Extraosseous Ewing's Sarcoma malady

MalaCards: Extraosseous Ewing's Sarcoma, also known as extraosseous ewing's sarcoma/peripheral primitive neuroectodermal tumor, is related to peripheral primitive neuroectodermal tumor and sarcoma. An important gene associated with Extraosseous Ewing's Sarcoma is CD99 (CD99 molecule). The drugs etoposide phosphate and etoposide and the compounds paraffin and vegf have been mentioned in the context of this disorder. Related mouse phenotype tumorigenesis.

Aliases & Descriptions:

extraosseous ewing's sarcoma 6 extraosseous ewing's sarcoma/peripheral primitive neuroectodermal tumor 6 extraosseous ewings sarcoma-primitive neuroepithelial tumor 43

sarcoma extraosseous ewings 32 extraosseous ewings sarcoma 8 ewings sarcoma 43

Diseases related to extraosseous ewing's sarcoma by text searches and GeneDecks gene sharing:

(show all 44)

id	Related Disease	Score	Top Affiliating Genes
1	peripheral primitive neuroectodermal tumor	33.8	EWSR1, CD99, S100B
2	sarcoma	31.1	MYF6, S100B, CD99, EWSR1, ETV4
3	neuroectodermal tumors	30.1	S100B, CD99, EWSR1
4	neuroblastoma	29.6	ETV4, EWSR1, CD99, S100B
5	synovial sarcoma	29.6	EWSR1, CD99, S100B
6	osteosarcoma	29.4	ETV4, EWSR1, CD99, S100B
7	malignant peripheral nerve sheath tumor	28.4	S100B, ETV4
8	olfactory neuroblastoma	28.1	S100B, EWSR1
9	desmoplastic small round cell tumor	27.6	S100B, CD99, EWSR1
10	melanoma	26.2	ETV4, EWSR1, CD99, S100B
11	esthesioneuroblastoma	12.8	S100B, CD99
12	supratentorial primitive neuroectodermal tumor	12.8	CD99, S100B
13	ectomesenchymoma	12.8	MYF6, CD99
14	ganglioneuroma	12.7	S100B, CD99
15	central nervous system cancer	12.6	CD99, EWSR1
16	merkel cell carcinoma	12.6	S100B, CD99
17	rhabdoid tumors	12.5	S100B, MYF6
18	myoepithelioma	12.4	S100B, EWSR1
19	neuroepithelioma	12.4	CD99, EWSR1
20	extraskeletal myxoid chondrosarcoma	12.4	S100B, EWSR1
21	myxoid chondrosarcoma	12.4	S100B, EWSR1
22	kidney clear cell sarcoma	12.4	EWSR1, S100B
23	chordoma	12.2	S100B, EWSR1
24	constipation	12.1	EWSR1, S100B
25	cerebral primitive neuroectodermal tumor	12.0	EWSR1, CD99, S100B
26	fibrous histiocytoma	12.0	S100B, CD99, EWSR1
27	histiocytoma	12.0	EWSR1, CD99, S100B
28	malignant fibrous histiocytoma	11.8	S100B, EWSR1
29	malignant glioma	11.6	S100B, CD99, EWSR1
30	rhabdomyosarcoma	11.4	MYF6, S100B, CD99, EWSR1
31	extraosseous ewings sarcoma-primitive neuroepithelial tumor	10.8
32	primitive neuroectodermal tumor	9.3
33	vaginitis	8.0
34	localized ewing's sarcoma	7.7
35	neurofibromatosis	6.3
36	neutropenia	6.3
37	ring chromosomes	6.3
38	retinoblastoma	6.3
39	soft tissue peripheral neuroepithelioma	6.3
40	askin's tumor	6.3
41	bone localized ewing's sarcoma	6.3
42	bone ewing's sarcoma	6.3
43	ewing's family localized tumor	6.3
44	lymphoblastic lymphoma	6.3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cyclophosphamide, dactinomycin, etoposide, etoposide phosphate

MGI Mouse Phenotypes related to extraosseous ewing's sarcoma:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	tumorigenesis	MP:0002006	8.5	MYF6, EWSR1, ETV4

Articles related to extraosseous ewing's sarcoma:

id	Title	Authors	Year	Affiliating Genes
1	The first report of extraosseous Ewing's sarcoma in the rectovaginal septum. (12400989)	Petkovic M.... Antulov R.	2002	CD99
2	Primary vulvar and vaginal extraosseous Ewing's sarcoma/peripheral neuroectodermal tumor: diagnostic confirmation with CD99 immunostaining and reverse transcriptase-polymerase chain reaction. (10782405)	Vang R.... Silver S.A.	2000	CD99
3	A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma. (8605035)	Urano F.... Hata J.	1996	EWSR1, ETV4
4	Patterns of differentiation in extraosseous Ewing's sarcoma cells. An in vitro study. (7507797)	Noguera R.... Llombart-Bosch A.	1994	S100B

Genes related to extraosseous ewing's sarcoma according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CD99	CD99 molecule	11.0	Publications
2	ETV4	ets variant 4	11.0	Publications
3	MYF6	myogenic factor 6 (herculin)	11.0
4	EWSR1	Ewing sarcoma breakpoint region 1	11.0	Publications
5	S100B	S100 calcium binding protein B	11.0	Publications

Compounds related to extraosseous ewing's sarcoma according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	paraffin32	8.7	S100B, CD99, EWSR1
2	vegf32	8.7	ETV4, CD99, S100B
3	arginine32	8.6	S100B, EWSR1, ETV4
4	cyclic amp32 18	9.5	S100B, EWSR1, ETV4