Aliases & Classifications for Exophthalmos

MalaCards integrated aliases for Exophthalmos:

Name: Exophthalmos 12 72 41 14 69
Proptosis 12 28 51

Classifications:



External Ids:

Disease Ontology 12 DOID:9370
ICD10 32 H05.20
ICD9CM 34 376.30
MeSH 41 D005094
UMLS 69 C0015300

Summaries for Exophthalmos

Disease Ontology : 12 An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit.

MalaCards based summary : Exophthalmos, also known as proptosis, is related to myxedema and graves disease 1, and has symptoms including exophthalmos, unilateral An important gene associated with Exophthalmos is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways/superpathways are MAPK signaling pathway and Syndecan-2-mediated signaling events. The drugs Acetylcholine and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, thyroid and bone, and related phenotypes are hematopoietic system and behavior/neurological

Wikipedia : 72 Exophthalmos (also called exophthalmus, exophthalmia, proptosis, or exorbitism) is a bulging of the eye... more...

Related Diseases for Exophthalmos

Diseases related to Exophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 myxedema 30.6 TG TSHR
2 graves disease 1 30.5 TG TSHR
3 hyperthyroidism 30.1 PRL TG TSHR
4 hypothyroidism 29.9 PRL TG TSHR
5 orbital disease 29.8 RHNO1 TSHR
6 pulsating exophthalmos 12.1
7 endocrine exophthalmos 12.1
8 thyrotoxic exophthalmos 12.1
9 constant exophthalmos 11.9
10 intermittent proptosis 11.4
11 crouzon syndrome 11.3
12 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 11.2
13 enophthalmos 11.2
14 cavernous sinus thrombosis 11.2
15 bohring-opitz syndrome 11.0
16 raine syndrome 10.9
17 craniofacial dysostosis with diaphyseal hyperplasia 10.8
18 camurati-engelmann disease 10.8
19 prolidase deficiency 10.8
20 melnick-needles syndrome 10.8
21 juvenile ossifying fibroma 10.8
22 petit-fryns syndrome 10.8
23 rozin hertz goodman syndrome 10.8
24 benign struma ovarii 10.4 TG TSHR
25 neonatal hypothyroidism 10.4 TG TSHR
26 athyreosis 10.4 TG TSHR
27 struma ovarii 10.4 TG TSHR
28 endemic goiter 10.4 TG TSHR
29 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.4 FGFR2 TG
30 otomycosis 10.4 FLNA RHNO1
31 hypothyroidism, congenital, nongoitrous, 2 10.4 TG TSHR
32 nontoxic goiter 10.3 TG TSHR
33 subacute thyroiditis 10.3 TG TSHR
34 hypertropia 10.3 FGFR2 TG
35 toxic diffuse goiter 10.3 TG TSHR
36 myelodysplastic myeloproliferative cancer 10.3 ASXL1 NF1
37 hypothyroidism, congenital, nongoitrous, 4 10.3 PRL TG
38 papillary thyroid microcarcinoma 10.3 TG TSHR
39 thyroiditis 10.3
40 obstructive hydrocephalus 10.2 NF1 PRL
41 paraphimosis 10.2 CD34 FLNA
42 amyloid tumor 10.2 NF1 TG
43 spinal canal and spinal cord meningioma 10.2 NF1 TG
44 graves' disease 10.2
45 ovarian cystic teratoma 10.2 PRL TG
46 cranial nerve palsy 10.2 RHNO1 SCYL1
47 thyroid angiosarcoma 10.2 CD34 TG
48 differentiated thyroid carcinoma 10.2 TG TGFB1 TSHR
49 thyroid sarcoma 10.2 CD34 TG
50 spinal meningioma 10.2 NF1 TG

Comorbidity relations with Exophthalmos via Phenotypic Disease Network (PDN):


Hypothyroidism

Graphical network of the top 20 diseases related to Exophthalmos:



Diseases related to Exophthalmos

Symptoms & Phenotypes for Exophthalmos

UMLS symptoms related to Exophthalmos:


exophthalmos, unilateral

MGI Mouse Phenotypes related to Exophthalmos:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.09 TGFB1 TSHR TG ASXL1 NF1 CD34
2 behavior/neurological MP:0005386 10.08 TGFB1 TSHR FLNA ASXL1 NF1 PRL
3 homeostasis/metabolism MP:0005376 10.06 TGFB1 TSHR TG FLNA ASXL1 NF1
4 immune system MP:0005387 10.02 TGFB1 TSHR ASXL1 NF1 CD34 PRL
5 endocrine/exocrine gland MP:0005379 10 TGFB1 TSHR TG ASXL1 NF1 PRL
6 liver/biliary system MP:0005370 9.8 TGFB1 FLNA ASXL1 NF1 PRL FGFR2
7 neoplasm MP:0002006 9.8 TSHR TGFB1 ASXL1 NF1 CD34 PRL
8 nervous system MP:0003631 9.76 TGFB1 TSHR TG FLNA NF1 PRL
9 skeleton MP:0005390 9.5 TGFB1 TSHR FLNA ASXL1 NF1 FGFR2
10 vision/eye MP:0005391 9.17 TGFB1 TSHR ASXL1 NF1 FGFR2 SCYL1

