MCID: EXC002
MIFTS: 49

Exocrine Pancreatic Insufficiency malady

Endocrine diseases category

Summaries for Exocrine Pancreatic Insufficiency

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66Wikipedia, 34MalaCards
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Wikipedia:66 Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of... more...

MalaCards: Exocrine Pancreatic Insufficiency is related to pancreatitis and cystic fibrosis. An important gene associated with Exocrine Pancreatic Insufficiency is COX4I2 (cytochrome c oxidase subunit IV isoform 2 (lung)), and among its related pathways are AMPK Enzyme Complex Pathway and Pancreatic secretion. The compounds epft and l-bpa have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreas and small intestine, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Exocrine Pancreatic Insufficiency

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

exocrine pancreatic insufficiency 9 11 46 63


External Ids:

Disease Ontology9 DOID:13316
MeSH36 D010188
SNOMED-CT59 47367009
NCIt41 C84316

Related Diseases for Exocrine Pancreatic Insufficiency

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18GeneCards, 19GeneDecks
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Diseases related to Exocrine Pancreatic Insufficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.9PPY, PNLIP, CFTR, SCT, ELANE, CELA3B
2cystic fibrosis31.3SCT, ELANE, CELA1, CELA3B, CFTR, PNLIP
3diabetes mellitus31.1PDX1, PPY, CD79A, CCK, SCT
4steatorrhea30.7CCK, CELA1, CELA3B, ELANE, SCT, CFTR
5type 1 diabetes mellitus30.7SCT, PDX1, CD79A
6gastritis30.4SCT, CCK, CD79A
7adenocarcinoma30.3CCK, PNLIP, CEL, SCT, PDX1
8duodenitis10.5
9shwachman-diamond syndrome10.5
10exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.5
11blindness10.5
12neurofibromatosis10.4
13celiac disease10.4
14somatostatinoma10.4
15dysostosis10.4
16metaphyseal dysplasia10.4
17neutropenia10.4
18dwarfism10.4
19atrophic gastritis10.2
20tropical sprue10.2
21autoimmune hepatitis10.2
22irritable bowel syndrome10.2
23anorexia nervosa10.2
24duodenal somatostatinoma10.2
25addison's disease10.2
26cutis laxa10.2
27diabetic neuropathy10.2
28hepatitis10.2
29hyperostosis10.2
30lactic acidosis10.2
31neuropathy10.2
32obesity10.2
33respiratory failure10.2
34thyroiditis10.2
35calvarial hyperostosis10.2
36duodenogastric reflux10.1CCK
37keratoconjunctivitis sicca10.1CFTR
38pustulosis palmaris et plantaris10.1ELANE
39recurrent acute pancreatitis10.1CFTR, SCT
40giardiasis10.1CD79A
41gallbladder disease10.1CCK, CFTR
42conjunctivitis10.1CD79A
43prostatitis10.1CD79A
44cystic kidney10.1CFTR, SCT
45aspergillosis10.1CD79A, ELANE
46duodenal ulcer10.1PPY, SCT, CCK
47pancreatic cancer10.1SCT, CCK, CEL
48emphysema due to aat deficiency10.1ELANE
49alcoholic pancreatitis10.0ELANE, CFTR, CCK, SCT
50pancreatic steatorrhea10.0PNLIP, CELA3B, CELA1

Graphical network of the top 20 diseases related to Exocrine Pancreatic Insufficiency:



Diseases related to exocrine pancreatic insufficiency

Symptoms for Exocrine Pancreatic Insufficiency

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Drugs & Therapeutics for Exocrine Pancreatic Insufficiency

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Exocrine Pancreatic Insufficiency

Drug clinical trials:

Search ClinicalTrials for Exocrine Pancreatic Insufficiency

Search NIH Clinical Center for Exocrine Pancreatic Insufficiency

Search CenterWatch for Exocrine Pancreatic Insufficiency

Genetic Tests for Exocrine Pancreatic Insufficiency

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Anatomical Context for Exocrine Pancreatic Insufficiency

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Exocrine Pancreatic Insufficiency:

34
Testes, Pancreas, Small intestine, Colon, Liver, Bone, Thyroid, Salivary gland, Skin, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Exocrine Pancreatic Insufficiency:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic AciniAcinar Cells Potential therapeutic candidate, affected by disease

Animal Models for Exocrine Pancreatic Insufficiency or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Exocrine Pancreatic Insufficiency:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6PDX1, SBDS, CEL, CFTR, PNLIP
2MP:00053818.1PNLIP, CFTR, CEL, SBDS, PDX1, UBR1
3MP:00053766.9CD79A, PNLIP, CFTR, SCT, ELANE, CEL
4MP:00053786.9PPY, PNLIP, CFTR, CEL, SBDS, COX4I2

Publications for Exocrine Pancreatic Insufficiency

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53PubMed
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Articles related to Exocrine Pancreatic Insufficiency:

(show top 50)    (show all 223)
idTitleAuthorsYear
1
Low prevalence of exocrine pancreatic insufficiency in patients with diabetes mellitus. (23890131)
2013
2
Biallelic PDX1 (insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency. (23320570)
2013
3
The growing pancreatic duct ligated pig as a model for exocrine pancreatic insufficiency in children: investigations to achieve sufficient vitamin A and vitamin E supply. (23365367)
2012
4
Hyperammonaemia due to cobalamin malabsorption in a cat with exocrine pancreatic insufficiency. (22907395)
2012
5
Prevalence of exocrine pancreatic insufficiency in women with obesity syndrome: assessment by pancreatic fecal elastase 1. (22111014)
2011
6
A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery. (21418260)
2011
7
Evaluation of stool collections to measure efficacy of PERT in subjects with exocrine pancreatic insufficiency. (21681115)
2011
8
Heritability of exocrine pancreatic insufficiency in German Shepherd dogs. (20102502)
2010
9
IBS: Do we need to exclude exocrine pancreatic insufficiency in IBS? (20811362)
2010
10
An online resource for canine exocrine pancreatic insufficiency. (21137601)
2010
11
Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis. (19815466)
2009
12
Pancreatic enzyme replacement therapy: exocrine pancreatic insufficiency after gastrointestinal surgery. (20495625)
2009
13
An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency. (19297056)
2009
14
Predictive factors for exocrine pancreatic insufficiency after pancreatoduodenectomy with pancreaticogastrostomy. (19415402)
2009
15
A case of fulminant type 1 diabetes mellitus with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion. (18789550)
2008
16
Juvenile diabetes mellitus accompanied by exocrine pancreatic insufficiency in a dog. (19122401)
2008
17
Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial. (17103488)
2007
18
Exocrine pancreatic insufficiency in pigeons. (16448944)
2006
19
Effects of diet on clinical signs of exocrine pancreatic insufficiency in dogs. (16426193)
2006
20
Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study. (16036530)
2005
21
Exocrine pancreatic insufficiency and adverse reaction to food in dogs: a positive response to a high-fat, soy isolate hydrolysate-based diet. (15284428)
2004
22
Exocrine pancreatic insufficiency in dogs. (14552166)
2003
23
Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dogs. (12866928)
2003
24
Oral bleeding associated with pancreatic enzyme supplementation in three dogs with exocrine pancreatic insufficiency. (12494968)
2002
25
An immunoassay for canine pancreatic elastase 1 as an indicator for exocrine pancreatic insufficiency in dogs. (11724136)
2001
26
Iron, zinc, and copper concentration in serum, various organs, and hair of dogs with experimentally induced exocrine pancreatic insufficiency. (11478496)
2001
27
Stimulation of immunoglobulin E formation in chronic pancreatitis by alcohol drinking and exocrine pancreatic insufficiency]. (11367975)
2001
28
Serum feline trypsin-like immunoreactivity in cats with exocrine pancreatic insufficiency. (11110385)
2000
29
Detection and follow up of exocrine pancreatic insufficiency in cystic fibrosis: a review. (10968231)
2000
30
Response to long-term enzyme replacement treatment in dogs with exocrine pancreatic insufficiency. (9656030)
1998
31
Exocrine pancreatic insufficiency in celiac disease. (9496962)
1998
32
Intestinal permeability in exocrine pancreatic insufficiency due to cystic fibrosis or chronic pancreatitis. (8725259)
1996
33
Gene therapy for exocrine pancreatic insufficiency. (8194722)
1994
34
Effect of treatment on the jejunal and colonic bacterial flora of dogs with exocrine pancreatic insufficiency. (8302792)
1993
35
Adequate enzymatic substitution in treating exocrine pancreatic insufficiency. (7526630)
1993
36
Diabetes mellitus and exocrine pancreatic insufficiency in a girl with auto-immune haemolysis. (1628669)
1992
37
Ichthyosis, exocrine pancreatic insufficiency, impaired neutrophil chemotaxis, growth retardation, and metaphyseal dysplasia. (1892416)
1991
38
High serum trypsin-like immunoreactivity secondary to pancreatitis in a dog with exocrine pancreatic insufficiency. (2105925)
1990
39
Evaluation of faecal analysis as an aid to the detection of exocrine pancreatic insufficiency. (3382906)
1988
40
Digestive and absorptive phase anomalies associated with the exocrine pancreatic insufficiency of cystic fibrosis. (3042936)
1988
41
Sensitivity and specificity of radioimmunoassay of serum trypsin-like immunoreactivity for the diagnosis of canine exocrine pancreatic insufficiency. (3258306)
1988
42
Enteropeptidase (EC 3.4.21.9) in coeliac disease and exocrine pancreatic insufficiency. (2962436)
1987
43
Exocrine pancreatic insufficiency and idiopathic haemochromatosis. (6494088)
1984
44
Evaluation of serum pancreatic polypeptide estimations following hormonal stimulation for the diagnosis of exocrine pancreatic insufficiency. (6510573)
1984
45
Quantitative assessment of fat absorption and its diagnostic value in exocrine pancreatic insufficiency. (6635347)
1983
46
Comparative evaluation of the therapeutic efficacy of a pH-sensitive enteric coated pancreatic enzyme preparation with conventional pancreatic enzyme therapy in the treatment of exocrine pancreatic insufficiency. (6549746)
1983
47
Specificity of the BT-PABA test for the diagnosis of exocrine pancreatic insufficiency in the dog. (6972120)
1981
48
The intraluminal transport of vitamin B12 and the exocrine pancreatic insufficiency. (450901)
1979
49
Exocrine pancreatic insufficiency syndrome in CBA/J mice. III. Pathological and genetic analysis. (873127)
1977
50
Electron microscopic examination of cartilage in the syndrome of exocrine pancreatic insufficiency, neutropenia, metaphyseal dysostosis and dwarfism. (4141701)
1974

Variations for Exocrine Pancreatic Insufficiency

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Expression for genes affiliated with Exocrine Pancreatic Insufficiency

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Exocrine Pancreatic Insufficiency

Search GEO for disease gene expression data for Exocrine Pancreatic Insufficiency.

Pathways for genes affiliated with Exocrine Pancreatic Insufficiency

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51PathCards, 54QIAGEN, 31KEGG
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Pathways related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7COX4I1, COX4I2, CFTR
28.8CEL, CELA3B, CFTR, PNLIP

Compounds for genes affiliated with Exocrine Pancreatic Insufficiency

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46Novoseek, 3BitterDB, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB
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Compounds related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1epft4610.4CCK, SCT
2l-bpa4610.4SCT, CCK
3taurodeoxycholate4610.4SCT, CCK
4caerulein4610.4CCK, SCT
5pancreozymin4610.4CCK, SCT
6h2dids4610.4SCT, CFTR
7saccharin46 311.3CCK, ELANE
8loxiglumide4610.3SCT, CCK
9ethylenediamine4610.3ELANE, CEL
10pepsinogen4610.3CCK, SCT
11cerulein4610.2ELANE, CCK, SCT
12olestra4610.1CCK, PNLIP
13lactulose4610.1CD79A, CCK
14vancomycin46 1211.1CD79A, ELANE
15p-nitrophenyl acetate4610.0PNLIP, CEL
16jzl 1846210.0CEL, PNLIP
17gsk 264220a6210.0CEL, PNLIP
18pristimerin6210.0CEL, PNLIP
19c-peptide469.9PDX1, SCT, CCK
20orlistat46 62 1211.9CCK, CEL, PNLIP
21incretin469.8PDX1, CCK
22chloroquine46 3 52 30 1213.8CEL, CFTR, CD79A
23azithromycin46 1210.8CFTR, CD79A
24biotin46 25 1211.8SCT, CFTR, CD79A
25caffeine46 30 3 52 25 1214.8CFTR, CCK, ELANE
26carbachol46 30 1211.8SCT, CFTR, CCK, CD79A
27cholic acid46 30 25 1212.8CEL, PNLIP, COX4I1
28oleic acid46 30 25 1212.7CEL, SCT, PNLIP
29chlorine46 2510.7CFTR, ELANE, CD79A
30aspirin46 52 30 2512.7CD79A, CFTR, ELANE, CCK
31epinephrine46 25 1211.7CD79A, ELANE, SCT, CFTR
32octreotide46 62 30 1212.7ELANE, SCT, PNLIP, CCK
33glutamine469.6CCK, CFTR, SCT, ELANE
34adenylate469.6CFTR, SCT, ELANE, CEL, CCK
35acetylcholine46 52 30 25 1213.5CCK, CD79A, ELANE, CFTR, SCT
36cyclosporin a46 30 6211.5CCK, ELANE, SCT, CFTR, CD79A
37pge2469.5SCT, ELANE, CCK, CD79A, CFTR
38forskolin46 52 1211.5CFTR, CCK, PDX1, SCT
39testosterone46 62 25 1212.5CD79A, SCT, CFTR, ELANE, CCK
40phospholipid469.4CEL, COX4I1, PNLIP, SCT
41trypsinogen469.4CCK, ELANE, SCT, CFTR, PNLIP
42taurocholate469.4CCK, SCT, CFTR, PNLIP, CEL
43bicarbonate469.4CEL, CFTR, SCT, PNLIP, CCK
44glycerol46 25 1211.2CFTR, CEL, CCK, PNLIP, CD79A
45dopamine46 30 25 1212.0CFTR, SCT, CD79A, CCK
46retinoic acid46 2510.0CD79A, SCT, PDX1, CCK, ELANE, CFTR
47norepinephrine46 25 1211.0CD79A, CCK, ELANE, PNLIP, SCT, CFTR
48glutamate469.0CD79A, CCK, ELANE, SCT, CFTR, PNLIP
49oxygen46 259.9ELANE, CEL, COX4I2, PNLIP, COX4I1
50serine468.4PNLIP, SCT, ELANE, CEL, PDX1, CFTR

GO Terms for genes affiliated with Exocrine Pancreatic Insufficiency

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17Gene Ontology
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Cellular components related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8CCK, CEL, CELA1, ELANE, SCT, PNLIP

Biological processes related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pancreatic juice secretionGO:03015710.0SCT, CEL
2hydrogen ion transmembrane transportGO:19026009.9COX4I1, COX4I2
3lipid digestionGO:0442419.8CEL, PNLIP
4generation of precursor metabolites and energyGO:0060919.6PDX1, COX4I1, COX4I2
5intestinal cholesterol absorptionGO:0302999.6CEL, PNLIP
6exocrine pancreas developmentGO:0310179.4PDX1, CELA1

Molecular functions related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride lipase activityGO:0048069.4CEL, PNLIP
2serine-type endopeptidase activityGO:0042529.3CELA1, CELA3B, ELANE
3hormone activityGO:0051799.1CCK, SCT, PPY

Products for genes affiliated with Exocrine Pancreatic Insufficiency

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Sources for Exocrine Pancreatic Insufficiency

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet