
7extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.7KITLG, FAS
8signal transduction by phosphorylationGO:0230149.7KIT, ERBB2
9spleen developmentGO:0485369.7CDKN2B, FAS
10positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.6MTOR, CSF3, KITLG
11regulation of protein stabilityGO:0316479.5CDKN2A, MAPK1
12protein autophosphorylationGO:0467779.4ERBB2, KIT, MTOR
13peptidyl-threonine phosphorylationGO:0181079.4MTOR, MAPK1
14response to toxic substanceGO:0096369.4CDK4, MAPK1, FAS
15positive regulation of actin filament polymerizationGO:0308389.3CSF3, MTOR
16phosphatidylinositol-mediated signalingGO:0480159.3ERBB2, KITLG, KIT, MTOR
17positive regulation of translationGO:0457279.0CDK4, ERBB2, MAPK1, MTOR
18positive regulation of cell proliferationGO:0082848.9MAPK1, CSF3, KIT, CDK4
19fibroblast growth factor receptor signaling pathwayGO:0085438.7MTOR, MAPK1, KIT, KITLG, ERBB2
20Fc-epsilon receptor signaling pathwayGO:0380958.7ERBB2, KITLG, KIT, MAPK1, MTOR
21epidermal growth factor receptor signaling pathwayGO:0071738.7MTOR, MAPK1, KIT, KITLG, ERBB2
22neurotrophin TRK receptor signaling pathwayGO:0480118.7MTOR, MAPK1, KIT, KITLG, ERBB2
23innate immune responseGO:0450878.6MTOR, MAPK1, KIT, KITLG, ERBB2
24signal transductionGO:0071657.9FAS, MTOR, MAPK1, KIT, KITLG, ERBB2

Molecular functions related to Ewing's Family of Tumors according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:0048619.7CDKN2A, CDKN2B
2receptor signaling protein tyrosine kinase activityGO:0047169.6KIT, ERBB2
3transmembrane receptor protein tyrosine kinase activityGO:0047149.6KIT, ERBB2
4ATP bindingGO:0055248.0KIT, MAPK1, ERBB2, CDK4, MTOR
5protein bindingGO:0055156.6KITLG, EWSR1, FAS, MTOR, MAPK1, KIT

Products for genes affiliated with Ewing's Family of Tumors

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  • Antibodies
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Sources for Ewing's Family of Tumors

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet