MCID: EXC002
MIFTS: 47

Exocrine Pancreatic Insufficiency malady

Endocrine diseases category

Summaries for Exocrine Pancreatic Insufficiency

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63Wikipedia, 32MalaCards
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Wikipedia:63 Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of... more...

MalaCards: Exocrine Pancreatic Insufficiency is related to pancreatitis and cystic fibrosis. An important gene associated with Exocrine Pancreatic Insufficiency is COX4I2 (cytochrome c oxidase subunit IV isoform 2 (lung)), and among its related pathways are Cobalamin (Cbl, vitamin B12) transport and metabolism and Digestion of dietary lipid. The compounds epft and l-bpa have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreas and small intestine, and related mouse phenotypes are digestive/alimentary and growth/size.

Aliases & Classifications for Exocrine Pancreatic Insufficiency

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

exocrine pancreatic insufficiency 8 10 44 60


External Ids:

Disease Ontology8 DOID:13316
MeSH34 D010188
SNOMED-CT56 47367009
NCIt39 C84316

Related Diseases for Exocrine Pancreatic Insufficiency

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17GeneCards, 18GeneDecks
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Diseases related to Exocrine Pancreatic Insufficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis32.0PPY, PRSS3, CLPS, CFTR, PNLIP, CELA3B
2cystic fibrosis31.2SCT, CFTR, PNLIP, CELA3B, CELA1, ELANE
3diabetes mellitus31.1CD79A, PPY, SCT, CCK
4pancreatic steatorrhea30.7CELA1, CELA3B, PNLIP
5steatorrhea30.7CCK, SCT, CLPS, CFTR, PNLIP, CELA3B
6alcoholic pancreatitis30.5CCK, SCT, CFTR, ELANE
7irritable bowel syndrome30.3CCK
8respiratory failure30.2CFTR, CCK
9obesity30.2CCK, CLPS, PNLIP
10gastritis30.2CCK, SCT, GIF, CD79A
11duodenitis10.5
12shwachman-diamond syndrome10.5
13exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.5
14type 1 diabetes mellitus10.4
15neurofibromatosis10.3
16somatostatinoma10.3
17pancreatic somatostatinoma10.3
18celiac disease10.3
19duodenal somatostatinoma10.3
20dysostosis10.3
21metaphyseal dysplasia10.3
22neutropenia10.3
23dwarfism10.3
24crohn's disease10.2
25atrophic gastritis10.2
26autoimmune thyroiditis10.2
27cutis laxa10.2
28tropical sprue10.2
29autoimmune hepatitis10.2
30anorexia nervosa10.2
31addison's disease10.2
32hepatitis a10.2
33adenocarcinoma10.2
34diabetic neuropathy10.2
35duodenal disease10.2
36hepatitis10.2
37hyperostosis10.2
38lactic acidosis10.2
39neuropathy10.2
40thyroiditis10.2
41protein-energy malnutrition10.0CCK
42intestinal obstruction10.0CFTR
43cholesterol ester storage disease10.0PNLIP
44cholangitis10.0CFTR
45pustulosis palmaris et plantaris10.0ELANE
46recurrent acute pancreatitis10.0CFTR, SCT
47duodenogastric reflux10.0CCK
48hypoglycemia10.0PPY, SCT
49vipoma10.0SCT
50peptic ulcer10.0SCT, CCK

Graphical network of the top 20 diseases related to Exocrine Pancreatic Insufficiency:



Diseases related to exocrine pancreatic insufficiency

Clinical Features for Exocrine Pancreatic Insufficiency

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Drugs & Therapeutics for Exocrine Pancreatic Insufficiency

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Exocrine Pancreatic Insufficiency

Search NIH Clinical Center for Exocrine Pancreatic Insufficiency

Search CenterWatch for Exocrine Pancreatic Insufficiency

Genetic Tests for Exocrine Pancreatic Insufficiency

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Anatomical Context for Exocrine Pancreatic Insufficiency

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Exocrine Pancreatic Insufficiency:

32
Testes, Pancreas, Small intestine, Colon, Thyroid, Bone marrow, Liver, Bone, Skin, Salivary gland

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Exocrine Pancreatic Insufficiency:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic AciniAcinar Cells Potential therapeutic candidate, affected by disease

Animal Models for Exocrine Pancreatic Insufficiency or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Exocrine Pancreatic Insufficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5UBR1, CLPS, SBDS, CFTR, PNLIP, CEL
2MP:00053787.9PNLIP, CFTR, SBDS, CLPS, MEP1B, PPY
3MP:00053767.3COX4I2, ELANE, CEL, PNLIP, CFTR, SBDS

Publications for Exocrine Pancreatic Insufficiency

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50PubMed
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Articles related to Exocrine Pancreatic Insufficiency:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
GATA6 mutations cause a broad phenotypic spectrum of diabetes from pancreatic agenesis to adult-onset diabetes without exocrine insufficiency. (23223019)
2013
2
Recovery from exocrine pancreatic insufficiency in a patient with fulminant type 1 diabetes. (23448767)
2013
3
Exocrine pancreatic insufficiency in the cat. (23148851)
2012
4
Efficacy of a novel pancreatic enzyme product, EUR-1008 (Zenpep), in patients with exocrine pancreatic insufficiency due to chronic pancreatitis. (21343835)
2011
5
Irreversible exocrine pancreatic insufficiency in alcoholic rats without chronic pancreatitis after alcohol withdrawal. (20662806)
2010
6
Pancreatic enzyme replacement therapy: exocrine pancreatic insufficiency after gastrointestinal surgery. (20495625)
2009
7
Predictive factors for exocrine pancreatic insufficiency after pancreatoduodenectomy with pancreaticogastrostomy. (19415402)
2009
8
Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene. (19268275)
2009
9
A case of fulminant type 1 diabetes mellitus with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion. (18789550)
2008
10
Mechanism of exocrine pancreatic insufficiency in streptozotocin-induced type 1 diabetes mellitus. (17151294)
2006
11
Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study. (16036530)
2005
12
Liver biochemical and histopathological findings in dogs with experimentally induced exocrine pancreatic insufficiency. (14979436)
2004
13
Effects of exchange of dietary medium chain triglycerides for long-chain triglycerides on serum biochemical variables and subjectively assessed well-being of dogs with exocrine pancreatic insufficiency. (15478780)
2004
14
Hydrogen breath test with low-dose rice flour for assessment of exocrine pancreatic insufficiency. (15502647)
2004
15
High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients. (14526149)
2003
16
High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: a prospective multicenter study. (14560984)
2003
17
Subclinical exocrine pancreatic insufficiency in dogs. (11990965)
2002
18
A patient with autoimmune hepatitis type I, Addison's disease, atrophic thyroiditis, atrophic gastritis, exocrine pancreatic insufficiency, and heterozygous alpha1-antitrypsin deficiency. (12003388)
2002
19
An immunoassay for canine pancreatic elastase 1 as an indicator for exocrine pancreatic insufficiency in dogs. (11724136)
2001
20
Stimulation of immunoglobulin E formation in chronic pancreatitis by alcohol drinking and exocrine pancreatic insufficiency]. (11367975)
2001
21
Exocrine pancreatic insufficiency caused by a somatostatinoma of the minor and major duodenal papilla in a patient with neurofibromatosis. (11266260)
2001
22
Analysis of exocrine pancreatic function in cystic fibrosis: one mild CFTR mutation does not exclude pancreatic insufficiency. (11589722)
2001
23
