MCID: EXT010
MIFTS: 52

Extramedullary Plasmacytoma malady

Cancer category

Summaries for Extramedullary Plasmacytoma

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33MalaCards
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MalaCards: Extramedullary Plasmacytoma, also known as plasmacytoma, extramedullary, is related to amyloidosis and squamous cell carcinoma. An important gene associated with Extramedullary Plasmacytoma is ZNF347 (zinc finger protein 347), and among its related pathways are Glioma and Downstream signaling in naive CD8+ T cells. The compounds cycloheximide and butyrate have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and tongue, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Extramedullary Plasmacytoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

extramedullary plasmacytoma 8 61
plasmacytoma, extramedullary 8
extraosseous plasmacytoma 8


External Ids:

Disease Ontology8 DOID:3720
NCIt40 C4002
ICD1025 C90.2

Related Diseases for Extramedullary Plasmacytoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Extramedullary Plasmacytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis30.6B2M, IGKC
2squamous cell carcinoma30.4CDKN1A, BCL2, IFI27, VEGFA, CCND1, BCL2L1
3macroglobulinemia30.2B2M
4kaposi's sarcoma30.2IL6
5follicular lymphoma30.2BCL2, CCND1, BCL2L1
6adenoma30.2BCL2, IFI27, CCND1, CDKN1A
7adenocarcinoma30.1BCL2, BCL2L1, CDKN1A, IFI27, CCND1, VEGFA
8bladder carcinoma30.1VEGFA, CDKN1A, IFI27, CCND1, IL2, BCL2L1
9obstructive jaundice10.3
10intussusception10.3
11thyroiditis10.3
12anaplastic plasmacytoma10.3
13extramedullary soft tissue plasmacytoma10.3
14cardiac tamponade10.2
15extrahepatic cholestasis10.2
16plasmablastic lymphoma10.2
17tolosa-hunt syndrome10.1
18colon lymphoma10.1
19papillary carcinoma10.1
20thyroid lymphoma10.1
21orbital cellulitis10.1
22multinodular goiter10.1
23cellulitis10.1
24exophthalmos10.1
25sialadenitis10.1
26ulcerative colitis10.1
27hodgkin's granuloma10.1
28solitary osseous plasmacytoma10.1
29bladder transitional cell carcinoma10.1
30transitional cell carcinoma10.1
31amyopathic dermatomyositis10.1
32angiofollicular lymph hyperplasia10.1
33heart tumor10.1
34plasma cell leukemia10.1
35waldenstrom macroglobulinemia10.1
36oral squamous cell carcinoma10.1
37soft tissue sarcoma10.1
38back pain10.1
39dysphagia10.1
40cervical intraepithelial neoplasia10.0IFI27
41pituitary adenoma10.0IFI27
42anaplastic large cell lymphoma10.0IL2RB
43ductal carcinoma in situ10.0CCND1
44esophageal cancer10.0CCND1
45smooth muscle tumor10.0IFI27
46polymyalgia rheumatica10.0IL2RB
47gastrointestinal stromal tumor10.0IFI27
48hepatitis10.0IL2RB
49pituitary tumors10.0IFI27
50macroglobulinemia, waldenstrom, somatic10.0CCND1

Graphical network of the top 20 diseases related to Extramedullary Plasmacytoma:



Diseases related to extramedullary plasmacytoma

Clinical Features for Extramedullary Plasmacytoma

Drugs & Therapeutics for Extramedullary Plasmacytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Extramedullary Plasmacytoma

Drug clinical trials:

Search ClinicalTrials for Extramedullary Plasmacytoma

Search NIH Clinical Center for Extramedullary Plasmacytoma

Search CenterWatch for Extramedullary Plasmacytoma

Genetic Tests for Extramedullary Plasmacytoma

Anatomical Context for Extramedullary Plasmacytoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Extramedullary Plasmacytoma:

33
Skin, Liver, Tongue, Spinal cord, Kidney, Lymph node, Lung, Bone marrow, Heart, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Testis, Cervix, Tonsil, T cells, B cells, Trachea, Pancreatic islet, Pituitary

Animal Models for Extramedullary Plasmacytoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Extramedullary Plasmacytoma

Sources:
51PubMed
See all sources

Articles related to Extramedullary Plasmacytoma:

(show top 50)    (show all 459)
idTitleAuthorsYear
1
Extramedullary plasmacytoma of maxillary sinus. (23348350)
2013
2
Multiple extramedullary plasmacytoma with lytic bony lesions: a rare case report. (23476660)
2013
3
Primary solitary extramedullary plasmacytoma involving the true vocal cords in a pregnant woman. (23549014)
2013
4
Solitary Extramedullary Plasmacytoma of the Parotid Gland Imaged With 18F-FDG PET/CT. (24152625)
2013
5
Plasmacytoma of the nasolacrimal duct simulating dacryocystitis: an uncommon presentation for extramedullary relapse of multiple myeloma. (22666199)
2012
6
An unusual occurrence of solitary extramedullary plasmacytoma in the conjunctiva. (22844362)
2012
7
Extramedullary plasmacytoma of the true vocal fold. (22930090)
2012
8
Extramedullary plasmacytoma imitating neoplasm of the gallbladder fossa after cholecystectomy. (22816242)
2012
9
Plasmablastic extramedullary plasmacytoma associated with Epstein-Barr virus arising in an immunocompetent patient with multiple myeloma. (22041368)
2011
10
Extramedullary plasmacytoma of the tongue base. (21234132)
2010
11
Cervical lymph node metastasis of extramedullary plasmacytoma of the tonsil presenting with granulomatous lymphadenitis in fine needle aspiration cytology. (20968166)
2010
12
Primary antral duodenal extramedullary plasmacytoma presenting with melena. (19286477)
2010
13
Extramedullary plasmacytoma are characterized by a 'myeloma-like' immunophenotype and genotype and occult bone marrow involvement. (20880115)
2010
14
Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004. (19016727)
2009
15
Solitary extramedullary plasmacytoma of the vocal cord in an adolescent. (19858382)
2009
16
Extramedullary plasmacytoma of the larynx in an adolescent: a case report and review of the literature. (19224468)
2009
17
Incidental detection of concurrent extramedullary plasmacytoma and amyloidoma of the nasopharynx on [18F]fluorodeoxyglucose positron emission tomography/computed tomography. (19001338)
2008
18
Extramedullary plasmacytoma presented as a non-functional invasive pituitary macro-adenoma. (18317687)
2008
19
Extramedullary plasmacytoma of the nasal sinus cavities. (17162133)
2007
20
Extramedullary plasmacytoma of the larynx. (16406428)
2006
21
Radiotherapy for solitary extramedullary plasmacytoma in the head-and-neck region: A dose greater than 45 Gy to the target volume improves the local control. (16343803)
2006
22
Extramedullary plasmacytoma arising from the nasal septum. (16381136)
2005
23
Biclonal extramedullary plasmacytoma arising in the peritoneal cavity: report of a case. (15052459)
2004
24
A case of Crow-Fukase syndrome with extramedullary plasmacytoma: marked clinical deterioration following a biopsy to plasmacytoma]. (12884826)
2003
25
Extramedullary plasmacytoma invading the bladder: case report and review of the literature. (14693267)
2003
26
Localized amyloidosis and extramedullary plasmacytoma involving the larynx of a child. (11172308)
2001
27
Extramedullary primary cutaneous plasmacytoma. Description of a case] . (11072738)
2000
28
Solitary extramedullary plasmacytoma of the nasopharynx. (11003081)
2000
29
Extramedullary plasmacytoma: a localized or systemic disease? (9441581)
1998
30
Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases. (9062417)
1997
31
Multiple myeloma presenting as extramedullary plasmacytoma of the thyroid, advanced grade II-III plasmablastic type. (7644950)
1995
32
Inadequately irradiated solitary extramedullary plasmacytoma of the orbit requiring exenteration. (8540559)
1995
33
Fine-needle aspiration of pancreatic extramedullary plasmacytoma: possible confusion with islet cell tumor. (7924813)
1994
34
Laser treatment of endobronchial extramedullary plasmacytoma. (7924514)
1994
35
Primary extramedullary plasmacytoma in the middle ear: differential diagnosis and management. (7989836)
1994
36
Extramedullary plasmacytoma of the thyroid, associated with follicular colonization and stromal deposition of polytypic immunoglobulins and major histocompatibility antigens. Possible categorization in MALT lymphoma. (1476063)
1992
37
Case report: extramedullary plasmacytoma of the larynx. (1394084)
1992
38
Gastric extramedullary plasmacytoma in a dog. (1612985)
1992
39
Solitary conjunctival extramedullary plasmacytoma. (2350120)
1990
40
Extramedullary plasmacytoma of the testicle. Sonographic appearance and ultrasonically guided biopsy. (2198076)
1990
41
Pericarditis and pleuritis caused by extramedullary plasmacytoma. (2077463)
1990
42
Evolution of extramedullary plasmacytoma in a patient with primary SjAPgren's syndrome. (2302263)
1990
43
Tc-99m DTPA uptake in extramedullary plasmacytoma of the retroperitoneum. (3073030)
1988
44
Extramedullary plasmacytoma with crystal inclusions arising from the palatal tonsil. (6313887)
1983
45
Radiotherapy of extramedullary plasmacytoma of the head and neck. (6783361)
1981
46
Primary extramedullary plasmacytoma of the omentum associated with recurrent adenocarcinoma of the colon: first case report. (7409797)
1980
47
Cervical lymph node metastasis as the first manifestation of localized extramedullary plasmacytoma. (991083)
1976
48
Solitary extramedullary plasmacytoma of the head and neck. (1198778)
1975
49
Extramedullary plasmacytoma of the submaxillary gland. (5774664)
1969
50
Amyloidosis associated with an extramedullary plasmacytoma. (5777528)
1969

Genetic Variations for Extramedullary Plasmacytoma

Expression for genes affiliated with Extramedullary Plasmacytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Extramedullary Plasmacytoma

Search GEO for disease gene expression data for Extramedullary Plasmacytoma.

Pathways for genes affiliated with Extramedullary Plasmacytoma

Sources:
30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 52QIAGEN, 53R&D Systems, 56SinoBiological
See all sources

Pathways related to Extramedullary Plasmacytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2CDKN1A
29.7B2M, IL2RB, IL2
3
Hide members
9.7IL2, IL2RB, B2M
49.6BCL2, CDKN1A, CCND1
59.6BCL2, CDKN1A, CCND1
6
Hide members
9.6IL2RB, IL2, BCL2
7
Transcription Androgen Receptor nuclear signaling
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9.6IL6, CDKN1A, CCND1
8
Hide members
9.6IL2, IL6, IL2RB
99.5IL2, IL6, CCND1
109.5CDKN1A, IL6, IL2
119.5CCND1, IL6, BCL2
129.5CDKN1A, IL6, BCL2
13
Transcription P53 signaling pathway
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9.5VEGFA, CDKN1A, BCL2
14
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.4CCND1, VEGFA, IL6
15
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9.4CCND1, IL2RB, IL2, BCL2
169.3BCL2L1, BCL2
17
Hide members
9.3BCL2, BCL2L1
18
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9.3BCL2, BCL2L1
19
Hide members
9.3CCND1, IL2RB, IL6, IL2
209.3IL6, BCL2L1
219.2BCL2, CDKN1A, VEGFA, CCND1
229.2CCND1, VEGFA, CDKN1A, BCL2
23
Hide members
9.1CCND1, CDKN1A, BCL2L1
24
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9.1BCL2L1, CDKN1A, CCND1
25
Development Thrombopoetin signaling via JAK-STAT pathway
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9.1BCL2L1, CDKN1A, CCND1
269.1BCL2, IL6, CDKN1A, VEGFA
279.1BCL2, BCL2L1, CCND1
28
Apoptosis and survival Apoptotic TNF-family pathways
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9.1CDKN1A, BCL2L1, BCL2
29
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9.1BCL2, BCL2L1, CDKN1A
30
Hide members
9.0CCND1, CDKN1A, IL2RB, IL6, IL2
319.0IL2, BCL2L1, BCL2
329.0BCL2L1, IL6, CCND1
33
Hide members
9.0IL6, BCL2L1, BCL2
34
Hide members
9.0CCND1, CDKN1A, IL6, IL2, BCL2
35
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8.8BCL2, BCL2L1, CDKN1A, CCND1
368.8IL2RB, IL2, BCL2L1, BCL2
37
Hide members
8.8BCL2, BCL2L1, IL2, IL2RB
388.8CDKN1A, IL2RB, IL6, BCL2L1
39
Hide members
8.8IFI27, B2M, IL2RB, IL6, IL2
40
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8.7CCND1, CDKN1A, IL2RB, IL6, IL2, BCL2
41
Hide members
8.7BCL2, BCL2L1, IL2, IL6
428.5CCND1, IL2RB, IL6, IL2, BCL2L1
43
Hide members
8.4BCL2L1, IL2, IGKC, VEGFA
44
Development PDGF signaling via STATs and NF-kB
Hide members
8.4CDKN1A, IL6, IL2, BCL2L1, BCL2
458.2CCND1, CDKN1A, IL2RB, IL6, IL2, BCL2L1
46
Hide members
8.1CCND1, CDKN1A, IL6, IL2, BCL2L1, BCL2
478.0CCND1, VEGFA, CDKN1A, IL6, BCL2L1, BCL2
48
Hide members
8.0IFI27, B2M, IGKC, CDKN1A, IL2RB, IL6
49
Hide members
7.9CCND1, CDKN1A, IL2RB, IL6, IL2, BCL2L1
507.5BCL2, CCND1, VEGFA, CDKN1A, IL2RB, IL6

Compounds for genes affiliated with Extramedullary Plasmacytoma

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Extramedullary Plasmacytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7IL2RB
2butyrate4510.5B2M
3depsipeptide4510.4CCND1
4gm-csf45 2911.0BCL2L1
5tamoxifen45 50 29 1112.8CCND1, CDKN1A, IL2RB, IL2
6optimax459.8CCND1, CDKN1A, IFI27
72,5-oligoadenylate459.5IL6, IL2, B2M, IL2RB
8eb 108945 6010.4BCL2, CDKN1A, CCND1, IFI27
9bucillamine459.4IL6, VEGFA, IL2
10triptolide459.4IL6, IL2, BCL2, VEGFA
11bryostatin 1459.2BCL2, CDKN1A, BCL2L1, IL2RB
12ciglitazone45 2910.1IL6, CDKN1A, CCND1, BCL2L1
13troglitazone45 29 60 1112.0IFI27, BCL2, CDKN1A, IL6, CCND1
14suberoylanilide hydroxamic acid458.9BCL2, CDKN1A, CCND1, BCL2L1
15geldanamycin45 50 60 1111.8CDKN1A, IL2RB, VEGFA, CCND1, BCL2L1
16adriamycin458.8BCL2L1, BCL2, CCND1, B2M, CDKN1A
17flavopiridol45 119.8CDKN1A, CCND1, BCL2, BCL2L1, VEGFA
18sp 60012545 609.8CDKN1A, BCL2L1, IL6, CCND1, BCL2
19rituximab45 50 1110.8IL6, B2M, IL2, BCL2, BCL2L1
20gemcitabine45 50 1110.8CCND1, VEGFA, CDKN1A, BCL2, BCL2L1
21indole-3-carbinol458.7CCND1, IFI27, BCL2L1, BCL2, CDKN1A
22sulindac45 119.7BCL2, CDKN1A, IFI27, CCND1, BCL2L1
232-methoxyestradiol45 60 2410.7CDKN1A, BCL2L1, BCL2, CCND1
24roscovitine458.7IFI27, CDKN1A, BCL2, CCND1, BCL2L1
25adpribose458.7IFI27, BCL2, CCND1, BCL2L1, CDKN1A
26thymidine45 249.6CDKN1A, IFI27, CCND1, IL2, IL6, B2M
27gefitinib45 50 1110.6CCND1, IFI27, BCL2L1, VEGFA, CDKN1A
28n-(4-hydroxyphenyl)retinamide458.5CCND1, BCL2L1, CDKN1A, BCL2
29thalidomide45 50 60 1111.5B2M, VEGFA, IL6, CCND1, BCL2L1, IL2
30bortezomib45 119.5CDKN1A, VEGFA, IL6, BCL2L1, BCL2, CCND1
31curcumin458.4CCND1, VEGFA, CDKN1A, IL6, BCL2L1, BCL2
32retinoid458.4IFI27, CCND1, CDKN1A, IL2RB, BCL2, BCL2L1
33quercetin45 60 11 2411.4BCL2L1, CCND1, BCL2, IFI27, IL2
34imatinib45 50 1110.4CCND1, BCL2, BCL2L1, VEGFA, CDKN1A
35sb 20358045 609.4BCL2L1, IL6, CCND1, VEGFA, CDKN1A, BCL2
36mg 13245 609.3BCL2L1, BCL2, CCND1, CDKN1A, IFI27, VEGFA
3715-deoxy-delta-12,14-prostaglandin j2458.3IL6, BCL2L1, CDKN1A, VEGFA, IFI27, CCND1
38paclitaxel45 50 1110.1BCL2L1, CDKN1A, VEGFA, IFI27, BCL2, CCND1
39pd 98,059458.1CDKN1A, IL6, BCL2L1, BCL2, CCND1, IFI27
40actinomycin d458.0BCL2, BCL2L1, IL2, IL6, CDKN1A, VEGFA
41thymidylate458.0BCL2L1, CDKN1A, BCL2, CCND1, IFI27, B2M
42doxorubicin45 50 1110.0BCL2, BCL2L1, IFI27, CDKN1A, CCND1, B2M
43paraffin458.0BCL2, BCL2L1, CDKN1A, IFI27, CCND1, VEGFA
44ly294002457.9IL6, BCL2, BCL2L1, IFI27, CCND1, CDKN1A
45rapamycin457.8IL2RB, CCND1, CDKN1A, IL2, IFI27, BCL2L1
46n acetylcysteine457.7BCL2L1, BCL2, IL6, IL2RB, CDKN1A, VEGFA
47retinoic acid45 248.6IL6, BCL2, IFI27, IL2RB, CDKN1A, CCND1
48cisplatin45 50 60 1110.5CCND1, IL2RB, IFI27, B2M, VEGFA, CDKN1A
49genistein45 29 60 2 11 2412.1IL2RB, CCND1, IFI27, B2M, BCL2, BCL2L1
50vegf457.1VEGFA, CCND1, IFI27, B2M, CDKN1A, IL2RB

GO Terms for genes affiliated with Extramedullary Plasmacytoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Extramedullary Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003079.7CDKN1A, CCND1
2mitochondrial outer membraneGO:0057418.8BCL2, BCL2L1, IFI27

Biological processes related to Extramedullary Plasmacytoma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1response to iron ionGO:01003910.1BCL2, CCND1
2positive regulation of immunoglobulin secretionGO:05102410.0IL2, IL6
3positive regulation of B cell proliferationGO:0308909.9CDKN1A, IL2, BCL2
4response to organonitrogen compoundGO:0102439.9CCND1, CDKN1A
5mammary gland alveolus developmentGO:0607499.8CCND1, VEGFA
6negative regulation of myeloid cell apoptotic processGO:0330339.8BCL2, MAEA
7positive regulation of peptidyl-serine phosphorylationGO:0331389.6VEGFA, IL6, BCL2
8negative regulation of intrinsic apoptotic signaling pathwayGO:20012439.5BCL2L1, BCL2
9regulation of mitochondrial membrane permeabilityGO:0469029.4BCL2L1, BCL2
10negative regulation of anoikisGO:20008119.4BCL2L1, BCL2
11regulation of mitochondrial membrane potentialGO:0518819.3BCL2, BCL2L1
12intrinsic apoptotic signaling pathwayGO:0971939.3BCL2, BCL2L1, CDKN1A
13cytokine-mediated signaling pathwayGO:0192219.3IFI27, B2M, IL2RB, IL6
14response to drugGO:0424939.3BCL2, IL6, CDKN1A, B2M, CCND1
15ovarian follicle developmentGO:0015419.2BCL2, BCL2L1, VEGFA
16negative regulation of autophagyGO:0105079.0BCL2, BCL2L1
17innate immune responseGO:0450878.5B2M, IGKC, CDKN1A, BCL2L1, BCL2
18negative regulation of apoptotic processGO:0430668.1BCL2, VEGFA, CDKN1A, IL2RB, IL6, IL2

Molecular functions related to Extramedullary Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BH3 domain bindingGO:0514349.3BCL2, BCL2L1

Products for genes affiliated with Extramedullary Plasmacytoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Extramedullary Plasmacytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet