MCID: EXC002
MIFTS: 41

Exocrine Pancreatic Insufficiency malady

Endocrine diseases category

Summaries for Exocrine Pancreatic Insufficiency

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Wikipedia:63 Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of... more...

MalaCards based summary: Exocrine Pancreatic Insufficiency is related to pancreatitis and cystic fibrosis. An important gene associated with Exocrine Pancreatic Insufficiency is COX4I2 (cytochrome c oxidase subunit IV isoform 2 (lung)), and among its related pathways are AMPK Enzyme Complex Pathway and Pancreatic secretion. The compounds epft and taurodeoxycholate have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and small intestine, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Exocrine Pancreatic Insufficiency

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Exocrine Pancreatic Insufficiency, Aliases & Descriptions:

Name: Exocrine Pancreatic Insufficiency 30 9 11 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:13316
NCIt38 C84316
SNOMED-CT55 47367009
MeSH33 D010188

Related Diseases for Exocrine Pancreatic Insufficiency

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Diseases related to Exocrine Pancreatic Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.4PNLIP, PPY, CFTR, SCT, ELANE, CELA3B
2cystic fibrosis31.2PNLIP, CFTR, SCT, ELANE, CELA3B, CELA1
3gastritis30.6SCT, CCK, CD79A
4steatorrhea30.5PNLIP, CCK, CELA1, CELA3B, ELANE, SCT
5pancreatitis, hereditary30.3PNLIP, CFTR, SCT, ELANE, CEL, CCK
6adenocarcinoma30.2PNLIP, SCT, CEL, CCK, PDX1
7exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.6
8shwachman-bodian-diamond syndrome10.6
9duodenitis10.5
10duodenogastric reflux10.5CCK
11johanson-blizzard syndrome10.5
12blindness10.5
13keratoconjunctivitis sicca10.5CFTR
14renal cysts and diabetes syndrome10.4
15celiac disease10.4
16neutropenia10.4
17somatostatinoma10.4
18neurofibromatosis10.4
19dysostosis10.4
20metaphyseal dysplasia10.4
21dwarfism10.4
22recurrent acute pancreatitis10.4CFTR, SCT
23pustulosis palmaris et plantaris10.4ELANE
24giardiasis10.3CD79A
25gallbladder disease10.3CCK, CFTR
26conjunctivitis10.3CD79A
27prostatitis10.3CD79A
28cystic kidney10.3SCT, CFTR
29aspergillosis10.3ELANE, CD79A
30nutritional deficiency disease10.3SCT, CEL, CCK
31duodenal ulcer10.3CCK, SCT, PPY
32alcohol dependence10.2CFTR, SCT, CCK
33pancreatic cancer10.2CCK, CEL, SCT
34beckwith-wiedemann syndrome10.2
35pancreatic agenesis 110.2
36cystinosis, nephropathic10.2
37fabry disease10.2
38obesity10.2
39anorexia nervosa10.2
40alagille syndrome10.2
41wolcott-rallison syndrome10.2
42multiple endocrine neoplasia 110.2
43autoimmune hepatitis10.2
44diabetic neuropathy10.2
45hepatitis10.2
46liver disease10.2
47pearson syndrome10.2
48atrophic gastritis10.2
49tropical sprue10.2
50irritable bowel syndrome10.2

Graphical network of the top 20 diseases related to Exocrine Pancreatic Insufficiency:



Diseases related to exocrine pancreatic insufficiency

Symptoms for Exocrine Pancreatic Insufficiency

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Drugs & Therapeutics for Exocrine Pancreatic Insufficiency

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Drug clinical trials:

Search ClinicalTrials for Exocrine Pancreatic Insufficiency

Search NIH Clinical Center for Exocrine Pancreatic Insufficiency

Genetic Tests for Exocrine Pancreatic Insufficiency

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Anatomical Context for Exocrine Pancreatic Insufficiency

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MalaCards organs/tissues related to Exocrine Pancreatic Insufficiency:

31
Pancreas, Testes, Small intestine, Liver, Neutrophil, Bone marrow, Bone, Colon, Thyroid, Salivary gland, Skin

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Exocrine Pancreatic Insufficiency:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic AciniAcinar Cells Potential therapeutic candidate, affected by disease

Animal Models for Exocrine Pancreatic Insufficiency or affiliated genes

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MGI Mouse Phenotypes related to Exocrine Pancreatic Insufficiency:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6PDX1, SBDS, CEL, CFTR, PNLIP
2MP:00053818.1PNLIP, CFTR, CEL, SBDS, PDX1, UBR1
3MP:00053766.9CD79A, PNLIP, CFTR, SCT, ELANE, CEL
4MP:00053786.9PPY, PNLIP, CFTR, CEL, SBDS, COX4I2

Publications for Exocrine Pancreatic Insufficiency

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Articles related to Exocrine Pancreatic Insufficiency:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
Case report of exocrine pancreatic insufficiency in two palliative care patients. (24699789)
2014
2
Safety and efficacy of CreonAr Micro in children with exocrine pancreatic insufficiency due to cystic fibrosis. (25066363)
2014
3
Johanson-Blizzard syndrome: expanding the phenotype of exocrine pancreatic insufficiency. (25076350)
2014
4
CTLA-4 +49 and TNF-alpha-308 gene polymorphisms in celiac patients with exocrine pancreatic insufficiency. (24611333)
2013
5
Low prevalence of exocrine pancreatic insufficiency in patients with diabetes mellitus. (23890131)
2013
6
Biallelic PDX1 (insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency. (23320570)
2013
7
The growing pancreatic duct ligated pig as a model for exocrine pancreatic insufficiency in children: investigations to achieve sufficient vitamin A and vitamin E supply. (23365367)
2012
8
Hyperammonaemia due to cobalamin malabsorption in a cat with exocrine pancreatic insufficiency. (22907395)
2012
9
Prevalence of exocrine pancreatic insufficiency in women with obesity syndrome: assessment by pancreatic fecal elastase 1. (22111014)
2011
10
A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery. (21418260)
2011
11
Evaluation of stool collections to measure efficacy of PERT in subjects with exocrine pancreatic insufficiency. (21681115)
2011
12
Heritability of exocrine pancreatic insufficiency in German Shepherd dogs. (20102502)
2010
13
IBS: Do we need to exclude exocrine pancreatic insufficiency in IBS? (20811362)
2010
14
An online resource for canine exocrine pancreatic insufficiency. (21137601)
2010
15
Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis. (19815466)
2009
16
Pancreatic enzyme replacement therapy: exocrine pancreatic insufficiency after gastrointestinal surgery. (20495625)
2009
17
An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency. (19297056)
2009
18
Predictive factors for exocrine pancreatic insufficiency after pancreatoduodenectomy with pancreaticogastrostomy. (19415402)
2009
19
A case of fulminant type 1 diabetes mellitus with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion. (18789550)
2008
20
Juvenile diabetes mellitus accompanied by exocrine pancreatic insufficiency in a dog. (19122401)
2008
21
Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial. (17103488)
2007
22
Exocrine pancreatic insufficiency in pigeons. (16448944)
2006
23
Effects of diet on clinical signs of exocrine pancreatic insufficiency in dogs. (16426193)
2006
24
Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study. (16036530)
2005
25
Exocrine pancreatic insufficiency and adverse reaction to food in dogs: a positive response to a high-fat, soy isolate hydrolysate-based diet. (15284428)
2004
26
Exocrine pancreatic insufficiency in dogs. (14552166)
2003
27
Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dogs. (12866928)
2003
28
Oral bleeding associated with pancreatic enzyme supplementation in three dogs with exocrine pancreatic insufficiency. (12494968)
2002
29
An immunoassay for canine pancreatic elastase 1 as an indicator for exocrine pancreatic insufficiency in dogs. (11724136)
2001
30
Iron, zinc, and copper concentration in serum, various organs, and hair of dogs with experimentally induced exocrine pancreatic insufficiency. (11478496)
2001
31
Stimulation of immunoglobulin E formation in chronic pancreatitis by alcohol drinking and exocrine pancreatic insufficiency]. (11367975)
2001
32
Serum feline trypsin-like immunoreactivity in cats with exocrine pancreatic insufficiency. (11110385)
2000
33
Detection and follow up of exocrine pancreatic insufficiency in cystic fibrosis: a review. (10968231)
2000
34
Response to long-term enzyme replacement treatment in dogs with exocrine pancreatic insufficiency. (9656030)
1998
35
Exocrine pancreatic insufficiency in celiac disease. (9496962)
1998
36
Intestinal permeability in exocrine pancreatic insufficiency due to cystic fibrosis or chronic pancreatitis. (8725259)
1996
37
Effect of treatment on the jejunal and colonic bacterial flora of dogs with exocrine pancreatic insufficiency. (8302792)
1993
38
Adequate enzymatic substitution in treating exocrine pancreatic insufficiency. (7526630)
1993
39
Diabetes mellitus and exocrine pancreatic insufficiency in a girl with auto-immune haemolysis. (1628669)
1992
40
Ichthyosis, exocrine pancreatic insufficiency, impaired neutrophil chemotaxis, growth retardation, and metaphyseal dysplasia. (1892416)
1991
41
High serum trypsin-like immunoreactivity secondary to pancreatitis in a dog with exocrine pancreatic insufficiency. (2105925)
1990
42
Evaluation of faecal analysis as an aid to the detection of exocrine pancreatic insufficiency. (3382906)
1988
43
Enteropeptidase (EC 3.4.21.9) in coeliac disease and exocrine pancreatic insufficiency. (2962436)
1987
44
Exocrine pancreatic insufficiency and idiopathic haemochromatosis. (6494088)
1984
45
Evaluation of serum pancreatic polypeptide estimations following hormonal stimulation for the diagnosis of exocrine pancreatic insufficiency. (6510573)
1984
46
Quantitative assessment of fat absorption and its diagnostic value in exocrine pancreatic insufficiency. (6635347)
1983
47
Comparative evaluation of the therapeutic efficacy of a pH-sensitive enteric coated pancreatic enzyme preparation with conventional pancreatic enzyme therapy in the treatment of exocrine pancreatic insufficiency. (6549746)
1983
48
The intraluminal transport of vitamin B12 and the exocrine pancreatic insufficiency. (450901)
1979
49
Exocrine pancreatic insufficiency syndrome in CBA/J mice. III. Pathological and genetic analysis. (873127)
1977
50
Electron microscopic examination of cartilage in the syndrome of exocrine pancreatic insufficiency, neutropenia, metaphyseal dysostosis and dwarfism. (4141701)
1974

Variations for Exocrine Pancreatic Insufficiency

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Expression for genes affiliated with Exocrine Pancreatic Insufficiency

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Search GEO for disease gene expression data for Exocrine Pancreatic Insufficiency.

Pathways for genes affiliated with Exocrine Pancreatic Insufficiency

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Pathways related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7COX4I1, COX4I2, CFTR
28.8CEL, CELA3B, CFTR, PNLIP

Compounds for genes affiliated with Exocrine Pancreatic Insufficiency

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Compounds related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1epft4310.4CCK, SCT
2taurodeoxycholate4310.4SCT, CCK
3l-bpa4310.4SCT, CCK
4caerulein4310.4CCK, SCT
5h2dids4310.4SCT, CFTR
6saccharin43 211.3CCK, ELANE
7pancreozymin4310.3SCT, CCK
8loxiglumide4310.3SCT, CCK
9ethylenediamine4310.3ELANE, CEL
10pepsinogen4310.3SCT, CCK
11cerulein4310.2SCT, ELANE, CCK
12olestra4310.1CCK, PNLIP
13lactulose4310.1CD79A, CCK
14vancomycin43 1211.1CD79A, ELANE
15p-nitrophenyl acetate4310.0PNLIP, CEL
16pristimerin5910.0PNLIP, CEL
17gsk 264220a5910.0PNLIP, CEL
18jzl 1845910.0PNLIP, CEL
19c-peptide439.9PDX1, CCK, SCT
20orlistat43 59 1211.9CCK, CEL, PNLIP
21incretin439.8PDX1, CCK
22chloroquine43 2 49 28 1213.8CD79A, CEL, CFTR
23biotin43 24 1211.8CFTR, SCT, CD79A
24caffeine43 28 2 49 24 1214.8CFTR, ELANE, CCK
25carbachol43 28 1211.8CFTR, SCT, CCK, CD79A
26cholic acid43 28 24 1212.8PNLIP, CEL, COX4I1
27oleic acid43 28 24 1212.7CEL, SCT, PNLIP
28chlorine43 2410.7CD79A, ELANE, CFTR
29aspirin43 49 28 2412.7CD79A, CCK, ELANE, CFTR
30azithromycin43 1210.7CFTR, CD79A
31epinephrine43 24 1211.7CFTR, SCT, ELANE, CD79A
32octreotide43 59 28 1212.7PNLIP, SCT, ELANE, CCK
33glutamine439.6CFTR, SCT, ELANE, CCK
34adenylate439.6CFTR, SCT, ELANE, CEL, CCK
35acetylcholine43 49 28 24 1213.5CFTR, SCT, ELANE, CCK, CD79A
36cyclosporin a43 28 5911.5CFTR, SCT, ELANE, CCK, CD79A
37pge2439.5CFTR, SCT, ELANE, CCK, CD79A
38forskolin43 49 1211.5CFTR, SCT, CCK, PDX1
39testosterone43 59 24 1212.5CFTR, SCT, ELANE, CCK, CD79A
40phospholipid439.4PNLIP, SCT, CEL, COX4I1
41trypsinogen439.4CCK, ELANE, SCT, CFTR, PNLIP
42taurocholate439.4PNLIP, CFTR, SCT, CEL, CCK
43bicarbonate439.4PNLIP, CFTR, SCT, CEL, CCK
44glycerol43 24 1211.2CD79A, CCK, CEL, CFTR, PNLIP
45dopamine43 28 24 1212.0CFTR, SCT, CCK, CD79A
46retinoic acid43 2410.0CFTR, SCT, ELANE, CCK, PDX1, CD79A
47norepinephrine43 24 1211.0CD79A, CCK, ELANE, SCT, CFTR, PNLIP
48glutamate439.0PNLIP, CFTR, SCT, ELANE, CCK, CD79A
49oxygen43 249.9COX4I1, COX4I2, CEL, ELANE, PNLIP
50serine438.5PNLIP, CFTR, SCT, ELANE, CEL, PDX1

GO Terms for genes affiliated with Exocrine Pancreatic Insufficiency

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Cellular components related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.8CCK, CEL, CELA1, ELANE, SCT, PNLIP

Biological processes related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1pancreatic juice secretionGO:003015710.0SCT, CEL
2hydrogen ion transmembrane transportGO:019026009.9COX4I1, COX4I2
3lipid digestionGO:00442419.8CEL, PNLIP
4generation of precursor metabolites and energyGO:00060919.6PDX1, COX4I1, COX4I2
5intestinal cholesterol absorptionGO:00302999.6CEL, PNLIP
6exocrine pancreas developmentGO:00310179.4PDX1, CELA1

Molecular functions related to Exocrine Pancreatic Insufficiency according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1triglyceride lipase activityGO:00048069.4CEL, PNLIP
2serine-type endopeptidase activityGO:00042529.3CELA1, CELA3B, ELANE
3hormone activityGO:00051799.1CCK, SCT, PPY

Products for genes affiliated with Exocrine Pancreatic Insufficiency

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Sources for Exocrine Pancreatic Insufficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet