EOE
MCID: EXT052
MIFTS: 24

Extraskeletal Ewing Sarcoma (EOE) malady

Cancer diseases, Rare diseases categories
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Summaries for Extraskeletal Ewing Sarcoma

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33MalaCards
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MalaCards: Extraskeletal Ewing Sarcoma, also known as extraosseous ewing sarcoma, is related to sarcoma and peripheral primitive neuroectodermal tumor. An important gene associated with Extraskeletal Ewing Sarcoma is SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5), and among its related pathways is Transcriptional misregulation in cancer. Related mouse phenotypes are tumorigenesis and hematopoietic system.

Aliases & Classifications for Extraskeletal Ewing Sarcoma

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49Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Aliases & Descriptions:

extraskeletal ewing sarcoma 49
extraosseous ewing sarcoma 49
extraskeletal ewing tumor 49
extraosseous ewing tumor 49
eoe 49


Related Diseases for Extraskeletal Ewing Sarcoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Extraskeletal Ewing Sarcoma:



Diseases related to extraskeletal ewing sarcoma

Symptoms for Extraskeletal Ewing Sarcoma

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Drugs & Therapeutics for Extraskeletal Ewing Sarcoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Extraskeletal Ewing Sarcoma

Genetic Tests for Extraskeletal Ewing Sarcoma

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Anatomical Context for Extraskeletal Ewing Sarcoma

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Animal Models for Extraskeletal Ewing Sarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Extraskeletal Ewing Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8EWSR1, SMARCA5, FLI1
2MP:00053978.5ERG, FLI1, EWSR1
3MP:00053808.3ERG, FLI1, SMARCA5
4MP:00107687.9ERG, EWSR1, SMARCA5, FLI1

Publications for Extraskeletal Ewing Sarcoma

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52PubMed
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Articles related to Extraskeletal Ewing Sarcoma:

idTitleAuthorsYear
1
Retraction note to: CT and MR findings in a neuroforaminal extraskeletal Ewing sarcoma mimicking benign nerve sheath tumor. Ir J Med Sci (2012) 181:123-5. (24136179)
2013
2
Extraskeletal Ewing sarcoma in children and adolescents: impact of narrow but negative surgical margin. (23982393)
2013
3
A novel t(4;22)(q31;q12) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor. (21113140)
2011
4
Primitive neuroectodermal tumor and extraskeletal Ewing sarcoma arising primarily around the spinal column: report of four cases and a review of the literature. (14520055)
2003

Variations for Extraskeletal Ewing Sarcoma

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Expression for genes affiliated with Extraskeletal Ewing Sarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Extraskeletal Ewing Sarcoma

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Pathways for genes affiliated with Extraskeletal Ewing Sarcoma

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50PathCards, 30KEGG
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Pathways related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.5ERG, FLI1, EWSR1

Compounds for genes affiliated with Extraskeletal Ewing Sarcoma

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GO Terms for genes affiliated with Extraskeletal Ewing Sarcoma

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16Gene Ontology
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Cellular components related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.0ERG, FLI1, SMARCA5, EWSR1

Biological processes related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription from RNA polymerase II promoterGO:0063669.1ERG, FLI1
2cell differentiationGO:0301548.8ERG, FLI1
3regulation of transcription from RNA polymerase II promoterGO:0063578.5ERG, FLI1, SMARCA5

Molecular functions related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0009818.8ERG, FLI1
2DNA bindingGO:0036778.6ERG, FLI1, SMARCA5

Products for genes affiliated with Extraskeletal Ewing Sarcoma

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Sources for Extraskeletal Ewing Sarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet