MCID: EXP004
MIFTS: 53

Exophthalmos malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Exophthalmos

Aliases & Descriptions for Exophthalmos:

Name: Exophthalmos 12 42 14 69
Proptosis 12 29 52 14

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:9370
ICD10 33 H05.20
ICD9CM 35 376.30
MeSH 42 D005094
UMLS 69 C0015300

Summaries for Exophthalmos

Disease Ontology : 12 An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit.

MalaCards based summary : Exophthalmos, also known as proptosis, is related to thyrotoxic exophthalmos and pulsating exophthalmos, and has symptoms including exophthalmos, unilateral An important gene associated with Exophthalmos is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Acetylcholine and Timolol have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and bone, and related phenotypes are behavior/neurological and hematopoietic system

Wikipedia : 71 Exophthalmos (also called exophthalmus, exophthalmia, proptosis, or exorbitism) is a bulging of the eye... more...

Related Diseases for Exophthalmos

Diseases in the Exophthalmos family:

Benign Exophthalmos Syndrome

Diseases related to Exophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
id Related Disease Score Top Affiliating Genes
1 thyrotoxic exophthalmos 32.8 CD40LG POMC TG
2 pulsating exophthalmos 12.0
3 endocrine exophthalmos 12.0
4 benign exophthalmos syndrome 11.9
5 constant exophthalmos 11.8
6 crouzon syndrome 11.2
7 enophthalmos 11.1
8 cavernous sinus thrombosis 11.1
9 bohring-opitz syndrome 10.9
10 intermittent proptosis 10.9
11 raine syndrome 10.8
12 prolidase deficiency 10.8
13 camurati-engelmann disease 10.8
14 melnick-needles syndrome 10.8
15 juvenile ossifying fibroma 10.8
16 microcephaly, corpus callosum dysgenesis and cleft lip-palate 10.8
17 acute hemorrhagic encephalitis 10.3 TG TSHR
18 gastrinoma 10.3 TG TSHR
19 neuhauser daly magnelli syndrome 10.3 TG TSHR
20 background diabetic retinopathy 10.3 TG TSHR
21 mesocardia 10.3 TG TSHR
22 krabbe disease 10.3 TG TSHR
23 parachordoma 10.3 TG TSHR
24 atheroembolism of kidney 10.2 CD40LG TG
25 glomangiomyoma 10.2 PRL TG TSHR
26 central neurocytoma 10.2 NF1 PRL
27 thyroiditis 10.2
28 neuronopathy, distal hereditary motor, type viia 10.2 TG TSHR
29 cholesterol embolism 10.2 PRL TG TSHR
30 bestiality 10.2 RHNO1 TSHR
31 aspiration pneumonia 10.2 FLNA RHNO1
32 non-distal monosomy 10q 10.2 TG TGFB1 TSHR
33 conjunctival deposit 10.1 TG TSHR
34 endemic goiter 10.1 TG TSHR
35 ocular motility disease 10.1 CD40LG NF1
36 shwartzman phenomenon 10.1 RHNO1 SCYL1
37 vulvar disease 10.1 RHNO1 SCYL1
38 graves' disease 10.1
39 dyt1 early-onset isolated dystonia 10.1 FGFR2 POMC
40 african histoplasmosis 10.1 POMC PRL
41 articulation disorder 10.1 CD40LG TG TSHR
42 congenital tricuspid stenosis 10.1 POMC PRL
43 intermittent squint 10.1 POMC PRL
44 vertebral artery occlusion 10.1 POMC PRL
45 extragonadal nonseminomatous germ cell tumor 10.1 POMC PRL
46 guillain-barre syndrome 10.1 POMC TG
47 wheat allergy 10.1 POMC PRL
48 pancreatic colloid cystadenoma 10.1 POMC PRL
49 alkhurma hemorrhagic fever 10.1 CD40LG RHNO1
50 testicular lymphoma 10.0 CD40LG PRL TGFB1

Comorbidity relations with Exophthalmos via Phenotypic Disease Network (PDN):


Hypothyroidism

Graphical network of the top 20 diseases related to Exophthalmos:



Diseases related to Exophthalmos

Symptoms & Phenotypes for Exophthalmos

UMLS symptoms related to Exophthalmos:


exophthalmos, unilateral

MGI Mouse Phenotypes related to Exophthalmos:

44 (show all 12)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.16 ASXL1 FGFR2 FLNA NF1 POMC PRL
2 hematopoietic system MP:0005397 10.16 ASXL1 CD40LG FGFR2 FLNA NF1 POMC
3 endocrine/exocrine gland MP:0005379 10.15 TSHR ASXL1 CD40LG FGFR2 NF1 POMC
4 growth/size/body region MP:0005378 10.13 TG TGFB1 TSHR ASXL1 FGFR2 FLNA
5 homeostasis/metabolism MP:0005376 10.13 ASXL1 CD40LG FGFR2 FLNA NF1 POMC
6 immune system MP:0005387 10.1 ASXL1 CD40LG FGFR2 FLNA NF1 POMC
7 nervous system MP:0003631 9.96 FGFR2 FLNA NF1 POMC PRL SCYL1
8 liver/biliary system MP:0005370 9.91 ASXL1 FGFR2 FLNA NF1 POMC PRL
9 neoplasm MP:0002006 9.87 ASXL1 FGFR2 NF1 POMC PRL TGFB1
10 reproductive system MP:0005389 9.7 CD40LG FGFR2 FLNA PRL SCYL1 TGFB1
11 skeleton MP:0005390 9.56 ASXL1 CD40LG FGFR2 FLNA NF1 SCYL1
12 vision/eye MP:0005391 9.17 SCYL1 TGFB1 TSHR ASXL1 FGFR2 FLNA

Drugs & Therapeutics for Exophthalmos

Drugs for Exophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 185)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
2
Timolol Approved Phase 4 26839-75-8 33624 5478
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
4
Propylthiouracil Approved Phase 4,Phase 3,Phase 2 51-52-5 657298
5
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
6
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
7
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
9
Travoprost Approved Phase 4 157283-68-6 5282226
10
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
12
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
13
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
14
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
15
Propranolol Approved, Investigational Phase 4 525-66-6 4946
16
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
17
Ephedrine Approved Phase 4 299-42-3 9294
18
Pseudoephedrine Approved Phase 4 90-82-4 7028
19
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
20
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
21
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
23
Maleic acid Experimental Phase 4 110-16-7 444266
24
Iodine Phase 4,Phase 3,Phase 2 7553-56-2 807
25 triamcinolone acetonide Phase 4
26 cadexomer iodine Phase 4,Phase 3,Phase 2
27 Prednisolone acetate Phase 4,Phase 2,Phase 3
28 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
29 Cholinergic Agents Phase 4,Phase 2,Phase 3
30 Adrenergic Agents Phase 4
31 Adrenergic Antagonists Phase 4
32 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
33 Neuromuscular Agents Phase 4,Phase 2,Phase 3
34 Neuroprotective Agents Phase 4,Phase 2,Phase 3
35 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
36 Adrenergic beta-Antagonists Phase 4
37 Tetrahydrozoline Phase 4,Phase 2
38 Trace Elements Phase 4,Phase 3,Phase 2
39 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
40 Ophthalmic Solutions Phase 4,Phase 2
41 Triamcinolone diacetate Phase 4
42 Triamcinolone hexacetonide Phase 4
43 Hormones Phase 4,Phase 2,Phase 3,Phase 1
44 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
46 Anti-Arrhythmia Agents Phase 4
47 abobotulinumtoxinA Phase 4,Phase 2,Phase 3
48 incobotulinumtoxinA Phase 4,Phase 2,Phase 3
49 onabotulinumtoxinA Phase 4,Phase 2,Phase 3
50 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 105)
id Name Status NCT ID Phase
1 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4
2 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Unknown status NCT01927406 Phase 4
3 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4
4 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4
5 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4
6 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4
7 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4
8 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4
9 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4
10 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4
11 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
12 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4
13 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4
14 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4
15 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4
16 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4
17 Effects of Statins in Graves' Orbitopathy (GO) in Hypercholesterolemic Patients Not yet recruiting NCT03110848 Phase 4
18 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4
19 The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions Unknown status NCT01204359 Phase 3
20 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Unknown status NCT02155049 Phase 3
21 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3
22 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3
23 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3
24 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3
25 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
26 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3
27 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3
28 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3
29 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3
30 Early Levothyroxine Post Radioactive Iodine Active, not recruiting NCT01950260 Phase 2, Phase 3
31 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Not yet recruiting NCT03131726 Phase 3
32 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3
33 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3
34 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2
35 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
36 Pilot Study to Determine Safety and Efficacy of Orbital Injections of LIPO-102 in Patients With Symptomatic Exophthalmos Associated With Thyroid-related Eye Disease (TED) Completed NCT00954057 Phase 2
37 Rituximab Treatment of Graves' Dysthyroid Ophthalmopathy Completed NCT00424151 Phase 1, Phase 2
38 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy Completed NCT01727973 Phase 1, Phase 2
39 Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients Completed NCT02993302 Phase 2
40 A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease Completed NCT02713256 Phase 2
41 Radioactive Iodide Therapy for Pediatric Graves' Disease Completed NCT01269749 Phase 2
42 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2
43 Rituximab in the Treatment of Graves' Disease Completed NCT00150111 Phase 1, Phase 2
44 Celecoxib for Thyroid Eye Disease Recruiting NCT02845336 Phase 2
45 B-cell Depletion Therapy With Rituximab for Thyroid Eye Disease Recruiting NCT02316691 Phase 2
46 Teprotumumab Treatment in Patients With Active Thyroid Eye Disease Active, not recruiting NCT01868997 Phase 2
47 Lanreotide (Somatuline Autogel) in Thyroid-associated Ophthalmopathy Treatment Terminated NCT00288522 Phase 2
48 A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease Terminated NCT01114503 Phase 2
49 Use of Azithromycin as Immunomodulatory Therapy in Grave&Apos;s Orbitopathy Withdrawn NCT01379196 Phase 1, Phase 2
50 Function of Regulatory T Cells Improved by Dexamethasone in Graves' Patients Completed NCT01534169 Phase 1

Search NIH Clinical Center for Exophthalmos

Cochrane evidence based reviews: exophthalmos

Genetic Tests for Exophthalmos

Genetic tests related to Exophthalmos:

id Genetic test Affiliating Genes
1 Proptosis 29

Anatomical Context for Exophthalmos

MalaCards organs/tissues related to Exophthalmos:

39
Eye, Thyroid, Bone, Pituitary, Lung, Prostate, B Cells

Publications for Exophthalmos

Articles related to Exophthalmos:

(show top 50) (show all 596)
id Title Authors Year
1
Exophthalmos (Graves' orbitopathy) in an ancient sculpture. ( 27098805 )
2016
2
A rare cause of exophthalmos in children. ( 26895765 )
2016
3
The First Reported Case of Erdheim-Chester Disease in Egypt with Bilateral Exophthalmos, Loss of Vision, and Multi-Organ Involvement in a Young Woman. ( 27237445 )
2016
4
Sphenoid Wing Dysplasia with Pulsatile Exophthalmos in Neurofibromatosis Type 1. ( 27280756 )
2016
5
Treatment of exophthalmos and strabismus surgery in thyroid-associated orbitopathy. ( 26775634 )
2016
6
Acute Myeloid Leukemia with Initial Presentation of Facial Palsy and Exophthalmos. ( 27411795 )
2016
7
Erdheim-Chester Disease Presenting With Intractable Exophthalmos and Bone Lesions. ( 27865309 )
2016
8
Exophthalmos Revealing a Krukenberg Tumor: A Case Presentation and Review of the Literature. ( 27721760 )
2016
9
Mild Camuratia89Engelamann disease presenting with exophthalmos as the first and only manifestation: A case report. ( 27484238 )
2016
10
Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos. ( 26895762 )
2016
11
Exophthalmos, Diplopia, and Bilateral Eyelid Edema: Symptoms of Ocular Mastocytosis. ( 27560850 )
2016
12
Radiation therapy as part of the therapeutic regimen for extensive multilocular myxedema in a patient with exophthalmos, myxedema and osteoarthropathy syndrome: A case report. ( 26137080 )
2015
13
Partial thickness autologus calvarial bone orbitocranioplasty for a sphenorbital encephalocele presenting as pulsatile exophthalmos. ( 25972944 )
2015
14
Intraorbital Encephalocele Presenting with Exophthalmos and Orbital Dystopia : CT and MRI Findings. ( 25674346 )
2015
15
Cholesterol granuloma of a Haller cell associated with unilateral exophthalmos and diplopia. ( 26719083 )
2015
16
Ethmoid pneumocele presenting with exophthalmos 15 years after endoscopic sinus surgery. ( 26302735 )
2015
17
The philosopher Socrates had exophthalmos (a term coined by Plato) and probably Graves' disease. ( 25553768 )
2015
18
Slowly progressive Lemierre's syndrome with orbital pain and exophthalmos. ( 26419364 )
2015
19
Relation of the Vector Force Needed to Lift the Upper Eyelids and the Degree of Exophthalmos. ( 26086928 )
2015
20
Dynamic exophthalmos and lateral strabismus in a dog caused by masticatory muscle myositis. ( 25728848 )
2015
21
A Hypothesis for the Pathologic Mechanism of Idiopathic Exophthalmos Based on Computed Tomographic Evaluations. ( 26114529 )
2015
22
Posttraumatic pulsating exophthalmos in a child. ( 24119872 )
2014
23
Dural arteriovenous fistula presenting with exophthalmos and seizures. ( 24439472 )
2014
24
Orbital reconstruction for pulsatile exophthalmos secondary to sphenoid wing dysplasia. ( 24835868 )
2014
25
Pulsatile exophthalmos: effect of orthostatic pressure difference. ( 24407832 )
2014
26
Exophthalmos Myxedema Acropachy Syndrome: A Case Report. ( 26060688 )
2014
27
A mysterious post-traumatic pulsatile exophthalmos. ( 24022797 )
2014
28
Fronto-orbital osteoma. Answer to the e-quid "Unilateral exophthalmos in a 30-year-old man". ( 23294927 )
2013
29
A new approach to aesthetic maxillofacial surgery: surgical treatment of unilateral exophthalmos due to maxillary sinus mucocele. ( 23714910 )
2013
30
Exophthalmos as a first manifestation of the systemic spread of small cell lung cancer. ( 24059030 )
2013
31
Exophthalmos due to odontogenic intraorbital abscess in Cebus apella. ( 23311626 )
2013
32
Palpebral ptosis, fixed mydriasis and exophthalmos: an uncommon presentation of new diabetes mellitus. ( 22907808 )
2013
33
Case of recurrent exophthalmos: angioedema versus idiopathic orbital pseudotumor. ( 24565625 )
2013
34
Arachnoid Cyst in the Middle Cranial Fossa Presenting with Pulsatile Exophthalmos: Case Report and Literature Review. ( 24305013 )
2013
35
CT features of exophthalmos in Chinese subjects with thyroid-associated ophthalmopathy. ( 23638413 )
2013
36
Loss of visual acuity on the left eye and ipsilateral exophthalmos in a 68-year-old male patient. ( 24313789 )
2013
37
Intradiploic hematoma of the frontal bone with secondary exophthalmos in a mare. ( 23953510 )
2013
38
Exophthalmos: A Forgotten Clinical Sign of Cushing's Syndrome. ( 23555062 )
2013
39
Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel. ( 22192474 )
2012
40
Unilateral exophthalmos and multiple subcutaneous nodules as a result of extranodal marginal zone lymphoma. ( 22203764 )
2012
41
Intraorbital epidermoid cyst: a 5-year-old with exophthalmos and strabismus. ( 22446470 )
2012
42
The current role of radiotherapy in "Bilateral exophthalmos in Grave's Disease". ( 23935304 )
2012
43
Paralytic exophthalmos in chronic progressive external ophthalmoplegia. ( 22504268 )
2012
44
Unilateral exophthalmos revealing metastatic prostate cancer. ( 22245296 )
2012
45
Congenital orbital encephalocele, orbital dystopia, and exophthalmos. ( 22801176 )
2012
46
Index of suspicion: Case 1: Abdominal trauma, pain, and tenderness associated with anemia and hematuria in a 14-year-old boy. Case 2: Ptosis, diplopia, tremors, and mild exophthalmos in a 9-year-old girl. Case 3: Persistent cough, shortness of breath, and localized decreased aeration in an 18-year-old girl. ( 22045898 )
2011
47
Exophthalmos due to multicentric B-cell lymphoma in a goat. ( 22654143 )
2011
48
Visual vignette. Steroid-induced exophthalmos. ( 20713333 )
2011
49
Reconstruction of the sphenoid wing in a case of neurofibromatosis type 1 and complex unilateral orbital dysplasia with pulsating exophthalmos. ( 21471549 )
2011
50
Acute severe exophthalmos in an infant with orbital capillary hemangioma. ( 21331696 )
2011

Variations for Exophthalmos

Expression for Exophthalmos

Search GEO for disease gene expression data for Exophthalmos.

Pathways for Exophthalmos

GO Terms for Exophthalmos

Cellular components related to Exophthalmos according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CD40LG FGFR2 FLNA POMC PRL TG
2 secretory granule GO:0030141 8.8 POMC PRL TGFB1

Biological processes related to Exophthalmos according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 FGFR2 PRL TGFB1 TSHR
2 cellular response to ionizing radiation GO:0071479 9.43 RHNO1 TGFB1
3 regulation of multicellular organism growth GO:0040014 9.37 FGFR2 PRL
4 wound healing GO:0042060 9.33 FGFR2 NF1 TGFB1
5 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.32 FGFR2 TGFB1
6 positive regulation of adenylate cyclase activity GO:0045762 9.26 NF1 TSHR
7 positive regulation of epithelial cell proliferation GO:0050679 9.13 FGFR2 PRL TGFB1
8 negative regulation of neuroblast proliferation GO:0007406 8.62 NF1 TGFB1

Molecular functions related to Exophthalmos according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 POMC PRL TG

Sources for Exophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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