Exfoliation Syndrome disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Exfoliation Syndrome

Sources:
⁴⁶OMIM, ⁶⁴Wikipedia, ³²MalaCards
See all sources

OMIM:⁴⁶ Exfoliation syndrome (XFS) is a common age-related disorder of the extracellular matrix that is frequently associated...177650 more...

MalaCards based summary: Exfoliation Syndrome, also known as pseudoexfoliation glaucoma, is related to primary open angle glaucoma and open-angle glaucoma, and has symptoms including autosomal dominant inheritance, glaucoma and lens subluxation. An important gene associated with Exfoliation Syndrome is LOXL1 (lysyl oxidase-like 1), and among its related pathways are Naphthalene metabolism and Chemical carcinogenesis. The compounds methylchloride and s-phenylmercapturic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related mouse phenotypes are immune system and integument.

Wikipedia:⁶⁴ Pseudoexfoliation syndrome (other names: Exfoliation glaucoma, Pseudoexfoliation glaucoma,... more...

Aliases & Classifications for Exfoliation Syndrome

Sources:
⁹Disease Ontology, ⁴⁶OMIM, ¹¹DISEASES, ⁶¹UMLS, ⁴⁴Novoseek, ¹⁰diseasecard, ⁵⁶SNOMED-CT, ³⁴MeSH, ²⁸ICD9CM
See all sources

Exfoliation Syndrome, Aliases & Descriptions:

Name: Exfoliation Syndrome ⁹ ⁴⁶ ¹¹ ⁶¹

Pseudoexfoliation Glaucoma ⁹ ⁴⁴ ⁶¹

Pseudoexfoliation Syndrome ⁹ ⁴⁴

Exfoliation Syndrome, Susceptibility to ¹⁰

Pseudo-Exfoliation Syndrome ⁶¹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases

External Ids:

Disease Ontology⁹ DOID:13641

OMIM⁴⁶ 177650

SNOMED-CT⁵⁶ 111514006, 44219007

MeSH³⁴ D017889

ICD9CM²⁸ 365.52

UMLS⁶¹ C0206368

Related Diseases for Exfoliation Syndrome

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Exfoliation Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 125)

id	Related Disease	Score	Top Affiliating Genes
1	primary open angle glaucoma	31.0	ELN, GSTM1
2	open-angle glaucoma	30.8	MMP1, LOXL1, ELN, GSTM1, GSTT1
3	cataract	30.6	NUDT6, SOD1, MMP3, CAT, GSTT1
4	aneurysm	30.4	TIMP2, MMP3, ELN
5	abdominal aortic aneurysm	30.3	APOE
6	vascular disease	30.3	TIMP2, MMP3, ELN, CAT
7	pancreatitis	30.2	GSTP1, SOD1, MPO
8	senile cataract	30.1	SOD1, CAT, GSTM1, GSTT1
9	hyperhomocysteinemia	29.9	APOE, SOD1, ELN, MTHFR
10	melanoma	29.7	NUDT6, TIMP2, MMP1, CAT, GSTT1
11	diabetes mellitus	29.2	APOE, SOD1, MMP3, MTHFR, CAT
12	alzheimer's disease	28.9	NUDT6, APOE, SOD1, CHRNA4, CAT, GSTM1
13	rheumatic congestive heart failure	10.5	TIMP2
14	moyamoya disease	10.5	NUDT6
15	aortic disease	10.5	APOE
16	oral submucous fibrosis	10.5	MMP1
17	focal epilepsy	10.5	CHRNA4
18	cerebral aneurysms	10.4	TIMP2, ELN
19	brain cancer	10.4	GSTM1, GSTT1
20	fibromatosis	10.4	TIMP2
21	eclampsia	10.4	MTHFR
22	asbestosis	10.4	GSTM1, GSTT1
23	diabetic cataract	10.4	CAT
24	thoracic aortic aneurysm	10.4	MMP1, ELN
25	lung cancer	10.4	GSTP1, GSTM1
26	epidermolysis bullosa dystrophica	10.4	MMP3, MMP1
27	myelomeningocele	10.3	MTHFR
28	hypertension	10.3
29	retinitis	10.3
30	toxic encephalopathy	10.3	CAT, CHRNA4
31	hypertrophic scars	10.3	ELN, MMP1, NUDT6
32	oral lichen planus	10.3	TIMP2, MMP1
33	acute myeloid leukemia, adult	10.3	GSTM1, GSTT1
34	gingival overgrowth	10.3	MMP1, MMP3, NUDT6
35	pulmonary emphysema	10.3	TIMP2, MMP1, ELN
36	chediak-higashi syndrome	10.3	MPO, LYST
37	keloids	10.3	TIMP2, MMP1, ELN
38	laryngeal benign neoplasm	10.3	GSTT1, GSTP1, GSTM1
39	hypermethioninemia	10.3	SOD1
40	conjunctivochalasis	10.3	MMP1, MMP3, TIMP2
41	myeloperoxidase deficiency	10.3	MPO, CAT
42	nasopharynx carcinoma	10.3	MMP3, GSTM1, GSTT1
43	leukoplakia	10.3	GSTT1, GSTM1
44	homocysteinemia	10.3	MTHFR, ELN
45	bladder carcinoma	10.3	NUDT6, TIMP2, GSTP1
46	ocular hypertension	10.3
47	laryngeal squamous cell carcinoma	10.3	GSTT1, GSTM1, MMP1
48	gastric adenocarcinoma	10.2	GSTT1, GSTM1, TIMP2
49	synovitis	10.2	TIMP2, MMP3, MMP1
50	squamous cell carcinoma of the head and neck	10.2	GSTT1, GSTP1, GSTM1

Graphical network of the top 20 diseases related to Exfoliation Syndrome:

Symptoms for Exfoliation Syndrome

Sources:
⁴⁶OMIM, ⁵⁸The Human Phenotype Ontology
See all sources

Symptoms by clinical synopsis from OMIM:

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Clinical features from OMIM:

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HPO human phenotypes related to Exfoliation Syndrome:

(show all 8)

id	Description	HPO Source Accession
1	autosomal dominant inheritance	HP:0000006
2	glaucoma	HP:0000501
3	lens subluxation	HP:0001132
4	anisocoria	HP:0009916
5	phacodonesis	HP:0012629
6	pigment deposition in the trabecular meshwork	HP:0012631
7	asymmetry of intraocular pressure	HP:0012633
8	retinal vein occlusion	HP:0012636

Drugs & Therapeutics for Exfoliation Syndrome

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Exfoliation Syndrome

Search NIH Clinical Center for Exfoliation Syndrome

Genetic Tests for Exfoliation Syndrome

Anatomical Context for Exfoliation Syndrome

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Exfoliation Syndrome:

³²

Eye, Retina, Endothelial

Animal Models for Exfoliation Syndrome or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Exfoliation Syndrome:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	7.7	MPO, TIMP2, SOD1, MMP3, MMP1, CHRNA4
2	integument phenotype	MP:0010771	7.4	APOE, CHRNA4, LOXL1, LYST, MTHFR, CNTNAP2
3	nervous system phenotype	MP:0003631	6.7	APOE, TIMP2, SOD1, MMP3, CHRNA4, LYST
4	homeostasis/metabolism phenotype	MP:0005376	5.9	GSTT1, APOE, MPO, TIMP2, SOD1, MMP3

Publications for Exfoliation Syndrome

Sources:
⁵¹PubMed
See all sources

Articles related to Exfoliation Syndrome:

(show top 50) (show all 251)

id	Title	Authors	Year
1	Systemic diseases associated with exfoliation syndrome. (25171641)	Bettis D.I.... Wirostko B.M.	2014
2	Oxidative stress in dry age-related macular degeneration and exfoliation syndrome. (25319011)	Chiras D.... Kroupis C.	2014
3	Solar Exposure and Residential Geographic History in Relation to Exfoliation Syndrome in the United States and Israel. (25188364)	Pasquale L.R.... Levkovitch-Verbin H.	2014
4	Circumferential iris transillumination defects in exfoliation syndrome. (22525123)	Fingert J.H.... Anderson M.G.	2013
5	Exfoliation syndrome: new genetic and pathophysiologic insights. (23299249)	Sein J.... Karp C.L.	2013
6	Serum vitamin D deficiency and its association with systemic disease in exfoliation syndrome. (23564611)	Kocabeyoglu S.... Orhan M.	2013
7	Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population. (21738402)	Mayinu .... Chen X.	2011
8	The relationship between diabetes mellitus and exfoliation syndrome in a United States Veterans Affairs population: a case-control study. (20577098)	Wood S.D.... Pasquale L.R.	2011
9	Review: The role of LOXL1 in exfoliation syndrome/glaucoma. (23960948)	Whigham B.T.... Allingham R.R.	2011
10	Association of lysyl oxidase-like 1 gene polymorphisms with exfoliation syndrome in Koreans. (22128228)	Sagong M.... Cha S.C.	2011
11	Prevalence of exfoliation syndrome in Estonia. (20544671)	Kaljurand K.... Teesalu P.	2010
12	Exfoliation syndrome in the Reykjavik Eye Study: risk factors for baseline prevalence and 5-year incidence. (19833615)	Arnarsson A.... Sasaki H.	2010
13	Optic nerve head topography in nonglaucomatous, normotensive patients with unilateral exfoliation syndrome. (19242717)	Puska P.... Harju M.	2009
14	Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma. (20038976)	Tsironi E.E.... Hadjigeorgiou G.M.	2009
15	Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population. (19936304)	Chen L.... Jia H.	2009
16	Biometric characteristics of eyes with exfoliation syndrome and occludable as well as open angles and eyes with primary open-angle glaucoma. (19169317)	Damji K.F.... Hodge W.G.	2009
17	Antioxidant status in the aqueous humour of patients with glaucoma associated with exfoliation syndrome. (19023334)	Ferreira S.M.... Llesuy S.F.	2009
18	Directed Therapy: An Approach to the Improved Treatment of Exfoliation syndrome. (20142958)	Angelilli A.... Ritch R.	2009
19	Prooxidant-antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma. (18607617)	Koliakos G.G.... Konstas A.G.	2008
20	Noncontact in vivo confocal laser scanning microscopy of exfoliation syndrome. (19277220)	Sbeity Z.... Ritch R.	2008
21	Intraocular pressure elevation within the first 24 hours after cataract surgery in patients with glaucoma or exfoliation syndrome. (17561259)	Levkovitch-Verbin H.... Sachs D.	2008
22	Exfoliation syndrome: prevalence and inheritance in a subisolate of the Finnish population. (17655611)	Forsman E.... Forsius H.	2007
23	Effects of APOE and CHRNA4 genotypes on retinal nerve fibre layer thickness at the optic disc and on risk for developing exfoliation syndrome. (17488453)	Ritland J.S.... ElsAYs T.	2007
24	Ultrasound biomicroscopic assessment of zonular appearance in exfoliation syndrome. (17590201)	Ritch R.... Liebmann J.M.	2007
25	Exfoliation syndrome in Nordic countries: a comparative histopathological study of Danish and Finnish eyes with absolute glaucoma and uveal melanoma. (16396649)	Alyahya G.A.... Prause J.U.	2005
26	Endothelin-1 concentration is increased in the aqueous humour of patients with exfoliation syndrome. (15031170)	Koliakos G.G.... Georgiadis N.	2004
27	John G. Lindberg and the discovery of exfoliation syndrome. (11952480)	Tarkkanen A.... KivelAo T.	2002
28	Matrix metalloproteinases and their inhibitors in exfoliation syndrome. (12097800)	Gartaganis S.P.... Vynios D.H.	2002
29	Ascorbic acid concentration is reduced in the aqueous humor of patients with exfoliation syndrome. (12470757)	Koliakos G.G.... Ringvold A.	2002
30	Changes in visual acuity and refraction in the exfoliation syndrome. A five-year follow-up study. (11681503)	Puska P.M.... Tarkkanen A.H.	2001
31	Exfoliation syndrome as a risk factor for cataract development: five-year follow-up of lens opacities in exfoliation syndrome. (11738916)	Puska P.... Tarkkanen A.	2001
32	Electron microscopic study on the development of precapsular layer in eyes with exfoliation syndrome. (10698019)	Zhang X.... Inomata H.	2000
33	Other aspects of exfoliation syndrome. (9292658)	Naumann G.O.	1997
34	Pseudo-exfoliation syndrome in Chivi District: a disease with no geographical or racial boundaries. (9431761)	Masanganise R.	1997
35	Exfoliation syndrome in a 17-year-old girl. (9258230)	Konstas A.G.... Streeten B.W.	1997
36	Interocular differences in optic disc configuration in the unilateral exfoliation syndrome. (8079619)	Tomita G.... Raitta C.	1994
37	Exfoliation syndrome and occludable angles. (7886885)	Ritch R.	1994
38	Exfoliation syndrome and cataract extraction. (8116767)	Moreno-MontaA+Acs J.... Lajara-Blesa J.	1994
39	Climatic droplet keratopathy, exfoliation syndrome, and cataract. (1768663)	Resnikoff S.... Dell'Aquila B.	1991
40	Fibrinoid reaction after extracapsular cataract extraction and relationship to exfoliation syndrome. (2810086)	WAYlinder P.E.... Thorburn W.E.	1989
41	Exfoliation syndrome. Prevalence in a southeastern United States population. (3345150)	Cashwell L.F.... Shields M.B.	1988
42	Prevalence of exfoliation syndrome in Finland. (2853908)	Krause U.... Takala J.	1988
43	Prevalence of exfoliation syndrome in the Japanese. (2853906)	Shimizu K.... Aoki K.	1988
44	The ultrastructural changes in the exfoliation syndrome. (2853916)	Seland J.H.	1988
45	Light microscopy of the exfoliation syndrome. (2853920)	Morrison J.C.... Green W.R.	1988
46	Cataracts in the exfoliation syndrome (fibrillopathia epitheliocapsularis). (6964284)	Seland J.H.... Chylack L.T.	1982
47	On the occurrence of pseudo-exfoliation material in extrabulbar tissue from patients with pseudo-exfoliation syndrome of the eye. (4800604)	Ringvold A.	1973
48	Light and electron microscopy of the anterior iris surface in eyes with and without pseudo-exfoliation syndrome. (4543234)	Ringvold A.	1973
49	Pseudoexfoliation of the lens capsule. II. Development of the exfoliation syndrome. (5819822)	Hansen E.... Sellevold O.J.	1969
50	Exfoliation syndrome. Incidence and prognosis of glaucoma capsulare in Massachusetts. (5928139)	Horven I.	1966

Genes related to Exfoliation Syndrome

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals, ⁴⁶OMIM
See all sources

Genes related to Exfoliation Syndrome:

(show all 19)

- Elite gene

id	Symbol	Description	Score	Implication
1	LOXL1	lysyl oxidase-like 1	20.53	Molecular basis known ⁴⁶ Susceptibility factor ⁴⁶ GeneCards inferred via : Disorders, Publications (show sections)
2	NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	19.45	GeneCards inferred via : Publications (show sections)
3	TMEM9	transmembrane protein 9	18.40	GeneCards inferred via : Disorders (show sections)
4	CHRNA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	17.35	GeneCards inferred via : Publications (show sections)
5	ELN	elastin	16.29	GeneCards inferred via : Publications (show sections)
6	GSTT1	glutathione S-transferase theta 1	15.24	GeneCards inferred via : Publications (show sections)
7	LYST	lysosomal trafficking regulator	14.19	GeneCards inferred via : Publications, Disorders (show sections)
8	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	13.14	GeneCards inferred via : Publications (show sections)
9	TIMP2	TIMP metallopeptidase inhibitor 2	12.08	GeneCards inferred via : Publications (show sections)
10	GSTM1	glutathione S-transferase mu 1	11.03	GeneCards inferred via : Publications (show sections)
11	GSTP1	glutathione S-transferase pi 1	9.98	GeneCards inferred via : Publications (show sections)
12	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	8.93	GeneCards inferred via : Publications (show sections)
13	MPO	myeloperoxidase	7.87	GeneCards inferred via : Publications (show sections)
14	APOE	apolipoprotein E	6.82	GeneCards inferred via : Publications (show sections)
15	CAT	catalase	5.77	GeneCards inferred via : Publications (show sections)
16	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	4.72	GeneCards inferred via : Publications (show sections)
17	SOD1	superoxide dismutase 1, soluble	3.66	GeneCards inferred via : Publications (show sections)
18	CNTNAP2	contactin associated protein-like 2	2.61	GeneCards inferred via : Publications, Disorders (show sections)
19	STMN4	stathmin-like 4	1.56	GeneCards inferred via : Disorders (show sections)

Products for genes related to Exfoliation Syndrome disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	18	-	19	19
2	Novus Biologicals	16	17	19	-

Variations for Exfoliation Syndrome

Sources:
⁷Clinvar
See all sources

Clinvar genetic disease variations for Exfoliation Syndrome:

⁷

id	Gene	Name	Type	Significance	SNP ID	Assembly	Location
1	LTBP2	NM_000428.2(LTBP2): c.1295C> T (p.Pro432Leu)	single nucleotide variant	Likely pathogenic	rs137854861	GRCh37	Chr 14, 75018994: 75018994
2	LTBP2	NM_000428.2(LTBP2): c.1999A> C (p.Ile667Leu)	single nucleotide variant	Likely pathogenic	rs137854859	GRCh37	Chr 14, 74995814: 74995814
3	LTBP2	NM_000428.2(LTBP2): c.4699A> G (p.Met1567Val)	single nucleotide variant	Likely pathogenic	rs137854864	GRCh37	Chr 14, 74970193: 74970193

Expression for genes affiliated with Exfoliation Syndrome

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Exfoliation Syndrome

Search GEO for disease gene expression data for Exfoliation Syndrome.

Pathways for genes affiliated with Exfoliation Syndrome

Sources:
⁴⁹PathCards, ⁵⁹Thomson Reuters, ³⁰KEGG, ⁵⁰PharmGKB, ³⁷NCBI BioSystems Database, ⁵⁴Reactome, ⁵²QIAGEN, ¹³EMD Millipore, ⁵Cell Signaling Technology
See all sources

Pathways related to Exfoliation Syndrome according to GeneCards/GeneDecks:

(show all 14)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Naphthalene metabolism⁵⁹	9.6	GSTT1, GSTP1, GSTM1
2	Chemical carcinogenesis³⁰ Show member pathways Retinol metabolism³⁰ Drug metabolism - cytochrome P450³⁰ Benzo a pyrene metabolism⁵⁹ Artemisinin and Derivatives Pathway, Pharmacokinetics⁵⁰ Aflatoxin B1 metabolism³⁷ Metabolism of xenobiotics by cytochrome P450³⁰ Celecoxib Pathway, Pharmacokinetics⁵⁰ Arylamine metabolism³⁷	9.6	GSTT1, GSTP1, GSTM1
3	Glutathione metabolism³⁰ Show member pathways glutathione-mediated detoxification I³⁷ glutathione redox reactions I³⁷ glutathione redox reactions II³⁷ Glutathione synthesis and recycling⁵⁴ 4-hydroxy-2-nonenal detoxification³⁷ Glutathione conjugation⁵⁴ Glutathione metabolism⁵⁹ Glutathione metabolism³⁷	9.6	GSTM1, GSTP1, GSTT1
4	Matrix Metalloproteinases³⁷ Show member pathways Inhibition of Matrix Metalloproteinases⁵² Activation of Matrix Metalloproteinases⁵⁴	9.6	MMP1, MMP3, TIMP2
5	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics⁵⁰	9.5	GSTT1, GSTP1, MPO
6	superoxide radicals degradation³⁷	9.4	CAT, SOD1
7	Cell adhesion Cell matrix glycoconjugates⁵⁹	9.3	TIMP2, MMP3, MMP1, ELN
8	Cell adhesion ECM remodeling⁵⁹ Show member pathways Metalloproteases in connective tissue degradation¹³	9.3	ELN, MMP1, MMP3, TIMP2
9	Degradation of the extracellular matrix⁵⁴ Show member pathways Collagen degradation⁵⁴ Extracellular matrix organization⁵⁴	9.2	TIMP2, MMP3, MMP1, LOXL1, ELN
10	Detoxification of Reactive Oxygen Species⁵⁴ Show member pathways Oxidative Stress Regulatory Pathway (Erythrocyte)⁵⁰	9.1	SOD1, CAT, GSTP1
11	Platinum Pathway, Pharmacokinetics/Pharmacodynamics⁵⁰	8.6	GSTT1, GSTP1, GSTM1, SOD1, MPO
12	Selenium Pathway³⁷ Show member pathways thioredoxin pathway³⁷	8.5	MPO, SOD1, MTHFR, CAT
13	Neuroscience⁵	8.3	APOE, SOD1, CNTNAP2, GSTP1
14	Folate Metabolism³⁷ Show member pathways Vitamin B12 Metabolism³⁷	8.1	APOE, MPO, SOD1, MTHFR, CAT

Compounds for genes affiliated with Exfoliation Syndrome

Sources:
⁴⁴Novoseek, ¹²DrugBank, ²⁵HMDB, ⁵⁰PharmGKB, ²⁹IUPHAR, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Exfoliation Syndrome according to GeneCards/GeneDecks:

(show top 50) (show all 248)

id	Compound	Score	Top Affiliating Genes
1	methylchloride⁴⁴	10.0	GSTT1, GSTP1, GSTM1
2	s-phenylmercapturic acid⁴⁴	9.9	GSTP1, GSTM1, GSTT1
3	cumene hydroperoxide⁴⁴	9.8	GSTT1, GSTP1, GSTM1
4	(4-aminophenyl)mercuric acetate⁴⁴	9.8	TIMP2, ELN, MMP1, MMP3
5	1,3-butadiene⁴⁴	9.7	GSTP1, GSTM1, GSTT1
6	latanoprost⁴⁴ ¹²	10.6	MMP1, MMP3, TIMP2
7	chi 2⁴⁴	9.5	GSTT1, TIMP2, GSTM1, MTHFR
8	doxycycline⁴⁴ ¹²	10.5	GSTP1, ELN, MMP1, NUDT6, MMP3
9	adrenochrome⁴⁴ ²⁵	10.4	GSTT1, GSTP1, GSTM1, SOD1
10	n-(2-mercaptopropionyl)glycine⁴⁴	9.3	SOD1, MPO, CAT
11	gsts⁴⁴	9.3	MTHFR, GSTM1, GSTP1, GSTT1
12	oxypurinol⁴⁴	9.3	SOD1, MPO, CAT
13	8-oxo-dg⁴⁴	9.2	GSTM1, SOD1, CAT, GSTT1
14	glutathion⁴⁴	9.2	CAT, SOD1, GSTM1, GSTP1
15	p002⁴⁴	9.1	GSTM1, MTHFR, MMP3, TIMP2, GSTT1
16	hyaluronic acid⁴⁴ ²⁵	10.1	MMP3, TIMP2, ELN, MMP1, APOE
17	sodium azide⁴⁴	9.1	SOD1, CAT, MMP1, MPO
18	gssg⁴⁴	9.1	GSTP1, SOD1, CAT, GSTM1
19	formate⁴⁴	9.0	APOE, SOD1, ELN, CAT
20	pravastatin⁴⁴ ⁵⁰ ²⁹ ²⁵ ¹²	13.0	MMP1, APOE, TIMP2, MMP3, MTHFR
21	manganese superoxide⁴⁴	8.9	SOD1, CAT, GSTM1, GSTT1, GSTP1
22	formaldehyde⁴⁴ ²⁵	9.9	MPO, GSTT1, CAT, ELN, MMP1
23	malondialdehyde⁴⁴	8.9	SOD1, CAT, GSTM1, MPO, GSTT1
24	methotrexate⁵⁰ ⁴⁴ ¹²	10.8	TIMP2, GSTP1, GSTM1, MTHFR, MMP3, MMP1
25	guaiacol⁴⁴ ²⁵	9.7	MPO, SOD1, CAT
26	cyclophosphamide⁴⁴ ⁵⁰ ¹²	10.7	MPO, GSTT1, MTHFR, GSTM1, GSTP1
27	paraffin⁴⁴	8.6	ELN, MMP1, GSTP1, TIMP2, MPO, APOE
28	egcg⁴⁴	8.6	MMP3, TIMP2, SOD1, MMP1, CAT, GSTP1
29	folate⁴⁴	8.6	GSTM1, MTHFR, APOE, GSTT1, GSTP1
30	oxaliplatin⁴⁴ ⁵⁰ ¹²	10.5	GSTT1, GSTP1, MPO, SOD1, MTHFR, GSTM1
31	carboplatin⁴⁴ ⁵⁰ ¹²	10.5	MPO, SOD1, MTHFR, GSTM1, GSTP1, GSTT1
32	valine⁴⁴	8.5	MPO, GSTP1, ELN, MTHFR, GSTT1, GSTM1
33	vitamin a⁴⁴ ²⁵ ¹²	10.5	SOD1, APOE, MMP1, GSTM1, ELN, CAT
34	dmso⁴⁴	8.4	SOD1, MPO, GSTP1, MMP3, NUDT6, CAT
35	vegf⁴⁴	8.4	MMP1, MPO, APOE, MMP3, NUDT6, ELN
36	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	11.3	GSTP1, GSTM1, MTHFR, MMP1, APOE, NUDT6
37	alpha tocopherol⁴⁴	8.2	MMP1, SOD1, MTHFR, CAT, APOE, GSTM1
38	arginine⁴⁴	8.2	ELN, SOD1, APOE, NUDT6, GSTP1, GSTT1
39	indomethacin⁴⁴ ²⁹ ⁶⁰ ¹²	11.2	CAT, APOE, MPO, SOD1, MMP3, MMP1
40	retinoic acid⁴⁴ ²⁵	9.2	MPO, ELN, MTHFR, TIMP2, MMP3, MMP1
41	4-hydroxynonenal⁴⁴ ²⁵	9.1	MMP1, MPO, SOD1, CAT, GSTM1, GSTP1
42	betacarotene⁴⁴	8.0	MMP1, APOE, SOD1, ELN, MTHFR, GSTM1
43	estrogen⁴⁴	8.0	MTHFR, GSTM1, ELN, MMP1, GSTT1, GSTP1
44	n acetylcysteine⁴⁴	7.9	CAT, APOE, MMP1, MMP3, SOD1, ELN
45	serine⁴⁴	7.6	NUDT6, APOE, MPO, TIMP2, MMP1, CHRNA4
46	h2o2⁴⁴	7.6	ELN, MMP1, APOE, SOD1, TIMP2, CAT
47	lactate⁴⁴	7.5	CAT, ELN, MMP1, MMP3, SOD1, TIMP2
48	creatinine⁴⁴	7.0	GSTM1, GSTP1, SOD1, APOE, MPO, GSTT1
49	cysteine⁴⁴	7.0	TIMP2, NUDT6, APOE, SOD1, MMP3, MMP1
50	ascorbic acid⁴⁴ ²⁵	7.6	SOD1, TIMP2, MPO, APOE, MMP1, MMP3

GO Terms for genes affiliated with Exfoliation Syndrome

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Exfoliation Syndrome according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	9.1	MMP3, MMP1, LOXL1, ELN
2	extracellular region	GO:005576	8.1	TIMP2, SOD1, MMP3, MMP1, LOXL1, ELN
3	neuronal cell body	GO:043025	8.1	CNTNAP2, CHRNA4, SOD1, TIMP2, APOE
4	extracellular space	GO:005615	7.9	APOE, MPO, TIMP2, SOD1, MMP3, LOXL1

Biological processes related to Exfoliation Syndrome according to GeneCards/GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	synaptic transmission, cholinergic	GO:007271	10.0	APOE, CHRNA4
2	low-density lipoprotein particle remodeling	GO:034374	9.9	MPO, APOE
3	glutathione derivative biosynthetic process	GO:1901687	9.9	GSTT1, GSTP1, GSTM1
4	xenobiotic metabolic process	GO:006805	9.8	GSTM1, GSTT1
5	positive regulation of superoxide anion generation	GO:032930	9.8	SOD1, GSTP1
6	removal of superoxide radicals	GO:019430	9.7	SOD1, MPO
7	negative regulation of cholesterol biosynthetic process	GO:045541	9.7	SOD1, APOE
8	oxidation-reduction process	GO:055114	9.7	GSTT1, LOXL1, MPO
9	extracellular matrix disassembly	GO:022617	9.6	TIMP2, MMP3, MMP1, ELN
10	response to reactive oxygen species	GO:000302	9.6	GSTP1, CAT, APOE
11	aging	GO:007568	9.6	APOE, MPO, TIMP2
12	extracellular matrix organization	GO:030198	9.4	TIMP2, MMP3, MMP1, LOXL1, ELN
13	hydrogen peroxide catabolic process	GO:042744	9.3	CAT, MPO
14	glutathione metabolic process	GO:006749	9.3	GSTT1, GSTP1, GSTM1, SOD1
15	response to hypoxia	GO:001666	9.3	CAT, MTHFR, CHRNA4
16	transmission of nerve impulse	GO:019226	9.1	CNTNAP2, SOD1
17	response to drug	GO:042493	8.9	TIMP2, SOD1, LYST, MTHFR, GSTT1
18	small molecule metabolic process	GO:044281	8.4	GSTT1, GSTP1, GSTM1, CAT, MTHFR, APOE

Molecular functions related to Exfoliation Syndrome according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	antioxidant activity	GO:016209	9.6	CAT, APOE
2	glutathione transferase activity	GO:004364	9.3	GSTT1, GSTP1, GSTM1

Products for genes affiliated with Exfoliation Syndrome

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Exfoliation Syndrome

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

MCID: EXF001 MIFTS: 59	Exfoliation Syndrome malady Eye diseases category
8 symptoms, 19 genes, 3 tissues, 125 related diseases, clinical trials Download this MalaCard Expand all tables

Exfoliation Syndrome malady