Drugs & Therapeutics for Exophthalmos

Drugs for Exophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 187)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
2
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
3
Iodine Approved, Investigational Phase 4,Phase 3,Phase 2 7553-56-2 807
4
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2 51-52-5 657298
5
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
7
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
9
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
10
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
11
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
12
Propranolol Approved, Investigational Phase 4,Phase 3 525-66-6 4946
13
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
14
Ephedrine Approved Phase 4 299-42-3 9294
15
Pseudoephedrine Approved Phase 4 90-82-4 7028
16
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
17
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
18
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
19
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
21
Dinoprost Investigational Phase 4 551-11-1 5283078
22 triamcinolone acetonide Phase 4
23 cadexomer iodine Phase 4,Phase 3,Phase 2
24 Prednisolone acetate Phase 4,Phase 2,Phase 3
25 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
26 abobotulinumtoxinA Phase 4,Phase 2,Phase 3
27 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
28 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
29 Micronutrients Phase 4,Phase 3,Phase 2
30 Cholinergic Agents Phase 4,Phase 2,Phase 3
31 Neuromuscular Agents Phase 4,Phase 2,Phase 3
32 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
33 Neuroprotective Agents Phase 4,Phase 2,Phase 3
34 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
35 Trace Elements Phase 4,Phase 3,Phase 2
36 Triamcinolone diacetate Phase 4
37 Triamcinolone hexacetonide Phase 4
38 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
39 onabotulinumtoxinA Phase 4,Phase 2,Phase 3
40 Hormones Phase 4,Phase 2,Phase 3,Phase 1
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
42 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
43 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
44 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3
46 Immunosuppressive Agents Phase 4
47 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2
48 Prednisolone phosphate Phase 4,Phase 2,Phase 3
49 Antimetabolites Phase 4,Phase 3
50 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 112)

# Name Status NCT ID Phase Drugs
1 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
2 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
3 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
4 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
5 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
6 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
7 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
8 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
9 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
10 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
11 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
12 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
13 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
14 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
15 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
16 Effects of Statins in Graves' Orbitopathy (GO) in Hypercholesterolemic Patients Not yet recruiting NCT03110848 Phase 4 Atorvastatin;Methylprednisolone
17 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Withdrawn NCT01927406 Phase 4 Prostaglandin Analog;Timolol
18 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4 Botulinum Toxin Type A;Saline injection
19 The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions Unknown status NCT01204359 Phase 3
20 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone
21 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
22 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Completed NCT02155049 Phase 3 bimatoprost 0.03%
23 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3 Rituximab;Saline;Methylprednisolone
24 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
25 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
26 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
27 Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study Recruiting NCT03298867 Phase 3
28 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
29 Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
30 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3 Antithyroid Drug
31 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Recruiting NCT03131726 Phase 3 Simvastatin 40mg;Diclofenac Potassium 50 MG
32 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
33 Early Levothyroxine Post Radioactive Iodine Active, not recruiting NCT01950260 Phase 2, Phase 3 Levothyroxine
34 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3 Methylprednisolone + ASTED;Methylprednisolone +Placebo
35 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3 ASTED
36 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
37 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
38 Pilot Study to Determine Safety and Efficacy of Orbital Injections of LIPO-102 in Patients With Symptomatic Exophthalmos Associated With Thyroid-related Eye Disease (TED) Completed NCT00954057 Phase 2 LIPO-102;Placebo
39 Rituximab Treatment of Graves' Dysthyroid Ophthalmopathy Completed NCT00424151 Phase 1, Phase 2 Rituximab
40 Teprotumumab Treatment in Patients With Active Thyroid Eye Disease Completed NCT01868997 Phase 2 teprotumumab;normal saline
41 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy Completed NCT01727973 Phase 1, Phase 2 Doxycycline
42 Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients Completed NCT02993302 Phase 2 1α-D3;Placebos
43 A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease Completed NCT02713256 Phase 2 CFZ533
44 Radioactive Iodide Therapy for Pediatric Graves' Disease Completed NCT01269749 Phase 2 ATD Group
45 Rituximab in the Treatment of Graves' Disease Completed NCT00150111 Phase 1, Phase 2 Methimazole;Rituximab
46 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
47 Celecoxib for Thyroid Eye Disease Recruiting NCT02845336 Phase 2 Celecoxib;artificial tears
48 Lanreotide (Somatuline Autogel) in Thyroid-associated Ophthalmopathy Treatment Terminated NCT00288522 Phase 2 Lanreotide (Autogel formulation). Duration of treatment - 3 injections, 1 every 28 days
49 A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease Terminated NCT01114503 Phase 2 Otelixizumab - low dose;Otelixizumab - medium low dose;Otelixizumab - medium high dose;Otelixizumab - high dose;Otelixizumab;Methylprednisolone
50 Use of Azithromycin as Immunomodulatory Therapy in Grave&Apos;s Orbitopathy Withdrawn NCT01379196 Phase 1, Phase 2 Azithromycin

Search NIH Clinical Center for Exophthalmos

Cochrane evidence based reviews: exophthalmos

Genetic Tests for Exophthalmos

Genetic tests related to Exophthalmos:

# Genetic test Affiliating Genes
1 Proptosis 28

Anatomical Context for Exophthalmos

MalaCards organs/tissues related to Exophthalmos:

38
Eye, Thyroid, Bone, B Cells, Pituitary, T Cells, Lung

Publications for Exophthalmos

Articles related to Exophthalmos:

(show top 50) (show all 608)
# Title Authors Year
1
Computed Tomography Measurements as a Standard of Exophthalmos? Two-Dimensional Versus Three-Dimensional Techniques. ( 29377729 )
2018
2
Extensive ARMC5 genetic variance in primary bilateral macronodular adrenal hyperplasia that started with exophthalmos: a case report. ( 29343284 )
2018
3
Exophthalmos in a young woman with no graves' disease - a case report of IgG4-related orbitopathy. ( 29329570 )
2018
4
Utility of rituximab treatment for exophthalmos, myxedema, and osteoarthropathy syndrome resistant to corticosteroids due to Graves' disease: a case report. ( 29448964 )
2018
5
Unilateral Exophthalmos due to Lymphomatous Involvement. ( 29279476 )
2017
6
Spontaneous Unilateral Subperiosteal Hematoma in the Orbit due to Self-Induced Asphyxia: Unusual Cause of Unilateral Exophthalmos. ( 28512426 )
2017
7
Exophthalmos due to sterile neutrophilic dermatosis in a dog. ( 28294507 )
2017
8
Interdisciplinary Management of Minimally Displaced Orbital Roof Fractures: Delayed Pulsatile Exophthalmos and Orbital Encephalocele. ( 28210402 )
2017
9
Exophthalmos associated to orbital zygomatic mucocele and complex maxillary malformation in a puppy. ( 28884074 )
2017
10
Odontogenic parakeratinized cyst resulting in exophthalmos and palatine, maxillary, and zygomatic bone erosion in a dog. ( 29251408 )
2017
11
Exophthalmos and hyperparathyroidism. ( 28750881 )
2017
12
Regression of Ophthalmopathic Exophthalmos in Graves' Disease After Total Thyroidectomy: a Prospective Study of a Surgical Series. ( 29217903 )
2017
13
Treatment of exophthalmos and strabismus surgery in thyroid-associated orbitopathy. ( 26775634 )
2016
14
Mild Camuratia89Engelamann disease presenting with exophthalmos as the first and only manifestation: A case report. ( 27484238 )
2016
15
Exophthalmos (Graves' orbitopathy) in an ancient sculpture. ( 27098805 )
2016
16
Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos. ( 26895762 )
2016
17
Acute Myeloid Leukemia with Initial Presentation of Facial Palsy and Exophthalmos. ( 27411795 )
2016
18
Exophthalmos Revealing a Krukenberg Tumor: A Case Presentation and Review of the Literature. ( 27721760 )
2016
19
A rare cause of exophthalmos in children. ( 26895765 )
2016
20
Exophthalmos, Diplopia, and Bilateral Eyelid Edema: Symptoms of Ocular Mastocytosis. ( 27560850 )
2016
21
Erdheim-Chester Disease Presenting With Intractable Exophthalmos and Bone Lesions. ( 27865309 )
2016
22
The First Reported Case of Erdheim-Chester Disease in Egypt with Bilateral Exophthalmos, Loss of Vision, and Multi-Organ Involvement in a Young Woman. ( 27237445 )
2016
23
Sphenoid Wing Dysplasia with Pulsatile Exophthalmos in Neurofibromatosis Type 1. ( 27280756 )
2016
24
The philosopher Socrates had exophthalmos (a term coined by Plato) and probably Graves' disease. ( 25553768 )
2015
25
Slowly progressive Lemierre's syndrome with orbital pain and exophthalmos. ( 26419364 )
2015
26
Intraorbital Encephalocele Presenting with Exophthalmos and Orbital Dystopia : CT and MRI Findings. ( 25674346 )
2015
27
Radiation therapy as part of the therapeutic regimen for extensive multilocular myxedema in a patient with exophthalmos, myxedema and osteoarthropathy syndrome: A case report. ( 26137080 )
2015
28
Dynamic exophthalmos and lateral strabismus in a dog caused by masticatory muscle myositis. ( 25728848 )
2015
29
Relation of the Vector Force Needed to Lift the Upper Eyelids and the Degree of Exophthalmos. ( 26086928 )
2015
30
A Hypothesis for the Pathologic Mechanism of Idiopathic Exophthalmos Based on Computed Tomographic Evaluations. ( 26114529 )
2015
31
Cholesterol granuloma of a Haller cell associated with unilateral exophthalmos and diplopia. ( 26719083 )
2015
32
Partial thickness autologus calvarial bone orbitocranioplasty for a sphenorbital encephalocele presenting as pulsatile exophthalmos. ( 25972944 )
2015
33
Ethmoid pneumocele presenting with exophthalmos 15 years after endoscopic sinus surgery. ( 26302735 )
2015
34
A mysterious post-traumatic pulsatile exophthalmos. ( 24022797 )
2014
35
Pulsatile exophthalmos: effect of orthostatic pressure difference. ( 24407832 )
2014
36
Exophthalmos Myxedema Acropachy Syndrome: A Case Report. ( 26060688 )
2014
37
Orbital reconstruction for pulsatile exophthalmos secondary to sphenoid wing dysplasia. ( 24835868 )
2014
38
Dural arteriovenous fistula presenting with exophthalmos and seizures. ( 24439472 )
2014
39
Posttraumatic pulsating exophthalmos in a child. ( 24119872 )
2014
40
A new approach to aesthetic maxillofacial surgery: surgical treatment of unilateral exophthalmos due to maxillary sinus mucocele. ( 23714910 )
2013
41
Arachnoid Cyst in the Middle Cranial Fossa Presenting with Pulsatile Exophthalmos: Case Report and Literature Review. ( 24305013 )
2013
42
Case of recurrent exophthalmos: angioedema versus idiopathic orbital pseudotumor. ( 24565625 )
2013
43
Exophthalmos due to odontogenic intraorbital abscess in Cebus apella. ( 23311626 )
2013
44
Fronto-orbital osteoma. Answer to the e-quid "Unilateral exophthalmos in a 30-year-old man". ( 23294927 )
2013
45
CT features of exophthalmos in Chinese subjects with thyroid-associated ophthalmopathy. ( 23638413 )
2013
46
Intradiploic hematoma of the frontal bone with secondary exophthalmos in a mare. ( 23953510 )
2013
47
Exophthalmos: A Forgotten Clinical Sign of Cushing's Syndrome. ( 23555062 )
2013
48
Exophthalmos as a first manifestation of the systemic spread of small cell lung cancer. ( 24059030 )
2013
49
Palpebral ptosis, fixed mydriasis and exophthalmos: an uncommon presentation of new diabetes mellitus. ( 22907808 )
2013
50
Loss of visual acuity on the left eye and ipsilateral exophthalmos in a 68-year-old male patient. ( 24313789 )
2013

Variations for Exophthalmos

Expression for Exophthalmos

Search GEO for disease gene expression data for Exophthalmos.

Pathways for Exophthalmos

Pathways related to Exophthalmos according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.92 FGFR2 FLNA NF1 TGFB1
2 10.67 NF1 TGFB1
3 9.4 TG TSHR

GO Terms for Exophthalmos

Biological processes related to Exophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 digestive tract development GO:0048565 9.46 FGFR2 TGFB1
2 cellular response to ionizing radiation GO:0071479 9.43 RHNO1 TGFB1
3 regulation of multicellular organism growth GO:0040014 9.4 FGFR2 PRL
4 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.37 FGFR2 TGFB1
5 wound healing GO:0042060 9.33 FGFR2 NF1 TGFB1
6 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.32 PRL TGFB1
7 positive regulation of adenylate cyclase activity GO:0045762 9.26 NF1 TSHR
8 negative regulation of neuroblast proliferation GO:0007406 8.96 NF1 TGFB1
9 positive regulation of odontogenesis GO:0042482 8.62 CD34 TGFB1

Sources for Exophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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