MCID: EWN002
MIFTS: 46

Ewing's Family of Tumors malady

Genetic diseases, Rare diseases, Neuronal diseases, Bone diseases, Cancer diseases categories

Aliases & Classifications for Ewing's Family of Tumors

About this section

Ewing's Family of Tumors, Aliases & Descriptions:

Name: Ewing's Family of Tumors 41
Primitive Neuroectodermal Tumor 41 11
Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor 60
Ewing Sarcoma/peripheral Primitive Neuroectodermal Tumor 60
Neuroectodermal Tumor, Primitive 60
Ewing’s Tumor of Bone 41
 
Extraosseous Ewing’s 41
Neuroectodermal Tumors 60
Ewing Family of Tumors 41
Askin’s Tumor 41
Ewings Sarcoma 60


Classifications:



Summaries for Ewing's Family of Tumors

About this section


MalaCards based summary: Ewing's Family of Tumors, also known as primitive neuroectodermal tumor, is related to medulloblastoma and rhabdomyosarcoma. An important gene associated with Ewing's Family of Tumors is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are E2F mediated regulation of DNA replication and Cyclins and Cell Cycle Regulation. The drugs cyclophosphamide and etoposide and the compounds ag-1296 and flavopiridol have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Related Diseases for Ewing's Family of Tumors

About this section

Diseases related to Ewing's Family of Tumors via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1medulloblastoma31.6ERBB2, CDK4, CDKN2B
2rhabdomyosarcoma31.1FLI1, EWSR1, CDK4
3neuroectodermal tumor31.1EWSR1, FLI1
4embryonal rhabdomyosarcoma31.1EWSR1, CDK4
5peripheral primitive neuroectodermal tumor30.9FLI1, EWSR1
6lymphoblastic lymphoma30.9CDKN2B, FLI1
7neurofibroma30.8KITLG, KIT
8gastrointestinal stromal tumor30.8KITLG, KIT
9astrocytoma30.6MAPK1, CDK4, CDKN2A, CDKN2B
10ewing sarcoma30.6KITLG, MAPK1, EWSR1
11retinoblastoma30.1CDKN2A, ERBB2, CDK4, CDKN2B, MAPK1, MTOR
12sarcoma30.0EWSR1, FLI1, MTOR, CDK4, KITLG, KIT
13myelodysplastic syndrome30.0CSF3, KITLG, FAS, CDKN2B, KIT
14breast cancer29.9CDK4, MAPK1, FAS, ERBB2, MTOR
15malignant glioma29.7CDK4, CDKN2A, MAPK1, MTOR, FAS, CDKN2B
16myeloid leukemia29.4CSF3, CDKN2B, CDK4, KITLG, KIT, FAS
17glioblastoma29.3MAPK1, MTOR, KIT, ERBB2, CDKN2A, CDK4
18leukemia28.9CSF3, KITLG, CDK4, CDKN2B, CDKN2A, KIT
19melanoma28.9FAS, CDK4, EWSR1, KITLG, KIT, MAPK1
20supratentorial primitive neuroectodermal tumor11.1
21extraosseous ewing's sarcoma11.1
22askin's tumor10.9
23cerebral primitive neuroectodermal tumor10.9
24cerebritis10.9
25rhabdoid tumor10.8
26teratoma10.7
27atypical teratoid rhabdoid tumor10.6
28intracranial primitive neuroectodermal tumor10.6
29cervicitis10.6
30pineoblastoma10.6
31prostatitis10.6
32neuronitis10.6
33childhood medulloblastoma10.6
34thyroiditis10.6
35supratentorial primitive neuroectodermal tumors, childhood10.6
36adult acute lymphocytic leukemia10.5CDKN2B
37insulin-like growth factor i10.5
38cystic teratoma10.5
39ependymoma10.5
40connective tissue benign neoplasm10.4FLI1, EWSR1
41ganglioglioma10.4
42cauda equina syndrome10.4
43unilateral retinoblastoma10.4
44bone ewing's sarcoma10.4
45mediastinitis10.4
46paraplegia10.4
47nonseminomatous germ cell tumor10.4
48pineoblastoma, childhood10.4
49extraskeletal ewing sarcoma10.4
50myoepithelioma10.4EWSR1, KITLG

Graphical network of the top 20 diseases related to Ewing's Family of Tumors:



Diseases related to ewing's family of tumors

Symptoms for Ewing's Family of Tumors

About this section

Drugs & Therapeutics for Ewing's Family of Tumors

About this section

Drug clinical trials:

Search ClinicalTrials for Ewing's Family of Tumors

Search NIH Clinical Center for Ewing's Family of Tumors

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Ewing's Family of Tumors

About this section

Anatomical Context for Ewing's Family of Tumors

About this section

MalaCards organs/tissues related to Ewing's Family of Tumors:

31
Bone

Animal Models for Ewing's Family of Tumors or affiliated genes

About this section

MGI Mouse Phenotypes related to Ewing's Family of Tumors:

35 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9FAS, KIT, KITLG, CDKN2A
2MP:00053718.9ERBB2, KITLG, KIT, FAS
3MP:00053918.4FAS, KIT, KITLG, CDKN2A, CDK4
4MP:00053818.3FAS, KIT, KITLG, ERBB2, CDKN2A, CDK4
5MP:00053678.1EWSR1, FAS, MTOR, CSF3, KIT, CDK4
6MP:00053908.0EWSR1, FAS, MTOR, KIT, KITLG, ERBB2
7MP:00053887.9FAS, MTOR, MAPK1, KIT, ERBB2, CDKN2A
8MP:00053797.9EWSR1, FAS, KIT, KITLG, ERBB2, CDKN2A
9MP:00053707.5FLI1, FAS, MAPK1, KIT, KITLG, CDKN2A
10MP:00053867.4FAS, MTOR, MAPK1, KIT, ERBB2, CDKN2A
11MP:00053897.3EWSR1, FAS, MAPK1, KIT, KITLG, ERBB2
12MP:00053857.2FLI1, FAS, MAPK1, KIT, KITLG, ERBB2
13MP:00053697.1EWSR1, FLI1, MTOR, MAPK1, KIT, ERBB2
14MP:00053807.0FLI1, MTOR, MAPK1, KIT, KITLG, ERBB2
15MP:00053767.0FAS, MTOR, MAPK1, KIT, KITLG, ERBB2
16MP:00107716.8EWSR1, FAS, MAPK1, CSF3, KIT, KITLG
17MP:00036316.5FLI1, FAS, MTOR, MAPK1, KIT, KITLG
18MP:00020066.5CDKN2B, EWSR1, FLI1, FAS, MAPK1, KIT
19MP:00053786.3EWSR1, FLI1, FAS, MTOR, MAPK1, KIT
20MP:00053976.1MTOR, FAS, FLI1, EWSR1, MAPK1, CSF3
21MP:00053876.1MTOR, FAS, FLI1, EWSR1, MAPK1, CSF3
22MP:00053846.1MTOR, FAS, FLI1, EWSR1, MAPK1, KIT
23MP:00107686.1MTOR, FAS, FLI1, EWSR1, MAPK1, KIT

Publications for Ewing's Family of Tumors

About this section

Articles related to Ewing's Family of Tumors:

(show all 13)
idTitleAuthorsYear
1
High-dose chemotherapy and stem cell rescue for high-risk Ewing's family of tumors. (21342043)
2011
2
Ewing's family of tumors of the sinonasal tract and maxillary bone. (21107767)
2011
3
Immunophenotypic profile of biomarkers related to anti-apoptotic and neural development pathways in the Ewing's family of tumors (EFT) and their therapeutic implications. (17695539)
2007
4
Prognostic and therapeutic targets in the Ewing's family of tumors (PROTHETS). (17163151)
2006
5
Single center experience of treatment of Ewing's family of tumors in Japan. (16437346)
2006
6
High-dose therapy and stem-cell rescue for Ewing's family of tumors in second remission. (15781877)
2005
7
EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. (15930281)
2005
8
Megatherapy and stem cell transplantation for Ewing's family of tumors: a critical review of current literature. (15125709)
2004
9
Single center experience of a new intensive induction therapy for ewing's family of tumors: feasibility, toxicity, and stem cell mobilization properties. (12885818)
2003
10
Long-term event-free survival after intensive chemotherapy for Ewing's family of tumors in children and young adults. (12972518)
2003
11
Ewing's family of tumors involving structures related to the central nervous system: a review. (10742406)
2000
12
Chemotherapy dose-intensification for pediatric patients with Ewing's family of tumors and desmoplastic small round-cell tumors: a feasibility study at St. Jude Children's Research Hospital. (10458232)
1999
13
Ewing's family of tumors in adults: multivariate analysis of survival and long-term results of multimodality therapy in 182 patients. (9850016)
1998

Variations for Ewing's Family of Tumors

About this section

Expression for genes affiliated with Ewing's Family of Tumors

About this section
Search GEO for disease gene expression data for Ewing's Family of Tumors.

Pathways for genes affiliated with Ewing's Family of Tumors

About this section

Pathways related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4CDKN2A, CDK4, CDKN2B
2
Show member pathways
9.4CDKN2B, CDK4, CDKN2A
3
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation58
9.4CDKN2B, CDK4, CDKN2A
49.3ERBB2, KITLG, KIT
59.3KITLG, KIT, CSF3
6
Show member pathways
DNA damage response36
9.3FAS, CDKN2A, CDK4
79.3MTOR, ERBB2, CDK4
8
Show member pathways
Signaling events mediated by Stem cell factor receptor (c-Kit)36
9.2MAPK1, KIT, KITLG
9
Show member pathways
9.2MAPK1, KIT, KITLG
109.2KITLG, KIT, MAPK1
11
Show member pathways
Cell cycle36
9.2CDKN2B, CDK4, CDKN2A, KITLG
12
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
9.2CDK4, MAPK1, MTOR
139.2MTOR, MAPK1, CDK4
149.2MTOR, MAPK1, CDK4
15
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.2CDK4, MAPK1, MTOR
169.1CDK4, CDKN2A, MAPK1
179.1MTOR, MAPK1, CDKN2A
189.0MAPK1, ERBB2, CDKN2B
199.0ERBB2, MAPK1, MTOR
20
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.0MTOR, MAPK1, ERBB2
21
Show member pathways
Prolactin Signaling Pathway36
Development Prolactin receptor signaling58
Leptin signaling pathway36
9.0MTOR, MAPK1, ERBB2
229.0ERBB2, MAPK1, MTOR
23
Show member pathways
Translation Non genomic rapid action of Androgen Receptor58
9.0MTOR, MAPK1, ERBB2
24
Show member pathways
9.0ERBB2, KITLG, KIT, MTOR
25
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
8.9MAPK1, ERBB2, CDKN2A
26
Show member pathways
8.8CDKN2B, CDK4, CDKN2A, MAPK1
278.8MAPK1, CDKN2A, CDK4, CDKN2B
28
Show member pathways
8.8MAPK1, CDKN2A, CDK4, CDKN2B
298.8MAPK1, CDKN2A, CDK4, CDKN2B
30
Show member pathways
8.7ERBB2, KITLG, KIT, MAPK1
31
Show member pathways
8.7MAPK1, KIT, KITLG, ERBB2
32
Show member pathways
8.7MAPK1, KIT, KITLG, ERBB2
33
Show member pathways
Signal transduction PTEN pathway58
8.6MTOR, MAPK1, KIT, ERBB2
34
Show member pathways
8.6MAPK1, ERBB2, CDKN2A, CDK4
358.6FLI1, FAS, KIT, KITLG
368.5CDKN2A, ERBB2, MAPK1, MTOR
378.5FAS, MTOR, MAPK1, ERBB2
38
Show member pathways
8.3ERBB2, KITLG, KIT, MAPK1, MTOR
39
Show member pathways
8.3MTOR, MAPK1, KIT, KITLG, ERBB2
40
Show member pathways
8.3MAPK1, KIT, KITLG, ERBB2, CDKN2A
418.3FAS, MAPK1, ERBB2, CDK4, CDKN2B
42
Show member pathways
8.2MAPK1, CSF3, KIT, KITLG, ERBB2
43
Show member pathways
8.0MTOR, MAPK1, KIT, KITLG, ERBB2, CDKN2B
448.0MTOR, MAPK1, KIT, KITLG, ERBB2, CDKN2B
458.0MTOR, MAPK1, CSF3, KIT, KITLG, CDK4
46
Show member pathways
Signaling Pathways in Glioblastoma36
7.9MTOR, MAPK1, ERBB2, CDKN2A, CDK4, CDKN2B
47
Show member pathways
7.7FAS, MAPK1, CSF3, KIT, KITLG, ERBB2
48
Show member pathways
7.7MAPK1, KIT, KITLG, ERBB2, CDKN2A, CDK4
49
Show member pathways
7.1MAPK1, CSF3, KIT, KITLG, ERBB2, CDKN2A
506.8CDKN2B, FAS, MTOR, MAPK1, KIT, KITLG

Compounds for genes affiliated with Ewing's Family of Tumors

About this section

Compounds related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1ag-1296439.5KIT, MAPK1, KITLG
2flavopiridol43 1210.2CDKN2A, KIT, ERBB2, CDK4
3daunorubicin43 49 1211.1FAS, CSF3, KITLG, CDKN2A
4hydroxyurea43 49 1211.1CSF3, CDKN2A, KITLG, KIT
5carboplatin43 49 1211.1CSF3, ERBB2, KITLG, CDK4
6gp 130439.0KIT, FAS, CSF3, KITLG
7erlotinib43 49 1211.0MTOR, MAPK1, KIT, ERBB2
8irinotecan43 49 1211.0ERBB2, KIT, CDKN2A, CSF3
9everolimus43 49 1210.9KIT, MTOR, ERBB2
10geldanamycin43 49 59 1211.9MAPK1, KIT, CDK4, ERBB2
11sp 60012543 599.8CDK4, FAS, MTOR, MAPK1
12agar438.8CDK4, CDKN2A, ERBB2, FAS, KITLG
13thymidylate438.8FAS, ERBB2, CDK4, CDKN2A
14valine438.7CDK4, CDKN2A, ERBB2, KIT, CSF3
15gefitinib43 49 1210.7MAPK1, ERBB2, CDK4, MTOR, KIT
16docetaxel43 49 59 1211.7CDKN2A, MTOR, CSF3, KIT, ERBB2
17butyrate438.7CDKN2A, FAS, CDK4, MAPK1, KITLG
18arsenite43 249.7CDKN2B, MTOR, MAPK1, CDKN2A, FAS
19herbimycin a43 599.6FAS, MAPK1, KITLG, ERBB2, CDK4
20trastuzumab43 49 1210.6KIT, FAS, MAPK1, CDK4, ERBB2
21cytarabine43 49 1210.6FAS, KITLG, KIT, CDKN2A, CDKN2B, CSF3
22resveratrol43 59 24 1211.6CDK4, ERBB2, MAPK1, MTOR, FAS
23egcg438.5MAPK1, FAS, ERBB2, CDKN2A, CDK4
24methotrexate49 43 1210.5CDKN2A, CDKN2B, KITLG, ERBB2, KIT, CSF3
25steroid438.5KIT, MTOR, ERBB2, CDKN2A, CDK4, KITLG
26n acetylcysteine438.4CDK4, CDKN2A, ERBB2, FAS, MAPK1
27actinomycin d438.4CDKN2A, MAPK1, KIT, KITLG, FAS
28wortmannin438.3FAS, ERBB2, KITLG, MAPK1, MTOR
29paraffin438.3KIT, FAS, CDK4, EWSR1, KITLG, ERBB2
30ly294002438.3MAPK1, KITLG, ERBB2, CDK4, FAS, MTOR
31thymidine43 249.3FAS, MAPK1, CSF3, KIT, KITLG, CDK4
32imatinib43 49 1210.2CSF3, KITLG, MTOR, MAPK1, ERBB2, KIT
33pd 98,059438.2MAPK1, KITLG, FAS, CDK4, KIT, MTOR
34testosterone43 59 24 1211.2MTOR, KIT, CDK4, KITLG, ERBB2, CDKN2A
35oligonucleotide438.1FAS, KIT, CDKN2A, CDK4, EWSR1, FLI1
36arginine438.0ERBB2, EWSR1, CDK4, CDKN2A, FAS, MTOR
37rapamycin438.0FAS, CDK4, KITLG, KIT, MAPK1, MTOR
38phosphatidylinositol437.9FAS, MAPK1, KIT, ERBB2, CDK4, MTOR
39genistein43 28 59 2 24 1212.9CDKN2A, ERBB2, FAS, KITLG, MAPK1, MTOR
405fluorouracil437.7KIT, CDK4, CDKN2A, KITLG, FAS, MTOR
41estrogen437.7MTOR, CDKN2A, MAPK1, CDKN2B, ERBB2, CDK4
42doxorubicin43 49 129.7ERBB2, CDK4, KITLG, KIT, CSF3, MTOR
43paclitaxel43 49 129.4KIT, CSF3, MAPK1, KITLG, ERBB2, CDKN2A
44cycloheximide437.4KITLG, FAS, ERBB2, CDKN2A, CDK4, MAPK1
45cisplatin43 49 59 1210.4MAPK1, FAS, CSF3, MTOR, CDKN2A, KITLG
46dexamethasone43 49 28 1210.4CDK4, CDKN2A, ERBB2, KITLG, CSF3, FAS
47vegf437.1CDK4, FAS, CDKN2A, ERBB2, KITLG, KIT
48retinoic acid43 248.0CSF3, KIT, KITLG, CDKN2A, MAPK1, MTOR
49tyrosine436.9CSF3, CDKN2B, MAPK1, KIT, FAS, EWSR1
50serine436.2EWSR1, FAS, MTOR, MAPK1, KIT, KITLG

GO Terms for genes affiliated with Ewing's Family of Tumors

About this section

Cellular components related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058298.0MTOR, MAPK1, CDKN2A, CDK4, CDKN2B, FAS
2cytoplasmGO:00057377.1CDKN2B, EWSR1, FAS, MTOR, MAPK1, KITLG
3nucleusGO:00056346.5EWSR1, FLI1, FAS, MAPK1, ERBB2, CDKN2A

Biological processes related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1ectopic germ cell programmed cell deathGO:003523410.1KITLG, KIT
2embryonic hemopoiesisGO:003516210.0KIT, KITLG
3somatic stem cell divisionGO:004810310.0CDKN2A, KIT
4negative regulation of phosphorylationGO:00423269.9CDKN2B, CDKN2A
5negative regulation of immature T cell proliferation in thymusGO:00330889.8CDKN2A, ERBB2
6positive regulation of transcription from RNA polymerase III promoterGO:00459459.8ERBB2, MTOR
7extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.7KITLG, FAS
8signal transduction by phosphorylationGO:00230149.7KIT, ERBB2
9spleen developmentGO:00485369.7CDKN2B, FAS
10positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6MTOR, CSF3, KITLG
11regulation of protein stabilityGO:00316479.5CDKN2A, MAPK1
12protein autophosphorylationGO:00467779.4ERBB2, KIT, MTOR
13peptidyl-threonine phosphorylationGO:00181079.4MTOR, MAPK1
14response to toxic substanceGO:00096369.4CDK4, MAPK1, FAS
15positive regulation of actin filament polymerizationGO:00308389.3CSF3, MTOR
16phosphatidylinositol-mediated signalingGO:00480159.3ERBB2, KITLG, KIT, MTOR
17positive regulation of translationGO:00457279.0CDK4, ERBB2, MAPK1, MTOR
18positive regulation of cell proliferationGO:00082848.9MAPK1, CSF3, KIT, CDK4
19fibroblast growth factor receptor signaling pathwayGO:00085438.7MTOR, MAPK1, KIT, KITLG, ERBB2
20Fc-epsilon receptor signaling pathwayGO:00380958.7ERBB2, KITLG, KIT, MAPK1, MTOR
21epidermal growth factor receptor signaling pathwayGO:00071738.7MTOR, MAPK1, KIT, KITLG, ERBB2
22neurotrophin TRK receptor signaling pathwayGO:00480118.7MTOR, MAPK1, KIT, KITLG, ERBB2
23innate immune responseGO:00450878.6MTOR, MAPK1, KIT, KITLG, ERBB2
24signal transductionGO:00071657.9FAS, MTOR, MAPK1, KIT, KITLG, ERBB2

Molecular functions related to Ewing's Family of Tumors according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein serine/threonine kinase inhibitor activityGO:00048619.7CDKN2B, CDKN2A
2receptor signaling protein tyrosine kinase activityGO:00047169.6KIT, ERBB2
3transmembrane receptor protein tyrosine kinase activityGO:00047149.6ERBB2, KIT
4ATP bindingGO:00055248.0MTOR, MAPK1, KIT, ERBB2, CDK4
5protein bindingGO:00055156.6CDKN2B, EWSR1, FAS, MTOR, MAPK1, KIT

Products for genes affiliated with Ewing's Family of Tumors

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Ewing's Family of Tumors

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet