EOE
MCID: EXT052
MIFTS: 24

Extraskeletal Ewing Sarcoma (EOE) malady

Cancer diseases, Rare diseases categories

Summaries for Extraskeletal Ewing Sarcoma

About this section
Sources:
34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Extraskeletal Ewing Sarcoma, also known as extraosseous ewing sarcoma, is related to sarcoma and peripheral primitive neuroectodermal tumor. An important gene associated with Extraskeletal Ewing Sarcoma is SMARCA5 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5), and among its related pathways is Transcriptional misregulation in cancer. Related mouse phenotypes are tumorigenesis and hematopoietic system.

Aliases & Classifications for Extraskeletal Ewing Sarcoma

About this section
Sources:
50Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 50 
Rare tumors


Aliases & Descriptions:

extraskeletal ewing sarcoma 50
extraosseous ewing sarcoma 50
extraskeletal ewing tumor 50
extraosseous ewing tumor 50
eoe 50


Related Diseases for Extraskeletal Ewing Sarcoma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Graphical network of the top 20 diseases related to Extraskeletal Ewing Sarcoma:



Diseases related to extraskeletal ewing sarcoma

Symptoms for Extraskeletal Ewing Sarcoma

About this section

Drugs & Therapeutics for Extraskeletal Ewing Sarcoma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Extraskeletal Ewing Sarcoma

Drug clinical trials:

Search ClinicalTrials for Extraskeletal Ewing Sarcoma

Search NIH Clinical Center for Extraskeletal Ewing Sarcoma

Search CenterWatch for Extraskeletal Ewing Sarcoma

Genetic Tests for Extraskeletal Ewing Sarcoma

About this section

Anatomical Context for Extraskeletal Ewing Sarcoma

About this section

Animal Models for Extraskeletal Ewing Sarcoma or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Extraskeletal Ewing Sarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8EWSR1, SMARCA5, FLI1
2MP:00053978.5ERG, FLI1, EWSR1
3MP:00053808.3ERG, FLI1, SMARCA5
4MP:00107687.9ERG, EWSR1, SMARCA5, FLI1

Publications for Extraskeletal Ewing Sarcoma

About this section
Sources:
53PubMed
See all sources

Articles related to Extraskeletal Ewing Sarcoma:

idTitleAuthorsYear
1
Retraction note to: CT and MR findings in a neuroforaminal extraskeletal Ewing sarcoma mimicking benign nerve sheath tumor. Ir J Med Sci (2012) 181:123-5. (24136179)
2013
2
Extraskeletal Ewing sarcoma in children and adolescents: impact of narrow but negative surgical margin. (23982393)
2013
3
A novel t(4;22)(q31;q12) produces an EWSR1-SMARCA5 fusion in extraskeletal Ewing sarcoma/primitive neuroectodermal tumor. (21113140)
2011
4
Primitive neuroectodermal tumor and extraskeletal Ewing sarcoma arising primarily around the spinal column: report of four cases and a review of the literature. (14520055)
2003

Variations for Extraskeletal Ewing Sarcoma

About this section

Expression for genes affiliated with Extraskeletal Ewing Sarcoma

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Extraskeletal Ewing Sarcoma

Search GEO for disease gene expression data for Extraskeletal Ewing Sarcoma.

Pathways for genes affiliated with Extraskeletal Ewing Sarcoma

About this section
Sources:
51PathCards, 31KEGG
See all sources

Pathways related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.5ERG, FLI1, EWSR1

Compounds for genes affiliated with Extraskeletal Ewing Sarcoma

About this section

GO Terms for genes affiliated with Extraskeletal Ewing Sarcoma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056348.0ERG, FLI1, SMARCA5, EWSR1

Biological processes related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription from RNA polymerase II promoterGO:0063669.1ERG, FLI1
2cell differentiationGO:0301548.8ERG, FLI1
3regulation of transcription from RNA polymerase II promoterGO:0063578.5ERG, FLI1, SMARCA5

Molecular functions related to Extraskeletal Ewing Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0009818.8ERG, FLI1
2DNA bindingGO:0036778.6ERG, FLI1, SMARCA5

Products for genes affiliated with Extraskeletal Ewing Sarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Extraskeletal Ewing Sarcoma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet