MCID: EXT022
MIFTS: 39

Exotropia

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Exotropia

MalaCards integrated aliases for Exotropia:

Name: Exotropia 12 29 14 69
Divergent Concomitant Strabismus 12
Divergent Strabismus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1143
ICD10 33 H50.1 H50.10
ICD9CM 35 378.1 378.10
MeSH 42 D005099
NCIt 47 C34601
UMLS 69 C0015310

Summaries for Exotropia

MalaCards based summary : Exotropia, also known as divergent concomitant strabismus, is related to esotropia and alternating exotropia. An important gene associated with Exotropia is TUBB3 (Tubulin Beta 3 Class III). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and pineal.

Wikipedia : 72 Exotropia is a form of strabismus where the eyes are deviated outward. It is the opposite of esotropia... more...

Related Diseases for Exotropia

Diseases related to Exotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
id Related Disease Score Top Affiliating Genes
1 esotropia 31.8 CHN1 KIF21A TUBB3
2 alternating exotropia 12.0
3 monocular exotropia 11.8
4 mehes syndrome 11.0
5 lowry-maclean syndrome 10.8
6 mental retardation smith fineman myers type 10.8
7 miles-carpenter syndrome 10.8
8 coloboma of macula and skeletal anomalies 10.4 CHN1 TUBB3
9 secondary syphilis 10.4 ACAN TUBB3
10 peters-plus syndrome 10.3 PHOX2A TUBB3
11 monofixation syndrome 10.3 CHN1 TUBB3
12 cardiovascular cancer 10.3 PHOX2A TUBB3
13 leukemia 10.3 FBN1 TUBB3
14 autism susceptibility 17 10.3 KIF21A PHOX2A
15 strabismus 10.3
16 serous glue ear 10.2 CHN1 TNNI3K
17 mechanical strabismus 10.2 CHN1 TNNI3K
18 disuse amblyopia 10.2 CHN1 TUBB3
19 polydactyly, postaxial, with progressive myopia 10.1 CHN1 TUBB3
20 retinitis 10.0
21 ulceration of vulva 10.0 CHN1 KIF21A TUBB3
22 myopia 10.0
23 internuclear ophthalmoplegia 10.0
24 hemopericardium 10.0 PHOX2A PHOX2B
25 hypertropia 10.0
26 porencephaly 10.0 KIF21A PHOX2A TUBB3
27 mental retardation with spastic paraplegia 9.9 KIF21A PHOX2A TUBB3
28 sclerocornea 9.9 ACAN FBN1
29 pseudohypoparathyroidism ia 9.9 CHN1 KIF21A
30 hirschsprung disease 1 9.8 PHOX2A PHOX2B
31 accommodative esotropia 9.8
32 amblyopia 9.8
33 refractive error 9.7
34 duane retraction syndrome 9.7
35 keratoconus 9.7
36 hypotropia 9.7
37 ptosis 9.7
38 peripheral vertigo 9.6 CHN1 KIF21A PHOX2A TUBB3
39 abducens nerve disease 9.6 CHN1 KIF21A PHOX2A TUBB3
40 pleomorphic carcinoma 9.6 CHN1 KIF21A PHOX2A TUBB3
41 paget's disease of bone 9.6 CHN1 KIF21A PHOX2A TUBB3
42 astigmatism 9.6
43 cataract 9.6
44 cerebral palsy 9.6
45 diamond-blackfan anemia 9.6
46 abnormal retinal correspondence 9.6
47 myasthenia gravis 9.6
48 congenital toxoplasmosis 9.6
49 toxoplasmosis 9.6
50 retinitis pigmentosa 9.6

Graphical network of the top 20 diseases related to Exotropia:



Diseases related to Exotropia

Symptoms & Phenotypes for Exotropia

Drugs & Therapeutics for Exotropia

Drugs for Exotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 abobotulinumtoxinA Phase 4
3 Botulinum Toxins Phase 4
4 Botulinum Toxins, Type A Phase 4
5 Cholinergic Agents Phase 4
6 Neuromuscular Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 onabotulinumtoxinA Phase 4
9 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
10 Pharmaceutical Solutions Phase 4
11
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
12
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
13 Racepinephrine Approved Phase 2, Phase 3
14 Anesthetics Phase 2, Phase 3
15 Anesthetics, Local Phase 2, Phase 3
16 Central Nervous System Depressants Phase 2, Phase 3
17 Epinephryl borate Phase 2, Phase 3
18 Autonomic Agents
19 Mydriatics

Interventional clinical trials:

(show all 21)

id Name Status NCT ID Phase Drugs
1 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
2 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
3 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
4 Study of Non-surgical Treatment Versus Observation in Asian Children With Intermittent Exotropia Terminated NCT01267500 Phase 2
5 Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) in Two Recession Surgeries Unknown status NCT02450162
6 Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia With Convergence Weakness Completed NCT02131792
7 A Pilot Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Completed NCT02223650
8 Observation Versus Occlusion Therapy for Intermittent Exotropia Completed NCT01032330
9 A Novel Diagnostic Method for Exotropia Using Video-oculography Completed NCT03119311
10 Surgery and Convergence Insufficiency Intermittent Exotropia Completed NCT01435876
11 Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) Completed NCT02383381
12 Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus Surgery Completed NCT02699580
13 Assessing the Functional and Psychosocial Impact of Strabismus in Asian Children Using the AS-20 and IXTQ Questionnaires Completed NCT01608828
14 Study of Surgical Treatment Versus Observation in Children With Moderate Intermittent Exotropia Recruiting NCT02736526
15 Monitored Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Recruiting NCT02902887
16 Trial of Overminus Spectacle Therapy for Intermittent Exotropia Recruiting NCT02807350
17 Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Recruiting NCT02466659
18 Basic Intermittent Exotropia and Risk Factors for Postoperative Overcorrection and Under Correction Recruiting NCT03153423
19 Strabismus Surgery and Driving Ability Recruiting NCT02570555
20 Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia Active, not recruiting NCT01032603
21 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836

Search NIH Clinical Center for Exotropia

Genetic Tests for Exotropia

Genetic tests related to Exotropia:

id Genetic test Affiliating Genes
1 Exotropia 29

Anatomical Context for Exotropia

MalaCards organs/tissues related to Exotropia:

39
Eye, Testes, Pineal, Thyroid, Brain

Publications for Exotropia

Articles related to Exotropia:

(show top 50) (show all 624)
id Title Authors Year
1
Medial and Lateral Rectus Muscle Insertion Distance and Width in Esotropia and Exotropia Patients. ( 28632404 )
2017
2
Factors affecting residual exotropia after two muscle surgery for intermittent exotropia. ( 28730116 )
2017
3
Factors associated with atypical postoperative drift following surgery for consecutive exotropia. ( 28867397 )
2017
4
Capturing the Moment of Fusion Loss in Intermittent Exotropia. ( 28081943 )
2017
5
Relationship among clinical factors in childhood intermittent exotropia. ( 28666772 )
2017
6
Incomitance and Eye Dominance in Intermittent Exotropia. ( 28813578 )
2017
7
Comparison of Long-term Surgical Outcomes of Two-muscle Surgery in Basic-type Intermittent Exotropia: Bilateral versus Unilateral. ( 28682015 )
2017
8
Altered brain network centrality in patients with adult comitant exotropia strabismus: A resting-state fMRI study. ( 28679330 )
2017
9
The Riddle of Intermittent Exotropia. ( 28813579 )
2017
10
Proposing a new scoring system in intermittent exotropia: towards a better assessment of control. ( 28576201 )
2017
11
Predictors of surgical success in patients with intermittent exotropia. ( 28089744 )
2017
12
Congenital Double Elevator Palsy with Sensory Exotropia: A Unique Surgical Management. ( 28540016 )
2017
13
WITHDRAWN: Bilateral medial rectus resection for primary large angle exotropia. ( 28583469 )
2017
14
Everyday Exotropia: Learning from the Littlest. ( 28904215 )
2017
15
Comparison of outcomes of unilateral recession-resection as primary surgery and reoperation for intermittent Exotropia. ( 28679404 )
2017
16
Exotropia in a pediatric patient with rhabdomyolysis caused by an insect sting. ( 28643726 )
2017
17
Long-Term Surgical Outcomes of Early Surgery for Intermittent Exotropia in Children Less than 4 Years of Age. ( 28910161 )
2017
18
Effect of horizontal rectus surgery for the correction of intermittent exotropia on sub-A or sub-V pattern. ( 28628645 )
2017
19
Clinical Features and Surgical Outcome of Triad Exotropia. ( 28678305 )
2017
20
Long-term evaluation of two reoperation groups for intermittent exotropia. ( 28860030 )
2017
21
Far distance control scores for assessing intermittent exotropia. ( 28673866 )
2017
22
The Effect of Preoperative Occlusion Therapy on Long-term Outcome after Surgery for Early-onset Exotropia. ( 28534342 )
2017
23
Classifying medial rectus muscle attachment in consecutive exotropia. ( 27164430 )
2016
24
Does occlusion therapy improve control in intermittent exotropia? ( 28003783 )
2016
25
The Stabilization of Postoperative Exo-drift in Intermittent Exotropia after Surgical Treatment. ( 26865805 )
2016
26
Exploring the Divergence Range for Stereopsis Maintenance With a Computer-Simulated Troposcope in Patients With Intermittent Exotropia. ( 27571016 )
2016
27
Vertical Muscle Transposition with Augmentation for Treatment of Exotropia Caused by Iatrogenic Lost Medial Rectus Muscle. ( 27128148 )
2016
28
A Randomized Trial Evaluating Short-term Effectiveness of Overminus Lenses in Children 3 to 6 Years of Age with Intermittent Exotropia. ( 27506485 )
2016
29
Transient Exotropia after Open Reduction of a Naso-Ethmoidal-Orbital Fracture. ( 26848456 )
2016
30
Clinical risk factors for the development of consecutive exotropia: a comparative clinical study. ( 27366693 )
2016
31
Relationship between reading performance and saccadic disconjugacy in patients with convergence insufficiency type intermittent exotropia. ( 27112342 )
2016
32
Single Stage Surgical Outcomes for Large Angle Intermittent Exotropia. ( 26919493 )
2016
33
Type of the recurrent exotropia after bilateral rectus recession for intermittent exotropia. ( 27391365 )
2016
34
Adjustable surgical treatment of adult exotropia: postoperative target angles and surgical success. ( 27521663 )
2016
35
Clinical Characteristics and Surgical Outcomes in Patients With Intermittent Exotropia: A Large Sample Study in South China. ( 26844467 )
2016
36
Comment on "Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia with Convergence Insufficiency". ( 27057350 )
2016
37
Cyclic esotropia with development of a high accommodative convergenceA toA accommodation ratio after surgery for intermittent exotropia. ( 27628586 )
2016
38
Outcome of two-muscle surgery for large-angle intermittent exotropia in children. ( 27364773 )
2016
39
Comparison of long-term surgical outcomes between unilateral recession and unilateral recession-resection in small angle exotropia. ( 27066724 )
2016
40
Benign pineal cyst lined with normal choroid plexus mimicking tumour in a young girl with exotropia. ( 26811416 )
2016
41
Assessment of Cortical Dysfunction in Patients with Intermittent Exotropia: An fMRI Study. ( 27501391 )
2016
42
Large exotropia after retrobulbar anesthesia. ( 26953032 )
2016
43
A High Prevalence of Exotropia in Patients With Duane Retraction Syndrome in a Tertiary Eye Care Center in South India. ( 27977037 )
2016
44
Clinical exhibition of increased accommodative loads for binocular fusion in patients with basic intermittent exotropia. ( 27266700 )
2016
45
Rectus Extraocular Muscle Size and Pulley Location in Concomitant and Pattern Exotropia. ( 27448831 )
2016
46
Long-term Surgical Outcomes ofA Augmented Bilateral Lateral Rectus Recession in Children WithA Intermittent Exotropia. ( 27161987 )
2016
47
Surgical responses and outcomes of bilateral lateral rectus recession in exotropia with cerebral palsy. ( 27422358 )
2016
48
Classifying medial rectus muscle attachment in consecutive exotropia. ( 27663626 )
2016
49
Predictors of stereoacuity outcome in visually mature subjects with exotropia. ( 27510820 )
2016
50
The Incidence of Reoperation and Related Risk Factors Among Patients With Infantile Exotropia. ( 27783093 )
2016

Variations for Exotropia

Expression for Exotropia

Search GEO for disease gene expression data for Exotropia.

Pathways for Exotropia

GO Terms for Exotropia

Cellular components related to Exotropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 8.8 ACAN AMTN FBN1

Biological processes related to Exotropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.32 ACAN FBN1
2 dopaminergic neuron differentiation GO:0071542 9.26 PHOX2A PHOX2B
3 sympathetic nervous system development GO:0048485 9.16 PHOX2A PHOX2B
4 noradrenergic neuron differentiation GO:0003357 8.96 PHOX2A PHOX2B
5 parasympathetic nervous system development GO:0048486 8.62 PHOX2A PHOX2B

Molecular functions related to Exotropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.62 ACAN FBN1

Sources for Exotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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