MCID: EXS007
MIFTS: 31

Exstrophy of the Bladder malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases

Aliases & Classifications for Exstrophy of the Bladder

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Aliases & Descriptions for Exstrophy of the Bladder:

Name: Exstrophy of the Bladder 46
Exstrophy of Bladder 23 25
 
Bladder Exstrophy 46

Classifications:



Summaries for Exstrophy of the Bladder

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MalaCards based summary: Exstrophy of the Bladder, also known as exstrophy of bladder, is related to exstrophy of bladder bladder exstrophy and epispadias complex, included and adenocarcinoma. An important gene associated with Exstrophy of the Bladder is WNT3 (Wnt Family Member 3), and among its related pathways are Wnt signaling pathway (KEGG) and HTLV-I infection. Affiliated tissues include kidney, colon and testes.

Related Diseases for Exstrophy of the Bladder

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Diseases related to Exstrophy of the Bladder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1exstrophy of bladder bladder exstrophy and epispadias complex, included11.5
2adenocarcinoma10.3
3abdominal wall defect10.2
4imperforate anus10.1
5epispadias10.0
6oeis complex9.8
7omphalocele9.8
8trigonitis9.8
9down syndrome9.8
10colon adenocarcinoma9.8
11penile agenesis9.8
12linear lichen planus8.9AMY2A, WNT3, WNT9B

Graphical network of diseases related to Exstrophy of the Bladder:



Diseases related to exstrophy of the bladder

Symptoms for Exstrophy of the Bladder

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Drugs & Therapeutics for Exstrophy of the Bladder

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Transurethral Myoblast Injection for Urinary Incontinence in Children With Bladder ExstrophyRecruitingNCT02075216Phase 1, Phase 2
2Muscle Derived Cell Therapy for Bladder Exstrophy Epispadias Induced IncontinenceNot yet recruitingNCT01011777Phase 1
3Biomechanical Assessment of Level Gait in Patient's Status Post Bladder ExstrophyRecruitingNCT00863070
4Navigation of the Pelvic Floor in Bladder Exstrophy Using Pre-operative MRIEnrolling by invitationNCT01878500
5Kidney Function in Patients With Bladder ExstrophyNot yet recruitingNCT02192801
6Bladder Exstrophy (FIVES FertIlity Vesical Exstrophy Sexuality)Not yet recruitingNCT02759705

Search NIH Clinical Center for Exstrophy of the Bladder

Genetic Tests for Exstrophy of the Bladder

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Genetic tests related to Exstrophy of the Bladder:

id Genetic test Affiliating Genes
1 Exstrophy of the Bladder25
2 Exstrophy of Bladder23

Anatomical Context for Exstrophy of the Bladder

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MalaCards organs/tissues related to Exstrophy of the Bladder:

34
Kidney, Colon, Testes, Testis, Uterus, Bone

Animal Models for Exstrophy of the Bladder or affiliated genes

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Publications for Exstrophy of the Bladder

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Articles related to Exstrophy of the Bladder:

(show top 50)    (show all 153)
idTitleAuthorsYear
1
Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder. (24852367)
2014
2
Prenatal findings of omphalocele-exstrophy of the bladder-imperforate anus-spinal defects (OEIS) complex. (22925220)
2012
3
Duplicate exstrophy of the bladder. (10235339)
1999
4
Re: Secondary reconstruction of abdominal wall defects associated with exstrophy of the bladder. (7793798)
1995
5
Re: Secondary reconstruction of abdominal wall defects associated with exstrophy of the bladder. (7857058)
1994
6
Carcinoma of the colon after ureterosigmoidostomy and trigonosigmoidostomy for exstrophy of the bladder. (8276563)
1993
7
Exstrophy of the bladder: primary closure after iliac osteotomies without external or internal fixation. (1732612)
1992
8
Seven years' experience of ureterosigmoidostomy in surgically failed exstrophy of the bladder. (2286760)
1990
9
Adenocarcinoma development in the trigone 34 years after trigonocolonic urinary diversion for exstrophy of the bladder. (2398574)
1990
10
Incomplete exstrophy of the bladder. (3208027)
1988
11
Exstrophy of the bladder: diagnosis on a bone scan. (6457721)
1981
12
Late development of colonic adenocarcinoma 49 years after ureterosigmoidostomy for exstrophy of the bladder. (7420602)
1980
13
Exstrophy of the bladder: long-term results of bilateral posterior iliac osteotomies and two-stage anatomic repair. (7418304)
1980
14
Duplicate exstrophy of the bladder. (6445705)
1980
15
Exstrophy of the bladder: treatment by trigonosigmoidostomy--long-term results. (754857)
1978
16
Exstrophy of the bladder. (847114)
1977
17
Adult exstrophy of the bladder with adenocarcinoma. (894055)
1977
18
Reconstruction of the external genitalia in exstrophy of the bladder: preliminary communication. (4275413)
1974
19
Exstrophy of the bladder and associated anomalies. (4470888)
1974
20
An anomaly of the external genitalia in female patients with exstrophy of the bladder. (4745175)
1973
21
Exstrophy of the bladder. (4939306)
1971
22
A new concept concerning treatment of exstrophy of the bladder: 20 years later. (5137786)
1971
23
Lysergic acid diethylamide (LSD) and exstrophy of the bladder. (5486624)
1970
24
Functional closure of typical exstrophy of the bladder. (4246637)
1970
25
Bilateral iliac osteotomy. The first stage in repair of exstrophy of the bladder. (5414713)
1970
26
Exstrophy of the bladder. (5371091)
1969
27
Primary closure and iliac osteotomy in the treatment of exstrophy of the bladder. A case report. (5783814)
1969
28
Pregnancy and delivery following bilateral ureteral transplantation to the bowel for exstrophy of the bladder. (6044593)
1967
29
Innominate osteotomy in reconstructive surgery for exstrophy of the bladder. (6080306)
1967
30
Care of the infant with exstrophy of the bladder. (20737782)
1967
31
The congenitally malformed. VII. Exstrophy of the bladder and cloacal exstrophy. (5930948)
1966
32
A modified technique for pelvic reconstruction in the treatment of exstrophy of the bladder. (5911494)
1966
33
EXSTROPHY OF THE BLADDER. (14115716)
1964
34
New approaches to the management of exstrophy of the bladder. (13963599)
1963
35
SURGICAL TREATMENT OF THE EXSTROPHY OF THE BLADDER AND OF THE ASSOCIATED PATHOLOGICAL CHANGES. (14119143)
1963
36
Iliac osteoclast: a new instrument which facilitates operation for exstrophy of the bladder. (14481126)
1961
37
Attempted surgical correction of exstrophy of the bladder. (14498490)
1961
38
An improved surgical procedure for exstrophy of the bladder. A preliminary report. (13737625)
1960
39
Results of surgical reconstruction in exstrophy of the bladder. (13605406)
1959
40
Ten to 25-year follow-up studies in four cases of exstrophy of the bladder. (13567815)
1958
41
A method of lengthening and repairing the penis in exstrophy of the bladder. (13514873)
1958
42
Changing trends in the management of exstrophy of the bladder. (13442880)
1957
43
A method of closure of the abdominal wall defect in exstrophy of the bladder. (13327152)
1956
44
A simplified technique for cystectomy and repair of the abdominal defect in exstrophy of the bladder. (13380893)
1956
45
A new concept concerning treatment of exstrophy of the bladder. (14928330)
1952
46
Exstrophy of the bladder. (14807070)
1951
47
Treatment of exstrophy of the bladder. (15409937)
1950
48
Exstrophy of the bladder with pyelographic follow-up. (18858055)
1948
49
Exstrophy of the bladder with imperforate anus, absence of the greater part of the small and large intestines, continuity of the duodenum with the colon, absence of the left testis, epididymis and cord, and enormous hydroureter. (19970406)
1938
50
Exstrophy of the Bladder. (18733676)
1905

Variations for Exstrophy of the Bladder

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Expression for genes affiliated with Exstrophy of the Bladder

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Search GEO for disease gene expression data for Exstrophy of the Bladder.

Pathways for genes affiliated with Exstrophy of the Bladder

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Pathways related to Exstrophy of the Bladder according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.0WNT3, WNT9B
29.0WNT3, WNT9B
3
Show member pathways
9.0WNT3, WNT9B
4
Show member pathways
9.0WNT3, WNT9B
59.0WNT3, WNT9B
69.0WNT3, WNT9B
7
Show member pathways
9.0WNT3, WNT9B
8
Show member pathways
9.0WNT3, WNT9B
99.0WNT3, WNT9B
109.0WNT3, WNT9B
11
Show member pathways
9.0WNT3, WNT9B
129.0WNT3, WNT9B
139.0WNT3, WNT9B
149.0WNT3, WNT9B
15
Show member pathways
9.0WNT3, WNT9B

GO Terms for genes affiliated with Exstrophy of the Bladder

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Cellular components related to Exstrophy of the Bladder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055789.2WNT3, WNT9B
2extracellular spaceGO:00056158.5AMY2A, WNT3, WNT9B
3extracellular regionGO:00055768.2AMY2A, WNT3, WNT9B

Biological processes related to Exstrophy of the Bladder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell fate commitmentGO:00451659.5WNT3, WNT9B
2cellular response to retinoic acidGO:00713009.3WNT3, WNT9B
3canonical Wnt signaling pathwayGO:00600709.1WNT3, WNT9B
4neuron differentiationGO:00301829.0WNT3, WNT9B
5Wnt signaling pathwayGO:00160558.7WNT3, WNT9B

Molecular functions related to Exstrophy of the Bladder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1frizzled bindingGO:00051099.0WNT3, WNT9B

Sources for Exstrophy of the Bladder

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet