Exfoliation Syndrome disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Exfoliation Syndrome

Sources:
⁶³Wikipedia, ⁴⁶OMIM, ³²MalaCards
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Wikipedia:⁶³ Pseudoexfoliation syndrome, (other names: Exfoliation glaucoma, Pseudoexfoliation glaucoma,... more...

MalaCards: Exfoliation Syndrome, also known as pseudoexfoliation glaucoma, is related to glaucoma and cataract. An important gene associated with Exfoliation Syndrome is LOXL1 (lysyl oxidase-like 1), and among its related pathways are Crosslinking of collagen fibrils and Aflatoxin B1 metabolism. The compounds estrogen and bpde have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:⁴⁶ 177650

Aliases & Classifications for Exfoliation Syndrome

Sources:
⁸Disease Ontology, ⁹diseasecard, ⁴⁶OMIM, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ³⁴MeSH, ⁵⁶SNOMED-CT, ²⁷ICD9CM
See all sources

Aliases & Descriptions:

exfoliation syndrome ⁸ ⁴⁶ ¹⁰ ⁶⁰

pseudoexfoliation glaucoma ⁸ ⁴⁴

pseudoexfoliation syndrome ⁸ ⁴⁴

exfoliation syndrome, susceptibility to ⁹

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Disease Ontology⁸ DOID:13641

MeSH³⁴ D017889

SNOMED-CT⁵⁶ 111514006, 44219007

OMIM⁴⁶ 177650

ICD9CM²⁷ 365.52

UMLS⁶⁰ C0206368

Related Diseases for Exfoliation Syndrome

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases related to Exfoliation Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 129)

id	Related Disease	Score	Top Affiliating Genes
1	glaucoma	31.1	LOXL1, TIMP2, NUDT6, GSTP1, ELN
2	cataract	30.8	GSTT1, NUDT6, CAT
3	open-angle glaucoma	30.5	LOXL1, GSTM1, GSTT1, ELN
4	hypertension	30.4	APOE
5	primary open angle glaucoma	30.3	ELN, GSTM1
6	senile cataract	30.2	CAT, GSTM1, GSTT1
7	pancreatitis	30.2	MPO, GSTP1
8	hyperhomocysteinemia	30.2	ELN, APOE
9	vascular disease	30.0	LOX, TIMP2, CAT, APOE, ELN
10	abdominal aortic aneurysm	29.8	APOE
11	diabetes mellitus	29.8	APOE, CAT
12	melanoma	29.8	LOX, TIMP2, CAT, NUDT6, GSTT1
13	alzheimer's disease	29.8	LOX, CAT, APOE, CHRNA4, NUDT6, GSTM1
14	retinitis	10.3
15	ocular hypertension	10.2
16	retinoschisis	10.1
17	sensorineural hearing loss	10.1
18	lattice corneal dystrophy	10.0
19	bullous keratopathy	10.0
20	mature cataract	10.0
21	astigmatism	10.0
22	corneal dystrophy	10.0
23	motor neuron disease	10.0	GSTT1
24	ehlers-danlos syndrome	10.0	ELN
25	astrocytoma	10.0	GSTT1
26	psoriasis	10.0	LOX
27	liver cirrhosis	10.0	LOX
28	proliferative diabetic retinopathy	10.0	TIMP2
29	acute pancreatitis	10.0	MPO
30	age related macular degeneration	10.0	APOE
31	cleft palate	10.0	GSTM1
32	inflammatory bowel disease	10.0	MPO
33	esophageal cancer	10.0	GSTP1
34	cleft lip	10.0	GSTM1
35	nephrotic syndrome	10.0	APOE
36	down syndrome	10.0	APOE
37	oral submucous fibrosis	10.0	LOX
38	pituitary tumors	10.0	NUDT6
39	occipital horn syndrome	10.0	LOX
40	graves' disease	10.0	MPO
41	peritonitis	10.0	MPO
42	osteomalacia	10.0	PHEX
43	esophagitis	10.0	CAT
44	galactosemia	10.0	CAT
45	vitiligo	10.0	CAT
46	familial adenomatous polyposis	10.0	GSTP1
47	hepatitis c	10.0	GSTM1
48	amyotrophic lateral sclerosis	10.0	NUDT6, LOX
49	gastritis	10.0	CAT
50	hellp syndrome	10.0	GSTP1

Graphical network of the top 20 diseases related to Exfoliation Syndrome:

Clinical Features for Exfoliation Syndrome

Sources:
⁴⁶OMIM
See all sources

Clinical features from OMIM:

177650

Clinical synopsis from OMIM:

177650

Drugs & Therapeutics for Exfoliation Syndrome

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Exfoliation Syndrome

Drug clinical trials:

Search ClinicalTrials for Exfoliation Syndrome

Search NIH Clinical Center for Exfoliation Syndrome

Search CenterWatch for Exfoliation Syndrome

Genetic Tests for Exfoliation Syndrome

Anatomical Context for Exfoliation Syndrome

Sources:
³²MalaCards
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MalaCards organs/tissues related to Exfoliation Syndrome:

³²

Eye, Skin, Retina, Lung, Endothelial

Animal Models for Exfoliation Syndrome or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Exfoliation Syndrome:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	9.0	ELN, GSTT1, LYST, CHRNA4, PHEX, APOE

Publications for Exfoliation Syndrome

Sources:
⁵⁰PubMed
See all sources

Articles related to Exfoliation Syndrome:

(show top 50) (show all 256)

id	Title	Authors	Year
1	Circumferential iris transillumination defects in exfoliation syndrome. (22525123)	Fingert J.H.... Anderson M.G.	2013
2	Prevalence of high-risk alleles in the LOXL1 gene and its association with pseudoexfoliation syndrome and exfoliation glaucoma in a Latin American population. (21970694)	Jaimes M.... Zenteno J.C.	2012
3	LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population. (21212179)	Fan B.J.... Wiggs J.L.	2011
4	Prevalence of exfoliation syndrome in Estonia. (20544671)	Kaljurand K.... Teesalu P.	2010
5	Exfoliation syndrome in the Reykjavik Eye Study: risk factors for baseline prevalence and 5-year incidence. (19833615)	Arnarsson A.... Sasaki H.	2010
6	Scanning laser ophthalmoscopic parameters of eyes with exfoliation syndrome. (20700797)	Cankaya A.B.... Beyazyildiz E.	2010
7	Retinal vascular occlusions occur more frequently in the more affected eye in exfoliation syndrome. (19557023)	Prata T.S.... Ritch R.	2010
8	Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population. (19936304)	Chen L.... Jia H.	2009
9	Directed Therapy: An Approach to the Improved Treatment of Exfoliation syndrome. (20142958)	Angelilli A.... Ritch R.	2009
10	Epidemiology of exfoliation syndrome in the Reykjavik Eye Study. (20017735)	Arnarsson A.M.	2009
11	Exfoliation syndrome: effects of cataract surgery on glaucoma. (19006713)	Mamalis N.	2008
12	Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome. (18636115)	Mabuchi F.... Tsukahara S.	2008
13	Exfoliation syndrome: prevalence and inheritance in a subisolate of the Finnish population. (17655611)	Forsman E.... Forsius H.	2007
14	Effects of APOE and CHRNA4 genotypes on retinal nerve fibre layer thickness at the optic disc and on risk for developing exfoliation syndrome. (17488453)	Ritland J.S.... ElsAYs T.	2007
15	Topical latanoprost causes posterior movement of lens in a patient with exfoliation syndrome and subluxated lens: a case report. (18053229)	Kanamoto T.... Kiuchi Y.	2007
16	Exfoliation syndrome as a risk factor for corneal endothelial cell loss in cataract surgery. (18025655)	Kaljurand K.... Teesalu P.	2007
17	Current concepts in the pathogenesis and management of exfoliation syndrome and exfoliative glaucoma. (16882401)	Konstas A.G.... Ritch R.	2006
18	Exfoliation syndrome among Azerbaijani. (12796278)	Gasch A.T.... Seidova S.	2003
19	Unilateral exfoliation syndrome: conversion to bilateral exfoliation and to glaucoma: a prospective 10-year follow-up study. (12483098)	Puska P.M.	2002
20	Evaluation of the clinical association between exfoliation syndrome and abdominal aortic aneurysm. (12485282)	Hietanen J.... Tarkkanen A.	2002
21	Exfoliation syndrome. (11224719)	Ritch R.	2001
22	Perspective on exfoliation syndrome. (11890270)	Ritch R.	2001
23	Increased aqueous humor basic fibroblast growth factor and hyaluronan levels in relation to the exfoliation syndrome and exfoliative glaucoma. (11782221)	Gartaganis S.P.... Karamanos N.K.	2001
24	Exfoliation syndrome and exfoliation glaucoma. (10749381)	Vesti E.... KivelAo T.	2000
25	Optic disc changes in normotensive persons with unilateral exfoliation syndrome: a 3-year follow-up study. (10379604)	Puska P.... Raitta C.	1999
26	Autopsy analysis of clinically unilateral exfoliation syndrome. (9331264)	KivelAo T.... Uusitalo M.	1997
27	Hyaluronan in the exfoliation syndrome. (9253969)	Fitzsimmons T.D.... Wallin O.	1997
28	Histopathological and lectin histochemical study of exfoliation syndrome. (8883563)	Hietanen J.	1996
29	The amount of lens exfoliation and chamber-angle pigmentation in exfoliation syndrome with or without glaucoma. (7493233)	Puska P.	1995
30	Lectin and immunohistochemical comparison of glycoconjugates in the conjunctiva of patients with and without exfoliation syndrome. (7542024)	Hietanen J.... KivelAo T.	1995
31	The impact of exfoliation syndrome on therapeutic efficacy in open-angle glaucoma. (10150850)	Tarkkanen A.... Hietanen J.	1995
32	Interocular differences in optic disc configuration in the unilateral exfoliation syndrome. (8079619)	Tomita G.... Raitta C.	1994
33	Incidence of posterior capsule opacification in eyes with exfoliation syndrome and heparin-surface-modified intraocular lenses. (8501628)	ZetterstrAPm C.	1993
34	Aqueous dynamics in exfoliation syndrome. (1415459)	Gharagozloo N.Z.... Brubaker R.F.	1992
35	Exfoliation syndrome in patients scheduled for cataract surgery. (1414287)	Hietanen J.... Tarkkanen A.	1992
36	Climatic droplet keratopathy, exfoliation syndrome, and cataract. (1768663)	Resnikoff S.... Dell'Aquila B.	1991
37	Nanophthalmos in sisters, one with exfoliation syndrome. (2696577)	Diehl D.L.... Shea M.	1989
38	Glycoconjugates in exfoliation syndrome. A lectin histochemical study of the ciliary body and lens. (2763817)	Hietanen J.... Tarkkanen A.	1989
39	Prevalence of exfoliation syndrome in Finland. (2853908)	Krause U.... Takala J.	1988
40	Light microscopy of the exfoliation syndrome. (2853920)	Morrison J.C.... Green W.R.	1988
41	Exfoliation syndrome. Sigrid Juselius Foundation international workshop. 29 September-2 October, 1987, Espoo, Finland. Proceedings. (2853903)		1988
42	The relationship between the fluoroangiographic aspect of the optic disk and the visual field in patients with the exfoliation syndrome with and without intraocular hypertension. Part I: Bilateral cases. (2853923)	Cambiaggi A.... Marras A.	1988
43	The initial stage of the exfoliation syndrome. (3002107)	Jerndal T.	1985
44	Evidence for chromosome instability in vivo in Bloom syndrome: increased numbers of micronuclei in exfoliated cells. (4065890)	Rosin M.P.... German J.	1985
45	Laser trabeculoplasty in the pseudo-exfoliation syndrome. (6592860)	Logan P.... Eustace P.	1983
46	The trabecular meshwork of a non-glaucomatous eye with the exfoliation syndrome. Electronmicroscopic study. (160125)	Benedikt O.... Roll P.	1979
47	Exfoliation syndrome. (4421811)	Layden W.E.... Shaffer R.N.	1974
48	Light and electron microscopy of the wall of iris vessels in eyes with and without exfoliation syndrome (pseudoexfoliation of the lens capsule). (5309200)	Ringvold A.	1970
49	Lyell's disease, the Stevens-Johnson Syndrome, and exfoliative dermatitis. (4250164)	Ostler H.B.... Groundwater J.	1970
50	Four hereditary mucosal syndromes: comparative histology and exfoliative cytology of Darier-White's disease, hereditary benign intraepithelial dyskeratosis, white sponge nevus, and pachyonychia congenita. (14007732)	Witkop C.J.... Gorlin R.J.	1961

Genes related to Exfoliation Syndrome

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc., ⁴⁶OMIM
See all sources

Genes related to Exfoliation Syndrome:

(show all 26)

id	Symbol	Description	Score	Implication
1	LOXL1	lysyl oxidase-like 1	20.38	Molecular basis known ⁴⁶ Susceptibility factor ⁴⁶ GeneCards inferred : Publications, Disorders (show sections)
2	NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	19.60	GeneCards inferred : Publications, Disorders (show sections)
3	CHRNA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	18.83	GeneCards inferred : Publications, Disorders (show sections)
4	TMEM9	transmembrane protein 9	18.06	GeneCards inferred : Disorders (show sections)
5	GSTT1	glutathione S-transferase theta 1	17.29	GeneCards inferred : Publications, Disorders (show sections)
6	TIMP2	TIMP metallopeptidase inhibitor 2	16.52	GeneCards inferred : Publications, Disorders (show sections)
7	ELN	elastin	15.75	GeneCards inferred : Publications, Disorders (show sections)
8	LOX	lysyl oxidase	14.98	GeneCards inferred : Disorders (show sections)
9	GSTP1	glutathione S-transferase pi 1	14.21	GeneCards inferred : Publications, Disorders (show sections)
10	GSTM1	glutathione S-transferase mu 1	13.44	GeneCards inferred : Publications, Disorders (show sections)
11	MPO	myeloperoxidase	12.67	GeneCards inferred : Publications, Disorders (show sections)
12	LYST	lysosomal trafficking regulator	11.90	GeneCards inferred : Publications, Disorders (show sections)
13	APOE	apolipoprotein E	11.13	GeneCards inferred : Publications, Disorders (show sections)
14	AKAP2	A kinase (PRKA) anchor protein 2	10.37	GeneCards inferred : Disorders (show sections)
15	PHEX	phosphate regulating endopeptidase homolog, X-linked	9.60	GeneCards inferred : Disorders (show sections)
16	CAT	catalase	8.83	GeneCards inferred : Publications, Disorders (show sections)
17	STMN4	stathmin-like 4	8.06	GeneCards inferred : Disorders (show sections)
18	LRRC4B	leucine rich repeat containing 4B	7.29	GeneCards inferred : Disorders (show sections)
19	MGST1	microsomal glutathione S-transferase 1	6.52	GeneCards inferred : Disorders (show sections)
20	CTNNBL1	catenin, beta like 1	5.75	GeneCards inferred : Disorders (show sections)
21	SOD1	superoxide dismutase 1, soluble	4.98	GeneCards inferred : Publications, Disorders (show sections)
22	LTBP1	latent transforming growth factor beta binding protein 1	4.21	GeneCards inferred : Disorders (show sections)
23	CNTNAP2	contactin associated protein-like 2	3.44	GeneCards inferred : Publications, Disorders (show sections)
24	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	2.28	GeneCards inferred : Publications (show sections)
25	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	1.50	GeneCards inferred : Publications (show sections)
26	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	0.72	GeneCards inferred : Publications (show sections)

Products for genes related to Exfoliation Syndrome disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	25	25	25
2	LSBio	-	-	26

Genetic Variations for Exfoliation Syndrome

Expression for genes affiliated with Exfoliation Syndrome

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Exfoliation Syndrome

Search GEO for disease gene expression data for Exfoliation Syndrome.

Pathways for genes affiliated with Exfoliation Syndrome

Sources:
⁵³Reactome, ³⁷NCBI BioSystems Database, ¹²EMD Millipore, ⁴⁹PharmGKB, ²⁹KEGG
See all sources

Pathways related to Exfoliation Syndrome according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Crosslinking of collagen fibrils⁵³	10.1	LOX, LOXL1
2	Aflatoxin B1 metabolism³⁷	10.1	GSTM1, GSTT1
3	Elastic fibre formation⁵³ Hide members Molecules associated with elastic fibres⁵³	9.9	ELN, LOX, LOXL1
4	Naphthalene metabolism Hide members Naphthalene metabolism¹²	9.9	GSTP1, GSTT1, GSTM1
5	Etoposide Pathway, Pharmacokinetics/Pharmacodynamics⁴⁹	9.9	MPO, GSTT1, GSTP1
6	Platinum Pathway, Pharmacokinetics/Pharmacodynamics⁴⁹	9.7	GSTP1, GSTT1, GSTM1, MPO
7	Drug metabolism - cytochrome P450²⁹ Hide members Chemical carcinogenesis²⁹ Metabolism of xenobiotics by cytochrome P450²⁹	9.5	MGST1, GSTM1, GSTT1, GSTP1
8	Glutathione metabolism Hide members Glutathione conjugation⁵³ Glutathione metabolism¹² Glutathione metabolism²⁹ glutathione-mediated detoxification I³⁷ Glutathione metabolism³⁷	9.5	GSTP1, GSTT1, GSTM1, MGST1
9	Biological oxidations⁵³ Hide members Phase II conjugation⁵³ metapathway biotransformation³⁷	9.5	GSTP1, GSTT1, GSTM1, MGST1

Compounds for genes affiliated with Exfoliation Syndrome

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ⁵⁹Tocris Bioscience, ²⁸IUPHAR, ⁴⁹PharmGKB, ²⁴HMDB
See all sources

Compounds related to Exfoliation Syndrome according to GeneCards/GeneDecks:

(show top 50) (show all 111)

id	Compound	Score	Top Affiliating Genes
1	estrogen⁴⁴	10.7	ELN
2	bpde⁴⁴	10.5	GSTP1
3	alpha tocopherol⁴⁴	10.4	GSTM1
4	methylchloride⁴⁴	10.3	GSTT1, GSTM1, GSTP1
5	s-phenylmercapturic acid⁴⁴	10.3	GSTT1, GSTM1, GSTP1
6	cumene hydroperoxide⁴⁴	10.3	GSTP1, GSTT1, GSTM1
7	1,3-butadiene⁴⁴	10.3	GSTM1, GSTT1, GSTP1
8	bleomycin⁴⁴ ¹¹	11.3	LOX, APOE, ELN
9	indomethacin⁴⁴ ⁵⁹ ²⁸ ¹¹	13.3	ELN, LOX
10	styrene⁴⁴	10.2	GSTM1, GSTP1, GSTT1
11	1-hydroxypyrene⁴⁴	10.2	GSTM1, GSTT1, GSTP1
12	suramin⁴⁴ ²⁸ ¹¹	12.2	NUDT6, APOE
13	trichloroethylene⁴⁴	10.2	GSTM1, GSTT1, GSTP1
14	chi 2⁴⁴	10.2	GSTM1, GSTT1, TIMP2
15	chlorambucil⁴⁴ ¹¹	11.2	MGST1, GSTP1
16	glutathion⁴⁴	10.2	CAT, GSTM1, GSTP1
17	(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene¹¹	10.1	GSTP1, GSTM1
18	oxaliplatin⁴⁴ ⁴⁹ ¹¹	12.0	GSTP1, GSTM1, MPO, GSTT1
19	d penicillamine⁴⁴	10.0	CAT, MPO, LOX, ELN
20	8-oxo-dg⁴⁴	10.0	CAT, GSTT1, GSTM1
21	cysteamine⁴⁴ ¹¹ ²⁴	12.0	CAT, APOE, MPO
22	isoniazid⁴⁹ ⁴⁴ ¹¹	12.0	CAT, GSTT1, GSTM1
23	quinone⁴⁴ ²⁴	11.0	GSTT1, CAT, LOX, GSTM1
24	1-chloro-24-dinitrobenzene⁴⁴	10.0	GSTT1, GSTP1, GSTM1, MGST1
25	noradrenochrome⁴⁴ ²⁴	11.0	GSTM1, MGST1, GSTT1, GSTP1
26	hydrochloric acid⁴⁴ ²⁴	11.0	GSTT1, GSTM1, MGST1, GSTP1
27	adrenochrome⁴⁴ ²⁴	11.0	GSTP1, MGST1, GSTM1, GSTT1
28	benzene⁴⁴	10.0	GSTT1, ELN, GSTM1
29	carboplatin⁴⁴ ⁴⁹ ¹¹	12.0	GSTP1, GSTT1, GSTM1, MPO
30	gsts⁴⁴	9.9	GSTP1, GSTT1, GSTM1, MGST1
31	Glutathione¹¹ ²⁴	10.9	GSTM1, MGST1, GSTP1, GSTT1
32	manganese superoxide⁴⁴	9.9	CAT, GSTP1, GSTT1, GSTM1
33	epoxide⁴⁴	9.9	GSTM1, GSTP1, MGST1, GSTT1
34	malondialdehyde⁴⁴	9.9	GSTT1, GSTM1, MPO, CAT
35	acetone⁴⁴	9.9	GSTM1, GSTT1, GSTP1
36	betacarotene⁴⁴	9.9	CAT, ELN, APOE, GSTM1
37	4-aminobenzoic acid hydrazide⁴⁴	9.9	CAT, MPO
38	dmso⁴⁴	9.8	CAT, MPO, NUDT6, GSTP1, ELN
39	dcnb⁴⁴	9.8	GSTP1, GSTM1
40	4-hydroxynonenal⁴⁴ ²⁴	10.7	GSTP1, GSTM1, MPO, APOE, CAT
41	paraffin⁴⁴	9.6	LOX, TIMP2, APOE, MPO, ELN, GSTP1
42	n acetylcysteine⁴⁴	9.6	ELN, GSTP1, MPO, APOE, CAT, LOX
43	h2o2⁴⁴	9.5	LOX, MPO, CAT, ELN, MGST1, TIMP2
44	valine⁴⁴	9.5	APOE, ELN, MPO, GSTM1, GSTT1, GSTP1
45	creatinine⁴⁴	9.5	APOE, GSTM1, ELN, TIMP2, GSTT1, MPO
46	lactate⁴⁴	9.3	CAT, TIMP2, GSTP1, ELN, GSTM1, MPO
47	vegf⁴⁴	9.2	TIMP2, APOE, MGST1, LOX, NUDT6, GSTP1
48	arginine⁴⁴	9.1	ELN, MGST1, GSTP1, APOE, GSTT1, GSTM1
49	ascorbic acid⁴⁴ ²⁴	10.0	GSTM1, ELN, GSTP1, GSTT1, MPO, APOE
50	cysteine⁴⁴	8.9	ELN, GSTP1, GSTM1, MGST1, APOE, CAT

GO Terms for genes affiliated with Exfoliation Syndrome

Sources:
¹⁶Gene Ontology
See all sources

Biological processes related to Exfoliation Syndrome according to GeneCards/GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	low-density lipoprotein particle remodeling	GO:034374	10.0	MPO, APOE
2	response to reactive oxygen species	GO:000302	9.9	GSTP1, APOE, CAT
3	synaptic transmission, cholinergic	GO:007271	9.8	CHRNA4, APOE
4	oxidation-reduction process	GO:055114	9.8	MPO, MGST1, LOXL1
5	glutathione derivative biosynthetic process	GO:1901687	9.7	GSTP1, GSTT1, GSTM1, MGST1
6	glutathione metabolic process	GO:006749	9.7	MGST1, GSTM1, GSTT1, GSTP1
7	extracellular matrix organization	GO:030198	9.7	LOXL1, LOX, TIMP2, ELN
8	xenobiotic metabolic process	GO:006805	9.6	MGST1, GSTM1, GSTT1, GSTP1
9	response to drug	GO:042493	9.5	LOX, TIMP2, MGST1, LYST, GSTT1

Molecular functions related to Exfoliation Syndrome according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	glutathione binding	GO:043295	9.6	MGST1, GSTM1
2	glutathione transferase activity	GO:004364	9.4	GSTP1, GSTT1, GSTM1, MGST1
3	enzyme binding	GO:019899	9.4	GSTM1, AKAP2, CTNNBL1, CAT