RASH
MCID: EXN002
MIFTS: 53

Exanthem (RASH) malady

Summaries for Exanthem

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 A rash is an area of irritated or swollen skin. many rashes are itchy, red, painful, and irritated. some rashes can also lead to blisters or patches of raw skin. rashes are a symptom of many different medical problems. other causes include irritating substances and allergies. certain genes can make people more likely to get rashes. contact dermatitis is a common type of rash. it causes redness, itching, and sometimes small bumps. you get the rash where you have touched an irritant, such as a chemical, or something you are allergic to, like poison ivy. some rashes develop right away. others form over several days. although most rashes clear up fairly quickly, others are long-lasting and need long-term treatment. because rashes can be caused by many different things, it's important to figure out what kind you have before you treat it. if it is a bad rash, if it does not go away, or if you have other symptoms, you should see your health care provider. treatments may include moisturizers, lotions, baths, cortisone creams that relieve swelling, and antihistamines, which relieve itching.

MalaCards: Exanthem, also known as exanthema, is related to eosinophilia and measles. An important gene associated with Exanthem is GOSR2 (golgi SNAP receptor complex member 2), and among its related pathways are glutamate degradation II and Tie2 Signaling. The compounds cycloheximide and amphotericin b have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and liver, and related mouse phenotypes are integument and tumorigenesis.

Wikipedia:63 An exanthem (from Greek ἐξάνθημα exanthema, \"a breaking out\") is a widespread rash usually... more...

Aliases & Classifications for Exanthem

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 33MedlinePlus, 34MeSH
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Aliases & Descriptions:

exanthem 8 10
exanthema 8 60
rashes 33
rash 8


External Ids:

Disease Ontology8 DOID:0050486
MeSH34 D005076

Related Diseases for Exanthem

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Exanthem family:

Bacterial Exanthem Viral Exanthem

Diseases related to Exanthem via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 517)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia30.9CD79A, IL5, CD4, CCL11, CCL27
2measles30.5CD4, CD79A
3lupus erythematosus30.4CD79A
4meningitis30.3CD79A, CD4, CRP
5infectious mononucleosis30.3CD4, CD79A
6encephalitis30.2CD4
7adult-onset still's disease30.1TNFRSF1B, CRP
8rubella30.1CD79A
9hepatitis30.1KRAS, CD4, GZMB, CCL27, CCL11
10systemic lupus erythematosus30.1TNFRSF1B, CRP, CD4, IL1RN, CD79A
11leukemia30.1HRAS, GZMB, NRAS, CCL11, CD4, CD79A
12pneumonia30.1CD79A, CCL11, CRP, TNFRSF1B, CD4, IL5
13purpura30.1CD79A
14toxic shock syndrome30.1CD4, IL1RN
15diarrhea30.1GOT1, CD79A, CD4, EGFR, CRP, GOT2
16dermatomyositis30.0IL1RN
17folliculitis30.0EGFR, CCL11
18mycosis fungoides30.0CCL27, GZMB, CD4, IL5
19hepatitis a30.0GOT1, GOT2
20acute leukemia30.0KRAS, HRAS
21lung cancer30.0EGFR, CD4, KRAS, HRAS, NRAS
22dermatitis30.0CCL11, NLRP3, TNFRSF1B, GZMB, IL5, CD79A
23arthritis30.0IL1RN, CD4, FTH1, FTL, CRP, TNFRSF1B
24pemphigus29.9CD79A
25muckle-wells syndrome29.9NLRP3
26uveitis29.9CD4, CCL11, TNFRSF1B
27neuropathy29.9CD4, CD79A
28neutropenia29.9TNFRSF1B, EGFR, IL1RN, GZMB
29encephalomyelitis29.8TNFRSF1B
30lichen planus29.8GZMB
31autoimmune lymphoproliferative syndrome29.8CD4
32leprosy29.8CD4
33cystic fibrosis29.8CD4
34conjunctivitis29.8CD79A, NLRP3
35mevalonic aciduria29.8IL1RN
36candidiasis29.8CD4, CD79A
37vaccinia29.8CD4
38crohn's disease29.8TNFRSF1B, CRP
39glomerulonephritis29.8CD79A, IL1RN
40allergic contact dermatitis29.8CCL27
41skin disease29.8CD79A, CCL27, IL5, CCL11
42herpes simplex29.8CD4, CD79A, TNFRSF1B
43acquired immunodeficiency syndrome29.8CD4
44urticaria29.8NLRP3, GZMB
45psoriasis29.8CD4, CCL11, CCL27, GZMB, TNFRSF1B, IL5
46brucellosis29.8CD79A
47vasculitis29.8TNFRSF1B, CRP, CD79A
48kawasaki disease29.8CRP
49mumps29.8CD79A, CD4
50arthropathy29.8IL1RN, NLRP3, TNFRSF1B, CRP

Graphical network of the top 20 diseases related to Exanthem:



Diseases related to exanthem

Clinical Features for Exanthem

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Drugs & Therapeutics for Exanthem

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Exanthem

Genetic Tests for Exanthem

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Anatomical Context for Exanthem

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32MalaCards
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MalaCards organs/tissues related to Exanthem:

32
Skin, T cells, Liver, Spinal cord, Brain, Breast, Myeloid, Prostate

Animal Models for Exanthem or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Exanthem:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.8NLRP3, TNFRSF1B, NRAS, CD4, HRAS, KRAS
2MP:00020068.7TNFRSF1B, HRAS, EGFR, NRAS, IL5, KRAS
3MP:00053708.5KRAS, IL5, FTH1, NRAS, TNFRSF1B, NLRP3
4MP:00053818.0KRAS, NLRP3, TNFRSF1B, CD4, EGFR, NRAS
5MP:00028737.9KRAS, HRAS, CD79A, CD4, NRAS, NLRP3
6MP:00053857.8KRAS, TNFRSF1B, HRAS, IL1RN, FTH1, NRAS
7MP:00053977.1NLRP3, CD4, CD79A, IL1RN, IL5, KRAS
8MP:00053876.6FTH1, IL5, IL1RN, CD79A, CD4, NRAS
9MP:00053766.5TNFRSF1B, HRAS, CRP, EGFR, IL5, NRAS

Publications for Exanthem

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50PubMed
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Articles related to Exanthem:

(show top 50)    (show all 225)
idTitleAuthorsYear
1
Acetaminophen-induced exanthem of the breasts. (22838093)
2012
2
Papular exanthem discloses acute myeloid leukaemia: interphase fluorescence in situ hybridization revealed deletion of p53 and gain at 8q22/8q24/Tel8q without trisomy 8. (19438543)
2010
3
Symmetrical drug-related intertriginous and flexural exanthem due to oral risperidone. (19419476)
2009
4
Maculopapular exanthem from propolis: case report and review of systemic cutaneous and non-cutaneous reactions. (20059499)
2009
5
An update on pityriasis rosea and other similar childhood exanthems. (19502983)
2009
6
Exanthem subitum-associated encephalitis: nationwide survey in Japan. (19818937)
2009
7
Cephalosporin induced toxic epidermal necrolysis and subsequent penicillin drug exanthem. (18566552)
2008
8
Generalized vasculitic exanthem following Loxosceles reclusa envenomation. (17518783)
2007
9
Violaceous exanthem as a manifestation of metastatic prostate cancer in skin. (16461102)
2006
10
Asymmetric periflexural exanthem of childhood in a child with axonal Guillain-BarrAc syndrome. (14996133)
2004
11
Asymmetric periflexural exanthem of childhood: who are you? (11730033)
2001
12
Quantitation of human herpesvirus 6 DNA in infant with exanthem subitum by microplate PCR-hybridization assay. (11472582)
2001
13
Hypoperfusion of right hemisphere on brain SPECT in a patient with exanthem subitum and left hemiparesis. (10921489)
2000
14
Detection of human herpesvirus 7 DNA in the cerebrospinal fluid of a child with exanthem subitum. (10703249)
2000
15
Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations. (10102435)
1999
16
Amoxycillin-induced flexural exanthem. (10233656)
1999
17
Erysipelas-like mercury exanthem. (9197976)
1997
18
Syndrome of inappropriate secretion of antidiuretic hormone associated with exanthem subitum. (9154555)
1997
19
Dermacase. Unilateral laterothoracic exanthem. (9266117)
1997
20
Erythematous exanthem associated with primary infection by human parvovirus B19. (7737770)
1995
21
Asymmetric periflexural exanthem of childhood and viral examinations. (7659637)
1995
22
The exanthem of HIV-1 seroconversion syndrome. (7790136)
1995
23
Asymmetric periflexural exanthem of childhood: report of two new cases. (8170849)
1994
24
Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). (8265302)
1994
25
Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications. (8388679)
1993
26
Unilateral laterothoracic exanthem. (8315075)
1993
27
Primary human herpesvirus-6 infection (exanthem subitum) in the newborn. (1329004)
1992
28
Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. (1315948)
1992
29
Severity of human herpesvirus-6 viremia and clinical findings in infants with exanthem subitum. (1645770)
1991
30
Transmission of chickenpox in a school setting prior to the observed exanthem. (2556025)
1989
31
Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals. (2550877)
1989
32
Identification of human herpesvirus-6 as a causal agent for exanthem subitum. (2896909)
1988
33
Immunophenotypic characterization of the cutaneous exanthem of SIV-infected rhesus monkeys. Apposition of degenerative Langerhans cells and cytotoxic lymphocytes during the development of acquired immunodeficiency syndrome. (3030113)
1987
34
Photodistribution of varicella exanthem: report of two cases. (3725698)
1986
35
Mercury exanthem. (3579765)
1986
36
Mercury exanthem. (6203944)
1984
37
Exanthem in northwestern Tasmania. (6843451)
1983
38
Exanthem subitum not associated with rotavirus. (6264296)
1981
39
Pathogenesis of the rubella exanthem: distribution of rubella virus in the skin during rubella with and without rash. (624853)
1978
40
Exanthem due to diphenylhydantoin therapy. (4245455)
1970
41
Measles encephalitis without exanthem. (5313058)
1970
42
An outbreak of type 26 Echovirus infection with exanthem in an infant home near Tokyo. (5654948)
1968
43
Echovirus type 18 infection: an unusual exanthem. (5939742)
1966
44
Vesicular exanthem and stomatitis. Report of an epidemic due to Coxsacke virus Group A, Type 16. (14492892)
1961
45
Common clinical syndromes of infectious disease. II. Common infectious exanthem. (13697544)
1960
46
Antigenic comparison of Boston exanthem virus strains and their relationship to ECHO-16 virus as studied by neutralization and complement fixation procedures. (14426738)
1959
47
Outbreak of aseptic meningitis with exanthem. (13499940)
1958
48
Clinical report of an unusual contagious exanthem. (13475664)
1957
49
Electron microscopic studies of the Roseola infantum (exanthem subitum) virus. (13281795)
1955
50
Exanthem Subitum-Report of Five Cases. (20314150)
1922

Genetic Variations for Exanthem

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Expression for genes affiliated with Exanthem

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Exanthem

Search GEO for disease gene expression data for Exanthem.

Pathways for genes affiliated with Exanthem

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 49PharmGKB, 55SinoBiological, 51QIAGEN, 59Tocris Bioscience, 12EMD Millipore
See all sources

Pathways related to Exanthem according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.7GOT1, GOT2
29.7NRAS, HRAS, KRAS
3
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9.7KRAS, HRAS, NRAS
49.7KRAS, HRAS, NRAS
59.7KRAS, HRAS, NRAS
69.7KRAS, HRAS, NRAS
7
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9.7NRAS, HRAS, KRAS
8
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9.7KRAS, HRAS, NRAS
99.7NRAS, HRAS, KRAS
10
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9.7KRAS, HRAS, NRAS
11
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9.7KRAS, HRAS, NRAS
129.6IL5, HRAS, KRAS
13
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9.6NRAS, CD79A, HRAS
14
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9.5EGFR, NRAS, HRAS
159.5EGFR, NRAS, HRAS
169.4CD4, NRAS, EGFR
17
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9.3KRAS, HRAS, CD79A, NRAS
18
Development Prolactin receptor signaling
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9.3NRAS, IL1RN, HRAS, KRAS
19
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9.2GZMB, TNFRSF1B, EGFR, NRAS
20
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9.2CCL11, GZMB, TNFRSF1B, CD4, IL5
21
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9.1EGFR, NRAS, HRAS, KRAS
22
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9.1KRAS, HRAS, NRAS, EGFR
239.1EGFR, NRAS, HRAS, KRAS
249.1EGFR, NRAS, HRAS, KRAS
25
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9.1KRAS, HRAS, NRAS, EGFR
26
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9.1EGFR, NRAS, HRAS, KRAS
27
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9.1EGFR, NRAS, HRAS, KRAS
28
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9.1EGFR, NRAS, HRAS, KRAS
299.1EGFR, NRAS, HRAS, KRAS
30
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9.1EGFR, NRAS, HRAS, KRAS
31
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9.1EGFR, NRAS, HRAS, KRAS
32
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9.1EGFR, NRAS, HRAS, KRAS
33
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9.1KRAS, HRAS, NRAS, EGFR
34
Development Endothelin-1/EDNRA signaling
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9.1EGFR, NRAS, HRAS, KRAS
35
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9.1KRAS, HRAS, NRAS, EGFR
36
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9.1TNFRSF1B, NRAS, CD4, IL5, HRAS
37
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9.1CD4, NRAS, EGFR, TNFRSF1B
38
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9.1CCL11, CCL27, CD4, IL5
39
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9.0NRAS, IL1RN, IL5, HRAS, KRAS
40
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9.0NRAS, IL1RN, IL5, HRAS, KRAS
41
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8.9EGFR, NRAS, IL5, HRAS, KRAS
42
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8.8CCL11, CCL27, NRAS, HRAS, KRAS
43
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8.8KRAS, HRAS, CD79A, NRAS, EGFR
44
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8.7NRAS, CD4, CD79A, IL5, HRAS, KRAS
45
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8.6KRAS, CCL11, GZMB, NRAS, CD79A, IL5
46
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8.6HRAS, NRAS, EGFR, CCL27, CCL11
47
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7.8NLRP3, EGFR, NRAS, CD4, CD79A, IL1RN
48
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7.8IL5, CD4, NRAS, EGFR, TNFRSF1B, CCL27
49
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7.8CCL11, HRAS, IL5, CD4, NRAS, EGFR
50
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7.8CCL11, CCL27, TNFRSF1B, EGFR, NRAS, CD4

Compounds for genes affiliated with Exanthem

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Exanthem according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.4CD4
2amphotericin b4410.4IL1RN
3rantes4410.2CD4, GZMB, CCL11
4endotoxin4410.1TNFRSF1B
5unicap4410.1CCL11, IL5, CD79A
6sodium cromoglycate4410.0IL5, CCL11, CD79A
7allergens449.8CCL27, CCL11, IL5
8con a449.8TNFRSF1B, CD79A, IL5
9salbutamol44 49 28 11 2413.8CCL11, IL5, CD79A
10anakinra44 1110.7NLRP3, CRP, IL1RN
11clarithromycin44 1110.7IL5, CCL11, CD79A, IL1RN
12methacholine44 1110.6IL5, CD79A, CCL11, CRP
13adalimumab44 49 1111.6CD79A, CRP, IL1RN
14L-Tyrosine11 2410.6GOT1, GOT2, EGFR
15tarc449.4CCL27, CCL11, CD4, IL5
16sulfasalazine44 28 49 1112.4IL1RN, CD79A, CRP
17hyaluronic acid44 2410.4CD79A, CCL11, IL1RN, GZMB
18polyethylene glycol449.3CRP, IL1RN, CD79A, TNFRSF1B
19herbimycin a44 5910.3HRAS, EGFR, IL5, CCL11, CD4
20p002449.3TNFRSF1B, KRAS, IL1RN, CRP
21oxygen44 2410.3TNFRSF1B, CCL11, KRAS, HRAS, FTL, FTH1
22heparin44 28 11 2412.3IL1RN, CD79A, CCL11, GZMB, CD4
23imatinib44 49 1111.3KRAS, GZMB, IL5, EGFR
24agar449.2NRAS, EGFR, IL5, HRAS, CD79A
25chloroquine44 2 49 28 1113.2CD79A, CD4, IL1RN, FTL, TNFRSF1B
26vitamin d449.1TNFRSF1B, CD79A, IL1RN, IL5, KRAS
27etanercept44 49 1111.0IL1RN, CRP, TNFRSF1B
28prednisolone44 28 1111.0IL5, CD79A, IL1RN, CCL11, CRP, GZMB
29rapamycin449.0KRAS, HRAS, EGFR, GZMB, CRP
30ivig449.0CD79A, TNFRSF1B, GZMB, CRP, IL1RN, IL5
31pge2449.0CD4, CCL11, HRAS, CCL27, EGFR
32dexamethasone44 49 28 1112.0CD79A, CCL11, IL5, CCL27, GZMB, TNFRSF1B
33sb 20358044 599.9EGFR, IL1RN, IL5, CCL11, CRP
34paraffin448.9KRAS, HRAS, CD79A, IL5, GZMB, EGFR
35cyclosporin a44 28 5910.9IL1RN, CCL11, GZMB, TNFRSF1B, CD79A, IL5
36genistein44 28 59 2 11 2413.9HRAS, IL5, CD4, EGFR, CCL11
37methotrexate44 49 1110.9CD79A, TNFRSF1B, CRP, NLRP3, IL5, IL1RN
38neopterin448.9TNFRSF1B, IL1RN, CD79A, CD4, CRP, GZMB
39oligonucleotide448.8CD4, TNFRSF1B, KRAS, HRAS, NRAS, GZMB
40cysteine448.6GZMB, IL1RN, CD4, TNFRSF1B, CD79A, HRAS
41h2o2448.5TNFRSF1B, HRAS, KRAS, CD79A, FTH1, FTL
42ly294002448.4GZMB, CCL11, TNFRSF1B, CRP, EGFR, HRAS
43testosterone44 59 11 2411.4CD79A, TNFRSF1B, IL5, CRP, EGFR, IL1RN
44estrogen448.4GZMB, EGFR, CD79A, IL1RN, HRAS, KRAS
45alanine448.2IL1RN, CCL11, CD79A, CD4, CRP, GZMB
46cholesterol44 28 11 2411.2CRP, TNFRSF1B, FTL, CD4, IL1RN, HRAS
47retinoic acid44 249.1CD79A, HRAS, IL5, IL1RN, TNFRSF1B, GZMB
48tyrosine447.9HRAS, CCL11, EGFR, TNFRSF1B, GZMB, KRAS
49vegf447.6CCL11, GZMB, TNFRSF1B, CRP, EGFR, CD79A
50lipid447.3HRAS, KRAS, FTH1, TNFRSF1B, CD4, CCL27

GO Terms for genes affiliated with Exanthem

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16Gene Ontology
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Cellular components related to Exanthem according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular ferritin complexGO:0080439.9FTL, FTH1
2membrane raftGO:0451218.6KRAS, CD79A, CD4, EGFR, TNFRSF1B
3extracellular spaceGO:0056157.7CCL11, CCL27, CRP, EGFR, IL1RN, IL5
4plasma membraneGO:0058866.8CRP, EGFR, NRAS, CD4, CD79A, IL1RN

Biological processes related to Exanthem according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1glutamate catabolic process to 2-oxoglutarateGO:01955110.1GOT2, GOT1
2glutamate catabolic process to aspartateGO:01955010.0GOT2, GOT1
3aspartate biosynthetic processGO:00653210.0GOT2, GOT1
4positive regulation of Rac protein signal transductionGO:03502210.0KRAS, HRAS, NRAS
5regulation of synaptic transmission, GABAergicGO:03222810.0NRAS, HRAS, KRAS
6striated muscle cell differentiationGO:05114610.0NRAS, HRAS, KRAS
7regulation of long-term neuronal synaptic plasticityGO:04816910.0KRAS, HRAS, NRAS
8aspartate metabolic processGO:00653110.0GOT1, GOT2
9aspartate catabolic processGO:00653310.0GOT1, GOT2
10visual learningGO:0085429.9NRAS, HRAS, KRAS
11oxaloacetate metabolic processGO:0061079.8GOT1, GOT2
12Ras protein signal transductionGO:0072659.8NRAS, HRAS, KRAS
13glutamate metabolic processGO:0065369.7GOT2, GOT1
14negative regulation of neuron apoptotic processGO:0435249.7KRAS, HRAS, NRAS
15response to glucocorticoid stimulusGO:0513849.7GOT1, KRAS, IL1RN
16positive regulation of MAP kinase activityGO:0434069.6EGFR, HRAS, KRAS
17activation of MAPKK activityGO:0001869.5KRAS, HRAS, NRAS, EGFR
18MAPK cascadeGO:0001659.5EGFR, NRAS, HRAS, KRAS
19fibroblast growth factor receptor signaling pathwayGO:0085439.4KRAS, HRAS, NRAS, EGFR
20Fc-epsilon receptor signaling pathwayGO:0380959.3EGFR, NRAS, HRAS, KRAS
21inflammatory responseGO:0069549.3CCL11, NLRP3, TNFRSF1B, CRP, IL5
22epidermal growth factor receptor signaling pathwayGO:0071739.3EGFR, NRAS, HRAS, KRAS
23positive regulation of protein phosphorylationGO:0019349.3KRAS, HRAS, EGFR
24neurotrophin TRK receptor signaling pathwayGO:0480118.8EGFR, NRAS, HRAS, KRAS
25innate immune responseGO:0450878.8NLRP3, EGFR, NRAS, CD4, HRAS, KRAS
26immune responseGO:0069558.5IL5, CCL11, CCL27, TNFRSF1B, FTH1, CD4

Molecular functions related to Exanthem according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:00819910.0FTH1, FTL
2L-aspartate:2-oxoglutarate aminotransferase activityGO:0040699.6GOT1, GOT2
3L-phenylalanine:2-oxoglutarate aminotransferase activityGO:0801309.4GOT1, GOT2

Products for genes affiliated with Exanthem

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Exanthem

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet