MCID: EXT022
MIFTS: 40

Exotropia malady

Eye diseases category

Summaries for Exotropia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Exotropia (from Greek εξοτρὀπια, εξο \"exo\" meaning \"to exit\" or \"move out of\" and... more...

MalaCards: Exotropia, also known as divergent concomitant strabismus, is related to esotropia and congenital nystagmus. An important gene associated with Exotropia is PHOX2A (paired-like homeobox 2a). The compound tunicamycin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid, and related mouse phenotype respiratory system.

Aliases & Classifications for Exotropia

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

exotropia 8 10 60
divergent concomitant strabismus 8
exotropia, unspecified 8
unspecified exotropia 8
divergent strabismus 8
exotropia nos 8


External Ids:

Disease Ontology8 DOID:1143
NCIt39 C34601
ICD9CM27 378.1, 378.10
MeSH34 D005099
ICD1025 H50.1

Related Diseases for Exotropia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Exotropia:



Diseases related to exotropia

Clinical Features for Exotropia

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Drugs & Therapeutics for Exotropia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Exotropia

Search CenterWatch for Exotropia

Genetic Tests for Exotropia

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Anatomical Context for Exotropia

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32MalaCards
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MalaCards organs/tissues related to Exotropia:

32
Eye, Testes, Thyroid

Animal Models for Exotropia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Exotropia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.0ACAN, PHOX2B, PHOX2A, FOXC2

Publications for Exotropia

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50PubMed
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Articles related to Exotropia:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Acute onset of upbeat nystagmus, exotropia, and internuclear ophthalmoplegia--a tell-tale of ponto-mesencephalic infarct. (23830476)
2013
2
Ocular torsion among patients with intermittent exotropia: relationships with disease severity factors. (23022165)
2013
3
Associations between Health-Related Quality of Life and the Decision to Perform Surgery for Childhood Intermittent Exotropia. (24314840)
2013
4
Bilateral lateral rectus muscle recession with medial rectus pulley fixation for divergence excess intermittent exotropia with high AC/A ratio. (23791407)
2013
5
Initial postoperative deviation as a predictor of long-term outcome after surgery for intermittent exotropia. (21665502)
2011
6
Characteristics of divergence excess type intermittent exotropia in Asian children. (21963762)
2011
7
Decreased accommodative response in the nondominant eye of patients with intermittent exotropia. (20970775)
2011
8
Single vision during ocular deviation in intermittent exotropia. (21158884)
2011
9
The use of distance stereoacuity assessment in determining the effectiveness of minus lenses in intermittent exotropia. (21093332)
2010
10
Sensorial strabismus due to congenital toxoplasmosis. Is it an eso- or exotropia? (20923407)
2010
11
The fixation target influences the near deviation and AC/A ratio in intermittent exotropia. (20227618)
2010
12
Large-angle congenital exotropia due to 'absent' medial recti: a case of congenital cranial dysinnervation disorder. (18600250)
2009
13
Intervention for intermittent distance exotropia with overcorrecting minus lenses. (18064054)
2009
14
Orbital heterotopic glial tissue presenting as exotropia. (18569821)
2008
15
Factors affecting the surgical outcome of primary exotropia. (18788062)
2008
16
Bilateral Medical Rectus Advancement versus Bilateral Lateral Rectus Recession for Consecutive Exotropia. (23479533)
2008
17
The effect of unilateral medial rectus muscle resection in patients with recurrent exotropia. (18784445)
2008
18
Dissociated vertical deviation in patients with intermittent exotropia. (18329927)
2008
19
Parry-Romberg syndrome presenting with recurrent exotropia and torticollis. (19043950)
2008
20
Factors affecting the surgical outcome of primary exotropia. (17763248)
2007
21
Exotropia and face turn in children with homonymous hemianopia. (18090567)
2007
22
Binocular photophobia after surgical treatment in intermittent exotropia. (18091309)
2007
23
The natural history of surgically untreated intermittent exotropia-looking into the distant future. (16814175)
2006
24
The long-term result of slanted medial rectus resection in exotropia of the convergence insufficiency type. (16151478)
2006
25
Bilateral lateral rectus recession versus unilateral recess-resect procedure for exotropia with a dominant eye. (16564803)
2006
26
The course of intermittent exotropia in a population-based cohort. (16647128)
2006
27
Long-term outcome of patients with large overcorrection following surgery for exotropia. (16088244)
2005
28
Clinical features and surgical treatment of A-pattern exotropia. (15499724)
2004
29
Management of intermittent exotropia. (11859921)
2002
30
Management of intermittent exotropia. (12148549)
2002
31
Relationship between motor alignment at postoperative day 1 and at year 1 after symmetric and asymmetric surgery in intermittent exotropia. (11313049)
2001
32
Bilateral lateral rectus recession for consecutive exotropia. (11040479)
2000
33
Classification and desirable result in intermittent exotropia. (10406165)
1999
34
Infantile exotropia. (8965243)
1996
35
Results of surgery for paralytic exotropia due to oculomotor palsy. (8738461)
1996
36
Episodic exotropia from lateral rectus neuromyotonia--appearance and remission after radiation therapy for a thalamic glioma. (8455129)
1993
37
Monocular eye closure in intermittent exotropia. (3390058)
1988
38
Suppression and retinal correspondence in intermittent exotropia. (3756124)
1986
39
A complication in weakening the superior oblique muscle in A-pattern exotropia. (6709288)
1984
40
Stimulus and response AC/A ratios in intermittent exotropia of the divergence-excess type. (7082610)
1982
41
Functional amblyopia in kittens with unilateral exotropia. I. Electrophysiological assessment. (7428883)
1980
42
The value of diagnostic occlusion for intermittent exotropia. (1200471)
1975
43
Management of adult patients with large angle amblyopic exotropia. (4683790)
1973
44
Surgery, fusion, and accommodative convergence in exotropia. (5155088)
1971
45
A-exotropia, alternating sursumduction, and superior oblique overaction. (5774251)
1969
46
The association of blinks and refusion in intermittent exotropia. (5243950)
1968
47
The management of large angle exotropia. (5678383)
1968
48
Physiology of intermittent exotropia. (13957304)
1963
49
The surgical management of secondary exotropia. (13695307)
1961
50
Intermittent exotropia. (13859440)
1961

Genetic Variations for Exotropia

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Expression for genes affiliated with Exotropia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Exotropia

Search GEO for disease gene expression data for Exotropia.

Pathways for genes affiliated with Exotropia

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Compounds for genes affiliated with Exotropia

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44Novoseek, 59Tocris Bioscience
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Compounds related to Exotropia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tunicamycin44 5910.7LMLN, DPAGT1

GO Terms for genes affiliated with Exotropia

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16Gene Ontology
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Cellular components related to Exotropia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.8PHOX2B, PHOX2A

Biological processes related to Exotropia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1noradrenergic neuron differentiationGO:0033579.9PHOX2B, PHOX2A
2dopaminergic neuron differentiationGO:0715429.8PHOX2B, PHOX2A
3sympathetic nervous system developmentGO:0484859.7PHOX2B, PHOX2A
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.8FOXC2, PHOX2A, PHOX2B, MC1R
5cell adhesionGO:0071558.6ACAN, LMLN, AMTN

Molecular functions related to Exotropia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.8PHOX2B, PHOX2A

Products for genes affiliated with Exotropia

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  • Antibodies
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Sources for Exotropia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet