Aliases & Classifications for Exostosis

MalaCards integrated aliases for Exostosis:

Name: Exostosis 12 14
Exostoses 41 69 28
Osteophyte 12 69
Cartilaginous Exostosis 69
Swimmer's Exostosis 12
Exostosis of Orbit 69
Orbital Exostosis 12
External Exotoses 69
Bony Outgrowth 12
Bone Spur 12

Classifications:



Summaries for Exostosis

Disease Ontology : 12 A hyperostosis that involves formation of new bone on the surface of preexisting bone.

MalaCards based summary : Exostosis, also known as exostoses, is related to trichorhinophalangeal syndrome, type ii and exostoses, multiple, type i. An important gene associated with Exostosis is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways is heparan sulfate biosynthesis. The drugs Etoricoxib and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and brain.

Wikipedia : 72 An exostosis (plural: exostoses) is the formation of new bone on the surface of a bone. Exostoses can... more...

Related Diseases for Exostosis

Diseases related to Exostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 trichorhinophalangeal syndrome, type ii 32.4 EXT1 EXTL1
2 exostoses, multiple, type i 32.3 EXT1 EXT2
3 hereditary multiple exostoses 31.7 EXT1 EXT2 EXTL1 EXTL3 POMGNT2
4 osteochondroma 31.7 EXT1 EXT2
5 hereditary multiple osteochondromas 30.6 EXT1 EXT2 EXTL1 EXTL3 POMGNT2
6 exostosis, dupuytren subungual 12.0
7 hyperostosis 11.2
8 bicipital tenosynovitis 10.9
9 heel spur 10.9
10 ear exostoses 10.9
11 cervicitis 10.3
12 dysplasia epiphysealis hemimelica 10.2 EXT1 EXT2
13 multiple enchondromatosis, maffucci type 10.2 EXT1 EXT2
14 episodic pain syndrome, familial, 1 10.1
15 aneurysm 10.1
16 chondrosarcoma 10.1
17 trichorhinophalangeal syndrome, type i 10.0 EXT1 EXTL1
18 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.0
19 thrombosis 10.0
20 enchondromatosis, multiple, ollier type 10.0 EXT1 EXT2
21 gingivitis 10.0
22 exostoses, multiple, type ii 9.9
23 periostitis 9.9
24 bone remodeling disease 9.9 BGLAP EXT1 EXT2
25 blood group, i system 9.8
26 osteoid osteoma 9.8
27 aging 9.8
28 brachydactyly 9.8
29 scoliosis 9.8
30 pneumothorax 9.8
31 syringomyelia 9.8
32 hypophosphatasia 9.8
33 fasciitis 9.8
34 plantar fasciitis 9.8
35 cataract 32, multiple types 9.6
36 cataract 5, multiple types 9.6
37 cervical rib 9.6
38 fibrodysplasia ossificans progressiva 9.6
39 legg-calve-perthes disease 9.6
40 neurofibromatosis, type iv, of riccardi 9.6
41 osteoporosis 9.6
42 otitis media 9.6
43 rheumatoid arthritis 9.6
44 schizophrenia 9.6
45 thrombophilia due to thrombin defect 9.6
46 down syndrome 9.6
47 mismatch repair cancer syndrome 9.6
48 osteoarthritis with mild chondrodysplasia 9.6
49 mycobacterium tuberculosis 1 9.6
50 bone mineral density quantitative trait locus 8 9.6

Comorbidity relations with Exostosis via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Exostosis:



Diseases related to Exostosis

Symptoms & Phenotypes for Exostosis

Drugs & Therapeutics for Exostosis

Drugs for Exostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3 Analgesics Phase 4
4 Analgesics, Non-Narcotic Phase 4
5 Analgesics, Opioid Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Anti-Inflammatory Agents, Non-Steroidal Phase 4
8 Antirheumatic Agents Phase 4
9 Central Nervous System Depressants Phase 4
10 Cyclooxygenase 2 Inhibitors Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Narcotics Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Mitogens Phase 2
15
Adalimumab Approved 331731-18-1 16219006
16
Certolizumab pegol Approved 428863-50-7
17
Etanercept Approved, Investigational 185243-69-0
18
Infliximab Approved 170277-31-3
19
Epinephrine Approved, Vet_approved 51-43-4 5816
20
Lidocaine Approved, Vet_approved 137-58-6 3676
21 Racepinephrine Approved 329-65-7
22
Menthol Approved 2216-51-5 16666
23 Anesthetics
24 Anesthetics, General
25 Immunosuppressive Agents
26 Adrenergic Agents
27 Adrenergic Agonists
28 Adrenergic alpha-Agonists
29 Adrenergic beta-Agonists
30 Anesthetics, Local
31 Anti-Arrhythmia Agents
32 Anti-Asthmatic Agents
33 Autonomic Agents
34 Bronchodilator Agents
35 Diuretics, Potassium Sparing
36 Epinephryl borate
37 Mydriatics
38 Neurotransmitter Agents
39 Pharmaceutical Solutions
40 Respiratory System Agents
41 Sodium Channel Blockers
42 Vasoconstrictor Agents
43 Calcium, Dietary
44 Complement C3
45 insulin
46 Insulin, Globin Zinc
47 Calamus Nutraceutical

Interventional clinical trials:

(show all 45)

# Name Status NCT ID Phase Drugs
1 A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
2 The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery Completed NCT00733421 Phase 4 etoricoxib;tramadol
3 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
4 Amniotic Membrane as an Adjunct Treatment for Hallux Rigidus Active, not recruiting NCT01825356 Phase 4
5 Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant Terminated NCT01057641 Phase 4
6 Post-Approval Clinical Trial of the PCM® Cervical Disc Completed NCT01905930 Phase 3
7 Surgical Management of Spinal Cord Injuries In Neck Unknown status NCT00475748 Phase 2
8 Evaluation of Two Types of PRP in Knee Osteoarthritis Recruiting NCT02923310 Phase 1, Phase 2 Hialuronic Acid
9 Autologous Stem Cells in Achilles Tendinopathy Recruiting NCT02064062 Phase 2
10 Flexible Footwear and Insole in Heel Pain Recruiting NCT03040557 Phase 1, Phase 2
11 An Efficacy and Safety Study of Palovarotene for the Treatment of MO Not yet recruiting NCT03442985 Phase 2 Palovarotene 2.5 mg;Palovarotene 5.0 mg
12 Sprifermin (AS902330) in Cartilage Injury Repair (CIR) Terminated NCT01066871 Phase 2 Sprifermin (AS902330) 10 mcg;Sprifermin (AS902330) 30 mcg;Sprifermin (AS902330) 100 mcg
13 A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects With Osteoarthritis of the Knee Completed NCT00456157 Phase 1 Intra-articular Injection of OP-1 to affected knee
14 Patellar Resurfacing Under Subvastus Approach in Total Knee Arthroplasty Unknown status NCT02683460
15 Surgical or Exercise Therapy on Patients With Degenerative Meniscus Tears Unknown status NCT01002794
16 Baxter: Actifuse SHAPE vs DBX in ACC Unknown status NCT02005081
17 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
18 Weight Management and Coping Skills Training For Patients With Knee Osteoarthritis Completed NCT00305890
19 The Three-dimensional Gait Analysis of Medial Knee Osteoarthritis Completed NCT02878239
20 Patellar Resurfacing in Total Knee Arthroplasty Completed NCT00553982
21 Can Shoulder Arthroscopy Work Completed NCT01623011
22 DTI of the Brain and Cervical Spine: Evaluation in Normal Subjects and Patients With Cervical Spondylotic Myelopathy Completed NCT01868958
23 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
24 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698
25 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932
26 High-Resolution Diffusion Tensor Imaging (DTI) of the Cervical Spinal Cord in the Setting of Spinal Cord Injury (SCI) Completed NCT01407705
27 Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and Knee Completed NCT01771393
28 Comparing the Efficacy of Periarticular Bone Structure in Patients Treated With Either Tocilizumab or Tumor Necrosis Factor Blockers Recruiting NCT02778789 Tocilizumab;TNF-alpha Inhibitor
29 Fat Grafting and Retention for Heel Fat Pad Atrophy Recruiting NCT02465333 Local anesthetic
30 Distal Erosions and Nail Psoriasis Recruiting NCT02813720
31 Results of the Treatment of Patients With Elbow Osteoarthritis Recruiting NCT02951403
32 Subchondroplasty® Knee RCT Recruiting NCT03112200
33 Predictors of Outcome and Natural History in Patients With Cervical Spondylotic Myelopathy Recruiting NCT02936245
34 The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry Recruiting NCT02745158
35 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Recruiting NCT02934100
36 Change of Lumbar Symptom After Surgical Treatment for Patients With Cervical Stenosis Recruiting NCT03089931
37 Application of Radiostereometric Analysis (RSA) to Triathlon Knee Components Inserted Using the OtisMed Custom-fit Total Knee Replacement System Active, not recruiting NCT01262430
38 Cervical Spondylotic Myelopathy Surgical Trial Active, not recruiting NCT02076113
39 The Norwegian Cervical Arthroplasty Trial Active, not recruiting NCT00735176
40 RHINE™ Cervical Disc Clinical Study: A Prospective Observational Study for Patients Requiring 1-2 Level C-spine Surgery Enrolling by invitation NCT02403453
41 The Histological Effect of Various Microfracture Techniques on Human Chondral & Sub-chondral Tissue - an Ex-Vivo Study Not yet recruiting NCT03016299
42 Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH) Not yet recruiting NCT03237455
43 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
44 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850
45 ACP for Local Application in Ankle Arthrodesis Terminated NCT01131455

Search NIH Clinical Center for Exostosis

Cochrane evidence based reviews: exostoses

Genetic Tests for Exostosis

Genetic tests related to Exostosis:

# Genetic test Affiliating Genes
1 Exostoses 28

Anatomical Context for Exostosis

MalaCards organs/tissues related to Exostosis:

38
Bone, Spinal Cord, Brain, Lung, B Cells, Testes, Skin

Publications for Exostosis

Articles related to Exostosis:

(show top 50) (show all 458)
# Title Authors Year
1
Subungual exostosis on index finger in a child. ( 29350203 )
2018
2
Transcanal Approach with Osteotomy Versus Retroauricular Approach with Microdrill for Canaplasty in Exostosis and Osteomas. ( 28333780 )
2017
3
Popliteal artery pseudoaneurysm due to femur exostosis. ( 28350211 )
2017
4
Bilateral maxillary and mandibular buccal exostosis: a self reported case and a proposal to include buccal exostosis under miscellaneous disorders of revised working classification of the psychosomatic disorders pertaining to dental practice. ( 28416999 )
2017
5
Spontaneous Haemothorax Secondary to Rib Exostosis. ( 28343950 )
2017
6
Dermoscopy of Subungual Exostosis: A Retrospective Study of 10 Patients. ( 28482347 )
2017
7
Can an exostosis be free floating without any continuity to the underlying bone: A diagnostic dilemma. ( 29339849 )
2017
8
Haberland Syndrome Associated With Calvarial Exostosis. ( 28863121 )
2017
9
Acquired exostosis: a case report and review of literature. ( 28922700 )
2017
10
Prevalence of oral tori and exostosis in Malaysian population - A cross-sectional study. ( 29123992 )
2017
11
Painful and swollen hands 3A months after lungs graft: Suracute voriconazole-induced periostitis and exostosis. ( 27117297 )
2016
12
Awareness and attitudes towards external auditory canal exostosis and its preventability in surfers in the UK: cross-sectional study. ( 27263424 )
2016
13
Case Report of the positive exostosin-1 without B-cell lymphoma-2 gene expression of giant cell tumor lesion in hereditary multiple exostosis. ( 27846455 )
2016
14
Popliteal artery thrombosis complicating posterior tibial exostosis in a 35-year-old male. ( 26993856 )
2016
15
Oral pathology: Exostosis deforming face features. ( 27444586 )
2016
16
Syringomyelia in Hereditary Multiple Exostosis. ( 27480811 )
2016
17
Bilateral Scapulothoracic Osteochondromas in a Patient With Hereditary Multiple Exostosis: A Case Report and Review of the Literature. ( 27761218 )
2016
18
Rare Mimickers of Exostosis: A Case Series. ( 27630926 )
2016
19
External ear canal exostosis and otitis media in temporal bones of prehistoric and historic chilean populations. A paleopathological and paleoepidemiological study. ( 27834109 )
2016
20
Dystrophy of the Great Toenail by Subungual Exostosis and Hyperostosis: Three Case Reports with Different Clinical Presentations. ( 27386469 )
2016
21
Total Hip Arthroplasty Using a Polished Tapered Cemented Stem in Hereditary Multiple Exostosis. ( 27127668 )
2016
22
Concurrence of Torus Palatinus, Torus Mandibularis and Buccal Exostosis. ( 28666499 )
2016
23
Subungual exostosis. ( 27622256 )
2016
24
Surgical Outcomes for Resection of the Dorsal Exostosis of the Metatarsocuneiform Joints. ( 26872522 )
2016
25
Asymptomatic costal exostosis with thickening in the pericardium: a case report. ( 26946299 )
2016
26
Exostosis Bursata - Multimodality Imaging Approach. ( 27790547 )
2016
27
Correction of ankle valgus by hemiepiphysiodesis using the tension band principle in patients with multiple hereditary exostosis. ( 27234571 )
2016
28
Intermediate grade vertebral osteosarcoma in a patient affected by a sacral chondrosarcoma and hereditary multiple exostosis. ( 25901365 )
2015
29
IMAGES IN CLINICAL MEDICINE. Oral Maxillary Exostosis. ( 26444732 )
2015
30
Deep vein thrombosis caused by an exostosis in an adolescent patient with peripheral neurofibromatosis type 1. ( 26098328 )
2015
31
Resection of costal exostosis using piezosurgery associated with uniportal video-assisted thoracoscopy. ( 25742839 )
2015
32
Atraumatic Removal of Mandibular Exostosis. ( 26591495 )
2015
33
Surgical treatment of nail bed subungual exostosis. ( 26778465 )
2015
34
Osteochondroma of Upper Dorsal Spine Causing Spastic Paraparesis in Hereditary Multiple Exostosis: A Case Report. ( 26816957 )
2015
35
Femoral exostosis causing vastus medialis pain in an active young lady: a case report. ( 25889418 )
2015
36
Identification of a novel EXT1 mutation in patients with hereditary multiple exostosis by exome sequencing. ( 25421355 )
2015
37
Surgical management of the bilateral maxillary buccal exostosis. ( 26229284 )
2015
38
Painful exostosis of the external occipital protuberance. ( 26261091 )
2015
39
Buccal exostosis: a rare entity. ( 26028907 )
2015
40
False Arterial Aneurysm due to Long Bone Exostosis: Presentation of Two Cases and Update on Proper Management. ( 25733214 )
2015
41
ISCHIOFEMORAL IMPINGEMENT DUE TO A SOLITARY EXOSTOSIS. ( 26223065 )
2015
42
Fibrodysplasia ossificans progressiva misdiagnosed as cervical exostosis. ( 25832962 )
2015
43
A Novel Cause of Acute Coronary Syndrome Due to Dynamic Extrinsic Coronary Artery Compression by a Rib Exostosis: Multimodality Imaging Diagnosis. ( 26255213 )
2015
44
Reconstruction of the DRUJ in a young adult after resection of a large exostosis of the distal radius. ( 25877933 )
2015
45
Exostosis masquerading as a subungual wart. ( 24616871 )
2014
46
The effects of surfing behaviour on the development of external auditory canal exostosis. ( 24619201 )
2014
47
Traumatic hemothorax caused by solitary costal exostosis. ( 24439464 )
2014
48
Timing of forearm deformity correction in a child with multiple hereditary exostosis. ( 25251529 )
2014
49
Giant spinal exostosis. ( 24810455 )
2014
50
Bone tuberculosis simulating an exostosis. ( 25392719 )
2014

Variations for Exostosis

Expression for Exostosis

Search GEO for disease gene expression data for Exostosis.

Pathways for Exostosis

Pathways related to Exostosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.76 EXT1 EXT2 EXTL1 EXTL3

GO Terms for Exostosis

Cellular components related to Exostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.35 EXT1 EXT2 EXTL1 EXTL3 POMGNT2
2 endoplasmic reticulum lumen GO:0005788 9.33 BGLAP COL12A1 COL4A5
3 collagen trimer GO:0005581 9.26 COL12A1 COL4A5
4 endoplasmic reticulum membrane GO:0005789 9.02 EXT1 EXT2 EXTL1 EXTL3 POMGNT2

Biological processes related to Exostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.54 BGLAP EXT1 EXT2
2 collagen catabolic process GO:0030574 9.46 COL12A1 COL4A5
3 skeletal system development GO:0001501 9.46 BGLAP COL12A1 EXT1 EXTL1
4 IRE1-mediated unfolded protein response GO:0036498 9.43 EXTL1 EXTL3
5 glycosaminoglycan biosynthetic process GO:0006024 9.4 EXT1 EXT2
6 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.32 EXT1 EXT2
7 cellular polysaccharide biosynthetic process GO:0033692 9.26 EXT1 EXT2
8 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.13 EXT1 EXT2 EXTL3
9 protein glycosylation GO:0006486 9.02 EXT1 EXT2 EXTL1 EXTL3 POMGNT2

Molecular functions related to Exostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.8 EXT1 EXT2 EXTL1 EXTL3 POMGNT2
2 glucuronosyltransferase activity GO:0015020 9.37 EXT1 EXT2
3 transferase activity, transferring glycosyl groups GO:0016757 9.35 EXT1 EXT2 EXTL1 EXTL3 POMGNT2
4 acetylglucosaminyltransferase activity GO:0008375 9.33 EXT1 EXT2 POMGNT2
5 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.32 EXT1 EXT2
6 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 9.26 EXT1 EXT2
7 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 8.8 EXT1 EXT2 EXTL1

Sources for Exostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....