MCID: EXT022
MIFTS: 39

Exotropia malady

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Exotropia

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Aliases & Descriptions for Exotropia:

Name: Exotropia 11 27 13 68
Divergent Concomitant Strabismus 11
 
Divergent Strabismus 11

Classifications:



External Ids:

Disease Ontology11 DOID:1143
ICD1030 H50.1, H50.10
ICD9CM32 378.1, 378.10
MeSH39 D005099
NCIt45 C34601

Summaries for Exotropia

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Wikipedia:71 Exotropia is a form of strabismus where the eyes are deviated outward. It is the opposite of esotropia.... more...

MalaCards based summary: Exotropia, also known as divergent concomitant strabismus, is related to accommodative esotropia and alternating exotropia. An important gene associated with Exotropia is FBN1 (Fibrillin 1). Affiliated tissues include eye, testes and pineal.

Related Diseases for Exotropia

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Diseases related to Exotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1accommodative esotropia29.9CHN1, KIF21A
2alternating exotropia12.1
3monocular exotropia11.8
4esotropia11.2
5miles-carpenter x-linked mental retardation syndrome10.8
6strabismus10.3
7disuse amblyopia10.1CHN1, PHOX2A
8retinitis10.0
9myopia10.0
10internuclear ophthalmoplegia10.0
11hypertropia10.0
12abducens nerve disease10.0CHN1, KIF21A, PHOX2A
13porencephaly9.9KIF21A, PHOX2A
14monofixation syndrome9.9CHN1, KIF21A, PHOX2A
15lymphoepithelioma-like carcinoma9.9CHN1, KIF21A, PHOX2A
16vaginal adenoma9.9CHN1, KIF21A, PHOX2A
17amblyopia9.8
18mental retardation with spastic paraplegia9.8KIF21A, PHOX2A
19total circumpapillary dystrophy of choroid9.8CHN1, ROBO3
20sclerosteosis9.7FBN1, ROBO3
21keratoconus9.7
22ptosis9.7
23refractive error9.7
24hypotropia9.7
25chromosomal disease9.6ACAN, FBN1, ROBO3
26meckel syndrome 39.6CHN1, KIF21A, ROBO3
27medulloblastoma9.6
28attention deficit-hyperactivity disorder9.6
29crouzon syndrome9.6
30marfan syndrome9.6
31cataract9.6
32cerebral palsy9.6
33diamond-blackfan anemia9.6
34myasthenia gravis9.6
35retinitis pigmentosa9.6
36cone dystrophy9.6
37tetanus9.6
38choroiditis9.6
39accommodative spasm9.6
40presbyopia9.6
41astigmatism9.6
42abnormal retinal correspondence9.6
43congenital toxoplasmosis9.6
44dermoid cyst9.6
45cerebritis9.6
46cavernous sinus meningioma9.6
47eye disease9.6
48thyroiditis9.6
49chorioretinitis9.6
50senile cataract9.6

Graphical network of the top 20 diseases related to Exotropia:



Diseases related to exotropia

Symptoms & Phenotypes for Exotropia

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Drugs & Therapeutics for Exotropia

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Drugs for Exotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholineapprovedPhase 477651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2Neurotransmitter AgentsPhase 417734
3onabotulinumtoxinAPhase 4626
4Pharmaceutical SolutionsPhase 47793
5Neuromuscular AgentsPhase 41129
6abobotulinumtoxinAPhase 4626
7Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 222776
8Botulinum ToxinsPhase 4669
9incobotulinumtoxinAPhase 4635
10Botulinum Toxins, Type APhase 4630
11Cholinergic AgentsPhase 43846
12
Epinephrineapproved, vet_approvedPhase 2, Phase 393351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
13
Bupivacaineapproved, investigationalPhase 2, Phase 311312180-92-9, 38396-39-32474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
(±)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
 
DepoBupivacaine
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
racemic bupivacaine
14RacepinephrinePhase 2, Phase 3933
15Central Nervous System DepressantsPhase 2, Phase 312806
16Epinephryl boratePhase 2, Phase 3933
17AnestheticsPhase 2, Phase 39001
18Autonomic AgentsPhase 39774
19MydriaticsPhase 3763
20Anesthetics, LocalPhase 2, Phase 33272

Interventional clinical trials:

(show all 19)
idNameStatusNCT IDPhase
1Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery AloneCompletedNCT01460355Phase 4
2A Pilot Clinical Trial of Overminus Spectacle Therapy for Intermittent ExotropiaCompletedNCT02223650Phase 2, Phase 3
3Orthoptic Changes Following Photorefractive KeratectomyCompletedNCT01279993Phase 3
4Trial of Overminus Spectacle Therapy for Intermittent ExotropiaRecruitingNCT02807350Phase 3
5Bupivacaine Injection of Eye Muscles to Treat StrabismusRecruitingNCT01616108Phase 2, Phase 3
6Study of Non-surgical Treatment Versus Observation in Asian Children With Intermittent ExotropiaTerminatedNCT01267500Phase 2
7Assessing the Functional and Psychosocial Impact of Strabismus in Asian Children Using the AS-20 and IXTQ QuestionnairesUnknown statusNCT01608828
8Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia With Convergence WeaknessCompletedNCT02131792
9Observation Versus Occlusion Therapy for Intermittent ExotropiaCompletedNCT01032330
10Surgery and Convergence Insufficiency Intermittent ExotropiaCompletedNCT01435876
11Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT)CompletedNCT02383381
12Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus SurgeryCompletedNCT02699580
13Study of Surgical Treatment Versus Observation in Children With Moderate Intermittent ExotropiaRecruitingNCT02736526
14Monitored Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent ExotropiaRecruitingNCT02902887
15Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent ExotropiaRecruitingNCT02466659
16Strabismus Surgery and Driving AbilityRecruitingNCT02570555
17Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent ExotropiaActive, not recruitingNCT01032603
18Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) in Two Recession SurgeriesNot yet recruitingNCT02450162
19The Effect of Light Deprivation on Visual Functions in Adult AmblyopesNot yet recruitingNCT02799836

Search NIH Clinical Center for Exotropia

Genetic Tests for Exotropia

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Genetic tests related to Exotropia:

id Genetic test Affiliating Genes
1 Exotropia27

Anatomical Context for Exotropia

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MalaCards organs/tissues related to Exotropia:

36
Eye, Testes, Pineal, Thyroid

Publications for Exotropia

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Articles related to Exotropia:

(show top 50)    (show all 604)
idTitleAuthorsYear
1
Predictors of surgical success in patients with intermittent exotropia. (28089744)
2017
2
Capturing the Moment of Fusion Loss in Intermittent Exotropia. (28081943)
2017
3
Abnormal medial rectus insertion presenting exotropia: a case report and review of the literature. (28003993)
2016
4
Clinical risk factors for the development of consecutive exotropia: a comparative clinical study. (27366693)
2016
5
The Stabilization of Postoperative Exo-drift in Intermittent Exotropia after Surgical Treatment. (26865805)
2016
6
Cyclic esotropia with development of a high accommodative convergenceA toA accommodation ratio after surgery for intermittent exotropia. (27628586)
2016
7
Re: Brodsky etA al.: Intermittent exotropia andA accommodative esotropia: distinct disorders or two ends of a spectrum? (Ophthalmology 2015;122:1543-6). (26902571)
2016
8
The Incidence of Reoperation and Related Risk Factors Among Patients With Infantile Exotropia. (27783093)
2016
9
Transient Exotropia after Open Reduction of a Naso-Ethmoidal-Orbital Fracture. (26848456)
2016
10
Assessment of Cortical Dysfunction in Patients with Intermittent Exotropia: An fMRI Study. (27501391)
2016
11
Post-operative strabismus control and motor alignment for basic intermittent exotropia. (27500110)
2016
12
Predictors of stereoacuity outcome in visually mature subjects with exotropia. (27510820)
2016
13
Rectus Extraocular Muscle Size and Pulley Location in Concomitant and Pattern Exotropia. (27448831)
2016
14
Vertical Muscle Transposition with Augmentation for Treatment of Exotropia Caused by Iatrogenic Lost Medial Rectus Muscle. (27128148)
2016
15
A High Prevalence of Exotropia in Patients With Duane Retraction Syndrome in a Tertiary Eye Care Center in South India. (27977037)
2016
16
Benign pineal cyst lined with normal choroid plexus mimicking tumour in a young girl with exotropia. (26811416)
2016
17
Classifying medial rectus muscle attachment in consecutive exotropia. (27663626)
2016
18
Adjustable surgical treatment of adult exotropia: postoperative target angles and surgical success. (27521663)
2016
19
Comparison of long-term surgical outcomes between unilateral recession and unilateral recession-resection in small angle exotropia. (27066724)
2016
20
Outcome of two-muscle surgery for large-angle intermittent exotropia in children. (27364773)
2016
21
Surgical responses and outcomes of bilateral lateral rectus recession in exotropia with cerebral palsy. (27422358)
2016
22
Bilateral lateral rectus muscle recession for the convergence insufficiency type of intermittent exotropia. (27164428)
2016
23
Comparison of Clinical Features and Long-term Surgical Outcomes in Infantile Constant and Intermittent Exotropia. (26848593)
2016
24
Comparison of Postoperative Exodrift after First Unilateral and Second Contralateral Lateral Rectus Recession in Recurrent Exotropia. (26865803)
2016
25
Large exotropia after retrobulbar anesthesia. (26953032)
2016
26
Clinical exhibition of increased accommodative loads for binocular fusion in patients with basic intermittent exotropia. (27266700)
2016
27
Classifying medial rectus muscle attachment in consecutive exotropia. (27164430)
2016
28
Risk factors analysis of consecutive exotropia: Oblique muscle overaction may play an important role. (27977611)
2016
29
Comment on survival analysis following early surgical success in intermittent exotropia surgery. (27803877)
2016
30
Exploring the Divergence Range for Stereopsis Maintenance With a Computer-Simulated Troposcope in Patients With Intermittent Exotropia. (27571016)
2016
31
Postoperative Care and Follow-up Schedule for Intermittent Exotropia. (27428624)
2016
32
Long-term Surgical Outcomes of Augmented Bilateral Lateral Rectus Recession in Children With Intermittent Exotropia. (27133014)
2016
33
Comment on "Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia with Convergence Insufficiency". (27057350)
2016
34
Exotropia Is the Main Pattern of Childhood Strabismus Surgery in the South of China: A Six-Year Clinical Review. (27022476)
2016
35
A Randomized Trial Evaluating Short-term Effectiveness of Overminus Lenses in Children 3 to 6 Years of Age with Intermittent Exotropia. (27506485)
2016
36
Does occlusion therapy improve control in intermittent exotropia? (28003783)
2016
37
Long-term Surgical Outcomes ofA Augmented Bilateral Lateral Rectus Recession in Children WithA Intermittent Exotropia. (27161987)
2016
38
Relationship between reading performance and saccadic disconjugacy in patients with convergence insufficiency type intermittent exotropia. (27112342)
2016
39
Factors associated with surgical success in adult patients with exotropia. (27815187)
2016
40
Clinical Characteristics and Surgical Outcomes in Patients With Intermittent Exotropia: A Large Sample Study in South China. (26844467)
2016
41
Postoperative Change in Ocular Torsion in Intermittent Exotropia: Relationship with Postoperative Surgical Outcomes. (27622574)
2016
42
Single Stage Surgical Outcomes for Large Angle Intermittent Exotropia. (26919493)
2016
43
Correlation between the Limbus-Insertion Distance of the Lateral Rectus Muscle and Lateral Rectus Recession Surgery in Intermittent Exotropia. (27463100)
2016
44
Orbital surface coil imaging predicts surgical anatomy of medial rectus muscle in consecutive exotropia: a case report. (27208854)
2016
45
Symptoms in Children with Intermittent Exotropia and Their Impact on Health-Related Quality of Life. (27835070)
2016
46
Type of the recurrent exotropia after bilateral rectus recession for intermittent exotropia. (27391365)
2016
47
Autogenous Fascia Lata Graft Fixation to Treat Exotropia Resulting From Iatrogenic Medial Rectus Transection. (27218813)
2016
48
Intermittent exotropia with a positive Bielschowsky head-tilt test. (27215742)
2016
49
Comment on "Exotropia Is the Main Pattern of Childhood Strabismus Surgery in the South of China: A Six-Year Clinical Review". (27523160)
2016
50
Bilateral superior rectus transposition for congenital exotropia associated withA anomalous medial rectusA muscles. (26486030)
2015

Variations for Exotropia

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Expression for genes affiliated with Exotropia

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Search GEO for disease gene expression data for Exotropia.

Pathways for genes affiliated with Exotropia

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GO Terms for genes affiliated with Exotropia

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Biological processes related to Exotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:002261710.3ACAN, FBN1
2dopaminergic neuron differentiationGO:007154210.2PHOX2A, PHOX2B
3noradrenergic neuron differentiationGO:000335710.0PHOX2A, PHOX2B
4parasympathetic nervous system developmentGO:004848610.0PHOX2A, PHOX2B
5negative regulation of neuron differentiationGO:00456659.9EIF4ENIF1, PHOX2B
6sympathetic nervous system developmentGO:00484859.7PHOX2A, PHOX2B

Molecular functions related to Exotropia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:00052019.8ACAN, FBN1

Sources for Exotropia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet