MCID: EXT022
MIFTS: 39

Exotropia malady

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Exotropia

Aliases & Descriptions for Exotropia:

Name: Exotropia 12 29 14 69
Divergent Concomitant Strabismus 12
Divergent Strabismus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1143
ICD10 33 H50.1 H50.10
ICD9CM 35 378.1 378.10
MeSH 42 D005099
NCIt 47 C34601
UMLS 69 C0015310

Summaries for Exotropia

MalaCards based summary : Exotropia, also known as divergent concomitant strabismus, is related to alternating exotropia and monocular exotropia. An important gene associated with Exotropia is FBN1 (Fibrillin 1). The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid.

Wikipedia : 71 Exotropia is a form of strabismus where the eyes are deviated outward. It is the opposite of esotropia.... more...

Related Diseases for Exotropia

Diseases related to Exotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
id Related Disease Score Top Affiliating Genes
1 alternating exotropia 12.1
2 monocular exotropia 11.8
3 esotropia 11.2
4 miles-carpenter syndrome 10.8
5 strabismus 10.3
6 neurodegeneration due to cerebral folate transport deficiency 10.1 KIF21A PHOX2A
7 joubert syndrome 6 10.1 CHN1 KIF21A
8 lingual-facial-buccal dyskinesia 10.1 CHN1 KIF21A
9 amyotrophic neuralgia 10.1 CHN1 PHOX2A
10 pseudohypoparathyroidism ia 10.1 CHN1 KIF21A
11 deep keratitis 10.1 CHN1 ROBO3
12 uterine ligament serous adenocarcinoma 10.0 CHN1 PHOX2B
13 alopecia areata 10.0 CHN1 KIF21A PHOX2A
14 total third-nerve palsy 10.0 CHN1 KIF21A PHOX2A
15 urinary bladder villous adenoma 10.0 CHN1 KIF21A PHOX2A
16 pontocerebellar hypoplasia 10.0 CHN1 KIF21A PHOX2A
17 nerve fibre bundle defect 10.0 CHN1 KIF21A PHOX2A
18 retinitis 10.0
19 scapuloperoneal myopathy 10.0 ACAN FBN1
20 chronic infections, due to mbl deficiency 10.0 PHOX2A PHOX2B
21 physical disorder 10.0 ACAN ROBO3
22 myopia 10.0
23 internuclear ophthalmoplegia 10.0
24 sclerocornea 10.0 ACAN FBN1 ROBO3
25 hypertropia 10.0
26 febrile seizures, familial, 1 9.9 CHN1 KIF21A ROBO3
27 ulceration of vulva 9.9 CHN1 KIF21A ROBO3
28 mental retardation, autosomal dominant 7 9.8 CHN1 KIF21A PHOX2A ROBO3
29 chronic lacrimal gland enlargement 9.8 CHN1 KIF21A PHOX2A ROBO3
30 accommodative esotropia 9.8
31 amblyopia 9.8
32 refractive error 9.7
33 duane retraction syndrome 9.7
34 keratoconus 9.7
35 hypotropia 9.7
36 ptosis 9.7
37 choroiditis 9.6
38 eye disease 9.6
39 medulloblastoma 9.6
40 thyroiditis 9.6
41 attention deficit-hyperactivity disorder 9.6
42 accommodative spasm 9.6
43 chorioretinitis 9.6
44 crouzon syndrome 9.6
45 presbyopia 9.6
46 senile cataract 9.6
47 marfan syndrome 9.6
48 astigmatism 9.6
49 cataract 9.6
50 cerebral palsy 9.6

Graphical network of the top 20 diseases related to Exotropia:



Diseases related to Exotropia

Symptoms & Phenotypes for Exotropia

Drugs & Therapeutics for Exotropia

Drugs for Exotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4 51-84-3 187
2 Cholinergic Agents Phase 4
3 Neuromuscular Agents Phase 4
4 Neurotransmitter Agents Phase 4
5 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
6 Pharmaceutical Solutions Phase 4
7 abobotulinumtoxinA Phase 4
8 incobotulinumtoxinA Phase 4
9 onabotulinumtoxinA Phase 4
10 Botulinum Toxins Phase 4
11 Botulinum Toxins, Type A Phase 4
12
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
13
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
14 Anesthetics Phase 2, Phase 3
15 Anesthetics, Local Phase 2, Phase 3
16 Epinephryl borate Phase 2, Phase 3
17 Racepinephrine Phase 2, Phase 3
18 Central Nervous System Depressants Phase 2, Phase 3
19 Mydriatics
20 Autonomic Agents

Interventional clinical trials:

(show all 21)
id Name Status NCT ID Phase
1 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4
2 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
3 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3
4 Study of Non-surgical Treatment Versus Observation in Asian Children With Intermittent Exotropia Terminated NCT01267500 Phase 2
5 Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) in Two Recession Surgeries Unknown status NCT02450162
6 Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia With Convergence Weakness Completed NCT02131792
7 A Pilot Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia Completed NCT02223650
8 Observation Versus Occlusion Therapy for Intermittent Exotropia Completed NCT01032330
9 Surgery and Convergence Insufficiency Intermittent Exotropia Completed NCT01435876
10 Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) Completed NCT02383381
11 Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus Surgery Completed NCT02699580
12 Assessing the Functional and Psychosocial Impact of Strabismus in Asian Children Using the AS-20 and IXTQ Questionnaires Completed NCT01608828
13 Study of Surgical Treatment Versus Observation in Children With Moderate Intermittent Exotropia Recruiting NCT02736526
14 Monitored Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Recruiting NCT02902887
15 Trial of Overminus Spectacle Therapy for Intermittent Exotropia Recruiting NCT02807350
16 Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia Recruiting NCT02466659
17 Strabismus Surgery and Driving Ability Recruiting NCT02570555
18 Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia Active, not recruiting NCT01032603
19 A Novel Diagnostic Method for Exotropia Using Video-oculography Not yet recruiting NCT03119311
20 Basic Intermittent Exotropia and Risk Factors for Postoperative Overcorrection and Under Correction Not yet recruiting NCT03153423
21 The Effect of Light Deprivation on Visual Functions in Adult Amblyopes Not yet recruiting NCT02799836

Search NIH Clinical Center for Exotropia

Genetic Tests for Exotropia

Genetic tests related to Exotropia:

id Genetic test Affiliating Genes
1 Exotropia 29

Anatomical Context for Exotropia

MalaCards organs/tissues related to Exotropia:

39
Eye, Testes, Thyroid, Pineal

Publications for Exotropia

Articles related to Exotropia:

(show top 50) (show all 604)
id Title Authors Year
1
Capturing the Moment of Fusion Loss in Intermittent Exotropia. ( 28081943 )
2017
2
Predictors of surgical success in patients with intermittent exotropia. ( 28089744 )
2017
3
Type of the recurrent exotropia after bilateral rectus recession for intermittent exotropia. ( 27391365 )
2016
4
Predictors of stereoacuity outcome in visually mature subjects with exotropia. ( 27510820 )
2016
5
Abnormal medial rectus insertion presenting exotropia: a case report and review of the literature. ( 28003993 )
2016
6
Comment on "Exotropia Is the Main Pattern of Childhood Strabismus Surgery in the South of China: A Six-Year Clinical Review". ( 27523160 )
2016
7
Single Stage Surgical Outcomes for Large Angle Intermittent Exotropia. ( 26919493 )
2016
8
Comment on survival analysis following early surgical success in intermittent exotropia surgery. ( 27803877 )
2016
9
The Incidence of Reoperation and Related Risk Factors Among Patients With Infantile Exotropia. ( 27783093 )
2016
10
Exploring the Divergence Range for Stereopsis Maintenance With a Computer-Simulated Troposcope in Patients With Intermittent Exotropia. ( 27571016 )
2016
11
Clinical Characteristics and Surgical Outcomes in Patients With Intermittent Exotropia: A Large Sample Study in South China. ( 26844467 )
2016
12
Large exotropia after retrobulbar anesthesia. ( 26953032 )
2016
13
Relationship between reading performance and saccadic disconjugacy in patients with convergence insufficiency type intermittent exotropia. ( 27112342 )
2016
14
Classifying medial rectus muscle attachment in consecutive exotropia. ( 27164430 )
2016
15
Risk factors analysis of consecutive exotropia: Oblique muscle overaction may play an important role. ( 27977611 )
2016
16
Does occlusion therapy improve control in intermittent exotropia? ( 28003783 )
2016
17
Orbital surface coil imaging predicts surgical anatomy of medial rectus muscle in consecutive exotropia: a case report. ( 27208854 )
2016
18
Vertical Muscle Transposition with Augmentation for Treatment of Exotropia Caused by Iatrogenic Lost Medial Rectus Muscle. ( 27128148 )
2016
19
Postoperative Change in Ocular Torsion in Intermittent Exotropia: Relationship with Postoperative Surgical Outcomes. ( 27622574 )
2016
20
Post-operative strabismus control and motor alignment for basic intermittent exotropia. ( 27500110 )
2016
21
Cyclic esotropia with development of a high accommodative convergenceA toA accommodation ratio after surgery for intermittent exotropia. ( 27628586 )
2016
22
Symptoms in Children with Intermittent Exotropia and Their Impact on Health-Related Quality of Life. ( 27835070 )
2016
23
Comparison of long-term surgical outcomes between unilateral recession and unilateral recession-resection in small angle exotropia. ( 27066724 )
2016
24
Correlation between the Limbus-Insertion Distance of the Lateral Rectus Muscle and Lateral Rectus Recession Surgery in Intermittent Exotropia. ( 27463100 )
2016
25
Long-term Surgical Outcomes of Augmented Bilateral Lateral Rectus Recession in Children With Intermittent Exotropia. ( 27133014 )
2016
26
The Stabilization of Postoperative Exo-drift in Intermittent Exotropia after Surgical Treatment. ( 26865805 )
2016
27
A High Prevalence of Exotropia in Patients With Duane Retraction Syndrome in a Tertiary Eye Care Center in South India. ( 27977037 )
2016
28
Transient Exotropia after Open Reduction of a Naso-Ethmoidal-Orbital Fracture. ( 26848456 )
2016
29
A Randomized Trial Evaluating Short-term Effectiveness of Overminus Lenses in Children 3 to 6 Years of Age with Intermittent Exotropia. ( 27506485 )
2016
30
Comparison of Clinical Features and Long-term Surgical Outcomes in Infantile Constant and Intermittent Exotropia. ( 26848593 )
2016
31
Bilateral lateral rectus muscle recession for the convergence insufficiency type of intermittent exotropia. ( 27164428 )
2016
32
Outcome of two-muscle surgery for large-angle intermittent exotropia in children. ( 27364773 )
2016
33
Comparison of Postoperative Exodrift after First Unilateral and Second Contralateral Lateral Rectus Recession in Recurrent Exotropia. ( 26865803 )
2016
34
Assessment of Cortical Dysfunction in Patients with Intermittent Exotropia: An fMRI Study. ( 27501391 )
2016
35
Factors associated with surgical success in adult patients with exotropia. ( 27815187 )
2016
36
Rectus Extraocular Muscle Size and Pulley Location in Concomitant and Pattern Exotropia. ( 27448831 )
2016
37
Autogenous Fascia Lata Graft Fixation to Treat Exotropia Resulting From Iatrogenic Medial Rectus Transection. ( 27218813 )
2016
38
Benign pineal cyst lined with normal choroid plexus mimicking tumour in a young girl with exotropia. ( 26811416 )
2016
39
Classifying medial rectus muscle attachment in consecutive exotropia. ( 27663626 )
2016
40
Clinical exhibition of increased accommodative loads for binocular fusion in patients with basic intermittent exotropia. ( 27266700 )
2016
41
Intermittent exotropia with a positive Bielschowsky head-tilt test. ( 27215742 )
2016
42
Comment on "Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia with Convergence Insufficiency". ( 27057350 )
2016
43
Re: Brodsky etA al.: Intermittent exotropia andA accommodative esotropia: distinct disorders or two ends of a spectrum? (Ophthalmology 2015;122:1543-6). ( 26902571 )
2016
44
Postoperative Care and Follow-up Schedule for Intermittent Exotropia. ( 27428624 )
2016
45
Clinical risk factors for the development of consecutive exotropia: a comparative clinical study. ( 27366693 )
2016
46
Exotropia Is the Main Pattern of Childhood Strabismus Surgery in the South of China: A Six-Year Clinical Review. ( 27022476 )
2016
47
Surgical responses and outcomes of bilateral lateral rectus recession in exotropia with cerebral palsy. ( 27422358 )
2016
48
Long-term Surgical Outcomes ofA Augmented Bilateral Lateral Rectus Recession in Children WithA Intermittent Exotropia. ( 27161987 )
2016
49
Adjustable surgical treatment of adult exotropia: postoperative target angles and surgical success. ( 27521663 )
2016
50
Comparison of Lateral Rectus Muscle Re-recession and Medial Rectus Muscle Resection for Treatment of Postoperative Exotropia. ( 26514396 )
2015

Variations for Exotropia

Expression for Exotropia

Search GEO for disease gene expression data for Exotropia.

Pathways for Exotropia

GO Terms for Exotropia

Biological processes related to Exotropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.37 ACAN FBN1
2 negative regulation of neuron differentiation GO:0045665 9.32 EIF4ENIF1 PHOX2B
3 dopaminergic neuron differentiation GO:0071542 9.26 PHOX2A PHOX2B
4 sympathetic nervous system development GO:0048485 9.16 PHOX2A PHOX2B
5 noradrenergic neuron differentiation GO:0003357 8.96 PHOX2A PHOX2B
6 parasympathetic nervous system development GO:0048486 8.62 PHOX2A PHOX2B

Molecular functions related to Exotropia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.62 ACAN FBN1

Sources for Exotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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