MCID: EXT010
MIFTS: 55

Extramedullary Plasmacytoma malady

Cancer diseases category

Summaries for Extramedullary Plasmacytoma

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32MalaCards
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MalaCards: Extramedullary Plasmacytoma, also known as plasmacytoma, extramedullary, is related to plasmacytoma and myeloma. An important gene associated with Extramedullary Plasmacytoma is ZNF347 (zinc finger protein 347), and among its related pathways are Glioma and Downstream signaling in naive CD8+ T cells. The compounds cycloheximide and butyrate have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and colon, and related mouse phenotypes are homeostasis/metabolism and cardiovascular system.

Aliases & Classifications for Extramedullary Plasmacytoma

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

extramedullary plasmacytoma 8 60
plasmacytoma, extramedullary 8
extraosseous plasmacytoma 8


External Ids:

Disease Ontology8 DOID:3720
NCIt39 C4002
ICD1025 C90.2

Related Diseases for Extramedullary Plasmacytoma

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17GeneCards, 18GeneDecks
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Diseases related to Extramedullary Plasmacytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 182)
idRelated DiseaseScoreTop Affiliating Genes
1plasmacytoma32.1IL6, MAEA, IGKC, B2M
2myeloma31.1CCND1, IFI27, B2M, VEGFA, IGKC, CDKN1A
3multiple myeloma31.1CCND1, IL6, BCL2L1
4amyloidosis30.6IGKC, B2M
5sarcoma30.3IL2
6pancreatitis30.3IL6
7squamous cell carcinoma30.3CCND1, IFI27, MPP1, VEGFA, CDKN1A, BCL2L1
8pituitary adenoma30.1IFI27
9macroglobulinemia30.1B2M
10myasthenia gravis30.1IL2
11kaposi's sarcoma30.1IL6
12sarcoidosis30.1BCL2L1, IL2, IL2RB
13peritonitis30.1B2M, IL6
14colon adenocarcinoma30.1CDKN1A, BCL2L1, BCL2
15adenoma30.1CCND1, IFI27, CDKN1A, BCL2
16hodgkin's lymphoma30.1BCL2, BCL2L1, IL2, IL2RB, MPP1
17adenocarcinoma30.1CCND1, IFI27, VEGFA, CDKN1A, BCL2L1, BCL2
18bladder carcinoma30.1CCND1, IFI27, VEGFA, CDKN1A, IL2, BCL2L1
19breast cancer30.1CCND1, IFI27, VEGFA, CDKN1A, IL2, BCL2L1
20melanoma30.1CCND1, IFI27, MPP1, VEGFA, CDKN1A, IL2RB
21leukemia30.1CCND1, IFI27, B2M, IGKC, CDKN1A, IL2RB
22thyroiditis10.7
23tonsillitis10.5
24mediastinitis10.4
25cervicitis10.4
26obstructive jaundice10.2
27intussusception10.2
28nasopharyngitis10.2
29cardiac tamponade10.1
30extrahepatic cholestasis10.1
31cholestasis10.1
32crohn's disease10.1
33tolosa-hunt syndrome10.1
34colon lymphoma10.1
35papillary carcinoma10.1
36choroiditis10.1
37thyroid lymphoma10.1
38orbital cellulitis10.1
39multinodular goiter10.1
40cellulitis10.1
41larynx carcinoma in situ10.1
42exophthalmos10.1
43sialadenitis10.1
44ulcerative colitis10.1
45duodenitis10.1
46solitary osseous plasmacytoma10.1
47adenoiditis10.1
48bladder transitional cell carcinoma10.1
49colonic disease10.1
50dacryocystitis10.1

Graphical network of the top 20 diseases related to Extramedullary Plasmacytoma:



Diseases related to extramedullary plasmacytoma

Clinical Features for Extramedullary Plasmacytoma

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Drugs & Therapeutics for Extramedullary Plasmacytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Extramedullary Plasmacytoma

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Anatomical Context for Extramedullary Plasmacytoma

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32MalaCards
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MalaCards organs/tissues related to Extramedullary Plasmacytoma:

32
Bone, Thyroid, Colon, Breast, Pancreas, Tonsil, Tongue, Lymph node, Liver, Heart, Small intestine, Salivary gland, Skin, Lung, Bone marrow, Adrenal gland, Trachea, Skeletal muscle, Kidney, Testis, Pituitary, B cells, Cervix, Spinal cord

Animal Models for Extramedullary Plasmacytoma or affiliated genes

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36MGI
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Publications for Extramedullary Plasmacytoma

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50PubMed
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Articles related to Extramedullary Plasmacytoma:

(show top 50)    (show all 459)
idTitleAuthorsYear
1
Primary extramedullary plasmacytoma of the heart: a rare manifestation of plasmacellular tumor. (24386583)
2013
2
A case of extramedullary plasmacytoma in the sphenoid sinus with unilateral loss of vision. (22795167)
2013
3
Extramedullary Plasmacytoma of the Trachea. (24046059)
2013
4
Extramedullary plasmacytoma of the tongue base: a rare presentation of head and neck plasmacytoma. (24313182)
2013
5
Surgery and radiation therapy for extramedullary plasmacytoma of the penile mucosa in a dog. (23450865)
2012
6
A case of extramedullary solitary plasmacytoma arising at the uterine cervix. (23091904)
2012
7
Extramedullary laryngeal plasmacytoma in a dog. (22175432)
2012
8
Solitary Extramedullary Plasmacytoma of the Apex of Arytenoid: Endoscopic, CT, and Pathologic Findings. (22737292)
2012
9
Extramedullary plasmacytoma of the small intestine: clinical features, diagnosis and treatment. (22188911)
2012
10
Aggressive and fatal extramedullary plasmacytoma: a report of two cases. (20477820)
2010
11
Soft tissue extramedullary plasmacytoma. (20204131)
2010
12
Pathology quiz case 2: extramedullary plasmacytoma (EMP). (20578292)
2010
13
Extramedullary plasmacytoma of the third eyelid gland in a dog. (19261165)
2009
14
Autologous bone marrow transplanation for extramedullary plasmacytoma presenting as adrenal incidentaloma. (19448366)
2009
15
Treatment of solitary extramedullary plasmacytoma of the stomach with endoscopic submucosal dissection. (20431772)
2009
16
Successful treatment of extramedullary gastric plasmacytoma with the combination of bortezomib and dexamethasone: first reported case. (17560647)
2008
17
A pleural effusion due to extramedullary pleural plasmacytoma: a case report. (18265936)
2008
18
Extramedullary plasmacytoma: clinicopathology, immunohistochemistry and therapeutic approach to a case with a tonsillar site. (20058481)
2008
19
Extramedullary plasmacytoma presenting as a nasal mass in an immunosuppressed patient: treatment after failed primary radiotherapy. (18478798)
2008
20
Solitary extramedullary plasmacytoma and granulomatous sialadenitis of the parotid gland preceding a B-cell non-Hodgkin's lymphoma. (16489463)
2006
21
Extramedullary plasmacytoma: report of two cases with uncommon presentation. (15042315)
2005
22
CT and MRI findings of a solitary extramedullary plasmacytoma of the oropharynx: case report. (16555568)
2005
23
Thyroid enlargement due to extramedullary plasmacytoma. (15174806)
2004
24
Unilateral exophthalmos caused by an extramedullary plasmacytoma: a case report. (23365508)
2003
25
Intraocular extramedullary plasmacytoma in a cat. (12753623)
2003
26
A case of extramedullary plasmacytoma of the larynx. (12212582)
2002
27
An unusual presentation of extramedullary plasmacytoma occurring sequentially in the testis, subcutaneous tissue, and heart. (11391718)
2001
28
Extramedullary plasmacytoma of the larynx: a case report. (11676113)
2001
29
Extramedullary plasmacytoma of the hand: a case report. (11466658)
2001
30
Extramedullary plasmacytoma of the orbit. (11037925)
2000
31
Primary extramedullary plasmacytoma of the palate. (10187947)
1999
32
Extramedullary plasmacytoma of the head and neck associated with the human immunodeficiency virus. (9473836)
1998
33
Solitary extramedullary plasmacytoma in the retroperitoneum. (9662276)
1998
34
Extramedullary plasmacytoma of maxillary sinus with later involvement of the gall bladder and subcutaneous tissues. (8580064)
1995
35
Metastatic extramedullary plasmacytoma of the colon and rectum in a dog. (7693631)
1993
36
IgG-kappa extramedullary plasmacytoma of the conjunctiva and orbit. (8494868)
1993
37
Extramedullary plasmacytoma: cytological and genotypic studies. (8217765)
1993
38
Solitary extramedullary plasmacytoma of the maxillary antrum and orbit presenting as acute bacterial orbital cellulitis. (1854702)
1991
39
Spontaneous regression of extramedullary plasmacytoma--a case report. (3172588)
1988
40
Biliary obstruction secondary to an extramedullary plasmacytoma of the pancreas: confusion with pancreatitis on computed tomography. (3628227)
1987
41
Extramedullary plasmacytoma. (6508632)
1984
42
Extramedullary plasmacytoma: simulating a soft tissue sarcoma of the chest wall. (7392636)
1980
43
Solitary extramedullary plasmacytoma of the larynx. (836244)
1977
44
Pathologic quiz case 1: extramedullary plasmacytoma of the larynx. (938330)
1976
45
Extramedullary plasmacytoma of the breast. (1151529)
1975
46
The extramedullary plasmacytoma, benign or malignant? (4500485)
1972
47
Solitary extramedullary plasmacytoma of the skin. A review of the world literature and the report of an addiional case. (5424538)
1970
48
Clinical and live-cell study of extramedullary plasmacytoma of the upper respiratory tract. (5334446)
1967
49
Multiple myeloma with a large extramedullary plasmacytoma of the thorax treated with prednisone and radiation. metabolic balance study demonstrating unusual beneficial systemic effects of radiation ablation of the plasmacytoma. (13913686)
1962
50
Extramedullary plasmacytoma of the bladder with local metastasis. (18146914)
1949

Genetic Variations for Extramedullary Plasmacytoma

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Expression for genes affiliated with Extramedullary Plasmacytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Extramedullary Plasmacytoma

Search GEO for disease gene expression data for Extramedullary Plasmacytoma.

Pathways for genes affiliated with Extramedullary Plasmacytoma

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29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 51QIAGEN, 52R&D Systems, 55SinoBiological
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Pathways related to Extramedullary Plasmacytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2CDKN1A
29.7B2M, IL2RB, IL2
3
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9.7IL2, IL2RB, B2M
49.6BCL2, CDKN1A, CCND1
59.6BCL2, CDKN1A, CCND1
6
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9.6IL2RB, IL2, BCL2
7
Transcription Androgen Receptor nuclear signaling
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9.6IL6, CDKN1A, CCND1
8
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9.6IL2, IL6, IL2RB
99.5IL2, IL6, CCND1
109.5CDKN1A, IL6, IL2
119.5CCND1, IL6, BCL2
129.5CDKN1A, IL6, BCL2
13
Transcription P53 signaling pathway
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9.5VEGFA, CDKN1A, BCL2
14
Immune response Oncostatin M signaling via JAK-Stat in human cells
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9.4CCND1, VEGFA, IL6
15
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9.4CCND1, IL2RB, IL2, BCL2
169.3BCL2L1, BCL2
17
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9.3BCL2, BCL2L1
18
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9.3BCL2, BCL2L1
19
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9.3CCND1, IL2RB, IL6, IL2
209.3IL6, BCL2L1
219.2BCL2, CDKN1A, VEGFA, CCND1
229.2CCND1, VEGFA, CDKN1A, BCL2
23
Hide members
9.1CCND1, CDKN1A, BCL2L1
24
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9.1BCL2L1, CDKN1A, CCND1
25
Development Thrombopoetin signaling via JAK-STAT pathway
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9.1BCL2L1, CDKN1A, CCND1
269.1BCL2, IL6, CDKN1A, VEGFA
279.1BCL2, BCL2L1, CCND1
28
Apoptosis and survival Apoptotic TNF-family pathways
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9.1CDKN1A, BCL2L1, BCL2
29
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9.1BCL2, BCL2L1, CDKN1A
30
Hide members
9.0CCND1, CDKN1A, IL2RB, IL6, IL2
319.0IL2, BCL2L1, BCL2
329.0BCL2L1, IL6, CCND1
33
Hide members
9.0IL6, BCL2L1, BCL2
34
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9.0CCND1, CDKN1A, IL6, IL2, BCL2
35
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8.8BCL2, BCL2L1, CDKN1A, CCND1
368.8IL2RB, IL2, BCL2L1, BCL2
37
Hide members
8.8BCL2, BCL2L1, IL2, IL2RB
388.8CDKN1A, IL2RB, IL6, BCL2L1
39
Hide members
8.8IFI27, B2M, IL2RB, IL6, IL2
40
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8.7CCND1, CDKN1A, IL2RB, IL6, IL2, BCL2
41
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8.7BCL2, BCL2L1, IL2, IL6
428.5CCND1, IL2RB, IL6, IL2, BCL2L1
43
Hide members
8.4BCL2L1, IL2, IGKC, VEGFA
44
Development PDGF signaling via STATs and NF-kB
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8.4CDKN1A, IL6, IL2, BCL2L1, BCL2
458.2CCND1, CDKN1A, IL2RB, IL6, IL2, BCL2L1
46
Hide members
8.1CCND1, CDKN1A, IL6, IL2, BCL2L1, BCL2
478.0CCND1, VEGFA, CDKN1A, IL6, BCL2L1, BCL2
48
Hide members
8.0IFI27, B2M, IGKC, CDKN1A, IL2RB, IL6
49
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7.9CCND1, CDKN1A, IL2RB, IL6, IL2, BCL2L1
507.5BCL2, CCND1, VEGFA, CDKN1A, IL2RB, IL6

Compounds for genes affiliated with Extramedullary Plasmacytoma

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Extramedullary Plasmacytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7IL2RB
2butyrate4410.5B2M
3depsipeptide4410.4CCND1
4gm-csf44 2811.0BCL2L1
5tamoxifen44 49 28 1112.8CCND1, CDKN1A, IL2RB, IL2
6optimax449.8CCND1, CDKN1A, IFI27
72,5-oligoadenylate449.5IL6, IL2, B2M, IL2RB
8eb 108944 5910.4BCL2, CDKN1A, CCND1, IFI27
9bucillamine449.4IL6, VEGFA, IL2
10triptolide449.4IL6, IL2, BCL2, VEGFA
11bryostatin 1449.2BCL2, CDKN1A, BCL2L1, IL2RB
12ciglitazone44 2810.1IL6, CDKN1A, CCND1, BCL2L1
13troglitazone44 28 59 1112.0IFI27, BCL2, CDKN1A, IL6, CCND1
14suberoylanilide hydroxamic acid448.9BCL2, CDKN1A, CCND1, BCL2L1
15geldanamycin44 49 59 1111.8CDKN1A, IL2RB, VEGFA, CCND1, BCL2L1
16adriamycin448.8BCL2L1, BCL2, CCND1, B2M, CDKN1A
17flavopiridol44 119.8CDKN1A, CCND1, BCL2, BCL2L1, VEGFA
18sp 60012544 599.8CDKN1A, BCL2L1, IL6, CCND1, BCL2
19rituximab44 49 1110.8IL6, B2M, IL2, BCL2, BCL2L1
20gemcitabine44 49 1110.8CCND1, VEGFA, CDKN1A, BCL2, BCL2L1
21indole-3-carbinol448.7CCND1, IFI27, BCL2L1, BCL2, CDKN1A
22sulindac44 119.7BCL2, CDKN1A, IFI27, CCND1, BCL2L1
232-methoxyestradiol44 59 2410.7CDKN1A, BCL2L1, BCL2, CCND1
24roscovitine448.7IFI27, CDKN1A, BCL2, CCND1, BCL2L1
25adpribose448.7IFI27, BCL2, CCND1, BCL2L1, CDKN1A
26thymidine44 249.6CDKN1A, IFI27, CCND1, IL2, IL6, B2M
27gefitinib44 49 1110.6CCND1, IFI27, BCL2L1, VEGFA, CDKN1A
28n-(4-hydroxyphenyl)retinamide448.5CCND1, BCL2L1, CDKN1A, BCL2
29thalidomide44 49 59 1111.5B2M, VEGFA, IL6, CCND1, BCL2L1, IL2
30bortezomib44 119.5CDKN1A, VEGFA, IL6, BCL2L1, BCL2, CCND1
31curcumin448.4CCND1, VEGFA, CDKN1A, IL6, BCL2L1, BCL2
32retinoid448.4IFI27, CCND1, CDKN1A, IL2RB, BCL2, BCL2L1
33quercetin44 59 11 2411.4BCL2L1, CCND1, BCL2, IFI27, IL2
34imatinib44 49 1110.4CCND1, BCL2, BCL2L1, VEGFA, CDKN1A
35sb 20358044 599.4BCL2L1, IL6, CCND1, VEGFA, CDKN1A, BCL2
36mg 13244 599.3BCL2L1, BCL2, CCND1, CDKN1A, IFI27, VEGFA
3715-deoxy-delta-12,14-prostaglandin j2448.3IL6, BCL2L1, CDKN1A, VEGFA, IFI27, CCND1
38paclitaxel44 49 1110.1BCL2L1, CDKN1A, VEGFA, IFI27, BCL2, CCND1
39pd 98,059448.1CDKN1A, IL6, BCL2L1, BCL2, CCND1, IFI27
40actinomycin d448.0BCL2, BCL2L1, IL2, IL6, CDKN1A, VEGFA
41thymidylate448.0BCL2L1, CDKN1A, BCL2, CCND1, IFI27, B2M
42doxorubicin44 49 1110.0BCL2, BCL2L1, IFI27, CDKN1A, CCND1, B2M
43paraffin448.0BCL2, BCL2L1, CDKN1A, IFI27, CCND1, VEGFA
44ly294002447.9IL6, BCL2, BCL2L1, IFI27, CCND1, CDKN1A
45rapamycin447.8IL2RB, CCND1, CDKN1A, IL2, IFI27, BCL2L1
46n acetylcysteine447.7BCL2L1, BCL2, IL6, IL2RB, CDKN1A, VEGFA
47retinoic acid44 248.6IL6, BCL2, IFI27, IL2RB, CDKN1A, CCND1
48cisplatin44 49 59 1110.5CCND1, IL2RB, IFI27, B2M, VEGFA, CDKN1A
49genistein44 28 59 2 11 2412.1IL2RB, CCND1, IFI27, B2M, BCL2, BCL2L1
50vegf447.1VEGFA, CCND1, IFI27, B2M, CDKN1A, IL2RB

GO Terms for genes affiliated with Extramedullary Plasmacytoma

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16Gene Ontology
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Cellular components related to Extramedullary Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclin-dependent protein kinase holoenzyme complexGO:0003079.7CDKN1A, CCND1
2mitochondrial outer membraneGO:0057418.8BCL2, BCL2L1, IFI27

Biological processes related to Extramedullary Plasmacytoma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1response to iron ionGO:01003910.1BCL2, CCND1
2positive regulation of immunoglobulin secretionGO:05102410.0IL2, IL6
3positive regulation of B cell proliferationGO:0308909.9CDKN1A, IL2, BCL2
4response to organonitrogen compoundGO:0102439.9CCND1, CDKN1A
5mammary gland alveolus developmentGO:0607499.8CCND1, VEGFA
6negative regulation of myeloid cell apoptotic processGO:0330339.8BCL2, MAEA
7positive regulation of peptidyl-serine phosphorylationGO:0331389.6VEGFA, IL6, BCL2
8negative regulation of intrinsic apoptotic signaling pathwayGO:20012439.5BCL2L1, BCL2
9regulation of mitochondrial membrane permeabilityGO:0469029.4BCL2L1, BCL2
10negative regulation of anoikisGO:20008119.4BCL2L1, BCL2
11regulation of mitochondrial membrane potentialGO:0518819.3BCL2, BCL2L1
12intrinsic apoptotic signaling pathwayGO:0971939.3BCL2, BCL2L1, CDKN1A
13cytokine-mediated signaling pathwayGO:0192219.3IFI27, B2M, IL2RB, IL6
14response to drugGO:0424939.3BCL2, IL6, CDKN1A, B2M, CCND1
15ovarian follicle developmentGO:0015419.2BCL2, BCL2L1, VEGFA
16negative regulation of autophagyGO:0105079.0BCL2, BCL2L1
17innate immune responseGO:0450878.5B2M, IGKC, CDKN1A, BCL2L1, BCL2
18negative regulation of apoptotic processGO:0430668.1BCL2, VEGFA, CDKN1A, IL2RB, IL6, IL2

Molecular functions related to Extramedullary Plasmacytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1BH3 domain bindingGO:0514349.3BCL2, BCL2L1

Products for genes affiliated with Extramedullary Plasmacytoma

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Sources for Extramedullary Plasmacytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet