MCID: EXC002
MIFTS: 47

Exocrine Pancreatic Insufficiency malady

Endocrine diseases category

Summaries for Exocrine Pancreatic Insufficiency

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63Wikipedia, 32MalaCards
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Wikipedia:63 Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of... more...

MalaCards: Exocrine Pancreatic Insufficiency is related to pancreatitis and cystic fibrosis. An important gene associated with Exocrine Pancreatic Insufficiency is COX4I2 (cytochrome c oxidase subunit IV isoform 2 (lung)), and among its related pathways are Cobalamin (Cbl, vitamin B12) transport and metabolism and Digestion of dietary lipid. The compounds epft and l-bpa have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreas and small intestine, and related mouse phenotypes are digestive/alimentary and growth/size.

Aliases & Classifications for Exocrine Pancreatic Insufficiency

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

exocrine pancreatic insufficiency 8 10 44 60


External Ids:

Disease Ontology8 DOID:13316
MeSH34 D010188
SNOMED-CT56 47367009
NCIt39 C84316

Related Diseases for Exocrine Pancreatic Insufficiency

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17GeneCards, 18GeneDecks
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Diseases related to Exocrine Pancreatic Insufficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 68)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis32.0PPY, PRSS3, CLPS, CFTR, PNLIP, CELA3B
2cystic fibrosis31.2SCT, CFTR, PNLIP, CELA3B, CELA1, ELANE
3diabetes mellitus31.1CD79A, PPY, SCT, CCK
4pancreatic steatorrhea30.7CELA1, CELA3B, PNLIP
5steatorrhea30.7CCK, SCT, CLPS, CFTR, PNLIP, CELA3B
6alcoholic pancreatitis30.5CCK, SCT, CFTR, ELANE
7irritable bowel syndrome30.3CCK
8respiratory failure30.2CFTR, CCK
9obesity30.2CCK, CLPS, PNLIP
10gastritis30.2CCK, SCT, GIF, CD79A
11duodenitis10.5
12shwachman-diamond syndrome10.5
13exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.5
14type 1 diabetes mellitus10.4
15neurofibromatosis10.3
16somatostatinoma10.3
17pancreatic somatostatinoma10.3
18celiac disease10.3
19duodenal somatostatinoma10.3
20dysostosis10.3
21metaphyseal dysplasia10.3
22neutropenia10.3
23dwarfism10.3
24crohn's disease10.2
25atrophic gastritis10.2
26autoimmune thyroiditis10.2
27cutis laxa10.2
28tropical sprue10.2
29autoimmune hepatitis10.2
30anorexia nervosa10.2
31addison's disease10.2
32hepatitis a10.2
33adenocarcinoma10.2
34diabetic neuropathy10.2
35duodenal disease10.2
36hepatitis10.2
37hyperostosis10.2
38lactic acidosis10.2
39neuropathy10.2
40thyroiditis10.2
41protein-energy malnutrition10.0CCK
42intestinal obstruction10.0CFTR
43cholesterol ester storage disease10.0PNLIP
44cholangitis10.0CFTR
45pustulosis palmaris et plantaris10.0ELANE
46recurrent acute pancreatitis10.0CFTR, SCT
47duodenogastric reflux10.0CCK
48hypoglycemia10.0PPY, SCT
49vipoma10.0SCT
50peptic ulcer10.0SCT, CCK

Graphical network of the top 20 diseases related to Exocrine Pancreatic Insufficiency:



Diseases related to exocrine pancreatic insufficiency

Clinical Features for Exocrine Pancreatic Insufficiency

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Drugs & Therapeutics for Exocrine Pancreatic Insufficiency

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Exocrine Pancreatic Insufficiency

Drug clinical trials:

Search ClinicalTrials for Exocrine Pancreatic Insufficiency

Search NIH Clinical Center for Exocrine Pancreatic Insufficiency

Search CenterWatch for Exocrine Pancreatic Insufficiency

Genetic Tests for Exocrine Pancreatic Insufficiency

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Anatomical Context for Exocrine Pancreatic Insufficiency

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Exocrine Pancreatic Insufficiency:

32
Testes, Pancreas, Small intestine, Colon, Liver, Bone, Thyroid, Salivary gland, Skin, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Exocrine Pancreatic Insufficiency:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic AciniAcinar Cells Potential therapeutic candidate, affected by disease

Animal Models for Exocrine Pancreatic Insufficiency or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Exocrine Pancreatic Insufficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5UBR1, CLPS, SBDS, CFTR, PNLIP, CEL
2MP:00053787.9UBR1, PPY, MEP1B, CLPS, SBDS, CFTR
3MP:00053767.3ELANE, COX4I2, CCK, UBR1, SCT, MEP1B

Publications for Exocrine Pancreatic Insufficiency

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50PubMed
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Articles related to Exocrine Pancreatic Insufficiency:

(show top 50)    (show all 236)
idTitleAuthorsYear
1
Low prevalence of exocrine pancreatic insufficiency in patients with diabetes mellitus. (23890131)
2013
2
Screening and risk factors of exocrine pancreatic insufficiency in critically ill adult patients receiving enteral nutrition. (23924602)
2013
3
The growing pancreatic duct ligated pig as a model for exocrine pancreatic insufficiency in children: investigations to achieve sufficient vitamin A and vitamin E supply. (23365367)
2012
4
Behavioral changes in response to feeding pancreatic-like enzymes to exocrine pancreatic insufficiency pigs. (23365403)
2012
5
Prevalence of exocrine pancreatic insufficiency in women with obesity syndrome: assessment by pancreatic fecal elastase 1. (22111014)
2011
6
Efficacy and safety of PANCREAZEAr for treatment of exocrine pancreatic insufficiency due to cystic fibrosis. (21632288)
2011
7
Increased postprandial response of glucagon-like peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency. (20460948)
2010
8
CREON (Pancrelipase Delayed-Release Capsules) for the treatment of exocrine pancreatic insufficiency. (21086085)
2010
9
Suppressed glucose metabolism in acinar cells might contribute to the development of exocrine pancreatic insufficiency in streptozotocin-induced diabetic mice. (20051281)
2010
10
Systematic review: efficacy and safety of pancreatic enzyme supplements for exocrine pancreatic insufficiency. (19804466)
2010
11
Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency. (19835990)
2010
12
Efficacy and Safety of a New Formulation of Pancrelipase (Ultrase MT20) in the Treatment of Malabsorption in Exocrine Pancreatic Insufficiency in Cystic Fibrosis. (21197074)
2010
13
An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency. (19297056)
2009
14
Juvenile diabetes mellitus accompanied by exocrine pancreatic insufficiency in a dog. (19122401)
2008
15
Effects of diet on clinical signs of exocrine pancreatic insufficiency in dogs. (16426193)
2006
16
Fecal pancreatic elastase: a reproducible marker for severe exocrine pancreatic insufficiency. (17048055)
2006
17
Exocrine pancreatic insufficiency in dogs. (14552166)
2003
18
Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dogs. (12866928)
2003
19
The commercially available ELISA for pancreatic elastase 1 based on polyclonal antibodies does measure an as yet unknown antigen different from purified elastase 1. Binding studies and clinical use in patients with exocrine pancreatic insufficiency. (13130326)
2003
20
Oral bleeding associated with pancreatic enzyme supplementation in three dogs with exocrine pancreatic insufficiency. (12494968)
2002
21
Serum vitamin A concentration in dogs with experimentally induced exocrine pancreatic insufficiency. (12098886)
2002
22
Gastric acid suppression and treatment of severe exocrine pancreatic insufficiency. (11403540)
2001
23
Faecal elastase 1: a marker of exocrine pancreatic insufficiency in cystic fibrosis. (10586310)
1999
24
Response to long-term enzyme replacement treatment in dogs with exocrine pancreatic insufficiency. (9656030)
1998
25
Faecal elastase 1: not helpful in diagnosing chronic pancreatitis associated with mild to moderate exocrine pancreatic insufficiency. (9616319)
1998
26
Exocrine pancreatic insufficiency. (8677627)
1996
27
Maldigestion associated with exocrine pancreatic insufficiency: implications of gastrointestinal physiology and properties of enzyme preparations for a cause-related and patient-tailored treatment. (7661155)
1995
28
Is the plasma amino acid consumption test an accurate test of exocrine pancreatic insufficiency? (8299915)
1994
29
Exocrine pancreatic insufficiency. (8503162)
1993
30
Ichthyosis, exocrine pancreatic insufficiency, impaired neutrophil chemotaxis, growth retardation, and metaphyseal dysplasia (Shwachman syndrome). Report of a case with extensive skin lesions (clinical, histological, and ultrastructural findings) (1990988)
1991
31
Exocrine pancreatic insufficiency-like syndrome in giraffe. (1721936)
1991
32
High serum trypsin-like immunoreactivity secondary to pancreatitis in a dog with exocrine pancreatic insufficiency. (2105925)
1990
33
Monitoring enzyme replacement treatment in exocrine pancreatic insufficiency using the cholesteryl octanoate breath test. (2253920)
1990
34
Effects of exocrine pancreatic insufficiency and replacement therapy on the bacterial flora of the duodenum in dogs. (2301831)
1990
35
Enzyme therapy for malabsorption in exocrine pancreatic insufficiency. (2668933)
1989
36
Exocrine pancreatic insufficiency in syndromic paucity of interlobular bile ducts. (2621522)
1989
37
Hypothesis: Shwachman's syndrome of exocrine pancreatic insufficiency may be caused by neonatal copper deficiency. (3190162)
1988
38
Role of nonpancreatic lipolytic activity in exocrine pancreatic insufficiency. (3781179)
1987
39
Serum PP-release after hormonal (CCK) and mixed test-meal (MTM) stimulation by children with exocrine pancreatic insufficiency (EPI). (3807430)
1986
40
Diagnosis of exocrine pancreatic insufficiency in cystic fibrosis by use of fluorescein dilaurate test. (3729527)
1986
41
The bentiromide test for pancreatic exocrine insufficiency. (6371722)
1984
42
Quantitative assessment of fat absorption and its diagnostic value in exocrine pancreatic insufficiency. (6635347)
1983
43
Comparative evaluation of the therapeutic efficacy of a pH-sensitive enteric coated pancreatic enzyme preparation with conventional pancreatic enzyme therapy in the treatment of exocrine pancreatic insufficiency. (6549746)
1983
44
Controversies in the treatment of exocrine pancreatic insufficiency. (6919479)
1982
45
Exocrine pancreatic insufficiency in celiac sprue. (7202960)
1981
46
A new test for the diagnosis of exocrine pancreatic insufficiency in the dog. (311393)
1979
47
Trace element malabsorption in exocrine pancreatic insufficiency. (460284)
1979
48
Exocrine pancreatic insufficiency and primitive malnutrition. (838182)
1977
49
Utilization of enzymatically hydrolyzed soybean protein and crystalline amino acid diets by rats with exocrine pancreatic insufficiency. (4857343)
1974
50
Protein content and pancreatic enzyme activities of duodenal juice in normal children and in children with exocrine pancreatic insufficiency. (4975784)
1968

Genetic Variations for Exocrine Pancreatic Insufficiency

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Expression for genes affiliated with Exocrine Pancreatic Insufficiency

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Exocrine Pancreatic Insufficiency

Search GEO for disease gene expression data for Exocrine Pancreatic Insufficiency.

Pathways for genes affiliated with Exocrine Pancreatic Insufficiency

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53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7GIF, PRSS3
29.6CEL, PNLIP, CLPS
3
Hide members
9.6CLPS, PNLIP, CEL
49.6CLPS, PNLIP, CEL
59.3MEP1B, PRSS3, CELA3B
69.3PNLIP, ABHD6
78.8PRSS3, CFTR, PNLIP, CELA3B, CEL

Compounds for genes affiliated with Exocrine Pancreatic Insufficiency

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44Novoseek, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1epft4410.5SCT, CCK
2l-bpa4410.5CCK, SCT
3h2dids4410.5SCT, CFTR
4caerulein4410.5SCT, CCK
5saccharin44 211.4ELANE, CCK
6pancreozymin4410.4CCK, SCT
7ethylenediamine4410.4CEL, ELANE
8ONO-68181110.4ELANE, CELA1
9Mdl 101,1461110.4CELA1, ELANE
10loxiglumide4410.4CCK, SCT
11pepsinogen4410.3SCT, CCK
12cerulein4410.3SCT, ELANE, CCK
13olestra4410.3PNLIP, CCK
14taurodeoxycholate4410.3CCK, CLPS, SCT
15METHOXYUNDECYLPHOSPHINIC ACID1110.3CLPS, PNLIP
16p-nitrophenyl acetate4410.3PNLIP, CEL
17(Hydroxyethyloxy)Tri(Ethyloxy)Octane1110.2PNLIP, CLPS
18pristimerin5910.2PNLIP, CEL
19gsk 264220a5910.2CEL, PNLIP
20jzl 1845910.2PNLIP, CEL
21lactulose4410.2CD79A, CCK
22enterostatin4410.2CCK, CLPS
23nppb44 59 2812.1CFTR, SCT
24cholic acid44 28 11 2413.1COX4I1, CEL, PNLIP
25vancomycin44 1111.1CD79A, ELANE
26carbachol44 28 1111.9CD79A, SCT, CFTR, CCK
27octreotide44 59 28 1112.9CCK, SCT, ELANE, PNLIP
28oleic acid44 28 11 2412.9CEL, PNLIP, SCT
29chloroquine44 2 49 28 1113.9CFTR, CD79A, CEL
30norepinephrine44 11 2411.9CCK, PNLIP, ELANE, CFTR
31triacylglycerol449.9CEL, CLPS, PNLIP
32orlistat44 59 1111.9CCK, CLPS, PNLIP, CEL
33aspirin44 49 28 2412.9CD79A, CCK, ELANE, CFTR
34azithromycin44 1110.8CFTR, CD79A
35epinephrine44 11 2411.8ELANE, CFTR, CD79A, SCT
36acetylcholine44 49 28 11 2413.7ELANE, CCK, SCT, CD79A, CFTR
37taurocholate449.7PNLIP, CFTR, SCT, CEL, CCK
38bicarbonate449.7CFTR, SCT, CCK, CEL, PNLIP
39adenylate449.7SCT, ELANE, CEL, CFTR, CCK
40cyclosporin a44 28 5911.7SCT, CD79A, CCK, CFTR, ELANE
41pge2449.7ELANE, CCK, SCT, CD79A, CFTR
42phosphatidylcholine449.7CEL, PNLIP, CLPS, CD79A
43phospholipid449.6CEL, PNLIP, CLPS, COX4I1, SCT
44thyroxine44 2410.6PRSS3, CD79A, ELANE, SCT
45glycerol44 11 2411.6CCK, CFTR, CD79A, PNLIP, CEL
46polysaccharide449.6CEL, CD79A, MEP1B, CCK
47biotin44 11 2411.4SCT, CFTR, CD79A
48testosterone44 59 11 2412.3CCK, ELANE, SCT, CD79A, CFTR
49glutamate449.3ELANE, PNLIP, CD79A, SCT, CCK, CFTR
50trypsinogen449.2SCT, ELANE, PNLIP, CFTR, PRSS3, CCK

GO Terms for genes affiliated with Exocrine Pancreatic Insufficiency

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16Gene Ontology
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Cellular components related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.1ELANE, SCT, PPY, PRSS3, GIF, CLPS

Biological processes related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pancreatic juice secretionGO:03015710.2CEL, SCT
2intestinal cholesterol absorptionGO:0302999.8CEL, PNLIP
3lipid digestionGO:0442419.8CEL, PNLIP, CLPS
4cobalamin metabolic processGO:0092359.7GIF, PRSS3
5digestionGO:0075869.4PPY, MEP1B, PRSS3
6proteolysisGO:0065088.8MEP1B, PRSS3, CELA3B, CELA1, ELANE
7small molecule metabolic processGO:0442817.7COX4I1, PRSS3, GIF, EPT1, CLPS, PNLIP

Molecular functions related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride lipase activityGO:0048069.9CEL, PNLIP
2acylglycerol lipase activityGO:0473729.4ABHD6, CEL
3hormone activityGO:0051799.3PPY, SCT, CCK
4serine-type endopeptidase activityGO:0042529.1ELANE, CELA1, CELA3B, PRSS3

Products for genes affiliated with Exocrine Pancreatic Insufficiency

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  • Antibodies
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Sources for Exocrine Pancreatic Insufficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet