MCID: EXF001
MIFTS: 51

Exfoliation Syndrome malady

Summaries for Exfoliation Syndrome

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Pseudoexfoliation syndrome, (other names: Exfoliation glaucoma, Pseudoexfoliation glaucoma,... more...

MalaCards: Exfoliation Syndrome, also known as pseudoexfoliation glaucoma, is related to glaucoma and cataract. An important gene associated with Exfoliation Syndrome is LOXL1 (lysyl oxidase-like 1), and among its related pathways are Crosslinking of collagen fibrils and Aflatoxin B1 metabolism. The compounds estrogen and bpde have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and retina, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:46 177650

Aliases & Classifications for Exfoliation Syndrome

About this section
Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 60UMLS, 44Novoseek, 9diseasecard, 34MeSH, 56SNOMED-CT, 27ICD9CM
See all sources

Aliases & Descriptions:

exfoliation syndrome 8 46 10 60
pseudoexfoliation glaucoma 8 44
pseudoexfoliation syndrome 8 44
exfoliation syndrome, susceptibility to 9


External Ids:

Disease Ontology8 DOID:13641
MeSH34 D017889
SNOMED-CT56 111514006, 44219007
OMIM46 177650
ICD9CM27 365.52

Related Diseases for Exfoliation Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Exfoliation Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1glaucoma31.1LOXL1, TIMP2, NUDT6, GSTP1, ELN
2cataract30.8GSTT1, NUDT6, CAT
3open-angle glaucoma30.5LOXL1, GSTM1, GSTT1, ELN
4hypertension30.4APOE
5primary open angle glaucoma30.3ELN, GSTM1
6senile cataract30.2CAT, GSTM1, GSTT1
7pancreatitis30.2MPO, GSTP1
8hyperhomocysteinemia30.2ELN, APOE
9vascular disease30.0LOX, TIMP2, CAT, APOE, ELN
10abdominal aortic aneurysm29.8APOE
11diabetes mellitus29.8APOE, CAT
12melanoma29.8LOX, TIMP2, CAT, NUDT6, GSTT1
13alzheimer's disease29.8LOX, CAT, APOE, CHRNA4, NUDT6, GSTM1
14retinitis10.3
15ocular hypertension10.2
16retinoschisis10.1
17sensorineural hearing loss10.1
18lattice corneal dystrophy10.0
19bullous keratopathy10.0
20mature cataract10.0
21astigmatism10.0
22corneal dystrophy10.0
23motor neuron disease10.0GSTT1
24ehlers-danlos syndrome10.0ELN
25astrocytoma10.0GSTT1
26psoriasis10.0LOX
27liver cirrhosis10.0LOX
28proliferative diabetic retinopathy10.0TIMP2
29acute pancreatitis10.0MPO
30age related macular degeneration10.0APOE
31cleft palate10.0GSTM1
32inflammatory bowel disease10.0MPO
33esophageal cancer10.0GSTP1
34cleft lip10.0GSTM1
35nephrotic syndrome10.0APOE
36down syndrome10.0APOE
37oral submucous fibrosis10.0LOX
38pituitary tumors10.0NUDT6
39occipital horn syndrome10.0LOX
40graves' disease10.0MPO
41peritonitis10.0MPO
42osteomalacia10.0PHEX
43esophagitis10.0CAT
44galactosemia10.0CAT
45vitiligo10.0CAT
46familial adenomatous polyposis10.0GSTP1
47hepatitis c10.0GSTM1
48amyotrophic lateral sclerosis10.0NUDT6, LOX
49gastritis10.0CAT
50hellp syndrome10.0GSTP1

Graphical network of the top 20 diseases related to Exfoliation Syndrome:



Diseases related to exfoliation syndrome

Clinical Features for Exfoliation Syndrome

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

177650

Clinical synopsis from OMIM:

177650

Drugs & Therapeutics for Exfoliation Syndrome

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Exfoliation Syndrome

Drug clinical trials:

Search ClinicalTrials for Exfoliation Syndrome

Search NIH Clinical Center for Exfoliation Syndrome

Search CenterWatch for Exfoliation Syndrome

Genetic Tests for Exfoliation Syndrome

About this section

Anatomical Context for Exfoliation Syndrome

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Exfoliation Syndrome:

32
Eye, Skin, Retina, Lung, Endothelial

Animal Models for Exfoliation Syndrome or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Exfoliation Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.0ELN, GSTT1, LYST, CHRNA4, PHEX, APOE

Publications for Exfoliation Syndrome

About this section
Sources:
50PubMed
See all sources

Articles related to Exfoliation Syndrome:

(show top 50)    (show all 256)
idTitleAuthorsYear
1
Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population. (23378724)
2013
2
Non-contact in vivo confocal scanning laser microscopy in exfoliation syndrome, exfoliation syndrome suspect and normal eyes. (19860778)
2011
3
An investigation into LOXL1 variants in black South African individuals with exfoliation syndrome. (21320968)
2011
4
Delayed intraocular pressure elevation after pupillary dilation in exfoliation syndrome. (19878115)
2011
5
Exfoliative cytology of the oral mucosa in burning mouth syndrome: a cytomorphological and cytomorphometric analysis. (19702671)
2011
6
Optic nerve head topography in nonglaucomatous, normotensive patients with unilateral exfoliation syndrome. (19242717)
2009
7
Directed therapy for exfoliation syndrome. (19888433)
2009
8
Prooxidant-antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma. (18607617)
2008
9
Noncontact in vivo confocal laser scanning microscopy of exfoliation syndrome. (19277220)
2008
10
Intraocular pressure elevation within the first 24 hours after cataract surgery in patients with glaucoma or exfoliation syndrome. (17561259)
2008
11
The use of microarray technology in deciphering the cause of genetic eye diseases: LOXL1 and exfoliation syndrome. (18282488)
2008
12
Lysyl oxidase-like 1 polymorphisms and exfoliation syndrome in the Japanese population. (18201684)
2008
13
Hemodynamic evaluation of the posterior ciliary circulation in exfoliation syndrome and exfoliation glaucoma. (17111150)
2007
14
Effect of bimatoprost on intraocular pressure after phacoemulsification in eyes with exfoliation syndrome. (17488454)
2007
15
Diurnal variation of intraocular pressure and its correlation with retinal nerve fiber analysis in Turkish patients with exfoliation syndrome. (16075220)
2006
16
Clinical manifestations of staphylococcal scalded-skin syndrome depend on serotypes of exfoliative toxins. (15815014)
2005
17
Effects of apolipoprotein E genotypes on the development of exfoliation syndrome. (15939044)
2005
18
Exfoliation syndrome in Estonian patients scheduled for cataract surgery. (15115445)
2004
19
Why is glaucoma associated with exfoliation syndrome? (12852486)
2003
20
Plasma homocysteine is elevated in patients with exfoliation syndrome. (12834668)
2003
21
Matrix metalloproteinases and their inhibitors in exfoliation syndrome. (12097800)
2002
22
Scanning laser ophthalmoscopy of the optic nerve head in exfoliation glaucoma and ocular hypertension with exfoliation syndrome. (11222334)
2001
23
The exfoliation syndrome in cognitive impairment of cerebrovascular or Alzheimer's type. (11401639)
2001
24
Association of toxic shock syndrome toxin-secreting and exfoliative toxin-secreting Staphylococcus aureus with Kawasaki syndrome complicated by coronary artery disease. (9475299)
1998
25
Other aspects of exfoliation syndrome. (9292658)
1997
26
Isolation and culture of iris pigment epithelium from iridectomy specimens of eyes with and without exfoliation syndrome. (9006431)
1997
27
Possible role of transferrin in exfoliation syndrome. (8739681)
1996
28
Severe congenital generalized exfoliative erythroderma in newborns and infants: a possible sign of Netherton syndrome. (8806118)
1996
29
Exfoliation syndrome and cataract extraction. (8328543)
1993
30
Iris vasculopathy in exfoliation syndrome. An immunocytochemical study. (1750316)
1991
31
Fibrinoid reaction after extracapsular cataract extraction and relationship to exfoliation syndrome. (2810086)
1989
32
Electrophoretic study of proteins associated with pseudo-exfoliation syndrome. (2618644)
1989
33
Exfoliation syndrome. Prevalence in a southeastern United States population. (3345150)
1988
34
Prevalence of exfoliation syndrome in the Japanese. (2853906)
1988
35
Exfoliation syndrome immunological aspects. (2853917)
1988
36
Exfoliation syndrome in the southeastern United States. I. Prevalence in open-angle glaucoma and non-glaucoma populations. (2853929)
1988
37
Unilateral retinitis pigmentosa associated with exfoliation syndrome. (3182175)
1988
38
Argon laser trabeculoplasty in exfoliation syndrome. (4084479)
1985
39
The exfoliation syndrome in the aphakic eye. (7234922)
1981
40
Exfoliation syndrome. (7369310)
1980
41
Pseudo-exfoliation of the lens capsule (exfoliation syndrome) after iridocapsular lensimplantation. (7470710)
1980
42
Onset of the exfoliation syndrome after intracapsular lens extraction. (7369325)
1980
43
The basement membrane exfoliation syndrome. (420639)
1979
44
The exfoliation syndrome. (984637)
1976
45
The pseudo-exfoliation syndrome. A scanning electron microscopic study. II. The posterior chamber region. (1243229)
1975
46
The pseudo-exfoliation syndrome. A scanning electron microscopic study. I. The anterior lens surface. (1243228)
1975
47
The exfoliation syndrome. (4825062)
1974
48
Light and electron microscopy of the anterior iris surface in eyes with and without pseudo-exfoliation syndrome. (4543234)
1973
49
The distribution of the exfoliation material in the iris from eyes with exfoliation syndrome (pseudoexfoliation of the lens capsule). (5316673)
1970
50
Electron microscopy of the wall of iris vessels in eyes with and without exfoliation syndrome (pseudoexfoliation of the lens capsule). (5308349)
1969

Genetic Variations for Exfoliation Syndrome

About this section

Expression for genes affiliated with Exfoliation Syndrome

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Exfoliation Syndrome

Search GEO for disease gene expression data for Exfoliation Syndrome.

Pathways for genes affiliated with Exfoliation Syndrome

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 29KEGG
See all sources

Compounds for genes affiliated with Exfoliation Syndrome

About this section
Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
See all sources

Compounds related to Exfoliation Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7ELN
2bpde4410.5GSTP1
3alpha tocopherol4410.4GSTM1
4methylchloride4410.3GSTT1, GSTM1, GSTP1
5s-phenylmercapturic acid4410.3GSTT1, GSTM1, GSTP1
6cumene hydroperoxide4410.3GSTP1, GSTT1, GSTM1
71,3-butadiene4410.3GSTM1, GSTT1, GSTP1
8bleomycin44 1111.3LOX, APOE, ELN
9indomethacin44 59 28 1113.3ELN, LOX
10styrene4410.2GSTM1, GSTP1, GSTT1
111-hydroxypyrene4410.2GSTM1, GSTT1, GSTP1
12suramin44 28 1112.2NUDT6, APOE
13trichloroethylene4410.2GSTM1, GSTT1, GSTP1
14chi 24410.2GSTM1, GSTT1, TIMP2
15chlorambucil44 1111.2MGST1, GSTP1
16glutathion4410.2CAT, GSTM1, GSTP1
17(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene1110.1GSTP1, GSTM1
18oxaliplatin44 49 1112.0GSTP1, GSTM1, MPO, GSTT1
19d penicillamine4410.0CAT, MPO, LOX, ELN
208-oxo-dg4410.0CAT, GSTT1, GSTM1
21cysteamine44 11 2412.0CAT, APOE, MPO
22isoniazid49 44 1112.0CAT, GSTT1, GSTM1
23quinone44 2411.0GSTT1, CAT, LOX, GSTM1
241-chloro-24-dinitrobenzene4410.0GSTT1, GSTP1, GSTM1, MGST1
25noradrenochrome44 2411.0GSTM1, MGST1, GSTT1, GSTP1
26hydrochloric acid44 2411.0GSTT1, GSTM1, MGST1, GSTP1
27adrenochrome44 2411.0GSTP1, MGST1, GSTM1, GSTT1
28benzene4410.0GSTT1, ELN, GSTM1
29carboplatin44 49 1112.0GSTP1, GSTT1, GSTM1, MPO
30gsts449.9GSTP1, GSTT1, GSTM1, MGST1
31Glutathione11 2410.9GSTM1, MGST1, GSTP1, GSTT1
32manganese superoxide449.9CAT, GSTP1, GSTT1, GSTM1
33epoxide449.9GSTM1, GSTP1, MGST1, GSTT1
34malondialdehyde449.9GSTT1, GSTM1, MPO, CAT
35acetone449.9GSTM1, GSTT1, GSTP1
36betacarotene449.9CAT, ELN, APOE, GSTM1
374-aminobenzoic acid hydrazide449.9CAT, MPO
38dmso449.8CAT, MPO, NUDT6, GSTP1, ELN
39dcnb449.8GSTP1, GSTM1
404-hydroxynonenal44 2410.7GSTP1, GSTM1, MPO, APOE, CAT
41paraffin449.6LOX, TIMP2, APOE, MPO, ELN, GSTP1
42n acetylcysteine449.6ELN, GSTP1, MPO, APOE, CAT, LOX
43h2o2449.5LOX, MPO, CAT, ELN, MGST1, TIMP2
44valine449.5APOE, ELN, MPO, GSTM1, GSTT1, GSTP1
45creatinine449.5APOE, GSTM1, ELN, TIMP2, GSTT1, MPO
46lactate449.3CAT, TIMP2, GSTP1, ELN, GSTM1, MPO
47vegf449.2TIMP2, APOE, MGST1, LOX, NUDT6, GSTP1
48arginine449.1ELN, MGST1, GSTP1, APOE, GSTT1, GSTM1
49ascorbic acid44 2410.0GSTM1, ELN, GSTP1, GSTT1, MPO, APOE
50cysteine448.9ELN, GSTP1, GSTM1, MGST1, APOE, CAT

GO Terms for genes affiliated with Exfoliation Syndrome

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Exfoliation Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particle remodelingGO:03437410.0MPO, APOE
2response to reactive oxygen speciesGO:0003029.9GSTP1, APOE, CAT
3synaptic transmission, cholinergicGO:0072719.8CHRNA4, APOE
4oxidation-reduction processGO:0551149.8MPO, MGST1, LOXL1
5glutathione derivative biosynthetic processGO:19016879.7GSTP1, GSTT1, GSTM1, MGST1
6glutathione metabolic processGO:0067499.7MGST1, GSTM1, GSTT1, GSTP1
7extracellular matrix organizationGO:0301989.7LOXL1, LOX, TIMP2, ELN
8xenobiotic metabolic processGO:0068059.6MGST1, GSTM1, GSTT1, GSTP1
9response to drugGO:0424939.5LOX, TIMP2, MGST1, LYST, GSTT1

Molecular functions related to Exfoliation Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione bindingGO:0432959.6MGST1, GSTM1
2glutathione transferase activityGO:0043649.4GSTP1, GSTT1, GSTM1, MGST1
3enzyme bindingGO:0198999.4GSTM1, AKAP2, CTNNBL1, CAT

Products for genes affiliated with Exfoliation Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Exfoliation Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet