MCID: EXC002
MIFTS: 45

Exocrine Pancreatic Insufficiency malady

Endocrine category

Summaries for Exocrine Pancreatic Insufficiency

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of... more...

MalaCards: Exocrine Pancreatic Insufficiency is related to cystic fibrosis and pancreatitis, chronic. An important gene associated with Exocrine Pancreatic Insufficiency is COX4I2 (cytochrome c oxidase subunit IV isoform 2 (lung)), and among its related pathways are Cobalamin (Cbl, vitamin B12) transport and metabolism and Digestion of dietary lipid. The compounds epft and l-bpa have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and bone marrow, and related mouse phenotypes are digestive/alimentary and growth/size.

Aliases & Classifications for Exocrine Pancreatic Insufficiency

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

exocrine pancreatic insufficiency 8 10 45 61


External Ids:

Disease Ontology8 DOID:13316
MeSH35 D010188
SNOMED-CT57 47367009
NCIt40 C84316

Related Diseases for Exocrine Pancreatic Insufficiency

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Exocrine Pancreatic Insufficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1cystic fibrosis31.3CFTR, PNLIP, CELA3B, CELA1, ELANE, SCT
2pancreatitis, chronic31.0CEL, CCK, ELANE, PRSS3, CFTR, PNLIP
3pancreatic steatorrhea30.7CELA3B, PNLIP, CELA1
4steatorrhea30.7CELA1, CELA3B, PNLIP, ELANE, CFTR, CLPS
5irritable bowel syndrome30.3CCK
6alcoholic pancreatitis30.3CCK, ELANE, CFTR, SCT
7n syndrome10.5
8shwachman-diamond syndrome10.5
9exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.5
10neurofibromatosis10.4
11somatostatinoma10.4
12pancreatic somatostatinoma10.4
13celiac disease10.4
14duodenal somatostatinoma10.4
15dwarfism10.4
16atrophic gastritis10.2
17autoimmune thyroiditis10.2
18cutis laxa10.2
19hepatitis e10.2
20tropical sprue10.2
21autoimmune hepatitis10.2
22hepatitis d10.2
23anorexia nervosa10.2
24hepatitis a10.2
25adenocarcinoma10.2
26thyroiditis10.2
27type 2 diabetes mellitus10.2
28micro syndrome10.2
29autoimmune atrophic gastritis10.2
30calvarial hyperostosis10.2
31diabetes, type 210.2
32nutrition disease10.2
33protein-energy malnutrition10.0CCK
34intestinal obstruction10.0CFTR
35cholesterol ester storage disease10.0PNLIP
36cholangitis10.0CFTR
37duodenogastric reflux10.0CCK
38recurrent acute pancreatitis10.0SCT, CFTR
39pustulosis palmaris et plantaris10.0ELANE
40hypoglycemia10.0SCT, PPY
41vipoma10.0SCT
42peptic ulcer10.0SCT, CCK
43gallbladder disease10.0CFTR, CCK
44bronchitis10.0CD79A
45duodenal ulcer10.0PPY, CCK, SCT
46galactosemia10.0CD79A
47hereditary pancreatitis10.0PRSS3, CFTR
48pancreatic cancer10.0CCK, SCT, CEL
49respiratory failure10.0CCK, CFTR
50obesity10.0PNLIP, CLPS, CCK

Graphical network of the top 20 diseases related to Exocrine Pancreatic Insufficiency:



Diseases related to exocrine pancreatic insufficiency

Clinical Features for Exocrine Pancreatic Insufficiency

Drugs & Therapeutics for Exocrine Pancreatic Insufficiency

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Exocrine Pancreatic Insufficiency

Drug clinical trials:

Search ClinicalTrials for Exocrine Pancreatic Insufficiency

Search NIH Clinical Center for Exocrine Pancreatic Insufficiency

Search CenterWatch for Exocrine Pancreatic Insufficiency

Genetic Tests for Exocrine Pancreatic Insufficiency

Anatomical Context for Exocrine Pancreatic Insufficiency

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Exocrine Pancreatic Insufficiency:

33
Skin, Liver, Bone marrow, Small intestine, Colon, Pancreas, Thyroid, Salivary gland, B cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Exocrine Pancreatic Insufficiency:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic AciniAcinar Cells Potential therapeutic candidate, affected by disease

Animal Models for Exocrine Pancreatic Insufficiency or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Exocrine Pancreatic Insufficiency:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5UBR1, CLPS, SBDS, CFTR, PNLIP, CEL
2MP:00053787.9UBR1, PPY, MEP1B, CLPS, SBDS, CFTR
3MP:00053767.3ELANE, COX4I2, CCK, UBR1, SCT, MEP1B

Publications for Exocrine Pancreatic Insufficiency

Sources:
51PubMed
See all sources

Articles related to Exocrine Pancreatic Insufficiency:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
GATA6 mutations cause a broad phenotypic spectrum of diabetes from pancreatic agenesis to adult-onset diabetes without exocrine insufficiency. (23223019)
2013
2
Low prevalence of exocrine pancreatic insufficiency in patients with diabetes mellitus. (23890131)
2013
3
Biallelic PDX1 (insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency. (23320570)
2013
4
Recovery from exocrine pancreatic insufficiency in a patient with fulminant type 1 diabetes. (23448767)
2013
5
Early spontaneous recovery of exocrine pancreatic insufficiency in a 3-year-old child with Shwachman-Diamond syndrome. (24052373)
2013
6
The growing pancreatic duct ligated pig as a model for exocrine pancreatic insufficiency in children: investigations to achieve sufficient vitamin A and vitamin E supply. (23365367)
2012
7
Hyperammonaemia due to cobalamin malabsorption in a cat with exocrine pancreatic insufficiency. (22907395)
2012
8
Introduction: exocrine pancreatic insufficiency and pancreatitis. (23148847)
2012
9
Exocrine pancreatic insufficiency in the dog: breed associations, nutritional considerations, and long-term outcome. (23148849)
2012
10
Protein-losing enteropathy in a dog with lymphangiectasia, lymphoplasmacytic enteritis and pancreatic exocrine insufficiency. (23106499)
2012
11
A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery. (21418260)
2011
12
Efficacy and safety of PANCREAZEAr for treatment of exocrine pancreatic insufficiency due to cystic fibrosis. (21632288)
2011
13
Severe impaired deambulation in a patient with vitamin D and mineral deficiency due to exocrine pancreatic insufficiency. (21904076)
2011
14
Increased postprandial response of glucagon-like peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency. (20460948)
2010
15
Suppressed glucose metabolism in acinar cells might contribute to the development of exocrine pancreatic insufficiency in streptozotocin-induced diabetic mice. (20051281)
2010
16
Efficacy and tolerability of a new formulation of pancrelipase delayed-release capsules in children aged 7 to 11 years with exocrine pancreatic insufficiency and cystic fibrosis: a multicenter, randomized, double-blind, placebo-controlled, two-period crossover, superiority study. (20171415)
2010
17
Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis. (19815466)
2009
18
Pancreatic enzyme replacement therapy: exocrine pancreatic insufficiency after gastrointestinal surgery. (20495625)
2009
19
Comment on "Lw fecal elastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1 diabetes mellitus (pancreas. 2008;36:274-278)". (19390407)
2009
20
Exocrine pancreatic insufficiency treatment study. (19596684)
2009
21
Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression. (18806227)
2008
22
Is exocrine pancreatic insufficiency in adult coeliac disease a cause of persisting symptoms? (17269988)
2007
23
Exocrine pancreatic insufficiency and its consequences on physical development and metabolism in children and adolescents with type 1 diabetes mellitus. (15300430)
2004
24
Mechanism of exocrine pancreatic insufficiency in streptozotocin-induced diabetes mellitus in rat: effect of cholecystokinin-octapeptide. (15362489)
2004
25
Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dogs. (12866928)
2003
26
Transient exocrine pancreatic insufficiency as a possible complication of an enterovirus infection. (14513373)
2003
27
Stimulation of immunoglobulin E formation in chronic pancreatitis by alcohol drinking and exocrine pancreatic insufficiency]. (11367975)
2001
28
Diagnostic value of amino acid consumption test on exocrine pancreatic insufficiency. (11819580)
2000
29
Comparison of two tubeless function tests in the assessment of mild-to-moderate exocrine pancreatic insufficiency. (11192324)
2000
30
Exocrine pancreatic insufficiency in a cat. (9578779)
1998
31
Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea? (9178698)
1997
32
Comparative evaluation of a high lipase pancreatic enzyme preparation and a standard pancreatic supplement for treating exocrine pancreatic insufficiency in chronic pancreatitis. (8853261)
1996
33
Gene therapy for exocrine pancreatic insufficiency. (8194722)
1994
34
Origin and development of exocrine pancreatic insufficiency in experimental renal failure. (7512063)
1994
35
Complex carbohydrate malabsorption in exocrine pancreatic insufficiency. (8344588)
1993
36
Changed integrated gastrointestinal response to a mixed meal in exocrine pancreatic insufficiency. (1553369)
1992
37
Testing for exocrine pancreatic insufficiency in cats. (2254135)
1990
38
Radioimmunoassay for assessing exocrine pancreatic insufficiency, based on the differential enzymatic degradation of cobalamin-binding proteins. (3512129)
1986
39
Evaluation of serum pancreatic polypeptide estimations following hormonal stimulation for the diagnosis of exocrine pancreatic insufficiency. (6510573)
1984
40
Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease. (6206989)
1984
41
Diagnosis of exocrine pancreatic insufficiency from stool fat and weight. (6843046)
1983
42
Effect of diet on exocrine pancreatic insufficiency in dogs. (6921199)
1982
43
Specificity of the BT-PABA test for the diagnosis of exocrine pancreatic insufficiency in the dog. (6972120)
1981
44
Influence of exocrine pancreatic insufficiency on the intraluminal pH of the proximal small intestine. (37059)
1979
45
Biochemical changes in the jejunal mucosa of dogs with naturally occurring exocrine pancreatic insufficiency. (488765)
1979
46
Exocrine pancreatic insufficiency syndrome in CBA/J mice. III. Pathological and genetic analysis. (873127)
1977
47
Exocrine pancreatic insufficiency syndrome in CBA/J mice. II. Biochemical studies. (64119)
1977
48
Exocrine pancreatic insufficiency with congenital anomalies. (978327)
1976
49
The syndrome of exocrine pancreatic insufficiency, neutropenia, metaphyseal dysostosis and dwarfism. (5370796)
1969
50
Pancreatic exocrine insufficiency and proteolytic enzymes in stool. A critical evaluation of a new diagnostic test in various forms of steatorrhea. (5972656)
1966

Genetic Variations for Exocrine Pancreatic Insufficiency

Expression for genes affiliated with Exocrine Pancreatic Insufficiency

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Exocrine Pancreatic Insufficiency

Search GEO for disease gene expression data for Exocrine Pancreatic Insufficiency.

Pathways for genes affiliated with Exocrine Pancreatic Insufficiency

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7GIF, PRSS3
29.6CEL, PNLIP, CLPS
3
Hide members
9.6CEL, PNLIP, CLPS
49.6CEL, PNLIP, CLPS
59.3CELA3B, PRSS3, MEP1B
69.3PNLIP, ABHD6
78.8CEL, CELA3B, PNLIP, CFTR, PRSS3

Compounds for genes affiliated with Exocrine Pancreatic Insufficiency

Sources:
45Novoseek, 2BitterDB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 50PharmGKB
See all sources

Compounds related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1epft4510.5CCK, SCT
2l-bpa4510.5SCT, CCK
3h2dids4510.5CFTR, SCT
4caerulein4510.5CCK, SCT
5pancreozymin4510.4CCK, SCT
6saccharin45 211.4CCK, ELANE
7Mdl 101,1461110.4CELA1, ELANE
8loxiglumide4510.4CCK, SCT
9ethylenediamine4510.4CEL, ELANE
10ONO-68181110.4CELA1, ELANE
11pepsinogen4510.3CCK, SCT
12cerulein4510.3ELANE, SCT, CCK
13olestra4510.3PNLIP, CCK
14METHOXYUNDECYLPHOSPHINIC ACID1110.3CLPS, PNLIP
15taurodeoxycholate4510.3CCK, SCT, CLPS
16p-nitrophenyl acetate4510.3PNLIP, CEL
17(Hydroxyethyloxy)Tri(Ethyloxy)Octane1110.2PNLIP, CLPS
18pristimerin6010.2PNLIP, CEL
19gsk 264220a6010.2PNLIP, CEL
20jzl 1846010.2PNLIP, CEL
21lactulose4510.2CD79A, CCK
22enterostatin4510.2CCK, CLPS
23nppb45 60 2912.1CFTR, SCT
24cholic acid45 29 11 2413.1COX4I1, PNLIP, CEL
25vancomycin45 1111.1CD79A, ELANE
26carbachol45 29 1111.9CCK, SCT, CD79A, CFTR
27octreotide45 60 29 1112.9CCK, SCT, PNLIP, ELANE
28oleic acid45 29 11 2412.9SCT, PNLIP, CEL
29chloroquine45 2 50 29 1113.9CEL, CFTR, CD79A
30norepinephrine45 11 2411.9CCK, CFTR, PNLIP, ELANE
31triacylglycerol459.9CEL, PNLIP, CLPS
32orlistat45 60 1111.9CEL, PNLIP, CLPS, CCK
33aspirin45 50 29 2412.9ELANE, CFTR, CD79A, CCK
34azithromycin45 1110.8CFTR, CD79A
35epinephrine45 11 2411.8SCT, CD79A, CFTR, ELANE
36acetylcholine45 50 29 11 2413.7CCK, SCT, CD79A, CFTR, ELANE
37taurocholate459.7CCK, SCT, CFTR, PNLIP, CEL
38bicarbonate459.7CCK, SCT, CFTR, PNLIP, CEL
39adenylate459.7CCK, SCT, CFTR, CEL, ELANE
40cyclosporin a45 29 6011.7CCK, SCT, CD79A, CFTR, ELANE
41pge2459.7ELANE, CFTR, CD79A, SCT, CCK
42phosphatidylcholine459.7CD79A, CLPS, PNLIP, CEL
43phospholipid459.6COX4I1, SCT, CLPS, PNLIP, CEL
44thyroxine45 2410.6SCT, PRSS3, CD79A, ELANE
45glycerol45 11 2411.6CCK, CD79A, CFTR, PNLIP, CEL
46polysaccharide459.6CEL, CD79A, MEP1B, CCK
47biotin45 11 2411.4CFTR, CD79A, SCT
48testosterone45 60 11 2412.3CCK, SCT, CD79A, CFTR, ELANE
49glutamate459.3CCK, SCT, CD79A, CFTR, PNLIP, ELANE
50trypsinogen459.2ELANE, PNLIP, CFTR, PRSS3, SCT, CCK

GO Terms for genes affiliated with Exocrine Pancreatic Insufficiency

Sources:
16Gene Ontology
See all sources

Cellular components related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.1ELANE, SCT, PPY, PRSS3, GIF, CLPS

Biological processes related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pancreatic juice secretionGO:03015710.2CEL, SCT
2intestinal cholesterol absorptionGO:0302999.8CEL, PNLIP
3lipid digestionGO:0442419.8CEL, PNLIP, CLPS
4cobalamin metabolic processGO:0092359.7GIF, PRSS3
5digestionGO:0075869.4PPY, MEP1B, PRSS3
6proteolysisGO:0065088.8MEP1B, PRSS3, CELA3B, CELA1, ELANE
7small molecule metabolic processGO:0442817.7COX4I1, PRSS3, GIF, EPT1, CLPS, PNLIP

Molecular functions related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride lipase activityGO:0048069.9CEL, PNLIP
2acylglycerol lipase activityGO:0473729.4ABHD6, CEL
3hormone activityGO:0051799.3PPY, SCT, CCK
4serine-type endopeptidase activityGO:0042529.1ELANE, CELA1, CELA3B, PRSS3

Products for genes affiliated with Exocrine Pancreatic Insufficiency

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Exocrine Pancreatic Insufficiency

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet