EOE
MCID: EXT052
MIFTS: 28

Extraskeletal Ewing Sarcoma (EOE) malady

Cancer diseases category

Summaries for Extraskeletal Ewing Sarcoma

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32MalaCards
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MalaCards: Extraskeletal Ewing Sarcoma, also known as extraosseous ewing sarcoma, is related to sarcoma and peripheral primitive neuroectodermal tumor. An important gene associated with Extraskeletal Ewing Sarcoma is EWSR1 (EWS RNA-binding protein 1), and among its related pathways is Transcriptional misregulation in cancer. The compounds glycogen and serine have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and mortality/aging.

Aliases & Classifications for Extraskeletal Ewing Sarcoma

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48Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

extraskeletal ewing sarcoma 48
extraosseous ewing sarcoma 48
extraskeletal ewing tumor 48
extraosseous ewing tumor 48
eoe 48


Related Diseases for Extraskeletal Ewing Sarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Extraskeletal Ewing Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma30.7VIM, EWSR1, FLI1, DES, MUC1, CD99
2peripheral primitive neuroectodermal tumor30.3FUS, ENO2, CD99, FLI1, EWSR1
3extraosseous ewings sarcoma-primitive neuroepithelial tumor10.5
4eosinophilic esophagitis10.4
5primitive neuroectodermal tumor10.4
6extraosseous ewing's sarcoma10.4
7esophagitis10.3
8ovary sarcoma10.3
9thyroid sarcoma10.3
10thyroiditis10.3
11ewing's family of tumors10.3
12embryonal tumor with multilayered rosettes10.3
13extracranial arteriovenous malformation10.3
14eosinophilia10.0
15nephroblastoma10.0EWSR1
16central nervous system cancer10.0ENO2
17epulis10.0ENO2
18rhabdoid cancer10.0ENO2
19neurilemmoma10.0ENO2
20seminoma10.0ENO2
21thymoma10.0PTPRC
22infantile myofibromatosis10.0DES
23sertoli-leydig cell tumor10.0MUC1
24thymus cancer10.0MUC1
25lymphangioleiomyomatosis10.0DES
26adenomatoid tumor10.0VIM
27syringoma10.0MUC1
28rheumatoid arthritis10.0PTPRC
29cystadenocarcinoma10.0MUC1
30subependymal giant cell astrocytoma10.0ENO2
31fibrous meningioma10.0MUC1
32teratoma10.0ENO2, CD99
33stomach cancer10.0CD99
34lipoma10.0FUS, DES
35myositis10.0PTPRC
36hidradenoma10.0MUC1
37hemangioma10.0FLI1
38clear cell sarcoma10.0FUS, EWSR1
39medulloblastoma10.0ENO2, DES
40acute leukemia10.0PTPRC, EWSR1
41myoepithelioma10.0VIM, EWSR1
42hemangioblastoma10.0ENO2, MUC1
43inflammatory myofibroblastic tumor10.0DES, PTPRC
44glomus tumor10.0VIM, DES
45retinoblastoma10.0ENO2, PTPRC
46epidermolysis bullosa simplex10.0DES
47adenoma10.0ENO2, MUC1
48epithelioid leiomyosarcoma10.0VIM, DES
49alveolar rhabdomyosarcoma10.0DES, ENO2
50pseudosarcomatous fibromatosis10.0VIM, DES

Graphical network of the top 20 diseases related to Extraskeletal Ewing Sarcoma:



Diseases related to extraskeletal ewing sarcoma

Clinical Features for Extraskeletal Ewing Sarcoma

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Drugs & Therapeutics for Extraskeletal Ewing Sarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Extraskeletal Ewing Sarcoma

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Anatomical Context for Extraskeletal Ewing Sarcoma

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Animal Models for Extraskeletal Ewing Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Extraskeletal Ewing Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3EWSR1, FLI1, MUC1, PTPRC, SMARCA5
2MP:00107687.4EWSR1, FLI1, DES, PTPRC, ERG, FUS
3MP:00053847.2SMARCA5, VIM, EWSR1, FLI1, PTPRC, ERG

Publications for Extraskeletal Ewing Sarcoma

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Genetic Variations for Extraskeletal Ewing Sarcoma

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Expression for genes affiliated with Extraskeletal Ewing Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Extraskeletal Ewing Sarcoma

Search GEO for disease gene expression data for Extraskeletal Ewing Sarcoma.

Pathways for genes affiliated with Extraskeletal Ewing Sarcoma

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29KEGG
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Pathways related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2FUS, ERG, FLI1, EWSR1

Compounds for genes affiliated with Extraskeletal Ewing Sarcoma

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1glycogen44 2411.4PTPRC
2serine4410.1DES, EWSR1
3askin4410.0ENO2, EWSR1
4periodate449.8PTPRC, MUC1
5orcein449.8VIM, DES
6heparin44 28 11 2412.8PTPRC, DES
7monochloroacetic acid449.7PTPRC, VIM
8eosin449.6VIM, MUC1
9fluorochrome449.5VIM, PTPRC
10phalloidin449.4DES, VIM
11[alcl]449.4PTPRC, MUC1
12reticulin449.3VIM, DES, MUC1
13mucicarmine449.3MUC1, DES, VIM
14progestin449.2MUC1, DES, VIM
15biotin44 11 2411.2VIM, DES, MUC1
16sialic acid449.2ENO2, PTPRC, MUC1
17adriamycin449.2MUC1, DES, VIM
18bromodeoxyuridine449.1VIM, DES, ENO2
19dihydrotestosterone44 28 11 2412.1MUC1, DES, VIM
20acth449.0MUC1, PTPRC, ENO2
21toluidine448.9ENO2, PTPRC, DES, VIM
22b 723448.9PTPRC, MUC1, DES, VIM
23ganglioside448.9ENO2, PTPRC, DES, VIM
24s 100448.8ENO2, MUC1, DES, VIM
2512-o-tetradecanoylphorbol 13-acetate448.8PTPRC, MUC1, DES, VIM
26dmso448.7VIM, MUC1, PTPRC, ENO2
27cyclic amp44 249.7MUC1, DES, EWSR1, VIM
28methotrexate44 49 1110.5ENO2, MUC1, VIM
29retinoic acid44 249.4VIM, EWSR1, DES, MUC1, ENO2
30hematoxylin448.3VIM, DES, MUC1, PTPRC, ENO2
31hyaluronic acid44 249.3VIM, DES, MUC1, PTPRC, ENO2
32formaldehyde44 249.3VIM, DES, MUC1, PTPRC, ENO2
33progesterone44 59 28 11 2412.3VIM, DES, MUC1, PTPRC, ENO2
34testosterone44 59 11 2411.3VIM, DES, MUC1, PTPRC, ENO2
35vegf447.9ENO2, CD99, MUC1, DES, VIM
36paraffin447.2VIM, EWSR1, DES, MUC1, CD99, PTPRC

GO Terms for genes affiliated with Extraskeletal Ewing Sarcoma

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16Gene Ontology
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Molecular functions related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428028.8FUS, DES, EWSR1, VIM

Products for genes affiliated with Extraskeletal Ewing Sarcoma

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Sources for Extraskeletal Ewing Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet