MCID: EXT003
MIFTS: 26

Extraskeletal Mesenchymal Chondrosarcoma malady

Categories: Cancer diseases

Aliases & Classifications for Extraskeletal Mesenchymal Chondrosarcoma

Aliases & Descriptions for Extraskeletal Mesenchymal Chondrosarcoma:

Name: Extraskeletal Mesenchymal Chondrosarcoma 12 14 69
Mesenchymal Extraosseous Chondrosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4548
NCIt 47 C27481
SNOMED-CT 64 404080006
UMLS 69 C1275279

Summaries for Extraskeletal Mesenchymal Chondrosarcoma

MalaCards based summary : Extraskeletal Mesenchymal Chondrosarcoma, also known as mesenchymal extraosseous chondrosarcoma, is related to chondrosarcoma and mesenchymal chondrosarcoma. An important gene associated with Extraskeletal Mesenchymal Chondrosarcoma is SSX1 (SSX Family Member 1), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include heart, pancreas and kidney, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Extraskeletal Mesenchymal Chondrosarcoma

Diseases related to Extraskeletal Mesenchymal Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 chondrosarcoma 10.7
2 mesenchymal chondrosarcoma 10.7
3 papillary ependymoma 10.0 SSX1 SSX2B
4 sick building syndrome 10.0 SSX1 SSX2B
5 lice infestation 10.0 SSX1 SSX2B
6 hypohidrosis 10.0 SSX1 SSX2B
7 cervicitis 9.9
8 amyloidosis, hereditary, transthyretin-related 9.9 SSX1 SSX2B
9 spindle cell rhabdomyosarcoma 9.8 AGO2 ENO2
10 gestational choriocarcinoma 9.7 ENO2 SSX1 SSX2B
11 type c thymoma 9.3 AGO2 CYP1A2 ENO2 SSX1 SSX2B

Graphical network of the top 20 diseases related to Extraskeletal Mesenchymal Chondrosarcoma:



Diseases related to Extraskeletal Mesenchymal Chondrosarcoma

Symptoms & Phenotypes for Extraskeletal Mesenchymal Chondrosarcoma

GenomeRNAi Phenotypes related to Extraskeletal Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.66 SSX2B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.66 AGO2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.66 AGO2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.66 SSX1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.66 AGO2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.66 AGO2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.66 SSX1 SSX2B AGO2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.66 AGO2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.66 AGO2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.66 SSX2B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.66 SSX1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.66 SSX2B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.66 AGO2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.66 SSX2B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.66 SSX1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.66 SSX1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.66 AGO2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.66 SSX2B
19 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.66 SSX2B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.66 AGO2
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.56 CYP1A2
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.56 CYP1A2 SSX2B
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.56 CYP1A2
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.56 SSX2B
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.56 CYP1A2
26 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.56 CYP1A2
27 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.56 SSX2B

Drugs & Therapeutics for Extraskeletal Mesenchymal Chondrosarcoma

Drugs for Extraskeletal Mesenchymal Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6 Alkylating Agents Phase 2, Phase 3
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9 Antineoplastic Agents, Alkylating Phase 2, Phase 3
10 Isophosphamide mustard Phase 2, Phase 3
11 Topoisomerase Inhibitors Phase 2, Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3

Search NIH Clinical Center for Extraskeletal Mesenchymal Chondrosarcoma

Genetic Tests for Extraskeletal Mesenchymal Chondrosarcoma

Anatomical Context for Extraskeletal Mesenchymal Chondrosarcoma

MalaCards organs/tissues related to Extraskeletal Mesenchymal Chondrosarcoma:

39
Heart, Pancreas, Kidney

Publications for Extraskeletal Mesenchymal Chondrosarcoma

Articles related to Extraskeletal Mesenchymal Chondrosarcoma:

(show all 44)
id Title Authors Year
1
Intracranial Extraskeletal Mesenchymal Chondrosarcoma. ( 27565470 )
2016
2
Coexistence of Extraskeletal Mesenchymal Chondrosarcoma and Isolated Hemihyperplasia: A Case Report. ( 27703933 )
2016
3
Imaging features of extraskeletal mesenchymal chondrosarcoma of the hand. ( 25797212 )
2015
4
A rare case of extraskeletal mesenchymal chondrosarcoma with dedifferentiation arising from the buccal space in a young male. ( 25838713 )
2015
5
Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma involving the vena cava: A case report. ( 24932271 )
2014
6
Management of renal extraskeletal mesenchymal chondrosarcoma. ( 25511186 )
2014
7
Primary extraskeletal mesenchymal chondrosarcoma of the vulva. ( 24328027 )
2013
8
Primary extraskeletal mesenchymal chondrosarcoma of the anterior mediastinum. ( 24255641 )
2013
9
Extraskeletal mesenchymal chondrosarcoma in the axillary region: reports of two cases. ( 23136576 )
2012
10
Radiological features and pathology of extraskeletal mesenchymal chondrosarcoma. ( 22726976 )
2012
11
Intramuscular, extraskeletal mesenchymal chondrosarcoma. ( 23548257 )
2011
12
Extraskeletal mesenchymal chondrosarcoma of the pleura: report of a rare case. ( 21393900 )
2011
13
Cytologic features and differential diagnosis in a case of extraskeletal mesenchymal chondrosarcoma: a case report. ( 20014564 )
2009
14
Extraskeletal mesenchymal chondrosarcoma of the forearm: a case report. ( 17336849 )
2007
15
Extraskeletal mesenchymal chondrosarcoma of the heart responded to systemic chemotherapy: a case report. ( 19746223 )
2007
16
Extraskeletal mesenchymal chondrosarcoma of the cervical meninx. ( 17705006 )
2007
17
Primary extraskeletal mesenchymal chondrosarcoma arising from the pancreas. ( 18071285 )
2007
18
Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma: a computed tomography diagnosis. ( 17989325 )
2007
19
Intracranial extraskeletal mesenchymal chondrosarcoma. ( 22266623 )
2006
20
Extraskeletal mesenchymal chondrosarcoma of the kidney. ( 16643625 )
2006
21
Extraskeletal mesenchymal chondrosarcoma: an imaging review of ten new patients. ( 16211384 )
2005
22
Cutaneous extraskeletal mesenchymal chondrosarcoma in a cat. ( 15842543 )
2005
23
Trisomy 8 as the sole cytogenetic abnormality in a case of extraskeletal mesenchymal chondrosarcoma. ( 15899388 )
2005
24
Imprint cytology of extraskeletal mesenchymal chondrosarcoma of the perineum: a case report. ( 15471258 )
2004
25
Extraskeletal mesenchymal chondrosarcoma: case report. ( 12727057 )
2003
26
Extraskeletal mesenchymal chondrosarcoma. ( 12908575 )
2003
27
Retroperitoneal extraskeletal mesenchymal chondrosarcoma in a dog. ( 12423033 )
2002
28
Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma. ( 12011263 )
2002
29
Intracranial extraskeletal mesenchymal chondrosarcoma: case report. ( 10626952 )
2000
30
Extraskeletal mesenchymal chondrosarcoma involving the heart: report of a case. ( 10929746 )
2000
31
Extraskeletal mesenchymal chondrosarcoma of the rectus sheath. ( 9297757 )
1997
32
Cytogenetic study of extraskeletal mesenchymal chondrosarcoma. A case report. ( 8603349 )
1996
33
Extraskeletal mesenchymal chondrosarcoma of the labium majus. ( 8774664 )
1996
34
Primary extraskeletal mesenchymal chondrosarcoma in fossa poplitea of a 93-year-old woman. ( 8950579 )
1996
35
Extraskeletal mesenchymal chondrosarcoma. ( 8430193 )
1993
36
Extraskeletal mesenchymal chondrosarcoma of the orbit. ( 8374880 )
1993
37
Extraskeletal mesenchymal chondrosarcoma of the mediastinum. ( 2242853 )
1990
38
Extraskeletal mesenchymal chondrosarcoma in a cow. ( 2794151 )
1989
39
Extraskeletal mesenchymal chondrosarcoma: case report and review of the literature. ( 2409241 )
1985
40
An ultrastructural study of extraskeletal mesenchymal chondrosarcoma. ( 6524380 )
1984
41
Extraskeletal mesenchymal chondrosarcoma of the orbit. ( 7174941 )
1982
42
Extraskeletal mesenchymal chondrosarcoma. A case report of extraskeletal case with review of the literature. ( 753003 )
1978
43
Case report. Extraskeletal mesenchymal chondrosarcoma. ( 750463 )
1978
44
Extraskeletal mesenchymal chondrosarcoma. ( 4694076 )
1973

Variations for Extraskeletal Mesenchymal Chondrosarcoma

Expression for Extraskeletal Mesenchymal Chondrosarcoma

Search GEO for disease gene expression data for Extraskeletal Mesenchymal Chondrosarcoma.

Pathways for Extraskeletal Mesenchymal Chondrosarcoma

Pathways related to Extraskeletal Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.88 SSX1 SSX2B

GO Terms for Extraskeletal Mesenchymal Chondrosarcoma

Biological processes related to Extraskeletal Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 post-embryonic development GO:0009791 8.96 AGO2 CYP1A2
2 negative regulation of nucleic acid-templated transcription GO:1903507 8.62 SSX1 SSX2B

Molecular functions related to Extraskeletal Mesenchymal Chondrosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription corepressor activity GO:0003714 8.96 SSX1 SSX2B
2 nucleic acid binding GO:0003676 8.8 AGO2 SSX1 SSX2B

Sources for Extraskeletal Mesenchymal Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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