A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency. (10950038)
2000
24
What to do when a patient with exocrine pancreatic insufficiency does not respond to pancreatic enzyme substitution, a practical guide. (10026441)
1999
25
A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency. (10383531)
1999
26
Serum trypsinlike immunoreactivity measurement for the diagnosis of subclinical exocrine pancreatic insufficiency. (10499725)
1999
27
False-positive gliadin and endomysium antibodies and exocrine pancreatic insufficiency as pitfalls in the differential diagnosis of duodenal Crohn's versus celiac disease. (9672361)
1998
28
Gene therapy for exocrine pancreatic insufficiency. (8194722)
1994
29
Effect of treatment on the jejunal and colonic bacterial flora of dogs with exocrine pancreatic insufficiency. (8302792)
1993
30
Diabetes mellitus and exocrine pancreatic insufficiency in a girl with auto-immune haemolysis. (1628669)
1992
31
Ichthyosis, exocrine pancreatic insufficiency, impaired neutrophil chemotaxis, growth retardation, and metaphyseal dysplasia. (1892416)
1991
32
Fecal proteolytic activity in clinically normal cats and in a cat with exocrine pancreatic insufficiency. (2117001)
1990
33
Mesenteric torsion in dogs with exocrine pancreatic insufficiency: 21 cases (1978-1987). (2584106)
1989
34
Effect of exocrine pancreatic insufficiency on cobalamin absorption in dogs. (2782706)
1989
35
More on exocrine pancreatic insufficiency. (2917887)
1989
36
Digestive and absorptive phase anomalies associated with the exocrine pancreatic insufficiency of cystic fibrosis. (3042936)
1988
37
Sensitivity and specificity of radioimmunoassay of serum trypsin-like immunoreactivity for the diagnosis of canine exocrine pancreatic insufficiency. (3258306)
1988
38
Critical examination of therapeutic efficacy of a pH-sensitive enteric-coated pancreatic enzyme preparation in treatment of exocrine pancreatic insufficiency secondary to cystic fibrosis. (3168696)
1988
39
Pancreolauryl and NBT-PABA tests. Are serum tests more practicable alternatives to urine tests in the diagnosis of exocrine pancreatic insufficiency? (3484456)
1986
40
Transient exocrine pancreatic insufficiency in infancy. (6550633)
1983
41
Relationships between serum lipids and malabsorption of bile acids, neutral sterols, and fats in exocrine pancreatic insufficiency. (7433914)
1980
42
The intraluminal transport of vitamin B12 and the exocrine pancreatic insufficiency. (450901)
1979
43
PABA-test for diagnosis of exocrine pancreatic insufficiency. (309936)
1979
44
Effect of exchange exocrine pancreatic insufficiency on small intestine in the mouse. (206483)
1978
45
Diagnosis of exocrine pancreatic insufficiency in cystic fibrosis by the synthetic peptide N-benzoyl-L-tyrosyl-p-aminobenzoic acid. (305953)
1978
46
Enzyme replacement therapy of exocrine pancreatic insufficiency in man. Relations between in vitro enzyme activities and in vivo potency in commercial pancreatic extracts. (16212)
1977
47
Electron microscopic examination of cartilage in the syndrome of exocrine pancreatic insufficiency, neutropenia, metaphyseal dysostosis and dwarfism. (4141701)
1974
48
Lundh test in the diagnosis of exocrine pancreatic insufficiency. (4763950)
1973
49
Exocrine pancreatic insufficiency: a new recessive mutation in mice. (4782672)
1973
50
Synthetic peptides in the diagnosis of exocrine pancreatic insufficiency in animals. (4639406)
1972

Genetic Variations for Exocrine Pancreatic Insufficiency

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Expression for genes affiliated with Exocrine Pancreatic Insufficiency

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Exocrine Pancreatic Insufficiency

Search GEO for disease gene expression data for Exocrine Pancreatic Insufficiency.

Pathways for genes affiliated with Exocrine Pancreatic Insufficiency

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7GIF, PRSS3
29.6CEL, PNLIP, CLPS
3
Hide members
9.6CLPS, PNLIP, CEL
49.6CLPS, PNLIP, CEL
59.3MEP1B, PRSS3, CELA3B
69.3PNLIP, ABHD6
78.8PRSS3, CFTR, PNLIP, CELA3B, CEL

Compounds for genes affiliated with Exocrine Pancreatic Insufficiency

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44Novoseek, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1epft4410.5CCK, SCT
2l-bpa4410.5SCT, CCK
3h2dids4410.5CFTR, SCT
4caerulein4410.5CCK, SCT
5pancreozymin4410.4CCK, SCT
6saccharin44 211.4CCK, ELANE
7Mdl 101,1461110.4CELA1, ELANE
8loxiglumide4410.4CCK, SCT
9ethylenediamine4410.4CEL, ELANE
10ONO-68181110.4CELA1, ELANE
11pepsinogen4410.3CCK, SCT
12cerulein4410.3ELANE, SCT, CCK
13olestra4410.3PNLIP, CCK
14METHOXYUNDECYLPHOSPHINIC ACID1110.3CLPS, PNLIP
15taurodeoxycholate4410.3CCK, SCT, CLPS
16p-nitrophenyl acetate4410.3PNLIP, CEL
17(Hydroxyethyloxy)Tri(Ethyloxy)Octane1110.2PNLIP, CLPS
18pristimerin5910.2PNLIP, CEL
19gsk 264220a5910.2PNLIP, CEL
20jzl 1845910.2PNLIP, CEL
21lactulose4410.2CD79A, CCK
22enterostatin4410.2CCK, CLPS
23nppb44 59 2812.1CFTR, SCT
24cholic acid44 28 11 2413.1COX4I1, PNLIP, CEL
25vancomycin44 1111.1CD79A, ELANE
26carbachol44 28 1111.9CCK, SCT, CD79A, CFTR
27octreotide44 59 28 1112.9CCK, SCT, PNLIP, ELANE
28oleic acid44 28 11 2412.9SCT, PNLIP, CEL
29chloroquine44 2 49 28 1113.9CEL, CFTR, CD79A
30norepinephrine44 11 2411.9CCK, CFTR, PNLIP, ELANE
31triacylglycerol449.9CEL, PNLIP, CLPS
32orlistat44 59 1111.9CEL, PNLIP, CLPS, CCK
33aspirin44 49 28 2412.9ELANE, CFTR, CD79A, CCK
34azithromycin44 1110.8CFTR, CD79A
35epinephrine44 11 2411.8SCT, CD79A, CFTR, ELANE
36acetylcholine44 49 28 11 2413.7CCK, SCT, CD79A, CFTR, ELANE
37taurocholate449.7CCK, SCT, CFTR, PNLIP, CEL
38bicarbonate449.7CCK, SCT, CFTR, PNLIP, CEL
39adenylate449.7CCK, SCT, CFTR, CEL, ELANE
40cyclosporin a44 28 5911.7CCK, SCT, CD79A, CFTR, ELANE
41pge2449.7ELANE, CFTR, CD79A, SCT, CCK
42phosphatidylcholine449.7CD79A, CLPS, PNLIP, CEL
43phospholipid449.6COX4I1, SCT, CLPS, PNLIP, CEL
44thyroxine44 2410.6SCT, PRSS3, CD79A, ELANE
45glycerol44 11 2411.6CCK, CD79A, CFTR, PNLIP, CEL
46polysaccharide449.6CEL, CD79A, MEP1B, CCK
47biotin44 11 2411.4CFTR, CD79A, SCT
48testosterone44 59 11 2412.3CCK, SCT, CD79A, CFTR, ELANE
49glutamate449.3CCK, SCT, CD79A, CFTR, PNLIP, ELANE
50trypsinogen449.2ELANE, PNLIP, CFTR, PRSS3, SCT, CCK

GO Terms for genes affiliated with Exocrine Pancreatic Insufficiency

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16Gene Ontology
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Cellular components related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.1ELANE, SCT, PPY, PRSS3, GIF, CLPS

Biological processes related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pancreatic juice secretionGO:03015710.2CEL, SCT
2intestinal cholesterol absorptionGO:0302999.8CEL, PNLIP
3lipid digestionGO:0442419.8CEL, PNLIP, CLPS
4cobalamin metabolic processGO:0092359.7GIF, PRSS3
5digestionGO:0075869.4PPY, MEP1B, PRSS3
6proteolysisGO:0065088.8MEP1B, PRSS3, CELA3B, CELA1, ELANE
7small molecule metabolic processGO:0442817.7COX4I1, PRSS3, GIF, EPT1, CLPS, PNLIP

Molecular functions related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride lipase activityGO:0048069.9CEL, PNLIP
2acylglycerol lipase activityGO:0473729.4ABHD6, CEL
3hormone activityGO:0051799.3PPY, SCT, CCK
4serine-type endopeptidase activityGO:0042529.1ELANE, CELA1, CELA3B, PRSS3

Products for genes affiliated with Exocrine Pancreatic Insufficiency

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  • Antibodies
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Sources for Exocrine Pancreatic Insufficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet