Exotropia malady

Wikipedia: Exotropia (from Greek εξοτρὀπια, εξο \"exo\" meaning \"to exit\" or \"move out of\" and...⁴⁴ more...

MalaCards: Exotropia, also known as divergent concomitant strabismus (disorder), is related to congenital central hypoventilation syndrome and hypotropia. An important gene associated with Exotropia is AMTN (amelotin).

Aliases & Descriptions:

exotropia 6 8 43 divergent concomitant strabismus (disorder) 6 divergent concomitant strabismus 6 unspecified exotropia (disorder) 6

exotropia nos (disorder) 6 exotropia, unspecified 6 exotropia (disorder) 6 divergent strabismus 6

Diseases related to exotropia by text searches and GeneDecks gene sharing:

id	Related Disease	Score	Top Affiliating Genes
1	congenital central hypoventilation syndrome	12.7	PHOX2B, PHOX2A
2	hypotropia	12.7	MC1R, PHOX2A
3	central hypoventilation syndrome	12.5	PHOX2A, PHOX2B
4	nystagmus	12.3	LMLN, MC1R
5	esotropia	12.2	KCNV2, LMLN, SEMA7A
6	x-linked infantile nystagmus	12.1	LMLN, KCNV2, MC1R
7	alternating exotropia	7.3
8	monocular exotropia	7.3

Approved drugs:

Drug clinical trials:

Articles related to exotropia:

id	Title	Authors	Year	Affiliating Genes
1	Clinical correlations of aggrecan in the resected medial rectus muscle of patients with intermittent exotropia. (14627072)	Yamane T.... Ohtsuki H.	2003	ACAN

Genes related to exotropia according to GeneCards:

(show all 12)

id	Symbol	Description	Score	GeneCards Section Context
1	AMTN	amelotin	11.0	Disorders
2	CTU2	cytosolic thiouridylase subunit 2 homolog (S. pombe)	11.0	Disorders
3	PHOX2A	paired-like homeobox 2a	11.0
4	KCNV2	potassium channel, subfamily V, member 2	11.0	Disorders
5	DPAGT1	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	11.0	Disorders
6	PHOX2B	paired-like homeobox 2b	11.0
7	SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	11.0	Disorders
8	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	11.0	Disorders
9	LMLN	leishmanolysin-like (metallopeptidase M8 family)	11.0
10	NT5C3	5'-nucleotidase, cytosolic III	11.0
11	ACAN	aggrecan	11.0	Publications
12	MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	11.0

Biological processes related to exotropia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	parasympathetic nervous system development	GO:048486	9.9	PHOX2A, PHOX2B
2	noradrenergic neuron differentiation	GO:003357	9.8	PHOX2A, PHOX2B
3	dopaminergic neuron differentiation	GO:071542	9.7	PHOX2A, PHOX2B
4	sympathetic nervous system development	GO:048485	9.5	PHOX2B, PHOX2A
5	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.8	FOXC2, MC1R, PHOX2A, PHOX2B

Molecular functions related to exotropia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	RNA polymerase II regulatory region sequence-specific DNA binding	GO:000977	9.8	PHOX2A, PHOX2B