Aliases & Classifications for Exophthalmos

MalaCards integrated aliases for Exophthalmos:

Name: Exophthalmos 12 42 14 69
Proptosis 12 29 52

Classifications:



External Ids:

Disease Ontology 12 DOID:9370
ICD10 33 H05.20
ICD9CM 35 376.30
MeSH 42 D005094
UMLS 69 C0015300

Summaries for Exophthalmos

Disease Ontology : 12 An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit.

MalaCards based summary : Exophthalmos, also known as proptosis, is related to pleomorphic adenoma and endocrine exophthalmos, and has symptoms including exophthalmos, unilateral An important gene associated with Exophthalmos is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways/superpathways are MAPK signaling pathway and Syndecan-2-mediated signaling events. The drugs Propylthiouracil and Bimatoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and bone, and related phenotypes are hematopoietic system and behavior/neurological

Wikipedia : 72 Exophthalmos (also called exophthalmus, exophthalmia, proptosis, or exorbitism) is a bulging of the eye... more...

Related Diseases for Exophthalmos

Diseases related to Exophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
id Related Disease Score Top Affiliating Genes
1 pleomorphic adenoma 29.4 CD34 TG
2 endocrine exophthalmos 12.0
3 pulsating exophthalmos 12.0
4 thyrotoxic exophthalmos 11.9
5 constant exophthalmos 11.7
6 crouzon syndrome 11.2
7 enophthalmos 11.0
8 cavernous sinus thrombosis 11.0
9 bohring-opitz syndrome 10.9
10 luxation of globe 10.9
11 raine syndrome 10.8
12 intermittent proptosis 10.8
13 microcephaly, corpus callosum dysgenesis and cleft lip-palate 10.8
14 prolidase deficiency 10.7
15 camurati-engelmann disease 10.7
16 melnick-needles syndrome 10.7
17 craniofacial dysostosis with diaphyseal hyperplasia 10.7
18 juvenile ossifying fibroma 10.7
19 petit-fryns syndrome 10.7
20 rozin hertz goodman syndrome 10.7
21 chronic polyneuropathy 10.6 TG TSHR
22 kidney disease 10.6 TG TSHR
23 nephrogenic systemic fibrosis 10.6 TG TSHR
24 panhypophysitis 10.6 TG TSHR
25 parachordoma 10.6 TG TSHR
26 background diabetic retinopathy 10.6 TG TSHR
27 pontiac fever 10.6 FLNA RHNO1
28 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 10.6 TG TSHR
29 amelogenesis imperfecta, hypomaturation type, iia6 10.5 TG TSHR
30 esotropia 10.5 FGFR2 TG
31 cerebral lipidosis 10.5 TG TSHR
32 conjunctival deposit 10.5 TG TSHR
33 mechanical strabismus 10.5 RHNO1 TSHR
34 endemic goiter 10.5 TG TSHR
35 lung occult large cell carcinoma 10.5 TG TSHR
36 nephrolithiasis 10.5 ASXL1 NF1
37 hypothyroidism, congenital, nongoitrous 4 10.5 PRL TG
38 c5 deficiency 10.5 FGFR2 TG
39 central neurocytoma 10.4 NF1 PRL
40 lung lymphoma 10.4 NF1 TG
41 posterior cerebral artery infarction 10.3 RHNO1 SCYL1
42 non-distal trisomy 10q 10.3 TG TGFB1 TSHR
43 diphtheria 10.3 NF1 TG
44 epidural abscess 10.3 NF1 TG
45 fibrolamellar carcinoma 10.3 PRL TG TSHR
46 skin meningioma 10.2 PRL TG TSHR
47 fallopian tube leiomyoma 10.2 PRL TG
48 nodular prostate 10.2 TG TSHR
49 cholesterol embolism 10.2 PRL TG TSHR
50 thyroiditis 10.2

Comorbidity relations with Exophthalmos via Phenotypic Disease Network (PDN):


Hypothyroidism

Graphical network of the top 20 diseases related to Exophthalmos:



Diseases related to Exophthalmos

Symptoms & Phenotypes for Exophthalmos

UMLS symptoms related to Exophthalmos:


exophthalmos, unilateral

MGI Mouse Phenotypes related to Exophthalmos:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.09 TGFB1 TSHR ASXL1 CD34 FGFR2 FLNA
2 behavior/neurological MP:0005386 10.08 ASXL1 FGFR2 FLNA NF1 PRL SCYL1
3 homeostasis/metabolism MP:0005376 10.06 ASXL1 CD34 FGFR2 FLNA NF1 PRL
4 immune system MP:0005387 10.02 ASXL1 CD34 FGFR2 FLNA NF1 PRL
5 endocrine/exocrine gland MP:0005379 10 ASXL1 FGFR2 NF1 PRL TG TGFB1
6 liver/biliary system MP:0005370 9.8 ASXL1 FGFR2 FLNA NF1 PRL TGFB1
7 neoplasm MP:0002006 9.8 ASXL1 CD34 FGFR2 NF1 PRL TGFB1
8 nervous system MP:0003631 9.76 TG TGFB1 TSHR FGFR2 FLNA NF1
9 skeleton MP:0005390 9.5 TGFB1 TSHR ASXL1 FGFR2 FLNA NF1
10 vision/eye MP:0005391 9.17 ASXL1 FGFR2 FLNA NF1 SCYL1 TGFB1

Drugs & Therapeutics for Exophthalmos

Drugs for Exophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 185)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propylthiouracil Approved Phase 4,Phase 3,Phase 2 51-52-5 657298
2
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
3
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
4
Timolol Approved Phase 4 26839-75-8 33624 5478
5
Travoprost Approved Phase 4 157283-68-6 5282226
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
7
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
8
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
9
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
10
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
11
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
12
Ephedrine Approved Phase 4 299-42-3 9294
13
Pseudoephedrine Approved Phase 4 90-82-4 7028
14
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
15
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
16
Propranolol Approved, Investigational Phase 4 525-66-6 4946
17
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
18
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
19
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
20
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
22
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
23
Maleic acid Experimental Phase 4 110-16-7 444266
24
Iodine Investigational Phase 4,Phase 3,Phase 2 7553-56-2 807
25
Dinoprost Investigational Phase 4 551-11-1 5283078
26 Antimetabolites Phase 4,Phase 3
27 Antithyroid Agents Phase 4,Phase 3,Phase 1,Phase 2
28 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
29 Hormones Phase 4,Phase 2,Phase 3,Phase 1
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
31 Adrenergic Agents Phase 4
32 Adrenergic Antagonists Phase 4
33 Adrenergic beta-Antagonists Phase 4
34 Anti-Arrhythmia Agents Phase 4
35 Antihypertensive Agents Phase 4,Phase 3
36 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
37 Ophthalmic Solutions Phase 4,Phase 2
38 Tetrahydrozoline Phase 4,Phase 2
39 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
40 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
41 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
42 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1
43 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
44 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
45 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
46 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
47 Neuroprotective Agents Phase 4,Phase 2,Phase 3
48 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
49 Prednisolone acetate Phase 4,Phase 2,Phase 3
50 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 112)

id Name Status NCT ID Phase Drugs
1 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
2 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Unknown status NCT01927406 Phase 4 Prostaglandin Analog;Timolol
3 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
4 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
5 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
6 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
7 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
8 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
9 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
10 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
11 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
12 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
13 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
14 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
15 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
16 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
17 Effects of Statins in Graves' Orbitopathy (GO) in Hypercholesterolemic Patients Not yet recruiting NCT03110848 Phase 4 Atorvastatin;Methylprednisolone
18 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4 Botulinum Toxin Type A;Saline injection
19 The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions Unknown status NCT01204359 Phase 3
20 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Unknown status NCT02155049 Phase 3 bimatoprost 0.03%
21 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
22 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone
23 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3 Rituximab;Saline;Methylprednisolone
24 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
25 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
26 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
27 Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study Recruiting NCT03298867 Phase 3
28 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
29 Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
30 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3 Antithyroid Drug
31 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
32 Early Levothyroxine Post Radioactive Iodine Active, not recruiting NCT01950260 Phase 2, Phase 3 Levothyroxine
33 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Not yet recruiting NCT03131726 Phase 3 Simvastatin 40mg;Diclofenac Potassium 50 MG
34 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3 Methylprednisolone + ASTED;Methylprednisolone +Placebo
35 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3 ASTED
36 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
37 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
38 Pilot Study to Determine Safety and Efficacy of Orbital Injections of LIPO-102 in Patients With Symptomatic Exophthalmos Associated With Thyroid-related Eye Disease (TED) Completed NCT00954057 Phase 2 LIPO-102;Placebo
39 Rituximab Treatment of Graves' Dysthyroid Ophthalmopathy Completed NCT00424151 Phase 1, Phase 2 Rituximab
40 Teprotumumab Treatment in Patients With Active Thyroid Eye Disease Completed NCT01868997 Phase 2 teprotumumab;normal saline
41 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy Completed NCT01727973 Phase 1, Phase 2 Doxycycline
42 Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients Completed NCT02993302 Phase 2 1α-D3;Placebos
43 A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease Completed NCT02713256 Phase 2 CFZ533
44 Radioactive Iodide Therapy for Pediatric Graves' Disease Completed NCT01269749 Phase 2 ATD Group
45 Rituximab in the Treatment of Graves' Disease Completed NCT00150111 Phase 1, Phase 2 Methimazole;Rituximab
46 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
47 Celecoxib for Thyroid Eye Disease Recruiting NCT02845336 Phase 2 Celecoxib;artificial tears
48 Lanreotide (Somatuline Autogel) in Thyroid-associated Ophthalmopathy Treatment Terminated NCT00288522 Phase 2 Lanreotide (Autogel formulation). Duration of treatment - 3 injections, 1 every 28 days
49 A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease Terminated NCT01114503 Phase 2 Otelixizumab - low dose;Otelixizumab - medium low dose;Otelixizumab - medium high dose;Otelixizumab - high dose;Otelixizumab;Methylprednisolone
50 Use of Azithromycin as Immunomodulatory Therapy in Grave&Apos;s Orbitopathy Withdrawn NCT01379196 Phase 1, Phase 2 Azithromycin

Search NIH Clinical Center for Exophthalmos

Cochrane evidence based reviews: exophthalmos

Genetic Tests for Exophthalmos

Genetic tests related to Exophthalmos:

id Genetic test Affiliating Genes
1 Proptosis 29

Anatomical Context for Exophthalmos

MalaCards organs/tissues related to Exophthalmos:

39
Eye, Thyroid, Bone, B Cells, Pituitary, T Cells, Lung

Publications for Exophthalmos

Articles related to Exophthalmos:

(show top 50) (show all 601)
id Title Authors Year
1
Exophthalmos due to sterile neutrophilic dermatosis in a dog. ( 28294507 )
2017
2
Interdisciplinary Management of Minimally Displaced Orbital Roof Fractures: Delayed Pulsatile Exophthalmos and Orbital Encephalocele. ( 28210402 )
2017
3
Exophthalmos associated to orbital zygomatic mucocele and complex maxillary malformation in a puppy. ( 28884074 )
2017
4
Spontaneous Unilateral Subperiosteal Hematoma in the Orbit due to Self-Induced Asphyxia: Unusual Cause of Unilateral Exophthalmos. ( 28512426 )
2017
5
Exophthalmos and hyperparathyroidism. ( 28750881 )
2017
6
Exophthalmos Revealing a Krukenberg Tumor: A Case Presentation and Review of the Literature. ( 27721760 )
2016
7
Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos. ( 26895762 )
2016
8
Sphenoid Wing Dysplasia with Pulsatile Exophthalmos in Neurofibromatosis Type 1. ( 27280756 )
2016
9
Treatment of exophthalmos and strabismus surgery in thyroid-associated orbitopathy. ( 26775634 )
2016
10
Acute Myeloid Leukemia with Initial Presentation of Facial Palsy and Exophthalmos. ( 27411795 )
2016
11
Erdheim-Chester Disease Presenting With Intractable Exophthalmos and Bone Lesions. ( 27865309 )
2016
12
Exophthalmos, Diplopia, and Bilateral Eyelid Edema: Symptoms of Ocular Mastocytosis. ( 27560850 )
2016
13
A rare cause of exophthalmos in children. ( 26895765 )
2016
14
Exophthalmos (Graves' orbitopathy) in an ancient sculpture. ( 27098805 )
2016
15
Mild Camuratia89Engelamann disease presenting with exophthalmos as the first and only manifestation: A case report. ( 27484238 )
2016
16
The First Reported Case of Erdheim-Chester Disease in Egypt with Bilateral Exophthalmos, Loss of Vision, and Multi-Organ Involvement in a Young Woman. ( 27237445 )
2016
17
Intraorbital Encephalocele Presenting with Exophthalmos and Orbital Dystopia : CT and MRI Findings. ( 25674346 )
2015
18
The philosopher Socrates had exophthalmos (a term coined by Plato) and probably Graves' disease. ( 25553768 )
2015
19
Relation of the Vector Force Needed to Lift the Upper Eyelids and the Degree of Exophthalmos. ( 26086928 )
2015
20
Ethmoid pneumocele presenting with exophthalmos 15 years after endoscopic sinus surgery. ( 26302735 )
2015
21
Dynamic exophthalmos and lateral strabismus in a dog caused by masticatory muscle myositis. ( 25728848 )
2015
22
Radiation therapy as part of the therapeutic regimen for extensive multilocular myxedema in a patient with exophthalmos, myxedema and osteoarthropathy syndrome: A case report. ( 26137080 )
2015
23
Slowly progressive Lemierre's syndrome with orbital pain and exophthalmos. ( 26419364 )
2015
24
Partial thickness autologus calvarial bone orbitocranioplasty for a sphenorbital encephalocele presenting as pulsatile exophthalmos. ( 25972944 )
2015
25
A Hypothesis for the Pathologic Mechanism of Idiopathic Exophthalmos Based on Computed Tomographic Evaluations. ( 26114529 )
2015
26
Cholesterol granuloma of a Haller cell associated with unilateral exophthalmos and diplopia. ( 26719083 )
2015
27
Posttraumatic pulsating exophthalmos in a child. ( 24119872 )
2014
28
A mysterious post-traumatic pulsatile exophthalmos. ( 24022797 )
2014
29
Dural arteriovenous fistula presenting with exophthalmos and seizures. ( 24439472 )
2014
30
Exophthalmos Myxedema Acropachy Syndrome: A Case Report. ( 26060688 )
2014
31
Pulsatile exophthalmos: effect of orthostatic pressure difference. ( 24407832 )
2014
32
Orbital reconstruction for pulsatile exophthalmos secondary to sphenoid wing dysplasia. ( 24835868 )
2014
33
Arachnoid Cyst in the Middle Cranial Fossa Presenting with Pulsatile Exophthalmos: Case Report and Literature Review. ( 24305013 )
2013
34
Loss of visual acuity on the left eye and ipsilateral exophthalmos in a 68-year-old male patient. ( 24313789 )
2013
35
Exophthalmos due to odontogenic intraorbital abscess in Cebus apella. ( 23311626 )
2013
36
A new approach to aesthetic maxillofacial surgery: surgical treatment of unilateral exophthalmos due to maxillary sinus mucocele. ( 23714910 )
2013
37
Palpebral ptosis, fixed mydriasis and exophthalmos: an uncommon presentation of new diabetes mellitus. ( 22907808 )
2013
38
Case of recurrent exophthalmos: angioedema versus idiopathic orbital pseudotumor. ( 24565625 )
2013
39
Exophthalmos as a first manifestation of the systemic spread of small cell lung cancer. ( 24059030 )
2013
40
CT features of exophthalmos in Chinese subjects with thyroid-associated ophthalmopathy. ( 23638413 )
2013
41
Exophthalmos: A Forgotten Clinical Sign of Cushing's Syndrome. ( 23555062 )
2013
42
Intradiploic hematoma of the frontal bone with secondary exophthalmos in a mare. ( 23953510 )
2013
43
Fronto-orbital osteoma. Answer to the e-quid "Unilateral exophthalmos in a 30-year-old man". ( 23294927 )
2013
44
Congenital orbital encephalocele, orbital dystopia, and exophthalmos. ( 22801176 )
2012
45
Paralytic exophthalmos in chronic progressive external ophthalmoplegia. ( 22504268 )
2012
46
Unilateral exophthalmos revealing metastatic prostate cancer. ( 22245296 )
2012
47
Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel. ( 22192474 )
2012
48
Intraorbital epidermoid cyst: a 5-year-old with exophthalmos and strabismus. ( 22446470 )
2012
49
The current role of radiotherapy in "Bilateral exophthalmos in Grave's Disease". ( 23935304 )
2012
50
Unilateral exophthalmos and multiple subcutaneous nodules as a result of extranodal marginal zone lymphoma. ( 22203764 )
2012

Variations for Exophthalmos

Expression for Exophthalmos

Search GEO for disease gene expression data for Exophthalmos.

Pathways for Exophthalmos

Pathways related to Exophthalmos according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.89 FGFR2 FLNA NF1 TGFB1
2 10.67 NF1 TGFB1
3 9.4 TG TSHR

GO Terms for Exophthalmos

Biological processes related to Exophthalmos according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 digestive tract development GO:0048565 9.43 FGFR2 TGFB1
2 cellular response to ionizing radiation GO:0071479 9.4 RHNO1 TGFB1
3 regulation of multicellular organism growth GO:0040014 9.37 FGFR2 PRL
4 wound healing GO:0042060 9.33 FGFR2 NF1 TGFB1
5 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.32 FGFR2 TGFB1
6 positive regulation of adenylate cyclase activity GO:0045762 9.26 NF1 TSHR
7 negative regulation of neuroblast proliferation GO:0007406 8.96 NF1 TGFB1
8 positive regulation of odontogenesis GO:0042482 8.62 CD34 TGFB1

Sources for Exophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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