MCID: EXT022
MIFTS: 36

Exotropia malady

Eye category

Summaries for Exotropia

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Exotropia (from Greek εξοτρὀπια, εξο \"exo\" meaning \"to exit\" or \"move out of\" and... more...

MalaCards: Exotropia, also known as divergent concomitant strabismus, is related to congenital nystagmus and hypotropia. An important gene associated with Exotropia is PHOX2A (paired-like homeobox 2a). The compound tunicamycin have been mentioned in the context of this disorder. Related mouse phenotype respiratory system.

Aliases & Classifications for Exotropia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

exotropia 8 10 61
divergent concomitant strabismus 8
exotropia, unspecified 8
unspecified exotropia 8
divergent strabismus 8
exotropia nos 8


External Ids:

Disease Ontology8 DOID:1143
NCIt40 C34601
ICD9CM27 378.1, 378.10
MeSH35 D005099
ICD1025 H50.1

Related Diseases for Exotropia

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Exotropia:



Diseases related to exotropia

Clinical Features for Exotropia

Drugs & Therapeutics for Exotropia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Exotropia

Drug clinical trials:

Search ClinicalTrials for Exotropia

Search NIH Clinical Center for Exotropia

Search CenterWatch for Exotropia

Genetic Tests for Exotropia

Anatomical Context for Exotropia

Animal Models for Exotropia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Exotropia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.0ACAN, PHOX2B, PHOX2A, FOXC2

Publications for Exotropia

Sources:
51PubMed
See all sources

Articles related to Exotropia:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Risk factors for consecutive exotropia. (24079667)
2013
2
Neurological exotropia: do we need to decrease surgical dosing? (23153655)
2013
3
Clinical characteristics of patients that experience different rates of exodrift after strabismus surgery for intermittent exotropia and the effect of the rate ofA exodrift on final ocular alignment. (23415036)
2013
4
Outcome of unilateral lateral rectus recession and medial rectus resection in primary exotropia. (23834953)
2013
5
Contralateral lateral rectus recession versus recess-resect for recurrent exotropia after unilateral recess-resect. (23536421)
2013
6
Corrrection of exotropia by implantable collamer lens. (24145567)
2013
7
Assessing divergence in children with intermittent exotropia. (22390326)
2012
8
Prognostic factors for recurrence after bilateral rectus recession procedure in patients with intermittent exotropia. (22441025)
2012
9
Surgery versus Active Monitoring in Intermittent Exotropia (SamExo): study protocol for a pilot randomised controlled trial. (23072556)
2012
10
Medulloblastoma presenting as consecutive esotropia after successful lateral rectus muscle recession for infantile exotropia. (22108367)
2011
11
Intermittent exotropia: facts, opinions, and unknowns. (21856876)
2011
12
Comparative study of unilateral and bilateral surgery in moderate exotropia. (19928700)
2010
13
Bilateral inferior rectus muscle dysgenesis with I>-pattern exotropia and blepharoptosis. (21171211)
2010
14
Long-term results of the surgical management of intermittent exotropia. (20736121)
2010
15
Refractive error changes in children with intermittent exotropia under overminus lens therapy. (20098893)
2009
16
Postoperative outcomes in children with intermittent exotropia from a population-based cohort. (18848478)
2009
17
Prevalence and sex differences of psychiatric disorders in young adults who had intermittent exotropia as children. (19506192)
2009
18
Surgical management for large hypertropia and exotropia after disinsertion of inferior rectus muscle. (19065984)
2008
19
Recession-resection combined with intraoperative botulinum toxin A chemodenervation for exotropia following subtotal ruptured of medial rectus muscle. (16628422)
2007
20
New tests of distance stereoacuity and their role in evaluating intermittent exotropia. (17241665)
2007
21
Consecutive exotropia following surgically corrected cyclic esotropia. (21149164)
2007
22
Unilateral recession-resection in children with exotropia of the convergence insufficiency type. (16327792)
2007
23
Accommodative ability in exotropia: predictive value of surgical success. (17446103)
2007
24
Unilateral lateral rectus muscle recession and medial rectus muscle resection with or without advancement for postoperative consecutive exotropia. (16814174)
2006
25
Survival analysis of 365 patients with exotropia after surgery. (16167074)
2006
26
Incidence and types of childhood exotropia: a population-based study. (15629828)
2005
27
Female predominance in intermittent exotropia. (16139014)
2005
28
Interventions for intermittent distance exotropia: review. (15359253)
2005
29
Sensory exotropia subsequent to senile cataract. (16358383)
2005
30
Long-term results of unilateral lateral rectus recession in intermittent exotropia. (14560836)
2003
31
Outcome of 5 mm resection of one medial rectus extraocular muscle for recurrent exotropia. (14521503)
2003
32
The association of ocular dominance and the preferred eye for fixation in intermittent exotropia: a guide to choosing the eye for unilateral surgery. (21149040)
2001
33
Diagnosis and treatment of exotropia with a high accommodation convergence-accommodation ratio. (10037567)
1999
34
Grand rounds #51: a case of consecutive exotropia after medial rectus recession for Duane syndrome. (9780416)
1998
35
Comparison between adjustable and non-adjustable hang-back muscle recession for concomitant exotropia. (9707843)
1998
36
The outcome of strabismus surgery in childhood exotropia. (7867818)
1994
37
Secondary exotropia: a retrospective analysis of matched cases. (8350225)
1993
38
Unilateral lateral rectus recessions in exotropia. (8351092)
1993
39
Exotropia as a sign of myasthenia gravis in dysthyroid ophthalmopathy. (8110684)
1993
40
Advancement of medial rectus muscle to the original insertion for consecutive exotropia. (8254445)
1993
41
Unilateral lateral rectus recession for the treatment of exotropia. (1570925)
1992
42
The use of part-time occlusion for early onset unilateral exotropia. (2709283)
1989
43
Hang-back lateral rectus recessions for exotropia. (2915310)
1989
44
Infantile exotropia in healthy children. (3222041)
1988
45
Role of occlusion in treatment of intermittent exotropia. (3506931)
1987
46
Orthoptic treatment of constant and intermittent exotropia. (749588)
1978
47
Changes in retinal correspondence following surgery for intermittent exotropia. (727222)
1978
48
Intermittent exotropia of the divergence excess type. (908827)
1977
49
Orthoptic management of intermittent exotropia. (4830088)
1974
50
V pattern exotropia. Electromyographic study of an unusual case. (4692263)
1973

Genetic Variations for Exotropia

Expression for genes affiliated with Exotropia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Exotropia

Search GEO for disease gene expression data for Exotropia.

Pathways for genes affiliated with Exotropia

Compounds for genes affiliated with Exotropia

Sources:
45Novoseek, 60Tocris Bioscience
See all sources

Compounds related to Exotropia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tunicamycin45 6010.7LMLN, DPAGT1

GO Terms for genes affiliated with Exotropia

Sources:
16Gene Ontology
See all sources

Cellular components related to Exotropia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.8PHOX2B, PHOX2A

Biological processes related to Exotropia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1noradrenergic neuron differentiationGO:0033579.9PHOX2B, PHOX2A
2dopaminergic neuron differentiationGO:0715429.8PHOX2B, PHOX2A
3sympathetic nervous system developmentGO:0484859.7PHOX2B, PHOX2A
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.8MC1R, PHOX2A, FOXC2, PHOX2B
5cell adhesionGO:0071558.6AMTN, LMLN, ACAN

Molecular functions related to Exotropia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.8PHOX2B, PHOX2A

Products for genes affiliated with Exotropia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Exotropia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet