MCID: EXC002
MIFTS: 48

Exocrine Pancreatic Insufficiency malady

Endocrine diseases category

Summaries for Exocrine Pancreatic Insufficiency

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Wikipedia:64 Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack of... more...

MalaCards based summary: Exocrine Pancreatic Insufficiency is related to pancreatitis and cystic fibrosis. An important gene associated with Exocrine Pancreatic Insufficiency is COX4I2 (cytochrome c oxidase subunit IV isoform 2 (lung)), and among its related pathways are AMPK Enzyme Complex Pathway and Pancreatic secretion. The compounds epft and l-bpa have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and small intestine, and related mouse phenotypes are liver/biliary system and digestive/alimentary.

Aliases & Classifications for Exocrine Pancreatic Insufficiency

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Exocrine Pancreatic Insufficiency, Aliases & Descriptions:

Name: Exocrine Pancreatic Insufficiency 31 9 11 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:13316
NCIt39 C84316
SNOMED-CT56 47367009
MeSH34 D010188

Related Diseases for Exocrine Pancreatic Insufficiency

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Diseases related to Exocrine Pancreatic Insufficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.4PNLIP, PPY, CFTR, SCT, ELANE, CELA3B
2cystic fibrosis31.2PNLIP, CFTR, SCT, ELANE, CELA3B, CELA1
3diabetes mellitus30.9PPY, SCT, CCK, PDX1, CD79A
4gastritis30.6SCT, CCK, CD79A
5type 1 diabetes mellitus30.6SCT, PDX1, CD79A
6steatorrhea30.5PNLIP, CCK, CELA1, CELA3B, ELANE, SCT
7adenocarcinoma30.2PNLIP, SCT, CEL, CCK, PDX1
8shwachman-diamond syndrome10.5
9exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis10.5
10duodenitis10.5
11blindness10.5
12duodenogastric reflux10.5CCK
13keratoconjunctivitis sicca10.5CFTR
14neutropenia10.4
15somatostatinoma10.4
16neurofibromatosis10.4
17dysostosis10.4
18metaphyseal dysplasia10.4
19dwarfism10.4
20pustulosis palmaris et plantaris10.4ELANE
21recurrent acute pancreatitis10.4CFTR, SCT
22giardiasis10.3CD79A
23gallbladder disease10.3CCK, CFTR
24conjunctivitis10.3CD79A
25prostatitis10.3CD79A
26cystic kidney10.3SCT, CFTR
27aspergillosis10.3ELANE, CD79A
28duodenal ulcer10.3CCK, SCT, PPY
29pancreatic cancer10.2CCK, CEL, SCT
30autoimmune hepatitis10.2
31celiac disease10.2
32diabetic neuropathy10.2
33hepatitis10.2
34liver disease10.2
35obesity10.2
36irritable bowel syndrome10.2
37duodenal somatostatinoma10.2
38johanson-blizzard syndrome10.2
39addison's disease10.2
40atrophic gastritis10.2
41tropical sprue10.2
42anorexia nervosa10.2
43cutis laxa10.2
44hyperostosis10.2
45lactic acidosis10.2
46neuropathy10.2
47respiratory failure10.2
48thyroiditis10.2
49calvarial hyperostosis10.2
50emphysema due to aat deficiency10.2ELANE

Graphical network of the top 20 diseases related to Exocrine Pancreatic Insufficiency:



Diseases related to exocrine pancreatic insufficiency

Symptoms for Exocrine Pancreatic Insufficiency

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Drugs & Therapeutics for Exocrine Pancreatic Insufficiency

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Drug clinical trials:

Search ClinicalTrials for Exocrine Pancreatic Insufficiency

Search NIH Clinical Center for Exocrine Pancreatic Insufficiency

Genetic Tests for Exocrine Pancreatic Insufficiency

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Anatomical Context for Exocrine Pancreatic Insufficiency

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MalaCards organs/tissues related to Exocrine Pancreatic Insufficiency:

32
Pancreas, Testes, Small intestine, Liver, Neutrophil, Bone marrow, Bone, Colon, Thyroid, Salivary gland, Skin

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Exocrine Pancreatic Insufficiency:
id TissueAnatomical CompartmentCell Relevance
1 PancreasPancreatic AciniAcinar Cells Potential therapeutic candidate, affected by disease

Animal Models for Exocrine Pancreatic Insufficiency or affiliated genes

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MGI Mouse Phenotypes related to Exocrine Pancreatic Insufficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6PDX1, SBDS, CEL, CFTR, PNLIP
2MP:00053818.1PNLIP, CFTR, CEL, SBDS, PDX1, UBR1
3MP:00053766.9CD79A, PNLIP, CFTR, SCT, ELANE, CEL
4MP:00053786.9PPY, PNLIP, CFTR, CEL, SBDS, COX4I2

Publications for Exocrine Pancreatic Insufficiency

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Articles related to Exocrine Pancreatic Insufficiency:

(show top 50)    (show all 230)
idTitleAuthorsYear
1
Case report of exocrine pancreatic insufficiency in two palliative care patients. (24699789)
2014
2
Safety and efficacy of CreonAr Micro in children with exocrine pancreatic insufficiency due to cystic fibrosis. (25066363)
2014
3
Johanson-Blizzard syndrome: expanding the phenotype of exocrine pancreatic insufficiency. (25076350)
2014
4
CTLA-4 +49 and TNF-alpha-308 gene polymorphisms in celiac patients with exocrine pancreatic insufficiency. (24611333)
2013
5
Low prevalence of exocrine pancreatic insufficiency in patients with diabetes mellitus. (23890131)
2013
6
Biallelic PDX1 (insulin promoter factor 1) mutations causing neonatal diabetes without exocrine pancreatic insufficiency. (23320570)
2013
7
The growing pancreatic duct ligated pig as a model for exocrine pancreatic insufficiency in children: investigations to achieve sufficient vitamin A and vitamin E supply. (23365367)
2012
8
Hyperammonaemia due to cobalamin malabsorption in a cat with exocrine pancreatic insufficiency. (22907395)
2012
9
Prevalence of exocrine pancreatic insufficiency in women with obesity syndrome: assessment by pancreatic fecal elastase 1. (22111014)
2011
10
A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery. (21418260)
2011
11
Evaluation of stool collections to measure efficacy of PERT in subjects with exocrine pancreatic insufficiency. (21681115)
2011
12
Heritability of exocrine pancreatic insufficiency in German Shepherd dogs. (20102502)
2010
13
IBS: Do we need to exclude exocrine pancreatic insufficiency in IBS? (20811362)
2010
14
An online resource for canine exocrine pancreatic insufficiency. (21137601)
2010
15
Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis. (19815466)
2009
16
Pancreatic enzyme replacement therapy: exocrine pancreatic insufficiency after gastrointestinal surgery. (20495625)
2009
17
An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency. (19297056)
2009
18
Predictive factors for exocrine pancreatic insufficiency after pancreatoduodenectomy with pancreaticogastrostomy. (19415402)
2009
19
A case of fulminant type 1 diabetes mellitus with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion. (18789550)
2008
20
Juvenile diabetes mellitus accompanied by exocrine pancreatic insufficiency in a dog. (19122401)
2008
21
Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial. (17103488)
2007
22
Exocrine pancreatic insufficiency in pigeons. (16448944)
2006
23
