Exanthem disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Exanthem

Sources:
³³MedlinePlus, ⁶⁴Wikipedia, ³²MalaCards
See all sources

Looking for an antibody for researching exanthem?

FTH1 antibody
GOT1 antibody
GZMB antibody
NLRP3 antibody
NRAS antibody
TNFRSF1B antibody
CD79A antibody
FTL antibody
HRAS antibody
IL5 antibody

MedlinePlus:³³ A rash is an area of irritated or swollen skin. many rashes are itchy, red, painful, and irritated. some rashes can also lead to blisters or patches of raw skin. rashes are a symptom of many different medical problems. other causes include irritating substances and allergies. certain genes can make people more likely to get rashes. contact dermatitis is a common type of rash. it causes redness, itching, and sometimes small bumps. you get the rash where you have touched an irritant, such as a chemical, or something you are allergic to, like poison ivy. some rashes develop right away. others form over several days. although most rashes clear up fairly quickly, others are long-lasting and need long-term treatment. because rashes can be caused by many different things, it's important to figure out what kind you have before you treat it. if it is a bad rash, if it does not go away, or if you have other symptoms, you should see your health care provider. treatments may include moisturizers, lotions, baths, cortisone creams that relieve swelling, and antihistamines, which relieve itching.

MalaCards based summary: Exanthem, also known as exanthema, is related to eosinophilia and hepatitis. An important gene associated with Exanthem is FTH1 (ferritin, heavy polypeptide 1), and among its related pathways are Fc-GammaR Pathway and Renal cell carcinoma. The compounds 3-Sulfinylpyruvic acid and 3-Sulfopyruvic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and brain, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Wikipedia:⁶⁴ An exanthem (from Greek ???????? exanthema, \"a breaking out\") is a widespread rash usually occurring... more...

Aliases & Classifications for Exanthem

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁶¹UMLS, ³³MedlinePlus, ³⁴MeSH
See all sources

Exanthem, Aliases & Descriptions:

Name: Exanthem ⁹ ¹¹

Exanthema ⁹ ⁶¹

Rashes ³³

Rash ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases

External Ids:

Disease Ontology⁹ DOID:0050486

MeSH³⁴ D005076

Related Diseases for Exanthem

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Exanthem family:

Bacterial Exanthem	Viral Exanthem

Diseases related to Exanthem via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 200)

id	Related Disease	Score	Top Affiliating Genes
1	eosinophilia	30.3	CCL11, CD79A, IL5
2	hepatitis	30.3	CCL11, GZMB, KRAS
3	thrombocytopenia	30.3	CD79A, GOT2, GOT1
4	vasculitis	30.0	CD79A, CRP, TNFRSF1B
5	dermatitis	30.0	CD79A, NLRP3, GZMB, IL5, CCL11, TNFRSF1B
6	leukemia	29.9	CCL11, NRAS, GZMB, KRAS, HRAS, CD79A
7	pneumonia	29.9	TNFRSF1B, CD79A, CRP, IL5, CCL11
8	hepatitis c	29.8	GOT1, GOT2, FTL, KRAS, FTH1
9	hepatitis b	29.5	CD79A, GZMB, GOT1, GOT2, HRAS, KRAS
10	arthritis	29.4	FTH1, FTL, TNFRSF1B, GZMB, CRP, IL1RN
11	pancreatitis	29.2	CRP, KRAS, HRAS, NRAS, GOT1, GOT2
12	gastroenteritis	10.5	CD79A
13	muckle-wells syndrome	10.5	NLRP3
14	giardiasis	10.5	CD79A
15	amebiasis	10.5	CD79A
16	poems syndrome	10.5	CD79A
17	strongyloidiasis	10.5	IL5
18	cryptosporidiosis	10.5	CD79A
19	aspergillosis	10.5	CD79A
20	gallbladder disease	10.5	GOT2, GOT1
21	hyper-igd syndrome	10.5	IL1RN
22	viral exanthem	10.5
23	schnitzler syndrome	10.4	IL1RN
24	conjunctivitis	10.4	NLRP3, CD79A
25	nutritional deficiency disease	10.4	FTH1, FTL
26	reye syndrome	10.4	GOT1, GOT2
27	hepatitis a	10.4	GOT2, GOT1
28	measles	10.4
29	dermatitis herpetiformis	10.4	CD79A, CCL11
30	cardiofaciocutaneous syndrome	10.4	KRAS
31	hemosiderosis	10.4	FTL, FTH1
32	bronchiolitis	10.4	CCL11, IL5
33	thyroid carcinoma, follicular, somatic	10.4	NRAS, HRAS
34	vitamin b12 deficiency	10.4	FTL, FTH1
35	chronic eosinophilic pneumonia	10.4	IL5, CCL11
36	giant papillary conjunctivitis	10.4	IL5, CCL11
37	porphyria cutanea tarda	10.4	FTH1, FTL
38	allergic conjunctivitis	10.4	IL5, CCL11
39	eosinophilic gastroenteritis	10.4	CCL11, IL5
40	folliculitis	10.4	CCL11, EGFR
41	siderosis	10.4	FTL, FTH1
42	eosinophilic esophagitis	10.4	IL5, CCL11
43	keratoconjunctivitis	10.4	CCL11, IL5
44	eosinophilic pneumonia	10.4	CCL11, IL5
45	pulmonary eosinophilia	10.3	CCL11, IL5
46	cholangitis	10.3	GOT1, GOT2
47	allergic rhinitis	10.3	CCL11, IL5
48	hemophagocytic lymphohistiocytosis	10.3	GZMB, FTL, FTH1
49	chronic infantile neurological cutaneous articular syndrome	10.3	NLRP3, IL1RN
50	acute pyelonephritis	10.3	CRP

Graphical network of the top 20 diseases related to Exanthem:

Symptoms for Exanthem

Drugs & Therapeutics for Exanthem

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Exanthem

Search NIH Clinical Center for Exanthem

Genetic Tests for Exanthem

Anatomical Context for Exanthem

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Exanthem:

³²

Skin, T cells, Brain, Spinal cord, Liver, Breast, Prostate, Testes, Myeloid, Neutrophil

Animal Models for Exanthem or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Exanthem:

³⁶ (show all 14)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	7.9	TNFRSF1B, NLRP3, KRAS, CD79A, EGFR, HRAS
2	liver/biliary system phenotype	MP:0005370	7.9	TNFRSF1B, FTH1, IL5, NRAS, NLRP3, KRAS
3	respiratory system phenotype	MP:0005388	7.8	TNFRSF1B, CCL11, IL5, KRAS, EGFR, HRAS
4	digestive/alimentary phenotype	MP:0005381	7.8	TNFRSF1B, IL5, NRAS, NLRP3, KRAS, EGFR
5	normal phenotype	MP:0002873	7.8	CCL11, NRAS, NLRP3, KRAS, CD79A, EGFR
6	tumorigenesis	MP:0002006	7.8	TNFRSF1B, IL5, NRAS, GZMB, KRAS, EGFR
7	nervous system phenotype	MP:0003631	7.6	FTH1, NLRP3, KRAS, CD79A, EGFR, HRAS
8	integument phenotype	MP:0010771	7.6	TNFRSF1B, IL1RN, NRAS, NLRP3, KRAS, EGFR
9	cellular phenotype	MP:0005384	7.2	TNFRSF1B, FTH1, IL1RN, NRAS, GZMB, NLRP3
10	cardiovascular system phenotype	MP:0005385	7.1	TNFRSF1B, FTH1, IL1RN, CRP, NRAS, KRAS
11	mortality/aging	MP:0010768	6.7	TNFRSF1B, FTH1, IL1RN, NRAS, GZMB, NLRP3
12	hematopoietic system phenotype	MP:0005397	6.6	IL5, CCL11, FTH1, TNFRSF1B, IL1RN, NRAS
13	immune system phenotype	MP:0005387	6.0	EGFR, TNFRSF1B, FTH1, CCL11, IL5, IL1RN
14	homeostasis/metabolism phenotype	MP:0005376	5.9	CRP, IL1RN, IL5, FTH1, TNFRSF1B, NRAS

Publications for Exanthem

Sources:
⁵¹PubMed
See all sources

Articles related to Exanthem:

(show top 50) (show all 230)

id	Title	Authors	Year
1	Unilateral laterothoracic or asymmetric periflexural exanthem: is time to change the name of the disease? (25267301)	Drago F.... Rebora A.	2014
2	Black heel (talon noir) associated with a viral exanthem. (24222298)	Sardana K.... Sagar V.	2013
3	Febrile illness with papular and vesicular exanthem and ulceronecrotic plaques. (23106676)	Castelo-Soccio L.A.... Shah K.N.	2012
4	Generalized purpuric drug exanthem with hemorrhagic plaques following bendamustine chemotherapy in a patient with B-prolymphocytic leukemia. (22290027)	Gavini A.... Olszewski A.J.	2012
5	Asymmetrical periflexural exanthem exhibiting pseudoisomorphic KAPebner response in an adult. (19094120)	Dar N.R.... Raza N.	2009
6	Symmetrical drug-related intertriginous and flexural exanthem due to oral risperidone. (19419476)	Akay B.N.... Sanli H.	2009
7	Unilateral laterothoracic exanthem and primary Epstein-Barr virus infection: case report. (19483526)	Duarte A.F.... Azevedo F.	2009
8	The exanthem of dengue fever: Clinical features of two US tourists traveling abroad. (17959270)	Pincus L.B.... Fox L.P.	2008
9	An atypical varicella exanthem associated with the use of infliximab. (16911403)	Choi H.J.... Park Y.M.	2006
10	Drug-induced exanthems. (15767025)	Yawalkar N.	2005
11	Histopathology of drug-induced exanthems: is there a role in diagnosis of drug allergy? (15985813)	BrAPnnimann M.... Yawalkar N.	2005
12	Petechial exanthem in "bathing trunk" distribution caused by parvovirus B19 infection. (16190994)	Huerta-Brogeras M.... Longo-Imedio M.I.	2005
13	Dapsone hypersensitivity syndrome masquerading as a viral exanthem: three cases and a mini-review. (15175785)	Tee A.K.... Poh W.T.	2004
14	Asymmetric periflexural exanthem of childhood in a child with axonal Guillain-BarrAc syndrome. (14996133)	Auvin S.... Martinot A.	2004
15	Asymmetric periflexural exanthem in an adult. (15115527)	Chan P.K.... Chuh A.A.	2004
16	Enoxaparin-induced generalized exanthem. (12889716)	Kim K.H.... Lynfield Y.	2003
17	Measles: an exanthem that can be eradicated. (12826456)	John T.J.	2003
18	Atypical exanthem: polymerase chain reaction spots the cause. (12890217)	Harris A.J.... MacMahon E.M.	2003
19	Asymmetric periflexural exanthem of childhood in an adult patient with parvovirus B19. (11730065)	Pauluzzi P.... Gelmetti C.	2001
20	Asymmetric periflexural exanthem of childhood: microbiologic case-control study. (10886745)	Coustou D.... TaA^eb A.	2000
21	Unilateral laterothoracic exanthem in a child with acute lymphoblastic leukemia. (9496806)	Fort D.W.... Greer K.E.	1998
22	Distribution of human herpesvirus 6 and varicella-zoster virus in organs of a fatal case with exanthem subitum and varicella. (9002291)	Ueda T.... Asano Y.	1996
23	Detection of human herpesvirus 6 DNAs in samples from several body sites of patients with exanthem subitum and their mothers by polymerase chain reaction assay. (7623007)	Suga S.... Asano Y.	1995
24	Erythematous exanthem associated with primary infection by human parvovirus B19. (7737770)	Veraldi S.... Rizzitelli G.	1995
25	Mercury exanthem. (7842674)	Vena G.A.... Angelini G.	1994
26	Asymmetric periflexural exanthem of childhood: report of two new cases. (8170849)	Gelmetti C.... Caputo R.	1994
27	Deficiency of the beta subunit of the eighth component of complement presenting as arthritis and exanthem. (7980680)	Wulffraat N.M.... Zegers B.J.	1994
28	Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). (8265302)	Asano Y.... Ozaki T.	1994
29	Papular-purpuric gloves and socks syndrome: a characteristic viral exanthem. (8233753)	Stone M.S.... Murph J.R.	1993
30	Outbreak of exanthem subitum in an orphanage. (1658282)	Okuno T.... Yamanishi K.	1991
31	Detection by polymerase chain reaction amplification of human herpesvirus 6 DNA in peripheral blood of patients with exanthem subitum. (2351740)	Kondo K.... Yamanishi K.	1990
32	Transmission of chickenpox in a school setting prior to the observed exanthem. (2556025)	Brunell P.A.	1989
33	Human herpesvirus-6 infection (exanthem subitum) without rash. (2542875)	Suga S.... Hirata S.	1989
34	Viremia and neutralizing antibody response in infants with exanthem subitum. (2647944)	Asano Y.... Yoshida S.	1989
35	Human herpesvirus type 6 infection (exanthem subitum) without fever. (2547050)	Asano Y.... Yazaki T.	1989
36	Human herpesvirus 6 and exanthem subitum. (2898616)	Takahashi K.... Kamanishi K.	1988
37	Immunophenotypic characterization of the cutaneous exanthem of SIV-infected rhesus monkeys. Apposition of degenerative Langerhans cells and cytotoxic lymphocytes during the development of acquired immunodeficiency syndrome. (3030113)	Ringler D.J.... Murphy G.F.	1987
38	Photodistribution of varicella exanthem: report of two cases. (3725698)	Serrano G.... Otero D.	1986
39	A probable case of rotavirus exanthem. (3977344)	Ruzicka T.... Braun-Falco O.	1985
40	Exanthem in northwestern Tasmania. (6843451)	Shugg A.W.	1983
41	Mercury exanthem. (6194931)	Nakayama H.... Hada S.	1983
42	Filatow-Dukes' disease. Epidermolytic toxin-producing staphylococci as the etiologic agent of the fourth childhood exanthem. (367152)	Powell K.R.	1979
43	Exanthem due to diphenylhydantoin therapy. (4245455)	ROBINSON H.M.... Stone J.H.	1970
44	Search for Mycoplasma pneumoniae infection in patients with exanthem but without pneumonia. (5654564)	Cherry J.D.... Sueltmann S.	1968
45	Echovirus type 18 infection: an unusual exanthem. (5939742)	Wedemeyer P.P.... St GEME J.W.	1966
46	OUTBREAKS OF A PAPULO-VESICULAR EXANTHEM ON THE HANDS AND FEET ("SUMMER-TERM BLAINS"). (14135166)	Warin R.P.... WALLIS H.R.	1964
47	Vesicular stomatitis and exanthem. A syndrome associated with Coxsackie virus, type A16. (13765313)	MAGOFFIN R.L.... LENNETTE E.H.	1961
48	The virus aetiology of epidemic exanthem and polyarthritis. (14446161)	Shope R.E.... ANDERSON S.G.	1960
49	An epidemic exanthem associated with polyarthritis in the Murray valley, 1956. (13464271)	ANDERSON S.G.... FRENCH E.L.	1957
50	Exanthem Subitum-Report of Five Cases. (20314150)	Goldbloom A.	1922

Genes related to Exanthem

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Exanthem:

(show all 16)

- Elite gene

id	Symbol	Description	Score	Implication
1	FTH1	ferritin, heavy polypeptide 1	20.59	GeneCards inferred via : Disorders (show sections)
2	GOT1	glutamic-oxaloacetic transaminase 1, soluble	19.34	GeneCards inferred via : Disorders (show sections)
3	CCL11	chemokine (C-C motif) ligand 11	18.09	GeneCards inferred via : Publications (show sections)
4	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	16.84	GeneCards inferred via : Publications (show sections)
5	NLRP3	NLR family, pyrin domain containing 3	15.59	GeneCards inferred via : Disorders (show sections)
6	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	14.34	GeneCards inferred via : Disorders (show sections)
7	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	13.09	GeneCards inferred via : Disorders (show sections)
8	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.84	GeneCards inferred via : Disorders (show sections)
9	FTL	ferritin, light polypeptide	10.59	GeneCards inferred via : Disorders (show sections)
10	HRAS	Harvey rat sarcoma viral oncogene homolog	9.34	GeneCards inferred via : Disorders (show sections)
11	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	8.09	GeneCards inferred via : Publications (show sections)
12	IL1RN	interleukin 1 receptor antagonist	6.84	GeneCards inferred via : Disorders (show sections)
13	KRAS	Kirsten rat sarcoma viral oncogene homolog	5.59	GeneCards inferred via : Disorders (show sections)
14	CRP	C-reactive protein, pentraxin-related	4.34	GeneCards inferred via : Disorders (show sections)
15	EGFR	epidermal growth factor receptor	3.09	GeneCards inferred via : Disorders (show sections)
16	GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial	1.84	GeneCards inferred via : Disorders (show sections)

Products for genes related to Exanthem disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	15	-	15	15
2	Novus Biologicals	16	14	16	-

Variations for Exanthem

Expression for genes affiliated with Exanthem

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Exanthem

Search GEO for disease gene expression data for Exanthem.

Pathways for genes affiliated with Exanthem

Sources:
⁴⁹PathCards, ⁵²QIAGEN, ³⁰KEGG, ⁵⁴Reactome, ⁵⁹Thomson Reuters, ⁵⁰PharmGKB, ⁵⁵SinoBiological, ³⁷NCBI BioSystems Database, ⁵³R&D Systems, ⁶⁰Tocris Bioscience
See all sources

Pathways related to Exanthem according to GeneCards/GeneDecks:

(show top 50) (show all 91)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Fc-GammaR Pathway⁵² Show member pathways Fc-Gamma-RIIB Signaling in B-Cells⁵²	9.5	HRAS, CD79A, NRAS
2	Renal cell carcinoma³⁰	9.3	NRAS, KRAS, HRAS
3	Thyroid cancer³⁰	9.3	NRAS, KRAS, HRAS
4	FGFR ligand binding and activation⁵⁴ Show member pathways FGFR1c and Klotho ligand binding and activation⁵⁴ Signaling by FGFR2 amplification mutants⁵⁴ Klotho-mediated ligand binding⁵⁴ FGFR2 ligand binding and activation⁵⁴ Negative regulation of FGFR signaling⁵⁴ FRS2-mediated cascade⁵⁴ Signaling by FGFR1 amplification mutants⁵⁴ FGFR1b ligand binding and activation⁵⁴ SHC-mediated cascade⁵⁴ FGFR4 ligand binding and activation⁵⁴ betaKlotho-mediated ligand binding⁵⁴ Signaling by FGFR2 mutants⁵⁴ Signaling by FGFR4 mutants⁵⁴ Development FGF family signaling⁵⁹ FGFR1 ligand binding and activation⁵⁴ Spry regulation of FGF signaling⁵⁴ FGFR2c ligand binding and activation⁵⁴ FGFR2b ligand binding and activation⁵⁴ Activated point mutants of FGFR2⁵⁴	9.3	NRAS, KRAS, HRAS
5	NCAM signaling for neurite out-growth⁵⁴ Show member pathways NCAM1 interactions⁵⁴	9.3	NRAS, KRAS, HRAS
6	VEGF Signaling Pathway⁵⁰ Show member pathways VEGF Signaling⁵⁵	9.3	NRAS, KRAS, HRAS
7	Signaling by FGFR1 mutants⁵⁴ Show member pathways Signaling by FGFR1 fusion mutants⁵⁴ Signaling by FGFR mutants⁵⁴	9.3	HRAS, KRAS, NRAS
8	Long-term depression³⁰	9.3	HRAS, KRAS, NRAS
9	Signalling to ERKs⁵⁴ Show member pathways Prolonged ERK activation events⁵⁴ p38MAPK events⁵⁴ Signalling to RAS⁵⁴ Signalling to p38 via RIT and RIN⁵⁴ Frs2-mediated activation⁵⁴ ARMS-mediated activation⁵⁴	9.3	HRAS, KRAS, NRAS
10	Bisphosphonate Pathway, Pharmacodynamics⁵⁰	9.3	HRAS, KRAS, NRAS
11	Allograft rejection³⁰ Show member pathways Autoimmune thyroid disease³⁰ Viral myocarditis³⁰ Intestinal immune network for IgA production³⁰ Allograft Rejection³⁷ Asthma³⁰ Type I diabetes mellitus³⁰ Graft-versus-host disease³⁰ CTL Mediated Apoptosis⁵² Antigen processing and presentation³⁰ THC Differentiation Pathway⁵²	9.3	GZMB, IL5, CCL11, TNFRSF1B
12	IL-5 Signaling Pathway³⁷	9.2	IL5, KRAS, HRAS
13	Chemokine Signaling⁵² Show member pathways Chemokine signaling pathway³⁰	9.1	HRAS, KRAS, NRAS, CCL11
14	Immune response Role of DAP12 receptors in NK cells⁵⁹ Show member pathways Immune response CD16 signaling in NK cells⁵⁹ Natural killer cell mediated cytotoxicity³⁰	9.0	NRAS, GZMB, KRAS, HRAS
15	Agrin Interactions at Neuromuscular Junction⁵²	9.0	NRAS, EGFR, HRAS
16	Antigen Activates B Cell Receptor Leading to Generation of Second Messengers⁵⁴ Show member pathways FCERI mediated Ca+2 mobilization⁵⁴ FCERI mediated MAPK activation⁵⁴ B-Cell Receptor Complex⁵²	9.0	NRAS, KRAS, CD79A, HRAS
17	Prolactin signaling pathway³⁰ Show member pathways Prolactin Signaling Pathway³⁷ Development Prolactin receptor signaling⁵⁹ Leptin signaling pathway³⁷	8.8	HRAS, KRAS, NRAS, IL1RN
18	4-1BB Pathway⁵² Show member pathways CD40 Signaling⁵² PKR Pathway⁵² NF-kappaB Activation by Viruses⁵² CMV and MAPK Pathways⁵² SUMO Pathway⁵² NF-KappaB Activation by EBV⁵² TNFR2 Pathway⁵² CD27 Pathway⁵²	8.7	TNFRSF1B, NRAS, EGFR, HRAS
19	Immune response Fc epsilon RI pathway⁵⁹ Show member pathways VEGF - VEGF R2 Signaling Pathways⁵³ VEGF signaling pathway³⁰ Immune response BCR pathway⁵⁹ Fc epsilon RI signaling pathway³⁰ Fc-epsilon receptor I signaling in mast cells³⁷	8.6	IL5, NRAS, KRAS, CD79A, HRAS
20	B Cell Receptor Signaling Pathway³⁷ Show member pathways B cell receptor signaling pathway³⁰ BCR signaling pathway³⁷ TCR Signaling Pathway³⁷ T cell receptor signaling pathway³⁰	8.6	IL5, NRAS, KRAS, CD79A, HRAS
21	Proteoglycans in cancer³⁰	8.5	NRAS, KRAS, EGFR, HRAS
22	Gastrin-CREB signalling pathway via PKC and MAPK⁵⁴ Show member pathways G alpha (q) signalling events⁵⁴	8.5	HRAS, EGFR, KRAS, NRAS
23	Chronic myeloid leukemia³⁰ Show member pathways Pancreatic cancer³⁰	8.5	NRAS, KRAS, EGFR, HRAS
24	Development HGF signaling pathway⁵⁹ Show member pathways Development EGFR signaling via PIP3⁵⁹ Development PDGF signaling via MAPK cascades⁵⁹ Apoptosis and survival Anti apoptotic action of membrane bound ESR1⁵⁹ Signaling of Hepatocyte Growth Factor Receptor³⁷ Neurotrophin signaling pathway³⁰ Development EGFR signaling via small GTPases⁵⁹ Development Neurotrophin family signaling⁵⁹ Apoptosis and survival NGF signaling pathway⁵⁹ Apoptosis and survival Role of CDK5 in neuronal death and survival⁵⁹	8.5	HRAS, EGFR, KRAS, NRAS
25	Development Endothelin 1 EDNRA signaling⁵⁹ Show member pathways Inflammatory mediator regulation of TRP channels³⁰ Estrogen signaling pathway³⁰ GnRH signaling pathway³⁰ Cytoskeleton remodeling FAK signaling⁵⁹ Development Endothelin 1 EDNRA transactivation of EGFR⁵⁹	8.5	NRAS, KRAS, EGFR, HRAS
26	SHC1 events in ERBB2 signaling⁵⁴ Show member pathways Signaling by Leptin⁵⁴ ERK2 activation⁵⁴ RAF phosphorylates MEK⁵⁴ ERK1 activation⁵⁴ GRB2 events in ERBB2 signaling⁵⁴ MEK activation⁵⁴ GRB2 events in EGFR signaling⁵⁴ RAF activation⁵⁴ SHC1 events in EGFR signaling⁵⁴ ERK activation⁵⁴ RAF/MAP kinase cascade⁵⁴ SHC1 events in ERBB4 signaling⁵⁴	8.5	NRAS, KRAS, EGFR, HRAS
27	PI-3K cascade⁵⁴ Show member pathways Downregulation of ERBB4 signaling⁵⁴ AKT phosphorylates targets in the nucleus⁵⁴ Signaling by SCF-KIT⁵⁴ PI3K events in ERBB2 signaling⁵⁴ Fc epsilon receptor (FCERI) signaling⁵⁴ PI3K events in ERBB4 signaling⁵⁴ Signaling by ERBB4⁵⁴ GAB1 signalosome⁵⁴ Negative regulation of the PI3K/AKT network⁵⁴ Role of LAT2/NTAL/LAB on calcium mobilization⁵⁴ PIP3 activates AKT signaling⁵⁴ Regulation of KIT signaling⁵⁴ AKT phosphorylates targets in the cytosol⁵⁴ AKT-mediated inactivation of FOXO1A⁵⁴ PI3K/AKT Signaling in Cancer⁵⁴ Constitutive PI3K/AKT Signaling in Cancer⁵⁴ PI3K/AKT activation⁵⁴	8.5	HRAS, EGFR, KRAS, NRAS
28	Sorafenib Pharmacodynamics⁵⁰ Show member pathways VEGF Pathway⁶⁰ Vemurafenib Pathway, Pharmacodynamics⁵⁰	8.5	HRAS, EGFR, KRAS, NRAS
29	Glioma³⁰ Show member pathways Melanoma³⁰ Non-small cell lung cancer³⁰ Bladder cancer³⁰ Prostate cancer³⁰ Signaling Pathways in Glioblastoma³⁷	8.5	NRAS, KRAS, EGFR, HRAS
30	Regulation of Actin Cytoskeleton³⁷ Show member pathways Regulation of actin cytoskeleton³⁰	8.5	NRAS, KRAS, EGFR, HRAS
31	Oxytocin signaling pathway³⁰ Show member pathways Vascular smooth muscle contraction³⁰	8.5	NRAS, KRAS, EGFR, HRAS
32	Endometrial cancer³⁰ Show member pathways Colorectal cancer³⁰ Signal transduction PTEN pathway⁵⁹ Acute myeloid leukemia³⁰	8.5	NRAS, KRAS, EGFR, HRAS
33	EGFR Transactivation by Gastrin⁵⁴ Show member pathways EGFR-dependent Endothelin signaling events³⁷	8.5	HRAS, EGFR, KRAS, NRAS
34	Hepatitis C³⁰	8.5	NRAS, KRAS, EGFR, HRAS
35	Signaling in Gap Junctions⁵² Show member pathways Gap junction³⁰	8.5	NRAS, KRAS, EGFR, HRAS
36	FoxO signaling pathway³⁰ Show member pathways PLK2 and PLK4 events³⁷ Polo-like kinase signaling events in the cell cycle³⁷	8.5	NRAS, KRAS, EGFR, HRAS
37	ErbB signaling pathway³⁰ Show member pathways ErbB receptor signaling network³⁷ ErbB signaling pathway³⁷ EGFR Inhibitor Pathway, Pharmacodynamics⁵⁰	8.5	NRAS, KRAS, EGFR, HRAS
38	EGFR1 Signaling Pathway³⁷	8.5	NRAS, KRAS, EGFR, HRAS
39	DREAM Repression and Dynorphin Expression⁵² Show member pathways Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels⁵⁴ Calpain Protease Regulates Cellular Mechanics⁵² BMP Pathway⁵² TOB in Osteoblast Signaling⁵² Caspase Cascade⁵² nNOS Signaling in Skeletal Muscle⁵²	8.4	TNFRSF1B, NRAS, GZMB, EGFR, HRAS
40	Interferon Signaling⁵⁴ Show member pathways ISG15 antiviral mechanism⁵⁴ Cytokine Signaling in Immune system⁵⁴ Regulation of IFNG signaling⁵⁴ Interferon gamma signaling⁵⁴ Antiviral mechanism by IFN-stimulated genes⁵⁴	8.4	IL5, IL1RN, NRAS, KRAS, HRAS
41	Signaling by Interleukins⁵⁴ Show member pathways Interleukin-3, 5 and GM-CSF signaling⁵⁴ Interleukin-1 processing⁵⁴ Regulation of signaling by CBL⁵⁴ Interleukin-6 signaling⁵⁴ Interleukin-2 signaling⁵⁴ Interleukin-7 signaling⁵⁴ Interleukin receptor SHC signaling⁵⁴	8.4	IL5, IL1RN, NRAS, KRAS, HRAS
42	Development Angiotensin activation of ERK⁵⁹ Show member pathways Development EDNRB signaling⁵⁹ Development ACM2 and ACM4 activation of ERK⁵⁹ Cell adhesion Integrin inside out signaling⁵⁹ Development G Proteins mediated regulation MARK ERK signaling⁵⁹ Signal transduction IP3 signaling⁵⁹ Development Angiotensin signaling via PYK2⁵⁹ Development EPO induced MAPK pathway⁵⁹	8.2	NRAS, KRAS, CD79A, EGFR, HRAS
43	Downstream Signaling Events Of B Cell Receptor (BCR)⁵⁴ Show member pathways Signaling by the B Cell Receptor (BCR)⁵⁴ Activation of RAS in B Cells⁵⁴	8.2	NRAS, KRAS, CD79A, EGFR, HRAS
44	Apoptosis Pathway⁶⁰ Show member pathways Akt Pathway⁶⁰ NF-kappaB Pathway⁶⁰	8.1	HRAS, EGFR, KRAS, NRAS, IL5
45	PEDF Induced Signaling⁵² Show member pathways all-trans-Retinoic Acid Signaling in Brain⁵² Cytokine-cytokine receptor interaction³⁰ NFAT Signaling and Lymphocyte Interactions⁵² STAT3 Pathway⁵² RAR-Gamma-RXR-Alpha Degradation⁵² PGC1Alpha Pathway⁵² Glucocorticoid Receptor Signaling⁵² IL-6 Pathway⁵² Endothelin-1 Signaling Pathway⁵² MIF Regulation of Innate Immune Cells⁵² MIF Mediated Glucocorticoid Regulation⁵²	8.0	TNFRSF1B, CCL11, IL5, NRAS, EGFR, HRAS
46	ERK Signaling⁵² Show member pathways ILK Signaling⁵² Molecular Mechanisms of Cancer⁵² Rho Family GTPases⁵² MAPK Signaling⁵²	8.0	TNFRSF1B, CCL11, IL5, NRAS, EGFR, HRAS
47	Akt Signaling⁵² Show member pathways p38 Signaling⁵² Tec Kinases Signaling⁵²	8.0	TNFRSF1B, CCL11, IL5, NRAS, EGFR, HRAS
48	PAK Pathway⁵² Show member pathways Epithelial Adherens Junctions⁵² Antioxidant Action of Vitamin-C⁵²	8.0	TNFRSF1B, CCL11, IL5, NRAS, EGFR, HRAS
49	TGF-Beta Pathway⁵² Show member pathways SOCS Pathway⁵² JAK-STAT Pathway⁵² Regulation of eIF4 and p70S6K⁵² JNK Pathway⁵² MAPK Family Pathway⁵²	8.0	TNFRSF1B, CCL11, IL5, NRAS, EGFR, HRAS
50	NOD-like Receptor Signaling Pathways⁵³ Show member pathways Toll-Like receptor Signaling Pathways⁵³ Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways⁵³ Inflammasome Activation Pathways⁵³ Mucin expression in CF via TLRs, EGFR signaling pathways⁵⁹ IL-1 Family Signaling Pathways⁵³ Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways⁵⁹ Immune response IL 1 signaling pathway⁵⁹	8.0	IL1RN, NLRP3, KRAS, EGFR, HRAS

Compounds for genes affiliated with Exanthem

Sources:
²⁵HMDB, ⁴⁴Novoseek, ⁵⁰PharmGKB, ²⁹IUPHAR, ¹²DrugBank, ³BitterDB, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Exanthem according to GeneCards/GeneDecks:

(show top 50) (show all 119)

id	Compound	Score	Top Affiliating Genes
1	3-Sulfinylpyruvic acid²⁵	10.0	GOT2, GOT1
2	3-Sulfopyruvic acid²⁵	10.0	GOT2, GOT1
3	unicap⁴⁴	9.9	CD79A, IL5, CCL11
4	sodium cromoglycate⁴⁴	9.9	CD79A, IL5, CCL11
5	con a⁴⁴	9.7	CD79A, TNFRSF1B, IL5
6	salbutamol⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.7	CCL11, CD79A, IL5
7	anakinra⁴⁴ ¹²	10.5	IL1RN, CRP, NLRP3
8	hyaluronic acid⁴⁴ ²⁵	10.5	GZMB, CD79A, CCL11, IL1RN
9	clarithromycin⁴⁴ ¹²	10.5	CD79A, IL1RN, IL5, CCL11
10	allergens⁴⁴	9.4	CD79A, IL1RN, IL5, CCL11
11	chloroquine⁴⁴ ³ ⁵⁰ ²⁹ ¹²	13.4	IL1RN, CD79A, FTL, TNFRSF1B
12	adalimumab⁴⁴ ⁵⁰ ¹²	11.4	IL1RN, CD79A, CRP
13	amphotericin b⁴⁴	9.3	CRP, IL5, IL1RN
14	methacholine⁴⁴ ⁵⁰ ¹²	11.3	CCL11, IL5, CRP, CD79A
15	L-Tyrosine²⁵ ¹²	10.3	GOT2, EGFR, GOT1
16	sulfasalazine²⁹ ⁴⁴ ⁵⁰ ¹²	12.3	CRP, IL1RN, CD79A
17	tacrolimus⁴⁴ ⁵⁰ ¹²	11.3	IL5, CCL11, CD79A, GZMB
18	fmlp⁴⁴	9.2	TNFRSF1B, CCL11, IL1RN, IL5
19	rantes⁴⁴	9.2	GZMB, CCL11, TNFRSF1B, IL5, IL1RN
20	polyethylene glycol⁴⁴	9.1	TNFRSF1B, CRP, IL1RN, CD79A
21	etanercept⁴⁴ ⁵⁰ ¹²	11.1	IL1RN, TNFRSF1B, CRP
22	endotoxin⁴⁴	9.1	IL1RN, CCL11, TNFRSF1B, CRP
23	nacl⁴⁴	9.0	FTH1, CCL11, IL1RN, GZMB
24	superoxide⁴⁴ ²⁵	10.0	HRAS, GZMB, IL1RN, CCL11, TNFRSF1B
25	neopterin⁴⁴	9.0	CD79A, GZMB, IL1RN, CRP, TNFRSF1B
26	herbimycin a⁴⁴ ⁶⁰	9.9	IL5, EGFR, HRAS, CCL11
27	p002⁴⁴	8.9	KRAS, IL1RN, TNFRSF1B, CRP
28	vitamin d⁴⁴	8.8	IL5, KRAS, IL1RN, TNFRSF1B, CD79A
29	imatinib⁴⁴ ⁵⁰ ¹²	10.7	KRAS, EGFR, GZMB, IL5
30	heparin⁴⁴ ²⁹ ²⁵ ¹²	11.7	CD79A, IL1RN, CCL11, GZMB, IL5
31	agar⁴⁴	8.7	IL5, NRAS, CD79A, EGFR, HRAS
32	prednisolone⁴⁴ ²⁹ ¹²	10.6	CCL11, CD79A, GZMB, CRP, IL1RN, IL5
33	ivig⁴⁴	8.6	TNFRSF1B, IL5, IL1RN, CD79A, CRP, GZMB
34	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	11.6	TNFRSF1B, FTL, CCL11, IL5, CD79A, GZMB
35	cyclosporin a⁴⁴ ²⁹ ⁶⁰	10.6	CD79A, HRAS, GZMB, IL5, IL1RN, TNFRSF1B
36	methotrexate⁵⁰ ⁴⁴ ¹²	10.5	TNFRSF1B, IL1RN, IL5, CD79A, NLRP3, CRP
37	sb 203580⁴⁴ ⁶⁰	9.3	IL1RN, CRP, EGFR, IL5, CCL11
38	cisplatin⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.3	KRAS, HRAS, GZMB, EGFR, TNFRSF1B
39	rapamycin⁴⁴	8.2	KRAS, GZMB, HRAS, EGFR, CRP
40	oxygen⁴⁴ ²⁵	9.2	IL1RN, KRAS, TNFRSF1B, FTL, FTH1, CCL11
41	paraffin⁴⁴	8.2	KRAS, IL5, GZMB, CD79A, EGFR, HRAS
42	pge2⁴⁴	8.0	IL5, HRAS, EGFR, IL1RN, CD79A, TNFRSF1B
43	h2o2⁴⁴	8.0	HRAS, CD79A, KRAS, TNFRSF1B, FTL, FTH1
44	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	10.9	IL1RN, IL5, EGFR, TNFRSF1B, CD79A, CRP
45	estrogen⁴⁴	7.8	IL1RN, TNFRSF1B, EGFR, HRAS, GZMB, KRAS
46	lipid⁴⁴	7.6	HRAS, KRAS, TNFRSF1B, CRP, GZMB, FTH1
47	ly294002⁴⁴	7.4	CRP, GZMB, HRAS, EGFR, KRAS, IL5
48	tyrosine⁴⁴	7.2	HRAS, KRAS, GZMB, NRAS, EGFR, TNFRSF1B
49	retinoic acid⁴⁴ ²⁵	8.2	TNFRSF1B, CCL11, IL5, IL1RN, GZMB, KRAS
50	vegf⁴⁴	6.6	TNFRSF1B, CCL11, IL5, IL1RN, CRP, GZMB

GO Terms for genes affiliated with Exanthem

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Exanthem according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intracellular ferritin complex	GO:008043	10.0	FTH1, FTL
2	membrane raft	GO:045121	8.5	EGFR, CD79A, KRAS, TNFRSF1B
3	extracellular vesicular exosome	GO:070062	8.3	GOT1, GOT2, FTL, FTH1, IL1RN, NRAS
4	extracellular space	GO:005615	7.9	EGFR, CRP, IL1RN, IL5, CCL11
5	plasma membrane	GO:005886	6.6	GOT2, TNFRSF1B, IL1RN, NRAS, KRAS, CD79A

Biological processes related to Exanthem according to GeneCards/GeneDecks:

(show all 38)

id	Name	GO ID	Score	Top Affiliating Genes
1	iron ion transport	GO:006826	10.2	FTL, FTH1
2	glutamate catabolic process to 2-oxoglutarate	GO:019551	10.1	GOT1, GOT2
3	glutamate catabolic process to aspartate	GO:019550	10.1	GOT1, GOT2
4	response to interleukin-4	GO:070670	10.1	CCL11, IL1RN
5	aspartate biosynthetic process	GO:006532	10.1	GOT1, GOT2
6	aspartate catabolic process	GO:006533	10.1	GOT2, GOT1
7	aspartate metabolic process	GO:006531	10.1	GOT2, GOT1
8	oxaloacetate metabolic process	GO:006107	10.0	GOT1, GOT2
9	glutamate metabolic process	GO:006536	10.0	GOT1, GOT2
10	positive regulation of Rac GTPase activity	GO:032855	9.9	HRAS, CCL11
11	2-oxoglutarate metabolic process	GO:006103	9.7	GOT2, GOT1
12	positive regulation of Rac protein signal transduction	GO:035022	9.7	HRAS, KRAS, NRAS
13	regulation of synaptic transmission, GABAergic	GO:032228	9.7	HRAS, KRAS, NRAS
14	striated muscle cell differentiation	GO:051146	9.7	NRAS, KRAS, HRAS
15	regulation of long-term neuronal synaptic plasticity	GO:048169	9.7	NRAS, KRAS, HRAS
16	visual learning	GO:008542	9.7	NRAS, KRAS, HRAS
17	activation of MAPKK activity	GO:000186	9.7	NRAS, KRAS, HRAS
18	cellular amino acid biosynthetic process	GO:008652	9.6	GOT1, GOT2
19	Ras protein signal transduction	GO:007265	9.6	NRAS, KRAS, HRAS
20	response to glucocorticoid	GO:051384	9.6	KRAS, IL1RN, GOT1
21	leukocyte migration	GO:050900	9.5	HRAS, KRAS, NRAS
22	negative regulation of neuron apoptotic process	GO:043524	9.5	HRAS, KRAS, NRAS
23	GTP catabolic process	GO:006184	9.5	NRAS, KRAS, HRAS
24	actin cytoskeleton organization	GO:030036	9.4	HRAS, KRAS, NRAS
25	immune response	GO:006955	9.2	TNFRSF1B, FTH1, CCL11, IL5, IL1RN
26	positive regulation of cell migration	GO:030335	9.2	HRAS, EGFR, CCL11
27	positive regulation of MAP kinase activity	GO:043406	9.1	KRAS, EGFR, HRAS
28	inflammatory response	GO:006954	9.0	NLRP3, CRP, IL5, CCL11, TNFRSF1B
29	positive regulation of protein phosphorylation	GO:001934	9.0	HRAS, EGFR, KRAS
30	insulin receptor signaling pathway	GO:008286	9.0	HRAS, KRAS, NRAS
31	MAPK cascade	GO:000165	8.9	HRAS, EGFR, KRAS, NRAS
32	fibroblast growth factor receptor signaling pathway	GO:008543	8.9	HRAS, EGFR, KRAS, NRAS
33	Fc-epsilon receptor signaling pathway	GO:038095	8.8	HRAS, EGFR, KRAS, NRAS
34	epidermal growth factor receptor signaling pathway	GO:007173	8.8	HRAS, EGFR, KRAS, NRAS
35	neurotrophin TRK receptor signaling pathway	GO:048011	8.8	HRAS, EGFR, KRAS, NRAS
36	axon guidance	GO:007411	8.8	HRAS, EGFR, KRAS, NRAS
37	positive regulation of cell proliferation	GO:008284	8.6	NRAS, KRAS, EGFR, HRAS
38	innate immune response	GO:045087	8.5	NRAS, NLRP3, KRAS, EGFR, HRAS

Molecular functions related to Exanthem according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	ferric iron binding	GO:008199	9.9	FTH1, FTL
2	L-aspartate:2-oxoglutarate aminotransferase activity	GO:004069	9.7	GOT2, GOT1
3	L-phenylalanine:2-oxoglutarate aminotransferase activity	GO:080130	9.6	GOT2, GOT1
4	protein binding	GO:005515	5.8	TNFRSF1B, FTL, FTH1, CCL11, IL5, CRP

Products for genes affiliated with Exanthem

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Sources for Exanthem

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

RASH MCID: EXN002 MIFTS: 55	Exanthem (RASH) malady Skin diseases category
16 genes, 10 tissues, 200 related diseases, clinical trials Download this MalaCard Expand all tables

Exanthem (RASH) malady