Exanthem disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Exanthem

Sources:
³³MedlinePlus, ⁶³Wikipedia, ³²MalaCards
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MedlinePlus:³³ A rash is an area of irritated or swollen skin. many rashes are itchy, red, painful, and irritated. some rashes can also lead to blisters or patches of raw skin. rashes are a symptom of many different medical problems. other causes include irritating substances and allergies. certain genes can make people more likely to get rashes. contact dermatitis is a common type of rash. it causes redness, itching, and sometimes small bumps. you get the rash where you have touched an irritant, such as a chemical, or something you are allergic to, like poison ivy. some rashes develop right away. others form over several days. although most rashes clear up fairly quickly, others are long-lasting and need long-term treatment. because rashes can be caused by many different things, it's important to figure out what kind you have before you treat it. if it is a bad rash, if it does not go away, or if you have other symptoms, you should see your health care provider. treatments may include moisturizers, lotions, baths, cortisone creams that relieve swelling, and antihistamines, which relieve itching.

MalaCards: Exanthem, also known as exanthema, is related to eosinophilia and measles. An important gene associated with Exanthem is GOSR2 (golgi SNAP receptor complex member 2), and among its related pathways are glutamate degradation II and Tie2 Signaling. The compounds cycloheximide and amphotericin b have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and liver, and related mouse phenotypes are integument and tumorigenesis.

Wikipedia:⁶³ An exanthem (from Greek ἐξάνθημα exanthema, \"a breaking out\") is a widespread rash usually... more...

Aliases & Classifications for Exanthem

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁶⁰UMLS, ³³MedlinePlus, ³⁴MeSH
See all sources

Aliases & Descriptions:

exanthem ⁸ ¹⁰

exanthema ⁸ ⁶⁰

rashes ³³

rash ⁸

External Ids:

Disease Ontology⁸ DOID:0050486

MeSH³⁴ D005076

Related Diseases for Exanthem

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Exanthem family:

Bacterial Exanthem	Viral Exanthem

Diseases related to Exanthem via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 517)

id	Related Disease	Score	Top Affiliating Genes
1	eosinophilia	30.9	CD79A, IL5, CD4, CCL11, CCL27
2	measles	30.5	CD4, CD79A
3	lupus erythematosus	30.4	CD79A
4	meningitis	30.3	CD79A, CD4, CRP
5	infectious mononucleosis	30.3	CD4, CD79A
6	encephalitis	30.2	CD4
7	adult-onset still's disease	30.1	TNFRSF1B, CRP
8	rubella	30.1	CD79A
9	hepatitis	30.1	KRAS, CD4, GZMB, CCL27, CCL11
10	systemic lupus erythematosus	30.1	TNFRSF1B, CRP, CD4, IL1RN, CD79A
11	leukemia	30.1	HRAS, GZMB, NRAS, CCL11, CD4, CD79A
12	pneumonia	30.1	CD79A, CCL11, CRP, TNFRSF1B, CD4, IL5
13	purpura	30.1	CD79A
14	toxic shock syndrome	30.1	CD4, IL1RN
15	diarrhea	30.1	GOT1, CD79A, CD4, EGFR, CRP, GOT2
16	dermatomyositis	30.0	IL1RN
17	folliculitis	30.0	EGFR, CCL11
18	mycosis fungoides	30.0	CCL27, GZMB, CD4, IL5
19	hepatitis a	30.0	GOT1, GOT2
20	acute leukemia	30.0	KRAS, HRAS
21	lung cancer	30.0	EGFR, CD4, KRAS, HRAS, NRAS
22	dermatitis	30.0	CCL11, NLRP3, TNFRSF1B, GZMB, IL5, CD79A
23	arthritis	30.0	IL1RN, CD4, FTH1, FTL, CRP, TNFRSF1B
24	pemphigus	29.9	CD79A
25	muckle-wells syndrome	29.9	NLRP3
26	uveitis	29.9	CD4, CCL11, TNFRSF1B
27	neuropathy	29.9	CD4, CD79A
28	neutropenia	29.9	TNFRSF1B, EGFR, IL1RN, GZMB
29	encephalomyelitis	29.8	TNFRSF1B
30	lichen planus	29.8	GZMB
31	autoimmune lymphoproliferative syndrome	29.8	CD4
32	leprosy	29.8	CD4
33	cystic fibrosis	29.8	CD4
34	conjunctivitis	29.8	CD79A, NLRP3
35	mevalonic aciduria	29.8	IL1RN
36	candidiasis	29.8	CD4, CD79A
37	vaccinia	29.8	CD4
38	crohn's disease	29.8	TNFRSF1B, CRP
39	glomerulonephritis	29.8	CD79A, IL1RN
40	allergic contact dermatitis	29.8	CCL27
41	skin disease	29.8	CD79A, CCL27, IL5, CCL11
42	herpes simplex	29.8	CD4, CD79A, TNFRSF1B
43	acquired immunodeficiency syndrome	29.8	CD4
44	urticaria	29.8	NLRP3, GZMB
45	psoriasis	29.8	CD4, CCL11, CCL27, GZMB, TNFRSF1B, IL5
46	brucellosis	29.8	CD79A
47	vasculitis	29.8	TNFRSF1B, CRP, CD79A
48	kawasaki disease	29.8	CRP
49	mumps	29.8	CD79A, CD4
50	arthropathy	29.8	IL1RN, NLRP3, TNFRSF1B, CRP

Graphical network of the top 20 diseases related to Exanthem:

Clinical Features for Exanthem

Drugs & Therapeutics for Exanthem

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
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Approved drugs:

Search CenterWatch for Exanthem

Drug clinical trials:

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Search NIH Clinical Center for Exanthem

Search CenterWatch for Exanthem

Genetic Tests for Exanthem

Anatomical Context for Exanthem

Sources:
³²MalaCards
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MalaCards organs/tissues related to Exanthem:

³²

Skin, T cells, Liver, Spinal cord, Brain, Breast, Myeloid, Prostate

Animal Models for Exanthem or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Exanthem:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument phenotype	MP:0010771	8.8	NLRP3, TNFRSF1B, NRAS, CD4, HRAS, KRAS
2	tumorigenesis	MP:0002006	8.7	TNFRSF1B, HRAS, EGFR, NRAS, IL5, KRAS
3	liver/biliary system phenotype	MP:0005370	8.5	KRAS, IL5, FTH1, NRAS, TNFRSF1B, NLRP3
4	digestive/alimentary phenotype	MP:0005381	8.0	KRAS, NLRP3, TNFRSF1B, CD4, EGFR, NRAS
5	normal phenotype	MP:0002873	7.9	KRAS, HRAS, CD79A, CD4, NRAS, NLRP3
6	cardiovascular system phenotype	MP:0005385	7.8	KRAS, TNFRSF1B, HRAS, IL1RN, FTH1, NRAS
7	hematopoietic system phenotype	MP:0005397	7.1	NLRP3, CD4, CD79A, IL1RN, IL5, KRAS
8	immune system phenotype	MP:0005387	6.6	FTH1, IL5, IL1RN, CD79A, CD4, NRAS
9	homeostasis/metabolism phenotype	MP:0005376	6.5	TNFRSF1B, HRAS, CRP, EGFR, IL5, NRAS

Publications for Exanthem

Sources:
⁵⁰PubMed
See all sources

Articles related to Exanthem:

(show top 50) (show all 225)

id	Title	Authors	Year
1	Acetaminophen-induced exanthem of the breasts. (22838093)	Arora R.... Maddox C.L.	2012
2	Papular exanthem discloses acute myeloid leukaemia: interphase fluorescence in situ hybridization revealed deletion of p53 and gain at 8q22/8q24/Tel8q without trisomy 8. (19438543)	Kaune K.M.... Emmert S.	2010
3	Symmetrical drug-related intertriginous and flexural exanthem due to oral risperidone. (19419476)	Akay B.N.... Sanli H.	2009
4	Maculopapular exanthem from propolis: case report and review of systemic cutaneous and non-cutaneous reactions. (20059499)	Komericki P.... KrAonke B.	2009
5	An update on pityriasis rosea and other similar childhood exanthems. (19502983)	Browning J.C.	2009
6	Exanthem subitum-associated encephalitis: nationwide survey in Japan. (19818937)	Yoshikawa T.... Asano Y.	2009
7	Cephalosporin induced toxic epidermal necrolysis and subsequent penicillin drug exanthem. (18566552)	Lam A.... Klaustermeyer W.	2008
8	Generalized vasculitic exanthem following Loxosceles reclusa envenomation. (17518783)	Robb C.W.... Boyd A.S.	2007
9	Violaceous exanthem as a manifestation of metastatic prostate cancer in skin. (16461102)	Slovin S.F.... Busam K.	2006
10	Asymmetric periflexural exanthem of childhood in a child with axonal Guillain-BarrAc syndrome. (14996133)	Auvin S.... Martinot A.	2004
11	Asymmetric periflexural exanthem of childhood: who are you? (11730033)	Gelmetti C.... Caputo R.	2001
12	Quantitation of human herpesvirus 6 DNA in infant with exanthem subitum by microplate PCR-hybridization assay. (11472582)	Abe T.... Asano Y.	2001
13	Hypoperfusion of right hemisphere on brain SPECT in a patient with exanthem subitum and left hemiparesis. (10921489)	Ohta H.... Nii M.	2000
14	Detection of human herpesvirus 7 DNA in the cerebrospinal fluid of a child with exanthem subitum. (10703249)	Komatsu H.... Kikuta H.	2000
15	Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations. (10102435)	van den Berg J.S.... Galama J.M.	1999
16	Amoxycillin-induced flexural exanthem. (10233656)	Wakelin S.H.... Shaw S.	1999
17	Erysipelas-like mercury exanthem. (9197976)	Descamps V.... Belaich S.	1997
18	Syndrome of inappropriate secretion of antidiuretic hormone associated with exanthem subitum. (9154555)	Okafuji T.... Maekawa K.	1997
19	Dermacase. Unilateral laterothoracic exanthem. (9266117)	Adams S.P.	1997
20	Erythematous exanthem associated with primary infection by human parvovirus B19. (7737770)	Veraldi S.... Rizzitelli G.	1995
21	Asymmetric periflexural exanthem of childhood and viral examinations. (7659637)	Harangi F.... SzA1cs G.	1995
22	The exanthem of HIV-1 seroconversion syndrome. (7790136)	Alessi E.... Cusini M.	1995
23	Asymmetric periflexural exanthem of childhood: report of two new cases. (8170849)	Gelmetti C.... Caputo R.	1994
24	Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). (8265302)	Asano Y.... Ozaki T.	1994
25	Clinical and virological analyses of 21 infants with exanthem subitum (roseola infantum) and central nervous system complications. (8388679)	Suga S.... Ozaki T.	1993
26	Unilateral laterothoracic exanthem. (8315075)	Melski J.W.	1993
27	Primary human herpesvirus-6 infection (exanthem subitum) in the newborn. (1329004)	Kawaguchi S.... Asano Y.	1992
28	Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. (1315948)	Yoshikawa T.... Yamanishi K.	1992
29	Severity of human herpesvirus-6 viremia and clinical findings in infants with exanthem subitum. (1645770)	Asano Y.... Yazaki T.	1991
30	Transmission of chickenpox in a school setting prior to the observed exanthem. (2556025)	Brunell P.A.	1989
31	Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals. (2550877)	Yoshikawa T.... Ozaki T.	1989
32	Identification of human herpesvirus-6 as a causal agent for exanthem subitum. (2896909)	Yamanishi K.... Kurata T.	1988
33	Immunophenotypic characterization of the cutaneous exanthem of SIV-infected rhesus monkeys. Apposition of degenerative Langerhans cells and cytotoxic lymphocytes during the development of acquired immunodeficiency syndrome. (3030113)	Ringler D.J.... Murphy G.F.	1987
34	Photodistribution of varicella exanthem: report of two cases. (3725698)	Serrano G.... Otero D.	1986
35	Mercury exanthem. (3579765)	Rogers M.... McColl I.	1986
36	Mercury exanthem. (6203944)	Nakayama H.... Hada S.	1984
37	Exanthem in northwestern Tasmania. (6843451)	Shugg A.W.	1983
38	Exanthem subitum not associated with rotavirus. (6264296)	Gurwith M.... Feltham S.	1981
39	Pathogenesis of the rubella exanthem: distribution of rubella virus in the skin during rubella with and without rash. (624853)	Heggie A.D.	1978
40	Exanthem due to diphenylhydantoin therapy. (4245455)	ROBINSON H.M.... Stone J.H.	1970
41	Measles encephalitis without exanthem. (5313058)	Yassin M.W.... el-Ela A.A.	1970
42	An outbreak of type 26 Echovirus infection with exanthem in an infant home near Tokyo. (5654948)	Moritsugu Y.... Futaki T.	1968
43	Echovirus type 18 infection: an unusual exanthem. (5939742)	Wedemeyer P.P.... St GEME J.W.	1966
44	Vesicular exanthem and stomatitis. Report of an epidemic due to Coxsacke virus Group A, Type 16. (14492892)	ROBINSON C.R.... RHODES A.J.	1961
45	Common clinical syndromes of infectious disease. II. Common infectious exanthem. (13697544)	Evans A.S.	1960
46	Antigenic comparison of Boston exanthem virus strains and their relationship to ECHO-16 virus as studied by neutralization and complement fixation procedures. (14426738)	Neva F.A.... Lewis L.J.	1959
47	Outbreak of aseptic meningitis with exanthem. (13499940)	GALPINE J.F.... BASTER N.	1958
48	Clinical report of an unusual contagious exanthem. (13475664)	TRYGSTAD E.H.	1957
49	Electron microscopic studies of the Roseola infantum (exanthem subitum) virus. (13281795)	REAGAN R.L.... BRUECKNER A.L.	1955
50	Exanthem Subitum-Report of Five Cases. (20314150)	Goldbloom A.	1922

Genes related to Exanthem

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Exanthem:

(show all 20)

id	Symbol	Description	Score	Implication
1	GOSR2	golgi SNAP receptor complex member 2	20.47	GeneCards inferred : Disorders (show sections)
2	FTH1	ferritin, heavy polypeptide 1	19.47	GeneCards inferred : Disorders (show sections)
3	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	18.47	GeneCards inferred : Publications, Disorders (show sections)
4	CCL11	chemokine (C-C motif) ligand 11	17.47	GeneCards inferred : Publications, Disorders (show sections)
5	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	16.47	GeneCards inferred : Disorders (show sections)
6	GOT1	glutamic-oxaloacetic transaminase 1, soluble	15.47	GeneCards inferred : Disorders (show sections)
7	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	14.47	GeneCards inferred : Publications, Disorders (show sections)
8	NLRP3	NLR family, pyrin domain containing 3	13.47	GeneCards inferred : Disorders (show sections)
9	HRAS	Harvey rat sarcoma viral oncogene homolog	12.47	GeneCards inferred : Disorders (show sections)
10	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.47	GeneCards inferred : Disorders (show sections)
11	FTL	ferritin, light polypeptide	10.47	GeneCards inferred : Disorders (show sections)
12	KRAS	Kirsten rat sarcoma viral oncogene homolog	9.47	GeneCards inferred : Disorders (show sections)
13	CD4	CD4 molecule	8.47	GeneCards inferred : Disorders (show sections)
14	CD79A	CD79a molecule, immunoglobulin-associated alpha	7.47	GeneCards inferred : Disorders (show sections)
15	IL1RN	interleukin 1 receptor antagonist	6.47	GeneCards inferred : Disorders (show sections)
16	CRP	C-reactive protein, pentraxin-related	5.47	GeneCards inferred : Disorders (show sections)
17	EGFR	epidermal growth factor receptor	4.47	GeneCards inferred : Disorders (show sections)
18	CCL27	chemokine (C-C motif) ligand 27	3.47	GeneCards inferred : Disorders (show sections)
19	PRPF18	pre-mRNA processing factor 18	2.47	GeneCards inferred : Disorders (show sections)
20	GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial	1.47	GeneCards inferred : Disorders (show sections)

Products for genes related to Exanthem disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	20	20	20
2	LSBio	-	-	20

Genetic Variations for Exanthem

Expression for genes affiliated with Exanthem

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Exanthem

Search GEO for disease gene expression data for Exanthem.

Pathways for genes affiliated with Exanthem

Sources:
³⁷NCBI BioSystems Database, ²⁹KEGG, ⁵³Reactome, ⁴⁹PharmGKB, ⁵⁵SinoBiological, ⁵¹QIAGEN, ⁵⁹Tocris Bioscience, ¹²EMD Millipore
See all sources

Pathways related to Exanthem according to GeneCards/GeneDecks:

(show top 50) (show all 63)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	glutamate degradation II³⁷ Hide members Phenylalanine, tyrosine and tryptophan biosynthesis²⁹ aspartate biosynthesis³⁷ aspartate degradation II³⁷	9.7	GOT1, GOT2
2	Tie2 Signaling⁵³	9.7	NRAS, HRAS, KRAS
3	Signalling to RAS⁵³ Hide members Signalling to ERKs⁵³ p38MAPK events⁵³	9.7	KRAS, HRAS, NRAS
4	Bisphosphonate Pathway, Pharmacodynamics⁴⁹	9.7	KRAS, HRAS, NRAS
5	Thyroid cancer²⁹	9.7	KRAS, HRAS, NRAS
6	NCAM signaling for neurite out-growth⁵³	9.7	KRAS, HRAS, NRAS
7	VEGF Signaling Pathway⁴⁹ Hide members VEGF Signaling⁵⁵	9.7	NRAS, HRAS, KRAS
8	Signaling by FGFR1 mutants⁵³ Hide members Signaling by FGFR mutants⁵³	9.7	KRAS, HRAS, NRAS
9	Long-term depression²⁹	9.7	NRAS, HRAS, KRAS
10	ARMS-mediated activation⁵³ Hide members Prolonged ERK activation events⁵³ Signalling to p38 via RIT and RIN⁵³ Frs2-mediated activation⁵³	9.7	KRAS, HRAS, NRAS
11	Glioma²⁹ Hide members Melanoma²⁹ Non-small cell lung cancer²⁹ Bladder cancer²⁹ Prostate cancer²⁹ Signaling Pathways in Glioblastoma³⁷	9.7	KRAS, HRAS, NRAS
12	IL-5 Signaling Pathway³⁷	9.6	IL5, HRAS, KRAS
13	Fc-GammaR Pathway⁵¹ Hide members Fc-Gamma-RIIB Signaling in B-Cells⁵¹	9.6	NRAS, CD79A, HRAS
14	Sorafenib Pharmacodynamics⁴⁹ Hide members VEGF Pathway⁵⁹ Vemurafenib Pathway, Pharmacodynamics⁴⁹	9.5	EGFR, NRAS, HRAS
15	Agrin Interactions at Neuromuscular Junction⁵¹	9.5	EGFR, NRAS, HRAS
16	G-protein signaling N-RAS regulation pathway¹²	9.4	CD4, NRAS, EGFR
17	FCERI mediated Ca+2 mobilization⁵³ Hide members FCERI mediated MAPK activation⁵³ Antigen Activates B Cell Receptor Leading to Generation of Second Messengers⁵³	9.3	KRAS, HRAS, CD79A, NRAS
18	Development Prolactin receptor signaling Hide members Prolactin signaling pathway²⁹ Prolactin Signaling Pathway³⁷ Development Prolactin receptor signaling¹² Leptin signaling pathway³⁷	9.3	NRAS, IL1RN, HRAS, KRAS
19	DREAM Repression and Dynorphin Expression⁵¹ Hide members Calpain Protease Regulates Cellular Mechanics⁵¹ Caspase Cascade⁵¹	9.2	GZMB, TNFRSF1B, EGFR, NRAS
20	Allograft rejection²⁹ Hide members Autoimmune thyroid disease²⁹ Intestinal immune network for IgA production²⁹ Asthma²⁹ Antigen processing and presentation²⁹ THC Differentiation Pathway⁵¹ Type I diabetes mellitus²⁹ Graft-versus-host disease²⁹ CTL Mediated Apoptosis⁵¹	9.2	CCL11, GZMB, TNFRSF1B, CD4, IL5
21	Signaling in Gap Junctions⁵¹ Hide members Gap junction²⁹	9.1	EGFR, NRAS, HRAS, KRAS
22	PIP3 activates AKT signaling⁵³ Hide members Signaling by SCF-KIT⁵³ Signaling by ERBB4⁵³ PI-3K cascade⁵³ PI3K events in ERBB2 signaling⁵³ PI3K events in ERBB4 signaling⁵³ GAB1 signalosome⁵³ PI3K/AKT Signaling in Cancer⁵³ Constitutive PI3K/AKT Signaling in Cancer⁵³ PI3K/AKT activation⁵³	9.1	KRAS, HRAS, NRAS, EGFR
23	EGFR1 Signaling Pathway³⁷	9.1	EGFR, NRAS, HRAS, KRAS
24	Hepatitis C²⁹	9.1	EGFR, NRAS, HRAS, KRAS
25	Development Angiotensin activation of ERK¹² Hide members Development EPO-induced MAPK pathway¹² Development EDNRB signaling¹² Development ACM2 and ACM4 activation of ERK¹² Development G-Proteins mediated regulation MARK-ERK signaling¹² Development Angiotensin signaling via PYK2¹²	9.1	KRAS, HRAS, NRAS, EGFR
26	Chronic myeloid leukemia²⁹ Hide members Pancreatic cancer²⁹	9.1	EGFR, NRAS, HRAS, KRAS
27	SHC-mediated signalling⁵³ Hide members Signaling by constitutively active EGFR⁵³ RAF phosphorylates MEK⁵³ EGFR Transactivation by Gastrin⁵³ MEK activation⁵³ GRB2 events in EGFR signaling⁵³ RAF activation⁵³ SHC1 events in EGFR signaling⁵³ SHC-related events⁵³ SOS-mediated signalling⁵³ RAF/MAP kinase cascade⁵³ Activation of RAS in B Cells⁵³ SHC-related events triggered by IGF1R⁵³ EGFR-dependent Endothelin signaling events³⁷	9.1	EGFR, NRAS, HRAS, KRAS
28	SHC1 events in ERBB2 signaling⁵³ Hide members GRB2 events in ERBB2 signaling⁵³ SHC1 events in ERBB4 signaling⁵³ ErbB receptor signaling network³⁷	9.1	EGFR, NRAS, HRAS, KRAS
29	Proteoglycans in cancer²⁹	9.1	EGFR, NRAS, HRAS, KRAS
30	G alpha (q) signalling events⁵³ Hide members Gastrin-CREB signalling pathway via PKC and MAPK⁵³	9.1	EGFR, NRAS, HRAS, KRAS
31	Endometrial cancer²⁹ Hide members Colorectal cancer²⁹ Acute myeloid leukemia²⁹ Signal transduction PTEN pathway¹²	9.1	EGFR, NRAS, HRAS, KRAS
32	ErbB signaling pathway²⁹ Hide members ErbB signaling pathway³⁷ EGFR Inhibitor Pathway, Pharmacodynamics⁴⁹	9.1	EGFR, NRAS, HRAS, KRAS
33	Fc epsilon receptor (FCERI) signaling⁵³ Hide members Role of LAT2/NTAL/LAB on calcium mobilization⁵³	9.1	KRAS, HRAS, NRAS, EGFR
34	Development Endothelin-1/EDNRA signaling Hide members Estrogen signaling pathway²⁹ GnRH signaling pathway²⁹ Development Endothelin-1/EDNRA signaling¹² Cytoskeleton remodeling FAK signaling¹² Development Endothelin-1/EDNRA transactivation of EGFR¹²	9.1	EGFR, NRAS, HRAS, KRAS
35	Regulation of Actin Cytoskeleton³⁷ Hide members Regulation of actin cytoskeleton²⁹	9.1	KRAS, HRAS, NRAS, EGFR
36	Rho Family GTPases⁵¹ Hide members Molecular Mechanisms of Cancer⁵¹ ERK Signaling⁵¹ MAPK Signaling⁵¹	9.1	TNFRSF1B, NRAS, CD4, IL5, HRAS
37	4-1BB Pathway⁵¹ Hide members NF-kappaB Activation by Viruses⁵¹ SUMO Pathway⁵¹ NF-KappaB Activation by EBV⁵¹ TNFR2 Pathway⁵¹	9.1	CD4, NRAS, EGFR, TNFRSF1B
38	TGF-Beta Pathway⁵¹ Hide members SOCS Pathway⁵¹ JAK-STAT Pathway⁵¹ Regulation of eIF4 and p70S6K⁵¹ MAPK Family Pathway⁵¹ JNK Pathway⁵¹	9.1	CCL11, CCL27, CD4, IL5
39	Interleukin-3, 5 and GM-CSF signaling⁵³ Hide members Signaling by Interleukins⁵³ Interleukin-2 signaling⁵³ Interleukin receptor SHC signaling⁵³ Signaling by Interleukins⁵³	9.0	NRAS, IL1RN, IL5, HRAS, KRAS
40	Interferon Signaling⁵³ Hide members Cytokine Signaling in Immune system⁵³ Cytokine Signaling in Immune system⁵³	9.0	NRAS, IL1RN, IL5, HRAS, KRAS
41	Apoptosis Pathway⁵⁹ Hide members NF-kappaB Pathway⁵⁹ Akt Pathway⁵⁹	8.9	EGFR, NRAS, IL5, HRAS, KRAS
42	Chemokine Signaling⁵¹ Hide members Chemokine signaling pathway²⁹	8.8	CCL11, CCL27, NRAS, HRAS, KRAS
43	Signaling by the B Cell Receptor (BCR)⁵³ Hide members Downstream Signaling Events Of B Cell Receptor (BCR)⁵³	8.8	KRAS, HRAS, CD79A, NRAS, EGFR
44	B cell receptor signaling pathway²⁹ Hide members T cell receptor signaling pathway²⁹ BCR signaling pathway³⁷ TCR Signaling Pathway³⁷	8.7	NRAS, CD4, CD79A, IL5, HRAS, KRAS
45	Immune response Fc epsilon RI pathway¹² Hide members VEGF signaling pathway²⁹ Fc epsilon RI signaling pathway²⁹ Natural killer cell mediated cytotoxicity²⁹ Immune response CD16 signaling in NK cells¹² Immune response IL-4 signaling pathway¹² Immune response BCR pathway¹² Fc-epsilon receptor I signaling in mast cells³⁷ Immune response Role of DAP12 receptors in NK cells¹²	8.6	KRAS, CCL11, GZMB, NRAS, CD79A, IL5
46	Integrin Pathway⁵¹ Hide members FAK1 Signaling⁵¹ GnRH Signaling⁵¹ UPA-UPAR Pathway⁵¹ Transendothelial Migration of Leukocytes⁵¹	8.6	HRAS, NRAS, EGFR, CCL27, CCL11
47	Immune System⁵³ Hide members Adaptive Immune System⁵³ Innate Immune System⁵³	7.8	NLRP3, EGFR, NRAS, CD4, CD79A, IL1RN
48	Akt Signaling⁵¹ Hide members p38 Signaling⁵¹ Tec Kinases Signaling⁵¹	7.8	IL5, CD4, NRAS, EGFR, TNFRSF1B, CCL27
49	PAK Pathway⁵¹ Hide members Epithelial Adherens Junctions⁵¹ Antioxidant Action of Vitamin-C⁵¹	7.8	CCL11, HRAS, IL5, CD4, NRAS, EGFR
50	PEDF Induced Signaling⁵¹ Hide members STAT3 Pathway⁵¹ IL-6 Pathway⁵¹ Endothelin-1 Signaling Pathway⁵¹ all-trans-Retinoic Acid Signaling in Brain⁵¹ Cytokine-cytokine receptor interaction²⁹ NFAT Signaling and Lymphocyte Interactions⁵¹ RAR-Gamma-RXR-Alpha Degradation⁵¹ PGC1Alpha Pathway⁵¹ Glucocorticoid Receptor Signaling⁵¹ MIF Regulation of Innate Immune Cells⁵¹ MIF Mediated Glucocorticoid Regulation⁵¹	7.8	CCL11, CCL27, TNFRSF1B, EGFR, NRAS, CD4

Compounds for genes affiliated with Exanthem

Sources:
⁴⁴Novoseek, ⁴⁹PharmGKB, ²⁸IUPHAR, ¹¹DrugBank, ²⁴HMDB, ⁵⁹Tocris Bioscience, ²BitterDB
See all sources

Compounds related to Exanthem according to GeneCards/GeneDecks:

(show top 50) (show all 81)

id	Compound	Score	Top Affiliating Genes
1	cycloheximide⁴⁴	10.4	CD4
2	amphotericin b⁴⁴	10.4	IL1RN
3	rantes⁴⁴	10.2	CD4, GZMB, CCL11
4	endotoxin⁴⁴	10.1	TNFRSF1B
5	unicap⁴⁴	10.1	CCL11, IL5, CD79A
6	sodium cromoglycate⁴⁴	10.0	IL5, CCL11, CD79A
7	allergens⁴⁴	9.8	CCL27, CCL11, IL5
8	con a⁴⁴	9.8	TNFRSF1B, CD79A, IL5
9	salbutamol⁴⁴ ⁴⁹ ²⁸ ¹¹ ²⁴	13.8	CCL11, IL5, CD79A
10	anakinra⁴⁴ ¹¹	10.7	NLRP3, CRP, IL1RN
11	clarithromycin⁴⁴ ¹¹	10.7	IL5, CCL11, CD79A, IL1RN
12	methacholine⁴⁴ ¹¹	10.6	IL5, CD79A, CCL11, CRP
13	adalimumab⁴⁴ ⁴⁹ ¹¹	11.6	CD79A, CRP, IL1RN
14	L-Tyrosine¹¹ ²⁴	10.6	GOT1, GOT2, EGFR
15	tarc⁴⁴	9.4	CCL27, CCL11, CD4, IL5
16	sulfasalazine⁴⁴ ²⁸ ⁴⁹ ¹¹	12.4	IL1RN, CD79A, CRP
17	hyaluronic acid⁴⁴ ²⁴	10.4	CD79A, CCL11, IL1RN, GZMB
18	polyethylene glycol⁴⁴	9.3	CRP, IL1RN, CD79A, TNFRSF1B
19	herbimycin a⁴⁴ ⁵⁹	10.3	HRAS, EGFR, IL5, CCL11, CD4
20	p002⁴⁴	9.3	TNFRSF1B, KRAS, IL1RN, CRP
21	oxygen⁴⁴ ²⁴	10.3	TNFRSF1B, CCL11, KRAS, HRAS, FTL, FTH1
22	heparin⁴⁴ ²⁸ ¹¹ ²⁴	12.3	IL1RN, CD79A, CCL11, GZMB, CD4
23	imatinib⁴⁴ ⁴⁹ ¹¹	11.3	KRAS, GZMB, IL5, EGFR
24	agar⁴⁴	9.2	NRAS, EGFR, IL5, HRAS, CD79A
25	chloroquine⁴⁴ ² ⁴⁹ ²⁸ ¹¹	13.2	CD79A, CD4, IL1RN, FTL, TNFRSF1B
26	vitamin d⁴⁴	9.1	TNFRSF1B, CD79A, IL1RN, IL5, KRAS
27	etanercept⁴⁴ ⁴⁹ ¹¹	11.0	IL1RN, CRP, TNFRSF1B
28	prednisolone⁴⁴ ²⁸ ¹¹	11.0	IL5, CD79A, IL1RN, CCL11, CRP, GZMB
29	rapamycin⁴⁴	9.0	KRAS, HRAS, EGFR, GZMB, CRP
30	ivig⁴⁴	9.0	CD79A, TNFRSF1B, GZMB, CRP, IL1RN, IL5
31	pge2⁴⁴	9.0	CD4, CCL11, HRAS, CCL27, EGFR
32	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	12.0	CD79A, CCL11, IL5, CCL27, GZMB, TNFRSF1B
33	sb 203580⁴⁴ ⁵⁹	9.9	EGFR, IL1RN, IL5, CCL11, CRP
34	paraffin⁴⁴	8.9	KRAS, HRAS, CD79A, IL5, GZMB, EGFR
35	cyclosporin a⁴⁴ ²⁸ ⁵⁹	10.9	IL1RN, CCL11, GZMB, TNFRSF1B, CD79A, IL5
36	genistein⁴⁴ ²⁸ ⁵⁹ ² ¹¹ ²⁴	13.9	HRAS, IL5, CD4, EGFR, CCL11
37	methotrexate⁴⁴ ⁴⁹ ¹¹	10.9	CD79A, TNFRSF1B, CRP, NLRP3, IL5, IL1RN
38	neopterin⁴⁴	8.9	TNFRSF1B, IL1RN, CD79A, CD4, CRP, GZMB
39	oligonucleotide⁴⁴	8.8	CD4, TNFRSF1B, KRAS, HRAS, NRAS, GZMB
40	cysteine⁴⁴	8.6	GZMB, IL1RN, CD4, TNFRSF1B, CD79A, HRAS
41	h2o2⁴⁴	8.5	TNFRSF1B, HRAS, KRAS, CD79A, FTH1, FTL
42	ly294002⁴⁴	8.4	GZMB, CCL11, TNFRSF1B, CRP, EGFR, HRAS
43	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	11.4	CD79A, TNFRSF1B, IL5, CRP, EGFR, IL1RN
44	estrogen⁴⁴	8.4	GZMB, EGFR, CD79A, IL1RN, HRAS, KRAS
45	alanine⁴⁴	8.2	IL1RN, CCL11, CD79A, CD4, CRP, GZMB
46	cholesterol⁴⁴ ²⁸ ¹¹ ²⁴	11.2	CRP, TNFRSF1B, FTL, CD4, IL1RN, HRAS
47	retinoic acid⁴⁴ ²⁴	9.1	CD79A, HRAS, IL5, IL1RN, TNFRSF1B, GZMB
48	tyrosine⁴⁴	7.9	HRAS, CCL11, EGFR, TNFRSF1B, GZMB, KRAS
49	vegf⁴⁴	7.6	CCL11, GZMB, TNFRSF1B, CRP, EGFR, CD79A
50	lipid⁴⁴	7.3	HRAS, KRAS, FTH1, TNFRSF1B, CD4, CCL27

GO Terms for genes affiliated with Exanthem

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Exanthem according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intracellular ferritin complex	GO:008043	9.9	FTL, FTH1
2	membrane raft	GO:045121	8.6	KRAS, CD79A, CD4, EGFR, TNFRSF1B
3	extracellular space	GO:005615	7.7	CCL11, CCL27, CRP, EGFR, IL1RN, IL5
4	plasma membrane	GO:005886	6.8	CRP, EGFR, NRAS, CD4, CD79A, IL1RN

Biological processes related to Exanthem according to GeneCards/GeneDecks:

(show all 26)

id	Name	GO ID	Score	Top Affiliating Genes
1	glutamate catabolic process to 2-oxoglutarate	GO:019551	10.1	GOT2, GOT1
2	glutamate catabolic process to aspartate	GO:019550	10.0	GOT2, GOT1
3	aspartate biosynthetic process	GO:006532	10.0	GOT2, GOT1
4	positive regulation of Rac protein signal transduction	GO:035022	10.0	KRAS, HRAS, NRAS
5	regulation of synaptic transmission, GABAergic	GO:032228	10.0	NRAS, HRAS, KRAS
6	striated muscle cell differentiation	GO:051146	10.0	NRAS, HRAS, KRAS
7	regulation of long-term neuronal synaptic plasticity	GO:048169	10.0	KRAS, HRAS, NRAS
8	aspartate metabolic process	GO:006531	10.0	GOT1, GOT2
9	aspartate catabolic process	GO:006533	10.0	GOT1, GOT2
10	visual learning	GO:008542	9.9	NRAS, HRAS, KRAS
11	oxaloacetate metabolic process	GO:006107	9.8	GOT1, GOT2
12	Ras protein signal transduction	GO:007265	9.8	NRAS, HRAS, KRAS
13	glutamate metabolic process	GO:006536	9.7	GOT2, GOT1
14	negative regulation of neuron apoptotic process	GO:043524	9.7	KRAS, HRAS, NRAS
15	response to glucocorticoid stimulus	GO:051384	9.7	GOT1, KRAS, IL1RN
16	positive regulation of MAP kinase activity	GO:043406	9.6	EGFR, HRAS, KRAS
17	activation of MAPKK activity	GO:000186	9.5	KRAS, HRAS, NRAS, EGFR
18	MAPK cascade	GO:000165	9.5	EGFR, NRAS, HRAS, KRAS
19	fibroblast growth factor receptor signaling pathway	GO:008543	9.4	KRAS, HRAS, NRAS, EGFR
20	Fc-epsilon receptor signaling pathway	GO:038095	9.3	EGFR, NRAS, HRAS, KRAS
21	inflammatory response	GO:006954	9.3	CCL11, NLRP3, TNFRSF1B, CRP, IL5
22	epidermal growth factor receptor signaling pathway	GO:007173	9.3	EGFR, NRAS, HRAS, KRAS
23	positive regulation of protein phosphorylation	GO:001934	9.3	KRAS, HRAS, EGFR
24	neurotrophin TRK receptor signaling pathway	GO:048011	8.8	EGFR, NRAS, HRAS, KRAS
25	innate immune response	GO:045087	8.8	NLRP3, EGFR, NRAS, CD4, HRAS, KRAS
26	immune response	GO:006955	8.5	IL5, CCL11, CCL27, TNFRSF1B, FTH1, CD4

Molecular functions related to Exanthem according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ferric iron binding	GO:008199	10.0	FTH1, FTL
2	L-aspartate:2-oxoglutarate aminotransferase activity	GO:004069	9.6	GOT1, GOT2
3	L-phenylalanine:2-oxoglutarate aminotransferase activity	GO:080130	9.4	GOT1, GOT2