Effects of diet on clinical signs of exocrine pancreatic insufficiency in dogs. (16426193)
2006
24
Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study. (16036530)
2005
25
Exocrine pancreatic insufficiency and adverse reaction to food in dogs: a positive response to a high-fat, soy isolate hydrolysate-based diet. (15284428)
2004
26
Exocrine pancreatic insufficiency in dogs. (14552166)
2003
27
Exocrine pancreatic insufficiency as an end stage of pancreatitis in four dogs. (12866928)
2003
28
Oral bleeding associated with pancreatic enzyme supplementation in three dogs with exocrine pancreatic insufficiency. (12494968)
2002
29
An immunoassay for canine pancreatic elastase 1 as an indicator for exocrine pancreatic insufficiency in dogs. (11724136)
2001
30
Iron, zinc, and copper concentration in serum, various organs, and hair of dogs with experimentally induced exocrine pancreatic insufficiency. (11478496)
2001
31
Stimulation of immunoglobulin E formation in chronic pancreatitis by alcohol drinking and exocrine pancreatic insufficiency]. (11367975)
2001
32
Serum feline trypsin-like immunoreactivity in cats with exocrine pancreatic insufficiency. (11110385)
2000
33
Detection and follow up of exocrine pancreatic insufficiency in cystic fibrosis: a review. (10968231)
2000
34
Response to long-term enzyme replacement treatment in dogs with exocrine pancreatic insufficiency. (9656030)
1998
35
Exocrine pancreatic insufficiency in celiac disease. (9496962)
1998
36
Intestinal permeability in exocrine pancreatic insufficiency due to cystic fibrosis or chronic pancreatitis. (8725259)
1996
37
Effect of treatment on the jejunal and colonic bacterial flora of dogs with exocrine pancreatic insufficiency. (8302792)
1993
38
Adequate enzymatic substitution in treating exocrine pancreatic insufficiency. (7526630)
1993
39
Diabetes mellitus and exocrine pancreatic insufficiency in a girl with auto-immune haemolysis. (1628669)
1992
40
Ichthyosis, exocrine pancreatic insufficiency, impaired neutrophil chemotaxis, growth retardation, and metaphyseal dysplasia. (1892416)
1991
41
High serum trypsin-like immunoreactivity secondary to pancreatitis in a dog with exocrine pancreatic insufficiency. (2105925)
1990
42
Evaluation of faecal analysis as an aid to the detection of exocrine pancreatic insufficiency. (3382906)
1988
43
Enteropeptidase (EC 3.4.21.9) in coeliac disease and exocrine pancreatic insufficiency. (2962436)
1987
44
Exocrine pancreatic insufficiency and idiopathic haemochromatosis. (6494088)
1984
45
Evaluation of serum pancreatic polypeptide estimations following hormonal stimulation for the diagnosis of exocrine pancreatic insufficiency. (6510573)
1984
46
Quantitative assessment of fat absorption and its diagnostic value in exocrine pancreatic insufficiency. (6635347)
1983
47
Comparative evaluation of the therapeutic efficacy of a pH-sensitive enteric coated pancreatic enzyme preparation with conventional pancreatic enzyme therapy in the treatment of exocrine pancreatic insufficiency. (6549746)
1983
48
The intraluminal transport of vitamin B12 and the exocrine pancreatic insufficiency. (450901)
1979
49
Exocrine pancreatic insufficiency syndrome in CBA/J mice. III. Pathological and genetic analysis. (873127)
1977
50
Electron microscopic examination of cartilage in the syndrome of exocrine pancreatic insufficiency, neutropenia, metaphyseal dysostosis and dwarfism. (4141701)
1974

Variations for Exocrine Pancreatic Insufficiency

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Expression for genes affiliated with Exocrine Pancreatic Insufficiency

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Expression patterns in normal tissues for genes affiliated with Exocrine Pancreatic Insufficiency

Search GEO for disease gene expression data for Exocrine Pancreatic Insufficiency.

Pathways for genes affiliated with Exocrine Pancreatic Insufficiency

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Pathways related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7COX4I1, COX4I2, CFTR
28.8CEL, CELA3B, CFTR, PNLIP

Compounds for genes affiliated with Exocrine Pancreatic Insufficiency

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Compounds related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1epft4410.4CCK, SCT
2l-bpa4410.4SCT, CCK
3taurodeoxycholate4410.4SCT, CCK
4caerulein4410.4CCK, SCT
5pancreozymin4410.4CCK, SCT
6h2dids4410.4SCT, CFTR
7saccharin44 311.3CCK, ELANE
8loxiglumide4410.3SCT, CCK
9ethylenediamine4410.3ELANE, CEL
10pepsinogen4410.3CCK, SCT
11cerulein4410.2ELANE, CCK, SCT
12olestra4410.1CCK, PNLIP
13lactulose4410.1CD79A, CCK
14vancomycin44 1211.1CD79A, ELANE
15p-nitrophenyl acetate4410.0PNLIP, CEL
16jzl 1846010.0CEL, PNLIP
17gsk 264220a6010.0CEL, PNLIP
18pristimerin6010.0CEL, PNLIP
19c-peptide449.9PDX1, SCT, CCK
20orlistat44 60 1211.9CCK, CEL, PNLIP
21incretin449.8PDX1, CCK
22chloroquine44 3 50 29 1213.8CEL, CFTR, CD79A
23azithromycin44 1210.8CFTR, CD79A
24biotin44 25 1211.8SCT, CFTR, CD79A
25caffeine44 29 3 50 25 1214.8CFTR, CCK, ELANE
26carbachol44 29 1211.8SCT, CFTR, CCK, CD79A
27cholic acid44 29 25 1212.8CEL, PNLIP, COX4I1
28oleic acid44 29 25 1212.7CEL, SCT, PNLIP
29chlorine44 2510.7CFTR, ELANE, CD79A
30aspirin44 50 29 2512.7CD79A, CFTR, ELANE, CCK
31epinephrine44 25 1211.7CD79A, ELANE, SCT, CFTR
32octreotide44 60 29 1212.7ELANE, SCT, PNLIP, CCK
33glutamine449.6CCK, CFTR, SCT, ELANE
34adenylate449.6CFTR, SCT, ELANE, CEL, CCK
35acetylcholine44 50 29 25 1213.5CCK, CD79A, ELANE, CFTR, SCT
36cyclosporin a44 29 6011.5CCK, ELANE, SCT, CFTR, CD79A
37pge2449.5SCT, ELANE, CCK, CD79A, CFTR
38forskolin44 50 1211.5CFTR, CCK, PDX1, SCT
39testosterone44 60 25 1212.5CD79A, SCT, CFTR, ELANE, CCK
40phospholipid449.4CEL, COX4I1, PNLIP, SCT
41trypsinogen449.4CCK, ELANE, SCT, CFTR, PNLIP
42taurocholate449.4CCK, SCT, CFTR, PNLIP, CEL
43bicarbonate449.4CEL, CFTR, SCT, PNLIP, CCK
44glycerol44 25 1211.2CFTR, CEL, CCK, PNLIP, CD79A
45dopamine44 29 25 1212.0CFTR, SCT, CD79A, CCK
46retinoic acid44 2510.0CD79A, SCT, PDX1, CCK, ELANE, CFTR
47norepinephrine44 25 1211.0CD79A, CCK, ELANE, PNLIP, SCT, CFTR
48glutamate449.0CD79A, CCK, ELANE, SCT, CFTR, PNLIP
49oxygen44 259.9ELANE, CEL, COX4I2, PNLIP, COX4I1
50serine448.4PNLIP, SCT, ELANE, CEL, PDX1, CFTR

GO Terms for genes affiliated with Exocrine Pancreatic Insufficiency

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Cellular components related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8CCK, CEL, CELA1, ELANE, SCT, PNLIP

Biological processes related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pancreatic juice secretionGO:03015710.0CEL, SCT
2hydrogen ion transmembrane transportGO:19026009.9COX4I1, COX4I2
3lipid digestionGO:0442419.8PNLIP, CEL
4generation of precursor metabolites and energyGO:0060919.6PDX1, COX4I1, COX4I2
5intestinal cholesterol absorptionGO:0302999.6PNLIP, CEL
6exocrine pancreas developmentGO:0310179.4PDX1, CELA1

Molecular functions related to Exocrine Pancreatic Insufficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1triglyceride lipase activityGO:0048069.4CEL, PNLIP
2serine-type endopeptidase activityGO:0042529.3CELA1, CELA3B, ELANE
3hormone activityGO:0051799.1CCK, SCT, PPY

Products for genes affiliated with Exocrine Pancreatic Insufficiency

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Sources for Exocrine Pancreatic Insufficiency

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet