MCID: EXT022
MIFTS: 40

Exotropia malady

Eye diseases category

Summaries for Exotropia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Exotropia (from Greek εξοτρὀπια, εξο \"exo\" meaning \"to exit\" or \"move out of\" and... more...

MalaCards: Exotropia, also known as divergent concomitant strabismus, is related to esotropia and congenital nystagmus. An important gene associated with Exotropia is PHOX2A (paired-like homeobox 2a). The compound tunicamycin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid, and related mouse phenotype respiratory system.

Aliases & Classifications for Exotropia

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

exotropia 8 10 60
divergent concomitant strabismus 8
exotropia, unspecified 8
unspecified exotropia 8
divergent strabismus 8
exotropia nos 8


External Ids:

Disease Ontology8 DOID:1143
NCIt39 C34601
ICD9CM27 378.1, 378.10
MeSH34 D005099
ICD1025 H50.1

Related Diseases for Exotropia

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Exotropia:



Diseases related to exotropia

Clinical Features for Exotropia

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Drugs & Therapeutics for Exotropia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Exotropia

Drug clinical trials:

Search ClinicalTrials for Exotropia

Search NIH Clinical Center for Exotropia

Search CenterWatch for Exotropia

Genetic Tests for Exotropia

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Anatomical Context for Exotropia

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Sources:
32MalaCards
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MalaCards organs/tissues related to Exotropia:

32
Eye, Testes, Thyroid

Animal Models for Exotropia or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Exotropia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.0ACAN, PHOX2B, PHOX2A, FOXC2

Publications for Exotropia

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Sources:
50PubMed
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Articles related to Exotropia:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Outcomes of surgery in children with early-onset exotropia. (23619215)
2013
2
Preoperative factors predicting the surgical response of bilateral lateral rectus recession surgery in patients with infantile exotropia. (23668308)
2013
3
Sensory exotropia associated with keratoconus and review of literature: strabismus and keratoconus. (24396962)
2013
4
Correlation between Worth Four Dot Test Results and Fusional Control in Intermittent Exotropia. (23275822)
2012
5
The many enigmas of intermittent exotropia. (22942159)
2012
6
Intermittent exotropia: when to observe and when to treat. (22153390)
2011
7
Exotropic drift and ocular alignment after surgical correction for intermittent exotropia. (20128548)
2010
8
Classification and misclassification of sensory monofixation in intermittent exotropia. (20381008)
2010
9
Acquired cyclic exotropia and hypotropia. (19541276)
2009
10
Alternating fixation and saccade behavior in nonhuman primates with alternating occlusion-induced exotropia. (19279316)
2009
11
Evaluation of distance and near stereoacuity and fusional vergence in intermittent exotropia. (19075419)
2009
12
Decreased postoperative drift in intermittent exotropia associated with A and V patterns. (19157935)
2009
13
Rectus pulley instability as a cause of Y-pattern exotropia revealed by magnetic resonance imaging. (19064865)
2008
14
The ultrastructural changes of tendon axonal profiles of medial rectus muscles according to duration in patients with intermittent exotropia. (18497836)
2008
15
Cavernous sinus meningioma presenting as intermittent exotropia in a 2-year-old girl. (17392878)
2007
16
Ocular motor behavior in macaques with surgical exotropia. (17928552)
2007
17
Interventions for intermittent exotropia. (16856017)
2006
18
Effects of unilateral lateral rectus recession according to the tendon width in intermittent exotropia. (16021187)
2006
19
Bilateral lateral rectus recession vs unilateral recess-resect procedure for exotropia with a dominant eye. (17011885)
2006
20
The surgical management of consecutive exotropia. (16814190)
2006
21
The surgical management of consecutive exotropia. (16814191)
2006
22
Surgical experiences with two-muscle surgery for the treatment of intermittent exotropia. (16814171)
2006
23
Cyclic exotropia associated with retinitis pigmentosa. (16550410)
2006
24
Homonymous hemianopia and exotropia: an important management issue. (16543929)
2006
25
The evaluation of office control in intermittent exotropia: a systematic approach. (21149078)
2003
26
Surgical results in large-angle exotropia. (11997802)
2002
27
Intermittent exotropia. (11705139)
2001
28
Timely surgery in intermittent and constant exotropia for superior sensory outcome. (11704057)
2001
29
Long-term outcome of uncomplicated infantile exotropia. (11753254)
2001
30
Intermittent exotropia: far distance target for surgical dosage. (9823372)
1998
31
The outcome of strabismus surgery in childhood exotropia. (8925940)
1996
32
Horizontal and vertical deviations after prism neutralization and diagnostic occlusion in intermittent exotropia. (21314546)
1994
33
Children with exotropia responsive to spectacle correction of hyperopia. (8328547)
1993
34
Medial rectus resection strategies for laterally incomitant intermittent exotropia. (3316591)
1987
35
Oculomotor biofeedback therapy for exotropia. (7102788)
1982
36
Intermittent exotropia: is surgery necessary? (7231875)
1981
37
Surgical results in intermittent exotropia. (7306871)
1981
38
Multiple regression analysis predictor models in exotropia surgery. (7446649)
1980
39
Simultaneous correction of blepharoptosis and exotropia in aberrant regeneration of the oculomotor nerve by strabismus surgery: a new, simplified ptosis correction for selected cases. (7454207)
1980
40
Monofixational intermittent exotropia. (758899)
1979
41
Monofixational intermittent exotropia. (464877)
1979
42
The management of overcorrections in exotropia. (1200472)
1975
43
Treatment of hyperopia associated with exotropia. (1078406)
1975
44
Visual therapy for constant exotropia with anomalous retinal correspondence-a case report. (4447112)
1974
45
Therapeutic uses of prisms in undercorrected intermittent exotropia. (5155079)
1971
46
Surgery of the inferior oblique muscles in V pattern exotropia. (5791499)
1969
47
RIGHT-ANGLE EXOTROPIA. (14233724)
1964
48
Orthoptic treatment of intermittent exotropia. (13998639)
1963
49
Preoperative treatment in intermittent exotropia. (13905926)
1962
50
Surgery for exotropia: fusional ability and choice of procedure. (13774207)
1960

Genetic Variations for Exotropia

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Expression for genes affiliated with Exotropia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Exotropia

Search GEO for disease gene expression data for Exotropia.

Pathways for genes affiliated with Exotropia

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Compounds for genes affiliated with Exotropia

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44Novoseek, 59Tocris Bioscience
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Compounds related to Exotropia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tunicamycin44 5910.7LMLN, DPAGT1

GO Terms for genes affiliated with Exotropia

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Sources:
16Gene Ontology
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Cellular components related to Exotropia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.8PHOX2B, PHOX2A

Biological processes related to Exotropia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1noradrenergic neuron differentiationGO:0033579.9PHOX2B, PHOX2A
2dopaminergic neuron differentiationGO:0715429.8PHOX2B, PHOX2A
3sympathetic nervous system developmentGO:0484859.7PHOX2B, PHOX2A
4positive regulation of transcription from RNA polymerase II promoterGO:0459448.8FOXC2, PHOX2A, PHOX2B, MC1R
5cell adhesionGO:0071558.6ACAN, LMLN, AMTN

Molecular functions related to Exotropia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.8PHOX2B, PHOX2A

Products for genes affiliated with Exotropia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Exotropia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet