Aliases & Classifications for Exostosis

Aliases & Descriptions for Exostosis:

Name: Exostosis 12 14
Osteophyte 12 69
Exostoses 42 69
Cartilaginous Exostosis 69
Swimmer's Exostosis 12
Exostosis of Orbit 69
Orbital Exostosis 12
External Exotoses 69
Bony Outgrowth 12
Bone Spur 12

Classifications:



External Ids:

Disease Ontology 12 DOID:203
ICD10 33 M27.8 M25.7
ICD9CM 35 726.91
MeSH 42 D005096
NCIt 47 C3029
UMLS 69 C1442903

Summaries for Exostosis

Disease Ontology : 12 A hyperostosis that involves formation of new bone on the surface of preexisting bone.

MalaCards based summary : Exostosis, also known as osteophyte, is related to trichorhinophalangeal syndrome, type ii and dupuytren subungual exostosis. An important gene associated with Exostosis is EXT1 (Exostosin Glycosyltransferase 1), and among its related pathways/superpathways is heparan sulfate biosynthesis. The drugs Etoricoxib and Tramadol have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and lung.

Wikipedia : 71 An exostosis (plural: exostoses) is the formation of new bone on the surface of a bone. Exostoses can... more...

Related Diseases for Exostosis

Diseases related to Exostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
id Related Disease Score Top Affiliating Genes
1 trichorhinophalangeal syndrome, type ii 30.9 EXT1 EXT2 EXTL1 EXTL3
2 dupuytren subungual exostosis 11.8
3 hereditary multiple exostoses 11.7
4 osteochondroma 11.2
5 hyperostosis 11.1
6 hereditary multiple osteochondromas 10.9
7 exostoses, multiple, type 1 10.9
8 bicipital tenosynovitis 10.8
9 heel spur 10.8
10 cervicitis 10.2
11 erythroderma, lethal congenital 10.2 EXT1 EXT2
12 neuropathy, ataxia, and retinitis pigmentosa 10.1 EXT1 EXT2
13 burkitt lymphoma 10.1 EXT1 EXTL1
14 macrosomia with microphthalmia, lethal 10.1 EXT1 EXT2
15 ovarian epithelial cancer 10.1 EXT1 EXT2
16 aneurysm 10.0
17 intrahepatic cholestasis 10.0 BGLAP EXT1
18 chondrosarcoma 10.0
19 ischemic bone disease 10.0 BGLAP EXT1 EXT2
20 thrombosis 9.9
21 malignant adult ependymoma 9.9 BGLAP EXT2
22 gingivitis 9.9
23 periostitis 9.8
24 vulvar syringoma 9.7 EXT1 EXT2 EXTL1 EXTL3 POMGNT2
25 isolated gonadotropin-releasing hormone deficiency 9.7 EXT1 EXT2 EXTL1 EXTL3 POMGNT2
26 scoliosis 9.7
27 syringomyelia 9.7
28 pneumothorax 9.7
29 brachydactyly 9.7
30 fasciitis 9.7
31 plantar fasciitis 9.7
32 hypophosphatasia 9.7
33 fibrodysplasia ossificans progressiva 9.5
34 osteoporosis 9.5
35 bursitis 9.5
36 osteomyelitis 9.5
37 astrocytoma 9.5
38 frontal sinusitis 9.5
39 otosclerosis 9.5
40 lipomatosis 9.5
41 otitis media 9.5
42 tarsal tunnel syndrome 9.5
43 ischemia 9.5
44 legg-calve-perthes disease 9.5
45 quadriplegia 9.5
46 spastic paraparesis 9.5
47 neurofibromatosis, type 1 9.5
48 cranial nerve palsy 9.5
49 encephalocraniocutaneous lipomatosis 9.5
50 tuberculosis 9.5

Comorbidity relations with Exostosis via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Exostosis:



Diseases related to Exostosis

Symptoms & Phenotypes for Exostosis

Drugs & Therapeutics for Exostosis

Drugs for Exostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
2
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
3 Analgesics Phase 4
4 Narcotics Phase 4
5 Cyclooxygenase 2 Inhibitors Phase 4
6 Cyclooxygenase Inhibitors Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Analgesics, Opioid Phase 4
9 Peripheral Nervous System Agents Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Antirheumatic Agents Phase 4
13 Central Nervous System Depressants Phase 4
14 Mitogens Phase 2
15
Epinephrine Approved, Vet_approved 51-43-4 5816
16
Adalimumab Approved 331731-18-1 16219006
17
Etanercept Approved, Investigational 185243-69-0
18
Infliximab Approved 170277-31-3
19
Lidocaine Approved, Vet_approved 137-58-6 3676
20
Menthol Approved 2216-51-5 16666
21
Certolizumab pegol Approved 428863-50-7
22 Anesthetics
23 Anesthetics, General
24 Mydriatics
25 Adrenergic Agents
26 Adrenergic Agonists
27 Sodium Channel Blockers
28 Adrenergic alpha-Agonists
29 Adrenergic beta-Agonists
30 Neurotransmitter Agents
31 Diuretics, Potassium Sparing
32 Anesthetics, Local
33 Vasoconstrictor Agents
34 Epinephryl borate
35 Pharmaceutical Solutions
36 Anti-Arrhythmia Agents
37 Anti-Asthmatic Agents
38 Immunosuppressive Agents
39 Racepinephrine
40 Respiratory System Agents
41 Autonomic Agents
42 Bronchodilator Agents
43 Calcium, Dietary
44 Calamus Nutraceutical

Interventional clinical trials:

(show all 43)
id Name Status NCT ID Phase
1 A Randomized Trial to Evaluate the Effectiveness of Transferring the Flexor Hallucis Longus Tendon Unknown status NCT01341509 Phase 4
2 The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery Completed NCT00733421 Phase 4
3 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer Completed NCT00950053 Phase 4
4 Amniotic Membrane as an Adjunct Treatment for Hallux Rigidus Active, not recruiting NCT01825356 Phase 4
5 Study on the Treatment of Degenerative Lumbar Spine Stenosis With a Percutaneous Interspinous Implant Terminated NCT01057641 Phase 4
6 Post-Approval Clinical Trial of the PCM® Cervical Disc Completed NCT01905930 Phase 3
7 Surgical Management of Spinal Cord Injuries In Neck Unknown status NCT00475748 Phase 2
8 Evaluation of Two Types of PRP in Knee Osteoarthritis Recruiting NCT02923310 Phase 1, Phase 2
9 Autologous Stem Cells in Achilles Tendinopathy Recruiting NCT02064062 Phase 2
10 Flexible Footwear and Insole in Heel Pain Recruiting NCT03040557 Phase 1, Phase 2
11 Sprifermin (AS902330) in Cartilage Injury Repair (CIR) Terminated NCT01066871 Phase 2
12 A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects With Osteoarthritis of the Knee Completed NCT00456157 Phase 1
13 Surgical or Exercise Therapy on Patients With Degenerative Meniscus Tears Unknown status NCT01002794
14 Can Shoulder Arthroscopy Work Unknown status NCT01623011
15 The Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses Completed NCT00474448
16 Weight Management and Coping Skills Training For Patients With Knee Osteoarthritis Completed NCT00305890
17 The Three-dimensional Gait Analysis of Medial Knee Osteoarthritis Completed NCT02878239
18 Patellar Resurfacing in Total Knee Arthroplasty Completed NCT00553982
19 DTI of the Brain and Cervical Spine: Evaluation in Normal Subjects and Patients With Cervical Spondylotic Myelopathy Completed NCT01868958
20 A Comparison of the Analgesic Efficacies of Ultrasound and Shock Wave Therapy in the Patients With Calcaneal Spur Completed NCT01510249
21 Effects of Myofascial Trigger Point Dry Cupping on Plantar Heel Pain Completed NCT02895698
22 Effectiveness of Manual Therapy Combined With Standard Treatment in the Management of Plantar Fasciitis Completed NCT01439932
23 High-Resolution Diffusion Tensor Imaging (DTI) of the Cervical Spinal Cord in the Setting of Spinal Cord Injury (SCI) Completed NCT01407705
24 Cone-beam vs Multidetector Computed Tomography (CT) for Arthrography of the Wrist, Ankle, Elbow and Knee Completed NCT01771393
25 Comparing the Efficacy of Periarticular Bone Structure in Patients Treated With Either Tocilizumab or Tumor Necrosis Factor Blockers Recruiting NCT02778789
26 Fat Grafting and Retention for Heel Fat Pad Atrophy Recruiting NCT02465333
27 Cervical Spondylotic Myelopathy Surgical Trial Recruiting NCT02076113
28 Distal Erosions and Nail Psoriasis Recruiting NCT02813720
29 Results of the Treatment of Patients With Elbow Osteoarthritis Recruiting NCT02951403
30 Subchondroplasty® Knee RCT Recruiting NCT03112200
31 Baxter: Actifuse SHAPE vs DBX in ACC Recruiting NCT02005081
32 Predictors of Outcome and Natural History in Patients With Cervical Spondylotic Myelopathy Recruiting NCT02936245
33 The Fibrodysplasia Ossificans Progressiva (FOP) Connection Registry Recruiting NCT02745158
34 Evaluation of Effectiveness of Selected Physical and Kinesiotherapeutic Methods in Patients With Lower Calcaneal Spur Recruiting NCT02934100
35 Change of Lumbar Symptom After Surgical Treatment for Patients With Cervical Stenosis Recruiting NCT03089931
36 Application of Radiostereometric Analysis (RSA) to Triathlon Knee Components Inserted Using the OtisMed Custom-fit Total Knee Replacement System Active, not recruiting NCT01262430
37 The Norwegian Cervical Arthroplasty Trial Active, not recruiting NCT00735176
38 RHINE™ Cervical Disc Clinical Study: A Prospective Observational Study for Patients Requiring 1-2 Level C-spine Surgery Enrolling by invitation NCT02403453
39 The Histological Effect of Various Microfracture Techniques on Human Chondral & Sub-chondral Tissue - an Ex-Vivo Study Not yet recruiting NCT03016299
40 Patellar Resurfacing Under Subvastus Approach in Total Knee Arthroplasty Not yet recruiting NCT02683460
41 Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project Suspended NCT00474331
42 Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC Terminated NCT00473850
43 ACP for Local Application in Ankle Arthrodesis Terminated NCT01131455

Search NIH Clinical Center for Exostosis

Cochrane evidence based reviews: exostoses

Genetic Tests for Exostosis

Anatomical Context for Exostosis

MalaCards organs/tissues related to Exostosis:

39
Bone, Spinal Cord, Lung, Testes, Skin, B Cells, Breast

Publications for Exostosis

Articles related to Exostosis:

(show top 50) (show all 447)
id Title Authors Year
1
Case Report of the positive exostosin-1 without B-cell lymphoma-2 gene expression of giant cell tumor lesion in hereditary multiple exostosis. ( 27846455 )
2016
2
Popliteal artery thrombosis complicating posterior tibial exostosis in a 35-year-old male. ( 26993856 )
2016
3
Exostosis Bursata - Multimodality Imaging Approach. ( 27790547 )
2016
4
Asymptomatic costal exostosis with thickening in the pericardium: a case report. ( 26946299 )
2016
5
Painful and swollen hands 3A months after lungs graft: Suracute voriconazole-induced periostitis and exostosis. ( 27117297 )
2016
6
External ear canal exostosis and otitis media in temporal bones of prehistoric and historic chilean populations. A paleopathological and paleoepidemiological study. ( 27834109 )
2016
7
Correction of ankle valgus by hemiepiphysiodesis using the tension band principle in patients with multiple hereditary exostosis. ( 27234571 )
2016
8
Awareness and attitudes towards external auditory canal exostosis and its preventability in surfers in the UK: cross-sectional study. ( 27263424 )
2016
9
Rare Mimickers of Exostosis: A Case Series. ( 27630926 )
2016
10
Dystrophy of the Great Toenail by Subungual Exostosis and Hyperostosis: Three Case Reports with Different Clinical Presentations. ( 27386469 )
2016
11
Surgical Outcomes for Resection of the Dorsal Exostosis of the Metatarsocuneiform Joints. ( 26872522 )
2016
12
Oral pathology: Exostosis deforming face features. ( 27444586 )
2016
13
Syringomyelia in Hereditary Multiple Exostosis. ( 27480811 )
2016
14
Subungual exostosis. ( 27622256 )
2016
15
Total Hip Arthroplasty Using a Polished Tapered Cemented Stem in Hereditary Multiple Exostosis. ( 27127668 )
2016
16
Bilateral Scapulothoracic Osteochondromas in a Patient With Hereditary Multiple Exostosis: A Case Report and Review of the Literature. ( 27761218 )
2016
17
Intermediate grade vertebral osteosarcoma in a patient affected by a sacral chondrosarcoma and hereditary multiple exostosis. ( 25901365 )
2015
18
Femoral exostosis causing vastus medialis pain in an active young lady: a case report. ( 25889418 )
2015
19
False Arterial Aneurysm due to Long Bone Exostosis: Presentation of Two Cases and Update on Proper Management. ( 25733214 )
2015
20
Identification of a novel EXT1 mutation in patients with hereditary multiple exostosis by exome sequencing. ( 25421355 )
2015
21
Reconstruction of the DRUJ in a young adult after resection of a large exostosis of the distal radius. ( 25877933 )
2015
22
IMAGES IN CLINICAL MEDICINE. Oral Maxillary Exostosis. ( 26444732 )
2015
23
ISCHIOFEMORAL IMPINGEMENT DUE TO A SOLITARY EXOSTOSIS. ( 26223065 )
2015
24
Fibrodysplasia ossificans progressiva misdiagnosed as cervical exostosis. ( 25832962 )
2015
25
A Novel Cause of Acute Coronary Syndrome Due to Dynamic Extrinsic Coronary Artery Compression by a Rib Exostosis: Multimodality Imaging Diagnosis. ( 26255213 )
2015
26
Resection of costal exostosis using piezosurgery associated with uniportal video-assisted thoracoscopy. ( 25742839 )
2015
27
Surgical management of the bilateral maxillary buccal exostosis. ( 26229284 )
2015
28
Buccal exostosis: a rare entity. ( 26028907 )
2015
29
Surgical treatment of nail bed subungual exostosis. ( 26778465 )
2015
30
Atraumatic Removal of Mandibular Exostosis. ( 26591495 )
2015
31
Deep vein thrombosis caused by an exostosis in an adolescent patient with peripheral neurofibromatosis type 1. ( 26098328 )
2015
32
Painful exostosis of the external occipital protuberance. ( 26261091 )
2015
33
Osteochondroma of Upper Dorsal Spine Causing Spastic Paraparesis in Hereditary Multiple Exostosis: A Case Report. ( 26816957 )
2015
34
Subungual exostosis. ( 24787537 )
2014
35
Symptomatic hip impingement due to exostosis associated with supra-acetabular pelvic external fixator pin. ( 24490184 )
2014
36
[Mutation analysis of EXT2 gene in a family with hereditary multiple exostosis]. ( 25449079 )
2014
37
Exostosis of the Internal Auditory Canal: 10-Year Follow-Up. ( 25440938 )
2014
38
Exostosis of the optic canal in a child--a rare diagnosis in a paediatric ear, nose and throat setting: a case report. ( 25528154 )
2014
39
Mandibular exostosis in canine with single tooth recession - a rare case report. ( 25214741 )
2014
40
Rebound of Ankle Valgus Deformity in Patients With Hereditary Multiple Exostosis. ( 24978121 )
2014
41
The effects of surfing behaviour on the development of external auditory canal exostosis. ( 24619201 )
2014
42
Syringomyelia and vertebral osteochondromas in patients with multiple hereditary exostosis. ( 24977942 )
2014
43
Giant spinal exostosis. ( 24810455 )
2014
44
Timing of forearm deformity correction in a child with multiple hereditary exostosis. ( 25251529 )
2014
45
Traumatic hemothorax caused by solitary costal exostosis. ( 24439464 )
2014
46
Protruded and nonprotruded subungual exostosis: Differences in surgical approach. ( 24600063 )
2014
47
Exostosis masquerading as a subungual wart. ( 24616871 )
2014
48
Bone tuberculosis simulating an exostosis. ( 25392719 )
2014
49
Subungual exostosis. ( 24036655 )
2013
50
Pseudoaneurysm of the popliteal artery in a child with multiple hereditary exostosis: a rare case report and literature review. ( 23748578 )
2013

Variations for Exostosis

Expression for Exostosis

Search GEO for disease gene expression data for Exostosis.

Pathways for Exostosis

Pathways related to Exostosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.76 EXT1 EXT2 EXTL1 EXTL3

GO Terms for Exostosis

Cellular components related to Exostosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.35 EXT1 EXT2 EXTL1 EXTL3 POMGNT2
2 endoplasmic reticulum lumen GO:0005788 9.33 BGLAP COL12A1 COL4A5
3 collagen trimer GO:0005581 9.26 COL12A1 COL4A5
4 endoplasmic reticulum membrane GO:0005789 9.02 EXT1 EXT2 EXTL1 EXTL3 POMGNT2

Biological processes related to Exostosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein glycosylation GO:0006486 9.62 EXT1 EXT2 EXTL1 POMGNT2
2 ossification GO:0001503 9.58 BGLAP EXT1 EXT2
3 collagen catabolic process GO:0030574 9.46 COL12A1 COL4A5
4 skeletal system development GO:0001501 9.46 BGLAP COL12A1 EXT1 EXTL1
5 IRE1-mediated unfolded protein response GO:0036498 9.43 EXTL1 EXTL3
6 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.37 EXT1 EXT2
7 cellular polysaccharide biosynthetic process GO:0033692 9.26 EXT1 EXT2
8 glycosaminoglycan biosynthetic process GO:0006024 9.26 EXT1 EXT2 EXTL1 EXTL3
9 heparan sulfate proteoglycan biosynthetic process GO:0015012 8.92 EXT1 EXT2 EXTL1 EXTL3

Molecular functions related to Exostosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.8 EXT1 EXT2 EXTL1 EXTL3 POMGNT2
2 glucuronosyltransferase activity GO:0015020 9.37 EXT1 EXT2
3 transferase activity, transferring glycosyl groups GO:0016757 9.35 EXT1 EXT2 EXTL1 EXTL3 POMGNT2
4 acetylglucosaminyltransferase activity GO:0008375 9.33 EXT1 EXT2 POMGNT2
5 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 9.32 EXT1 EXT2
6 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.26 EXT1 EXT2
7 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 8.8 EXT1 EXT2 EXTL1

Sources for Exostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....